Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
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Bifulco Maurizio
,
Di Zazzo Erika
,
Pagano Cristina
Abstract
Background and objective
The World Health Organization (WHO) appeal of January 15, 2024, stated “The current number, size and concurrence of multiple outbreaks, the spread to areas free of cholera for decades and alarmingly high mortality rates present a major threat to global health security.” The current state is extremely worrying, considering the difficulties of countries in dealing with cholera epidemics due to the lack of funding and the difficulty in oral cholera vaccine production and administration. This study aims to analyse the past and current influence of anthropization on cholera onset.
Methods
We analysed the literature, particularly of the last 5 years, on the influence of human actions that impact the spread of cholera.
Results
The epidemiological data published by WHO and the available literature highlight a strong impact of human actions on the epidemic spread of cholera, the government’s difficulty in making decisions on epidemic prevention or containment, and the fear of the population.
Conclusions
Cholera should be considered an anthropogenic disaster, considering the historical health analysis of the cholera epidemics in Italy in the last two centuries and in southern Italy and in Naples in 1973.
1 Overview of the current situation of cholera epidemics
The year 2024 opened with an alarming appeal from the World Health Organization (WHO) regarding cholera: “The current number, size and concurrence of multiple outbreaks that have spread to areas free of Cholera and the alarmingly high mortality rates present a major threat to global health security” [1].
A wave of cholera epidemics without precedent occurred in the 2-year period of 2022–2023, even in countries that have not reported cholera for many years [2].
The data, not definitive, relating to 2023 and updated to December 15th, recorded 667,000 cholera cases and over 4,000 deaths. These numbers are extremely worrying, especially when compared to those of past years, which in turn are increasing compared to previous periods [3]. In 2022, the global number of cholera cases reported to WHO was 472,697, compared to 223,370 cases in 2021 [4].
The WHO African Region remains the most affected region worldwide, with 17 countries reporting cholera cases throughout 2023.
The current ability to deal with cholera epidemics is severely limited by the lack of funding at a global level due to the enormous expenses faced by the COVID-19 pandemic. In addition, there are several difficulties related to the production and distribution of oral vaccines against cholera.
This places a huge burden on vaccine manufacturing as the large requests means that the supplies dedicated to preventive campaigns are limited. In 2013, 12 countries submitted requests for significant supplies of anti-cholera vaccines because they were affected by very virulent cholera epidemics. “A total of 33 million doses were dispatched, fully allocating the available stockpile. […] In December alone, four new requests, totalling 13.6 million doses, were submitted to the International Coordinating Group (ICG) from Ethiopia, Sudan, Zambia, and Zimbabwe. […] As of 9 January 2024, the global OCV stockpile stands at 1.1 million doses, which are available for allocation but not yet committed” [5].
2 Cholera epidemics between the nineteenth and twentieth centuries: Fear and lack of knowledge of the causes
Endemic in Asia, and mainly in the delta of the Ganges (India), it remained narrowed to that geographical area until the beginning of the 1800s. It first emerged from the Sundarbans Forest of the Bay of Bengal, in the Ganges delta, where the bacterium Vibrio cholerae had probably been mutating for millennia. The microorganism is found naturally in the environment in some coastal areas, wastewater, and brackish waters, where shellfish often carry the infection. It subsequently reached the Mediterranean and Europe as new trade routes were opened between the East and West [2].
Cholera is an acute enteric infection caused by the bacterium V. cholerae, belonging to the genus Vibrio, of the family Vibrionaceae. The genus Vibrio includes pathogens to humans (V. cholerae, Vibrio parahaemolyticus, Vibrio vulnificus), opportunistic pathogenic species (Vibrio alginolyticus, Vibrio mimicus, etc.) and other saprophytic isolates from the sweet waters of the sea (Vibrio anguillarum, Vibrio fischeri, etc.), which can be confused with human vibrios [6].
The V. cholerae was observed for the first time under microscope in 1854 by the Italian anatomist Filippo Pacini (1812–1883) in Florence. In 1884, it was isolated in Egypt and studied in detail by the German physician Robert Koch (1843–1910) [7].
During the nineteenth and twentieth centuries, the disease spread globally beyond Asia seven times, referred to as the cholera pandemics. The first cholera pandemic started in August 1817 when the British government received a report of a “malignant disorder” in the Sundarbans, killing 20–30 people a day, and during the following weeks, 10,000 people died. Thereafter, the disease spread across the countries reaching eastwards and westwards of Nepal, Iran, Iraq, Afghanistan, Oman, Thailand, Burma, China, and Japan. The incidence of cholera decreased, but a second one began in 1826, and the source was again the Ganges Delta, and the disease spread fast again, but also moving towards the United States, Europe, and Egypt. Cairo and Alexandria recorded 33,000 deaths a day.
Subsequently, new pandemics began in 1829, 1831 (when it devastated the great trading city of Astrakhan), 1852, 1863, 1881, 1889, and 1961 [8], the last persisting until now [9,10].
Cholera appeared in Europe in the first half of the ninetenth century, because of the opening of new communication routes between the East and West: its journey began in India in 1817, in a very difficult period for the Indian subcontinent, which was hit by floods and continuous famines. The large masses of people who, on this occasion, began to move from the areas affected by famine caused the disruption of an environmental balance, which determined the spread of the cholera bacterium outside its natural habitat. This difficult situation was certainly exacerbated by the appearance of a more virulent variant of the disease, which inexorably affected that large mass of fugitives who hoped to leave hunger behind and, instead, increasingly malnourished and in precarious hygienic-sanitary conditions, ended up a victim of the first cholera pandemic (1817–1823).
However, it was the second pandemic that originated in the 1820s that fully affected Europe, causing massacres among the poorest and most defenseless population [11].
When cholera first appeared in Europe, at the end of the 1820s, the advanced world began with great concern to acknowledge. Physicians in France, Britain, and Russia began studying the disease as a matter of urgency. It progressively followed the trade route and appeared in new places only after the arrival of people from the infected area.
The cholera origin from distant and unknown countries, the spreading speed and the sudden death of infected people had a very strong impact on collective imagination, fueling anxiety and terror, similarly to COVID-19 pandemic [12].
In 1836, cholera reached the south of the Italian peninsula. It hit Naples, the capital of the Kingdom of the Two Sicilies, with great force, in two successive phases: between October 1836 and March 1837 and then from April 1837 to October 1837. In the first phase, it infected 10,361 people, of which 5,669 (54.7%) died. Much more serious was the second epidemic in which 21,784 people were infected and 13,810 died, with a lethality rate of 69.39% [13].
In Italy, cholera struck with great force between 1884 and 1886, arriving from France and, in particular, from the port city of Toulon, where a ship from Indochina had landed carrying soldiers suffering from an anomalous form of gastroenteritis, probably identified as cholera.
To prevent the spread of cholera in the various italian regions, it was decided to prohibit access to the ports for ships coming from Toulon and the infected areas. The first case was recorded in Piedmont; the infection then spread to Liguria, Lombardy, Tuscany, and Veneto, and in August, it reached Naples and then Calabria, invading all of Southern Italy. Naples was certainly its epicenter: the frequent and constant commercial relations with the French ports, the living conditions of a large part of the population who lived in the port area, the inadequate sewage system, the poor supply of drinking water, as well as the disorganization of the hospitals were the main causes of the devastation of Naples and the surrounding areas.
Consider that, in 1884, the conditions of the Neapolitan water network were truly terrible: the water, undrinkable and polluted, arrived from two aqueducts: the Bolla and the Carmignano (the most recent dated back to 1627), which had not received any expansion or maintenance work. In the homes, especially those in the lower city (which housed around 130,000 people in difficult hygienic conditions), there was no type of sewage system, and the only outlets were the stairs and courtyards of the homes, and everything was poured out along the roads.
To avoid the continuation of the epidemic and any new epidemics, the “gutting” of the ancient part of Naples was ordered, with the demolition of the degraded neighbourhoods and the construction of new ones [14].
It is estimated that this cholera epidemic caused in the Neapolitan area around 8,000 victims, two-thirds of the deaths that affected the whole of Italy on that occasion [15].
The disease returned to hit the regions of Southern Italy, especially in Puglia, Sicily, and Campania, between 1910 and 1911, fortunately causing fewer deaths. On both occasions, cholera spread due to the poor hygienic conditions of the affected cities. The same causes can be remembered for the epidemics of the 1910s. The government of the time commissioned the hygienist Achille Sclavo (1861–1930) to coordinate all actions to eradicate or at least limit the spread of cholera, which had hit Southern Italy, particularly in Puglia and Sicily [16,17]. During that period (on that occasion), Sclavo published the writing on the problem of sewage in Puglia with special attention to the biological purification of sewer water [18].
For reasons that are not easily identifiable, probably linked to the serious droughts that hit many African regions in the summer of 1973, unfortunately the spread of cholera was recorded in some African countries on the Mediterranean coast, especially in Tunisia and Algeria; immediately afterwards, reports of isolated imported cases with local spread began in various European countries such as England, France, Sweden, and Germany with 25 cases. Beginning on August 26, cholera also affected Italy with 277 bacteriologically verified cases (period August-October 1973), mainly in Campania (130 cases and 15 deaths) and Puglia (125 cases and 7 deaths) [19]. Cholera was again recorded with a high percentage in the city of Naples.
Exactly 30 years ago, in 1994, the first cases of cholera were recorded in the city of Bari. The latest cases reported in Italy were recorded in 2019 [20] (one case) and in 2023 (one case).
In both cases, although there were bacteria in the patients’ feces, V. cholerae, these were not the strains responsible for the disease.
The transmission of the bacterium and, consequently, of the disease is closely linked to the impossibility of accessing clean water, the consumption of contaminated food, and in general, poor hygienic-sanitary conditions and the poor management of sewage systems and drinking water. This is evident in all those places where, due to a lack of treatment and prevention or due to wars or earthquakes that destroy plants and infrastructures, preventing access to clean water, cholera forcefully returns to infect populations, often already suffering from hunger and other diseases.
3 Cholera in Naples in 1973
Fifty years have passed since the epidemics of cholera, which, between August and November 1973, hit Naples [21].
The epidemic aroused disbelief and fear, although the number of cases was limited. It was not possible to understand how such a disease could affect an industrialized country like Italy. At the same time, the memory of past epidemics of cholera caused great concern among the population.
On August 29, 1973, the Neapolitan newspaper “Il Mattino” announced the epidemic, that caused seven deaths (five in Torre del Greco and two in Naples) and hospitalization of over fifty infected people. To limit the spread, authorities banned the consumption of raw fish and shellfish, which was the likely soure of cholera.
Although the episode is roughly referred to only as the city of Naples, it was a social, political, and economic phenomenon, which had significant consequences throughout the national territory. In particular, the pandemic affected the coastal regions of Campania and Puglia and the province of Cagliari in Sardinia in 1973 [22], and dozens of cases were also recorded in Rome, Milan, Florence, and Bologna. “The epidemic became a national threat.” The emergency even extended to the peripheral area of Rome (plagued in its own way by hygienic-social problems not dissimilar to the capital of Campania), just as threats of contagion were recorded in several parts of the country [23].
Thanks to an extraordinary vaccination campaign, the epidemic was contained within a few weeks. Official data reported 277 infected and 24 deaths, mostly concentrated in Naples, due to the consequences of infection with V. cholerae type 1 “The Tor.” It was ascertained that the strain responsible for the epidemic was widespread in muddy marine waters, contaminated by V. cholerae due to the inadequacy of the sewage system (whose last modernization dated back to the years of the restoration following the tragic epidemic of cholera that occurred between 1884 and 1887), along with spills of industrial processing waste. The sewerage system was divided into an impressive number of uncovered collection channels and dozens of discharges (authorized and illegal), which were released directly into the sea, the sewage produced by a city which, in just under 20 years, had doubled its population and its territorial extension [23]. Yet, in August 1973, many people on the coast of Naples challenged the absolute ban on bathing, diving into the sea.
The Health Care System was absolutely unprepared to deal with the epidemic at the time, so much so that the reports published by “The Times” and “Le Monde” described the confusion, improvisation, and approximation that characterized the Cotugno hospital in Naples during the emergency epidemic [23]. Within a short time, fear took possession of the Neapolitan citizens and the whole of Italy due to a pressing yet approximate narrative of the Media.
Thanks to the mass vaccination campaign, which was organized in a short time and began on September 1, 1973, it was possible to contain the number of infected people and, above all, the number of victims. The strategy of spreading vaccination extensively and across the entire population was, without a doubt, one of the most effective and successful interventions, as history had already taught us [24,25,26]. They were vaccinated in pharmacies, in the sports hall, and in the political party sections. Important support also came from NATO healthcare personnel: U.S. servicemen from the Environmental Preventive Medicine Unit (EPMU) No. 7 of the Sixth Fleet, present in Naples, vaccinated the population using the pistol syringes already used for mass vaccinations during the Vietnam War [27].
Despite the disorganization, also denounced by protests from citizens (Figure 1), as of September 5, 1973, one million two hundred thousand people had already been vaccinated and despite the difficulties dictated by the complex contingency, the confusion created and the emergency, it was possible to set up effective and immediate communication without particular resistance in terms of uncertainty and vaccination hesitancy on the part of the entire population [28,29,30].
Protests in Naples in 1973 due to the lack of vaccines (public domain image).
The vaccination was also accompanied by specific hygiene actions, such as the extraordinary disinfection of the city’s streets with 1,500 tons of disinfectant (Figure 2), and the temporary closure of social places. In Naples, the last case was recorded on September 19, 1973, and the epidemic could be considered over on 12 October of the same year.
Disinfestation of the streets of Naples during the cholera epidemic of 1973 (public domain image).
4 Similarities and differences between past and present: Research objective and methodology
Through the analysis and comparison of cholera epidemics of the nineteenth and twentieth centuries, the article aims to analyse past and current influences of human actions in favouring the onset of cholera epidemics.
Considering the recent outbreak of cholera epidemics in many countries, we performed a narrative review by analysing WHO reports and current available scientific literature of the last 5 years. Particularly, we investigated the impact of human activities, both direct as the wars ongoing in different regions of the world where cholera is dangerously reappearing, both indirect as famines, droughts, floods due to major climate changes attributable to anthropization, on cholera epidemic spreading. The search was performed in the PubMed-Medline in February 2024.
5 Worrying results: Cholera, a disease of iniquity, is a consequence of humanity’s wrong action
“Cholera is an ancient disease that remains a public health problem in many impoverished locations around the world. Overcrowding, poverty, insufficient water and sanitation facilities increase the risk for Cholera outbreaks” [10].
During the nineteenth-century epidemics, that of Naples in 1973, and the epidemics that have been affecting many areas of the Earth in recent years, the spread of cholera can be traced back to wrong actions carried out by man.
Therefore, one of the findings of this study is that cholera is not a natural catastrophe but must be considered in most cases an anthropic disaster. The epidemic in Naples in 1973 dramatically brought out a complex set of submerged but characterizing elements of the economic, social, and hygienic-health conditions of Naples as well as most of Southern Italy. Naples was, in those years, a metropolis in which heterogeneous social strata coexisted, marked by profound inequalities, a city in which the presence of gastrointestinal diseases, such as typhoid and viral hepatitis, was endemic in a population that lived in an urban space among the most overcrowded in the world. Similarly, many of the cholera epidemics in recent years are affecting poor populations living in complex socio-economic situations, who are often affected by famine, war or environmental disasters.
“Cholera remains a disease of inequity, disproportionately affecting the world’s poorest and most vulnerable populations” [1].
In addition, cholera epidemics are also facilitated by climate change, which, albeit indirectly, is attributable to the actions of contemporary society [31].
Considering the inability of the governments of various countries to counteract the worsening of climate changes, the increasing migration rate, and the worsening of living conditions also due to the lack of access to clean water, cholera epidemics will further spread.
Recent studies have linked the increase in sea water temperatures and cholera epidemics. Vibrios are in fact bacteria that prefer warm marine waters. Their global increase is provoked by marine warming.
“Climate change is a major driver of infectious disease dynamics through changes in temperature and precipitation. The effect of climate change on infectious diseases disproportionately affects low- and middle-income countries (LMIC)” [32,33].
Many researchers are warning of the impact that climate change sensitive to greenhouse gases (GHGs) may have on the emergence and re-emergence of infectious diseases [34]. A recent study has established that “58% (that is, 218 out of 375) of infectious diseases confronted by humanity worldwide have been at some point aggravated by climatic hazards; 16% were at times diminished. […] The human pathogenic diseases and transmission pathways aggravated by climatic hazards are too numerous for comprehensive societal adaptations, highlighting the urgent need to work at the source of the problem: reducing GHG emissions” [35].
6 Conclusions
Based on the results of our analysis of WHO reports and currently available scientific literature regarding cholera epidemics, it is possible to conclude that climate change, rapid urbanization, wars, and above all, the changing patterns of use of large spaces on our planet will increase the risk of disease outbreaks in the coming decades. In particular, climate change may alter the range of pathogens, allowing infections, particularly vector-borne infections, to expand into new locations. A new era is therefore opening for infectious diseases.
Through the memory of the last great epidemic that hit Italy, we believe that it is current and necessary to re-propose the theme of cholera prevention in a historical moment in which this disease is returning to affect increasingly larger areas of the Earth.
Similarly, to the cholera epidemic of Naples in 1973, the disease retains specific elements attributable to the lack of hygiene and water contamination. However, to this, there are equally, if not more dangerous, contributory causes linked to environmental problems and more generally to anthropization.
The effects of climate change, caused by the set of transformation and alteration interventions that humans are carrying out at the expense of the Earth to bend it to his own interests, also have important repercussions on human health and on public health as a whole [36].
“Climate change can alter environmental temperature, wind, and precipitation patterns, which can indirectly affect pathogen distribution, vector reproduction rates, and transmission media. These effects then further determine regional shifts in seasonal patterns of individual diseases along with its respective frequency and severity” [37].
While global warming has proven harmful to some pathogens, climate change is largely increasing the risk of infectious diseases. Added to this is the possibility that pathogens may become increasingly resistant to heat, becoming extremely dangerous for humans as they will be able to survive one of our body’s main defense mechanisms: fever.
On the basis of these observations, it is necessary to interrupt – as far as is within man’s possibilities – this chain of disastrous events for the planet and for human health. The awareness that the survival of humanity is inseparably connected to that of the planet must push humanity and governments to adopt radically different lifestyles and sustainable consumption models to slow down and keep under control those climate changes that can lead to an increase in the spread of pathogens and their resistance to our natural defenses and drugs.
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Funding information: This research received no external funding.
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Author contributions: Conceptualization: M.B., D.O., and M.M.; investigation: M.B., D.O., M.M., C.P., and E.D.Z.; writing – original draft preparation: M.B., D.O., M.M., C.P., and E.D.Z.; writing – review and editing: M.B., D.O., and M.M.; and supervision: M.B., D.O., and M.M. All authors have read and agreed to the published version of the article.
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Conflict of interest: The authors state no conflict of interest.
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Data availability statement: Not applicable.
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- Risk factors for severe adverse drug reactions in hospitalized patients
- Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
- Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
- CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
- Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
- Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
- Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
- Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
- Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
- Association between statin administration and outcome in patients with sepsis: A retrospective study
- Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
- A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
- Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
- Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
- Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
- Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
- Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
- The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
- Health literacy and health-related quality of life: The mediating role of irrational happiness
- Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
- Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
- Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
- Clinical analysis of ten cases of HIV infection combined with acute leukemia
- Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
- Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
- Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
- Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
- Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
- The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
- The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
- Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
- Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
- Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
- The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
- Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
- A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
- A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
- Identifying early screening factors for depression in middle-aged and older adults: A cohort study
- Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
- Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
- High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
- RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
- Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
- Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
- The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
- Expression and clinical significance of ITGA3 in breast cancer
- Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
- rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
- Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
- Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
- Gender beliefs and legitimization of dating violence in adolescents
- Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
- Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
- Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
- Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
- Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
- Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
- GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
- Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
- MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
- Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
- Trends in research on preterm birth in twin pregnancy based on bibliometrics
- Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
- Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
- Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
- Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
- Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
- CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
- Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
- Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
- Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
- Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
- Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
- Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
- Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
- The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
- The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
- Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
- Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
- The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
- Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
- Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
- Correlation of serum calprotectin with outcome of acute cerebral infarction
- Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
- Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
- The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
- Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
- Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
- Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
- Analysis of serum metabolomics in patients with different types of chronic heart failure
- Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
- Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
- Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
- METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
- The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
- Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
- Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
- Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
- Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
- Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
- Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
- Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
- Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
- Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
- Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
- Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
- HALP score in Demodex blepharitis: A case–control study
- Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
- Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
- Comparison of the two intestinal anastomosis methods in pediatric patients
- Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
- Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
- Review Articles
- The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
- Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
- Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
- Review of mechanisms and frontier applications in IL-17A-induced hypertension
- Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
- The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
- The application of augmented reality in robotic general surgery: A mini-review
- The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
- Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
- Plant polyphenols, terpenes, and terpenoids in oral health
- Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
- End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
- The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
- Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
- PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
- Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
- Giant borderline ovarian tumours – review of the literature
- Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
- Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
- Case Reports
- Delayed graft function after renal transplantation
- Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
- Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
- Giant right atrial hemangioma presenting with ascites: A case report
- Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
- Rapid Communication
- Biological properties of valve materials using RGD and EC
- Letter to the Editor
- Role of enhanced external counterpulsation in long COVID
- Expression of Concern
- Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
- Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
- Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
- Corrigendum
- Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
- Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
- Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
- Retraction
- Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
- Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
- Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
- Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
- The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
- Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
- Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
- Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
- Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
- Special Issue The evolving saga of RNAs from bench to bedside - Part III
- Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
- Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
- Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
- A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
- Special Issue Diabetes
- Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
- Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
- Special Issue Biomarker Discovery and Precision Medicine
- CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
Artikel in diesem Heft
- Research Articles
- Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
- Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
- Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
- Risk factors for severe adverse drug reactions in hospitalized patients
- Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
- Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
- CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
- Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
- Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
- Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
- Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
- Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
- Association between statin administration and outcome in patients with sepsis: A retrospective study
- Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
- A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
- Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
- Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
- Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
- Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
- Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
- The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
- Health literacy and health-related quality of life: The mediating role of irrational happiness
- Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
- Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
- Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
- Clinical analysis of ten cases of HIV infection combined with acute leukemia
- Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
- Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
- Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
- Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
- Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
- The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
- The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
- Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
- Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
- Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
- The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
- Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
- A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
- A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
- Identifying early screening factors for depression in middle-aged and older adults: A cohort study
- Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
- Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
- High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
- RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
- Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
- Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
- The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
- Expression and clinical significance of ITGA3 in breast cancer
- Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
- rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
- Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
- Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
- Gender beliefs and legitimization of dating violence in adolescents
- Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
- Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
- Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
- Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
- Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
- Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
- GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
- Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
- MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
- Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
- Trends in research on preterm birth in twin pregnancy based on bibliometrics
- Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
- Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
- Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
- Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
- Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
- CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
- Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
- Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
- Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
- Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
- Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
- Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
- Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
- The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
- The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
- Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
- Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
- The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
- Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
- Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
- Correlation of serum calprotectin with outcome of acute cerebral infarction
- Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
- Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
- The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
- Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
- Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
- Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
- Analysis of serum metabolomics in patients with different types of chronic heart failure
- Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
- Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
- Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
- METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
- The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
- Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
- Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
- Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
- Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
- Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
- Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
- Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
- Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
- Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
- Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
- Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
- HALP score in Demodex blepharitis: A case–control study
- Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
- Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
- Comparison of the two intestinal anastomosis methods in pediatric patients
- Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
- Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
- Review Articles
- The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
- Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
- Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
- Review of mechanisms and frontier applications in IL-17A-induced hypertension
- Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
- The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
- The application of augmented reality in robotic general surgery: A mini-review
- The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
- Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
- Plant polyphenols, terpenes, and terpenoids in oral health
- Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
- End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
- The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
- Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
- PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
- Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
- Giant borderline ovarian tumours – review of the literature
- Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
- Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
- Case Reports
- Delayed graft function after renal transplantation
- Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
- Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
- Giant right atrial hemangioma presenting with ascites: A case report
- Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
- Rapid Communication
- Biological properties of valve materials using RGD and EC
- Letter to the Editor
- Role of enhanced external counterpulsation in long COVID
- Expression of Concern
- Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
- Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
- Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
- Corrigendum
- Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
- Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
- Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
- Retraction
- Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
- Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
- Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
- Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
- The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
- Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
- Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
- Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
- Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
- Special Issue The evolving saga of RNAs from bench to bedside - Part III
- Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
- Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
- Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
- A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
- Special Issue Diabetes
- Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
- Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
- Special Issue Biomarker Discovery and Precision Medicine
- CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
