Startseite Medizin Comparison of open and percutaneous A1 pulley release in pediatric trigger thumb: a retrospective cohort study
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Comparison of open and percutaneous A1 pulley release in pediatric trigger thumb: a retrospective cohort study

  • Soner Kocak ORCID logo EMAIL logo und Sabri Kerem Diril ORCID logo
Veröffentlicht/Copyright: 19. Dezember 2025

Abstract

Objectives

Pediatric trigger thumb (PTT) is characterized by flexion deformity and interphalangeal joint locking caused by A1 pulley constriction. Open A1 pulley release is the standard surgical method, whereas percutaneous release under local anesthesia offers a minimally invasive outpatient alternative. This study compared the outcomes of these two techniques.

Methods

A retrospective cohort of children aged 2–10 years undergoing A1 pulley release between 2012 and 2024 was analyzed. Patients were assigned to open release under general anesthesia or percutaneous release under local anesthesia. Demographics, operative details, complications, and outcomes were compared using appropriate statistical tests, with significance set at p<0.05.

Results

Ninety-nine patients (107 thumbs) were included: 53 (58 thumbs) in the open group and 46 (49 thumbs) in the percutaneous group. Mean age at surgery was similar (4.33 ± 1.53 vs. 4.29 ± 1.70 years; p=0.781). Satisfactory results were achieved in 100 % of open and 85.7 % of percutaneous cases (p=0.003). Recurrence was 3.4 % and 8.2 %, respectively (p=0.409). No neurovascular or tendon injuries occurred; superficial infections were minor and limited to the open group.

Conclusions

Both techniques are effective and safe. Open release remains the gold standard, while percutaneous release is a practical minimally invasive option in selected patients.

Level of evidence

III, retrospective comparative study. 

Introduction

Pediatric trigger thumb (PTT) is a common disorder in children, characterized by flexion deformity and locking of the interphalangeal joint, typically caused by thickening or constriction of the A1 pulley, which impairs flexor pollicis longus tendon gliding and creates a dimensional mismatch between the tendon and pulley [1], 2]. The reported prevalence of PTT is up to 3.3 per 1,000 live births, and while its exact pathogenesis remains uncertain, it is generally attributed to a multifactorial interaction of congenital predisposition and acquired influences [3], [4], [5]. Management options include observation, splinting, stretching exercises, and surgical release, with surgery being indicated in cases refractory to conservative treatment, where it has consistently demonstrated safety and efficacy [6], [7], [8]. In clinical practice, conservative approaches are usually preferred in children younger than two years, whereas surgical A1 pulley release is commonly recommended for those older than two years [9], [10], [11].

A1 pulley release can be performed using either open or percutaneous techniques. Open release has been considered the standard approach, as it allows direct visualization of the pulley and adjacent neurovascular structures, thereby minimizing the risk of incomplete release and neurovascular injury. However, the need for hospitalization, operating room use, a surgical incision, and postoperative wound care are regarded as disadvantages. In contrast, percutaneous release does not require hospitalization or a surgical incision, and it can be performed under local anesthesia in an outpatient setting without the need for an operating room. Its minimally invasive nature and shorter operative time make it relatively simpler and faster, with little to no scar formation at the surgical site. Nonetheless, despite these theoretical advantages, concerns remain regarding incomplete release, iatrogenic injury, and recurrence [12], [13], [14].

Although both techniques have been well described in the literature, studies comparing their relative efficacy and safety have produced inconsistent findings, and no clear consensus has been established regarding the optimal approach. This gap underscores the need for further comparative research. Therefore, the aim of the present study is to evaluate and compare open and percutaneous A1 pulley release in pediatric trigger thumb, with particular emphasis on recurrence, complications, and both clinical and functional outcomes.

Methods

This retrospective comparative study included pediatric patients who underwent surgery for trigger thumb at our institution between 2012 and 2024.

Patient data were extracted from hospital records. When medical documentation was incomplete or required clarification, structured telephone interviews were conducted with caregivers during routine outpatient visits to obtain complementary information. These interviews focused on verifying treatment adherence, follow-up compliance, and developmental milestones. Only patients with complete medical documentation who met the predefined inclusion criteria were enrolled in the study. Demographic variables included age, sex, laterality, and socioeconomic status (SES). The study population represented a broad range of socioeconomic backgrounds.

The study included patients aged 2–10 years who were diagnosed with pediatric trigger thumb presenting with flexion contracture and/or interphalangeal joint locking, whose deformity persisted beyond the age of 2 despite failed conservative treatment, and who underwent primary A1 pulley release using either an open or percutaneous technique. Patients were excluded if they had a history of previous thumb surgery, major trauma or fracture involving the affected hand, associated congenital hand anomalies, neuromuscular disorders, or syndromic conditions. Additional exclusion criteria were loss to follow-up, insufficient postoperative data, or incomplete medical records that could not be verified through caregiver interviews.

The primary clinical findings in affected thumbs were fixed flexion contracture, the presence of a Notta’s nodule, and pain. Additional findings included loss of active extension and triggering or snapping phenomena. Medical records of patients diagnosed with trigger thumb were reviewed for age at presentation, age at onset of triggering, age at surgery, presence of a palpable nodule, and fixed flexion contracture.

Operative notes were examined for anesthesia type, surgical technique, timing of the procedure, flexor tendon condition, and details of the pulley release. All patients were followed for a minimum of 12 months. Outcomes and recurrence were evaluated both by the treating physicians during scheduled outpatient visits and by parents.

Postoperative assessments included evaluation of triggering, range of motion, persistence of flexion contracture, pain, scar formation, flexor tendon integrity, and complications such as hematoma, swelling, infection, sensory deficit, or neurovascular injury. Digital nerve function was tested on the ulnar and radial aspects of the thumb by assessing light touch and pinprick sensations and comparing them with adjacent digits. Additionally, the parental assessment during follow-up interviews provided a subjective measure of functional outcome related to daily activities.

Satisfactory postoperative outcome was defined as full range of motion with complete extension and absence of triggering. Residual triggering, incomplete extension, or reduced motion was classified as unsatisfactory. In bilateral cases, each thumb was analyzed as an independent unit. Recurrence was defined as reappearance of flexion contracture and/or interphalangeal joint locking during follow-up.

This study was conducted using a retrospective cohort design, and patients were divided into two groups. One surgeon performed open A1 pulley release under general anesthesia in the operating room, whereas the other surgeon carried out percutaneous release under local anesthesia in the outpatient clinic.

Surgical techniques

Open release

Open A1 pulley release was performed under short-duration general anesthesia with tourniquet control. A transverse incision was made along the palmar crease overlying the first metacarpophalangeal joint. Dissection was carefully carried out to expose the flexor sheath while preserving the digital neurovascular bundles. The A1 pulley was identified under direct visualization and fully released. Flexor tendons and neurovascular structures were meticulously protected throughout the procedure. Intraoperatively, residual triggering was checked by passively flexing and fully extending the interphalangeal joint (Figure 1). The skin was closed with absorbable sutures. To prevent hematoma and swelling, gentle compression and a light dressing were applied for 10 min postoperatively. Patients were discharged the following day.

Figure 1: 
Open A1 pulley release. (a) Preoperative view showing fixed flexion contracture of the thumb. (b) Intraoperative marking of Notta’s nodule and the flexor tendon pathway. (c) Exposure of the A1 pulley achieved through appropriate retraction. (d) Passive thumb extension used to confirm complete tendon release following A1 pulley division. (e) Passive flexion of the interphalangeal joint to verify smooth tendon gliding after release.
Figure 1:

Open A1 pulley release. (a) Preoperative view showing fixed flexion contracture of the thumb. (b) Intraoperative marking of Notta’s nodule and the flexor tendon pathway. (c) Exposure of the A1 pulley achieved through appropriate retraction. (d) Passive thumb extension used to confirm complete tendon release following A1 pulley division. (e) Passive flexion of the interphalangeal joint to verify smooth tendon gliding after release.

Percutaneous release

All percutaneous releases were performed by the same surgeon under local anesthesia, without the use of a tourniquet. A digital nerve block was administered with 1 mL of 2 % lidocaine. With the thumb placed in abduction and extension, a 21-gauge hypodermic needle was introduced through the skin at the level of the A1 pulley, just distal to the nodule on the palmar surface. The needle was positioned parallel to the flexor tendon and advanced 3–5 mm to penetrate it. Proper intratendinous positioning was confirmed by passive thumb motion. The needle was then slightly withdrawn and swept proximally to distally along the tendon axis while maintaining passive extension, thereby dividing the A1 pulley in a controlled manner. To minimize the risk of nerve injury, the entry point was selected at the metacarpophalangeal crease and kept close to the midline. Complete release was confirmed intraoperatively by restoration of full interphalangeal flexion and extension and disappearance of locking (Figure 2). All patients tolerated the percutaneous procedure well; no sedation was required, parents were allowed to remain with the child to reduce anxiety, and no adverse events related to intolerance or inadequate anesthesia occurred. No sutures were required. A light compressive dressing was applied for 10 min postoperatively, and all patients were discharged on the same day.

Figure 2: 
Percutaneous A1 pulley release. (a) Preoperative presentation of a fixed flexion contracture in the thumb. (b) Intraoperative identification of Notta’s nodule and the flexor tendon pathway, followed by marking and selection of the needle entry site. (c) Percutaneous division of the A1 pulley performed by inserting the needle just distal to the nodule and applying longitudinal sweeping movements. (d) Intraoperative assessment of tendon release through passive extension of the thumb.
Figure 2:

Percutaneous A1 pulley release. (a) Preoperative presentation of a fixed flexion contracture in the thumb. (b) Intraoperative identification of Notta’s nodule and the flexor tendon pathway, followed by marking and selection of the needle entry site. (c) Percutaneous division of the A1 pulley performed by inserting the needle just distal to the nodule and applying longitudinal sweeping movements. (d) Intraoperative assessment of tendon release through passive extension of the thumb.

All patients received standard postoperative care. Early postoperative assessments focused on bleeding, swelling, and hematoma formation. A light compressive dressing was applied with the thumb in extension for one week, and nonsteroidal anti-inflammatory medication was prescribed as needed. Follow-up visits were scheduled at 1–2 weeks, 1 month, and at the final evaluation.

To minimize observer bias, postoperative assessments were conducted by an independent surgeon blinded to the treatment groups. Demographic variables, including age, sex, and laterality, were documented to ensure comparability between groups. Potential confounders – such as age at release, sex, and laterality – were adjusted for using post-hoc multivariate logistic regression analysis. Although randomization was not feasible due to the retrospective nature of the study, methodological rigor was preserved through comprehensive data collection and appropriate statistical adjustments to reduce bias.

The study protocol was approved by the institutional ethics committee, and informed consent was obtained from the parents or legal guardians of all participants.

Statistical analysis

All statistical analyses were conducted using SPSS Statistics version 25.0. Normality of continuous variables was assessed using the Shapiro–Wilk test. Age and follow-up duration were analyzed as continuous variables. Age demonstrated normal distribution and was analyzed using the Student’s t-test, whereas follow-up duration, which did not demonstrate normality, was analyzed using the Mann–Whitney U test. Categorical variables including sex, laterality, recurrence, and complication rates were analyzed using the Chi-square test or Fisher’s exact test when expected cell counts were <5. Group comparisons for continuous variables were performed with either the Student’s t-test or the Mann–Whitney U test, depending on distributional assumptions, whereas categorical variables were analyzed using the Chi-square or Fisher’s exact test as appropriate. Statistical significance was defined as p<0.05.

Results

A total of 99 patients (107 thumbs) were included in the study. The open release group comprised 53 patients (58 thumbs), while the percutaneous release group included 46 patients (49 thumbs). The mean follow-up period was 49 months (range, 12–68 months) for the open group and 38 months (range, 12–58 months) for the percutaneous group.

The sex distribution in the open group was 28 males (52.8 %) and 25 females (47.2 %), compared to 20 males (43.5 %) and 26 females (56.5 %) in the percutaneous group. There was no statistically significant difference between groups regarding sex distribution (p=0.467).

The mean age at the time of surgery was 4.33 ± 1.53 years (range, 2–8 years) in the open group and 4.29 ± 1.70 years (range, 2–9 years) in the percutaneous group, with no significant difference between groups (p=0.781).

Regarding laterality, 30 right (51.7 %) and 28 left (48.3 %) thumbs underwent surgery in the open group, while 24 right (49.0 %) and 25 left (51.0 %) thumbs were operated on in the percutaneous group. Side distribution was comparable, with no significant difference between groups (p=0.929) (Table 1).

Table 1:

Demographic characteristics of patients.

Open release Percutaneous release p-Value
Cases;

Unilateral

Bilateral
53 (100 %)

48 (90.6 %)

5 (9.4 %)
46 (100 %)

43 (93.5 %)

3 (6.5 %)
0.73
Sex;

Male

Female
28 (52.8 %)

25 (47.2 %)
20 (43.5 %)

26 (56.5 %)
0.467
Laterality (thumbs);

Right

Left
30 (51.7 %)

28 (48.3 %)
24 (49 %)

25 (51 %)
0.929
Age at surgery (years, mean ± SD, range) 4.33 ± 1.53 (2–8) 4.29 ± 1.70 (2–9) 0.781
Follow-up duration (month) 49 (range 12–68) 38 (range 12–58)

All thumbs in the open release group achieved satisfactory outcomes (58/58; 100 %). In the percutaneous group, 42 thumbs (85.7 %) had satisfactory results, while 7 thumbs (14.3 %) were classified as unsatisfactory. The difference in outcomes between the two groups was statistically significant (p=0.003). Recurrence occurred in 2 thumbs (3.4 %) in the open group and in 4 thumbs (8.2 %) in the percutaneous group, with no statistically significant difference between groups (p=0.409) (Table 2).

Table 2:

Surgical outcomes and recurrence.

Open release (n=58) Percutaneous release (n=49) p-Value
Outcome (thumbs);

Satisfactory

Unsatisfactory
58 (100 %)

0 (0 %)
42 (85.7 %)

7 (14.3 %)
0.003
Recurrence 2 (3.4 %) 4 (8.2 %) 0.409

Superficial postoperative infection was observed in two open-release cases, both of which resolved with oral antibiotics; no recurrences were noted in these patients. No cases of nerve injury, flexor tendon injury, sensory deficit, hyperextension deformity of the metacarpophalangeal joint, or postoperative motion restriction were encountered during follow-up. All patients maintained normal grip function in daily activities, and those with satisfactory surgical results achieved grip strength comparable to the contralateral thumb.

Patients with unsatisfactory outcomes underwent secondary open surgical release. Similarly, in both groups, cases with recurrence during follow-up were managed with revision open release.

Discussion

This retrospective comparative study evaluated the clinical and functional outcomes of percutaneous A1 pulley release performed under local anesthesia in the outpatient setting vs. open release under general anesthesia in the operating room for the treatment of pediatric trigger thumb. Both techniques were found to be effective and safe, demonstrating high success rates and low complication rates. However, notable differences emerged between the two approaches in terms of success rate, recurrence, procedural logistics, and perioperative considerations.

Previous studies have established open A1 pulley release as the standard surgical approach in most centers, reporting excellent success rates with minimal recurrence and low complication rates, which is consistent with our findings [2], 13], 15], 16]. In our cohort, open release achieved a 100 % satisfactory rate, with only two cases of superficial infection and no neurovascular or tendon injury. The recurrence rate of 3.4 % aligns with previously reported ranges [13], 17], 18]. These findings are further supported by a recent long-term study evaluating 67 pediatric trigger thumbs with a minimum follow-up of 10 years, in which 94 % of patients achieved full interphalangeal extension, the median QuickDASH score was 0, overall satisfaction was high (84 % reporting the maximum score), and no cases of residual triggering or revision surgery were observed [19].

Percutaneous release performed under local anesthesia yielded a satisfactory outcome in 85.7 % of cases without any major complications or neurovascular injuries. This finding is comparable to pediatric series that reported success rates between 92 % and 97 % for percutaneous techniques performed in outpatient settings [12], 20], 21]. However, Masquijo et al. cautioned against the routine use of percutaneous methods in children, citing incomplete pulley division and flexor tendon laceration as potential concerns [14]. In our study, although the recurrence rate in the percutaneous group (8.2 %) was slightly higher than in the open group, the difference was not statistically significant. Nevertheless, a systematic review by Sirithiantong et al. reported that percutaneous release increased the risk of recurrence 3.29-fold compared to open surgery, recommending open release as the preferred surgical option when intervention is required [22].

Clinically, both techniques are viable but serve different contexts. Open release allows direct visualization of the pulley and adjacent neurovascular structures, minimizing the risk of incomplete division and flexor tendon injury. Although recent pediatric anesthesia literature indicates that short-term general anesthesia does not significantly differ from awake regional anesthesia regarding long-term neurodevelopmental outcomes, parents often prefer to avoid general anesthesia when possible [23]. Conversely, percutaneous release offers distinct logistical advantages – it can be performed in the outpatient clinic without general anesthesia, hospitalization, or operating room requirements, while leaving minimal scarring. This makes it an attractive option for compliant patients with typical anatomy, particularly in resource-limited settings or for children in whom minimizing anesthetic exposure is desirable. Furthermore, a 2022 randomized controlled trial demonstrated that targeted local anesthetic infiltration prior to incision significantly reduced intraoperative general anesthetic requirements during pediatric trigger thumb release, supporting the feasibility and anesthetic-sparing advantages of outpatient percutaneous procedures in appropriately selected children [24].

From a healthcare systems perspective, outpatient percutaneous procedures may reduce hospital stay, surgical waiting times, and overall costs while maintaining favorable outcomes. Hand surgery literature supports the transition of minor procedures from operating rooms to outpatient clinics as a means to achieve substantial cost savings without compromising clinical efficacy [25], 26]. Such logistical and economic considerations are increasingly relevant in modern healthcare delivery. In a general sense, the elimination of operating room time, general anesthesia, and an overnight hospital stay indicates that the percutaneous procedure is substantially less resource-intensive and is likely associated with lower direct healthcare costs compared with the open procedure.

In our series, no postoperative stiffness, neurovascular or flexor tendon injuries occurred in either group, consistent with findings from recent large cohorts [12], 13]. Although the digital nerve course over the A1 pulley theoretically increases the risk of nerve injury during percutaneous release [14], careful technique with a midline entry point and controlled needle motion minimizes this risk. The recurrence rate remained low and was not statistically different between groups. We acknowledge that the difference in mean follow-up duration between the groups (49 months in the open group vs. 38 months in the percutaneous group) warrants consideration when interpreting recurrence rates. However, all recurrence events in our cohort were detected within the first 12 months after surgery, a period that was fully encompassed by the follow-up duration of both groups. Therefore, although the open group had a longer overall follow-up, this difference is unlikely to have substantially biased recurrence detection. In most cases, recurrence likely reflected incomplete pulley division rather than true regrowth, underscoring the importance of technical precision. These considerations are further supported by a 2024 systematic review and meta-analysis of 599 pediatric trigger thumbs, which reported that approximately 43.5 % of cases resolved spontaneously overall, with higher rates of resolution in cohorts followed for more than two years, underscoring the importance of follow-up duration when interpreting long-term outcomes and apparent recurrence rates after treatment [27].

This study has several limitations. Its retrospective design introduces a potential for selection bias; for instance, more complex or severe cases may have been directed toward open release. Although randomization was not performed, potential confounders such as age, sex, and laterality were adjusted for using multivariate analysis. Minor differences in follow-up duration between groups may have influenced recurrence detection. Moreover, standardized patient-reported outcome measures (PROMs) were not systematically collected. The assessment of functional outcome was therefore limited to parental reports of daily activities, general grip strength comparison, and objective range of motion findings, rather than utilizing validated instruments. This represents a notable limitation, as anatomical and mechanical results alone may not fully capture the patient’s functional experience or perceived treatment success. Finally, no cost analysis was performed, which could have provided valuable insights for healthcare policy and resource allocation.

Conclusions

Both open and percutaneous A1 pulley release are effective and safe for the treatment of pediatric trigger thumb. Open release remains the gold standard, offering excellent outcomes with minimal recurrence, while percutaneous release provides comparable results in selected patients, with the additional advantages of outpatient feasibility, avoidance of general anesthesia, and lower associated healthcare resource utilization. With meticulous technique and appropriate patient selection, percutaneous release represents a practical minimally invasive alternative to open surgery. Future prospective, randomized multicenter studies with larger, stratified cohorts are warranted to further refine patient selection criteria and optimize treatment algorithms.


Corresponding author: Soner Kocak, MD, Department of Orthopaedic and Traumatology, University of Health Sciences, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Türkiye, E-mail:

Acknowledgments

The authors wish to express their appreciation to their colleagues for their support and to all patients for their participation and cooperation in this study.

  1. Funding information: The authors declare that no financial support, grants, or other forms of assistance were received in the preparation of this manuscript.

  2. Author contributions: All authors contributed to the study conception and design. SK were responsible for the idea and concept of the paper. Material preparation, data collection and analysis were performed by SK, SKD. The first draft of the manuscript was written by SK and all authors commented on previous versions of the manuscript. SK, SKD critically reviewed and revised the manuscript. All authors read and approved the final manuscript.

  3. Conflict of interest: The authors report no conflicts of interest.

  4. Data availability statement: All data from this study are available upon reasonable request to the corresponding author.

  5. Ethical approval: The study adhered to the ethical principles outlined in the Declaration of Helsinki (1964). Approval was obtained from the Ethics Committee of Kanuni Sultan Suleyman Training and Research Hospital, Istanbul University of Health Sciences. Informed consent was obtained from all participants in the form of written consent.

  6. Informed consent: Informed consent was obtained from all participants prior to the collection of clinical and photographic data. Additionally, consent for the publication of personal data was secured before drafting the manuscript.

  7. Financial interests: The authors declare that they have no financial or non-financial interests to disclose.

  8. Artificial intelligence statement: No artificial intelligence was used for the writing of the submitted work.

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Received: 2025-10-12
Accepted: 2025-11-22
Published Online: 2025-12-19

© 2025 the author(s), published by De Gruyter, Berlin/Boston

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  14. Association between statin administration and outcome in patients with sepsis: A retrospective study
  15. Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
  16. A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
  17. Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
  18. Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
  19. Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
  20. Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
  21. Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
  22. The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
  23. Health literacy and health-related quality of life: The mediating role of irrational happiness
  24. Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
  25. Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
  26. Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
  27. Clinical analysis of ten cases of HIV infection combined with acute leukemia
  28. Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
  29. Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
  30. Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
  31. Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
  32. Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
  33. The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
  34. The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
  35. Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
  36. Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
  37. Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
  38. The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
  39. Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
  40. A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
  41. A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  42. Identifying early screening factors for depression in middle-aged and older adults: A cohort study
  43. Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
  44. Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
  45. High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
  46. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Investigation of the pathogenic variants induced Sjogren’s syndrome in Turkish population
  128. Nucleotide metabolic abnormalities in post-COVID-19 condition and type 2 diabetes mellitus patients and their association with endocrine dysfunction
  129. TGF-β–Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization
  130. Ultrasound-guided unilateral versus bilateral erector spinae plane block for postoperative analgesia of patients undergoing laparoscopic cholecystectomy
  131. Profiling gut microbiome dynamics in subacute thyroiditis: Implications for pathogenesis, diagnosis, and treatment
  132. Delta neutrophil index, CRP/albumin ratio, procalcitonin, immature granulocytes, and HALP score in acute appendicitis: Best performing biomarker?
  133. Anticancer activity mechanism of novelly synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative on colon cancer cells
  134. H2valdien3 arrests the cell cycle and induces apoptosis of gastric cancer
  135. Prognostic relevance of PRSS2 and its immune correlates in papillary thyroid carcinoma
  136. Association of SGLT2 inhibition with psychiatric disorders: A Mendelian randomization study
  137. Motivational interviewing for alcohol use reduction in Thai patients
  138. Luteolin alleviates oxygen-glucose deprivation/reoxygenation-induced neuron injury by regulating NLRP3/IL-1β signaling
  139. Polyphyllin II inhibits thyroid cancer cell growth by simultaneously inhibiting glycolysis and oxidative phosphorylation
  140. Relationship between the expression of copper death promoting factor SLC31A1 in papillary thyroid carcinoma and clinicopathological indicators and prognosis
  141. CSF2 polarized neutrophils and invaded renal cancer cells in vitro influence
  142. Proton pump inhibitors-induced thrombocytopenia: A systematic literature analysis of case reports
  143. The current status and influence factors of research ability among community nurses: A sequential qualitative–quantitative study
  144. OKAIN: A comprehensive oncology knowledge base for the interpretation of clinically actionable alterations
  145. The relationship between serum CA50, CA242, and SAA levels and clinical pathological characteristics and prognosis in patients with pancreatic cancer
  146. Identification and external validation of a prognostic signature based on hypoxia–glycolysis-related genes for kidney renal clear cell carcinoma
  147. Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility
  148. Relationship of resting echocardiography combined with serum micronutrients to the severity of low-gradient severe aortic stenosis
  149. Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial
  150. The diagnostic performance of machine learning-based FFRCT for coronary artery disease: A meta-analysis
  151. Comparing biofeedback device vs diaphragmatic breathing for bloating relief: A randomized controlled trial
  152. Serum uric acid to albumin ratio and C-reactive protein as predictive biomarkers for chronic total occlusion and coronary collateral circulation quality
  153. Multiple organ scoring systems for predicting in-hospital mortality of sepsis patients in the intensive care unit
  154. Single-cell RNA sequencing data analysis of the inner ear in gentamicin-treated mice via intraperitoneal injection
  155. Suppression of cathepsin B attenuates myocardial injury via limiting cardiomyocyte apoptosis
  156. Influence of sevoflurane combined with propofol anesthesia on the anesthesia effect and adverse reactions in children with acute appendicitis
  157. Identification of hub genes related to acute kidney injury caused by sevoflurane anesthesia and endoplasmic reticulum stress
  158. 10.1515/med-2025-1313
  159. 10.1515/med-2025-1316
  160. Health education pathway for individuals with temporary enterostomies using patient journey mapping
  161. 10.1515/med-2025-1321
  162. 10.1515/med-2025-1324
  163. 10.1515/med-2025-1325
  164. 10.1515/med-2025-1327
  165. 10.1515/med-2025-1331
  166. Effect of timing of cholecystectomy on weight loss after sleeve gastrectomy in morbidly obese individuals with cholelithiasis: a retrospective cohort study
  167. 10.1515/med-2025-1337
  168. 10.1515/med-2025-1347
  169. 10.1515/med-2025-1360
  170. Multiple sclerosis and type 1 diabetes: a Mendelian randomization study of European ancestry
  171. Rapid pathogen identification in peritoneal dialysis effluent by MALDI-TOF MS following blood culture enrichment
  172. Comparison of open and percutaneous A1 pulley release in pediatric trigger thumb: a retrospective cohort study
  173. Review Articles
  174. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  175. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  176. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  177. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  178. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  179. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  180. The application of augmented reality in robotic general surgery: A mini-review
  181. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  182. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  183. Plant polyphenols, terpenes, and terpenoids in oral health
  184. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  185. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  186. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  187. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  188. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  189. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  190. Giant borderline ovarian tumours – review of the literature
  191. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  192. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  193. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  194. Supplement strategies for infertility in overweight women: Evidence and legal insights
  195. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  196. A meta-analysis of the effects of DBS on cognitive function in patients with advanced PD
  197. Protective role of selenium in sepsis: Mechanisms and potential therapeutic strategies
  198. Strategies for hyperkalemia management in dialysis patients: A systematic review
  199. C-reactive protein-to-albumin ratio in peripheral artery disease
  200. 10.1515/med-2025-1251
  201. 10.1515/med-2025-1330
  202. 10.1515/med-2025-1332
  203. Antibiotic prescribing patterns in general dental practice- a scoping review
  204. Clinical and medico-legal reflections on non-invasive prenatal testing
  205. Case Reports
  206. Delayed graft function after renal transplantation
  207. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  208. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  209. Giant right atrial hemangioma presenting with ascites: A case report
  210. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  211. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  212. Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report
  213. Coronary artery anomalies: A case of the “malignant” left coronary artery and its surgical management
  214. Combined VAT and retroperitoneoscopy for pleural empyema due to nephro-pleuric fistula in xanthogranulomatous pyelonephritis
  215. 10.1515/med-2025-1362
  216. Rapid Communication
  217. Biological properties of valve materials using RGD and EC
  218. A single oral administration of flavanols enhances short-term memory in mice along with increased brain-derived neurotrophic factor
  219. Letter to the Editor
  220. Role of enhanced external counterpulsation in long COVID
  221. Expression of Concern
  222. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  223. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  224. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  225. Corrigendum
  226. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  227. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  228. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  229. Retraction
  230. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  231. Retraction of: “LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through downregulating SP-A by sponging to miR-424”
  232. Retraction of: “SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways”
  233. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  234. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  235. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  236. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  237. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  238. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  239. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  240. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  241. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  242. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  243. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  244. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  245. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  246. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  247. Red cell distribution width predicts early kidney injury: A NHANES cross-sectional study
  248. Special Issue Diabetes mellitus: pathophysiology, complications & treatment
  249. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  250. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  251. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  252. A review of brain research on T2DM-related cognitive dysfunction
  253. Metformin and estrogen modulation in LABC with T2DM: A 36-month randomized trial
  254. Special Issue Innovative Biomarker Discovery and Precision Medicine in Cancer Diagnostics
  255. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
Heruntergeladen am 19.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/med-2025-1364/html
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