Home Early diagnosis for the onset of peri-implantitis based on artificial neural network
Article Open Access

Early diagnosis for the onset of peri-implantitis based on artificial neural network

  • Wanting Fan , Jianming Tang , Huixia Xu , Xilin Huang , Donglei Wu and Zheng Zhang EMAIL logo
Published/Copyright: August 31, 2023
Download Article (PDF)
Open Life Sciences
From the journal Open Life Sciences Volume 18 Issue 1

Abstract

The aim of this study is to construct an artificial neural network (ANN) based on bioinformatic analysis to enable early diagnosis of peri-implantitis (PI). PI-related datasets were retrieved from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) and functional enrichment analyses were performed between PI and the control group. Furthermore, the infiltration of 22 immune cells in PI was analyzed using CIBERSORT. Hub genes were identified with random forest (RF) classification. The ANN model was then constructed for early diagnosis of PI. A total of 1,380 DEGs were identified. Enrichment analysis revealed the involvement of neutrophil-mediated immunity and the NF-kappa B signaling pathway in PI. Additionally, higher proportion of naive B cells, activated memory CD4 T cells, activated NK cells, M0 macrophages, M1 macrophages, and neutrophils were observed in the soft tissues surrounding PI. From the RF analysis, 13 hub genes (ST6GALNAC4, MTMR11, SKAP2, AKR1B1, PTGS2, CHP2, CPEB2, SYT17, GRIP1, IL10, RAB8B, ABHD5, and IGSF6) were selected. Subsequently, the ANN model for early diagnosis of PI was constructed with high performance. We identified 13 hub genes and developed an ANN model that accurately enables early diagnosis of PI.

Graphical abstract

Keywords: peri-implantitis; early diagnosis; machine learning; artificial neural network

1 Introduction

Dental implants afford great convenience to the treatment of missing teeth [1], which show great advantage in restoring functions and esthetics. However, the osseointegration of dental implants can be compromised by biological complications. One such complication is peri-implantitis (PI), which refers to the inflammation and tissue damage surrounding the implants. It is characterized by mucosal inflammation and loss of supporting bone around the implant [2]. Global implant cases have shown a high prevalence of PI, accounting for approximately 22% [3]. Currently, clinicians rely on probing and radiological examinations to diagnose PI in a clinical setting [4]. However, these methods can only detect and diagnose PI after clinical manifestations and signs have already occurred. Therefore, there is a need to identify molecular markers for PI using non-invasive methods. A recent report discovered that cyclophilins, which are increased in the peri-implant crest fluid of PI at week 2, can serve as early biomarkers for the diagnosis of PI, while the loss of supporting bone can be identified through radiological images at week 4 [5]. Hence, investigating and screening early biomarker can support the early intervention or prevention of PI. In addition, the treatment for PI is challenging. In addition, surgical treatment for PI can contribute to bone loss and post-surgical mucosal recession, which compromises the esthetic appearance [4,6]. Therefore, early diagnosis of PI is imperative. With the development of regenerative medicine, identification of hub genes related to PI may provide new information for gene-based therapies in the future [7]. In this study, we aimed to identify the hub genes associated with PI and construct an artificial neural network (ANN) model for the diagnosis of PI based on bioinformatic analysis and machine learning techniques.

2 Methods and materials

2.1 Data collection and cleaning

The gene expression matrix of PI datasets was obtained from Gene expression omnibus database (https://www.ncbi.nlm.nih.gov/geo/). A total of three datasets were enrolled in this study, including GSE106090, GSE33774, and GSE57631. Nineteen gingival tissues from patients with PI and 16 gingival tissues from healthy control were collected. After standardization and normalization, the datasets were merged and batch effects were removed using the R SVA package.

  1. Informed consent: Informed consent has been obtained from all individuals included in this study.

  2. Ethical approval: The research related to human use has been complied with all the relevant national regulations, institutional policies and in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.

2.2 Identification of differentially expressed genes (DEGs) in PI

Differential expression analysis of gingival tissues between PI and control were performed with R limma package. Genes were considered differentially expressed if they had a false discovery rate (FDR) <0.05 and a |fold change| >1.5. The DEGs expression between the PI and control groups were visualized using a heat map and a volcano plot.

2.3 Functional enrichment of DEGs between PI and control group

To further estimate the functional enrichment of DEGs between PI and control group, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were conducted with the R package (clusterProfiler) [8]. The GO (https://geneontology.org/) enrichment analysis comprises three components, including biological process (BP), molecular function (MF), and cellular component (CC). The KEGG (https://www.genome.jp/kegg/) is available for predicting the functions and utilities of the biological system based on the DEGs. The P value less than 0.05 was considered significantly difference. In addition, gene set enrichment analysis (GSEA) [9] was performed to annotate the enriched signaling pathway with GSEA software between the PI and control group. The hallmark gene sets database was downloaded from Molecular Signatures Database (h.all.v7.4.symbols.gmt) [10]. The maximum gene set size in GSEA analysis was set to 5,000 and minimum gene set size was set to 5. A P-value less than 0.05 and FDR less than 0.25 were considered statistically significant.

2.4 Immune cells infiltration between PI and control tissues based on CIBERSORT

To further evaluate the difference of immune microenvironment in peri-implant tissues between the PI and the control group, the CIBERSORT (http://cibersort.stanford.edu/) was applied to calculate 22 leukocytes infiltration in peri-implant tissues with deconvolution method [11]. The 22 leukocyte subsets include plasma cells, naïve and memory B cells, NK cells, myeloid subsets, and seven T cell types.

2.5 Identification of hub genes with random forest (RF) classification

RF classification was applied to select the hub genes from the 1,380 DEGs using the randomForest package [12]. The number of decision trees was set to 500 and the error rate was calculated for each forest. The number of optimal trees was determined based on the lowest error rate. Hub genes were evaluated by mean decreased Gini coefficient. Genes with mean deceased Gini coefficients greater than 0 were selected as hub genes. A heatmap was generated to visualize the expression of the hub genes.

2.6 Construction of diagnostic model for PI based on ANN

After normalization of the expression profiles, the selected hub genes were applied to construct the ANN based on R package (neuralnet). The merged dataset was randomly divided into a training set and a test set using the Caret package. The training set was used to calculate the weights for the hub genes in the ANN model, while the test set was used to evaluate the generalization ability of the model. The ANN model consisted of five hidden layers. The receiver operating characteristic (ROC) curve was employed to assess the sensitivity and specificity of the diagnostic ANN model for PI.

3 Results

3.1 Identification of DEGs between PI and control

After removing the batch effect, the expression of genes in the merged datasets was normalized (Figure 1a and b). A total of 14,817 genes were co-expressed in the 3 datasets (Figure 1c). Among them, 756 upregulated DEGs and 624 downregulated DEGs were identified between the PI and control groups (Figure 1d and e).

Figure 1 Data cleaning, merging, and identification of DEGs. (a) Bar plot of gene expressions in three datasets before batch effect removal. (b) Bar plot of gene expression in three datasets after batch effect removal. (c) Venn diagram of the intersection of genes from three datasets. (d) Heatmap of top 30 DEG expressions between PI and control groups. (e) Volcano plots of downregulated and upregulated genes between PI and control groups.
Figure 1

Data cleaning, merging, and identification of DEGs. (a) Bar plot of gene expressions in three datasets before batch effect removal. (b) Bar plot of gene expression in three datasets after batch effect removal. (c) Venn diagram of the intersection of genes from three datasets. (d) Heatmap of top 30 DEG expressions between PI and control groups. (e) Volcano plots of downregulated and upregulated genes between PI and control groups.

3.2 Identified functional enrichment of DEGs between PI and control group

The BP component in GO analysis indicated that neutrophil activation, neutrophil mediated immunity, leukocyte migration, and negative regulation of immune system process were the main BPs in the advance of PI. In addition, external side of plasma membrane, collagen-containing extracellular matrix, and secretory granule membrane were enriched in the CC component. Moreover, the MF component was concentrated on receptor ligand activity, cytokine activity, and cytokine receptor activity (Figure 2a). The result of KEGG analysis indicated that the cytokine−cytokine receptor interaction, PI3K−Akt signaling pathway, nuclear factor (NF)-kappa B signaling pathway, fluid shear stress, and atherosclerosis related signaling pathway, osteoclast differentiation, and leukocyte transendothelial migration signaling pathway were enriched based on the DEGs between the PI and control groups (Figure 2b). Moreover, the GSEA results demonstrated that various signaling pathways were positively correlated with the occurrence of PI. These pathways included the UV response signaling pathway, IL6/JAK/STAT3 signaling pathway, apoptosis signaling pathway, TNF-α signaling pathway via NF-Kappa B, inflammatory response signaling pathway, KRAS signaling pathway, IL2/STAT5 signaling pathway, and allograft rejection signaling pathway (Figure 2c).

Figure 2 Functional enrichment of DEGs between PI and control group. (a) Bar plot of GO enrichment analysis. The abscissa axis indicates gene number. The ordinate indicates enriched biological structure and function. BP, biological process; MF, molecular function; CC, cellular component. (b) Bubble chart of the KEGG enrichment analysis. The abscissa axis indicates the gene ratio. The ordinate indicates an enriched signaling pathway. (c) GSEA analysis of DEGs between the PI and control group.
Figure 2

Functional enrichment of DEGs between PI and control group. (a) Bar plot of GO enrichment analysis. The abscissa axis indicates gene number. The ordinate indicates enriched biological structure and function. BP, biological process; MF, molecular function; CC, cellular component. (b) Bubble chart of the KEGG enrichment analysis. The abscissa axis indicates the gene ratio. The ordinate indicates an enriched signaling pathway. (c) GSEA analysis of DEGs between the PI and control group.

3.3 Identified 22 infiltrated immune cells between PI and control tissues

The CIBERSORT results indicated a predominant infiltration of CD8 T cells, resting memory CD4 T cells, M0 macrophages, M1 macrophages, M2 macrophages, and activated mast cells in PI tissues (Figure 3a). In contrast, gingival tissues in the healthy control group were predominantly infiltrated by plasma cells, CD8 T cells, and resting memory CD4 T cells infiltration. Compared with the control group, soft tissues surrounding the PI exhibited a higher proportion of naive B cells, activated memory CD4 T cells, activated NK cells, M0 macrophages, M1 macrophages, and neutrophils, while lower level of plasma cells, resting memory CD4 T cells, and resting NK cells were identified (P < 0.05) (Figure 3b).

Figure 3 Identified 22 immune cell infiltrations between PI and control tissues. (a) Bar plot of proportion of 22 leukocytes in gingival tissues. (b) Violin plot of proportion of 22 leukocytes in gingival tissues between PI and control group.
Figure 3

Identified 22 immune cell infiltrations between PI and control tissues. (a) Bar plot of proportion of 22 leukocytes in gingival tissues. (b) Violin plot of proportion of 22 leukocytes in gingival tissues between PI and control group.

3.4 Identification of hub genes for PI based on RF classification

The RF classification was constructed with an optimal number of 12 decision trees (Figure 4a). A total of 13 hub genes were selected from the list of DEGs based on the mean decreased Gini coefficient. These hub genes included ST6GALNAC4, MTMR11, SKAP2, AKR1B1, PTGS2, CHP2, CPEB2, SYT17, GRIP1, IL10, RAB8B, ABHD5, and IGSF6 (Figure 4b). The heatmap revealed upregulation of ST6GALNAC4, AKR1B1, PTGS2, RAB8B, SKAP2, IGSF6, and IL-10 and downregulation of ABHD5, CPEB2, MTMR11, CHP2, SYT17, and GRIP1 in the PI group (Figure 4c).

Figure 4 Construction of RF classification. (a) The influence of the number of decision trees on the error rate. The x-axis indicates the number of decision trees, and the y-axis indicates the error rate. (b) The importance of DEGs based on mean decreased Gini coefficient in the RF model. (c) Heatmap of 13 hub genes expressed in PI and control tissues.
Figure 4

Construction of RF classification. (a) The influence of the number of decision trees on the error rate. The x-axis indicates the number of decision trees, and the y-axis indicates the error rate. (b) The importance of DEGs based on mean decreased Gini coefficient in the RF model. (c) Heatmap of 13 hub genes expressed in PI and control tissues.

3.5 Construction of PI diagnostic model based on ANN

The ANN employed for the diagnosis of PI consisted of 13 input layers, 5 hidden layers, and 2 output layers (Figure 5) The ANN underwent 423 iterations, with a loss function value of 0.008 and a maximum weight adjustment of 0.009. The intercept terms for the first hidden layers were sequentially −1.75, 0.84, −0.73, 0.13, and −0.43. The connecting weighting coefficients between 13 hub genes and the first hidden layers were as follows: −0.65 (ST6GALNAC4), −0.35 (MTMR11), −0.64 (SKAP2), 1.43 (AKR1B1), −0.78 (PTGS2), −0.97 (CHP2), −0.12 (CPEB2), −0.31 (SYT17), 2.24 (GRIP1), 0.08 (IL10), −1.67 (RAB8B), −0.32 (ABHD5), and 0.37 (IGSF6). In addition, a nonlinear correlation was observed between the generalized weight and impotence of 13 hub genes (Figure 6). The areas under the ROC curves (AUC) for the test set was 1, indicating a high robustness of the ANN for PI diagnosis (Figure S1).

Figure 5 Early diagnosis of PI based on ANN.
Figure 5

Early diagnosis of PI based on ANN.

Figure 6 Scatter plots of generalized weights in 13 genes.
Figure 6

Scatter plots of generalized weights in 13 genes.

4 Discussion

The fast-developing machine learning in high-throughput omics data facilitated the disease of early detection and diagnosis based on molecular profile matrices [13]. In recent years, artificial intelligence (AI) technologies have made great advances in various dental specialties. ANN, as one of the AI models, are extensively adopted in the detection and diagnosis of dental caries, salivary gland diseases, and maxillofacial cysts [14]. ANN, a type of data structure inspired by networks of biological neurons organized in layers, is widely regarded as the most efficient model for pattern recognition through automated processes [15]. The diagnostic performance of ANN has been proven to be superior to clinicians or at least comparable to that of clinicians [16]. A recent study has constructed a diagnostic ANN model with high accuracy for periodontitis [17]. Utilizing ANN applications can assist in personalized clinical decision-making, including early diagnosis, therapeutic strategy development, and prognostic assessment.

Given the increasing demand for dental implants, it is imperative to develop techniques for early diagnosis in PI. Recent researchers have constructed a risk-grading model for PI using machine learning algorithm. These models classify PI into high-risk and low-risk groups based on immune profiling, which is relevant to clinical outcomes and microbial composition [4]. In addition, risk assessment for PI using demographic data based on RF model show the best predictive performance than logistic regression and support vector machines [18]. RF predicted nearly 70% of PI cases [18]. In this study, we first constructed an ANN model with high performance for PI diagnosis based on transcriptome data, which can facilitate the clinical decision making.

Not only inflammation but also the implant itself was responsible for the alteration of immune microenvironment in gingival tissues surrounding the implant [19]. PI tends to provoke more excessive host immune responses. A recent study has identified higher macrophages infiltration in PI tissues compared to periodontitis and health control in the animal model, which was consistent with our results [19]. Macrophage polarization was involved in the development of PI lesions [20,21]. A higher level of M1 inflammatory phenotype and an increased M1/M2 ratio were observed in advanced PI tissues, which revealed an inflammation around dental implants [20]. Moreover, macrophage polarization may delay the peri-implant tissues healing after surgical therapy of PI [22]. Gingival tissues surrounding PI were characterized by an increase in the number of CD4+ T lymphocytes and B lymphocytes [23,24]. We also confirmed an increase in activated NK cells and neutrophils in tissues surrounding PI, which might regulate the hypoxia microenvironment via HIF-1α [25]. However, another research found that the immune profile with elevated M1/M2-like macrophage ratios and lower B-cell infiltration predict a lower risk for the occurrence of PI through machine learning [4].

Routine monitoring of dental implant plays an important role in preventing the occurrence of PI. However, currently there are still no standard diagnostic test for PI. Our study identified 13 hub genes of PI, which could potentially serve as key biomarkers for point-of-care testing for this condition [26]. Among the hub genes, ST6GALNAC4, a glycosyltransferase gene, plays an important role in catalyzing the transfer of sialic acid residues to the terminal positions of the glycoprotein and glycolipid carbohydrate groups. This is the first study that associates ST6GALNAC4 with PI. However, research on ST6GALNAC4 (gene or enzyme) is limited at present. A recent study found that patients with acute coronary syndrome had a lower expression of ST6GALNAC4 [27]. In addition, ST6GALNAC4 was found to be responsible for the invasion and metastasis in follicular thyroid cancer [28]. Interleukin (IL)-10 was closely related to the development of PI [29,30]. Several published studies have reported an increase in IL-10 expression [31,32,33]. However, another study demonstrated a negative correlation between IL-10 levels and the peri-implant probing depth in PI [30]. Consistent with the findings of Bressan et al. [34], increased expression of prostaglandin-endoperoxide synthase 2 (PTGS2) was observed in PI tissues. The protein-coding gene IGSF6, belonging to the immunoglobulin superfamily member 6, is involved in the regulation of inflammatory bowel disease [35]. Multiple hub genes were associated with the regulation of inflammation and immune metabolism, suggesting a significant role in the onset of PI. SKAP2, a gene encoding Src kinase-associated phosphoprotein 2, is responsible for B-cell and macrophage adhesion processes. Aldose reductase (AKR1B1) is a NADPH-dependent aldo-keto reductase involved in polyol biosynthesis [36]. However, the reduction of aldehydes which was catalyzed by AKR1B1 enabled the activation of intracellular inflammatory via the NF-κB signaling pathway [37]. The NF-κB signaling pathway in macrophages is considered critical for the pathological mechanisms of PI. The abhydrolase domain containing 5 (ABHD5), an activator of triglyceride hydrolysis in macrophages, plays a crucial role in inflammation resolution and metabolic reprogramming in cancer. ABHD5 suppressed the excessive production of reactive oxygen species and pro-inflammatory cytokines by inhibiting the activation of NLRP3 inflammasome in macrophages [38]. In addition, ABHD5 exhibits low expression in migratory tumor-associated macrophages. Recent research has indicated that ABHD5 in macrophages inhibited the production of matrix metalloproteinases (MMP) in an NF-κB-dependent manner, effectively reducing colorectal cancer metastasis [39]. Similarly, CHP2 was identified to reduce oxidative damage and restrain the activation of NF-κB-p65 [40]. GRIP1, an essential regulator of immunometabolism, engaged in modulating the macrophage polarization and maintaining the metabolic homeostasis [36].

The primary limitation of this study is the small sample size. Machine learning algorithms heavily rely on large datasets for learning and training. Limited data in training set and test set could increase the risk of overfitting in the ANN model [41]. Furthermore, the study did not have access to clinical and imaging characteristics from public databases. Only the PI transcriptome was included in construction of diagnostic model, neglecting the involvement of genetic, epigenetic, and environmental factors in the onset of PI [42]. Notably, hypermethylation and titanium dissolution particles have been linked to the development of PI [42]. Therefore, the value of ANN diagnostic model for PI requires further validation using larger sample sizes and multiple omics data.

5 Conclusion

In summary, we identified 13 hub genes and constructed the ANN model for the early diagnosis of PI, which is imperative for personalized clinical decision making. Further works are needed to verify those genes’ functions for PI.

# Both authors contributed equally to this work.

  1. Funding information: The study was supported by the Shenzhen People’s Hospital for young and middle-aged Co-PI foster project (SYJCYJ202105).

  2. Author contributions: Fan W.T. and Zhang Z. designed the study and wrote the original draft preparation. Tang J.M. and Xu H.X. managed and coordinated the research. Huang X.L. collected the data. Wu D.L. conducted the bioinformatic analysis and visualization. All authors reviewed the manuscript.

  3. Conflict of interest: Authors state no conflict of interest.

  4. Data availability statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

[1] Elani HW, Starr JR, Da Silva JD, Gallucci GO. Trends in dental implant use in the U.S., 1999–2016, and Projections to 2026. J Dent Res. 2018;97(13):1424–30. Epub 2018/08/04.10.1177/0022034518792567Search in Google Scholar PubMed PubMed Central

[2] Schwarz F, Derks J, Monje A, Wang HL. Peri-implantitis. J Periodontol. 2018;89(Suppl 1):S267–90. Epub 2018/06/22.10.1002/JPER.16-0350Search in Google Scholar PubMed

[3] Roccuzzo A, Stahli A, Monje A, Sculean A, Salvi GE. Peri-implantitis: A clinical update on prevalence and surgical treatment outcomes. J Clin Med. 2021;10(5):1107. Epub 2021/04/04.10.3390/jcm10051107Search in Google Scholar PubMed PubMed Central

[4] Wang CW, Hao Y, Di Gianfilippo R, Sugai J, Li J, Gong W, et al. Machine learning-assisted immune profiling stratifies peri-implantitis patients with unique microbial colonization and clinical outcomes. Theranostics. 2021;11(14):6703–16. Epub 2021/06/08.10.7150/thno.57775Search in Google Scholar PubMed PubMed Central

[5] Yang L, Zhu Q, Gong J, Xie M, Jiao T. CyPA and Emmprin play a role in peri-implantitis. Clin Implant Dent Relat Res. 2018;20(2):102–9. Epub 2017/10/24.10.1111/cid.12549Search in Google Scholar PubMed

[6] Schwarz F, Alcoforado G, Guerrero A, Jonsson D, Klinge B, Lang N, et al. Peri-implantitis: Summary and consensus statements of group 3. The 6th EAO Consensus Conference 2021. Clin Oral Implants Res. 2021;32(Suppl 21). p. 245–53. Epub 2021/10/14.10.1111/clr.13827Search in Google Scholar PubMed

[7] Goker F, Larsson L, Del Fabbro M, Asa’ad F. Gene delivery therapeutics in the treatment of periodontitis and peri-implantitis: A state of the art review. Int J Mol Sci. 2019;20(14):3551. Epub 2019/07/25.10.3390/ijms20143551Search in Google Scholar PubMed PubMed Central

[8] Yu G, Wang LG, Han Y, He QY. clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–7. Epub 2012/03/30.10.1089/omi.2011.0118Search in Google Scholar PubMed PubMed Central

[9] Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545–50. Epub 2005/10/04.10.1073/pnas.0506580102Search in Google Scholar PubMed PubMed Central

[10] Liberzon A, Subramanian A, Pinchback R, Thorvaldsdottir H, Tamayo P, Mesirov JP. Molecular signatures database (MSigDB) 3.0. Bioinformatics. 2011;27(12):1739–40. Epub. 2011/05/07.10.1093/bioinformatics/btr260Search in Google Scholar PubMed PubMed Central

[11] Newman AM, Liu CL, Green MR, Gentles AJ, Feng W, Xu Y, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12(5):453–7. Epub 2015/03/31.10.1038/nmeth.3337Search in Google Scholar PubMed PubMed Central

[12] Liaw A. Package randomForest: Breiman and Cutler’s Random forest for classification and regression. CRAN Repository; 2006. http://cran r-project org/web/packages/randomForest/randomForest pdf.Search in Google Scholar

[13] Yu H, Samuels DC, Zhao YY, Guo Y. Architectures and accuracy of artificial neural network for disease classification from omics data. BMC Genomics. 2019;20(1):167. Epub 2019/03/06.10.1186/s12864-019-5546-zSearch in Google Scholar PubMed PubMed Central

[14] Khanagar SB, Al-Ehaideb A, Maganur PC, Vishwanathaiah S, Patil S, Baeshen HA, et al. Developments, application, and performance of artificial intelligence in dentistry - A systematic review. J Dent Sci. 2021;16(1):508–22. Epub 2021/01/02.10.1016/j.jds.2020.06.019Search in Google Scholar PubMed PubMed Central

[15] Jhalia V, Swarnkar T. A Critical Review on the Application of Artificial Neural Network in Bioinformatics. Data Analytics in Bioinformatics: A Machine Learning Perspective. Wiley; 2021. p. 51–76.10.1002/9781119785620.ch3Search in Google Scholar

[16] Han SS, Moon IJ, Kim SH, Na JI, Kim MS, Park GH, et al. Assessment of deep neural networks for the diagnosis of benign and malignant skin neoplasms in comparison with dermatologists: A retrospective validation study. PLoS Med. 2020;17(11):e1003381. Epub 2020/11/26.10.1371/journal.pmed.1003381Search in Google Scholar PubMed PubMed Central

[17] Xiang J, Huang W, He Y, Li Y, Wang Y, Chen R. Construction of artificial neural network diagnostic model and analysis of immune infiltration for periodontitis. Front Genet. 2022;13:1041524.10.3389/fgene.2022.1041524Search in Google Scholar PubMed PubMed Central

[18] Mameno T, Wada M, Nozaki K, Takahashi T, Tsujioka Y, Akema S, et al. Predictive modeling for peri-implantitis by using machine learning techniques. Sci Rep. 2021;11(1):11090. Epub 2021/05/29.10.1038/s41598-021-90642-4Search in Google Scholar PubMed PubMed Central

[19] Yuan S, Wang C, Jiang W, Wei Y, Li Q, Song Z, et al. Comparative transcriptome analysis of gingival immune-mediated inflammation in peri-implantitis and periodontitis within the same host environment. J Inflamm Res. 2022;15:3119–33. Epub 2022/06/02.10.2147/JIR.S363538Search in Google Scholar PubMed PubMed Central

[20] Galarraga-Vinueza ME, Obreja K, Ramanauskaite A, Magini R, Begic A, Sader R, et al. Macrophage polarization in peri-implantitis lesions. Clin Oral Investig. 2021;25(4):2335–44. Epub 2020/09/05.10.1007/s00784-020-03556-2Search in Google Scholar PubMed PubMed Central

[21] Fretwurst T, Garaicoa-Pazmino C, Nelson K, Giannobile WV, Squarize CH, Larsson L, et al. Characterization of macrophages infiltrating peri-implantitis lesions. Clin Oral Implants Res. 2020;31(3):274–81. Epub 2019/12/27.10.1111/clr.13568Search in Google Scholar PubMed

[22] Galarraga-Vinueza ME, Obreja K, Khoury C, Begic A, Ramanauskaite A, Sculean A, et al. Influence of macrophage polarization on the effectiveness of surgical therapy of peri-implantitis. Int J Implant Dent. 2021;7(1):110. Epub 2021/11/13.10.1186/s40729-021-00391-2Search in Google Scholar PubMed PubMed Central

[23] Talarico GM, Neiders ME, Comeau RL, Cohen RE. Phenotypic characterization of mononuclear cells from gingiva associated with periodontitis and peri-implantitis. J Oral Implantol. 1997;23(1–2):5–11. Epub 1997/01/01.Search in Google Scholar

[24] Gualini F, Berglundh T. Immunohistochemical characteristics of inflammatory lesions at implants. J Clin Periodontol. 2003;30(1):14–8. Epub 2003/04/19.10.1034/j.1600-051X.2003.300103.xSearch in Google Scholar

[25] de Araujo MF, Etchebehere RM, de Melo MLR, Beghini M, Severino VO, de Castro Cobo E, et al. Analysis of CD15, CD57 and HIF-1alpha in biopsies of patients with peri-implantitis. Pathol Res Pract. 2017;213(9):1097–101. Epub 2017/08/06.10.1016/j.prp.2017.07.020Search in Google Scholar PubMed

[26] Bornes R, Montero J, Correia A, Marques T, Rosa N. Peri-implant diseases diagnosis, prognosis and dental implant monitoring: a narrative review of novel strategies and clinical impact. BMC Oral Health. 2023;23(1):1–7.10.1186/s12903-023-02896-1Search in Google Scholar PubMed PubMed Central

[27] Hadzibegovic I, Vrselja Z, Lauc G, Curic G. Expression of leukocyte adhesion-related glycosyltransferase genes in acute coronary syndrome patients. Inflamm Res. 2014;63(8):629–36. Epub 2014/04/22.10.1007/s00011-014-0735-3Search in Google Scholar PubMed

[28] Miao X, Jia L, Zhou H, Song X, Zhou M, Xu J, et al. miR-4299 mediates the invasive properties and tumorigenicity of human follicular thyroid carcinoma by targeting ST6GALNAC4. IUBMB Life. 2016;68(2):136–44. Epub 2015/12/31.10.1002/iub.1467Search in Google Scholar PubMed

[29] Jamshidy L, Tadakamadla SK, Choubsaz P, Sadeghi M, Tadakamadla J. Association of IL-10 and TNF-alpha polymorphisms with dental peri-implant disease risk: A meta-analysis, meta-regression, and trial sequential analysis. Int J Environ Res Public Health. 2021;18(14):7697. Epub 2021/07/25.10.3390/ijerph18147697Search in Google Scholar PubMed PubMed Central

[30] Blanco C, Linares A, Dopico J, Pico A, Sobrino T, Leira Y, et al. Peri-implantitis, systemic inflammation, and dyslipidemia: a cross-sectional biochemical study. J Periodontal Implant Sci. 2021;51(5):342–51. Epub 2021/10/30.10.5051/jpis.2100920046Search in Google Scholar PubMed PubMed Central

[31] Ata-Ali J, Flichy-Fernandez AJ, Alegre-Domingo T, Ata-Ali F, Palacio J, Penarrocha-Diago M. Clinical, microbiological, and immunological aspects of healthy versus peri-implantitis tissue in full arch reconstruction patients: a prospective cross-sectional study. BMC Oral Health. 2015;15:43. Epub 2015/04/19.10.1186/s12903-015-0031-9Search in Google Scholar PubMed PubMed Central

[32] Casado PL, Canullo L, de Almeida Filardy A, Granjeiro JM, Barboza EP, Leite Duarte ME. Interleukins 1β and 10 expressions in the periimplant crevicular fluid from patients with untreated periimplant disease. Implant Dent. 2013;22(2):143–50. Epub 2013/03/06.10.1097/ID.0b013e3182818792Search in Google Scholar PubMed

[33] Ghighi M, Llorens A, Baroukh B, Chaussain C, Bouchard P, Gosset M. Differences between inflammatory and catabolic mediators of peri-implantitis and periodontitis lesions following initial mechanical therapy: An exploratory study. J Periodontal Res. 2018;53(1):29–39. Epub 2017/09/13.10.1111/jre.12483Search in Google Scholar PubMed

[34] Bressan E, Ferroni L, Gardin C, Bellin G, Sbricoli L, Sivolella S, et al. Metal nanoparticles released from dental implant surfaces: Potential contribution to chronic inflammation and peri-implant bone loss. Materials (Basel). 2019;12(12):2036. Epub 2019/06/28.10.3390/ma12122036Search in Google Scholar PubMed PubMed Central

[35] King K, Moody A, Fisher SA, Mirza MM, Cuthbert AP, Hampe J, et al. Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease. Eur J Immunogenet. 2003;30(3):187–90. Epub 2003/06/06.10.1046/j.1365-2370.2003.00387.xSearch in Google Scholar PubMed

[36] Coppo M, Chinenov Y, Sacta MA, Rogatsky I. The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis. Nat Commun. 2016;7:12254. Epub 2016/07/29.10.1038/ncomms12254Search in Google Scholar PubMed PubMed Central

[37] Milackova I, Kapustova K, Mucaji P, Hosek J. Artichoke leaf extract inhibits AKR1B1 and reduces NF-kappaB activity in human leukemic cells. Phytother Res. 2017;31(0033):488–96. Epub 2017/01/28.10.1002/ptr.5774Search in Google Scholar PubMed

[38] Miao H, Ou J, Ma Y, Guo F, Yang Z, Wiggins M, et al. Macrophage CGI-58 deficiency activates ROS-inflammasome pathway to promote insulin resistance in mice. Cell Rep. 2014;7(1):223–35. Epub 2014/04/08.10.1016/j.celrep.2014.02.047Search in Google Scholar PubMed PubMed Central

[39] Shang S, Ji X, Zhang L, Chen J, Li C, Shi R, et al. Macrophage ABHD5 suppresses NFkappaB-dependent matrix metalloproteinase expression and cancer metastasis. Cancer Res. 2019;79(21):5513–26. Epub 2019/08/24.10.1158/0008-5472.CAN-19-1059Search in Google Scholar PubMed

[40] Cai B, Wan P, Chen H, Chen D, Chen X, Sun H, et al. Composition characterization of oyster polysaccharides from Crassostrea hongkongensis and their protective effect against H2O2-induced oxidative damage in IEC-6 cells. Int J Biol Macromol. 2019;124:246–54. Epub 2018/11/20.10.1016/j.ijbiomac.2018.11.154Search in Google Scholar PubMed

[41] Bonatti C, Mohr D. One for all: Universal material model based on minimal state-space neural networks. Sci Adv. 2021;7(26):eabf3658. Epub 2021/06/25.10.1126/sciadv.abf3658Search in Google Scholar PubMed PubMed Central

[42] Daubert DM, Pozhitkov AE, Safioti LM, Kotsakis GA. Association of global DNA methylation to titanium and peri-implantitis: A case-control study. JDR Clin Trans Res. 2019;4(3):284–91. Epub 2019/04/02.10.1177/2380084418822831Search in Google Scholar PubMed

Received: 2023-05-24
Revised: 2023-07-16
Accepted: 2023-07-29
Published Online: 2023-08-31

© 2023 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Articles in the same Issue

  1. Biomedical Sciences
  2. Systemic investigation of inetetamab in combination with small molecules to treat HER2-overexpressing breast and gastric cancers
  3. Immunosuppressive treatment for idiopathic membranous nephropathy: An updated network meta-analysis
  4. Identifying two pathogenic variants in a patient with pigmented paravenous retinochoroidal atrophy
  5. Effects of phytoestrogens combined with cold stress on sperm parameters and testicular proteomics in rats
  6. A case of pulmonary embolism with bad warfarin anticoagulant effects caused by E. coli infection
  7. Neutrophilia with subclinical Cushing’s disease: A case report and literature review
  8. Isoimperatorin alleviates lipopolysaccharide-induced periodontitis by downregulating ERK1/2 and NF-κB pathways
  9. Immunoregulation of synovial macrophages for the treatment of osteoarthritis
  10. Novel CPLANE1 c.8948dupT (p.P2984Tfs*7) variant in a child patient with Joubert syndrome
  11. Antiphospholipid antibodies and the risk of thrombosis in myeloproliferative neoplasms
  12. Immunological responses of septic rats to combination therapy with thymosin α1 and vitamin C
  13. High glucose and high lipid induced mitochondrial dysfunction in JEG-3 cells through oxidative stress
  14. Pharmacological inhibition of the ubiquitin-specific protease 8 effectively suppresses glioblastoma cell growth
  15. Levocarnitine regulates the growth of angiotensin II-induced myocardial fibrosis cells via TIMP-1
  16. Age-related changes in peripheral T-cell subpopulations in elderly individuals: An observational study
  17. Single-cell transcription analysis reveals the tumor origin and heterogeneity of human bilateral renal clear cell carcinoma
  18. Identification of iron metabolism-related genes as diagnostic signatures in sepsis by blood transcriptomic analysis
  19. Long noncoding RNA ACART knockdown decreases 3T3-L1 preadipocyte proliferation and differentiation
  20. Surgery, adjuvant immunotherapy plus chemotherapy and radiotherapy for primary malignant melanoma of the parotid gland (PGMM): A case report
  21. Dosimetry comparison with helical tomotherapy, volumetric modulated arc therapy, and intensity-modulated radiotherapy for grade II gliomas: A single‑institution case series
  22. Soy isoflavone reduces LPS-induced acute lung injury via increasing aquaporin 1 and aquaporin 5 in rats
  23. Refractory hypokalemia with sexual dysplasia and infertility caused by 17α-hydroxylase deficiency and triple X syndrome: A case report
  24. Meta-analysis of cancer risk among end stage renal disease undergoing maintenance dialysis
  25. 6-Phosphogluconate dehydrogenase inhibition arrests growth and induces apoptosis in gastric cancer via AMPK activation and oxidative stress
  26. Experimental study on the optimization of ANM33 release in foam cells
  27. Primary retroperitoneal angiosarcoma: A case report
  28. Metabolomic analysis-identified 2-hydroxybutyric acid might be a key metabolite of severe preeclampsia
  29. Malignant pleural effusion diagnosis and therapy
  30. Effect of spaceflight on the phenotype and proteome of Escherichia coli
  31. Comparison of immunotherapy combined with stereotactic radiotherapy and targeted therapy for patients with brain metastases: A systemic review and meta-analysis
  32. Activation of hypermethylated P2RY1 mitigates gastric cancer by promoting apoptosis and inhibiting proliferation
  33. Association between the VEGFR-2 -604T/C polymorphism (rs2071559) and type 2 diabetic retinopathy
  34. The role of IL-31 and IL-34 in the diagnosis and treatment of chronic periodontitis
  35. Triple-negative mouse breast cancer initiating cells show high expression of beta1 integrin and increased malignant features
  36. mNGS facilitates the accurate diagnosis and antibiotic treatment of suspicious critical CNS infection in real practice: A retrospective study
  37. The apatinib and pemetrexed combination has antitumor and antiangiogenic effects against NSCLC
  38. Radiotherapy for primary thyroid adenoid cystic carcinoma
  39. Design and functional preliminary investigation of recombinant antigen EgG1Y162–EgG1Y162 against Echinococcus granulosus
  40. Effects of losartan in patients with NAFLD: A meta-analysis of randomized controlled trial
  41. Bibliometric analysis of METTL3: Current perspectives, highlights, and trending topics
  42. Performance comparison of three scaling algorithms in NMR-based metabolomics analysis
  43. PI3K/AKT/mTOR pathway and its related molecules participate in PROK1 silence-induced anti-tumor effects on pancreatic cancer
  44. The altered expression of cytoskeletal and synaptic remodeling proteins during epilepsy
  45. Effects of pegylated recombinant human granulocyte colony-stimulating factor on lymphocytes and white blood cells of patients with malignant tumor
  46. Prostatitis as initial manifestation of Chlamydia psittaci pneumonia diagnosed by metagenome next-generation sequencing: A case report
  47. NUDT21 relieves sevoflurane-induced neurological damage in rats by down-regulating LIMK2
  48. Association of interleukin-10 rs1800896, rs1800872, and interleukin-6 rs1800795 polymorphisms with squamous cell carcinoma risk: A meta-analysis
  49. Exosomal HBV-DNA for diagnosis and treatment monitoring of chronic hepatitis B
  50. Shear stress leads to the dysfunction of endothelial cells through the Cav-1-mediated KLF2/eNOS/ERK signaling pathway under physiological conditions
  51. Interaction between the PI3K/AKT pathway and mitochondrial autophagy in macrophages and the leukocyte count in rats with LPS-induced pulmonary infection
  52. Meta-analysis of the rs231775 locus polymorphism in the CTLA-4 gene and the susceptibility to Graves’ disease in children
  53. Cloning, subcellular localization and expression of phosphate transporter gene HvPT6 of hulless barley
  54. Coptisine mitigates diabetic nephropathy via repressing the NRLP3 inflammasome
  55. Significant elevated CXCL14 and decreased IL-39 levels in patients with tuberculosis
  56. Whole-exome sequencing applications in prenatal diagnosis of fetal bowel dilatation
  57. Gemella morbillorum infective endocarditis: A case report and literature review
  58. An unusual ectopic thymoma clonal evolution analysis: A case report
  59. Severe cumulative skin toxicity during toripalimab combined with vemurafenib following toripalimab alone
  60. Detection of V. vulnificus septic shock with ARDS using mNGS
  61. Novel rare genetic variants of familial and sporadic pulmonary atresia identified by whole-exome sequencing
  62. The influence and mechanistic action of sperm DNA fragmentation index on the outcomes of assisted reproduction technology
  63. Novel compound heterozygous mutations in TELO2 in an infant with You-Hoover-Fong syndrome: A case report and literature review
  64. ctDNA as a prognostic biomarker in resectable CLM: Systematic review and meta-analysis
  65. Diagnosis of primary amoebic meningoencephalitis by metagenomic next-generation sequencing: A case report
  66. Phylogenetic analysis of promoter regions of human Dolichol kinase (DOLK) and orthologous genes using bioinformatics tools
  67. Collagen changes in rabbit conjunctiva after conjunctival crosslinking
  68. Effects of NM23 transfection of human gastric carcinoma cells in mice
  69. Oral nifedipine and phytosterol, intravenous nicardipine, and oral nifedipine only: Three-arm, retrospective, cohort study for management of severe preeclampsia
  70. Case report of hepatic retiform hemangioendothelioma: A rare tumor treated with ultrasound-guided microwave ablation
  71. Curcumin induces apoptosis in human hepatocellular carcinoma cells by decreasing the expression of STAT3/VEGF/HIF-1α signaling
  72. Rare presentation of double-clonal Waldenström macroglobulinemia with pulmonary embolism: A case report
  73. Giant duplication of the transverse colon in an adult: A case report and literature review
  74. Ectopic thyroid tissue in the breast: A case report
  75. SDR16C5 promotes proliferation and migration and inhibits apoptosis in pancreatic cancer
  76. Vaginal metastasis from breast cancer: A case report
  77. Screening of the best time window for MSC transplantation to treat acute myocardial infarction with SDF-1α antibody-loaded targeted ultrasonic microbubbles: An in vivo study in miniswine
  78. Inhibition of TAZ impairs the migration ability of melanoma cells
  79. Molecular complexity analysis of the diagnosis of Gitelman syndrome in China
  80. Effects of maternal calcium and protein intake on the development and bone metabolism of offspring mice
  81. Identification of winter wheat pests and diseases based on improved convolutional neural network
  82. Ultra-multiplex PCR technique to guide treatment of Aspergillus-infected aortic valve prostheses
  83. Virtual high-throughput screening: Potential inhibitors targeting aminopeptidase N (CD13) and PIKfyve for SARS-CoV-2
  84. Immune checkpoint inhibitors in cancer patients with COVID-19
  85. Utility of methylene blue mixed with autologous blood in preoperative localization of pulmonary nodules and masses
  86. Integrated analysis of the microbiome and transcriptome in stomach adenocarcinoma
  87. Berberine suppressed sarcopenia insulin resistance through SIRT1-mediated mitophagy
  88. DUSP2 inhibits the progression of lupus nephritis in mice by regulating the STAT3 pathway
  89. Lung abscess by Fusobacterium nucleatum and Streptococcus spp. co-infection by mNGS: A case series
  90. Genetic alterations of KRAS and TP53 in intrahepatic cholangiocarcinoma associated with poor prognosis
  91. Granulomatous polyangiitis involving the fourth ventricle: Report of a rare case and a literature review
  92. Studying infant mortality: A demographic analysis based on data mining models
  93. Metaplastic breast carcinoma with osseous differentiation: A report of a rare case and literature review
  94. Protein Z modulates the metastasis of lung adenocarcinoma cells
  95. Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro
  96. TAK-242, a toll-like receptor 4 antagonist, against brain injury by alleviates autophagy and inflammation in rats
  97. Primary mediastinum Ewing’s sarcoma with pleural effusion: A case report and literature review
  98. Association of ADRB2 gene polymorphisms and intestinal microbiota in Chinese Han adolescents
  99. Tanshinone IIA alleviates chondrocyte apoptosis and extracellular matrix degeneration by inhibiting ferroptosis
  100. Study on the cytokines related to SARS-Cov-2 in testicular cells and the interaction network between cells based on scRNA-seq data
  101. Effect of periostin on bone metabolic and autophagy factors during tooth eruption in mice
  102. HP1 induces ferroptosis of renal tubular epithelial cells through NRF2 pathway in diabetic nephropathy
  103. Intravaginal estrogen management in postmenopausal patients with vaginal squamous intraepithelial lesions along with CO2 laser ablation: A retrospective study
  104. Hepatocellular carcinoma cell differentiation trajectory predicts immunotherapy, potential therapeutic drugs, and prognosis of patients
  105. Effects of physical exercise on biomarkers of oxidative stress in healthy subjects: A meta-analysis of randomized controlled trials
  106. Identification of lysosome-related genes in connection with prognosis and immune cell infiltration for drug candidates in head and neck cancer
  107. Development of an instrument-free and low-cost ELISA dot-blot test to detect antibodies against SARS-CoV-2
  108. Research progress on gas signal molecular therapy for Parkinson’s disease
  109. Adiponectin inhibits TGF-β1-induced skin fibroblast proliferation and phenotype transformation via the p38 MAPK signaling pathway
  110. The G protein-coupled receptor-related gene signatures for predicting prognosis and immunotherapy response in bladder urothelial carcinoma
  111. α-Fetoprotein contributes to the malignant biological properties of AFP-producing gastric cancer
  112. CXCL12/CXCR4/CXCR7 axis in placenta tissues of patients with placenta previa
  113. Association between thyroid stimulating hormone levels and papillary thyroid cancer risk: A meta-analysis
  114. Significance of sTREM-1 and sST2 combined diagnosis for sepsis detection and prognosis prediction
  115. Diagnostic value of serum neuroactive substances in the acute exacerbation of chronic obstructive pulmonary disease complicated with depression
  116. Research progress of AMP-activated protein kinase and cardiac aging
  117. TRIM29 knockdown prevented the colon cancer progression through decreasing the ubiquitination levels of KRT5
  118. Cross-talk between gut microbiota and liver steatosis: Complications and therapeutic target
  119. Metastasis from small cell lung cancer to ovary: A case report
  120. The early diagnosis and pathogenic mechanisms of sepsis-related acute kidney injury
  121. The effect of NK cell therapy on sepsis secondary to lung cancer: A case report
  122. Erianin alleviates collagen-induced arthritis in mice by inhibiting Th17 cell differentiation
  123. Loss of ACOX1 in clear cell renal cell carcinoma and its correlation with clinical features
  124. Signalling pathways in the osteogenic differentiation of periodontal ligament stem cells
  125. Crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failure
  126. Clinicopathological features and differential diagnosis of gastric pleomorphic giant cell carcinoma
  127. Traumatic brain injury and rTMS-ERPs: Case report and literature review
  128. Extracellular fibrin promotes non-small cell lung cancer progression through integrin β1/PTEN/AKT signaling
  129. Knockdown of DLK4 inhibits non-small cell lung cancer tumor growth by downregulating CKS2
  130. The co-expression pattern of VEGFR-2 with indicators related to proliferation, apoptosis, and differentiation of anagen hair follicles
  131. Inflammation-related signaling pathways in tendinopathy
  132. CD4+ T cell count in HIV/TB co-infection and co-occurrence with HL: Case report and literature review
  133. Clinical analysis of severe Chlamydia psittaci pneumonia: Case series study
  134. Bioinformatics analysis to identify potential biomarkers for the pulmonary artery hypertension associated with the basement membrane
  135. Influence of MTHFR polymorphism, alone or in combination with smoking and alcohol consumption, on cancer susceptibility
  136. Catharanthus roseus (L.) G. Don counteracts the ampicillin resistance in multiple antibiotic-resistant Staphylococcus aureus by downregulation of PBP2a synthesis
  137. Combination of a bronchogenic cyst in the thoracic spinal canal with chronic myelocytic leukemia
  138. Bacterial lipoprotein plays an important role in the macrophage autophagy and apoptosis induced by Salmonella typhimurium and Staphylococcus aureus
  139. TCL1A+ B cells predict prognosis in triple-negative breast cancer through integrative analysis of single-cell and bulk transcriptomic data
  140. Ezrin promotes esophageal squamous cell carcinoma progression via the Hippo signaling pathway
  141. Ferroptosis: A potential target of macrophages in plaque vulnerability
  142. Predicting pediatric Crohn's disease based on six mRNA-constructed risk signature using comprehensive bioinformatic approaches
  143. Applications of genetic code expansion and photosensitive UAAs in studying membrane proteins
  144. HK2 contributes to the proliferation, migration, and invasion of diffuse large B-cell lymphoma cells by enhancing the ERK1/2 signaling pathway
  145. IL-17 in osteoarthritis: A narrative review
  146. Circadian cycle and neuroinflammation
  147. Probiotic management and inflammatory factors as a novel treatment in cirrhosis: A systematic review and meta-analysis
  148. Hemorrhagic meningioma with pulmonary metastasis: Case report and literature review
  149. SPOP regulates the expression profiles and alternative splicing events in human hepatocytes
  150. Knockdown of SETD5 inhibited glycolysis and tumor growth in gastric cancer cells by down-regulating Akt signaling pathway
  151. PTX3 promotes IVIG resistance-induced endothelial injury in Kawasaki disease by regulating the NF-κB pathway
  152. Pancreatic ectopic thyroid tissue: A case report and analysis of literature
  153. The prognostic impact of body mass index on female breast cancer patients in underdeveloped regions of northern China differs by menopause status and tumor molecular subtype
  154. Report on a case of liver-originating malignant melanoma of unknown primary
  155. Case report: Herbal treatment of neutropenic enterocolitis after chemotherapy for breast cancer
  156. The fibroblast growth factor–Klotho axis at molecular level
  157. Characterization of amiodarone action on currents in hERG-T618 gain-of-function mutations
  158. A case report of diagnosis and dynamic monitoring of Listeria monocytogenes meningitis with NGS
  159. Effect of autologous platelet-rich plasma on new bone formation and viability of a Marburg bone graft
  160. Small breast epithelial mucin as a useful prognostic marker for breast cancer patients
  161. Continuous non-adherent culture promotes transdifferentiation of human adipose-derived stem cells into retinal lineage
  162. Nrf3 alleviates oxidative stress and promotes the survival of colon cancer cells by activating AKT/BCL-2 signal pathway
  163. Favorable response to surufatinib in a patient with necrolytic migratory erythema: A case report
  164. Case report of atypical undernutrition of hypoproteinemia type
  165. Down-regulation of COL1A1 inhibits tumor-associated fibroblast activation and mediates matrix remodeling in the tumor microenvironment of breast cancer
  166. Sarcoma protein kinase inhibition alleviates liver fibrosis by promoting hepatic stellate cells ferroptosis
  167. Research progress of serum eosinophil in chronic obstructive pulmonary disease and asthma
  168. Clinicopathological characteristics of co-existing or mixed colorectal cancer and neuroendocrine tumor: Report of five cases
  169. Role of menopausal hormone therapy in the prevention of postmenopausal osteoporosis
  170. Precisional detection of lymph node metastasis using tFCM in colorectal cancer
  171. Advances in diagnosis and treatment of perimenopausal syndrome
  172. A study of forensic genetics: ITO index distribution and kinship judgment between two individuals
  173. Acute lupus pneumonitis resembling miliary tuberculosis: A case-based review
  174. Plasma levels of CD36 and glutathione as biomarkers for ruptured intracranial aneurysm
  175. Fractalkine modulates pulmonary angiogenesis and tube formation by modulating CX3CR1 and growth factors in PVECs
  176. Novel risk prediction models for deep vein thrombosis after thoracotomy and thoracoscopic lung cancer resections, involving coagulation and immune function
  177. Exploring the diagnostic markers of essential tremor: A study based on machine learning algorithms
  178. Evaluation of effects of small-incision approach treatment on proximal tibia fracture by deep learning algorithm-based magnetic resonance imaging
  179. An online diagnosis method for cancer lesions based on intelligent imaging analysis
  180. Medical imaging in rheumatoid arthritis: A review on deep learning approach
  181. Predictive analytics in smart healthcare for child mortality prediction using a machine learning approach
  182. Utility of neutrophil–lymphocyte ratio and platelet–lymphocyte ratio in predicting acute-on-chronic liver failure survival
  183. A biomedical decision support system for meta-analysis of bilateral upper-limb training in stroke patients with hemiplegia
  184. TNF-α and IL-8 levels are positively correlated with hypobaric hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats
  185. Stochastic gradient descent optimisation for convolutional neural network for medical image segmentation
  186. Comparison of the prognostic value of four different critical illness scores in patients with sepsis-induced coagulopathy
  187. Application and teaching of computer molecular simulation embedded technology and artificial intelligence in drug research and development
  188. Hepatobiliary surgery based on intelligent image segmentation technology
  189. Value of brain injury-related indicators based on neural network in the diagnosis of neonatal hypoxic-ischemic encephalopathy
  190. Analysis of early diagnosis methods for asymmetric dementia in brain MR images based on genetic medical technology
  191. Early diagnosis for the onset of peri-implantitis based on artificial neural network
  192. Clinical significance of the detection of serum IgG4 and IgG4/IgG ratio in patients with thyroid-associated ophthalmopathy
  193. Forecast of pain degree of lumbar disc herniation based on back propagation neural network
  194. SPA-UNet: A liver tumor segmentation network based on fused multi-scale features
  195. Systematic evaluation of clinical efficacy of CYP1B1 gene polymorphism in EGFR mutant non-small cell lung cancer observed by medical image
  196. Rehabilitation effect of intelligent rehabilitation training system on hemiplegic limb spasms after stroke
  197. A novel approach for minimising anti-aliasing effects in EEG data acquisition
  198. ErbB4 promotes M2 activation of macrophages in idiopathic pulmonary fibrosis
  199. Clinical role of CYP1B1 gene polymorphism in prediction of postoperative chemotherapy efficacy in NSCLC based on individualized health model
  200. Lung nodule segmentation via semi-residual multi-resolution neural networks
  201. Evaluation of brain nerve function in ICU patients with Delirium by deep learning algorithm-based resting state MRI
  202. A data mining technique for detecting malignant mesothelioma cancer using multiple regression analysis
  203. Markov model combined with MR diffusion tensor imaging for predicting the onset of Alzheimer’s disease
  204. Effectiveness of the treatment of depression associated with cancer and neuroimaging changes in depression-related brain regions in patients treated with the mediator-deuterium acupuncture method
  205. Molecular mechanism of colorectal cancer and screening of molecular markers based on bioinformatics analysis
  206. Monitoring and evaluation of anesthesia depth status data based on neuroscience
  207. Exploring the conformational dynamics and thermodynamics of EGFR S768I and G719X + S768I mutations in non-small cell lung cancer: An in silico approaches
  208. Optimised feature selection-driven convolutional neural network using gray level co-occurrence matrix for detection of cervical cancer
  209. Incidence of different pressure patterns of spinal cerebellar ataxia and analysis of imaging and genetic diagnosis
  210. Pathogenic bacteria and treatment resistance in older cardiovascular disease patients with lung infection and risk prediction model
  211. Adoption value of support vector machine algorithm-based computed tomography imaging in the diagnosis of secondary pulmonary fungal infections in patients with malignant hematological disorders
  212. From slides to insights: Harnessing deep learning for prognostic survival prediction in human colorectal cancer histology
  213. Ecology and Environmental Science
  214. Monitoring of hourly carbon dioxide concentration under different land use types in arid ecosystem
  215. Comparing the differences of prokaryotic microbial community between pit walls and bottom from Chinese liquor revealed by 16S rRNA gene sequencing
  216. Effects of cadmium stress on fruits germination and growth of two herbage species
  217. Bamboo charcoal affects soil properties and bacterial community in tea plantations
  218. Optimization of biogas potential using kinetic models, response surface methodology, and instrumental evidence for biodegradation of tannery fleshings during anaerobic digestion
  219. Understory vegetation diversity patterns of Platycladus orientalis and Pinus elliottii communities in Central and Southern China
  220. Studies on macrofungi diversity and discovery of new species of Abortiporus from Baotianman World Biosphere Reserve
  221. Food Science
  222. Effect of berrycactus fruit (Myrtillocactus geometrizans) on glutamate, glutamine, and GABA levels in the frontal cortex of rats fed with a high-fat diet
  223. Guesstimate of thymoquinone diversity in Nigella sativa L. genotypes and elite varieties collected from Indian states using HPTLC technique
  224. Analysis of bacterial community structure of Fuzhuan tea with different processing techniques
  225. Untargeted metabolomics reveals sour jujube kernel benefiting the nutritional value and flavor of Morchella esculenta
  226. Mycobiota in Slovak wine grapes: A case study from the small Carpathians wine region
  227. Elemental analysis of Fadogia ancylantha leaves used as a nutraceutical in Mashonaland West Province, Zimbabwe
  228. Microbiological transglutaminase: Biotechnological application in the food industry
  229. Influence of solvent-free extraction of fish oil from catfish (Clarias magur) heads using a Taguchi orthogonal array design: A qualitative and quantitative approach
  230. Chromatographic analysis of the chemical composition and anticancer activities of Curcuma longa extract cultivated in Palestine
  231. The potential for the use of leghemoglobin and plant ferritin as sources of iron
  232. Investigating the association between dietary patterns and glycemic control among children and adolescents with T1DM
  233. Bioengineering and Biotechnology
  234. Biocompatibility and osteointegration capability of β-TCP manufactured by stereolithography 3D printing: In vitro study
  235. Clinical characteristics and the prognosis of diabetic foot in Tibet: A single center, retrospective study
  236. Agriculture
  237. Biofertilizer and NPSB fertilizer application effects on nodulation and productivity of common bean (Phaseolus vulgaris L.) at Sodo Zuria, Southern Ethiopia
  238. On correlation between canopy vegetation and growth indexes of maize varieties with different nitrogen efficiencies
  239. Exopolysaccharides from Pseudomonas tolaasii inhibit the growth of Pleurotus ostreatus mycelia
  240. A transcriptomic evaluation of the mechanism of programmed cell death of the replaceable bud in Chinese chestnut
  241. Melatonin enhances salt tolerance in sorghum by modulating photosynthetic performance, osmoregulation, antioxidant defense, and ion homeostasis
  242. Effects of plant density on alfalfa (Medicago sativa L.) seed yield in western Heilongjiang areas
  243. Identification of rice leaf diseases and deficiency disorders using a novel DeepBatch technique
  244. Artificial intelligence and internet of things oriented sustainable precision farming: Towards modern agriculture
  245. Animal Sciences
  246. Effect of ketogenic diet on exercise tolerance and transcriptome of gastrocnemius in mice
  247. Combined analysis of mRNA–miRNA from testis tissue in Tibetan sheep with different FecB genotypes
  248. Isolation, identification, and drug resistance of a partially isolated bacterium from the gill of Siniperca chuatsi
  249. Tracking behavioral changes of confined sows from the first mating to the third parity
  250. The sequencing of the key genes and end products in the TLR4 signaling pathway from the kidney of Rana dybowskii exposed to Aeromonas hydrophila
  251. Development of a new candidate vaccine against piglet diarrhea caused by Escherichia coli
  252. Plant Sciences
  253. Crown and diameter structure of pure Pinus massoniana Lamb. forest in Hunan province, China
  254. Genetic evaluation and germplasm identification analysis on ITS2, trnL-F, and psbA-trnH of alfalfa varieties germplasm resources
  255. Tissue culture and rapid propagation technology for Gentiana rhodantha
  256. Effects of cadmium on the synthesis of active ingredients in Salvia miltiorrhiza
  257. Cloning and expression analysis of VrNAC13 gene in mung bean
  258. Chlorate-induced molecular floral transition revealed by transcriptomes
  259. Effects of warming and drought on growth and development of soybean in Hailun region
  260. Effects of different light conditions on transient expression and biomass in Nicotiana benthamiana leaves
  261. Comparative analysis of the rhizosphere microbiome and medicinally active ingredients of Atractylodes lancea from different geographical origins
  262. Distinguish Dianthus species or varieties based on chloroplast genomes
  263. Comparative transcriptomes reveal molecular mechanisms of apple blossoms of different tolerance genotypes to chilling injury
  264. Study on fresh processing key technology and quality influence of Cut Ophiopogonis Radix based on multi-index evaluation
  265. An advanced approach for fig leaf disease detection and classification: Leveraging image processing and enhanced support vector machine methodology
  266. Erratum
  267. Erratum to “Protein Z modulates the metastasis of lung adenocarcinoma cells”
  268. Erratum to “BRCA1 subcellular localization regulated by PI3K signaling pathway in triple-negative breast cancer MDA-MB-231 cells and hormone-sensitive T47D cells”
  269. Retraction
  270. Retraction to “Protocatechuic acid attenuates cerebral aneurysm formation and progression by inhibiting TNF-alpha/Nrf-2/NF-kB-mediated inflammatory mechanisms in experimental rats”
https://doi.org/10.1515/biol-2022-0691
Keywords for this article
peri-implantitis; early diagnosis; machine learning; artificial neural network
Creative Commons
BY 4.0

Articles in the same Issue

  1. Biomedical Sciences
  2. Systemic investigation of inetetamab in combination with small molecules to treat HER2-overexpressing breast and gastric cancers
  3. Immunosuppressive treatment for idiopathic membranous nephropathy: An updated network meta-analysis
  4. Identifying two pathogenic variants in a patient with pigmented paravenous retinochoroidal atrophy
  5. Effects of phytoestrogens combined with cold stress on sperm parameters and testicular proteomics in rats
  6. A case of pulmonary embolism with bad warfarin anticoagulant effects caused by E. coli infection
  7. Neutrophilia with subclinical Cushing’s disease: A case report and literature review
  8. Isoimperatorin alleviates lipopolysaccharide-induced periodontitis by downregulating ERK1/2 and NF-κB pathways
  9. Immunoregulation of synovial macrophages for the treatment of osteoarthritis
  10. Novel CPLANE1 c.8948dupT (p.P2984Tfs*7) variant in a child patient with Joubert syndrome
  11. Antiphospholipid antibodies and the risk of thrombosis in myeloproliferative neoplasms
  12. Immunological responses of septic rats to combination therapy with thymosin α1 and vitamin C
  13. High glucose and high lipid induced mitochondrial dysfunction in JEG-3 cells through oxidative stress
  14. Pharmacological inhibition of the ubiquitin-specific protease 8 effectively suppresses glioblastoma cell growth
  15. Levocarnitine regulates the growth of angiotensin II-induced myocardial fibrosis cells via TIMP-1
  16. Age-related changes in peripheral T-cell subpopulations in elderly individuals: An observational study
  17. Single-cell transcription analysis reveals the tumor origin and heterogeneity of human bilateral renal clear cell carcinoma
  18. Identification of iron metabolism-related genes as diagnostic signatures in sepsis by blood transcriptomic analysis
  19. Long noncoding RNA ACART knockdown decreases 3T3-L1 preadipocyte proliferation and differentiation
  20. Surgery, adjuvant immunotherapy plus chemotherapy and radiotherapy for primary malignant melanoma of the parotid gland (PGMM): A case report
  21. Dosimetry comparison with helical tomotherapy, volumetric modulated arc therapy, and intensity-modulated radiotherapy for grade II gliomas: A single‑institution case series
  22. Soy isoflavone reduces LPS-induced acute lung injury via increasing aquaporin 1 and aquaporin 5 in rats
  23. Refractory hypokalemia with sexual dysplasia and infertility caused by 17α-hydroxylase deficiency and triple X syndrome: A case report
  24. Meta-analysis of cancer risk among end stage renal disease undergoing maintenance dialysis
  25. 6-Phosphogluconate dehydrogenase inhibition arrests growth and induces apoptosis in gastric cancer via AMPK activation and oxidative stress
  26. Experimental study on the optimization of ANM33 release in foam cells
  27. Primary retroperitoneal angiosarcoma: A case report
  28. Metabolomic analysis-identified 2-hydroxybutyric acid might be a key metabolite of severe preeclampsia
  29. Malignant pleural effusion diagnosis and therapy
  30. Effect of spaceflight on the phenotype and proteome of Escherichia coli
  31. Comparison of immunotherapy combined with stereotactic radiotherapy and targeted therapy for patients with brain metastases: A systemic review and meta-analysis
  32. Activation of hypermethylated P2RY1 mitigates gastric cancer by promoting apoptosis and inhibiting proliferation
  33. Association between the VEGFR-2 -604T/C polymorphism (rs2071559) and type 2 diabetic retinopathy
  34. The role of IL-31 and IL-34 in the diagnosis and treatment of chronic periodontitis
  35. Triple-negative mouse breast cancer initiating cells show high expression of beta1 integrin and increased malignant features
  36. mNGS facilitates the accurate diagnosis and antibiotic treatment of suspicious critical CNS infection in real practice: A retrospective study
  37. The apatinib and pemetrexed combination has antitumor and antiangiogenic effects against NSCLC
  38. Radiotherapy for primary thyroid adenoid cystic carcinoma
  39. Design and functional preliminary investigation of recombinant antigen EgG1Y162–EgG1Y162 against Echinococcus granulosus
  40. Effects of losartan in patients with NAFLD: A meta-analysis of randomized controlled trial
  41. Bibliometric analysis of METTL3: Current perspectives, highlights, and trending topics
  42. Performance comparison of three scaling algorithms in NMR-based metabolomics analysis
  43. PI3K/AKT/mTOR pathway and its related molecules participate in PROK1 silence-induced anti-tumor effects on pancreatic cancer
  44. The altered expression of cytoskeletal and synaptic remodeling proteins during epilepsy
  45. Effects of pegylated recombinant human granulocyte colony-stimulating factor on lymphocytes and white blood cells of patients with malignant tumor
  46. Prostatitis as initial manifestation of Chlamydia psittaci pneumonia diagnosed by metagenome next-generation sequencing: A case report
  47. NUDT21 relieves sevoflurane-induced neurological damage in rats by down-regulating LIMK2
  48. Association of interleukin-10 rs1800896, rs1800872, and interleukin-6 rs1800795 polymorphisms with squamous cell carcinoma risk: A meta-analysis
  49. Exosomal HBV-DNA for diagnosis and treatment monitoring of chronic hepatitis B
  50. Shear stress leads to the dysfunction of endothelial cells through the Cav-1-mediated KLF2/eNOS/ERK signaling pathway under physiological conditions
  51. Interaction between the PI3K/AKT pathway and mitochondrial autophagy in macrophages and the leukocyte count in rats with LPS-induced pulmonary infection
  52. Meta-analysis of the rs231775 locus polymorphism in the CTLA-4 gene and the susceptibility to Graves’ disease in children
  53. Cloning, subcellular localization and expression of phosphate transporter gene HvPT6 of hulless barley
  54. Coptisine mitigates diabetic nephropathy via repressing the NRLP3 inflammasome
  55. Significant elevated CXCL14 and decreased IL-39 levels in patients with tuberculosis
  56. Whole-exome sequencing applications in prenatal diagnosis of fetal bowel dilatation
  57. Gemella morbillorum infective endocarditis: A case report and literature review
  58. An unusual ectopic thymoma clonal evolution analysis: A case report
  59. Severe cumulative skin toxicity during toripalimab combined with vemurafenib following toripalimab alone
  60. Detection of V. vulnificus septic shock with ARDS using mNGS
  61. Novel rare genetic variants of familial and sporadic pulmonary atresia identified by whole-exome sequencing
  62. The influence and mechanistic action of sperm DNA fragmentation index on the outcomes of assisted reproduction technology
  63. Novel compound heterozygous mutations in TELO2 in an infant with You-Hoover-Fong syndrome: A case report and literature review
  64. ctDNA as a prognostic biomarker in resectable CLM: Systematic review and meta-analysis
  65. Diagnosis of primary amoebic meningoencephalitis by metagenomic next-generation sequencing: A case report
  66. Phylogenetic analysis of promoter regions of human Dolichol kinase (DOLK) and orthologous genes using bioinformatics tools
  67. Collagen changes in rabbit conjunctiva after conjunctival crosslinking
  68. Effects of NM23 transfection of human gastric carcinoma cells in mice
  69. Oral nifedipine and phytosterol, intravenous nicardipine, and oral nifedipine only: Three-arm, retrospective, cohort study for management of severe preeclampsia
  70. Case report of hepatic retiform hemangioendothelioma: A rare tumor treated with ultrasound-guided microwave ablation
  71. Curcumin induces apoptosis in human hepatocellular carcinoma cells by decreasing the expression of STAT3/VEGF/HIF-1α signaling
  72. Rare presentation of double-clonal Waldenström macroglobulinemia with pulmonary embolism: A case report
  73. Giant duplication of the transverse colon in an adult: A case report and literature review
  74. Ectopic thyroid tissue in the breast: A case report
  75. SDR16C5 promotes proliferation and migration and inhibits apoptosis in pancreatic cancer
  76. Vaginal metastasis from breast cancer: A case report
  77. Screening of the best time window for MSC transplantation to treat acute myocardial infarction with SDF-1α antibody-loaded targeted ultrasonic microbubbles: An in vivo study in miniswine
  78. Inhibition of TAZ impairs the migration ability of melanoma cells
  79. Molecular complexity analysis of the diagnosis of Gitelman syndrome in China
  80. Effects of maternal calcium and protein intake on the development and bone metabolism of offspring mice
  81. Identification of winter wheat pests and diseases based on improved convolutional neural network
  82. Ultra-multiplex PCR technique to guide treatment of Aspergillus-infected aortic valve prostheses
  83. Virtual high-throughput screening: Potential inhibitors targeting aminopeptidase N (CD13) and PIKfyve for SARS-CoV-2
  84. Immune checkpoint inhibitors in cancer patients with COVID-19
  85. Utility of methylene blue mixed with autologous blood in preoperative localization of pulmonary nodules and masses
  86. Integrated analysis of the microbiome and transcriptome in stomach adenocarcinoma
  87. Berberine suppressed sarcopenia insulin resistance through SIRT1-mediated mitophagy
  88. DUSP2 inhibits the progression of lupus nephritis in mice by regulating the STAT3 pathway
  89. Lung abscess by Fusobacterium nucleatum and Streptococcus spp. co-infection by mNGS: A case series
  90. Genetic alterations of KRAS and TP53 in intrahepatic cholangiocarcinoma associated with poor prognosis
  91. Granulomatous polyangiitis involving the fourth ventricle: Report of a rare case and a literature review
  92. Studying infant mortality: A demographic analysis based on data mining models
  93. Metaplastic breast carcinoma with osseous differentiation: A report of a rare case and literature review
  94. Protein Z modulates the metastasis of lung adenocarcinoma cells
  95. Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro
  96. TAK-242, a toll-like receptor 4 antagonist, against brain injury by alleviates autophagy and inflammation in rats
  97. Primary mediastinum Ewing’s sarcoma with pleural effusion: A case report and literature review
  98. Association of ADRB2 gene polymorphisms and intestinal microbiota in Chinese Han adolescents
  99. Tanshinone IIA alleviates chondrocyte apoptosis and extracellular matrix degeneration by inhibiting ferroptosis
  100. Study on the cytokines related to SARS-Cov-2 in testicular cells and the interaction network between cells based on scRNA-seq data
  101. Effect of periostin on bone metabolic and autophagy factors during tooth eruption in mice
  102. HP1 induces ferroptosis of renal tubular epithelial cells through NRF2 pathway in diabetic nephropathy
  103. Intravaginal estrogen management in postmenopausal patients with vaginal squamous intraepithelial lesions along with CO2 laser ablation: A retrospective study
  104. Hepatocellular carcinoma cell differentiation trajectory predicts immunotherapy, potential therapeutic drugs, and prognosis of patients
  105. Effects of physical exercise on biomarkers of oxidative stress in healthy subjects: A meta-analysis of randomized controlled trials
  106. Identification of lysosome-related genes in connection with prognosis and immune cell infiltration for drug candidates in head and neck cancer
  107. Development of an instrument-free and low-cost ELISA dot-blot test to detect antibodies against SARS-CoV-2
  108. Research progress on gas signal molecular therapy for Parkinson’s disease
  109. Adiponectin inhibits TGF-β1-induced skin fibroblast proliferation and phenotype transformation via the p38 MAPK signaling pathway
  110. The G protein-coupled receptor-related gene signatures for predicting prognosis and immunotherapy response in bladder urothelial carcinoma
  111. α-Fetoprotein contributes to the malignant biological properties of AFP-producing gastric cancer
  112. CXCL12/CXCR4/CXCR7 axis in placenta tissues of patients with placenta previa
  113. Association between thyroid stimulating hormone levels and papillary thyroid cancer risk: A meta-analysis
  114. Significance of sTREM-1 and sST2 combined diagnosis for sepsis detection and prognosis prediction
  115. Diagnostic value of serum neuroactive substances in the acute exacerbation of chronic obstructive pulmonary disease complicated with depression
  116. Research progress of AMP-activated protein kinase and cardiac aging
  117. TRIM29 knockdown prevented the colon cancer progression through decreasing the ubiquitination levels of KRT5
  118. Cross-talk between gut microbiota and liver steatosis: Complications and therapeutic target
  119. Metastasis from small cell lung cancer to ovary: A case report
  120. The early diagnosis and pathogenic mechanisms of sepsis-related acute kidney injury
  121. The effect of NK cell therapy on sepsis secondary to lung cancer: A case report
  122. Erianin alleviates collagen-induced arthritis in mice by inhibiting Th17 cell differentiation
  123. Loss of ACOX1 in clear cell renal cell carcinoma and its correlation with clinical features
  124. Signalling pathways in the osteogenic differentiation of periodontal ligament stem cells
  125. Crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failure
  126. Clinicopathological features and differential diagnosis of gastric pleomorphic giant cell carcinoma
  127. Traumatic brain injury and rTMS-ERPs: Case report and literature review
  128. Extracellular fibrin promotes non-small cell lung cancer progression through integrin β1/PTEN/AKT signaling
  129. Knockdown of DLK4 inhibits non-small cell lung cancer tumor growth by downregulating CKS2
  130. The co-expression pattern of VEGFR-2 with indicators related to proliferation, apoptosis, and differentiation of anagen hair follicles
  131. Inflammation-related signaling pathways in tendinopathy
  132. CD4+ T cell count in HIV/TB co-infection and co-occurrence with HL: Case report and literature review
  133. Clinical analysis of severe Chlamydia psittaci pneumonia: Case series study
  134. Bioinformatics analysis to identify potential biomarkers for the pulmonary artery hypertension associated with the basement membrane
  135. Influence of MTHFR polymorphism, alone or in combination with smoking and alcohol consumption, on cancer susceptibility
  136. Catharanthus roseus (L.) G. Don counteracts the ampicillin resistance in multiple antibiotic-resistant Staphylococcus aureus by downregulation of PBP2a synthesis
  137. Combination of a bronchogenic cyst in the thoracic spinal canal with chronic myelocytic leukemia
  138. Bacterial lipoprotein plays an important role in the macrophage autophagy and apoptosis induced by Salmonella typhimurium and Staphylococcus aureus
  139. TCL1A+ B cells predict prognosis in triple-negative breast cancer through integrative analysis of single-cell and bulk transcriptomic data
  140. Ezrin promotes esophageal squamous cell carcinoma progression via the Hippo signaling pathway
  141. Ferroptosis: A potential target of macrophages in plaque vulnerability
  142. Predicting pediatric Crohn's disease based on six mRNA-constructed risk signature using comprehensive bioinformatic approaches
  143. Applications of genetic code expansion and photosensitive UAAs in studying membrane proteins
  144. HK2 contributes to the proliferation, migration, and invasion of diffuse large B-cell lymphoma cells by enhancing the ERK1/2 signaling pathway
  145. IL-17 in osteoarthritis: A narrative review
  146. Circadian cycle and neuroinflammation
  147. Probiotic management and inflammatory factors as a novel treatment in cirrhosis: A systematic review and meta-analysis
  148. Hemorrhagic meningioma with pulmonary metastasis: Case report and literature review
  149. SPOP regulates the expression profiles and alternative splicing events in human hepatocytes
  150. Knockdown of SETD5 inhibited glycolysis and tumor growth in gastric cancer cells by down-regulating Akt signaling pathway
  151. PTX3 promotes IVIG resistance-induced endothelial injury in Kawasaki disease by regulating the NF-κB pathway
  152. Pancreatic ectopic thyroid tissue: A case report and analysis of literature
  153. The prognostic impact of body mass index on female breast cancer patients in underdeveloped regions of northern China differs by menopause status and tumor molecular subtype
  154. Report on a case of liver-originating malignant melanoma of unknown primary
  155. Case report: Herbal treatment of neutropenic enterocolitis after chemotherapy for breast cancer
  156. The fibroblast growth factor–Klotho axis at molecular level
  157. Characterization of amiodarone action on currents in hERG-T618 gain-of-function mutations
  158. A case report of diagnosis and dynamic monitoring of Listeria monocytogenes meningitis with NGS
  159. Effect of autologous platelet-rich plasma on new bone formation and viability of a Marburg bone graft
  160. Small breast epithelial mucin as a useful prognostic marker for breast cancer patients
  161. Continuous non-adherent culture promotes transdifferentiation of human adipose-derived stem cells into retinal lineage
  162. Nrf3 alleviates oxidative stress and promotes the survival of colon cancer cells by activating AKT/BCL-2 signal pathway
  163. Favorable response to surufatinib in a patient with necrolytic migratory erythema: A case report
  164. Case report of atypical undernutrition of hypoproteinemia type
  165. Down-regulation of COL1A1 inhibits tumor-associated fibroblast activation and mediates matrix remodeling in the tumor microenvironment of breast cancer
  166. Sarcoma protein kinase inhibition alleviates liver fibrosis by promoting hepatic stellate cells ferroptosis
  167. Research progress of serum eosinophil in chronic obstructive pulmonary disease and asthma
  168. Clinicopathological characteristics of co-existing or mixed colorectal cancer and neuroendocrine tumor: Report of five cases
  169. Role of menopausal hormone therapy in the prevention of postmenopausal osteoporosis
  170. Precisional detection of lymph node metastasis using tFCM in colorectal cancer
  171. Advances in diagnosis and treatment of perimenopausal syndrome
  172. A study of forensic genetics: ITO index distribution and kinship judgment between two individuals
  173. Acute lupus pneumonitis resembling miliary tuberculosis: A case-based review
  174. Plasma levels of CD36 and glutathione as biomarkers for ruptured intracranial aneurysm
  175. Fractalkine modulates pulmonary angiogenesis and tube formation by modulating CX3CR1 and growth factors in PVECs
  176. Novel risk prediction models for deep vein thrombosis after thoracotomy and thoracoscopic lung cancer resections, involving coagulation and immune function
  177. Exploring the diagnostic markers of essential tremor: A study based on machine learning algorithms
  178. Evaluation of effects of small-incision approach treatment on proximal tibia fracture by deep learning algorithm-based magnetic resonance imaging
  179. An online diagnosis method for cancer lesions based on intelligent imaging analysis
  180. Medical imaging in rheumatoid arthritis: A review on deep learning approach
  181. Predictive analytics in smart healthcare for child mortality prediction using a machine learning approach
  182. Utility of neutrophil–lymphocyte ratio and platelet–lymphocyte ratio in predicting acute-on-chronic liver failure survival
  183. A biomedical decision support system for meta-analysis of bilateral upper-limb training in stroke patients with hemiplegia
  184. TNF-α and IL-8 levels are positively correlated with hypobaric hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats
  185. Stochastic gradient descent optimisation for convolutional neural network for medical image segmentation
  186. Comparison of the prognostic value of four different critical illness scores in patients with sepsis-induced coagulopathy
  187. Application and teaching of computer molecular simulation embedded technology and artificial intelligence in drug research and development
  188. Hepatobiliary surgery based on intelligent image segmentation technology
  189. Value of brain injury-related indicators based on neural network in the diagnosis of neonatal hypoxic-ischemic encephalopathy
  190. Analysis of early diagnosis methods for asymmetric dementia in brain MR images based on genetic medical technology
  191. Early diagnosis for the onset of peri-implantitis based on artificial neural network
  192. Clinical significance of the detection of serum IgG4 and IgG4/IgG ratio in patients with thyroid-associated ophthalmopathy
  193. Forecast of pain degree of lumbar disc herniation based on back propagation neural network
  194. SPA-UNet: A liver tumor segmentation network based on fused multi-scale features
  195. Systematic evaluation of clinical efficacy of CYP1B1 gene polymorphism in EGFR mutant non-small cell lung cancer observed by medical image
  196. Rehabilitation effect of intelligent rehabilitation training system on hemiplegic limb spasms after stroke
  197. A novel approach for minimising anti-aliasing effects in EEG data acquisition
  198. ErbB4 promotes M2 activation of macrophages in idiopathic pulmonary fibrosis
  199. Clinical role of CYP1B1 gene polymorphism in prediction of postoperative chemotherapy efficacy in NSCLC based on individualized health model
  200. Lung nodule segmentation via semi-residual multi-resolution neural networks
  201. Evaluation of brain nerve function in ICU patients with Delirium by deep learning algorithm-based resting state MRI
  202. A data mining technique for detecting malignant mesothelioma cancer using multiple regression analysis
  203. Markov model combined with MR diffusion tensor imaging for predicting the onset of Alzheimer’s disease
  204. Effectiveness of the treatment of depression associated with cancer and neuroimaging changes in depression-related brain regions in patients treated with the mediator-deuterium acupuncture method
  205. Molecular mechanism of colorectal cancer and screening of molecular markers based on bioinformatics analysis
  206. Monitoring and evaluation of anesthesia depth status data based on neuroscience
  207. Exploring the conformational dynamics and thermodynamics of EGFR S768I and G719X + S768I mutations in non-small cell lung cancer: An in silico approaches
  208. Optimised feature selection-driven convolutional neural network using gray level co-occurrence matrix for detection of cervical cancer
  209. Incidence of different pressure patterns of spinal cerebellar ataxia and analysis of imaging and genetic diagnosis
  210. Pathogenic bacteria and treatment resistance in older cardiovascular disease patients with lung infection and risk prediction model
  211. Adoption value of support vector machine algorithm-based computed tomography imaging in the diagnosis of secondary pulmonary fungal infections in patients with malignant hematological disorders
  212. From slides to insights: Harnessing deep learning for prognostic survival prediction in human colorectal cancer histology
  213. Ecology and Environmental Science
  214. Monitoring of hourly carbon dioxide concentration under different land use types in arid ecosystem
  215. Comparing the differences of prokaryotic microbial community between pit walls and bottom from Chinese liquor revealed by 16S rRNA gene sequencing
  216. Effects of cadmium stress on fruits germination and growth of two herbage species
  217. Bamboo charcoal affects soil properties and bacterial community in tea plantations
  218. Optimization of biogas potential using kinetic models, response surface methodology, and instrumental evidence for biodegradation of tannery fleshings during anaerobic digestion
  219. Understory vegetation diversity patterns of Platycladus orientalis and Pinus elliottii communities in Central and Southern China
  220. Studies on macrofungi diversity and discovery of new species of Abortiporus from Baotianman World Biosphere Reserve
  221. Food Science
  222. Effect of berrycactus fruit (Myrtillocactus geometrizans) on glutamate, glutamine, and GABA levels in the frontal cortex of rats fed with a high-fat diet
  223. Guesstimate of thymoquinone diversity in Nigella sativa L. genotypes and elite varieties collected from Indian states using HPTLC technique
  224. Analysis of bacterial community structure of Fuzhuan tea with different processing techniques
  225. Untargeted metabolomics reveals sour jujube kernel benefiting the nutritional value and flavor of Morchella esculenta
  226. Mycobiota in Slovak wine grapes: A case study from the small Carpathians wine region
  227. Elemental analysis of Fadogia ancylantha leaves used as a nutraceutical in Mashonaland West Province, Zimbabwe
  228. Microbiological transglutaminase: Biotechnological application in the food industry
  229. Influence of solvent-free extraction of fish oil from catfish (Clarias magur) heads using a Taguchi orthogonal array design: A qualitative and quantitative approach
  230. Chromatographic analysis of the chemical composition and anticancer activities of Curcuma longa extract cultivated in Palestine
  231. The potential for the use of leghemoglobin and plant ferritin as sources of iron
  232. Investigating the association between dietary patterns and glycemic control among children and adolescents with T1DM
  233. Bioengineering and Biotechnology
  234. Biocompatibility and osteointegration capability of β-TCP manufactured by stereolithography 3D printing: In vitro study
  235. Clinical characteristics and the prognosis of diabetic foot in Tibet: A single center, retrospective study
  236. Agriculture
  237. Biofertilizer and NPSB fertilizer application effects on nodulation and productivity of common bean (Phaseolus vulgaris L.) at Sodo Zuria, Southern Ethiopia
  238. On correlation between canopy vegetation and growth indexes of maize varieties with different nitrogen efficiencies
  239. Exopolysaccharides from Pseudomonas tolaasii inhibit the growth of Pleurotus ostreatus mycelia
  240. A transcriptomic evaluation of the mechanism of programmed cell death of the replaceable bud in Chinese chestnut
  241. Melatonin enhances salt tolerance in sorghum by modulating photosynthetic performance, osmoregulation, antioxidant defense, and ion homeostasis
  242. Effects of plant density on alfalfa (Medicago sativa L.) seed yield in western Heilongjiang areas
  243. Identification of rice leaf diseases and deficiency disorders using a novel DeepBatch technique
  244. Artificial intelligence and internet of things oriented sustainable precision farming: Towards modern agriculture
  245. Animal Sciences
  246. Effect of ketogenic diet on exercise tolerance and transcriptome of gastrocnemius in mice
  247. Combined analysis of mRNA–miRNA from testis tissue in Tibetan sheep with different FecB genotypes
  248. Isolation, identification, and drug resistance of a partially isolated bacterium from the gill of Siniperca chuatsi
  249. Tracking behavioral changes of confined sows from the first mating to the third parity
  250. The sequencing of the key genes and end products in the TLR4 signaling pathway from the kidney of Rana dybowskii exposed to Aeromonas hydrophila
  251. Development of a new candidate vaccine against piglet diarrhea caused by Escherichia coli
  252. Plant Sciences
  253. Crown and diameter structure of pure Pinus massoniana Lamb. forest in Hunan province, China
  254. Genetic evaluation and germplasm identification analysis on ITS2, trnL-F, and psbA-trnH of alfalfa varieties germplasm resources
  255. Tissue culture and rapid propagation technology for Gentiana rhodantha
  256. Effects of cadmium on the synthesis of active ingredients in Salvia miltiorrhiza
  257. Cloning and expression analysis of VrNAC13 gene in mung bean
  258. Chlorate-induced molecular floral transition revealed by transcriptomes
  259. Effects of warming and drought on growth and development of soybean in Hailun region
  260. Effects of different light conditions on transient expression and biomass in Nicotiana benthamiana leaves
  261. Comparative analysis of the rhizosphere microbiome and medicinally active ingredients of Atractylodes lancea from different geographical origins
  262. Distinguish Dianthus species or varieties based on chloroplast genomes
  263. Comparative transcriptomes reveal molecular mechanisms of apple blossoms of different tolerance genotypes to chilling injury
  264. Study on fresh processing key technology and quality influence of Cut Ophiopogonis Radix based on multi-index evaluation
  265. An advanced approach for fig leaf disease detection and classification: Leveraging image processing and enhanced support vector machine methodology
  266. Erratum
  267. Erratum to “Protein Z modulates the metastasis of lung adenocarcinoma cells”
  268. Erratum to “BRCA1 subcellular localization regulated by PI3K signaling pathway in triple-negative breast cancer MDA-MB-231 cells and hormone-sensitive T47D cells”
  269. Retraction
  270. Retraction to “Protocatechuic acid attenuates cerebral aneurysm formation and progression by inhibiting TNF-alpha/Nrf-2/NF-kB-mediated inflammatory mechanisms in experimental rats”
Sign up now to receive a 20% welcome discount
Institutional Access
How does access work?
Have an idea on how to improve our website?
Please write us.
© 2025 De Gruyter Brill
Downloaded on 7.9.2025 from https://www.degruyterbrill.com/document/doi/10.1515/biol-2022-0691/html
Scroll to top button