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MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration

  • Mingyue Zhu , Guxin Zhou , Fangyuan Chang and Jin Liu EMAIL logo
Published/Copyright: May 13, 2025
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Open Medicine
From the journal Open Medicine Volume 20 Issue 1

Abstract

Background

The immune microenvironment of ovarian cancer is crucial in its progression. Recent studies highlight the significant role of MZB1 in shaping the tumor immune microenvironment (TIME), although its specific function in ovarian cancer remains unclear.

Materials and methods

We analyzed 381 ovarian cancer samples from the TCGA database, along with additional samples from GEO and single-cell datasets. Differentially expressed genes (DEGs) were identified using DESeq2. Various algorithms were applied to assess the relationship between MZB1 and the TIME. Cell proliferation was measured using the CCK-8 assay, while cell migration was evaluated using the wound healing assay. Furthermore, a nomogram predicting overall survival was developed based on multivariable Cox regression results.

Results

Our results indicated a positive correlation between high MZB1 expression and improved clinical prognosis. Additionally, higher MZB1 expression was linked to increased immune cell infiltration within the TIME. Elevated MZB1 levels inhibited the migration and proliferation of SKOV3 cells. The nomogram’s C-index was 0.702, and its calibration curve demonstrated good calibration, indicating satisfactory discrimination and accuracy in predicting patient outcomes.

Conclusions

This study comprehensively analyzes MZB1’s role in the TIME of ovarian cancer. MZB1 is a promising prognostic marker and a potential target for personalized treatment.

Graphical abstract

Keywords: ovarian cancer; MZB1; tumor immune microenvironment; immune infiltrate cell; nomogram

1 Introduction

Ovarian cancer is the deadliest malignancy among women, often diagnosed at an advanced stage with a poor prognosis [1]. Characterized by its elusive nature and early metastasis [2,3], the 5-year survival rate remains around 40% [4]. The high recurrence rate of 82% among advanced-stage ovarian cancer patients after treatment significantly affects their quality of life and imposes a substantial burden on societal resources [4,5,6].

Ovarian cancer treatments, including surgery, radiotherapy, and chemotherapy, are complemented by emerging therapies like PARP inhibitors, which extend survival in advanced-stage patients with BRCA1/2 mutations, and PD-1/PD-L1 inhibitors, which enhance immune responses against tumors [7,8,9,10,11,12]. Targeted therapies have proven to be effective in treating ovarian cancer. Therefore, the identification of novel clinical biomarkers could be instrumental in advancing our understanding of ovarian cancer’s diagnosis, prognosis, and treatment strategies.

Marginal zone B and B-1 cell-specific protein 1 (MZB1) is localized in the endoplasmic reticulum, playing critical roles in B-cell calcium homeostasis, cell motility, and integrin-mediated T-cell adhesion [13,14]. MZB1 is an immune-related protein, and its upregulation is associated with autoimmune diseases such as periodontitis, systemic lupus erythematosus, and multiple sclerosis [13]. Research on MZB1 in tumors has been relatively scarce, but it has recently been increasingly recognized. Wu et al. demonstrated that MZB1 acts as a tumor suppressor and is downregulated in colorectal cancer tumor tissues [15]. In primary gastric cancer, low MZB1 expression is correlated with a higher risk of recurrence following curative resection, as MZB1’s suppressive role links its reduced levels to increased hematogenous recurrence and changes in tumor progression-related gene expression [16]. Notably, as MZB1 was initially identified in immune cells, its role in the regulation of the TIME warrants close attention. While research on MZB1 in cancer-related diseases holds significant promise, regrettably, its role in ovarian cancer remains unexplored. We hypothesize that MZB1 may be a critical target influencing the progression of ovarian cancer. Therefore, further studies are urgently needed to elucidate the function and underlying mechanisms of MZB1 in this context.

In this study, we leveraged the TCGA, GEO, and other databases to comprehensively analyze MZB1, including its expression patterns, associations with survival outcomes, genetic alterations, immune infiltration, and involvement in cellular pathways. Furthermore, CCK8 and wound healing assays were performed to evaluate the impact of MZB1 on cellular phenotypes, providing insights into its functional roles and potential mechanisms in the pathogenesis and clinical prognosis of ovarian cancer. This comprehensive analysis aims to uncover MZB1’s potential as a biomarker and therapeutic target, paving the way for improved personalized treatment strategies.

2 Materials and methods

2.1 Data collection and pre-processing

We obtained RNA sequencing data and corresponding clinical follow-up information for 381 samples from the TCGA database (excluded if clinicopathological information is missing). The RNAseq data, initially in FPKM format, were converted to TPM format and log2-transformed. Duplicate samples were excluded to retain relevant clinical information. Two GEO database platforms (GPL570 and GPL96) were used to validate the MZB1 expression.

2.2 Protein–protein interaction (PPI) networks

To understand MZB1’s functions and efficacy, we constructed a PPI network using the STRING database (https://cn.string-db.org). We set a minimum interaction score of 0.7, with interaction predictions based on experimental evidence and curated databases, allowing visualization and exploration of MZB1’s interactions and potential roles.

2.3 Differential expression and survival analysis of MZB1

We obtained RNA-seq data for ovarian cancer patients from the TCGA database and normal ovarian tissue samples from the GTEx project via UCSC Xena. Kaplan–Meier survival analysis was performed to evaluate the correlation between MZB1 expression levels and patient prognosis. The log-rank test was used to analyze the differences in OS, PFI, and DSS.

2.4 Immune infiltration analysis

Immune cell infiltration and gene expression regulation were analyzed using TIMER, quantifying six immune cell types per sample. CIBERSORT was used to calculate relative scores for 24 immune cell types, predicting immunocyte phenotypes. The correlation between MZB1 and immune cell infiltration was assessed using the xCell algorithm.

2.5 Gene Set Enrichment Analysis (GSEA)

GSEA was conducted employing the “clusterProfiler” R package to explore biological signaling pathways in the high- and low-expression groups of MZB1. The top five pathways were identified and presented. The enrichment results were based on the net enrichment score (NES), false discovery rate (FDR), and p-value. Gene sets meeting the criteria of |NES| > 1, adjusted p-value < 0.05, and FDR q-value < 0.25 were considered statistically significant.

2.6 Single-cell transcriptome analysis

We employed the publicly available online database Tumor Immune Single-cell Hub 2 (TISCH2, http://tisch.comp-genomics.org/home/) for the single-cell transcriptome analysis of pre-existing data. TISCH2 provides comprehensive cell-type annotation at the single-cell level, facilitating the investigation of the TIME in various cancer types.

2.7 Cell culture

Ovarian cancer SKOV3 cells were cultured in DMEM supplemented with 10% fetal bovine serum (FBS), 100 IU/mL penicillin, and 10 µg/mL streptomycin at 37°C in a humidified atmosphere with 5% CO2.

2.8 Cell transfection

MZB1 shRNA targeting sequence: shMZB1: 5′-GGACUACGGAGUUCGAGAATT-3′. SKOV3 cells were transfected with MZB1 shRNA or scrambled shRNA plasmids using ExFect Transfection Reagent (Vazyme) at 37°C for 24 h. Human MZB1 cDNA (XM_054352720) was amplified and inserted into pLV6ltr-ZsGreen-Puro-CMV, followed by transfection using ExFect Transfection Reagent.

2.9 Cell proliferation assay (CCK-8)

Transfected SKOV3 cells were seeded into 96-well plates (1 × 104 cells/well) and incubated at 37°C, 5% CO2. At 0, 24, 48, 72, 96, and 120 h, the medium was replaced with 90 μl of fresh medium and 10 μl of CCK-8 (APExBIO; Cat. No. K1018) per well. After incubation at 37°C, the OD values at 450 nm were measured using a microplate reader to evaluate cell proliferation.

2.10 Migration assay

For the wound healing assay, 5 × 105 cells were plated in 6-well plates. A scratch was made using a 20 μm pipette tip, and cells were washed with DMEM and incubated at 37°C for 24 h. Images were taken at 0 and 24 h to document wound closure.

2.11 Western blot

Cells were homogenized and sonicated in ice-cold RIPA buffer. Proteins were extracted, denatured, and separated on a 12.5% SDS-PAGE gel. Membranes were incubated overnight at 4°C with primary antibodies (MZB1, Proteintech; 1:1,000), followed by 1 h at room temperature with secondary antibodies (Goat Anti-Rat IgG; Biosharp; 1:10,000). Chemiluminescence was used for detection.

2.12 Construction and verification of nomogram

Variables with p-values ≤ 0.1 in univariate analysis were included in multivariate Cox regression. Independent prognostic factors (p < 0.05) were used to construct nomograms. The C-index assessed discriminative performance, and calibration curves evaluated nomogram accuracy.

2.13 Statistics

Statistical analyses and graphical presentations were conducted utilizing R software (version 4.1) equipped with the “ggplot2” and “ggpubr” packages. The false discovery rate (FDR) method was applied to adjust p values. For categorical data, the chi-square test was employed, whereas Wilcoxon’s rank-sum test and Student’s t-test were utilized for assessing continuous variables. Correlation analysis was performed using the Spearman method. Significance levels were indicated as follows: ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05, and ns for non-significant results.

  1. Ethics approval and informed consent: Not applicable.

3 Results

3.1 Elevated expression of MZB1 is associated with a favorable prognosis

MZB1 expression was upregulated in ovarian cancer tissues compared to normal ovarian tissues (Figure 1a; Figure S1a and b). High expression was associated with better OS (Figure 1b), and patients with high expression had longer disease-specific survival (DSS) and progression-free interval (PFI) compared to those with low expression (Figure 1c and d). This suggests that high MZB1 expression is linked to a favorable prognosis in patients, indicating its potential as a prognostic marker. In TCGA tumor samples, ovarian cancer had the highest frequency of MZB1 genetic alterations, primarily amplifications (Figure 2a). Figure 2b shows the sites of MZB1 genetic alterations, including the R163L/Q alteration (Figure 2c). However, ovarian cancer cases with MZB1 alterations showed no OS advantage compared to those without alterations (log rank p = 0.964, Figure S1c). These findings suggest that higher MZB1 expression predicts better patient prognosis, while MZB1 gene alterations do not affect its role in ovarian cancer progression.

Figure 1 MZB1 expression levels in ovarian cancer and its impact on prognosis: (a) expression of MZB1 in tumor tissues and corresponding normal tissues; and (b)–(d) Kaplan–Meier curves show that lower expression of MZB1 is associated with poorer prognosis. ***p < 0.001.
Figure 1

MZB1 expression levels in ovarian cancer and its impact on prognosis: (a) expression of MZB1 in tumor tissues and corresponding normal tissues; and (b)–(d) Kaplan–Meier curves show that lower expression of MZB1 is associated with poorer prognosis. ***p < 0.001.

Figure 2 Mutation features of MZB1 in pan-cancer: (a) alteration frequency with mutation type of MZB1; (b) alteration mutation site of MZB1 genetic alteration; and (c) the mutation site with the highest alteration frequency (R163L/Q) in the 3D structure of MZB1.
Figure 2

Mutation features of MZB1 in pan-cancer: (a) alteration frequency with mutation type of MZB1; (b) alteration mutation site of MZB1 genetic alteration; and (c) the mutation site with the highest alteration frequency (R163L/Q) in the 3D structure of MZB1.

3.2 MZB1 is involved in DNA damage response and cell cycle regulation

Using DEseq2, we identified 3,510 upregulated and 5,173 downregulated genes associated with MZB1 expression (Figure 3a). GSEA revealed that these genes are involved in DNA damage response and cell cycle regulation pathways (Figure 3b) and potentially in steroid hormone response, HIPPO, and WNT pathways (Figure 3c). These pathways are associated with immunity and tumor proliferation, suggesting that MZB1 may regulate tumor progression by modulating immune responses and tumor proliferation. Additionally, the PPI network indicated that MZB1 interacts mainly with proteins related to the cell cycle and endoplasmic reticulum stress (Figure S1d). Therefore, differences in endoplasmic reticulum stress-related proteins were analyzed under different MZB1 expression states (Figure S2a). The relationship between MZB1 and endoplasmic reticulum stress has not been reported, warranting further experimental investigation. These findings highlight MZB1’s role in targeted and immunotherapy strategies. This also provides a direction for future in-depth mechanistic studies.

Figure 3 MZB1 is involved in multiple signaling pathway responses: (a) differentially expressed genes shown by volcano plot; (b) GSEA pathways related to DEGs; and (c) impact of pathway mutations on MZB1 expression.
Figure 3

MZB1 is involved in multiple signaling pathway responses: (a) differentially expressed genes shown by volcano plot; (b) GSEA pathways related to DEGs; and (c) impact of pathway mutations on MZB1 expression.

3.3 MZB1 has been detected in ovarian cancer cells

Single-cell analysis of the ovarian cancer dataset GSE154600 showed MZB1 expression in both ovarian cancer cells and immune cells, predominantly plasma cells, with relatively lower expression in tumor cells (Figure 4a–c). This explains the high MZB1 expression observed in bulk RNA sequencing of ovarian cancer tissues. MZB1 in ovarian cancer cells may directly impact tumor cells, while MZB1 in immune cells may indirectly influence tumor progression by regulating the function of the respective cells. Further analysis in multiple ovarian cancer single-cell databases confirmed these findings (Figure S2b). MZB1 exhibited broader expression in ovarian clear cell carcinoma compared to other ovarian cancer types (Figure S2c; Table S1), highlighting the importance of further investigating its role in this particular subtype of ovarian cancer. The results suggest that MZB1 may regulate ovarian cancer progression through multiple mechanisms by influencing both ovarian cancer cells and immune cells in the TIME.

Figure 4 Expression of MZB1 in tumor cells and immune cells: (a) single-cell annotation plot; (b) single-cell expression of MZB1 in OV cohorts; and (c) grid violin plot detailing the average expression distribution of MZB1 on each type of cell (tumor, immune, and stromal cells).
Figure 4

Expression of MZB1 in tumor cells and immune cells: (a) single-cell annotation plot; (b) single-cell expression of MZB1 in OV cohorts; and (c) grid violin plot detailing the average expression distribution of MZB1 on each type of cell (tumor, immune, and stromal cells).

3.4 MZB1 plays a crucial role in the TIME of ovarian cancer

Using ESTIMATE, TIMER, XCELL, and CIBERSORT algorithms, we investigated the correlation between MZB1 and various immune cells in the ovarian cancer microenvironment (Figure 5a and b; Figure S3a and b). These cells play a crucial role in the tumor microenvironment and are an essential component of the TIME. MZB1 showed significant positive correlations with B cells, T cells, and dendritic cells (Figure S3c and d), which often exert anti-tumor effects. High MZB1 expression correlated with increased immune cell infiltration and higher immune scores, suggesting MZB1’s positive regulatory role in the tumor immune response, explaining the better prognosis for patients with high MZB1 expression.

Figure 5 MZB1 is closely associated with the immune microenvironment. Estimate (a) and Timer (b) algorithms were used to calculate the correlation between MZB1 expression and immune cells. Spearman; **p < 0.01; ****p < 0.0001.
Figure 5

MZB1 is closely associated with the immune microenvironment. Estimate (a) and Timer (b) algorithms were used to calculate the correlation between MZB1 expression and immune cells. Spearman; **p < 0.01; ****p < 0.0001.

3.5 MZB1 inhibits the migration of SKOV3 by affecting its proliferation

To investigate the role of MZB1 in ovarian cancer cells, we conducted cellular assays. CCK-8 assay showed that MZB1 significantly affected SKOV3 cell proliferation (Figure 6a). Overexpression of MZB1 inhibited cell proliferation, while knockdown of MZB1 enhanced proliferative capacity. Wound healing assays demonstrated that MZB1 knockdown enhanced SKOV3 cell migration, while overexpression inhibited migration (Figure 6b). The results indicate that MZB1 within tumor cells plays a role in suppressing tumor proliferation and migration, functioning as a tumor suppressor gene.

Figure 6 MZB1 inhibits the migration and proliferation of SKOV3 cells: (a) proliferative ability of SKOV3 assessed by CCK-8 assay; and (b) wound-healing assays were conducted at 0 and 24 h in SKOV3 cells with MZB1 overexpression or knockdown. N = 3; *p < 0.05; **p < 0.01; ns.: no significance.
Figure 6

MZB1 inhibits the migration and proliferation of SKOV3 cells: (a) proliferative ability of SKOV3 assessed by CCK-8 assay; and (b) wound-healing assays were conducted at 0 and 24 h in SKOV3 cells with MZB1 overexpression or knockdown. N = 3; *p < 0.05; **p < 0.01; ns.: no significance.

3.6 miR-1193 is a potential upstream regulatory molecule

Using TargetScan and mirDIP prediction tools, we identified miR-1193 as a potential upstream regulator of MZB1 (Figure S4a and b). miR-1193 is implicated in various biological processes and may modulate MZB1 expression. Further studies are needed to elucidate the molecular mechanisms underlying miR-1193’s regulation of MZB1 and its role in cancer pathways.

3.7 Exploration of the clinical application value of MZB1

We explored MZB1’s clinical potential and found it valuable (AUC > 0.70) for diagnosing ovarian cancer (Figure 7a). Cox regression analysis identified MZB1 as an independent prognostic factor (Figure 7b). A prognostic nomogram based on multivariable Cox regression analysis demonstrated good discriminatory ability (C-index: 0.702, 0.680–0.724) and satisfactory calibration (Figure 7c and d). This indicates that we have preliminarily developed a prognostic prediction model with clinical application value. MZB1 holds significant clinical application potential in ovarian cancer.

Figure 7 The clinical value of MZB1: (a) diagnostic efficacy of MZB1 in ovarian cancer; (b) Forest plot showing MZB1 as an independent prognostic factor; (c) establishment of OS nomogram; and (d) calibration curve for nomogram predictions.
Figure 7

The clinical value of MZB1: (a) diagnostic efficacy of MZB1 in ovarian cancer; (b) Forest plot showing MZB1 as an independent prognostic factor; (c) establishment of OS nomogram; and (d) calibration curve for nomogram predictions.

4 Discussion

The present study establishes MZB1 as a novel prognostic biomarker and therapeutic target in ovarian cancer through multi-omics analyses and experimental validation. Our findings reveal three key aspects of MZB1’s involvement in ovarian carcinogenesis: (1) its tumor-suppressive functions through direct modulation of cancer cell proliferation/migration, (2) its critical immunomodulatory role within the TIME, and (3) its unique expression patterns in chemoresistant histological subtypes, particularly ovarian clear cell carcinoma (OCCC). These insights significantly extend the current understanding of MZB1’s multifaceted roles beyond its established functions in autoimmune diseases and other malignancies [13,15,16].

The clinical potential of MZB1 deserves substantial attention, particularly in early disease diagnosis and prognostic prediction, areas that remain significantly underexplored in current research [17,18,19]. Our multi-omics approach demonstrated that elevated MZB1 expression correlates with improved OS, DSS, and PFI. This prognostic value remained significant after adjusting for clinicopathological variables in multivariate Cox regression, indicating MZB1’s potential as an independent prognostic marker. The functional basis for this observation was elucidated through in vitro experiments showing that MZB1 knockdown enhances SKOV3 cell proliferation and migration, while overexpression exerts the opposite effects. These results collectively position MZB1 as a tumor suppressor in ovarian cancer. High MZB1 expression is an independent favorable prognostic factor, also attributable to its positive regulation within the ovarian cancer immune microenvironment [20,21]. Therefore, it is crucial to investigate the features of TIME, immune status, and relevant immunotherapy approaches to better understand the regulatory mechanisms of the immune microenvironment, enabling precise immune intervention in tumors [22,23].

The TIME dynamically regulates MZB1 activity, which in turn modulates cancer cell behavior [24,25]. Interestingly, the observed upregulation of MZB1 in various tumors presents an apparent paradox, given its documented tumor-suppressive properties. This phenomenon may be resolved by considering MZB1’s dual functionality in immune regulation – while it directly suppresses malignant cell migration through cancer cell-intrinsic mechanisms [26], it simultaneously engages in immunomodulatory processes within the TIME. Our single-cell analysis revealed MZB1 expression in both tumor cells and immune subsets, while bulk RNA-seq correlations with immune infiltration scores suggest dual roles in cancer cell biology and immune modulation. Elevated MZB1 expression in plasma cells, T cells, and other immune cells in the TIME contributes to anti-tumor effects and inhibits tumor progression [27,28]. Specifically, MZB1 showed strong positive associations with anti-tumor immune populations, including CD8+ T cells (p < 0 .001) and dendritic cells (p < 0.001). The elevated immune scores in MZB1-high tumors further support its role in fostering an immunocompetent TIME, which may synergize with checkpoint inhibitors – a hypothesis requiring validation in immunotherapy trials. Moreover, MZB1 may exert an anti-tumor effect by activating the complement system, which aligns with its role in various tumors [29].

A particularly intriguing finding was the elevated MZB1 expression in OCCC, a subtype characterized by platinum resistance and poor outcomes [30]. OCCC exhibits intrinsic resistance to platinum-based therapy, with chemotherapy response rates ranging from 11 to 56%, highlighting the need for advancements in targeted and immunotherapy for this subtype [31]. Our analysis revealed high MZB1 expression across various ovarian cancer cell lines, particularly in OCCC, which contrasts with our understanding that MZB1 is predominantly distributed in immune cells [32,33]. Our pathway analysis showing MZB1’s involvement in HIPPO and WNT signaling provides a plausible mechanism, as these pathways are frequently dysregulated in OCCC. Notably, our GSEA links phenotypic changes to MZB1’s regulation of DNA damage response and cell cycle pathways, which aligns with recent findings in colorectal cancer, where MZB1 deficiency promotes genomic instability [15]. MZB1 is associated with DNA repair pathways [34,35]. Altered expression of MZB1 in tumor cells is associated with DNA damage response and cell cycle regulation, highlighting its multifaceted roles in ovarian cancer and suggesting its potential as a therapeutic target [36]. PARPi exhibits their effects against tumors with DNA repair deficiencies [37]. MZB1’s association with DNA damage repair response indicates its potential to predict PARPi efficacy [38]. Developing drugs targeting MZB1, in combination with PARPi, could improve treatment outcomes for OCCC [39]. Furthermore, combining immune checkpoint inhibitors with PARPi holds promise, and MZB1 may serve as a predictive marker for this combination therapy [40].

Despite these advances, our study has limitations. First, the overrepresentation of high-grade serous carcinoma in the TCGA cohort necessitates validation in larger cohorts. Second, the in vitro findings require confirmation through in vivo models and mechanistic studies to delineate MZB1’s precise roles in DNA repair versus immune modulation. Third, the clinical applicability of the proposed nomogram needs external validation across diverse populations.

5 Conclusion

In conclusion, MZB1 can inhibit tumor cell proliferation and migration, thereby impacting ovarian cancer prognosis and correlating with immune infiltration. Our study elucidates the multifaceted roles of MZB1 in ovarian cancer cells and the TIME, providing experimental evidence that supports its potential as a therapeutic target. We developed a prognostic model incorporating MZB1, significantly enhancing predictive accuracy for patient outcomes and providing clinicians with powerful tools to develop tailored treatment strategies. Moving forward, we anticipate that further research will clarify the specific mechanisms by which MZB1 influences ovarian cancer progression, ultimately advancing its clinical translation and application in ovarian cancer treatment.

# These authors contributed equally to this work and share first authorship.

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Acknowledgements

We express our sincere gratitude to Xiantao Academic and SangerBox for their invaluable assistance with data visualization.

  1. Funding information: This work was supported by Jiangsu Medical College University-Community Collaborative Innovation Research Project (grant number 202490504). General Program of the Yancheng Health Commission (grant number YK2024218).

  2. Author contributions: JL conceived and designed the study. MZ and GZ analyzed and interpreted the data. FC was responsible for the materials. MZ drafted the article. JL revised the article critically. All authors approved the final draft of the manuscript.

  3. Conflict of interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

  4. Data availability statement: Details and data that support the findings of this study are available from the corresponding author upon request.

References

[1] Kuroki L, Guntupalli SR. Treatment of epithelial ovarian cancer. BMJ. 2020;371:m3773.10.1136/bmj.m3773Search in Google Scholar PubMed

[2] Gao J, Han W, He Y, Zhou J, Miao J, Zhang G. Livin promotes tumor progression through YAP activation in ovarian cancer. Am J Cancer Res. 2020;10(10):3179–93.Search in Google Scholar

[3] Konstantinopoulos PA, Matulonis UA. Clinical and translational advances in ovarian cancer therapy. Nat Cancer. 2023;4(9):1239–57.10.1038/s43018-023-00617-9Search in Google Scholar PubMed

[4] Wang Z, Zhang W, Fang J, Xie P, Miao M, Yang H. Circular RNA circEXOC6B inhibits the progression of ovarian cancer by sponging miR-421 and regulating RUS1 expression. Onco Targets Ther. 2020;13:8233–43.10.2147/OTT.S243040Search in Google Scholar PubMed PubMed Central

[5] Coleman RL, Monk BJ, Sood AK, Herzog TJ. Latest research and treatment of advanced-stage epithelial ovarian cancer. Nat Rev Clin Oncol. 2013;10(4):211–24.10.1038/nrclinonc.2013.5Search in Google Scholar PubMed PubMed Central

[6] Del CJ, Matulonis UA, Malander S, Provencher D, Mahner S, Follana P, et al. Niraparib maintenance therapy in patients with recurrent ovarian cancer after a partial response to the last platinum-based chemotherapy in the ENGOT-OV16/NOVA trial. J Clin Oncol. 2019;37(32):2968–73.10.1200/JCO.18.02238Search in Google Scholar PubMed PubMed Central

[7] Gonzalez-Martin A, Pothuri B, Vergote I, Graybill W, Lorusso D, McCormick CC, et al. Progression-free survival and safety at 3.5 years of follow-up: results from the randomised phase 3 PRIMA/ENGOT-OV26/GOG-3012 trial of niraparib maintenance treatment in patients with newly diagnosed ovarian cancer. Eur J Cancer. 2023;189:112908.10.1016/j.ejca.2023.04.024Search in Google Scholar PubMed

[8] Kim H, Xu H, George E, Hallberg D, Kumar S, Jagannathan V, et al. Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models. Nat Commun. 2020;11(1):3726.10.1038/s41467-020-17127-2Search in Google Scholar PubMed PubMed Central

[9] Wethington SL, Shah PD, Martin L, Tanyi JL, Latif N, Morgan M, et al. Combination ATR (ceralasertib) and PARP (olaparib) inhibitor (CAPRI) trial in acquired PARP inhibitor-resistant homologous recombination-deficient ovarian cancer. Clin Cancer Res. 2023;29(15):2800–7.10.1158/1078-0432.c.6696342.v1Search in Google Scholar

[10] Lee EK, Matulonis UA. Emerging drugs for the treatment of ovarian cancer: A focused review of PARP inhibitors. Expert Opin Emerg Drugs. 2020;25(2):165–88.10.1080/14728214.2020.1773791Search in Google Scholar PubMed

[11] Peng Z, Li M, Li H, Gao Q. PD-1/PD-L1 immune checkpoint blockade in ovarian cancer: Dilemmas and opportunities. Drug Discov Today. 2023;28(8):103666.10.1016/j.drudis.2023.103666Search in Google Scholar PubMed

[12] Konstantinopoulos PA, Waggoner S, Vidal GA, Mita M, Moroney JW, Holloway R, et al. Single-arm phases 1 and 2 trial of niraparib in combination with pembrolizumab in patients with recurrent platinum-resistant ovarian carcinoma. JAMA Oncol. 2019;5(8):1141–9.10.1001/jamaoncol.2019.1048Search in Google Scholar PubMed PubMed Central

[13] Wei H, Wang JY. Role of polymeric immunoglobulin receptor in IgA and IgM transcytosis. Int J Mol Sci. 2021;22(5):2284.10.3390/ijms22052284Search in Google Scholar PubMed PubMed Central

[14] Suzuki K, Vogelzang A, Fagarasan S. MZB1 folding and unfolding the role of IgA. Proc Natl Acad Sci U S A. 2019;116(27):13163–5.10.1073/pnas.1908012116Search in Google Scholar PubMed PubMed Central

[15] Wu W, Yang Z, Long F, Luo L, Deng Q, Wu J, et al. COL1A1 and MZB1 as the hub genes influenced the proliferation, invasion, migration and apoptosis of rectum adenocarcinoma cells by weighted correlation network analysis. Bioorg Chem. 2020;95:103457.10.1016/j.bioorg.2019.103457Search in Google Scholar PubMed

[16] Kanda M, Tanaka C, Kobayashi D, Tanaka H, Shimizu D, Shibata M, et al. Epigenetic suppression of the immunoregulator MZB1 is associated with the malignant phenotype of gastric cancer. Int J Cancer. 2016;139(10):2290–8.10.1002/ijc.30286Search in Google Scholar PubMed

[17] Yi C, Yang J, Zhang T, Qin L, Chen D. Identification of breast cancer subtypes based on endoplasmic reticulum stress-related genes and analysis of prognosis and immune microenvironment in breast cancer patients. Technol Cancer Res Treat. 2024;23:15330338241241484.10.1177/15330338241241484Search in Google Scholar PubMed PubMed Central

[18] Chanukuppa V, Paul D, Taunk K, Chatterjee T, Sharma S, Shirolkar A, et al. Proteomics and functional study reveal marginal zone B and B1 cell specific protein as a candidate marker of multiple myeloma. Int J Oncol. 2020;57(1):325–37.10.3892/ijo.2020.5056Search in Google Scholar PubMed

[19] Tang Y, Feng X, Lu Q, Cui C, Yu M, Wen Z, et al. MZB1-mediated IgA secretion suppresses the development and progression of colorectal cancer triggered by gut inflammation. Mucosal Immunol. 2024;17(3):450–60.10.1016/j.mucimm.2023.12.002Search in Google Scholar PubMed

[20] Blanc-Durand F, Clemence WXL, Tan D. Targeting the immune microenvironment for ovarian cancer therapy. Front Immunol. 2023;14:1328651.10.3389/fimmu.2023.1328651Search in Google Scholar PubMed PubMed Central

[21] Almeida-Nunes DL, Mendes-Frias A, Silvestre R, Dinis-Oliveira RJ, Ricardo S. Immune tumor microenvironment in ovarian cancer ascites. Int J Mol Sci. 2022;23(18):10692.10.3390/ijms231810692Search in Google Scholar PubMed PubMed Central

[22] Yang C, Xia BR, Zhang ZC, Zhang YJ, Lou G, Jin WL. Immunotherapy for ovarian cancer: Adjuvant, combination, and neoadjuvant. Front Immunol. 2020;11:577869.10.3389/fimmu.2020.577869Search in Google Scholar PubMed PubMed Central

[23] Jiang Y, Wang C, Zhou S. Targeting tumor microenvironment in ovarian cancer: Premise and promise. Biochim Biophys Acta Rev Cancer. 2020;1873(2):188361.10.1016/j.bbcan.2020.188361Search in Google Scholar PubMed

[24] Pitt JM, Marabelle A, Eggermont A, Soria JC, Kroemer G, Zitvogel L. Targeting the tumor microenvironment: Removing obstruction to anticancer immune responses and immunotherapy. Ann Oncol. 2016;27(8):1482–92.10.1093/annonc/mdw168Search in Google Scholar PubMed

[25] Xiao Y, Yu D. Tumor microenvironment as a therapeutic target in cancer. Pharmacol Ther. 2021;221:107753.10.1016/j.pharmthera.2020.107753Search in Google Scholar PubMed PubMed Central

[26] Li D, Zhu Y, Zhang L, Shi L, Deng L, Ding Z, et al. MZB1 targeted by miR-185-5p inhibits the migration of human periodontal ligament cells through NF-kappaB signaling and promotes alveolar bone loss. J Periodontal Res. 2022;57(4):811–23.10.1111/jre.13014Search in Google Scholar PubMed

[27] Yang L, Xiong J, Li S, Liu X, Deng W, Liu W, et al. Mitochondrial metabolic reprogramming-mediated immunogenic cell death reveals immune and prognostic features of clear cell renal cell carcinoma. Front Oncol. 2023;13:1146657.10.3389/fonc.2023.1146657Search in Google Scholar PubMed PubMed Central

[28] Gu S, Qian L, Zhang Y, Chen K, Li Y, Wang J, et al. Significance of intratumoral infiltration of B cells in cancer immunotherapy: From a single cell perspective. Biochim Biophys Acta Rev Cancer. 2021;1876(2):188632.10.1016/j.bbcan.2021.188632Search in Google Scholar PubMed

[29] Xu H, Li W, Zhu C, Cheng N, Li X, Hao F, et al. Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney. J Pathol. 2022;257(1):53–67.10.1002/path.5869Search in Google Scholar PubMed PubMed Central

[30] Sun Y, Liu G. Endometriosis-associated Ovarian Clear Cell Carcinoma: A Special Entity? J Cancer. 2021;12(22):6773–86.10.7150/jca.61107Search in Google Scholar PubMed PubMed Central

[31] Khalique S, Lord CJ, Banerjee S, Natrajan R. Translational genomics of ovarian clear cell carcinoma. Semin Cancer Biol. 2020;61:121–31.10.1016/j.semcancer.2019.10.025Search in Google Scholar PubMed

[32] Flach H, Rosenbaum M, Duchniewicz M, Kim S, Zhang SL, Cahalan MD, et al. Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells. Immunity. 2010;33(5):723–35.10.1016/j.immuni.2010.11.013Search in Google Scholar PubMed PubMed Central

[33] Kapoor T, Corrado M, Pearce EL, Pearce EJ, Grosschedl R. MZB1 enables efficient interferon alpha secretion in stimulated plasmacytoid dendritic cells. Sci Rep. 2020;10(1):21626.10.1038/s41598-020-78293-3Search in Google Scholar PubMed PubMed Central

[34] Xie Y, Kong W, Luo D, Chen S, Zhao X, Zhang HE. Ovarian clear cell carcinoma: Genomic characterization, pathogenesis and targeted therapy. Anticancer Res. 2023;43(8):3401–10.10.21873/anticanres.16515Search in Google Scholar PubMed

[35] Wong O, Li J, Cheung A. Targeting DNA damage response pathway in ovarian clear cell carcinoma. Front Oncol. 2021;11:666815.10.3389/fonc.2021.666815Search in Google Scholar PubMed PubMed Central

[36] Mirza-Aghazadeh-Attari M, Ostadian C, Saei AA, Mihanfar A, Darband SG, Sadighparvar S, et al. DNA damage response and repair in ovarian cancer: Potential targets for therapeutic strategies. DNA Repair (Amst). 2019;80:59–84.10.1016/j.dnarep.2019.06.005Search in Google Scholar PubMed

[37] Washington CR, Moore KN. Resistance to poly (ADP-ribose) polymerase inhibitors (PARPi): Mechanisms and potential to reverse. Curr Oncol Rep. 2022;24(12):1685–93.10.1007/s11912-022-01337-6Search in Google Scholar PubMed

[38] Jurkovicova D, Neophytou CM, Gasparovic AC, Goncalves AC. DNA damage response in cancer therapy and resistance: Challenges and opportunities. Int J Mol Sci. 2022;23(23):2284.10.3390/ijms232314672Search in Google Scholar PubMed PubMed Central

[39] O’Malley DM, Krivak TC, Kabil N, Munley J, Moore KN. PARP inhibitors in ovarian cancer: A review. Target Oncol. 2023;18(4):471–503.10.1007/s11523-023-00970-wSearch in Google Scholar PubMed PubMed Central

[40] Wu Z, Cui P, Tao H, Zhang S, Ma J, Liu Z, et al. The synergistic effect of PARP inhibitors and immune checkpoint inhibitors. Clin Med Insights Oncol. 2021;15:1179554921996288.10.1177/1179554921996288Search in Google Scholar PubMed PubMed Central

Received: 2024-09-06
Revised: 2025-03-02
Accepted: 2025-03-05
Published Online: 2025-05-13

© 2025 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Articles in the same Issue

  1. Research Articles
  2. Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
  3. Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
  4. Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
  5. Risk factors for severe adverse drug reactions in hospitalized patients
  6. Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
  7. Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
  8. CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
  9. Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
  10. Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
  11. Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
  12. Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
  13. Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
  14. Association between statin administration and outcome in patients with sepsis: A retrospective study
  15. Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
  16. A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
  17. Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
  18. Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
  19. Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
  20. Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
  21. Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
  22. The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
  23. Health literacy and health-related quality of life: The mediating role of irrational happiness
  24. Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
  25. Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
  26. Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
  27. Clinical analysis of ten cases of HIV infection combined with acute leukemia
  28. Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
  29. Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
  30. Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
  31. Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
  32. Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
  33. The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
  34. The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
  35. Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
  36. Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
  37. Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
  38. The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
  39. Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
  40. A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
  41. A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  42. Identifying early screening factors for depression in middle-aged and older adults: A cohort study
  43. Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
  44. Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
  45. High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
  46. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
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  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
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  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Review Articles
  128. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  129. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  130. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  131. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  132. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  133. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  134. The application of augmented reality in robotic general surgery: A mini-review
  135. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  136. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  137. Plant polyphenols, terpenes, and terpenoids in oral health
  138. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  139. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  140. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  141. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  142. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  143. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  144. Giant borderline ovarian tumours – review of the literature
  145. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  146. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  147. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  148. Supplement strategies for infertility in overweight women: Evidence and legal insights
  149. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  150. Case Reports
  151. Delayed graft function after renal transplantation
  152. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  153. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
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  156. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  157. Rapid Communication
  158. Biological properties of valve materials using RGD and EC
  159. Letter to the Editor
  160. Role of enhanced external counterpulsation in long COVID
  161. Expression of Concern
  162. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  163. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  164. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  165. Corrigendum
  166. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  167. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  168. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  169. Retraction
  170. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  171. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  172. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  173. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  174. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  175. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  176. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  177. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  178. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  179. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  180. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  181. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  182. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  183. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  184. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  185. Special Issue Diabetes
  186. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  187. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  188. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  189. A review of brain research on T2DM-related cognitive dysfunction
  190. Special Issue Biomarker Discovery and Precision Medicine
  191. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
https://doi.org/10.1515/med-2025-1174
Keywords for this article
ovarian cancer; MZB1; tumor immune microenvironment; immune infiltrate cell; nomogram
Creative Commons
BY 4.0

Articles in the same Issue

  1. Research Articles
  2. Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
  3. Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
  4. Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
  5. Risk factors for severe adverse drug reactions in hospitalized patients
  6. Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
  7. Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
  8. CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
  9. Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
  10. Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
  11. Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
  12. Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
  13. Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
  14. Association between statin administration and outcome in patients with sepsis: A retrospective study
  15. Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
  16. A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
  17. Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
  18. Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
  19. Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
  20. Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
  21. Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
  22. The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
  23. Health literacy and health-related quality of life: The mediating role of irrational happiness
  24. Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
  25. Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
  26. Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
  27. Clinical analysis of ten cases of HIV infection combined with acute leukemia
  28. Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
  29. Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
  30. Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
  31. Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
  32. Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
  33. The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
  34. The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
  35. Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
  36. Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
  37. Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
  38. The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
  39. Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
  40. A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
  41. A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  42. Identifying early screening factors for depression in middle-aged and older adults: A cohort study
  43. Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
  44. Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
  45. High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
  46. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Review Articles
  128. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  129. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  130. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  131. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  132. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  133. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  134. The application of augmented reality in robotic general surgery: A mini-review
  135. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  136. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  137. Plant polyphenols, terpenes, and terpenoids in oral health
  138. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  139. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  140. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  141. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  142. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  143. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  144. Giant borderline ovarian tumours – review of the literature
  145. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  146. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  147. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  148. Supplement strategies for infertility in overweight women: Evidence and legal insights
  149. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  150. Case Reports
  151. Delayed graft function after renal transplantation
  152. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  153. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  154. Giant right atrial hemangioma presenting with ascites: A case report
  155. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  156. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  157. Rapid Communication
  158. Biological properties of valve materials using RGD and EC
  159. Letter to the Editor
  160. Role of enhanced external counterpulsation in long COVID
  161. Expression of Concern
  162. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  163. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  164. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  165. Corrigendum
  166. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  167. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  168. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  169. Retraction
  170. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  171. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  172. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  173. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  174. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  175. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  176. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  177. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  178. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  179. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  180. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  181. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  182. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  183. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  184. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  185. Special Issue Diabetes
  186. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  187. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  188. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  189. A review of brain research on T2DM-related cognitive dysfunction
  190. Special Issue Biomarker Discovery and Precision Medicine
  191. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
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