Startseite Association of placenta weight and morphology with term low birth weight: A case–control study
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Association of placenta weight and morphology with term low birth weight: A case–control study

  • Jing Liu ORCID logo , Die Liu , Haixiao Liang , Qi Sun , Yuanmei Chen , Fang Ye und Qi Zhang ORCID logo EMAIL logo
Veröffentlicht/Copyright: 26. September 2025
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Open Medicine
Aus der Zeitschrift Open Medicine Band 20 Heft 1

Abstract

Background and aim

Few studies identified the role of the placenta in birth weight. We aimed to explore the connection between placenta weight, morphology, and term low birth weight (TLBW).

Methods

This was a case–control study of neonates born at ≥37 weeks’ gestation enrolled in a general hospital from January 2018 to November 2022. Cases (<2,500 g) identified via birth certificates or medical records were matched with controls on the basis of date of birth, gestational age, sex, and maternal age. A nomogram predictive model was constructed based on logistic regression, using placenta parameters and perinatal information.

Results

A total of 290 neonates (115 with diagnosed TLBW and 175 controls) were determined. There were no significant differences between the two groups concerning gestational age (265.5 ± 5.4 vs 266.3 ± 5.3 days, P = 0.1397), gender, and maternal age at delivery (32.0 ± 3.5 vs 32.1 ± 3.1 years, P = 0.867). The placenta weight (479.0 ± 80.1 vs 597.1 ± 83.1 cm), length (16.3 ± 2.1 vs 18.8 ± 2.0 cm), width (14.3 ± 2.1 vs 16.9 ± 2.0 cm), and thickness (2.3 ± 0.5 vs 2.4 ± 0.4 cm) in the TLBW group were much lower than those in the control group (all P < 0.001). Univariate predictors of TLBW included smaller placental weight, length, width, thickness, volume, and surface area. When put into a multivariate model, placental weight (aOR for per 10 g increase: 0.89; 95% CI: 0.84–0.94) and width (aOR for per 1 cm increase: 0.69; 95% CI: 0.54–0.88) remained to be independent predictors even after controlling for relevant confounders. The odds of TLBW increased when placental weight was below the 50th percentile (aOR: 5.08, 95% CI: 2.59–9.95). Placental width below the 50th percentile was significantly associated with an increased risk of TLBW (aOR: 6.57, 95% CI: 2.73–15.82).

Conclusions

Placental weight and width were found to be associated with TLBW. Further studies focusing on placental function, histology, and pathophysiology are needed to better understand the underlying mechanisms influencing fetal growth and TLBW.

Keywords: placenta weight; placenta morphology; low birth weight; term birth

1 Introduction

Birth weight, an essential indicator of fetal growth, nutrition, and placenta function, is closely related to perinatal survival and later-life health. In 2015, an estimated 20.5 million babies worldwide were born with low birth weight (LBW, <2,500 g), accounting for 14.6% of all live births [1]. According to the gestational weeks, LBW is distinguished into three categories: preterm LBW, term LBW (TLBW), and postterm LBW. About 91% of LBW infants were born in low- and middle-income countries, and the majority was predominated by TLBW [2]. It was discovered that birth weight has a far greater effect on mortality rates than gestational age [3]. Moreover, LBW has become the second leading cause of perinatal death after preterm birth. Notably, TLBW weighing 1,500–2,500 g had a perinatal mortality rate that was 5–30 times that of normal birth weight infants [3]. Growing evidence suggests that LBW raises the risk of adult disease, especially coronary heart disease, hypertension, and chronic renal disease [4,5].

Factors that may affect fetal growth are manifold and can be divided into different categories: fetal, maternal, uterine-placental, and environmental factors. Additionally, it should be highlighted that TLBW is generally accompanied with intrauterine dystrophy due to abnormal placental circulation. The placenta performs crucial physiological tasks like transport, endocrine, metabolic, and immune functions, serving as a regulatory interface between the mother and the fetus [6,7]. Fetal growth and development are critically dependent on the placental transfer capacity of nutrients, waste products, and other solutes, which is determined by several key components, such as placental size, morphology, transporter abundance and activity, maternal supply ability, and uterine-placental blood flow [8–10]. Indeed, poor placentation, including structurally damaged, abnormal development, insufficiency, dysfunction, etc., is associated with adverse pregnancy outcomes such as miscarriage, pre-eclampsia, intrauterine growth restriction (IUGR), preterm birth, and abnormal birth weight [11–14]. Therefore, it is essential to understand how the placenta develops and functions in order to identify potential targets for preventative or therapeutic interventions to promote child–maternal health.

Studies have demonstrated that the placenta structure and appearance could quantify placenta function to some extent. A reduction in placental volume and surface area, as well as increased thickness, may be markers of placental insufficiency [15]. Additionally, aberrant placental shape may be related to reduced placental efficacy [16]. The associations between placenta morphological measurements and health consequences are also identified in the current literature. Placenta weight is proportional to birth weight to the 0.75 power in term infants [17]. Reduced placenta weight, smaller surface area, or increased placenta thickness-to-volume ratio are observed in fetuses with IUGR [18–20]. Small placental size and uteroplacental malperfusion are more common in term small for gestational age (SGA) than in term appropriate for gestational age (AGA) placentas [21].

Although changes in the absolute or relative placenta size or weight do not necessarily indicate changes in placental function, morphometric measurements of the placenta can provide additional insights into aspects of fetal health and pregnancy outcomes. We hypothesize that differences in placenta development affect placenta function, which in turn influences fetal development, and that variations in placenta morphology are associated with neonatal birth weight. Therefore, we conducted this case–control study in order to fully understand the role of placenta morphological changes in the development of TLBW. In this study, we measured a set of gross morphometric parameters of the placenta, including placental weight, thickness, and inner diameter, and evaluated whether these parameters differed between singleton TLBW infants and normal birth weight infants. We also performed univariate and multivariate logistic regression analysis and drew a nomogram.

2 Methods

2.1 Study design

This case–control study collected the dataset of 10,511 singletons live births delivered in a tertiary general hospital in Beijing from January 1, 2018 to November 1, 2022. We included newborns ≥37 weeks gestational age (GA) with birth weight (BW) <4,000 g. Cases were defined as BW <2,500 g and GA ≥37 weeks with a diagnosis TLBW. We matched each TLBW case with 1.5 term normal birth weight (TNBW) controls based on gestational age, sex, date of birth, and maternal age at childbirth. One infant was excluded due to congenital heart disease and two infants were not included because they either did not receive prenatal check-ups or received care elsewhere finally leaving a final study group of 115 TLBW cases and 175 TNBW controls (Figure 1). The hospital’s Ethical Committee authorized this research. Parental informed consent was obtained in writing from each participant.

Figure 1 Flow chart of study sample selection.
Figure 1

Flow chart of study sample selection.

2.2 Newborn and maternal clinical data

The hospital’s electronic medical record system was reviewed to obtain clinical information regarding both newborns and mothers. We collected neonatal characteristics, such as gender, gestational age, birth weight, gravidity, parity, length, and head circumference. Additionally, we gathered information about each newborn’s mother, including her age at delivery, ethnicity, delivery and conception method, pre-pregnancy weight and height, gestational weight gain, maternal comorbidities, pre-existing chronic diseases, medication use during pregnancy, and any fetal appendage abnormalities. Gestational age was determined based on the last menstrual period, which was cross-checked for accuracy.

2.3 Placenta data

Measurements of placental morphological parameters were performed by trained professionals using standardized protocols. After the delivery of the placenta, fetal membranes were trimmed and the umbilical cord was removed within approximately 5 cm of insertion. The excess blood clots were washed away with normal saline, and any water stains on the surface of the placenta were wiped dry with gauze. The following were immediately measured: placental weight was measured using a standard scale with an accuracy of 1 g; the placental length diameter was measured along the longest axis, and the width diameter was measured along the axis perpendicular to the longest axis; placental thickness was measured at the thickest point, with multiple measurements taken to minimize variability and the maximum value used for analysis. The difference in diameters was calculated as the length diameter minus the width diameter. Placenta surface area and volume are calculated according to the following formula: Surface area = π/4* length diameter* width diameter; Volumes = 4/3*π* length diameter/2* width diameter/2* thickness/2; Specific surface area (Sv) = Surface area/Volume [22‒25].

The technicians responsible for weighing the placenta and those measuring the infant’s birth weight were separate individuals who did not have access to each other’s results, thereby ensuring that no measurement bias was introduced.

2.4 Statistical analyses

Mean and standard deviation (SD) were reported for continuous variables, while integers and proportions were used for categorical variables. Utilizing appropriate statistical analyses, such as the Chi-square test and the Mann–Whitney U-test, we analyzed the difference in characteristics between the TLBW and control groups. Medians and quartiles were calculated to describe the distribution of placental morphology measurements. Logistic regression analyses were carried out to examine the association of the placental morphology indices (placental weight, length, width, thickness, etc.) with TLBW. Considering the nonlinear association pattern, all the subjects enrolled were also divided into two groups according to the median of the placental morphology measurements. Univariate analysis was carried out first, followed by multivariate analysis incorporating variables with significant findings in univariate analysis. Collinearity among the variables in the multivariable model was examined using variance inflation factor (VIF), and significant collinearity variables (i.e., surface area and volume, VIF > 10) were excluded. Adjusted odds ratio (aOR) with a 95% confidence interval (CI) was estimated by adjusting for possible confounders, including gravidity, parity, maternal height, and maternal weight before delivery. A nomogram was constructed to predict TLBW probability based on our final adjusted multivariable model. A two-sided P < 0.05 was used to declare statistical significance. R software version 4.1.1 was used for all statistical analyses.

  1. Informed consent: Parental informed consent was obtained in writing from each participant.

  2. Ethical approval: This study was approved by the China–Japan Friendship Hospital ethics committee board (2023-KY-057). All methods were carried out in accordance with relevant guidelines and regulations.

3 Results

3.1 General characteristics

Tables 1 and 2 summarize the clinical features of the mothers and neonates enrolled in this study, respectively. The neonates’ gestational age (265.5 ± 5.4 vs 266.3 ± 5.3 days, P = 0.1397), gender, ethnicity, maternal age (32.0 ± 3.5 vs 32.1 ± 3.1 years, P = 0.867), method of delivery, or conception showed no significant difference between TLBW cases and TNBW group. There was a large difference in birth weight between TLBW (2327.0 ± 161.2 g) and TNBW (3081.3 ± 311.0 g) infants, with associated differences in length and head circumference (Table 1).

Table 1

Baseline characteristics of eligible neonates (n = 290)

Variables TLBW group (n = 115) TNBW group (n = 175) P value
Gestational age (days), mean ± SD 265.5 ± 5.4 266.3 ± 5.3 0.1397
Sex, n (%) 0.431
 Male 42 (36.5) 72 (41.1)
 Female 73 (63.5) 103 (58.9)
Birth weight (g), mean ± SD 2327.0 ± 161.2 3081.3 ± 311.0 <0.0001
Gravidity, mean ± SD 1.5 ± 0.8 1.8 ± 1.0 0.0201
Parity, mean ± SD 1.1 ± 0.3 1.4 ± 0.5 <0.0001
Length, mean ± SD 47.0 ± 1.6 49.8 ± 1.2 <0.0001
Head circumference, mean ± SD 32.0 ± 1.3 33.5 ± 1.3 <0.0001
Table 2

Descriptive statistics of maternal information, amniotic fluid, umbilical cord, and placenta characteristics

Variables TLBW group (n = 115) TNBW group (n = 175) P value
Maternal characteristics
Age at delivery (years), mean ± SD 32.0 ± 3.5 32.1 ± 3.1 0.867
Ethnicity, n (%) 0.174
 Han 101 (87.8) 162 (92.6)
 Others* 14 (12.2) 13 (7.4)
Delivery mode, n (%) 0.108
 Forceps delivery 5 (4.3) 5 (2.9)
 Spontaneous vaginal delivery 40 (34.8) 82 (46.9)
 Caesarean section 70 (60.9) 88 (50.3)
Conception method, n (%) 0.928
 Spontaneously conceived 110 (95.7) 167 (95.4)
 IVF-ET 5 (4.3) 8 (4.6)
Maternal height, mean ± SD 161.3 ± 5.3 163.1 ± 4.8 0.003
Maternal weight before delivery, mean ± SD 66.6 ± 10.1 70.1 ± 9.1 0.0012
Gestational weight gain (kg), mean ± SD 10.9 ± 4.5 11.6 ± 4.1 0.1867
Pre-pregnancy BMI, mean ± SD 25.6 ± 3.3 26.3 ± 3.4 0.0551
PROM, n (%) 27 (23.5) 54 (30.9) 0.171
Preeclampsia, n (%) 12 (10.4) 9 (5.1) 0.089
Gestational hypertension, n (%) 9 (7.8) 5 (2.9) 0.053
GDM, n (%) 32 (27.8) 46 (26.3) 0.772
Gestational anemia, n (%) 23 (20.0) 40 (22.9) 0.564
Pregnancy with uterine fibroids, n (%) 16 (13.9) 20 (11.4) 0.53
Pregnancy complicated hypothyroidism, n (%) 6 (5.2) 13 (7.4) 0.457
GBS (+), n (%) 2 (1.7) 5 (2.9) 0.707
Maternal chronic disease before pregnancy, n (%)
 Hypothyroidism 6 (5.2) 9 (5.1) 0.978
 Connective tissue disease 6 (5.2) 1 (0.6) 0.017
 Hashimoto thyroiditis 1 (0.9) 4 (2.3) 0.651
 Others† 6 (5.2) 11 (6.3) 0.705
Medication use in pregnancy, n (%) 20 (17.4) 31 (17.7) 0.944
 Levothyroxine 8 (7.0) 18 (10.3) 0.332
 Aspirin 5 (4.3) 4 (2.3) 0.491
 Labetalol 2 (1.7) 6 (3.4) 0.485
 Prednisone 4 (3.5) 1 (0.6) 0.083
 Others§ 2 (1.7) 5 (2.9) 0.707
Amniotic fluid characteristics
Oligohydramnios, n (%) 26 (22.6) 13 (7.4) <0.001
Meconium-stained amniotic fluid, n (%) 8 (7.0) 1 (0.6) 0.003
Umbilical cord characteristics
Umbilical cord around the neck, n (%) 35 (30.4) 52 (29.7) 0.896
Umbilical cord twist, n (%) 26 (22.6) 14 (8.0) <0.001
Umbilical cord prolapse, n (%) 4 (3.5) 2 (1.1) 0.219
True umbilical cord knot, n (%) 2 (1.7) 1 (0.6) 0.565
Placenta characteristics
Velamentous placenta, n (%) 3 (2.6) 1 (0.6) 0.304
Battledore placenta, n (%) 4 (3.5) 7 (4.0) 1
Placental abruption, n (%) 2 (1.7) 2 (1.1) 0.65
Placenta adhesion, n (%) 2 (1.7) 4 (2.3) 1
Low-lying placenta, n (%) 7 (6.1) 17 (9.7) 0.346
Placenta previa, n (%) 1 (0.9) 3 (1.7) 1

*Includes Hui, Manchu, Mongolians, and other ethnic minorities.

†Includes hyperthyroidism, asthma, nephritis, epilepsy, and others.

§Includes insulin, inhaled corticosteroids, and others.

IVF-ET, in vitro fertilization and embryo transfer; BMI, body mass index; PROM, premature rupture of membranes; GDM, gestational diabetes mellitus; GBS, group B streptococcus.

We observed that both the maternal weight and weight before delivery were significantly lower in the TLBW group (P < 0.05), while gestational weight gain and pre-pregnancy body mass index (BMI) did not show significant differences between the two groups (Table 2). Pregnancy complications (such as premature rupture of membranes (PROM), preeclampsia, gestational diabetes mellitus [GDM], hypertension, anemia, uterine fibroids, and hypothyroidism), some maternal chronic disease before pregnancy (including hypothyroidism and Hashimoto thyroiditis), and medication use in pregnancy (for example, levothyroxine, aspirin, labetalol, and prednisone) did not significantly differ (P > 0.05). The TLBW group had a higher incidence of oligohydramnios, meconium-stained amniotic fluid, and umbilical cord twist (P < 0.05). However, no significant differences were seen between the two groups with regard to the incidence of umbilical cord around the neck or prolapse, velamentous or battledore placenta, placental abruption or adhesion, etc. (P > 0.05).

The mean, interquartile range values of the placental morphology measurements are shown in Table S1. The placenta weight (479.0 ± 80.1 vs 597.1 ± 83.1 cm), length (16.3 ± 2.1 vs 18.8 ± 2.0 cm), width (14.3 ± 2.1 vs 16.9 ± 2.0 cm), and thickness (2.3 ± 0.5 vs 2.4 ± 0.4 cm) in the TLBW group were much lower than those in the control group (all P < 0.001).

3.2 Placental weight and width are associated with TLBW

Univariate predictors of TLBW included placental weight, length, width, thickness, volume, surface area, and specific surface area. Among these, smaller placental weight, length, width, thickness, volume, and surface area were identified as associated with TLBW, while smaller specific surface area was found to be associated with a lower risk of TLBW (Figure 2). Placental weight (aOR for per 10 g increase: 0.89; 95% CI: 0.84–0.94) and width (aOR for per 1 cm increase: 0.69; 95% CI: 0.54–0.88) remained to be independent predictors even after controlling for relevant confounders in the final multivariate regression model (Figure 2).

Figure 2 Forest plots of univariate and multivariate logistic regression analysis results of continuous placental morphology measurements.
Figure 2

Forest plots of univariate and multivariate logistic regression analysis results of continuous placental morphology measurements.

The results were consistent when these morphometric parameters were analyzed as categorical variables (Figure 3). We observed that the odds of TLBW were higher when placental weight was below the 50th percentile (aOR: 5.08, 95% CI: 2.59–9.95) in the multivariate model. Similarly, placental width below the 50th percentile was significantly associated with an increased risk of TLBW (aOR: 6.57, 95% CI: 2.73–15.82).

Figure 3 Forest plots of univariate and multivariate logistic regression analysis results of categorical placental morphology measurements.
Figure 3

Forest plots of univariate and multivariate logistic regression analysis results of categorical placental morphology measurements.

A nomogram was developed to predict the probability of TLBW based on the two independent parameters of placental weight and width (Figure 4). Each predictor is given a score on the point scale axis based on its value, and the total score is calculated by adding each individual score. The predicted TLBW risk can be determined by projecting the total score line straight to the probability scale line at the bottom. The calibration plots indicated a high level of agreement between the prediction model and the actual results (Figure 5). To further evaluate the performance of the prediction model, a receiver operating characteristic (ROC) curve was plotted (Figure 6). The area under the curve was 0.905 (95% CI: 0.87–0.939), suggesting that the model has good discriminatory ability.

Figure 4 Nomogram for TLBW.
Figure 4

Nomogram for TLBW.

Figure 5 Calibration curves for the nomogram.
Figure 5

Calibration curves for the nomogram.

Figure 6 ROC curve of the nomogram.
Figure 6

ROC curve of the nomogram.

4 Discussion

The size, shape, and structure of the placenta are crucial factors for healthy fetal development. There is ongoing research and debate about the relationship between placental morphological changes and adverse pregnancy outcomes. Our case–control matched design study included around 300 term singleton livebirths delivered in a tertiary general hospital. To our knowledge, this study is one of the largest sample size studies conducted to date, and has employed statistical methods such as univariate and multivariate logistic regression to identify predictors of TLBW. We observed that placental weight and width were associated with increased risk of TLBW. The risk of TLBW decreased by 11 and 31% for every 10 g increase in placental weight and 1 cm increase in width diameter, respectively. Neonates with a placental weight less than 550 g had a 5.08-fold higher risk of TLBW compared to those with a placental weight greater than 550 g. Placental width diameter ≤16 cm showed a 6.57-fold of TLBW compared with those with longer width (more than 16 cm).

In the present study, we identified significant differences in placental weight between the TLBW and control groups. Similar findings were reported in previous studies, including one by Zheng et al., which found a significant difference in placental weight between TLBW and TNBW infants, with the TLBW group having a significantly lower placental weight (492.8 ± 38.5 g) compared to the TNBW group (701.2 ± 106.7 g) [26]. In addition, a study in India demonstrated that preterm LBW had lower mean placental weight than TLBW infants (410.2 g ± 101.3 vs 469.1 ± 55.8 g) [27]. Similar results were found in SGA and neonates with IUGR. Biswas and Ghosh reported a mean placental weight of 333.32 ± 75.59 g for the IUGR group and 416.77 ± 63.03 g for the control group [18]. Chisholm and Folkins observed that the mean placental weight of term SGA group was 351.85 ± 139.28 g and that of AGA group was 445.90 ± 86.33 g [21].

More importantly, our logistic regression analysis further confirmed that placental weight was an independent predictive factor of TLBW. There was a significant relationship between placental weight and TLBW whether treated as a continuous or categorical variable. Many studies have shown that there is a positive correlation between placental weight and birth weight. For example, the prospective study conducted in Mexico found that for each 1 g increase in placental weight, there was a corresponding increase of approximately 1.98 g in birth weight among term newborns [28]. Similarly, placenta weight percentile curves according to gestational weight for singleton and twins deliveries in Canadian population fit by appearance positive linear relations [29]. These findings suggest that placental weight may play an important role in fetal growth and development, as well as serve as an indicator of efficacy in nutrient and oxygen transport. Additionally, the ratio of birth weight to placental weight has been proposed as a marker of placental efficiency [30–32].

Decreased placental width diameter was another predictor of TLBW in this study. Although length, thickness, volume, surface area, and specific surface area were significant on univariate analysis, they failed to confirm the multivariate importance. Haeussner et al. found that the shape of the placental disc converges toward a roundish, but not precisely circular [33]. Lower birth weight was observed in non-round/oval placentas [34]. The difference in length and width reflects the degree of ovality of the placenta. In this study, however, the difference in diameters between the two groups was not significant. We speculate that differences in placental shape may represent an adaptation to the unique environmental conditions experienced by each fetus, which may differ from placental weight.

Indeed, in addition to placental weight and gross morphological parameters, placental parameters measured by ultrasound, such as placental volume, thickness, and vascularity, have been shown to correlate with fetal growth. A prospective study of 619 Chinese women with singleton pregnancy revealed that placental volume in early pregnancy was an independent predictor of SGA [35]. Studies have demonstrate that placental evaluation using three-dimensional ultrasonographic placental measurements at 11–14 weeks of gestation can significantly improve the early prediction of SGA [36,37]. However, there is currently no standardized method for assessing antepartum placental growth during pregnancy. Additionally, the additional time required for 3D measurements compared to 2D measurements, the lack of machines capable of multiplanar reconstruction, and the lack of a universal reference range for placental measurements are some of the limitations that must be addressed for ultrasound measurement of the placenta to become a standard diagnostic tool.

Overall, this study has several strengths, including a sufficient sample size and the use of reproducible and reliable measurement indicators for the general parameters of the placenta. Furthermore, we identified two important predictors (placental weight and placental width) that are important parameters for prediction of TLBW. We also controlled for confounding factors such as gestational age, mother’s height, and weight before delivery, which strengthens the validity of our results. However, there were several limitations. First, we only measured placental morphology at delivery, and future studies that include parameters related to placental structure and function during pregnancy may offer more valuable insights. Second, this study was conducted at a single center, which may limit the generalizability of our results. Multicentric validation could enhance the external applicability of our findings. Third, although matching was performed on key variables, other important determinants of fetal growth were not accounted for a priori, and residual confounding remains possible despite post hoc adjustment.

5 Conclusions

In conclusion, it appears that the placentas in the TLBW group were generally smaller than those in the TNBW group, as evidenced by differences in weight, length, width, thickness, volume, and surface area. We identified placental weight and width as independent predictors of TLBW, indicating that both placental weight and size or shape may be linked to fetal growth. However, as this study is observational, further research is needed to better understand the underlying mechanisms and to explore effective strategies for monitoring placental health during pregnancy. Future studies should also include antepartum imaging or biomarkers to enhance prenatal prediction and assess the clinical applicability of these findings.

Acknowledgments

The authors thank all the participants in this study.

  1. Funding information: This work was funded by National High Level Hospital Clinical Research Funding (2022-NHLHCRF-LX-01-0301) and the Clinical research project of Beijing research ward construction (2022-YJXBF-04-01-03).

  2. Author contributions: Conception and design: L.J. and Z.Q.; administrative support: Z.Q.; provision of study materials or patients: L.H.X. and Y.F.; collection and assembly of data: L.D. and C.Y.M.; data analysis and interpretation: L.J. and S.Q.; manuscript writing: L.J. and Z.Q.; final approval of manuscript: all authors.

  3. Conflict of interest: The authors state no conflict of interest.

  4. Data availability statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Received: 2025-06-27
Revised: 2025-06-27
Accepted: 2025-07-15
Published Online: 2025-09-26

© 2025 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Artikel in diesem Heft

  1. Research Articles
  2. Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
  3. Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
  4. Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
  5. Risk factors for severe adverse drug reactions in hospitalized patients
  6. Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
  7. Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
  8. CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
  9. Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
  10. Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
  11. Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
  12. Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
  13. Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
  14. Association between statin administration and outcome in patients with sepsis: A retrospective study
  15. Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
  16. A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
  17. Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
  18. Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
  19. Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
  20. Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
  21. Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
  22. The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
  23. Health literacy and health-related quality of life: The mediating role of irrational happiness
  24. Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
  25. Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
  26. Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
  27. Clinical analysis of ten cases of HIV infection combined with acute leukemia
  28. Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
  29. Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
  30. Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
  31. Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
  32. Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
  33. The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
  34. The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
  35. Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
  36. Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
  37. Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
  38. The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
  39. Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
  40. A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
  41. A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  42. Identifying early screening factors for depression in middle-aged and older adults: A cohort study
  43. Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
  44. Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
  45. High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
  46. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Review Articles
  128. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  129. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  130. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  131. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  132. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  133. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  134. The application of augmented reality in robotic general surgery: A mini-review
  135. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  136. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  137. Plant polyphenols, terpenes, and terpenoids in oral health
  138. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  139. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  140. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  141. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  142. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  143. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  144. Giant borderline ovarian tumours – review of the literature
  145. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  146. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  147. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  148. Supplement strategies for infertility in overweight women: Evidence and legal insights
  149. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  150. Case Reports
  151. Delayed graft function after renal transplantation
  152. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  153. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  154. Giant right atrial hemangioma presenting with ascites: A case report
  155. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  156. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  157. Rapid Communication
  158. Biological properties of valve materials using RGD and EC
  159. Letter to the Editor
  160. Role of enhanced external counterpulsation in long COVID
  161. Expression of Concern
  162. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  163. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  164. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  165. Corrigendum
  166. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  167. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  168. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  169. Retraction
  170. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  171. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  172. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  173. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  174. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  175. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  176. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  177. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  178. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  179. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  180. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  181. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  182. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  183. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  184. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  185. Special Issue Diabetes
  186. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  187. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  188. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  189. A review of brain research on T2DM-related cognitive dysfunction
  190. Special Issue Biomarker Discovery and Precision Medicine
  191. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
https://doi.org/10.1515/med-2025-1264
Schlagwörter für diesen Artikel
placenta weight; placenta morphology; low birth weight; term birth
Creative Commons
BY 4.0

Artikel in diesem Heft

  1. Research Articles
  2. Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
  3. Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
  4. Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
  5. Risk factors for severe adverse drug reactions in hospitalized patients
  6. Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
  7. Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
  8. CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
  9. Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
  10. Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
  11. Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
  12. Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
  13. Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
  14. Association between statin administration and outcome in patients with sepsis: A retrospective study
  15. Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
  16. A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
  17. Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
  18. Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
  19. Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
  20. Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
  21. Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
  22. The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
  23. Health literacy and health-related quality of life: The mediating role of irrational happiness
  24. Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
  25. Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
  26. Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
  27. Clinical analysis of ten cases of HIV infection combined with acute leukemia
  28. Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
  29. Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
  30. Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
  31. Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
  32. Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
  33. The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
  34. The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
  35. Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
  36. Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
  37. Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
  38. The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
  39. Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
  40. A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
  41. A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  42. Identifying early screening factors for depression in middle-aged and older adults: A cohort study
  43. Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
  44. Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
  45. High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
  46. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Review Articles
  128. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  129. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  130. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  131. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  132. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  133. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  134. The application of augmented reality in robotic general surgery: A mini-review
  135. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  136. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  137. Plant polyphenols, terpenes, and terpenoids in oral health
  138. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  139. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  140. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  141. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  142. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  143. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  144. Giant borderline ovarian tumours – review of the literature
  145. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  146. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  147. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  148. Supplement strategies for infertility in overweight women: Evidence and legal insights
  149. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  150. Case Reports
  151. Delayed graft function after renal transplantation
  152. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  153. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  154. Giant right atrial hemangioma presenting with ascites: A case report
  155. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  156. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  157. Rapid Communication
  158. Biological properties of valve materials using RGD and EC
  159. Letter to the Editor
  160. Role of enhanced external counterpulsation in long COVID
  161. Expression of Concern
  162. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  163. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  164. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  165. Corrigendum
  166. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  167. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  168. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  169. Retraction
  170. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  171. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  172. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  173. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  174. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  175. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  176. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  177. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  178. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  179. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  180. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  181. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  182. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  183. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  184. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  185. Special Issue Diabetes
  186. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  187. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  188. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  189. A review of brain research on T2DM-related cognitive dysfunction
  190. Special Issue Biomarker Discovery and Precision Medicine
  191. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
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Heruntergeladen am 30.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/med-2025-1264/html
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