Trends in research on preterm birth in twin pregnancy based on bibliometrics
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Biaobiao Wang
Abstract
Background
Twin pregnancies are associated with a higher risk of perinatal mortality compared to singleton pregnancies. This study evaluated the developmental trends and summarized the key features of research on preterm births in twin pregnancies.
Methods
A bibliometric analysis was conducted using publications on preterm births in twin pregnancies from 2014 to 2023, retrieved from the Web of Science Core Collection database. Network and visual analyses were performed using VOSviewer and CiteSpace software. In total, 1,378 articles were included.
Results
The number of publications in this field has shown a steady increase over the past decade. The United States, China, and England collectively contributed more than half of all publications. King’s College London, Columbia University, and Jefferson University were identified as the most influential institutions, fostering extensive collaboration and academic exchange. Am J Obstet Gynecol emerged as the most cited journal. Research has predominantly focused on clinical practices, including prevention strategies, risk factor identification, and perinatal outcomes.
Conclusion
This bibliometric analysis offers a comprehensive overview of research trends on preterm births in twin pregnancies, highlighting major contributors, influential institutions, and primary research foci. The findings provide valuable insights for researchers, aiding the identification of future research directions in this critical field.
1 Introduction
The incidence of twin pregnancies has increased in recent years, largely due to the growing use of assisted reproductive technology (ART) and the increasing maternal age at conception. ART is associated with a higher likelihood of twin or triplet pregnancies, and advanced maternal age is also related to an increased probability of multiple pregnancies [1]. In addition, older maternal age, often accompanied by ovarian and uterine aging, can result in poor reproductive performance, necessitating the use of ART [2]. Twin pregnancies are associated with an elevated risk of pregnancy complications, including preterm birth, preeclampsia, intrauterine growth restriction, and other adverse outcomes [3].
Monochorionic twin pregnancies, which involve a shared placenta, carry an even higher risk of complications, such as twin-to-twin transfusion syndrome and twin anemia-polycythemia sequence [4]. Furthermore, compared to singletons, neonates from twin pregnancies face an increased risk of adverse outcomes, including congenital anomalies, cerebral palsy, intrauterine growth restriction, and stillbirth [5]. Although twin pregnancies account for only about 3% of all live births, they represent up to 15% of admissions to special care units [6,7].
Twin pregnancies are also associated with a higher risk of perinatal mortality, predominantly due to preterm birth [8]. The preterm birth rate in twin pregnancies has significantly increased over the past three decades, paralleling the global increase in twin birth rates. While 8.76% of women with singleton pregnancies deliver before 37 weeks of gestation and 2.20% before 34 weeks, the corresponding rates for twin pregnancies are markedly higher, being 62.05 and 20.28%, respectively [7].
Given these heightened risks, it is essential to summarize the characteristics and research topics related to preterm birth in twin pregnancies. Bibliometric analysis is a valuable statistical tool for analyzing published literature and constructing relationship maps, providing insights into development trends and research hotspots [9].
In this study, we conducted a bibliometric analysis of the current trends in preterm birth among twin pregnancies. We identified and analyzed documents published over the past decade, focusing on the number of publications per year, contributing authors, affiliated countries, journals, institutions, references, and keywords. Our results provide a comprehensive overview of the current state of research, highlight development trends, identify research hotspots, and outline potential directions for future studies.
2 Methods
2.1 Data source and search strategy
The Web of Science Core Collection, a leading citation database of scientific publications, including scholarly journals and citation index information, served as the primary data source. The search strategy is illustrated in Figure 1. In total, 2,231 records were initially identified in the database. After applying restrictions to include only English language publications between January 1, 2014, and December 1, 2023, 1,483 records remained. Subsequently, 105 records, including meeting abstracts (50), editorial materials (35), letters (18), corrections (1), and retracted publications (1), were excluded, resulting in 1,378 documents that were exported for analysis.
PRISMA flow diagram of the identification of studies via the database.
2.2 Data analysis
Following the data search, information on publication years, affiliated countries, institutions, authors, journals, and references was collected for further analysis and discussion [10]. CiteSpace and VOSviewer were utilized as the primary tools for bibliometric analysis. CiteSpace was used for cocitation analysis and citation burst detection, while VOSviewer was used for network visualization and cluster analyses, including coauthorship analysis, journal citations, reference citations, and keyword cooccurrence analysis [11].
Each node in the distribution map represented a country, institution, author, journal, or reference. In CiteSpace, a purple ring around a node indicated centrality, signifying the occurrence of a pivotal node within the field and its substantial influence. Centrality acted as a hinge point, with nodes representing countries or institutions with higher centrality if they were linked to multiple other nodes. Lines between nodes represent cooperative relationships, with the thickness of the lines denoting the strength of collaboration [10]. The annual and cumulative publications of institutions were visualized using bar charts.
3 Results
3.1 Annual publications on preterm birth in twin pregnancies
The number of publications reflects trends over time, representing public interest in a specific field. Figure 2 illustrates the annual distribution of publications on preterm births in twin pregnancies from 2014 to 2023. Over the past decade, the number of publications has exhibited a steady upward trend, peaking at 180 papers in 2020. However, a slight decline was observed from 2021 to 2023, likely attributable to time restrictions in data collection, as some 2023 publications were not included. Overall, the growth in publication numbers highlighted increasing attention to preterm births in twin pregnancies.
Annual publications on preterm births in twin pregnancies.
3.2 Geographical distribution of published countries
In all, 93 countries contributed to research in this field. The top 10 were the USA, China, England, Australia, Italy, Canada, France, Israel, Spain, and the Netherlands. The USA, China, and England collectively accounted for more than half of all publications. Detailed percentages of publications from the top 10 countries are presented in Figure 3.
Top ten countries by number of publications.
Using CiteSpace, we visualized the geographical distribution and cooperative networks among countries (Figure 4). The blue and yellow color ring represents the proportional articles published in a certain year. The purple ring outside the yellow ring represents the centrality which indicates the influence and importance of the research. Countries with the highest number of publications such as the USA, and China are labeled with purple rings, indicating that these countries maintain high research interest in this field and play an important role in the development of research of the preterm birth in twin pregnancy. Interestingly, although Finland and Italy were not among the top ten countries by publication count, they ranked in the top five for centrality, demonstrating that research impact is not solely determined by the number of publications.
Coauthorship among countries with at least 15 publications. Nodes represent countries, with blue and purple rings indicating publication counts and centrality, respectively.
3.3 Institutional coauthorship
In total, 2,046 institutions published papers related to preterm births in twin pregnancies. The top ten institutions contributing the most publications are shown in Figure 5. Among these, the University of London, the University of Toronto, and the Université Paris Cité led by a significant margin. Rankings based on centrality are presented in Table 1, showing King’s College London, Columbia University, and Jefferson University as the top three central institutions in this field.
Top ten institutions by publication count.
Top ten institutions ranked by centrality in studies on preterm births in twin pregnancies
| Rank | Centrality | Institute |
|---|---|---|
| 1 | 0.64 | King’s College London |
| 2 | 0.42 | Columbia University |
| 3 | 0.40 | Jefferson University |
| 4 | 0.39 | Catholic University of the Sacred Heart |
| 5 | 0.39 | University of London |
| 6 | 0.34 | Guy’s & St Thomas’ NHS Foundation Trust |
| 7 | 0.32 | Icahn School of Medicine at Mount Sinai |
| 8 | 0.25 | King’s College Hospital NHS Foundation Trust |
| 9 | 0.25 | King’s College Hospital |
| 10 | 0.25 | Michigan State University |
A coauthorship visual analysis was performed, setting the minimum publication threshold per institution to 20. Active collaborations were observed among institutions worldwide (Figure 6). King’s College London demonstrated the highest centrality, maintaining strong connections with 11 other institutions, including the University of London, the University of Bristol, and Guy’s and St Thomas’ NHS Foundation Trust.
Collaboration network among institutions. Nodes represent institutions, with blue and purple rings denoting publication counts and centrality, respectively.
3.4 Analysis of coauthorship and cocitation
The 1,378 documents analyzed included contributions from 7,087 authors, of whom 146 had authored at least 5 papers. The results of coauthorship analysis conducted using VOSviewer is shown in Figure 7a. This analysis organized 129 authors into 14 clusters, each represented by a distinct color corresponding to a research team. The top ten most prolific authors, with no fewer than ten publications, are listed in Table 2.
Visualization of coauthorship and cocitation analyses. (a) Coauthorship of 146 authors with at least 5 publications, represented in 14 clusters. (b) Cocitation analysis of 309 authors cited at least 20 times, categorized into 5 clusters.
Top ten authors ranked by publication and cocitation counts
| Rank | Author | Publications | Co-cited author | Co-citations |
|---|---|---|---|---|
| 1 | Fox, NS. | 28 | Romero, R. | 457 |
| 2 | Melamed, N. | 26 | Berghella, V. | 369 |
| 3 | Barrett, J. | 23 | Conde-Agudelo, A. | 276 |
| 4 | Khalil, A. | 22 | Goldenberg, RL. | 275 |
| 5 | Rebarber, A. | 19 | Luke, B. | 250 |
| 6 | Berghella, V. | 17 | Martin, JA. | 247 |
| 7 | Romero, R. | 13 | Fox, NS. | 246 |
| 8 | Saccone, G. | 13 | Saccone, G. | 201 |
| 9 | Mol, Ben W. | 13 | Pinborg, A. | 176 |
| 10 | Saltzman, DH. | 13 | Lewi, L. | 155 |
Cocitation analysis was used to evaluate instances where authors, journals, or references of two or more papers were cited by the same article. The top ten authors based on cocitation counts are also presented in Table 2. For visualization, 309 authors cocited at least 20 times were selected. Five clusters were identified, with the largest including 94 authors, followed by clusters of 85, 65, 62, and 3 authors (Figure 7b).
3.5 Top ten cited and cocited journals
The 1,378 publications were distributed across 349 journals. Table 3 lists the top ten cited and cocited journals in this field. The American Journal of Obstetrics and Gynecology ranked first with 2,454 citations, followed by Ultrasound in Obstetrics and Gynecology (1,483 citations) and Fertility and Sterility (655 citations).
Top ten cited and cocited journals in studies on preterm births in twin pregnancies
| Rank | Journal | Counts | Co-cited journal | Counts |
|---|---|---|---|---|
| 1 | Am J Obstet Gynecol | 2,454 | Am J Obstet Gynecol | 6,299 |
| 2 | Ultrasound Obstet Gynecol | 1,483 | Obstet Gynecol | 3,092 |
| 3 | Fertil Steril | 1,010 | Ultrasound Obstet Gynecol | 2,709 |
| 4 | Hum Reprod | 891 | Hum Reprod | 1,676 |
| 5 | J Matern Fetal Neonatal Med | 867 | Fertil Steril | 1,617 |
| 6 | Obstet Gynecol | 708 | BJOG: an international journal of obstetrics and gynecology | 1,407 |
| 7 | BJOG: an international journal of obstetrics and gynecology | 607 | J Matern Fetal Neonatal Med | 1,374 |
| 8 | PLoS One | 591 | Lancet | 1,169 |
| 9 | MMWR Surveillance Summaries | 530 | N Engl J Med | 974 |
| 10 | Eur J Obstet Gynecol Reprod Biol | 487 | Eur J Obstet Gynecol Reprod Biol | 834 |
Cocitation analysis was performed on 217 journals with at least 20 citations, generating a network map divided into 7 clusters (Figure 8). The top three cocited journals were the American Journal of Obstetrics and Gynecology (6,299 cocitations), Obstetrics and Gynecology (3,092), and Ultrasound in Obstetrics and Gynecology (2,709).
Cocitation map of journals with a threshold of 20 citations, divided into 7 clusters by color.
3.6 Highly cited and cocited references
The frequency of citations reflects the influence and interest of an article within the research community. In all, 167 cocited references were included in the VOSviewer analysis. Figure 9 illustrates the top 20 references with the strongest citation bursts by year. The reference with the strongest citation burst, published in 2012, was titled “Vaginal progesterone in women with an asymptomatic sonographic short cervix in the mid-trimester decreased preterm delivery and neonatal morbidity: A systematic review and meta-analysis of individual patient data.” The second highest, published in 2013, was “Cervical pessaries for the prevention of preterm birth in women with multiple pregnancies.”
Top 20 references with the strongest citation bursts by year.
Four clusters of cocitation analysis were identified using VOSviewer (Figure 10). Larger nodes in the visualization represent references with higher cocitation frequencies. The clusters, differentiated by colors, represent 78 (red), 35 (green), 29 (blue), and 25 (yellow) references, respectively. The top ten cited references are listed in Table 4. The most frequently cited paper, “Cohort Profile Update: The Norwegian Mother and Child Cohort Study,” published in the International Journal of Epidemiology in 2016, was cited 505 times. The second, titled “ISUOG Practice Guidelines: The role of ultrasound in twin pregnancy,” had 314 citations. The third, “Coronavirus in pregnancy and delivery: rapid review,” explored the impact of coronavirus on pregnancy and delivery. Notably, two of the top ten references were published in the American Journal of Obstetrics and Gynecology.
Cocitation map of references, where nodes represent individual references, and colors indicate clusters.
Top ten cited papers on preterm births in twin pregnancies
| Rank | Title | First author | Cited frequency | Journal | Year |
|---|---|---|---|---|---|
| 1 | Cohort profile update: the Norwegian mother and child cohort study (MoBa) | Magnus, P. | 505 | Int J Epidemiol | 2016 |
| 2 | ISUOG Practice Guidelines: role of ultrasound in twin pregnancy | Khalil, A. | 314 | Ultrasound Obstet Gynecol | 2016 |
| 3 | Coronavirus in pregnancy and delivery: rapid review | Mullins, E. | 274 | Ultrasound Obstet Gynecol | 2020 |
| 4 | Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data | Roberto, R. | 262 | Am J Obstet Gynecol | 2018 |
| 5 | Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors | Warrington, NM. | 261 | Nat Genet | 2019 |
| 6 | The risk factors for postpartum depression: A population-based study | Silverman, ME. | 211 | Depress Anxiety | 2017 |
| 7 | Systematic review of worldwide trends in ART 2004–2013 | Kushnir, VA. | 190 | Reprod Biol Endocrinol | 2017 |
| 8 | The role of routine cervical length screening in selected high- and low-risk women for preterm birth prevention | McIntosh, JJ. | 140 | Am J Obstet Gynecol | 2016 |
| 9 | Ursodeoxycholic acid vs placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomized controlled trial | Chappell, LC. | 138 | Lancet | 2019 |
| 10 | ART Surveillance – United States, 2012 | Sunderam, S. | 136 | MMWR Surveillance Summaries | 2015 |
3.7 Keyword analysis
Keywords offer insights into current research trends and directions for future studies. A cooccurrence network was constructed using 138 keywords with at least 20 occurrences (Figure 11). The keywords were grouped into four clusters. Cluster 1 focused on interventions for preterm births, including terms, such as “cervical length,” “cerclage,” and “vaginal progesterone.” Cluster 2 highlighted risks associated with preterm births in twin pregnancies, with keywords including “ART,” “pregnancy complications,” and “body mass index.” Cluster 3 involved outcomes of preterm births in twin pregnancies, using terms such as “morbidity” and “mortality.” Cluster 4 included additional topics relevant to twin pregnancies and preterm birth.
Cooccurrence network of keywords with a minimum frequency of 20. Node sizes indicate keyword frequency, and lines represent connections between keywords. Colors indicate different clusters.
The top 20 keywords with the strongest citation bursts from 2014 to 2023 are shown in Figure 12. The keyword “perinatal outcome” emerged in 2020 and remains a focus to date. Similarly, “neonatal outcome,” which also appeared in 2020, indicated the sustained interest in outcomes of preterm births in twin pregnancies.
Top 20 keywords with the strongest citation bursts by year.
4 Discussion
Twin pregnancies have emerged as a significant focus of research due to the increasing prevalence attributed to advancements in ART and the increasing maternal age at conception [3]. This trend has brought a concomitant increase in twin-related complications and comorbidities, necessitating distinct management strategies compared to singleton pregnancies [12,13]. For example, low-molecular-weight heparin has demonstrated efficacy in preventing preeclampsia, treating fetal growth restriction, and reducing the risk of venous thromboembolism during twin pregnancies [14]. However, the relationship between inherited thrombophilia and adverse thrombotic pregnancy outcomes remains uncertain [15], highlighting the need for further exploration of its application in twin pregnancies [16]. These gaps suggest the substantial scope for research on optimizing maternal and fetal care in twin pregnancies and the related complications [5].
From 2014 to 2023, the number of publications on twin pregnancies steadily increased. The US, as the leading contributor, hosts many of the top publishing institutions, reflecting its pivotal role in advancing the field. China and England also ranked among the top three countries by publication volume, forming collaborative networks with other nations and institutions. These findings demonstrate the global commitment for investigating preterm births in twin pregnancies.
Among the top ten cited and cocited journals, the American Journal of Obstetrics and Gynecology holds the highest rank, highlighting its critical role as a platform for disseminating impactful research in obstetrics and gynecology. This dominance indicates the journal’s relevance for future submissions in this field.
Despite the growing body of literature, studies specifically addressing preterm births in twin pregnancies remain a relatively small proportion of the overall research landscape. Clinical practice, particularly prevention, is a cornerstone of this field. For instance, studies on vaginal progesterone for women with a short cervix during the mid-trimester [17] and the use of cervical pessaries in multiple pregnancies [18] have shown promise in reducing preterm delivery and neonatal morbidity. These interventions exemplify how research findings can translate into effective clinical strategies, with progesterone and pessaries now widely recognized as preventive measures in twin pregnancies [3,6].
The diversity of research approaches, spanning epidemiological studies, guidelines, reviews, and clinical trials, reflects the multifaceted nature of the field. While the ultimate goal is to comprehensively understand preterm births in twin pregnancies and guide clinical practice, many aspects remain enigmatic, necessitating further investigation.
Keyword analysis provided insight into evolving research priorities [19]. “Perinatal outcome” has shown the strongest citation burst in recent years, maintaining a consistent upward trend [20,21]. Keywords, such as “increased risk,” emphasize the importance of identifying risk factors [8,22], while “short cervix” highlights the significance of cervical incompetence as a critical issue in twin pregnancies [23,24]. These findings indicate that clinical practice remains the dominant research focus, with ongoing efforts needed to address unresolved questions in the field.
5 Conclusion
This study provides a comprehensive overview of research trends on preterm births in twin pregnancies, analyzing contributions from countries, institutions, authors, journals, and references from 2014 to 2023. The data revealed an upward trend in publications, with the United States, China, and England emerging as leading contributors. Global collaboration networks among countries, institutions, and authors have been firmly established. Research in this area has primarily focused on clinical practice, including prevention strategies, risk factor identification, and perinatal outcomes. These findings offer valuable insights into past advancements and outline directions for future exploration, emphasizing the importance of continued efforts to address the complexities of preterm births in twin pregnancies.
Acknowledgements
Not applicable.
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Funding information: This research was funded by the Natural Science Foundation of Hunan Province (2022JJ40789, 2023JJ40958), the China Postdoctoral Science Foundation (2022M723555), and the National Natural Science Foundation of China (82301927, 82371700, 81974236, 81571516).
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Author contributions: Conceptualization: Biaobiao Wang and Jingrui Huang; data curation: Biaobiao Wang; formal analysis: Biaobiao Wang; funding acquisition: Weishe Zhang, Qi Li, and Jingrui Huang; investigation: Biaobiao Wang; methodology: Jingrui Huang; resources: Weishe Zhang, Qi Li, and Xiuqing Lv; writing – original draft: Biaobiao Wang; and writing – review and editing: Jingrui Huang.
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Conflict of interest: The authors state no conflict of interest.
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Data availability statement: All data generated or analyzed during this study are included in this published article.
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- A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
- Identifying early screening factors for depression in middle-aged and older adults: A cohort study
- Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
- Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
- High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
- RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
- Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
- Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
- The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
- Expression and clinical significance of ITGA3 in breast cancer
- Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
- rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
- Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
- Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
- Gender beliefs and legitimization of dating violence in adolescents
- Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
- Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
- Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
- Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
- Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
- Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
- GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
- Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
- MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
- Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
- Trends in research on preterm birth in twin pregnancy based on bibliometrics
- Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
- Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
- Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
- Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
- Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
- CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
- Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
- Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
- Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
- Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
- Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
- Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
- Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
- The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
- The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
- Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
- Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
- The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
- Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
- Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
- Correlation of serum calprotectin with outcome of acute cerebral infarction
- Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
- Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
- The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
- Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
- Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
- Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
- Analysis of serum metabolomics in patients with different types of chronic heart failure
- Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
- Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
- Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
- METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
- The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
- Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
- Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
- Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
- Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
- Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
- Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
- Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
- Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
- Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
- Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
- Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
- HALP score in Demodex blepharitis: A case–control study
- Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
- Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
- Comparison of the two intestinal anastomosis methods in pediatric patients
- Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
- Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
- Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
- Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
- Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
- Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
- Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
- Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
- A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
- Review Articles
- The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
- Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
- Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
- Review of mechanisms and frontier applications in IL-17A-induced hypertension
- Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
- The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
- The application of augmented reality in robotic general surgery: A mini-review
- The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
- Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
- Plant polyphenols, terpenes, and terpenoids in oral health
- Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
- End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
- The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
- Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
- PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
- Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
- Giant borderline ovarian tumours – review of the literature
- Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
- Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
- Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
- Case Reports
- Delayed graft function after renal transplantation
- Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
- Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
- Giant right atrial hemangioma presenting with ascites: A case report
- Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
- EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
- Rapid Communication
- Biological properties of valve materials using RGD and EC
- Letter to the Editor
- Role of enhanced external counterpulsation in long COVID
- Expression of Concern
- Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
- Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
- Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
- Corrigendum
- Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
- Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
- Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
- Retraction
- Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
- Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
- Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
- Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
- The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
- Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
- Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
- Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
- Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
- Special Issue The evolving saga of RNAs from bench to bedside - Part III
- Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
- Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
- Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
- A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
- Special Issue Diabetes
- Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
- Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
- A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
- Special Issue Biomarker Discovery and Precision Medicine
- CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
Artikel in diesem Heft
- Research Articles
- Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
- Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
- Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
- Risk factors for severe adverse drug reactions in hospitalized patients
- Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
- Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
- CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
- Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
- Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
- Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
- Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
- Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
- Association between statin administration and outcome in patients with sepsis: A retrospective study
- Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
- A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
- Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
- Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
- Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
- Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
- Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
- The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
- Health literacy and health-related quality of life: The mediating role of irrational happiness
- Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
- Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
- Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
- Clinical analysis of ten cases of HIV infection combined with acute leukemia
- Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
- Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
- Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
- Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
- Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
- The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
- The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
- Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
- Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
- Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
- The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
- Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
- A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
- A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
- Identifying early screening factors for depression in middle-aged and older adults: A cohort study
- Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
- Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
- High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
- RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
- Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
- Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
- The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
- Expression and clinical significance of ITGA3 in breast cancer
- Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
- rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
- Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
- Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
- Gender beliefs and legitimization of dating violence in adolescents
- Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
- Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
- Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
- Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
- Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
- Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
- GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
- Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
- MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
- Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
- Trends in research on preterm birth in twin pregnancy based on bibliometrics
- Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
- Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
- Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
- Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
- Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
- CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
- Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
- Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
- Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
- Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
- Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
- Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
- Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
- The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
- The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
- Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
- Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
- The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
- Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
- Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
- Correlation of serum calprotectin with outcome of acute cerebral infarction
- Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
- Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
- The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
- Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
- Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
- Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
- Analysis of serum metabolomics in patients with different types of chronic heart failure
- Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
- Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
- Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
- METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
- The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
- Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
- Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
- Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
- Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
- Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
- Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
- Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
- Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
- Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
- Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
- Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
- HALP score in Demodex blepharitis: A case–control study
- Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
- Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
- Comparison of the two intestinal anastomosis methods in pediatric patients
- Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
- Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
- Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
- Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
- Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
- Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
- Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
- Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
- A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
- Review Articles
- The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
- Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
- Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
- Review of mechanisms and frontier applications in IL-17A-induced hypertension
- Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
- The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
- The application of augmented reality in robotic general surgery: A mini-review
- The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
- Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
- Plant polyphenols, terpenes, and terpenoids in oral health
- Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
- End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
- The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
- Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
- PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
- Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
- Giant borderline ovarian tumours – review of the literature
- Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
- Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
- Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
- Case Reports
- Delayed graft function after renal transplantation
- Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
- Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
- Giant right atrial hemangioma presenting with ascites: A case report
- Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
- EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
- Rapid Communication
- Biological properties of valve materials using RGD and EC
- Letter to the Editor
- Role of enhanced external counterpulsation in long COVID
- Expression of Concern
- Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
- Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
- Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
- Corrigendum
- Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
- Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
- Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
- Retraction
- Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
- Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
- Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
- Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
- The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
- Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
- Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
- Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
- Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
- Special Issue The evolving saga of RNAs from bench to bedside - Part III
- Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
- Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
- Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
- A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
- Special Issue Diabetes
- Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
- Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
- A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
- Special Issue Biomarker Discovery and Precision Medicine
- CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
