Home Life Sciences Concomitant gastric carcinoma and primary hepatic angiosarcoma in a patient: A case report
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Concomitant gastric carcinoma and primary hepatic angiosarcoma in a patient: A case report

  • Qi Wang , Xuehai Xie , Yinmo Yang and Xiaodong Tian EMAIL logo
Published/Copyright: November 29, 2025
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Open Life Sciences
From the journal Open Life Sciences Volume 20 Issue 1

Abstract

Primary hepatic angiosarcoma (PHA) is a rare malignancy, and the occurrence of a dual malignancy involving both gastric cancer (GC) and PHA is even more exceptional. Here, we present a case of a 63-year-old man who complained of hiccups. PET-CT and Abdomen & Pelvis Routine Enhanced Scan results revealed a single liver mass and thickening of the inner wall of the gastric antrum. The pathologic biopsy confirmed the presence of GC in the antrum along the greater curvature. The initial diagnosis indicated GC with solitary liver metastasis, given the rarity of PHA. The patient underwent a radical distal gastrectomy and right posterior hepatic lobectomy. Postoperative pathology revealed early GC and PHA without any signs of lymphatic or distant metastases.

Keywords: gastric cancer; primary hepatic angiosarcoma; multiple primary cancer

1 Introduction

Gastric cancer (GC) is a prevalent malignant tumor that originates from epithelial cells in the stomach, ranking third in both incidence and mortality rates in China [1]. For early gastric cancer (EGC) patients who undergo endoscopic submucosal dissection (ESD), the 5-year rates of overall survival (OS), disease-specific survival, and relative survival were 92.6, 99.9, and 105.0%, respectively [2]. However, EGC with lymph node metastases has a relatively poor prognosis even after standard surgery [3]. Comprehensive therapies, including adjuvant and palliative chemotherapy, could be considered for these patients as well as those with advanced stages. Despite advancements in understanding the biological aspects of GC, surgical dissection or ESD remains a crucial cornerstone in the treatment with curative intent [4,5].

Primary hepatic angiosarcoma (PHA) is a rare and highly aggressive neoplasm that originates from the endothelial cells of blood vessels or lymphatic vessels. Approximately 200 cases are diagnosed annually worldwide [6]. Epidemiological prospective research indicates an incidence rate of PHA at approximately 0.5–2.5 cases per 10 million individuals [7]. Despite its rarity, it is the most common primary malignant mesenchymal tumor of the liver [6]. PHA is associated with prolonged latency following exposure to known chemical carcinogens such as vinyl chloride; however, 75% of the patients with no identifiable etiology [6,8]. Typically, PHA manifests in older men, with the highest incidence occurring in the sixth decade of life, and males are more commonly affected than females, with a ratio of 3–4:1 [6]. PHA is a rapid fatal neoplasm, with most patients succumbing within 6 months due to hepatic insufficiency or hemorrhagic complications [9,10]. Only 3% of the patients live more than 2 years with treatment [11], and the life expectancy after a liver transplant is less than 7 months [12]. Therefore, early diagnosis and radical resection of the tumor are crucial for effective treatment.

Multiple primary cancer (MPC) refers to the presence of more than one distinct malignant tumor diagnosed in a single patient, either concurrently or consecutively [13]. According to the criteria proposed by the World Health Organization in 2005 [14]: 1. the malignancy of each tumor must be confirmed through pathological examination; 2. each tumor must exhibit unique pathological morphology; 3. the tumors must occur at different sites; and 4. tumor metastasis must be excluded. Here, we present a case in which the patient was diagnosed with concurrent GC and HPA. Our aim is to provide evidence supporting surgical intervention as the optimal approach for early PHA. Additionally, we emphasize the importance of prioritizing liver puncture to identify the nature of digestive system tumors with a single hepatic mass. Such patients should also be given priority for surgical treatment rather than preoperative neoadjuvant therapy.

2 Case report

A 63-year-old male patient, who had a habit of consuming pickled foods, was admitted to the hospital due to persistent hiccups lasting for over 6 months. A gastroscopic examination conducted at a local hospital revealed an off-white lesion measuring 2.0 cm × 2.0 cm in the antrum of the stomach (Figure 1a). Pathologic examination revealed the presence of high-grade dysplasia and intramucosal adenocarcinoma. Subsequently, the patient was referred to Peking University First Hospital for surgery.

Figure 1 (a) The endoscopic biopsies confirmed the presence of gastric antrum cancer accompanied by mild chronic atrophic gastritis (C-2type) in the lesion located around the great curvature side of the antrum; (b) the Abdomen & Pelvis Routine Enhanced Scan CT detected the presence of a gastric lesion in the patient; (c) the postoperative specimen of GC; (d) the histopathological findings, encompassing hematoxylin and eosin (HE) staining and CK immunohistochemistry, unequivocally confirmed the presence of GC in the gastric lesion.
Figure 1

(a) The endoscopic biopsies confirmed the presence of gastric antrum cancer accompanied by mild chronic atrophic gastritis (C-2type) in the lesion located around the great curvature side of the antrum; (b) the Abdomen & Pelvis Routine Enhanced Scan CT detected the presence of a gastric lesion in the patient; (c) the postoperative specimen of GC; (d) the histopathological findings, encompassing hematoxylin and eosin (HE) staining and CK immunohistochemistry, unequivocally confirmed the presence of GC in the gastric lesion.

The physical assessment showed no notable abnormalities, and tumor markers, including alpha-fetoprotein (AFP), carcinoembryonic antigen, carbohydrate antigen 19-9, total prostate-specific antigen (tPSA), free prostate-specific antigen (fPSA), fPSA/tPSA (f/t), squamous cell carcinoma associated antigen, cytokeratin 19 fragments (CYFRA21-1), neuron-specific enolase, carbohydrate antigen 72-4, pro-gastrin-releasing peptide, and carbohydrate antigen 24-2, were within normal range. The Abdomen & Pelvis Routine Enhanced CT scan revealed thickening of the inner wall of the gastric antrum (Figure 1b). Additionally, the enhanced CT scan showed a solitary mass in the liver with ring-like enhancement at the periphery in the arterial phase, indistinct boundaries during the venous phase, and ring-like enhancement at the edges in the subsequent delayed phase (Figure 2a). The solitary hepatic mass was initially identified as a metastatic lesion originating from GC, consistent with the liver being the primary site of metastasis for tumors originating from the digestive system. PET-CT, used for detecting metastases, showed elevated glucose metabolism in the hepatic lesion (Figure 2b).

Figure 2 (a) The Abdomen & Pelvis Routine Enhanced Scan CT revealed a solitary hepatic lesion; (b) the PET-CT scan confirmed elevated glucose metabolism in the hepatic lesion; (c) the liver specimen; (d) the histopathological findings encompassing HE staining, CD31 immunohistochemistry, ERG immunostaining, and CK immunohistochemistry, unequivocally confirmed the presence of hepatic angiosarcoma in the liver specimen.
Figure 2

(a) The Abdomen & Pelvis Routine Enhanced Scan CT revealed a solitary hepatic lesion; (b) the PET-CT scan confirmed elevated glucose metabolism in the hepatic lesion; (c) the liver specimen; (d) the histopathological findings encompassing HE staining, CD31 immunohistochemistry, ERG immunostaining, and CK immunohistochemistry, unequivocally confirmed the presence of hepatic angiosarcoma in the liver specimen.

A successful radical distal gastrectomy and resection of the right posterior lobe of the liver were performed, as surgery is the optimal therapeutic approach for this patient [15]. Following the operation, the hiccup symptom was significantly relieved. The gastric lesion, measuring 22 mm × 20 mm × 5 mm and accompanied by a superficial ulcer (Figure 1c), was diagnosed as early-stage gastric cancer (T1bN0M0) (Figure 1d). Immunohistochemical analysis of the 33 mm × 25 mm × 25 mm mass in the right liver (Figure 2c) demonstrated positive expression of CD31 [6], ERG [16], and negative expression of CK markers (Figure 2d), leading to a diagnosis of PHA. Fortunately, the patient’s GC and PHA showed no evidence of lymph node metastases or distant metastases. The patient recovered well and was discharged from the hospital. He was advised to undergo a review of tumor markers, and abdominal CT scans every 3 months. At 36-month follow-up, he remained well and disease-free with no subsequent need for chemotherapy.

  1. Informed consent: Informed consent has been obtained from all individuals included in this study.

  2. Ethical approval: The research related to human use has complied with all the relevant national regulations and institutional policies, is in accordance with the tenets of the Helsinki Declaration, and has been approved by the Peking University First Hospital (2024 study 194-002).

3 Discussion

This special case presents two distinctive characteristics. First, PHA, an aggressive and rare tumor, poses a challenge due to the lack of established and effective treatment guidelines owing to its low frequency [6]. Second, the concurrent EGC adds to the rarity of this case.

In this case, the patient initially presented with gastrointestinal symptoms and a solitary mass in the liver was detected during a CT scan. Given the rarity of PHA, the negative of AFP, and the liver being identified as the primary site of metastasis for GC [17], our initial diagnosis for the patient was primary GC with solitary hepatic metastasis. In light of this, the patient was presented with two options: neoadjuvant chemotherapy followed by surgical intervention or direct progression to surgery. In recent decades, there has been an evaluation of comprehensive therapy methods involving a combination of surgery, chemotherapy, and gastrectomy with trans-arterial chemoembolization plus systemic chemotherapy (GTC) in patients with GC and liver metastasis [18]. Some patients are ineligible for surgical procedures due to the association of liver metastasis with extrahepatic diseases, such as peritoneal dissemination, lymph node metastasis, and direct invasion of other organs by cancer [19]. However, Saiura et al. [20] argued that patients with liver metastasis from GC who undergo hepatic resection have a higher likelihood of long-term survival in the absence of lymph node metastasis at the primary site. Markar et al. [15] found that among patients diagnosed with GC, those who underwent curative surgery combined with hepatectomy had a better survival time compared to those who only underwent gastrectomy, and their survival time was similar to that of patients undergoing gastrectomy without liver metastasis. Other studies have also suggested that surgical resection of liver metastases from GC may benefit patients with solitary metastasis [21,22,23]. The successful surgical procedure involved distal gastrectomy and resection of the right posterior lobe of the liver. This decision was prompted by the presence of a solitary liver mass and the absence of metastases on PET-CT. Subsequent pathological analysis confirmed that the liver lesion is PHA based on the immunohistochemistry evidence and immune markers.

PHA typically presents as a multicentric occurrence involving both lobes of the liver, with multifocal masses occasionally affecting the entire hepatic tissue [6]. Abdominal pain was the most common symptom for 66% of the patients, while 12.5% of the patients presented with atypical symptoms [16]. Patients may also present with ascites, heart palpitations, cough, hepatomegaly, acute abdominal crisis, backache, weakness, weight loss, fever, anemia, hemoperitoneum, and other symptoms indicative of distant metastases (such as lung, peritoneum, bone, and spleen) [6,9,11,16]. In this study, the primary symptom in this patient was persistent hiccups, not hepatic discomfort, despite the presence of a large mass in the liver. Due to the absence of specific imaging features, pathological biopsy remains the primary diagnostic method. However, fine needle aspiration cytology is limited by the potential risk of fatal hemorrhage [24]. CD31 [6] and ERG [16] have been proven to be sensitive and specific diagnostic markers. Vimentin, GPC-3, desmin, Ki-67, CD34, and factor VIII-related antigens have been reported as positive in PHA [6,16]. The pathological findings in this case were consistent with the aforementioned markers. It is worth noting that while the cytokeratin expression of PHA in this case is negative, some angiosarcomas have been shown to be positive for cytokeratin [25,26]. In the absence of CD31 and ERG expression, a positive cytokeratin result may lead to the misdiagnosis of the tumor as epithelial in origin.

Radical surgical resection appears to be the most effective treatment method for PHA [10]. Due to the lack of noticeable symptoms and the aggressive nature of PHA, only 20% of the cases are considered suitable for hepatic resection [6]. Liver transplantation appears to be an effective treatment option for patients with entire liver involvement by tumors. However, certain studies have cautioned against performing liver transplantation in patients with PHA due to the high recurrence rate and rapid disease progression, which leads to a median survival of less than 7 months post-transplantation [12,27]. Kim et al. [28] demonstrated that chemotherapy improved survival rates in 2 out of 4 patients with advanced PHA and distant metastasis. The study recommended the utilization of 5-FU-carboplatin in combination with doxorubicin or ifosfamide for treatment. Palliative chemotherapy may be the only treatment option available for those patients. A study showed that the median OS and disease-free survival of patients with PHA after surgical resection were 18 months (range: 3–144 months) and 10 months (range: 2–144 months), respectively [29]. In a study involving six patients diagnosed with PHA and presenting with a solitary mass, three patients underwent right hepatectomy, one patient underwent extended right hepatectomy, and two patients underwent left hepatectomy. Among these patients, two survived for more than 12 months post-surgery, and one patient achieved a survival period of over 29 months without recurrence [30]. In this case, although the PHA volume measured 33 mm × 25 mm × 25 mm, postoperative pathology revealed no signs of lymph node metastasis, and PET-CT indicated no distant metastasis. The patient did not receive chemotherapy following surgery but was advised to undergo a review every 3 months. Presently, it has been 36 months since the surgery, and no recurrence has been observed. This case helps bolster our support for surgery as the optimal treatment for PHA, capable of extending patients’ survival.

In this case, whether it was GC or PHA, the patient did not exhibit typical symptoms. GC is currently believed to be primarily caused by H. pylori infection, autoimmune atrophic gastritis, and poor dietary habits, while PHA is primarily associated with exposure to known chemical carcinogens over a prolonged period, although 75% of the patients have no known etiology [6]. The etiologies of the two conditions do not significantly overlap. Furthermore, there have been no previous reports, to the best of our knowledge, of both occurring simultaneously or sequentially in a single patient. Genetic testing was conducted for the patient’s two tumors. In the case of GC, we detected 0 primary mutations, 1 secondary mutation (VEGFA), and 7 tertiary mutations (ASXL1, CARD11, CDKN2A, E2F3, GRIN2A, PIK3CA, and TP53). Interestingly, the above-mentioned mutated genes were not detected in the PHA. This indicates that the patient’s GC and PHA are not directly related. Additionally, both PHA and GC are MSS/MSI-L.

In summary, it is important to carefully consider the potential presence of PHA in AFP-free cases where an endoscopic biopsy indicates EGC and a CT scan reveals a hepatic mass. While standardized treatment guidelines for PHA are still being developed, surgical intervention remains the optimal choice for patients with a solitary hepatic mass. In the absence of a lymph node or distant metastatic PHA, chemotherapy may not be necessary. Additionally, we recommend prioritizing surgical treatment for patients with GC accompanied by a solitary liver mass, regardless of whether the liver mass is a metastasis.

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Acknowledgments

The authors are grateful for the reviewer’s valuable comments that improve the manuscript.

  1. Funding information: This study was supported in part by grants 81572339 (to X. Tian), 81672353, and 81871954 (to Y. Yang) from the National Natural Science Foundation of China.

  2. Author contributions: Qi Wang wrote the main manuscript text, Xuehai Xie was involved in the data analysis, Yinmo Yang reviewed the manuscript, and Xiaodong Tian provided fund support and oversaw the project.

  3. Conflict of interest: Authors state no conflict of interest.

  4. Data availability statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Received: 2024-03-24
Revised: 2024-07-27
Accepted: 2024-08-09
Published Online: 2025-11-29

© 2025 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  114. Biogenic Cu/Ni nanotherapeutics from Descurainia sophia (L.) Webb ex Prantl seeds for the treatment of lung cancer
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  116. Glycitein alleviates inflammation and apoptosis in keratinocytes via ROS-associated PI3K–Akt signalling pathway
  117. ADH5 inhibits proliferation but promotes EMT in non-small cell lung cancer cell through activating Smad2/Smad3
  118. Apoptotic efficacies of AgNPs formulated by Syzygium aromaticum leaf extract on 32D-FLT3-ITD human leukemia cell line with PI3K/AKT/mTOR signaling pathway
  119. Novel cuproptosis-related genes C1QBP and PFKP identified as prognostic and therapeutic targets in lung adenocarcinoma
  120. Bee venom promotes exosome secretion and alters miRNA cargo in T cells
  121. Treatment of pure red cell aplasia in a chronic kidney disease patient with roxadustat: A case report
  122. Comparative bioinformatics analysis of the Wnt pathway in breast cancer: Selection of novel biomarker panels associated with ER status
  123. Kynurenine facilitates renal cell carcinoma progression by suppressing M2 macrophage pyroptosis through inhibition of CASP1 cleavage
  124. RFX5 promotes the growth, motility, and inhibits apoptosis of gastric adenocarcinoma cells through the SIRT1/AMPK axis
  125. ALKBH5 exacerbates early cardiac damage after radiotherapy for breast cancer via m6A demethylation of TLR4
  126. Phytochemicals of Roman chamomile: Antioxidant, anti-aging, and whitening activities of distillation residues
  127. Circadian gene Cry1 inhibits the tumorigenicity of hepatocellular carcinoma by the BAX/BCL2-mediated apoptosis pathway
  128. The TNFR-RIPK1/RIPK3 signalling pathway mediates the effect of lanthanum on necroptosis of nerve cells
  129. Longitudinal monitoring of autoantibody dynamics in patients with early-stage non-small-cell lung cancer undergoing surgery
  130. The potential role of rutin, a flavonoid, in the management of cancer through modulation of cell signaling pathways
  131. Construction of pectinase gene engineering microbe and its application in tobacco sheets
  132. Construction of a microbial abundance prognostic scoring model based on intratumoral microbial data for predicting the prognosis of lung squamous cell carcinoma
  133. Sepsis complicated by haemophagocytic lymphohistiocytosis triggered by methicillin-resistant Staphylococcus aureus and human herpesvirus 8 in an immunocompromised elderly patient: A case report
  134. Sarcopenia in liver transplantation: A comprehensive bibliometric study of current research trends and future directions
  135. Advances in cancer immunotherapy and future directions in personalized medicine
  136. Can coronavirus disease 2019 affect male fertility or cause spontaneous abortion? A two-sample Mendelian randomization analysis
  137. Heat stroke associated with novel leukaemia inhibitory factor receptor gene variant in a Chinese infant
  138. PSME2 exacerbates ulcerative colitis by disrupting intestinal barrier function and promoting autophagy-dependent inflammation
  139. Hyperosmolar hyperglycemic state with severe hypernatremia coexisting with central diabetes insipidus: A case report and literature review
  140. Efficacy and mechanism of escin in improving the tissue microenvironment of blood vessel walls via anti-inflammatory and anticoagulant effects: Implications for clinical practice
  141. Merkel cell carcinoma: Clinicopathological analysis of three patients and literature review
  142. Genetic variants in VWF exon 26 and their implications for type 1 Von Willebrand disease in a Saudi Arabian population
  143. Lipoxin A4 improves myocardial ischemia/reperfusion injury through the Notch1-Nrf2 signaling pathway
  144. High levels of EPHB2 expression predict a poor prognosis and promote tumor progression in endometrial cancer
  145. Knockdown of SHP-2 delays renal tubular epithelial cell injury in diabetic nephropathy by inhibiting NLRP3 inflammasome-mediated pyroptosis
  146. Exploring the toxicity mechanisms and detoxification methods of Rhizoma Paridis
  147. Concomitant gastric carcinoma and primary hepatic angiosarcoma in a patient: A case report
  148. Ecology and Environmental Science
  149. Optimization and comparative study of Bacillus consortia for cellulolytic potential and cellulase enzyme activity
  150. The complete mitochondrial genome analysis of Haemaphysalis hystricis Supino, 1897 (Ixodida: Ixodidae) and its phylogenetic implications
  151. Epidemiological characteristics and risk factors analysis of multidrug-resistant tuberculosis among tuberculosis population in Huzhou City, Eastern China
  152. Indices of human impacts on landscapes: How do they reflect the proportions of natural habitats?
  153. Genetic analysis of the Siberian flying squirrel population in the northern Changbai Mountains, Northeast China: Insights into population status and conservation
  154. Diversity and environmental drivers of Suillus communities in Pinus sylvestris var. mongolica forests of Inner Mongolia
  155. Global assessment of the fate of nitrogen deposition in forest ecosystems: Insights from 15N tracer studies
  156. Fungal and bacterial pathogenic co-infections mainly lead to the assembly of microbial community in tobacco stems
  157. Influencing of coal industry related airborne particulate matter on ocular surface tear film injury and inflammatory factor expression in Sprague-Dawley rats
  158. Temperature-dependent development, predation, and life table of Sphaerophoria macrogaster (Thomson) (Diptera: Syrphidae) feeding on Myzus persicae (Sulzer) (Homoptera: Aphididae)
  159. Eleonora’s falcon trophic interactions with insects within its breeding range: A systematic review
  160. Agriculture
  161. Integrated analysis of transcriptome, sRNAome, and degradome involved in the drought-response of maize Zhengdan958
  162. Variation in flower frost tolerance among seven apple cultivars and transcriptome response patterns in two contrastingly frost-tolerant selected cultivars
  163. Heritability of durable resistance to stripe rust in bread wheat (Triticum aestivum L.)
  164. Molecular mechanism of follicular development in laying hens based on the regulation of water metabolism
  165. Animal Science
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  167. Plant Sciences
  168. Hairpin in a haystack: In silico identification and characterization of plant-conserved microRNA in Rafflesiaceae
  169. Widely targeted metabolomics of different tissues in Rubus corchorifolius
  170. The complete chloroplast genome of Gerbera piloselloides (L.) Cass., 1820 (Carduoideae, Asteraceae) and its phylogenetic analysis
  171. Field trial to correlate mineral solubilization activity of Pseudomonas aeruginosa and biochemical content of groundnut plants
  172. Correlation analysis between semen routine parameters and sperm DNA fragmentation index in patients with semen non-liquefaction: A retrospective study
  173. Plasticity of the anatomical traits of Rhododendron L. (Ericaceae) leaves and its implications in adaptation to the plateau environment
  174. Effects of Piriformospora indica and arbuscular mycorrhizal fungus on growth and physiology of Moringa oleifera under low-temperature stress
  175. Effects of different sources of potassium fertiliser on yield, fruit quality and nutrient absorption in “Harward” kiwifruit (Actinidia deliciosa)
  176. Comparative efficiency and residue levels of spraying programs against powdery mildew in grape varieties
  177. The DREB7 transcription factor enhances salt tolerance in soybean plants under salt stress
  178. Using plant electrical signals of water hyacinth (Eichhornia crassipes) for water pollution monitoring
  179. Food Science
  180. Phytochemical analysis of Stachys iva: Discovering the optimal extract conditions and its bioactive compounds
  181. Review on role of honey in disease prevention and treatment through modulation of biological activities
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  183. Optimization of phenolic compound extraction from Tunisian squash by-products: A sustainable approach for antioxidant and antibacterial applications
  184. Liupao tea aqueous extract alleviates dextran sulfate sodium-induced ulcerative colitis in rats by modulating the gut microbiota
  185. Toxicological qualities and detoxification trends of fruit by-products for valorization: A review
  186. Polyphenolic spectrum of cornelian cherry fruits and their health-promoting effect
  187. Optimizing the encapsulation of the refined extract of squash peels for functional food applications: A sustainable approach to reduce food waste
  188. Advancements in curcuminoid formulations: An update on bioavailability enhancement strategies curcuminoid bioavailability and formulations
  189. Impact of saline sprouting on antioxidant properties and bioactive compounds in chia seeds
  190. The dilemma of food genetics and improvement
  191. Bioengineering and Biotechnology
  192. Impact of hyaluronic acid-modified hafnium metalorganic frameworks containing rhynchophylline on Alzheimer’s disease
  193. Emerging patterns in nanoparticle-based therapeutic approaches for rheumatoid arthritis: A comprehensive bibliometric and visual analysis spanning two decades
  194. Application of CRISPR/Cas gene editing for infectious disease control in poultry
  195. Preparation of hafnium nitride-coated titanium implants by magnetron sputtering technology and evaluation of their antibacterial properties and biocompatibility
  196. Preparation and characterization of lemongrass oil nanoemulsion: Antimicrobial, antibiofilm, antioxidant, and anticancer activities
  197. Corrigendum
  198. Corrigendum to “Utilization of convolutional neural networks to analyze microscopic images for high-throughput screening of mesenchymal stem cells”
  199. Corrigendum to “Effects of Ire1 gene on virulence and pathogenicity of Candida albicans”
  200. Retraction
  201. Retraction of “Down-regulation of miR-539 indicates poor prognosis in patients with pancreatic cancer”
https://doi.org/10.1515/biol-2022-0961
Keywords for this article
gastric cancer; primary hepatic angiosarcoma; multiple primary cancer
Creative Commons
BY 4.0

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  119. Novel cuproptosis-related genes C1QBP and PFKP identified as prognostic and therapeutic targets in lung adenocarcinoma
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  127. Circadian gene Cry1 inhibits the tumorigenicity of hepatocellular carcinoma by the BAX/BCL2-mediated apoptosis pathway
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  136. Can coronavirus disease 2019 affect male fertility or cause spontaneous abortion? A two-sample Mendelian randomization analysis
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  138. PSME2 exacerbates ulcerative colitis by disrupting intestinal barrier function and promoting autophagy-dependent inflammation
  139. Hyperosmolar hyperglycemic state with severe hypernatremia coexisting with central diabetes insipidus: A case report and literature review
  140. Efficacy and mechanism of escin in improving the tissue microenvironment of blood vessel walls via anti-inflammatory and anticoagulant effects: Implications for clinical practice
  141. Merkel cell carcinoma: Clinicopathological analysis of three patients and literature review
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  143. Lipoxin A4 improves myocardial ischemia/reperfusion injury through the Notch1-Nrf2 signaling pathway
  144. High levels of EPHB2 expression predict a poor prognosis and promote tumor progression in endometrial cancer
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  151. Epidemiological characteristics and risk factors analysis of multidrug-resistant tuberculosis among tuberculosis population in Huzhou City, Eastern China
  152. Indices of human impacts on landscapes: How do they reflect the proportions of natural habitats?
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  154. Diversity and environmental drivers of Suillus communities in Pinus sylvestris var. mongolica forests of Inner Mongolia
  155. Global assessment of the fate of nitrogen deposition in forest ecosystems: Insights from 15N tracer studies
  156. Fungal and bacterial pathogenic co-infections mainly lead to the assembly of microbial community in tobacco stems
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  158. Temperature-dependent development, predation, and life table of Sphaerophoria macrogaster (Thomson) (Diptera: Syrphidae) feeding on Myzus persicae (Sulzer) (Homoptera: Aphididae)
  159. Eleonora’s falcon trophic interactions with insects within its breeding range: A systematic review
  160. Agriculture
  161. Integrated analysis of transcriptome, sRNAome, and degradome involved in the drought-response of maize Zhengdan958
  162. Variation in flower frost tolerance among seven apple cultivars and transcriptome response patterns in two contrastingly frost-tolerant selected cultivars
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  164. Molecular mechanism of follicular development in laying hens based on the regulation of water metabolism
  165. Animal Science
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  167. Plant Sciences
  168. Hairpin in a haystack: In silico identification and characterization of plant-conserved microRNA in Rafflesiaceae
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  170. The complete chloroplast genome of Gerbera piloselloides (L.) Cass., 1820 (Carduoideae, Asteraceae) and its phylogenetic analysis
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  172. Correlation analysis between semen routine parameters and sperm DNA fragmentation index in patients with semen non-liquefaction: A retrospective study
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  174. Effects of Piriformospora indica and arbuscular mycorrhizal fungus on growth and physiology of Moringa oleifera under low-temperature stress
  175. Effects of different sources of potassium fertiliser on yield, fruit quality and nutrient absorption in “Harward” kiwifruit (Actinidia deliciosa)
  176. Comparative efficiency and residue levels of spraying programs against powdery mildew in grape varieties
  177. The DREB7 transcription factor enhances salt tolerance in soybean plants under salt stress
  178. Using plant electrical signals of water hyacinth (Eichhornia crassipes) for water pollution monitoring
  179. Food Science
  180. Phytochemical analysis of Stachys iva: Discovering the optimal extract conditions and its bioactive compounds
  181. Review on role of honey in disease prevention and treatment through modulation of biological activities
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  183. Optimization of phenolic compound extraction from Tunisian squash by-products: A sustainable approach for antioxidant and antibacterial applications
  184. Liupao tea aqueous extract alleviates dextran sulfate sodium-induced ulcerative colitis in rats by modulating the gut microbiota
  185. Toxicological qualities and detoxification trends of fruit by-products for valorization: A review
  186. Polyphenolic spectrum of cornelian cherry fruits and their health-promoting effect
  187. Optimizing the encapsulation of the refined extract of squash peels for functional food applications: A sustainable approach to reduce food waste
  188. Advancements in curcuminoid formulations: An update on bioavailability enhancement strategies curcuminoid bioavailability and formulations
  189. Impact of saline sprouting on antioxidant properties and bioactive compounds in chia seeds
  190. The dilemma of food genetics and improvement
  191. Bioengineering and Biotechnology
  192. Impact of hyaluronic acid-modified hafnium metalorganic frameworks containing rhynchophylline on Alzheimer’s disease
  193. Emerging patterns in nanoparticle-based therapeutic approaches for rheumatoid arthritis: A comprehensive bibliometric and visual analysis spanning two decades
  194. Application of CRISPR/Cas gene editing for infectious disease control in poultry
  195. Preparation of hafnium nitride-coated titanium implants by magnetron sputtering technology and evaluation of their antibacterial properties and biocompatibility
  196. Preparation and characterization of lemongrass oil nanoemulsion: Antimicrobial, antibiofilm, antioxidant, and anticancer activities
  197. Corrigendum
  198. Corrigendum to “Utilization of convolutional neural networks to analyze microscopic images for high-throughput screening of mesenchymal stem cells”
  199. Corrigendum to “Effects of Ire1 gene on virulence and pathogenicity of Candida albicans”
  200. Retraction
  201. Retraction of “Down-regulation of miR-539 indicates poor prognosis in patients with pancreatic cancer”
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