Home Effects of physical exercise on biomarkers of oxidative stress in healthy subjects: A meta-analysis of randomized controlled trials
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Effects of physical exercise on biomarkers of oxidative stress in healthy subjects: A meta-analysis of randomized controlled trials

  • Yahai Wang , Donglin Luo , Haichao Jiang , Yu Song , Zhiqiang Wang , Lin Shao EMAIL logo and Yuxiao Liu EMAIL logo
Published/Copyright: August 8, 2023
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Open Life Sciences
From the journal Open Life Sciences Volume 18 Issue 1

Abstract

This meta-analysis investigated the effect of physical exercise (PE) on the levels of oxidative biomarkers in randomized controlled trials (RCTs) involving healthy subjects. We searched five databases for articles until May 1, 2023. A random-effect meta-analysis, subgroup analysis, meta-regressions as well as trim and fill method were conducted using STATA 11.0, involving ten articles. According to the results of the meta-analysis, PE had no significant effect on superoxide dismutase (SOD), glutathione peroxidase, and catalase levels. PE induced significant increase in total antioxidant status (standardized mean difference [SMD] 1.53, 95% CI 0.73–2.32), and PE could significantly reduce the level of malondialdehyde (MDA) (SMD −1.11, 95% CI −2.15 to −0.06). Sensitivity analyses and subgroup analyses showed that male participants, body mass index (BMI) <25, exercise duration between 1 and 12 weeks, resistance exercise or multicomponent exercise, and exercise of low or moderate intensity were associated with a significant PE-induced decrease in MDA concentrations. Meta-regression analysis identified the age of the participants as a confounder of the effect of PE on SOD levels. The older age of the subjects was associated in a gradient fashion with incident SOD levels. Further RCTs are required to investigate the optimal PE protocol for people of different ages and BMI as well as the effect of PE on oxidative stress.

Keywords: physical exercise; oxidative stress; meta-analysis.

1 Introduction

Globally, roughly 27.5% of adults [1] and 81% of adolescents [2] are physically inactive, which increases 6–10% risk of chronic diseases, premature death [3], and the risk of dementia [4]. Physical exercise (PE) is a non-pharmaceutical method for preventing diseases in which the antioxidant defense plays a key role [5,6]. Additionally, PE could reduce insulin resistance [7,8] which is related to the inhibition of inflammation [9,10] and oxidative stress [11]. Therefore, it is essential to explore the influence of PE on oxidative stress, which is a key pathogenic element in the onset and progression of numerous chronic diseases [12,13].

Oxidative stress is associated with the progression of many non-communicable diseases [13,14] and is characterized by an increase in reactive oxygen species (ROS) and reactive nitrogen species. PE can temporarily induce the production of ROS [15], which results in a compensatory increase in antioxidant levels. This contributes to exercise-induced adaptation of skeletal muscle in vivo [16], eventually producing positive or harmful effects according to the activated oxidoreductive status [17,18]. The effects of PE on oxidative stress have been a source of contentious debate, mainly because the changes in oxidative metabolism vary greatly with the exercise protocols and populations, making it difficult to reach a consensus.

The primary objective of this meta-analysis is to investigate the association between exercise intervention and oxidative stress in order to make recommendations for future exercise interventions.

2 Materials and methods

2.1 Literature search

This meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines [19]. On the basis of the Population, Intervention, Comparator, Outcome, and Study design framework, articles published between 1980 and May 1, 2023 were retrieved from PubMed, Web of Science, Cochrane Library, Scopus, and Embase. The following search strategy was used: (“Exercise” OR “Physical Exercise” OR “Exercise Therapy”) AND (“Oxidative Stress” OR “Antioxidants”) AND “randomized controlled trial.” Detailed search strategies are shown in Table S1.

2.2 Study selection

Two researchers (Y.H.W. and D.L.L.) independently screened titles and abstracts, followed by the full-text, to determine eligibility. The third researcher (H.C.J.) arbitrated any disagreements so that a consensus could be reached. In addition, we manually searched for references to include publications and pertinent review articles. The study includes research and review publications that met the following inclusion criteria: (1) randomized controlled trials (RCTs) that are parallel or crossover; (2) the volunteers were healthy individuals; (3) the intervention of interest was any intensity, frequency, or duration of PE; PE versus non-exercise control or PE plus other intervention versus other intervention only were compared; (4) the outcomes of focus were plasma or serum biomarkers for oxidative stress; and (5) articles published after 1980. The exclusion criteria included: (1) studies involving sick individuals and (2) studies lacking baseline data or data on the final assessment of outcomes in both intervention groups and comparators used to calculate mean changes of treatment ± standard deviation (SD).

2.3 Data extraction and quality assessment

Two trained researchers (Y.H.W. and D.L.L.) performed independent data extraction and quality evaluation. The retrieved data comprised the surname of the first author, publication year, study design, study location, sample size, participants’ age and gender, participants’ baseline body mass index (BMI), PE intervention (duration, kind, intensity, frequency), and the results of reported biomarkers. Two or more PE intervention strata (e.g., different forms, intensities, frequencies, or durations of PE) were analyzed as distinct trials. This review included all sorts of PE (aerobic exercise, resistance exercise, and multicomponent exercise). In accordance with American College of Sports Medicine recommendations, the intensity of PE was categorized by maximal heart rate (HRmax), maximal oxygen uptake (VO2peak), and maximum repetitions (RM) [20]. The methodological quality and risk of bias of each included study were evaluated using the PEDro scale [21]. The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) system was used to assess the evidence level of each outcome [22]. According to the GRADE standards, research design determines the baseline quality of the evidence (RCTs were previously considered as high quality), but other factors may diminish (e.g., unexplained heterogeneity) or increase (e.g., a significant magnitude of effect) the studies’ quality [22]. Disagreements were resolved via dialogue with the third reviewer (H.C.J.).

2.4 Statistical analysis

There were differences among the included studies in study participants, PE protocols employed, and the measurement of oxidative biomarkers. Thus, the random effects model was used to pool estimates of net changes (changes of intervention group minus changes of control group) in the concentrations of biomarkers, and the results were presented as standardized mean difference (SMD) with 95% confidence intervals (CIs). According to the technique proposed by Wan et al. [23], advanced data extraction was employed for studies that did not directly give either the baseline or final mean and SD of outcomes.

Initially, a primary meta-analysis was performed to determine the overall impact of PE on each oxidative biomarker. On the basis of the quality of the studies, sensitivity analyses were conducted to determine the robustness of the initial meta-analysis’ conclusions. Sources of potential heterogeneity were identified by carrying out subgroup analyses based on region, gender, age of participants, baseline BMI of participants, duration of intervention, type of PE, and intensity of PE (only conducted if more than six trials reported the same outcomes). Using meta-regression analysis, differences between groups and causes of heterogeneity were analyzed. Further meta-regression analyses were conducted to investigate potential moderators and examine the association between moderators and outcomes, with p-value <0.1 being considered as statistically significant. The heterogeneity among studies was tested using Cochrane’s Q test and quantified using I 2-statistic [24]. I 2 > 50% and p < 0.10 for the Q test show the presence of heterogeneity. Begg’s and Egger’s regression tests and funnel plots were used to evaluate publication bias, with a p < 0.10 indicating the presence of bias [25]. If publication bias was detected, the trim and fill approach was employed to eliminate very small studies and recalculate the pooled effect until the funnel plot was symmetrical [26]. All analyses were performed using STATA version 11.0 (Stata Corp, College Station, TX, USA), with double data input to avoid input errors. p < 0.05 was deemed as statistically significant unless specified elsewhere.

3 Results

3.1 Flow of study selection

The flowchart depicting the study selection procedure is shown in Figure 1. Initially, 11,479 publications were retrieved, but after excluding the duplicates and screening the titles and abstracts, only 750 articles were left for full-text review. A further 740 articles were eliminated for the following reasons: 227 articles did not involve RCT design, participants of 135 studies were not healthy, 199 articles had improper intervention or control, assessable target outcomes were not reported in 154 articles, and 25 articles lacked sufficient data for quantitative analysis. Finally, ten studies [27–36] involving 458 participants were included in the final meta-analysis.

Figure 1 Flowchart showing the procedure used for study selection.
Figure 1

Flowchart showing the procedure used for study selection.

3.2 Qualities of included studies and outcome measure evidence by GRADE system

The quality of the methodology of ten studies were rated as good quality (6–8 scores) mainly due to lack of blinding according to the PEDro scale (Table 1). According to the GRADE system, the quality of evidence for malondialdehyde (MDA) and total antioxidant status (TAS) was moderate, while the quality of evidence for superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) was low (Table 2).

Table 1

Characteristics of included studies in this meta-analysis (ten studies)

Study Design Country Subject Comparators Interventions Duration of intervention Method of measuring/biomarkers outcomes Qualitya
Alghadir, 2016 RP Saudi Arabia Healthy subjects ( N = 100) Control ( N = 50): Not described. Aerobic exercise ( N = 50): stretching exercises and walking (5–10 min); treadmill, bicycle, and stair training (45–60 min). 24 wk ELISA/TAS, MDA Good
Intensity: 30–45% of VO2max
Frequency: 3 times/wk
Azizbeigi, 2015 RP Iran Male physical education students ( N = 30) Control ( N = 10): Not described. Resistance exercise ( N = 20): upper body and lower body exercises: chest press, lat pull down, leg extension and flexion, biceps and triceps curls, squats, and sit-ups. 8 wk Not described/SOD, GPx, MDA Good
Intensity: 65–70% (moderate intensity group, N = 10)/85–90% (high intensity group, N = 10) of 1RM.
Frequency: 3 times/wk
Alikhani, 2019 RP Iran Young and older adult women ( N = 24) Control ( N = 24): No exercise. Resistance exercise ( N = 24): 10 min to warm-up, 45 min for the main training phase and 5 min for cool-down in each session. ELISA/MDA, TAS Good
Intensity: 75% of 1RM.
Frequency: 3 times/wk
Bunpo, 2016 RP Thailand Healthy untrained adult ( N = 26) Control ( N = 16): Sedentary Aerobic exercise ( N = 10): outdoor running (30 min). 12 wk Thiobarbituric acid reactive substances/TAS, SOD, MDA Good
Intensity: 65–75% of HRmax
Frequency: 3 times/wk
Dani, 2021 RP Brazil Healthy elderly women ( N = 10) Control ( N = 9): Sedentary Multicomponent exercise ( N = 31): 10 min warm-up and 40 min of strengthening, balance, functional capacity, motor coordination and cognition exercises, resistance exercises for the upper sessions, squatting associated with the resistance motor task, among other variations. 10 min stretching exercises. Spectrometer/SOD, CAT Good
Intensity:/
Frequency: 2 times/wk
Fatouros, 2004 RP Greece Healthy older men ( N = 19) Control ( N = 8): Non-exercising. Aerobic exercise ( N = 11): warm-up (3–5 min); treadmill walking/jogging (12–42 min). 16 wk Spectrometer/TAS, MDA, GPx Good
Intensity: 50–80% of HRmax
Frequency: 3 sessions/wk
Garten, 2019 RC USA Healthy males ( N = 20) Control ( N = 10): Remained sitting position for 3 h with legs stationary. Aerobic exercise ( N = 10): sit session as control; warm-up (10 min); high-intensity interval aerobic cycling exercise (28 min); sit session as control (3 h) 3 h Not described/MDA, SOD Good
Intensity: 85–95% HRmax
Goon, 2009 RP Malaysia Healthy volunteers ( N = 84) Control ( N = 44): Sedentary volunteers. Aerobic exercise ( N = 40): Tai-Chi (1 h). 24 wk, 48 wk, 24 wk Spectrometer/MDA, GPx, SOD, CAT Good
Intensity: not mentioned
Frequency: 2 times/wk
Rosado-perez, 2012 RP México Elderly subjects ( N = 55) Control ( N = 23): No intervention. Aerobic exercise ( N = 32): daily training in Tai Chi (50 min). 24 wk Other/GPx, SOD, TAS Good
Intensity: not mentioned
Frequency: 3 h-long sessions/wk
Soares, 2015 RP Portugal Healthy Caucasian men ( N = 57) Control ( N = 26): Did not undergo any physical activity. Multicomponent exercise ( N = 31): aerobic exercise (walking, running, biking, rowing, and elliptical) (25–30 min), strength exercise (bench press, leg press, leg curl, leg extension, latissimus, abdominals, and arm flexion) (30–35 min), stretching and cool down (5–10 min). 16 wk Spectrometer/MDA, TAS Good
Intensity: 75% of HR reserve (aerobic exercise); 75% of 1RM (strength exercise)
Frequency: 3 sessions/wk

aBetter methodological quality is indicated by a higher PEDro score (9–10: excellent; 6–8: good; 4–5: fair; <4: poor); significant p-values (p < 0.05) are highlighted in bold prints.

Abbreviations: CAT, catalase; Db, double blind; kcal, kilocalories; km, kilometer; GPx, glutathione peroxidase; HRmax, maximal heart rate; MDA, malondialdehyde; min, minute; RC, randomized crossover; RM, repetition maximum; RP, randomized-parallel; s, second; SB, single-blinded; SOD, superoxide dismutase; TAS, total antioxidant status; VO2max, maximal oxygen uptake; wk, week.

Table 2

Grades of recommendation, assessment, development, and evaluation (GRADE) quality of evidence

Outcome Risk of bias Inconsistency Indirectness Imprecision Publication bias Effect size Plausible residual confounding Dose–response gradient GRADE rating
MDA 0 −1a 0 0 0 0 0 0 Moderate
SOD 0 −1a 0 −1b 0 0 0 0 Low
TAS 0 −1a 0 0 0 0 0 0 Moderate
GPx 0 −1a 0 −1b 0 0 0 0 Low
CAT 0 −1a 0 −1b 0 0 0 0 Low

aSignificant and unexplained variability exists in the primary analysis. bEffect size overlaps 0 in the primary analysis. c p < 0.1 on Begg’s or Egger’s regression test. Abbreviations: CAT, catalase; GPx, glutathione peroxidase; MDA, malondialdehyde; SOD, superoxide dismutase; TAS, total antioxidant status.

3.3 Characteristics of included studies

Characteristics of studies included in this meta-analysis are shown in Table 1. The final sample consisted of 458 participants. Sample sizes ranged from 19 to 100 participants, with a median size of 42.5. Eight studies were carried out in different countries including eight countries each with a single study, and two studies in Iran. Different types of PE (aerobic exercise: six interventions; resistance exercise: three interventions; multicomponent exercise: three intervention) were evaluated in the studies.

3.4 Effect of PE on pro-oxidant biomarkers

Assessment of MDA levels was reported in eight articles including 11 interventions [27,29,30,32–34,36]. The primary meta-analysis showed that PE could significantly reduce the level of MDA (SMD −1.11, 95% CI −2.15 to −0.06). In addition, a high heterogeneity was observed among the studies (p < 0.001, I 2 = 93.9%) (Table 3 and Figure 2a). Sensitivity analyses and subgroup analyses showed that male participants, BMI < 25, exercise duration between 1 and 12 weeks, resistance exercise or multicomponent exercise, and exercise of low or moderate intensity were associated with significant PE-induced decrease in MDA concentrations (Table 3). No significant publication bias was found (Table 3). As shown in Table 3, meta-regression analysis did not identify any potential confounders.

Table 3

Results of sensitivity analysis, subgroup analysis, and publication bias stratified by study characteristics

Outcomes Interventions SMD (95% CI) P 1 Heterogeneity P 3 P 4
I 2 (%) P 2 Begg’s value Egger’s value
Pro-oxidant Interventions Net change (95% CI) P 1 I 2 (%) P 2 P 3 P 4
Begg’s value Egger’s value
MDA
Overall 11 −1.11 (−2.15, −0.06) 0.038 93.9 <0.001 1.000 0.227
Region 0.635
Conducted in Asia only 7 −0.92 (−2.80, 0.87) 0.305 95.7 <0.001 0.764 0.288
Gender −
Male only 5 −1.34 (−2.27, −0.41) 0.005 80.4 <0.001 − −
Age 0.624
<45 years 5 −1.29 (−2.14, −0.43) 0.003 74.5 0.003 − −
45–60 years 3 0.57 (−3.21, 4.36) 0.767 98.2 <0.001 − −
≥60 years 3 −2.17 (−2.59, −1.75) <0.001 0.0 0.490 − −
Baseline BMI 0.223
<25 3 −1.96 (−2.36, −1.55) <0.001 0.0 0.429 − −
>25 5 −0.51 (−2.81, 1.78) 0.660 96.9 <0.001 − −
Duration 0.974
<1 day 1 0.24 (−0.64, 1.12) 0.580 − − − −
1–12 weeks 5 −1.79 (−2.24, 1.34) <0.001 2.9 0.390 − −
>12 weeks 5 −0.62 (−2.68, 1.44) 0.551 97.2 <0.001 − −
Type of exercise 0.720
Aerobic exercise 6 −0.54 (−2.50, 1.41) 0.587 96.7 < 0.001 0.452 0.249
Resistance exercise 4 −1.95 (−2.47, −1.43) <0.001 0.0 0.450 − −
Multicomponent exercise 1 −0.90 (−1.44, −0.35) 0.001 − − − −
Intensity of exercise 0.385
Low 1 −2.02 (−2.51, −1.54) <0.001 − − − −
moderate 6 −1.65 (−2.22, −1.07) <0.001 57.7 0.037 − −
high 2 −1.02 (−3.55, 1.51) 0.430 91.7 0.001 − −
Antioxidant Interventions Net change (95% CI) P 1 I 2 (%) P 2 P 3 P 4
Begg’s value Egger’s value
SOD
Overall 8 −0.45 (−1.82, 0.93) 0.523 94.9 <0.001 0.711 0.625
Region 0.765
Conducted in Asia only 5 −0.80 (−3.28, 1.69) 0.530 96.8 <0.001 − −
Age 0.080
<45 years 4 0.80 (−0.86, 2.47) 0.344 91.5 <0.001 − −
45–60 years 2 −3.95 (−8.92, 1.02) 0.119 97.4 <0.001 − −
Baseline BMI 0.123
<25 2 2.36 (1.53, 3.18) <0.001 0 0.908 − −
>25 4 −2.77 (−5.70, 0.16) 0.064 96.2 <0.001 − −
Duration 0.037
<1 day 1 −0.50 (−1.39, 0.39) 0.272 − − − −
1∼12 weeks 5 0.86 (−0.22, 1.94) 0.118 87.4 <0.001 − −
>12 weeks 2 −3.95 (−8.92, 1.02) 0.119 97.4 <0.001 − −
Type of exercise 0.108
Aerobic exercise 5 −1.65 (−3.38, 0.08) 0.062 95.7 <0.001 − −
Resistance exercise 2 2.36 (1.53, 3.18) <0.001 0 0.908 − −
Intensity of exercise 0.849
Moderate 3 0.53 (−1.19, 2.24) 0.547 90.2 <0.001 − −
High 2 0.88 (−1.87, 3.63) 0.531 93.0 <0.001 − −
TAS 7 1.53 (0.73, 2.32) <0.001 88.9 <0.001 − −
GPx 6 0.58 (−1.06, 2.22) 0.486 95.0 <0.001 1.000 0.508
CAT 4 0.78 (−2.77, 4.34) 0.665 97.6 <0.001 − −

P 1 value for net change; P 2 value for heterogeneity in the subgroup; P 3 value for heterogeneity between groups with meta-regression, analyzed as categorical variables; P 4 value for publication bias (conducted only when trials >5); significant p-values (p < 0.05) are highlighted in bold prints.

Abbreviations: BMI, body mass index; CAT, catalase; CI, confidence interval; GPx, glutathione peroxidase; MDA, malondialdehyde; RC, randomized crossover; RP, randomized-parallel; SMD, standardized mean difference; SOD, superoxide dismutase; TAS, total antioxidant status.

Figure 2 Forest plot of the effect of PE on MDA levels (a) and antioxidants (b).
Figure 2

Forest plot of the effect of PE on MDA levels (a) and antioxidants (b).

3.5 Effect of PE on antioxidant biomarkers

SOD levels were examined in six studies [29,30,31,33–35] involving eight interventions. The results of the meta-analysis demonstrated that PE had no effect on SOD levels (SMD −0.45, 95% CI −1.82 to 0.93). There was also evidence of high heterogeneity among the studies (p < 0.001, I 2 = 94.9%) (Table 3 and Figure 2b). Significant improvements were only observed in those with baseline BMI < 25, but not in those with baseline BMI > 25. Similarly, significant improvements were only observed in those taking resistance exercise, but not in those taking aerobic exercise. Results of Begg’s and Egger’s tests did not reveal any publication bias (Table 3). Meta-regression analysis identified the age of the participants as a confounder of the effect of PE on SOD levels, with adjusted R 2 of 53.56%. Older age of subjects was associated in a gradient fashion with incident SOD levels (Table 4). TAS was assessed in six studies [27,28,30,32,35,36]. Results of meta-analysis revealed that PE significantly increased TAS levels (SMD 1.53, 95% CI 0.73–2.32), with a high heterogeneity among the studies (p < 0.001, I 2 = 88.9%) (Table 3 and Figure 2b). No significant effect was found on the levels of GPx (assesses in four studies including five trials) [32,34,35] and CAT (assessed in two studies including four trials) [30,31,34] levels (Table 3 and Figure 2b).

Table 4

Meta-regression analysis of potential moderators

Outcome Covariate Interventions (n) Coefficient 95% CI P Covariate adjusted R 2
MDA Age2 11 −0.005 −0.110 to 0.099 0.907 −
Baseline BMI2 8 0.397 −1.059 to 1.853 0.515 −
SOD Age2 7 −0.170 −0.356 to 0.166 0.065 53.56%

1Analyzed as continuous variables; 2analyzed as categorical variables; significant p-values (p < 0.05) are highlighted in bold prints.

Abbreviations: BMI, body mass index; CI, confidence interval; MDA, malondialdehyde; SOD, superoxide dismutase.

3.6 Publication bias

As shown in Table 3, based on Begg’s and Egger’s tests, there was no publication bias in all results of this meta-analysis.

4 Discussion

To the best of our knowledge, this is the first meta-analysis from ten RCTs to estimate the effect of PE on individual biomarkers of oxidative stress among healthy subjects. Overall, our results revealed that PE induced an increase in the TAS level, and reduced the level of MDA. Male participants, BMI < 25, 1–12 weeks of resistance or multicomponent exercise, and low or moderate intensity exercise were all linked to a significant drop in MDA levels caused by PE.

There was a moderate level of evidence in this study that showed that PE induced an increase in the antioxidant capacity of cells by increasing TAS levels. Furthermore, PE significantly reduced MDA levels, which is a pro-oxidant indicator. Our results are consistent with previous meta-analysis involving disease populations [37], which also revealed that any type of PE could increase the level of antioxidants and decrease the levels of pro-oxidants. Oxidative stress is caused by reduced antioxidant capacity resulting from low levels of antioxidants and reduced activity of antioxidant enzymes with or without the production of ROS [38]. Davies et al. [39] first discovered that contracted skeletal muscles produced ROS, with the production site widely assumed as mitochondria [40]. Subsequent studies demonstrated that this effect induced beneficial adaptations to oxidative stress by mediating the activation of the antioxidant system and the repair system of oxidative damage [41,42]. In general, oxidative stress is quantified by measuring the levels of pro-oxidants and antioxidants.

Our results also revealed that PE had no significant effect on levels of SOD, GPx, and CAT. Consistent with our results, a meta-analysis of animal studies showed less than 8 weeks of PE did not affect the levels of SOD, GPx, and CAT [43]. However, they also found that after more than 8 weeks of PE, the levels of SOD and CAT increased, but no significant effect was observed in the GPx level [43]. These results indicate that antioxidant enzyme expression has an adaptive response to exercise, which may be regulated by the dose of PE. Interestingly, we found that age was negatively correlated with PE-induced elevations of SOD levels. Aging is associated with increased ROS production in the skeletal muscle due to abnormal regulation of redox balance, which leads to oxidative damage [41]. At the same time, the sedentary habits and increased risk factors that develop with aging also lead to the decline in antioxidant defense ability. Consequently, the oxidative damage caused by aging may mask the effect of exercise on the circulating levels of SOD. In addition, although the primary results showed a lack of PE-induced effect on SOD levels, subgroup analysis stratified by demographic characteristics and exercise protocols showed significant effects of exercise on SOD levels. However, these results should be interpreted with caution due to the small number of studies and the unexplained heterogeneity across studies.

There are several limitations in this study. First, the included trials lacked blinding, which may have added bias. Due to the considerable heterogeneity identified among research, it is necessary to interpret our study’s findings with caution. Different experimental designs, particularly study samples, interventions, and different outcome measures, may have contributed to the substantial heterogeneity among the research. Although we addressed the cause of heterogeneity by subgroup analysis and meta-regression, the disparities in sample size between the subgroups limited some of the conclusions. Additionally, some of our subgroup analysis results exhibited publication bias, which may have compromised the validity of the reported effects.

5 Conclusions

Taken together, PE had a significant positive effect on the TAS level, and a significant negative effect on the MDA level, but no effect on the levels of SOD, GPx, and CAT. Further RCTs are required to investigate the optimal PE protocol for people of different ages and BMI.

# These authors contributed equally to this work.

  1. Funding information: Authors state no funding involved.

  2. Author contributions: Lin Shao and Yuxiao Liu conceived and designed the research, reviewed the draft of the article, and approved the final draft. Yahai Wang, Donglin Luo, and Haichao Jiang conducted research, analyzed the data, prepared figures and tables, wrote the draft of the article, and approved the final draft. Zhiqiang Wang and Yu Song analyzed the data, wrote and reviewed the draft of the article, and approved the final draft.

  3. Conflict of interest: Authors state no conflict of interest.

  4. Data availability statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Received: 2023-03-20
Revised: 2023-06-15
Accepted: 2023-07-06
Published Online: 2023-08-08

© 2023 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  250. The sequencing of the key genes and end products in the TLR4 signaling pathway from the kidney of Rana dybowskii exposed to Aeromonas hydrophila
  251. Development of a new candidate vaccine against piglet diarrhea caused by Escherichia coli
  252. Plant Sciences
  253. Crown and diameter structure of pure Pinus massoniana Lamb. forest in Hunan province, China
  254. Genetic evaluation and germplasm identification analysis on ITS2, trnL-F, and psbA-trnH of alfalfa varieties germplasm resources
  255. Tissue culture and rapid propagation technology for Gentiana rhodantha
  256. Effects of cadmium on the synthesis of active ingredients in Salvia miltiorrhiza
  257. Cloning and expression analysis of VrNAC13 gene in mung bean
  258. Chlorate-induced molecular floral transition revealed by transcriptomes
  259. Effects of warming and drought on growth and development of soybean in Hailun region
  260. Effects of different light conditions on transient expression and biomass in Nicotiana benthamiana leaves
  261. Comparative analysis of the rhizosphere microbiome and medicinally active ingredients of Atractylodes lancea from different geographical origins
  262. Distinguish Dianthus species or varieties based on chloroplast genomes
  263. Comparative transcriptomes reveal molecular mechanisms of apple blossoms of different tolerance genotypes to chilling injury
  264. Study on fresh processing key technology and quality influence of Cut Ophiopogonis Radix based on multi-index evaluation
  265. An advanced approach for fig leaf disease detection and classification: Leveraging image processing and enhanced support vector machine methodology
  266. Erratum
  267. Erratum to “Protein Z modulates the metastasis of lung adenocarcinoma cells”
  268. Erratum to “BRCA1 subcellular localization regulated by PI3K signaling pathway in triple-negative breast cancer MDA-MB-231 cells and hormone-sensitive T47D cells”
  269. Retraction
  270. Retraction to “Protocatechuic acid attenuates cerebral aneurysm formation and progression by inhibiting TNF-alpha/Nrf-2/NF-kB-mediated inflammatory mechanisms in experimental rats”
https://doi.org/10.1515/biol-2022-0668
Keywords for this article
physical exercise; oxidative stress; meta-analysis.
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  269. Retraction
  270. Retraction to “Protocatechuic acid attenuates cerebral aneurysm formation and progression by inhibiting TNF-alpha/Nrf-2/NF-kB-mediated inflammatory mechanisms in experimental rats”
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