Home Medicine Identifying early screening factors for depression in middle-aged and older adults: A cohort study
Article Open Access

Identifying early screening factors for depression in middle-aged and older adults: A cohort study

  • Guanqun Chao EMAIL logo , Lan Zhang , Zheli Zhan and Yang Bao
Published/Copyright: March 19, 2025
Download Article (PDF)
Open Medicine
From the journal Open Medicine Volume 20 Issue 1

Abstract

Objective

This study aims to explore the current status of depression and related factors in middle-aged and elderly people in China using a cohort database with multi-year follow-up.

Methods

The study population for this project was derived from the China Health and Retirement Longitudinal Study. Participants were divided into control and depression groups based on scores from the Center for Epidemiological Research Depression Scale. Continuous variables were compared using t-tests or Mann–Whitney U tests, while categorical variables were compared using chi-square tests. A multivariate logistic regression model was employed to evaluate factors associated with depression.

Results

A total of 9,749 participants were included in the study. Correlation analyses revealed that age, body mass index, diastolic blood pressure, waist circumference, total cholesterol, uric acid, and length of sleep were significantly associated with depression (p < 0.05). Women exhibited a higher risk of depression in middle and old age compared to men (p < 0.05). An increase in waist circumference was associated with a decreased risk of depression (p < 0.05). Longer sleep duration and higher educational levels were also associated with a reduced risk of depression (p < 0.05). Unfavorable marital status and decreased frequency of alcohol consumption were found to increase the risk of depression (p < 0.05).

Conclusion

In middle-aged and elderly individuals, women, low education level, and experiencing dissatisfaction in marriage are connected with a high risk of depression. On the other hand, increased waist circumference, moderate alcohol consumption, and longer sleep duration are connected with a low risk of depression.

Keywords: depression; CHARLS; risk factor; middle-aged and elderly people

1 Introduction

Depression is a common mental disorder caused by the interaction of biological, psychological, and social factors [1]. Depression is considered to be one of the main causes of disability due to the large number of lives lost, but there are still problems, such as non-response and partial response to antidepressant treatment [2]. As a mental illness, depression affects approximately 5% of the global population, and researchers believe that its underlying mechanisms involve cytokines, hormones, oxidative stress, and neuropeptides [3]. Studies have found that depressed patients are prone to elevated blood lipids, which is why depression is at increased risk of cardiovascular events [4]. Additionally, researchers have discovered that major depressive disorder is linked to age-related negative outcomes and overlaps with biological changes associated with aging [5]. This suggests that depression may be connected to the aging process, highlighting the urgent need for prevention and intervention strategies targeting middle-aged and elderly individuals.

There have been numerous studies conducted on risk factors for depression, but the results remain somewhat controversial. Specifically, when it comes to depression in older adults, there is a large body of research; however, the conclusions drawn from these studies are still unclear. In studies of veterans, age was found to be a negative predictor of depression, whereas secondary analysis found that age was a predictor of remission, so age is not just a predictor of depression outcome [6]. The depressive state is associated with physiological changes such as hypercortisolemia, activation of inflammation, and reduction of nutritional factors [7]. The study found that more than half of the elderly in Egypt have depression, and its risk factors mainly include female gender, unemployment, chronic disease, and low income [8]. In addition to this, living environment, social support, and autonomy can also influence depressive status, so studies have found that titles in nursing homes are more likely to be depressed, especially in low- and middle-income countries [9]. Depression is also affected by genetics, and studies have found that the heritability of depression is at 37%, and genetic imaging can explore brain abnormalities caused by genetic variations, which is used to test for depression [10]. It is evident that depression, particularly in relation to aging, has garnered significant attention worldwide. Consequently, research on depression in the elderly has become a prominent area of focus. At present, most of the research on depression focuses on adolescents and the elderly, and there are relatively few studies on middle-aged people. However, due to the current social state, life pressure, and work pressure, middle-aged people are the group of people who are in an abnormal mental and psychological state. With the process of an aging society, the elderly are a group of people who need care. For this purpose, we selected middle-aged and older people to carry out the study. This study aims to utilize a cohort database with multi-year follow-up in China to explore the current status of depression and its related factors in middle-aged and elderly individuals.

2 Method

2.1 Study population

The study population for this project was derived from the China Health and Retirement Longitudinal Study (CHARLS) [11]. The study comprised a representative sample of Chinese individuals aged 45 years and older, with baseline surveys conducted in 2011 and subsequent follow-ups conducted every 2–3 years. CHARLS received approval from the Biomedical Ethics Review Committee of Peking University and obtained informed consent from all participants.

2.2 Grouping

This study utilized the Center for Epidemiological Research Depression Scale (CES-D-10) to evaluate depression. The CES-D-10 has been widely employed to assess depressive symptoms in older adults and has demonstrated effectiveness [12,13]. Each item on this scale is rated on a scale of 0–3, with higher cumulative scores indicating greater levels of depression. Scores equal to or exceeding 10 are indicative of depressive symptoms [14]. Participants were categorized into control and depression groups based on their scores.

2.3 Questionnaire content

The study included participants’ education level (no formal education; did not finish primary school; Sishu/home school; elementary school; middle school; high school; vocational school; two-/three-year college/associate degree; four-year college/bachelor’s degree; master’s degree; doctoral degree/Ph.D.), marital status (married and living with spouse; married but not living with spouse temporarily for reasons such as work; separated, not living together as a couple anymore; divorced; widowed; never married), and alcohol consumption (more than once a month; less than once a month; none).

2.4 Relevant inspection indicators and inspection indicators

The study included several indicators such as age, gender, height, weight, waist circumference, blood pressure, blood lipids, uric acid, blood sugar, sleep duration, and more. Body mass index (BMI) is calculated as weight (kg) divided by height (m) squared.

2.5 Statistical analysis

All data were analyzed using SPSS 25.0. A t-test or Mann–Whitney U test was used for comparing continuous variables, while a chi-square test was used for comparing categorical variables. The t/χ2 tests were employed to assess the differences in demographics and characteristics between the two groups. A multivariate logistic regression model was utilized to evaluate the factors associated with depression. The mean of continuous data is presented as mean ± SD. Statistical significance was set at p < 0.05.

  1. Informed consent/Patient consent: All participants signed informed consent at the time of participation.

  2. Ethical statement: Approval for the original CHARLS was obtained from the Biomedical Ethics Review Committee of Peking University (IRB00001052-11015).

3 Results

3.1 Sample inclusion

The databases from 2015 and 2018 were eventually combined based on the ID of the subjects, resulting in a total of 21,678 subjects. Invalid data, such as missing information on sex, age, questionnaire responses, biochemical indicators, blood pressure, pulse, etc., were subsequently removed. As a result, 9,749 participants were included in the final analysis (Figure 1).

Figure 1 Flow diagram.
Figure 1

Flow diagram.

3.2 Comparison of baseline data between the depression group and the control group

Participants aged 45 years or older were included, resulting in an average age of 66.57 ± 9.28 (Table 1). Notably, there was a significant difference in age between the depression group (66.89 ± 9.13) and the control group (66.38 ± 9.36) (p < 0.05). Additionally, the proportion of women in the depressed group was higher (62.7%), while the control group had a higher proportion of males (52.5%). This gender difference between the two groups was statistically significant (p < 0.05). Furthermore, questionnaire surveys revealed significant differences in education, marital status, and alcohol consumption between the depression group and the control group (p < 0.05). Moreover, there were notable differences in diastolic blood pressure, BMI, waist circumference, total cholesterol, uric acid level, and sleep duration between the depression group and the control group (p < 0.05).

Table 1

Comparison of baseline data between the depression group and the control group

Overall Control group Depression group p
Age (years, mean ± SD) 66.57 ± 9.28 66.38 ± 9.36 66.89 ± 9.13 0.008
Gender (n, %) Male: 4,562 (46.8) Male: 3,185 (52.5) Male: 1,377 (37.3) 0.000
Female: 5,187 (53.2) Female: 2,876 (47.5) Female: 2,311 (62.7)
Education (n, %) No formal education (illiterate): 1,904 (19.5) No formal education (illiterate): 991 (16.4) No formal education (illiterate): 913 (24.8) 0.000
Did not finish primary school: 2,101 (21.6) Did not finish primary school: 1,139 (18.8) Did not finish primary school: 962 (26.1)
Sishu/home school: 7 (0.1) Sishu/home school: 5 (0.1) Sishu/home school: 2 (0.1)
Elementary school: 2,360 (24.2) Elementary school: 1,470 (24.3) Elementary school: 890 (24.1)
Middle school: 2,280 (23.4) Middle school: 1,622 (26.8) Middle school: 658 (17.8)
High school: 754 (7.7) High school: 554 (9.1) High school: 200 (5.4)
Vocational school: 199 (2.0) Vocational school: 156 (2.6) Vocational school: 43 (1.2)
Two-/three-year college/associate degree: 86 (0.9) Two-/three-year college/associate degree: 73 (1.2) Two-/three-year college/associate degree: 13 (0.4)
Four-year college/bachelor’s degree: 54 (0.6) Four-year college/bachelor’s degree: 49 (0.8) Four-year college/bachelor’s degree: 5 (0.1)
Master’s degree: 3 (0.0) Master’s degree: 1 (0.0) Master’s degree: 2 (0.1)
Doctoral degree/Ph.D.: 1 (0.0) Doctoral degree/Ph.D.: 1 (0.0) Doctoral degree/Ph.D.: 0 (0.0)
Marital status (n, %) Married and live with spouse: 8,003 (82.1) Married and live with spouse: 5,150 (85.0) Married and live with spouse: 2,853 (77.4) 0.000
Married but don’t living with spouse temporarily for reasons such as work: 529 (5.4) Married but don’t living with spouse temporarily for reasons such as work: 287 (4.7) Married but don’t living with spouse temporarily for reasons such as work: 242 (6.6)
Separated, don’t live together as a couple anymore: 19 (0.2) Separated, don’t live together as a couple anymore: 10 (0.2) Separated, don’t live together as a couple anymore: 9 (0.2)
Divorced: 101 (1.0) Divorced: 59 (1.0) Divorced: 42 (1.1)
Widowed: 1053 (10.8) Widowed: 538 (8.9) Widowed: 515 (14.0)
Never married: 44 (0.5) Never married: 17 (0.3) Never married: 27 (0.7)
Blood pressure (systolic) (mmHg, mean ± SD) 129.63 ± 20.41 129.92 ± 20.38 129.14 ± 20.43 0.068
Blood pressure (diastolic) (mmHg, mean ± SD) 76.80 ± 12.21 77.10 ± 12.07 76.30 ± 12.42 0.002
BMI (kg/m2) 24.08 ± 3.62 24.16 ± 3058 23.95 ± 3.68 0.005
Waist circumference (cm, mean ± SD) 85.61 ± 12.94 86.15 ± 12.58 84.72 ± 1.46 0.000
Triglycerides (mg/dl, mean ± SD) 143.10 ± 91.32 143.97 ± 92.05 141.67 ± 90.11 0.227
Total cholesterol (mg/dl, mean ± SD) 183.45 ± 36.01 182.76 ± 35.37 184.59 ± 37.00 0.015
Glucose (mg/dl, mean ± SD) 102.66 ± 33.19 102.68 ± 32.16 102.62 ± 34.82 0.934
Uric acid (mg/dl, mean ± SD) 4.91 ± 1.37 5.00 ± 1.38 4.76 ± 1.36 0.000
Sleep (hours mean ± SD) 6.21 ± 1.92 6.54 ± 1.72 5.89 ± 2.12 0.000
Alcoholic beverage More than once a month: 2586 (26.5) More than once a month: 1834 (30.3) More than once a month: 752 (20.4) 0.000
Less than once a month: 739 (7.6) Less than once a month: 474 (7.8) Less than once a month: 265 (7.2)
None: 6424 (65.9) None: 3753 (61.9) None: 2671 (72.4)

Note: BMI: body mass index. p < 0.05 was considered statistically significant.

3.3 Correlation analysis of depression and various indicators

We conducted correlation analyses (Table 2), which included variables such as age, BMI, blood pressure, pulse, waist circumference, sleep duration, and biochemical indicators. We found several variables to be associated with depression, including age, BMI, diastolic blood pressure, waist circumference, total cholesterol, uric acid, and sleep duration. There was a positive correlation between age and depression scores; depression is more likely to occur with age. Total cholesterol was also positively correlated with depression scores. BMI, blood pressure (diastolic), waist circumference, uric acid, and sleep duration were all indices that were negatively correlated with depression scores.

Table 2

Correlation analysis of depression and various indicators

Depression
r/r s p
Age 0.039** 0.000
BMI −0.038** 0.000
Blood pressure (systolic) −0.018 0.068
Blood pressure (diastolic) −0.036** 0.000
Pulse 0.015 0.130
Waist circumference −0.062** 0.000
Triglycerides −0.011 0.271
Total cholesterol 0.031** 0.002
Glucose 0.000 0.969
Uric acid −0.098** 0.000
Sleep −0.266** 0.000

Note: BMI: body mass index. p < 0.05 was considered statistically significant.

** represents p < 0.05.

3.4 Multivariate logistic regression analysis of depression and related variables

We incorporated age, gender, waist circumference, and other variables to construct multivariate logistic regression equations (Table 3). The results revealed that women had a higher risk of depression in middle and old age compared to men, and this difference was statistically significant (OR = 1.277, 95% CI 1.143–1.426, p < 0.05). Additionally, an increase in waist circumference was associated with a decreased risk of depression in middle-aged and elderly individuals, and this difference was statistically significant (OR = 0.995, 95% CI 0.990–0.999, p < 0.05). Moreover, an increase in sleep duration was found to be associated with a decreased risk of depression in middle-aged and elderly individuals, and this difference was statistically significant (OR = 0.802, 95% CI 0.783–0.821, p < 0.05). Furthermore, an improvement in educational level was associated with a decreased risk of depression in middle-aged and elderly individuals, and this difference was statistically significant (OR = 0.855, 95% CI 0.834–0.877, p < 0.05). Moreover, a worse marital status was found to increase the risk of depression in middle-aged and older adults, and this difference was statistically significant (OR = 1.104, 95% CI 1.068–1.142, p < 0.05). Lastly, a decreased frequency of alcohol consumption was associated with an increased risk of depression in middle-aged and older adults, and this difference was statistically significant (OR = 1.144, 95% CI 1.081–1.210, p < 0.05).

Table 3

Multivariate logistic regression analysis of depression and related variables

Variable b Standard error Wald Chi-square value p OR 95% CI
Gender 0.244 0.057 18.607 0.000 1.277 1.143–1.426
Age −0.004 0.003 1.804 0.179 0.996 0.991–1.002
BMI −0.001 0.009 0.026 0.973 0.999 0.982–1.016
Blood pressure (systolic) −0.002 0.001 2.017 0.156 0.998 0.995–1.001
Blood pressure (diastolic) 0.001 0.002 0.350 0.554 1.001 0.997–1.006
Pulse 0.000 0.002 0.011 0.917 1.000 0.996–1.004
Waist circumference −0.005 0.002 4.922 0.027 0.995 0.990–0.999
Triglycerides 0.000 0.000 0.001 0.971 1.000 0.999–1.001
Total cholesterol 0.000 0.001 0.504 0.478 1.000 0.999–1.002
Glucose 0.001 0.001 0.608 0.436 1.001 0.999–1.002
Uric acid −0.023 0.019 1.519 0.218 0.977 0.942–1.014
Sleep −0.221 0.012 348.897 0.000 0.802 0.783–0.821
Education −0.156 0.013 145.780 0.000 0.855 0.834–0.877
Marital status 0.099 0.017 33.712 0.000 1.104 1.068–1.142
Alcoholic beverage 0.134 0.029 21.896 0.000 1.144 1.081–1.210

Note: BMI: body mass index. p < 0.05 was considered statistically significant.

4 Discussion

Current theories of pathophysiology of depression include the monoamine theory and the hypothalamic–pituitary–adrenal (HPA) axis hyperactivity hypothesis, which states that monoamine neurotransmitter deficiencies and stressful events are responsible for the development of depressive episodes [15]. Studies have found that adults and adolescents with depression have different neurological changes; that is, depression has age-specific neurological changes [16]. To further understand the association between age, gender, and depression in older adults, a study was conducted, expanding the age range to include individuals aged 45 years and older for data analysis. Comparisons between the depression group and the control group revealed differences in age and sex. Correlation analysis further supported the significance of age in relation to depression. Multivariate logistic regression analysis indicated that gender is related to the high risk of depression in middle-aged and elderly individuals, while age itself does not appear to be a significant factor. Our study suggested that the occurrence of depression in middle-aged and elderly people in China is still related to gender, and it is more significant in women. Studies have found that women with depression are more likely to have symptoms than men, and at the same time, they are accompanied by an increase in inflammatory indicators, and some inflammatory indicators are not obvious in male patients with depression [17]. In further proteomic studies, it was found that the main biological processes in which female depression is affected by the relevant proteins are related to immune inflammation control [18]. The treatment of depression is still a difficult question to be studied, and recent studies have found that deep brain stimulation is more effective for women than for men [19]. Current research shows that women’s gender is associated with a risk of depression. The reason for this is that the immune system dysfunction associated with depression appears to be gender-specific, so many drug anti-inflammatory drugs exhibit antidepressant effects, and there are gender differences, but there are few studies on this gender difference, and sex hormones are an important factor in this gender difference [20].

Depression and obesity are two significant public health concerns that are currently receiving considerable attention. Some scholars have proposed that there are common biological pathways linking the two conditions, including genetic factors, metabolic factors, and emotional regulation [21]. Researchers believe that depression is related to obesity, and depressed people are more inclined to be obese, which leads to poor eating habits and lifestyles [22]. Several studies have found a correlation between depression and obesity or BMI. However, it has also been suggested that the reverse effect may be true, meaning that depression could lead to increased food intake and subsequent obesity [23]. In our study, we also examined the relationship between depression and obesity in middle-aged and elderly individuals over the age of 45 in China. We found that both BMI and waist circumference were associated with depression. However, BMI was not identified as an important correlated factor for depression after considering other relevant factors, and an increase in waist circumference was found to be associated with a reduced risk of developing depression. Obesity and depression go both ways, with altered gut microbiomes in obese individuals leading to systemic inflammation and mood disorders [24]. Further studies found that the recurrence of depression received gender modification, with recurrence of depression in women positively correlated with obesity-related traits, and in men, both recurrence of depression and subcutaneous fat in men [25]. This finding helps to explain why BMI was associated with depression in our study, while not being identified as a risk factor for depression. Overall, the relationship between depression and obesity is complex and multifaceted. Further research is needed to better understand the underlying mechanisms and to develop effective interventions for individuals affected by both conditions. Obesity and depression have been found to be closely related, with each potentially exacerbating the other. However, it is important to note that this does not necessarily imply a causal relationship between weight and depression. Instead, obesity and depression are often considered comorbidities, meaning that they frequently occur together but are not directly linked. These comorbidities can be attributed to bidirectional relationships and common genetic factors [26]. Interestingly, our study discovered that an increased waist circumference actually reduces the risk of depression, which brings to mind the “Jolly Fat hypothesis” which is that higher BMI is significantly associated with better mental health conditions and events, and some studies have suggested that depression is inversely correlated with BMI in older women [27]. This finding contradicts some previous studies that have suggested a positive correlation between depression and central obesity. The discrepancy in results may be due to differences in the racial and genetic makeup of the populations included in the studies. It is also worth noting that our study only assessed depression through scoring, while other studies may have included participants who were receiving medication for depression. These factors could contribute to the conflicting results. Given the current state of research, it is more appropriate to study obesity and depression as comorbidities rather than as directly interrelated conditions.

Through questionnaires, we have discovered that participants’ level of education, marital status, alcohol consumption, and nighttime sleep duration are all factors associated with depression. Specifically, we found that individuals with lower education levels, worse marital statuses, and shorter sleep durations are at a higher risk of experiencing depression. The study found that both culture and income were associated with the aggravation of depression, and the higher the level of education and the lower the income, the more obvious the aggravation of depression [28]. For older adults, frailty and depression were positively correlated, with variables such as education level, income status, people living with them, regular medications, forgetting to take medications, urinary incontinence, hospitalization, and accidents found to influence frailty and depression [29]. Another study is consistent with our findings, suggesting that low educational attainment is associated with a risk of mental disorders, substance use disorders, and self-harm at all ages [30]. Marital status is a well-established potential risk factor for depression, but analysis across multiple countries suggests that unmarried people may be at greater risk of depression, and it is also related to gender and educational attainment [31]. Studies in older adults have found a correlation between reduced sleep and depression, and early detection of depressive states can predict future sleep disorders [32]. To further explore the mechanism, Mendelian randomization provided genetic evidence for an individual’s sleep characteristics and increased risk of depression and found a causal relationship between insomnia and daytime naps and an increased risk of depression [33]. Our study has found that longer sleep duration is associated with a reduced risk of depression. However, it is important to note that excessive sleep, or even excessive drowsiness, can also serve as an early warning sign of depression [34]. The mechanism of the correlation between sleep disorders and depression includes several aspects: (1) it is related to the activation and inflammation of the HPA axis, which leads to a decrease in serotonin synthesis, which affects other factors involved in the pathophysiology of neuropsychiatric disorders; and (2) changes in the gut microbiota affect the microbiota–gut–brain axis [35]. Therefore, we can conclude that a longer sleep duration within an appropriate time frame is more beneficial in reducing the risk of depression. Interestingly, our study also found that drinking less alcohol increases the risk of depression. A longitudinal population study conducted in Sweden revealed that individuals who never drink alcohol have a higher risk of depression compared to light drinkers, while those who engage in risky drinking have a higher risk of depression compared to non-risk drinkers [36]. In our study, the highest level of drinking was considered light drinking, as it occurred more than once a month, and the results were consistent with this finding. However, some researchers have suggested that moderate drinking does not have a clear protective association with depression in old age. It is worth noting that inaccurate reporting of the specific amount of alcohol consumed may contribute to this discrepancy [37]. Furthermore, there appears to be a bidirectional relationship between alcohol consumption and depression, as comorbidities of depression and alcohol addiction are frequently observed clinically. Depression can lead to increased alcohol consumption, and increased alcohol consumption may induce depression. The mechanism behind this relationship may be related to the activation and decline of hippocampal microglia [38]. A study in the United States found that different drinking frequencies had different effects on depression, and smoothed curve fitting revealed for the first time an “M-shaped” relationship between drinking frequency and depression [39]. In summary, adopting healthy lifestyle habits is crucial in reducing the risk of depression. Our research did not find a significant correlation between blood pressure, blood lipids, blood sugar, and the risk of depression in middle-aged and elderly individuals. However, there are many factors that affect depression. Studies have found that the residential environment can affect depression, and residential greening can effectively reduce the impact of other factors on depression and have a role in supporting mental health [40]. Socially isolated environmental conditions can also exacerbate depression, leading to a high incidence of depressive events [41]. Studies have found that the environment in which you live at a given age explains the psychological effects, so both the living environment and the living experience have an impact on depression [42].

Our study had several limitations that should be acknowledged. First, the grouping of depression was based on the current epidemiological general scale, which relies on subjective responses from the subjects. As a result, the accuracy of the depression diagnosis may not be sufficient. Second, there was a certain level of subjectivity in the questionnaire responses, leading to potential arbitrariness and a significant amount of data loss. This could have introduced certain inaccuracies in our findings. Third, our study did not include data on smoking, exercise, environment and chronic diseases, which could have influenced the results. The absence of these variables might have contributed to differences in the outcomes observed. It is important to note that our study utilized data from public databases. Fourth, this is a cross-sectional study, so causality cannot be accounted for. In future research, we plan to establish multicenter cohorts to gather more comprehensive data and conduct targeted and in-depth studies.

5 Conclusion

Depression is now widely acknowledged as a significant public health issue, and its prevalence among middle-aged and elderly individuals in China is on the rise. Various factors such as gender, waist circumference, sleep duration, education, marital status, and drinking habits have been found to be associated with depression in this population. Specifically, women, low education level, and experiencing dissatisfaction in marriage are connected with the high risk of depression among middle-aged and elderly individuals. On the other hand, increased waist circumference, moderate alcohol consumption, and longer sleep duration are connected with the low risk of depression.

  1. Funding information: The authors state no funding involved.

  2. Author contributions: Guanqun Chao wrote the article, Lan Zhang, Zheli Zhan, and Yang Bao did the analysis.

  3. Conflict of interest: The authors state no conflict of interest.

  4. Data availability statement: The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

References

[1] Li J, Zhang K, Zhao T, Huang W, Hou R, Wang S, et al. Acupressure for depression: A systematic review and meta-analysis. Asian J Psychiatr. 2024;92:103884.10.1016/j.ajp.2023.103884Search in Google Scholar PubMed

[2] Alderman BL, Perdue HM, Sarwani AH. Exercise for the prevention and treatment of depression. Curr Top Behav Neurosci. 2024;67:157–75.10.1007/7854_2024_496Search in Google Scholar PubMed

[3] Harsanyi S, Kupcova I, Danisovic L, Klein M. Selected biomarkers of depression: What are the effects of cytokines and inflammation? Int J Mol Sci. 2022;24(1):578.10.3390/ijms24010578Search in Google Scholar PubMed PubMed Central

[4] Xu DR, Gao X, Zhao LB, Liu SD, Tang G, Zhou CJ, et al. Association between triglyceride and depression: A systematic review and meta-analysis. PLoS One. 2024;19(10):e0311625.10.1371/journal.pone.0311625Search in Google Scholar PubMed PubMed Central

[5] Lorenzo EC, Kuchel GA, Kuo CL, Moffitt TE, Diniz BS. Major depression and the biological hallmarks of aging. Ageing Res Rev. 2023;83:101805.10.1016/j.arr.2022.101805Search in Google Scholar PubMed PubMed Central

[6] Walker NC, Philip NS, Kozel FA, Yesavage JA, Madore MR. Effectiveness of prefrontal transcranial magnetic stimulation for depression in older US military veterans. Am J Geriatr Psychiatry. 2024;32(3):315–25.10.1016/j.jagp.2023.10.010Search in Google Scholar PubMed PubMed Central

[7] Wong M, Kiss A, Herrmann N, Lanctôt KL, Gallagher D. Modifiable risk factors associated with cognitive decline in late life depression: Findings from the Canadian longitudinal study on aging: Facteurs de risque modifiables associes au declin cognitif dans la depression en fin de vie: Constatations de l’Etude longitudinale canadienne sur le vieillissement. Can J Psychiatry. 2024;69(9):708–16.10.1177/07067437241255095Search in Google Scholar PubMed PubMed Central

[8] Ahmed H, Khaled H, Allam AA, Alodini B, Azzam A, Hjazeen AA, et al. Depression in geriatrics: A systematic review and meta-analysis of prevalence and risk factors in Egypt. BMC Geriatr. 2024;24(1):930.10.1186/s12877-024-05484-2Search in Google Scholar PubMed PubMed Central

[9] Wang Q, Huang X, Liu M, Wang C, Sun Z, Huang C, et al. Prevalence and risk factors of depression among elderly people in nursing homes from 2012 to 2022: A systematic review and meta-analysis. Aging Ment Health. 2024;28(12):1569–80.10.1080/13607863.2024.2367044Search in Google Scholar PubMed

[10] Jindal M, Chhetri A, Ludhiadch A, Singh P, Peer S, Singh J, et al. Neuroimaging genomics a predictor of major depressive disorder (MDD). Mol Neurobiol. 2024;61(6):3427–40.10.1007/s12035-023-03775-0Search in Google Scholar PubMed

[11] Zhao Y, Hu Y, Smith JP, Strauss J, Yang G. Cohort profile: The China Health and Retirement Longitudinal Study (CHARLS). Int J Epidemiol. 2014;43(1):61–8.10.1093/ije/dys203Search in Google Scholar

[12] Boey KW. Cross-validation of a short form of the CES-D in Chinese elderly. Int J Geriatr Psychiatry. 1999;14(8):608–17.10.1002/(SICI)1099-1166(199908)14:8<608::AID-GPS991>3.0.CO;2-ZSearch in Google Scholar

[13] Cheng HG, Chen S, McBride O, Phillips MR. Prospective relationship of depressive symptoms, drinking, and tobacco smoking among middle-aged and elderly community-dwelling adults: Results from the China Health and Retirement Longitudinal Study (CHARLS). J Affect Disord. 2016;195:136–43.10.1016/j.jad.2016.02.023Search in Google Scholar

[14] Luo H, Li J, Zhang Q, Cao P, Ren X, Fang A, et al. Obesity and the onset of depressive symptoms among middle-aged and older adults in China: Evidence from the CHARLS. BMC Public Health. 2018;18(1):909.10.1186/s12889-018-5834-6Search in Google Scholar

[15] Serefko A, Jach ME, Pietraszuk M, Świąder M, Świąder K, Szopa A. Omega-3 polyunsaturated fatty acids in depression. Int J Mol Sci. 2024;25(16):8675.10.3390/ijms25168675Search in Google Scholar

[16] Bore MC, Liu X, Huang X, Kendrick KM, Zhou B, Zhang J, et al. Common and separable neural alterations in adult and adolescent depression - Evidence from neuroimaging meta-analyses. Neurosci Biobehav Rev. 2024;164:105835.10.1016/j.neubiorev.2024.105835Search in Google Scholar

[17] Jarkas DA, Villeneuve AH, Daneshmend AZB, Villeneuve PJ, McQuaid RJ. Sex differences in the inflammation-depression link: A systematic review and meta-analysis. Brain Behav Immun. 2024;121:257–68.10.1016/j.bbi.2024.07.037Search in Google Scholar

[18] Xue X, Demirci D, Lenze EJ, Reynolds Iii CF, Mulsant BH, Wetherell JL, et al. Sex differences in plasma proteomic markers in late-life depression. Psychiatry Res. 2024;334:115773.10.1016/j.psychres.2024.115773Search in Google Scholar

[19] Patel E, Ramaiah P, Mamaril-Davis JC, Bauer IL, Koujah D, Seideman T, et al. Outcome differences between males and females undergoing deep brain stimulation for treatment-resistant depression: Systematic review and individual patient data meta-analysis. J Affect Disord. 2024;351:481–8.10.1016/j.jad.2024.01.251Search in Google Scholar

[20] McCallum RT, Thériault RK, Manduca JD, Russell ISB, Culmer AM, Doost JS, et al. Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats. Biol Sex Differ. 2024;15(1):16.10.1186/s13293-024-00589-0Search in Google Scholar

[21] Milaneschi Y, Simmons WK, van Rossum EFC, Penninx BW. Depression and obesity: Evidence of shared biological mechanisms. Mol Psychiatry. 2019;24(1):18–33.10.1038/s41380-018-0017-5Search in Google Scholar PubMed

[22] Jitte S, Keluth S, Bisht P, Wal P, Singh S, Murti K, et al. Obesity and depression: Common link and possible targets. CNS Neurol Disord Drug Targets. 2024;23(12):1425–49.10.2174/0118715273291985240430074053Search in Google Scholar PubMed

[23] Ha H, Han C, Kim B. Can obesity cause depression? A pseudo-panel analysis. J Prev Med Public Health. 2017;50(4):262–7.10.3961/jpmph.17.067Search in Google Scholar PubMed PubMed Central

[24] Selman A, Dai J, Driskill J, Reddy AP, Reddy PH. Depression and obesity: Focus on factors and mechanistic links. Biochim Biophys Acta Mol Basis Dis. 2024;1871(1):167561.10.1016/j.bbadis.2024.167561Search in Google Scholar PubMed

[25] Bannert U, Siewert-Markus U, Klinger-König J, Grabe HJ, Stracke S, Dörr M, et al. Major depression recurrence is associated with differences in obesity-related traits in women, but not in men. Eur Psychiatry. 2024;67(1):e55.10.1192/j.eurpsy.2024.1764Search in Google Scholar PubMed PubMed Central

[26] Liao SF, Su CY, Su MH, Chen CY, Chen CY, Lin YF, et al. Associations of polygenic risks, depression, and obesity-related traits in Taiwan Biobank. J Affect Disord. 2023;320:397–403.10.1016/j.jad.2022.09.149Search in Google Scholar PubMed

[27] Liu X, Chen S, Tan A, Zhou J, Liu W. Stay slim or get fat?: An examination of the “Jolly Fat” effect in Chinese older adults. Risk Manag Healthc Policy. 2021;14:1271–9.10.2147/RMHP.S302270Search in Google Scholar PubMed PubMed Central

[28] Ormiston CK, Lopez D, Montiel Ishino FA, McNeel TS, Williams F. Acculturation and depression increase trouble sleeping in Mexican immigrant adults. PLoS One. 2024;19(10):e0311288.10.1371/journal.pone.0311288Search in Google Scholar PubMed PubMed Central

[29] Biçak Ayik D, Cengiz Z, Isik K. The effect of frailty levels of older individuals on their mental well-being and depression levels. Psychogeriatrics. 2024;24(3):637–44.10.1111/psyg.13110Search in Google Scholar PubMed

[30] Li B, Allebeck P, Burstöm B, Danielsson AK, Degenhardt L, Eikemo TA, et al. Educational level and the risk of mental disorders, substance use disorders and self-harm in different age-groups: A cohort study covering 1,6 million subjects in the Stockholm region. Int J Methods Psychiatr Res. 2023;32(4):e1964.10.1002/mpr.1964Search in Google Scholar PubMed PubMed Central

[31] Zhai X, Tong HHY, Lam CK, Xing A, Sha Y, Luo G, et al. Association and causal mediation between marital status and depression in seven countries. Nat Hum Behav. 2024;8(12):2392–405. 10.1038/s41562-024-02033-0.Search in Google Scholar PubMed

[32] Didikoglu A, Guler ES, Turk HK, Can K, Erim AN, Payton A, et al. Depression in older adults and its associations with sleep and synaptic density. J Affect Disord. 2024;366:379–85.10.1016/j.jad.2024.08.186Search in Google Scholar PubMed

[33] Qiu-Qiang Z, Wei-Wei Y, Shan-Shu H, Yi-Ran L. Mendelian randomization of individual sleep traits associated with major depressive disorder. J Affect Disord. 2024;365:105–11.10.1016/j.jad.2024.08.068Search in Google Scholar PubMed

[34] Lopez R, Barateau L, Evangelista E, Dauvilliers Y. Depression and hypersomnia: A complex association. Sleep Med Clin. 2017;12(3):395–405.10.1016/j.jsmc.2017.03.016Search in Google Scholar PubMed

[35] Manosso LM, Duarte LA, Martinello NS, Mathia GB, Réus GZ. Circadian rhythms and sleep disorders associated to major depressive disorder: Pathophysiology and therapeutic opportunities. CNS Neurol Disord Drug Targets. 2024;23(9):1085–100.10.2174/0118715273254093231020052002Search in Google Scholar PubMed

[36] Gémes K, Forsell Y, Janszky I, László KD, Lundin A, Ponce De Leon A, et al. Moderate alcohol consumption and depression – a longitudinal population-based study in Sweden. Acta Psychiatr Scand. 2019;139(6):526–35.10.1111/acps.13034Search in Google Scholar PubMed

[37] García-Esquinas E, Ortolá R, Galán I, Soler-Vila H, Laclaustra M, Rodríguez-Artalejo F. Moderate alcohol drinking is not associated with risk of depression in older adults. Sci Rep. 2018;8(1):11512.10.1038/s41598-018-29985-4Search in Google Scholar PubMed PubMed Central

[38] Hu P, Wang D, Zhang Y, Cai Z, Ye T, Tong L, et al. Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice. Neuropharmacology. 2020;170:108054.10.1016/j.neuropharm.2020.108054Search in Google Scholar PubMed

[39] Qi P, Huang M, Zhu H. Association between alcohol drinking frequency and depression among adults in the United States: a cross-sectional study. BMC Psychiatry. 2024;24(1):836.10.1186/s12888-024-06296-9Search in Google Scholar PubMed PubMed Central

[40] Yang Y, Zhang Y, Sheng S. Residential greenness for mitigating impacts of extreme heat events on depression and supporting mental health. Front Public Health. 2023;11:1310410.10.3389/fpubh.2023.1310410Search in Google Scholar PubMed PubMed Central

[41] Zhao X, Ruan Z, Tian Y, Du W, Fan L. Estimating the joint effect of household solid fuel use and social isolation on depression among middle-aged and older adults in China. Sci Total Env. 2023;901:166411.10.1016/j.scitotenv.2023.166411Search in Google Scholar PubMed

[42] Kou N, Suo J, Wu M, Song B. The influence of residential Environment and residential experience on psychological depression in older adults: Evidence from China and Europe. Health Place. 2024;88:103264.10.1016/j.healthplace.2024.103264Search in Google Scholar PubMed

Received: 2024-07-12
Revised: 2025-01-15
Accepted: 2025-02-03
Published Online: 2025-03-19

© 2025 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Articles in the same Issue

  1. Research Articles
  2. Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
  3. Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
  4. Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
  5. Risk factors for severe adverse drug reactions in hospitalized patients
  6. Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
  7. Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
  8. CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
  9. Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
  10. Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
  11. Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
  12. Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
  13. Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
  14. Association between statin administration and outcome in patients with sepsis: A retrospective study
  15. Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
  16. A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
  17. Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
  18. Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
  19. Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
  20. Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
  21. Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
  22. The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
  23. Health literacy and health-related quality of life: The mediating role of irrational happiness
  24. Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
  25. Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
  26. Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
  27. Clinical analysis of ten cases of HIV infection combined with acute leukemia
  28. Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
  29. Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
  30. Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
  31. Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
  32. Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
  33. The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
  34. The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
  35. Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
  36. Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
  37. Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
  38. The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
  39. Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
  40. A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
  41. A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  42. Identifying early screening factors for depression in middle-aged and older adults: A cohort study
  43. Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
  44. Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
  45. High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
  46. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Investigation of the pathogenic variants induced Sjogren’s syndrome in Turkish population
  128. Nucleotide metabolic abnormalities in post-COVID-19 condition and type 2 diabetes mellitus patients and their association with endocrine dysfunction
  129. TGF-β–Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization
  130. Ultrasound-guided unilateral versus bilateral erector spinae plane block for postoperative analgesia of patients undergoing laparoscopic cholecystectomy
  131. Profiling gut microbiome dynamics in subacute thyroiditis: Implications for pathogenesis, diagnosis, and treatment
  132. Delta neutrophil index, CRP/albumin ratio, procalcitonin, immature granulocytes, and HALP score in acute appendicitis: Best performing biomarker?
  133. Anticancer activity mechanism of novelly synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative on colon cancer cells
  134. H2valdien3 arrests the cell cycle and induces apoptosis of gastric cancer
  135. Prognostic relevance of PRSS2 and its immune correlates in papillary thyroid carcinoma
  136. Association of SGLT2 inhibition with psychiatric disorders: A Mendelian randomization study
  137. Motivational interviewing for alcohol use reduction in Thai patients
  138. Luteolin alleviates oxygen-glucose deprivation/reoxygenation-induced neuron injury by regulating NLRP3/IL-1β signaling
  139. Polyphyllin II inhibits thyroid cancer cell growth by simultaneously inhibiting glycolysis and oxidative phosphorylation
  140. Relationship between the expression of copper death promoting factor SLC31A1 in papillary thyroid carcinoma and clinicopathological indicators and prognosis
  141. CSF2 polarized neutrophils and invaded renal cancer cells in vitro influence
  142. Proton pump inhibitors-induced thrombocytopenia: A systematic literature analysis of case reports
  143. The current status and influence factors of research ability among community nurses: A sequential qualitative–quantitative study
  144. OKAIN: A comprehensive oncology knowledge base for the interpretation of clinically actionable alterations
  145. The relationship between serum CA50, CA242, and SAA levels and clinical pathological characteristics and prognosis in patients with pancreatic cancer
  146. Identification and external validation of a prognostic signature based on hypoxia–glycolysis-related genes for kidney renal clear cell carcinoma
  147. Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility
  148. Relationship of resting echocardiography combined with serum micronutrients to the severity of low-gradient severe aortic stenosis
  149. Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial
  150. The diagnostic performance of machine learning-based FFRCT for coronary artery disease: A meta-analysis
  151. Comparing biofeedback device vs diaphragmatic breathing for bloating relief: A randomized controlled trial
  152. Serum uric acid to albumin ratio and C-reactive protein as predictive biomarkers for chronic total occlusion and coronary collateral circulation quality
  153. Multiple organ scoring systems for predicting in-hospital mortality of sepsis patients in the intensive care unit
  154. Single-cell RNA sequencing data analysis of the inner ear in gentamicin-treated mice via intraperitoneal injection
  155. Suppression of cathepsin B attenuates myocardial injury via limiting cardiomyocyte apoptosis
  156. Influence of sevoflurane combined with propofol anesthesia on the anesthesia effect and adverse reactions in children with acute appendicitis
  157. Review Articles
  158. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  159. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  160. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  161. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  162. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  163. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  164. The application of augmented reality in robotic general surgery: A mini-review
  165. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  166. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  167. Plant polyphenols, terpenes, and terpenoids in oral health
  168. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  169. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  170. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  171. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  172. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  173. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  174. Giant borderline ovarian tumours – review of the literature
  175. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  176. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  177. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  178. Supplement strategies for infertility in overweight women: Evidence and legal insights
  179. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  180. A meta-analysis of the effects of DBS on cognitive function in patients with advanced PD
  181. Protective role of selenium in sepsis: Mechanisms and potential therapeutic strategies
  182. Strategies for hyperkalemia management in dialysis patients: A systematic review
  183. C-reactive protein-to-albumin ratio in peripheral artery disease
  184. Case Reports
  185. Delayed graft function after renal transplantation
  186. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  187. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  188. Giant right atrial hemangioma presenting with ascites: A case report
  189. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  190. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  191. Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report
  192. Coronary artery anomalies: A case of the “malignant” left coronary artery and its surgical management
  193. Rapid Communication
  194. Biological properties of valve materials using RGD and EC
  195. A single oral administration of flavanols enhances short-term memory in mice along with increased brain-derived neurotrophic factor
  196. Letter to the Editor
  197. Role of enhanced external counterpulsation in long COVID
  198. Expression of Concern
  199. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  200. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  201. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  202. Corrigendum
  203. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  204. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  205. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  206. Retraction
  207. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  208. Retraction of: “LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through downregulating SP-A by sponging to miR-424”
  209. Retraction of: “SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways”
  210. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  211. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  212. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  213. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  214. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  215. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  216. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  217. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  218. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  219. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  220. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  221. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  222. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  223. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  224. Red cell distribution width predicts early kidney injury: A NHANES cross-sectional study
  225. Special Issue Diabetes mellitus: pathophysiology, complications & treatment
  226. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  227. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  228. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  229. A review of brain research on T2DM-related cognitive dysfunction
  230. Metformin and estrogen modulation in LABC with T2DM: A 36-month randomized trial
  231. Special Issue Innovative Biomarker Discovery and Precision Medicine in Cancer Diagnostics
  232. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
https://doi.org/10.1515/med-2025-1160
Keywords for this article
depression; CHARLS; risk factor; middle-aged and elderly people
Creative Commons
BY 4.0

Articles in the same Issue

  1. Research Articles
  2. Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
  3. Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
  4. Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
  5. Risk factors for severe adverse drug reactions in hospitalized patients
  6. Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
  7. Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
  8. CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
  9. Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
  10. Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
  11. Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
  12. Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
  13. Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
  14. Association between statin administration and outcome in patients with sepsis: A retrospective study
  15. Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
  16. A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
  17. Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
  18. Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
  19. Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
  20. Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
  21. Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
  22. The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
  23. Health literacy and health-related quality of life: The mediating role of irrational happiness
  24. Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
  25. Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
  26. Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
  27. Clinical analysis of ten cases of HIV infection combined with acute leukemia
  28. Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
  29. Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
  30. Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
  31. Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
  32. Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
  33. The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
  34. The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
  35. Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
  36. Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
  37. Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
  38. The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
  39. Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
  40. A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
  41. A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  42. Identifying early screening factors for depression in middle-aged and older adults: A cohort study
  43. Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
  44. Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
  45. High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
  46. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Investigation of the pathogenic variants induced Sjogren’s syndrome in Turkish population
  128. Nucleotide metabolic abnormalities in post-COVID-19 condition and type 2 diabetes mellitus patients and their association with endocrine dysfunction
  129. TGF-β–Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization
  130. Ultrasound-guided unilateral versus bilateral erector spinae plane block for postoperative analgesia of patients undergoing laparoscopic cholecystectomy
  131. Profiling gut microbiome dynamics in subacute thyroiditis: Implications for pathogenesis, diagnosis, and treatment
  132. Delta neutrophil index, CRP/albumin ratio, procalcitonin, immature granulocytes, and HALP score in acute appendicitis: Best performing biomarker?
  133. Anticancer activity mechanism of novelly synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative on colon cancer cells
  134. H2valdien3 arrests the cell cycle and induces apoptosis of gastric cancer
  135. Prognostic relevance of PRSS2 and its immune correlates in papillary thyroid carcinoma
  136. Association of SGLT2 inhibition with psychiatric disorders: A Mendelian randomization study
  137. Motivational interviewing for alcohol use reduction in Thai patients
  138. Luteolin alleviates oxygen-glucose deprivation/reoxygenation-induced neuron injury by regulating NLRP3/IL-1β signaling
  139. Polyphyllin II inhibits thyroid cancer cell growth by simultaneously inhibiting glycolysis and oxidative phosphorylation
  140. Relationship between the expression of copper death promoting factor SLC31A1 in papillary thyroid carcinoma and clinicopathological indicators and prognosis
  141. CSF2 polarized neutrophils and invaded renal cancer cells in vitro influence
  142. Proton pump inhibitors-induced thrombocytopenia: A systematic literature analysis of case reports
  143. The current status and influence factors of research ability among community nurses: A sequential qualitative–quantitative study
  144. OKAIN: A comprehensive oncology knowledge base for the interpretation of clinically actionable alterations
  145. The relationship between serum CA50, CA242, and SAA levels and clinical pathological characteristics and prognosis in patients with pancreatic cancer
  146. Identification and external validation of a prognostic signature based on hypoxia–glycolysis-related genes for kidney renal clear cell carcinoma
  147. Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility
  148. Relationship of resting echocardiography combined with serum micronutrients to the severity of low-gradient severe aortic stenosis
  149. Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial
  150. The diagnostic performance of machine learning-based FFRCT for coronary artery disease: A meta-analysis
  151. Comparing biofeedback device vs diaphragmatic breathing for bloating relief: A randomized controlled trial
  152. Serum uric acid to albumin ratio and C-reactive protein as predictive biomarkers for chronic total occlusion and coronary collateral circulation quality
  153. Multiple organ scoring systems for predicting in-hospital mortality of sepsis patients in the intensive care unit
  154. Single-cell RNA sequencing data analysis of the inner ear in gentamicin-treated mice via intraperitoneal injection
  155. Suppression of cathepsin B attenuates myocardial injury via limiting cardiomyocyte apoptosis
  156. Influence of sevoflurane combined with propofol anesthesia on the anesthesia effect and adverse reactions in children with acute appendicitis
  157. Review Articles
  158. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  159. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  160. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  161. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  162. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  163. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  164. The application of augmented reality in robotic general surgery: A mini-review
  165. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  166. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  167. Plant polyphenols, terpenes, and terpenoids in oral health
  168. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  169. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  170. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  171. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  172. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  173. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  174. Giant borderline ovarian tumours – review of the literature
  175. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  176. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  177. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  178. Supplement strategies for infertility in overweight women: Evidence and legal insights
  179. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  180. A meta-analysis of the effects of DBS on cognitive function in patients with advanced PD
  181. Protective role of selenium in sepsis: Mechanisms and potential therapeutic strategies
  182. Strategies for hyperkalemia management in dialysis patients: A systematic review
  183. C-reactive protein-to-albumin ratio in peripheral artery disease
  184. Case Reports
  185. Delayed graft function after renal transplantation
  186. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  187. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  188. Giant right atrial hemangioma presenting with ascites: A case report
  189. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  190. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  191. Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report
  192. Coronary artery anomalies: A case of the “malignant” left coronary artery and its surgical management
  193. Rapid Communication
  194. Biological properties of valve materials using RGD and EC
  195. A single oral administration of flavanols enhances short-term memory in mice along with increased brain-derived neurotrophic factor
  196. Letter to the Editor
  197. Role of enhanced external counterpulsation in long COVID
  198. Expression of Concern
  199. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  200. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  201. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  202. Corrigendum
  203. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  204. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  205. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  206. Retraction
  207. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  208. Retraction of: “LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through downregulating SP-A by sponging to miR-424”
  209. Retraction of: “SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways”
  210. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  211. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  212. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  213. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  214. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  215. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  216. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  217. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  218. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  219. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  220. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  221. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  222. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  223. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  224. Red cell distribution width predicts early kidney injury: A NHANES cross-sectional study
  225. Special Issue Diabetes mellitus: pathophysiology, complications & treatment
  226. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  227. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  228. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  229. A review of brain research on T2DM-related cognitive dysfunction
  230. Metformin and estrogen modulation in LABC with T2DM: A 36-month randomized trial
  231. Special Issue Innovative Biomarker Discovery and Precision Medicine in Cancer Diagnostics
  232. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
Sign up now to receive a 20% welcome discount
Institutional Access
How does access work?
Have an idea on how to improve our website?
Please write us.
© 2025 De Gruyter Brill
Downloaded on 10.12.2025 from https://www.degruyterbrill.com/document/doi/10.1515/med-2025-1160/html
Scroll to top button