Startseite Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
Artikel Open Access

Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis

  • Nedim Uzun EMAIL logo , Ozgecan Gundogar , Naile Misirlioglu , Emine Yildirim , Neslin Sahin , Seyma Dumur und Hafize Uzun
Veröffentlicht/Copyright: 24. Juli 2025
Artikel downloaden (PDF)
Open Medicine
Aus der Zeitschrift Open Medicine Band 20 Heft 1

Abstract

Objectives

Accurate diagnosis of acute cholecystitis (AC) is critical because early laparoscopic cholecystectomy significantly reduces complications and mortality. This study evaluates the predictive value of inflammatory indices and hematological markers in diagnosing AC.

Methods

A retrospective review was performed on early laparoscopic cholecystectomy cases at the Gaziosmanpaşa Training and Research Hospital in Istanbul between August 2013 and August 2023. Patient demographics, preoperative laboratory values, inflammatory indices – including neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) – were evaluated, along with hospital length of stay and histopathological outcomes.

Results

Among 249 patients, 34 (13.6%) were diagnosed with AC, comprising 76 males (30.5%) and 173 females (69.5%), with a mean age of 48.9 ± 14.6 years. The median hospital length of stay was 3 days (range: 1–21). Significant elevations in both the SIRI and neutrophil count were observed in AC cases compared to controls (P < 0.001). ROC (receiver operating characteristic) curve analysis demonstrated comparable diagnostic performance for the SIRI (AUC = 0.746; 95% CI: 0.658–0.835; optimal cutoff: 1.98) and neutrophil count (AUC = 0.746; 95% CI: 0.658–0.835; optimal cutoff: 7.1 × 103/μL) in predicting AC.

Conclusions

The SIRI and neutrophil count are reliable markers that can improve the diagnostic accuracy and guide early management of AC.

Keywords: acute cholecystitis; diagnosis; neutrophils; systemic immune-inflammation index; systemic inflammatory response index

1 Introduction

Acute cholecystitis (AC) predominantly results from gallstone-induced obstruction of the cystic duct or gallbladder neck, a pathology affecting 10–15% of the adult population worldwide [1]. While only 30% of the gallstone carriers develop symptoms, AC represents 3–10% of the emergency department presentations for acute abdominal pain [2,3,4].

Early surgical intervention is critical for managing AC, with laparoscopic cholecystectomy recommended within the first 72 h of presentation [5,6]. This approach has been associated with improved patient satisfaction, reduced complication rates, shorter hospital stays, and decreased mortality [7].

The Tokyo Guidelines (TG18/TG13) advocate a comprehensive diagnostic approach integrating clinical signs, biochemical markers, and imaging characteristics for AC diagnosis [8]. However, studies evaluating the diagnostic efficacy of the TG13 criteria are limited [9,10]. The reported diagnostic accuracy ranges from 60.4 to 94.0%, depending on whether pathological samples are used as the gold standard [9,11].

Recent studies have investigated the utility of inflammatory indices such as the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), aggregate index of systemic inflammation (AISI), and systemic inflammation response index (SIRI) in differentiating AC and predicting its severity [12,13,14,15,16,17,18,19]. However, most research has focused on evaluating the severity and complications of AC, with limited evidence regarding their role in pathological diagnosis.

Berhuni et al. reported that elevated SII values are significantly associated with complicated acute appendicitis, supporting their utility in early risk assessment [20]. In addition, Tiwari et al. demonstrated that both the SII and SIRI are independently associated with disease severity and the risk of acute kidney injury [21]. Furthermore, Aktimur et al. found that elevated NLR levels have diagnostic value in acute mesenteric ischemia, correlating with adverse clinical outcomes [22]. These findings highlight the broader applicability of inflammatory indices in the diagnosis and prognostic evaluation of acute abdominal emergencies.

Therefore, this study aims to evaluate the predictive value of inflammatory indices and conventional laboratory markers in the diagnosis of AC.

2 Materials and methods

2.1 Study design and setting

This retrospective cohort study included all consecutive patients who underwent emergency laparoscopic cholecystectomy at the Gaziosmanpaşa Training and Research Hospital in Istanbul between August 2013 and August 2023. The study was approved by the Institutional Review Board (Approval Date: June 2023, Reference No: 122) and conducted in accordance with the principles outlined in the Declaration of Helsinki [23].

2.2 Patient selection

Eligible participants were defined as consecutive patients aged ≥17 years presenting with AC in the emergency department who subsequently underwent laparoscopic cholecystectomy within 72 h of admission. Exclusion criteria consisted of: (1) acalculous cholecystitis, (2) concurrent cholangitis or pancreatitis, (3) chronic inflammatory disorders known to affect acute-phase reactants (e.g., rheumatoid arthritis, inflammatory bowel disease), (4) current pregnancy or lactation status, and (5) active malignancy or recent chemotherapy exposure. The complete patient selection methodology, including enrollment flow and final group stratification based on histopathological confirmation of AC versus alternative diagnoses, is detailed in Figure 1.

Figure 1 Flowchart of patient selection and grouping.
Figure 1

Flowchart of patient selection and grouping.

2.3 Data collection and inflammatory indices

A comprehensive review of both electronic medical records and archived paper documentation was conducted. Systematic data extraction included demographic characteristics, admission laboratory values (complete blood count and conventional inflammatory markers), duration of hospitalization, and final histopathological reports.

The inflammatory indices were calculated as follows:

  1. NLR = neutrophils/lymphocytes.

  2. SII = (neutrophils × platelets)/lymphocytes.

  3. SIRI = (monocytes × platelets)/lymphocytes.

  4. AISI = (neutrophils × monocytes × platelets)/lymphocytes.

Final patient stratification was based on comprehensive histopathological examination of surgical specimens, with cases categorized as either AC (demonstrating characteristic neutrophilic infiltration, mural necrosis, and other diagnostic histological features) or non-AC (encompassing chronic cholecystitis with lymphocytic infiltration and fibrosis, or simple cholelithiasis without significant inflammatory changes).

2.4 Surgical procedure and surgeon experience

All procedures were performed using a standardized laparoscopic cholecystectomy protocol employing a four-port technique under general anesthesia. The operative technique systematically included: (1) careful dissection of Calot’s triangle with identification of critical anatomical structures, (2) double clipping and division of both the cystic duct and cystic artery, and (3) meticulous gallbladder dissection from the hepatic bed. Intraoperative decisions regarding peritoneal irrigation and closed suction drainage placement were made based on the presence of significant inflammation, bile spillage, or hemorrhage. All surgical interventions were conducted by or under the direct supervision of fellowship-trained general surgeons possessing board certification and a minimum of 5 years of specialized experience in advanced laparoscopic procedures. This standardized surgical approach was rigorously maintained throughout the study period to minimize technical variability and ensure consistent operative quality.

2.5 Statistical analysis

Statistical analyses were performed using SPSS software (version 18.0, SPSS Inc., Chicago, IL, USA). Normality of continuous variables was assessed using the Shapiro–Wilk test. Continuous data were presented as mean ± standard deviation (SD) or median with interquartile range (IQR), depending on the distribution. Categorical variables were summarized as frequencies and percentages. Between-group comparisons were conducted using independent samples t-tests or Mann–Whitney U tests for continuous variables and chi-square or Fisher’s exact tests for categorical variables. Correlations were analyzed using Spearman’s correlation coefficients.

Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic accuracy of variables for AC. Optimal cutoff points were determined using Youden’s index and the maximum AUC. Sensitivity and specificity values were calculated for these cutoff points. A P-value of <0.05 was considered statistically significant.

3 Results

Out of the 567 patients evaluated in this study, 318 were excluded for the following reasons: failure to undergo surgery within the first 72 h (n = 132), incomplete data (n = 122), acalculous cholecystitis (n = 18), concomitant cholangitis or pancreatitis (n = 23), and cases involving pregnancy or oncology (n = 23). Consequently, 249 patients were included in the final analysis, of whom 76 (30.5%) were male and 173 (69.5%) were female. The mean patient age was 48.9 ± 14.6 years, and the median hospital length of stay was 3 days (range: 1–21 days).

Histopathological examination confirmed AC in 34 patients (13.6%), while the remaining 215 (86.4%) exhibited non-AC. The demographic, clinical, and laboratory characteristics of both groups are detailed in Table 1. Notably, gallbladder wall thickness and length of hospital stay were significantly greater in the AC group (P < 0.05). Furthermore, male sex was associated with an elevated risk of AC compared to females (relative risk [RR]: 1.96; 95% confidence interval [CI]: 1.33–2.89).

Table 1

Demographic and clinical characteristics of patients with and without AC

Variable AC Non-AC P-value
N = 34 N = 215
Demographics
Age (years) 50.5 (40.5–59.5) 48.0 (39.0–59.0) 0.716
Male, n (%) 18 (52.9%) 58 (27.0%) 0.002
Clinical outcomes
Length of hospital stay (days) 3.98 (3.06–5.03) 2.59 (1.94–3.68) <0.001
Pathological wall thickness (mm) 0.60 (0.40–0.70) 0.20 (0.20–0.30) <0.001
Laboratory parameters
Platelet count (109/L) 246 (202–292) 238 (196–284) 0.778
MPV (fL) 9.1 (8.4–9.6) 9.3 (8.7–9.8) 0.430
WBC count (109/L) 12.3 (10.6–14.2) 8.86 (7.22–11.2) <0.001
Lymphocyte count (109/L) 1.58 (1.10–2.15) 1.90 (1.40–2.54) 0.014
Monocyte count (109/L) 0.59 (0.45–0.72) 0.49 (0.39–0.61) 0.010
Neutrophil count (109/L) 9.91 (7.42–12.2) 5.92 (4.47–8.52) <0.001
CRP (mg/L) 24.2 (10.3–94.6) 13.3 (6.47–28.1) 0.003
Inflammatory indices
NLR 6.39 (3.91–10.41) 3.20 (1.83–6.01) <0.001
SII 1607.15 (862.19–2331.06) 733.60 (430.20–1378.82) <0.001
SIRI 3.78 (2.38–6.05) 1.55 (0.86–3.03) <0.001
AISI 1610.12 (864.48–2335.18) 735.13 (431.18–1381.86) <0.001

WBC (white blood cell count), CRP (C-reactive protein level), and MPV (mean platelet volume) are laboratory parameters. NLR (neutrophil-to-lymphocyte ratio), SII (systemic immune-inflammation index, calculated as platelet count × neutrophil count/lymphocyte count), SIRI (systemic inflammatory response index, calculated as neutrophil count × monocyte count/lymphocyte count), and AISI (aggregate inflammatory severity index) are inflammatory indices. Statistical significance was defined as P < 0.05. Data are presented as mean ± SD or median (25th–75th percentiles) as appropriate.

Significant differences in laboratory parameters between the AC and non-AC groups were observed for white blood cell (WBC) count, lymphocyte count, monocyte count, neutrophil count, and C-reactive protein (CRP) levels (P < 0.05). The SIRI, NLR, SII, and AISI were also significantly elevated in the AC group (P < 0.05).

ROC curve analysis was conducted to evaluate the predictive accuracy of inflammatory indices and laboratory markers for AC (Table 2, Figure 2). SIRI showed the strongest predictive value among the indices, with an area under the curve (AUC) of 0.749 (95% CI: 0.663–0.834). At the optimal cutoff of 1.98, SIRI demonstrated 79% sensitivity and 61% specificity. Among laboratory markers, neutrophil count had the highest AUC value of 0.746 (95% CI: 0.658–0.835), with a cutoff value of 7.1 × 109/L, yielding a sensitivity of 77% and a specificity of 63%.

Table 2

ROC curve analysis of hematologic parameters for AC

Parameter AUC SD 95% CI Cutoff Sensitivity (%) Specificity (%) P-value
SIRI 0.749 0.044 0.663–0.834 1.98 79 61 <0.001
NE 0.746 0.045 0.658–0.835 7.1 77 63 <0.001
WBC 0.736 0.006 0.723–0.748 9.7 80 60 <0.001
NLR 0.716 0.006 0.628–0.805 4.1 74 63 <0.001
AISI 0.716 0.046 0.626–0.805 963.9 71 64 <0.001
SII 0.715 0.046 0.625–0.805 964.8 71 65 <0.001
CRP 0.655 0.053 0.553–0.758 17.1 65 62 <0.001

AUC: area under the curve, SD: standard deviation, CI: confidence interval, WBC: white blood cell count, NE: neutrophil count, CRP: C-reactive protein, NLR: neutrophil-to-lymphocyte ratio, SII: systemic inflammatory index, SIRI: systemic inflammatory response index, and AISI: aggregate inflammatory systemic index. Significant values are presented in bold.

Figure 2 Receiver-operating characteristic curve analysis for predicting AC.
Figure 2

Receiver-operating characteristic curve analysis for predicting AC.

Neutrophil count exhibited strong correlations with WBC (r = 0.941; P < 0.001) and CRP (r = 0.507; P < 0.01). Additionally, significant correlations were observed between the inflammatory indices. Specifically, SIRI showed strong correlations with NLR (r = 0.905; P < 0.001), AISI (r = 0.877; P < 0.001), and SII (r = 0.876; P < 0.01).

4 Discussion

This study found that the SIRI and neutrophil count were significantly elevated in patients with AC compared to controls. ROC curve analysis identified optimal cutoff values of >1.98 for SIRI and >7.1 × 109/L for neutrophil count, which effectively predicted AC with sensitivities of 79 and 77%, respectively.

Previous studies have reported that the sensitivity of WBC count for diagnosing gangrenous cholecystitis ranges from 60 to 77% [24,25]. Similarly, the diagnostic value of CRP has been highlighted, with sensitivities reported from 71 to 100% [12,26,27,28]. In contrast to previous studies relying on clinical and radiological criteria, the present study utilized histopathological evaluation as the gold standard for definitive diagnosis. Our results revealed that WBC count exhibited superior sensitivity in distinguishing AC from non-acute cases compared to previous reports.

In this study, consistent with the findings reported by Naidu et al., neutrophil count emerged as an independent predictor of AC, with close cutoff values observed in both studies [11]. The use of histopathology as the gold standard may explain the agreement in cutoff values.

Inflammatory indices, including SIRI, NLR, SII, and AISI, have been extensively investigated as predictors of AC severity or conversion to open cholecystectomy [12,13,14,15,16,17,18,19,20,21,22]. However, to our knowledge, this study evaluated the utility of SIRI and AISI in the pathological diagnosis of AC. Additionally, SIRI demonstrated strong correlations with other indices, such as NLR, SII, and AISI, reinforcing its potential reliability as a diagnostic marker.

In addition to AC, the diagnostic utility of hematologic markers has been explored in various abdominal emergencies. Yazar et al. reported that elevated NLR and PLR values could predict the need for surgical intervention in small bowel obstruction [29]. Similarly, in acute diverticulitis, Özdemir et al. observed significantly higher NLR levels in patients with complicated disease, highlighting its role in early risk stratification [30]. Furthermore, Şahin et al. demonstrated markedly elevated SII and SIRI levels in patients with incarcerated inguinal hernia, indicating potential tissue ischemia [31]. Collectively, these findings emphasize the broader applicability of systemic inflammatory indices in the early evaluation of acute surgical pathologies – a conclusion further supported by the present study.

This study had several limitations. The retrospective and single-center design may limit the generalizability of the findings to broader patient populations. Additionally, the study lacked comprehensive data on medical history, physical examination findings, and imaging results. The imbalance in group distributions and the exclusion of certain patients may have introduced selection bias. Furthermore, subgroup analysis within AC was not performed. Comparing subgroups could have enhanced the study’s clinical relevance. Despite these limitations, this study is one of the few investigations utilizing histopathology as the gold standard for diagnosing AC. Future multicenter prospective studies are needed to validate these findings.

5 Conclusions

In conclusion, this study identified the SIRI and neutrophil count as valuable predictors of AC in emergency department settings. The SIRI >1.98 and neutrophil count >7.1 × 109/L could serve as reliable markers for the management of suspected AC cases. Large-scale prospective multicenter studies are warranted to validate these findings and enhance the diagnostic accuracy for AC.

  1. Funding information: There are no funding sources for this case report.

  2. Author contributions: NU: manuscript preparation. NU and EY: study design of the research. HU and NM: manuscript revision. OG: evaluation of pathological samples. NS and SD: data cleaning and preparation. All authors participated in drafting and revision of the manuscript. All authors have read and approved the final manuscript.

  3. Conflict of interest: The authors declare that they have no conflict of interest.

  4. Data availability statement: The data supporting the findings of this study are available within the article and its supplementary materials. Additional data related to the study can be requested from the corresponding author upon reasonable request.

References

[1] Pisano M, Allievi N, Gurusamy K, Borzellino G, Cimbanassi S, Boerna D, et al. 2020 World Society of Emergency Surgery updated guidelines for the diagnosis and treatment of acute calculus cholecystitis. World J Emerg Surg. 2020;15:1–26. 10.1186/s13017-020-00313-8.Suche in Google Scholar

[2] Fu Y, Pang L, Dai W, Wu S, Kong J. Advances in the study of acute acalculous cholecystitis: A comprehensive review. Dig Dis. 2021;40(4):468–78. 10.1159/000520025.Suche in Google Scholar PubMed

[3] Jain A, Mehta N, Secko M, Schechter J, Papanagnou D, Pandya S, et al. History, physical examination, laboratory testing, and emergency department ultrasonography for the diagnosis of acute cholecystitis. Acad Emerg Med. 2017;24(3):281–97. 10.1111/acem.13109.Suche in Google Scholar PubMed

[4] Huang S. Diagnostic performance of ultrasound in acute cholecystitis: A systematic review and meta-analysis. World J Emerg Surg. 2023;18(1):1–12. 10.1186/s13017-023-00524-5.Suche in Google Scholar PubMed PubMed Central

[5] Gutt CN, Encke J, Köninger J, Harnoss JC, Weigand K, Kipfmüller K, et al. Acute cholecystitis: Early versus delayed cholecystectomy, a multicenter randomized trial (ACDC study, NCT00447304). Ann Surg. 2013;258(3):385–93. 10.1097/SLA.0b013e3182a1599b.Suche in Google Scholar PubMed

[6] Cao AM, Eslick GD, Cox MR. Early laparoscopic cholecystectomy is superior to delayed acute cholecystitis: A meta-analysis of case–control studies. Surg Endosc. 2016;30(4):1172–82. 10.1007/s00464-015-4314-3.Suche in Google Scholar

[7] Siddiqui T, MacDonald A, Chong PS, Jenkins JT. Early versus delayed laparoscopic cholecystectomy for acute cholecystitis: A meta-analysis of randomized clinical trials. Am J Surg. 2008;195(1):40–7. 10.1016/j.amjsurg.2007.02.045.Suche in Google Scholar

[8] Yokoe M, Hata J, Takada T, Strasberg SM, Asbun HJ, Wakabayashi G, et al. Tokyo Guidelines 2018: Diagnostic criteria and severity grading of acute cholecystitis (with videos). J Hepatobiliary Pancreat Sci. 2018;25(1):41–54. 10.1002/jhbp.515.Suche in Google Scholar PubMed

[9] Yokoe M, Takada T, Strasberg SM, Solomkin JS, Mayumi T, Gomi H, et al. New diagnostic criteria and severity assessment of acute cholecystitis in revised Tokyo Guidelines. J Hepatobiliary Pancreat Sci. 2012;19(5):578–85. 10.1007/s00534-012-0548-0.Suche in Google Scholar PubMed PubMed Central

[10] Hayasaki A, Takahashi K, Fujii T, Kumamoto K, Fujii K, Matsumoto E, et al. Factor analysis influencing postoperative hospital stay and medical costs for patients with definite, suspected, or unmatched diagnosis of acute cholecystitis according to the Tokyo Guidelines 2013. Gastroenterol Res Pract. 2016;2016:7675953. 10.1155/2016/7675953.Suche in Google Scholar PubMed PubMed Central

[11] Naidu K, Beenen E, Gananadha S, Mosse C. The yield of fever, inflammatory markers and ultrasound in the diagnosis of acute cholecystitis: A validation of the 2013 Tokyo guidelines. World J Surg. 2016;40(12):2892–7. 10.1007/s00268-016-3660-5.Suche in Google Scholar PubMed

[12] Mahmood F, Akingboye A, Malam Y, Thakkar M, Jambulingam P. Complicated acute cholecystitis: The role of C-reactive protein and neutrophil-lymphocyte ratio as predictive markers of severity. Cureus. 2021;13(2):e13592. 10.7759/cureus.13117.Suche in Google Scholar PubMed PubMed Central

[13] Beliaev AM, Angelo N, Booth M, Bergin C. Evaluation of neutrophil-to-lymphocyte ratio as a potential biomarker for acute cholecystitis. J Surg Res. 2017;209:93–101. 10.1016/j.jss.2016.10.024.Suche in Google Scholar PubMed

[14] Lee SJ, Park EJ, Lee KJ, Cha YS. The delta neutrophil index is an early predictive marker of severe acute cholecystitis. Dig Liver Dis. 2019;51(11):1593–8. 10.1016/j.dld.2019.06.003.Suche in Google Scholar PubMed

[15] Özdemir S, Altunok İ, Abuzer Ö, İslam MM, Algın A, Eroğlu SE, et al. The role of the hematological inflammatory index and systemic immuno-inflammation index in acute cholecystitis. Eur J Clin Exp Med. 2022;20(3):330–5. 10.15584/ejcem.2022.3.11.Suche in Google Scholar

[16] Şener K, Çakır A, Kılavuz H, Doğan S, Güven R, Korkut S. Diagnostic value of the systemic immune-inflammation index in diagnosing acute cholecystitis. Compr Med. 2021;15(2):125–31. 10.1177/10732748211033746.Suche in Google Scholar PubMed PubMed Central

[17] Cakcak İE, Kula O. Predictive evaluation of SIRI, SII, PNI, and GPS in cholecystostomy application in patients with acute cholecystitis. Turk J Trauma Emerg Surg. 2022;28(7):940. 10.14744/tjtes.2022.90249.Suche in Google Scholar PubMed PubMed Central

[18] Gedik MS, Kilci AI, Hakkoymaz H, Seyithanoğlu M, Orakçı MA, Basan NM, et al. The role of ischemia-modified albumin, presepsin, delta neutrophil index, and inflammatory markers in diagnosing acute cholecystitis. Turk J Trauma Emerg Surg. 2024;30(4):242. 10.14744/tjtes.2024.67520.Suche in Google Scholar PubMed PubMed Central

[19] Chen L, Chen X. The role of different systemic inflammatory indexes derived from complete blood count in differentiating acute from chronic calculus cholecystitis and predicting its severity. J Inflamm Res. 2024;17:2051–62. 10.2147/JIR.S453146.Suche in Google Scholar PubMed PubMed Central

[20] Berhuni MS, Yönder H, Elkan H, Koyuncu MH, Özgül F, Tatlı F, et al. Diagnostic value of systemic immune inflammation index in identifying complicated acute appendicitis cases. Cureus. 2024;16(11):e73046. 10.7759/cureus.73046.Suche in Google Scholar PubMed PubMed Central

[21] Tiwari B, Sharma A, Vashishtha V. Systemic inflammation response index and systemic immune inflammation index as predictors of severity and acute kidney injury in acute pancreatitis. J Invest Surg. 2023;36(1):2152914. 10.1080/08941939.2022.2152914.Suche in Google Scholar PubMed

[22] Aktimur R, Cetinkunar S, Yildirim K, Aktimur SH, Ugurlucan M, Ozlem N. Neutrophil-to-lymphocyte ratio as a diagnostic biomarker for the diagnosis of acute mesenteric ischemia. Eur J Trauma Emerg Surg. 2016;42(3):363–8. 10.1007/s00068-015-0546-4.Suche in Google Scholar PubMed

[23] World Medical Association. Declaration of Helsinki on ethical principles for medical research involving human subjects. http://www.wma.net [accessed 2024 Nov 29].Suche in Google Scholar

[24] Karthikarajam V, Pushpaketu N, Badhai S, Mishra A, Sahu S, Debata I, et al. Risk factors associated with gangrenous cholecystitis: A cohort study from eastern India. Cureus. 2024;16(11):e74126. 10.7759/cureus.12345.Suche in Google Scholar PubMed PubMed Central

[25] Yalcin M, Tercan M, Özyurt E, Baysan A. The role of biomarkers in predicting perforated cholecystitis cases: Can the C-reactive protein albumin ratio be a guide? Turk J Trauma Emerg Surg. 2024;30(9):657–63. 10.14744/tjtes.2024.12345.Suche in Google Scholar

[26] Vural S, Aydın İE, Kesicioğlu T. Association of serum C-reactive protein level and treatment duration in acute cholecystitis patients treated conservatively. Cureus. 2022;14(8):e22146. 10.7759/cureus.22146.Suche in Google Scholar PubMed PubMed Central

[27] Gojayev A, Karakaya E, Erkent M, Yücebaş SC, Aydin HO, Kavasoğlu L, et al. A novel approach to distinguish complicated and non-complicated acute cholecystitis: Decision tree method. Medicine (Baltim). 2023;102(19):e33749. 10.1097/MD.0000000000033749.Suche in Google Scholar PubMed PubMed Central

[28] Li D, Yue Z, Weng Y, Zhen G. Diagnostic value of ROC curve evaluation of serum markers in acute cholecystitis with bacterial infection. J Pak Med Assoc. 2022;72(8):1634–40. 10.47391/jpma.3422.Suche in Google Scholar PubMed

[29] Yazar FM, Yazar A, Yazar B. Predictive value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in small bowel obstruction. Ulus Travma Acil Cerrahi Derg. 2021;27(4):446–52. 10.14744/tjtes.2020.30891.Suche in Google Scholar

[30] Özdemir H, Yazar C, Yazar D. Use of NLR and CRP in the prediction of complicated acute diverticulitis. Ann Coloproctol. 2022;38(2):105–11. 10.3393/ac.2021.00691.Suche in Google Scholar

[31] Şahin A, Yazar E, Yazar F. Diagnostic value of systemic inflammatory indices in incarcerated inguinal hernia: A prospective cohort study. Hernia. 2023;27(3):689–96. 10.1007/s10029-022-02667-1.Suche in Google Scholar
Received: 2024-12-06
Revised: 2025-05-27
Accepted: 2025-05-28
Published Online: 2025-07-24

© 2025 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Artikel in diesem Heft

  1. Research Articles
  2. Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
  3. Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
  4. Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
  5. Risk factors for severe adverse drug reactions in hospitalized patients
  6. Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
  7. Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
  8. CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
  9. Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
  10. Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
  11. Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
  12. Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
  13. Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
  14. Association between statin administration and outcome in patients with sepsis: A retrospective study
  15. Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
  16. A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
  17. Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
  18. Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
  19. Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
  20. Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
  21. Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
  22. The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
  23. Health literacy and health-related quality of life: The mediating role of irrational happiness
  24. Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
  25. Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
  26. Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
  27. Clinical analysis of ten cases of HIV infection combined with acute leukemia
  28. Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
  29. Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
  30. Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
  31. Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
  32. Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
  33. The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
  34. The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
  35. Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
  36. Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
  37. Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
  38. The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
  39. Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
  40. A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
  41. A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  42. Identifying early screening factors for depression in middle-aged and older adults: A cohort study
  43. Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
  44. Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
  45. High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
  46. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Review Articles
  128. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  129. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  130. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  131. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  132. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  133. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  134. The application of augmented reality in robotic general surgery: A mini-review
  135. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  136. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  137. Plant polyphenols, terpenes, and terpenoids in oral health
  138. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  139. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  140. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  141. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  142. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  143. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  144. Giant borderline ovarian tumours – review of the literature
  145. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  146. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  147. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  148. Supplement strategies for infertility in overweight women: Evidence and legal insights
  149. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  150. Case Reports
  151. Delayed graft function after renal transplantation
  152. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  153. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  154. Giant right atrial hemangioma presenting with ascites: A case report
  155. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  156. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  157. Rapid Communication
  158. Biological properties of valve materials using RGD and EC
  159. Letter to the Editor
  160. Role of enhanced external counterpulsation in long COVID
  161. Expression of Concern
  162. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  163. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  164. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  165. Corrigendum
  166. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  167. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  168. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  169. Retraction
  170. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  171. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  172. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  173. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  174. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  175. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  176. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  177. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  178. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  179. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  180. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  181. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  182. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  183. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  184. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  185. Special Issue Diabetes
  186. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  187. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  188. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  189. A review of brain research on T2DM-related cognitive dysfunction
  190. Special Issue Biomarker Discovery and Precision Medicine
  191. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
https://doi.org/10.1515/med-2025-1227
Schlagwörter für diesen Artikel
acute cholecystitis; diagnosis; neutrophils; systemic immune-inflammation index; systemic inflammatory response index
Creative Commons
BY 4.0

Artikel in diesem Heft

  1. Research Articles
  2. Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
  3. Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
  4. Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
  5. Risk factors for severe adverse drug reactions in hospitalized patients
  6. Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
  7. Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
  8. CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
  9. Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
  10. Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
  11. Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
  12. Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
  13. Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
  14. Association between statin administration and outcome in patients with sepsis: A retrospective study
  15. Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
  16. A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
  17. Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
  18. Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
  19. Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
  20. Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
  21. Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
  22. The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
  23. Health literacy and health-related quality of life: The mediating role of irrational happiness
  24. Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
  25. Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
  26. Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
  27. Clinical analysis of ten cases of HIV infection combined with acute leukemia
  28. Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
  29. Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
  30. Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
  31. Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
  32. Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
  33. The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
  34. The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
  35. Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
  36. Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
  37. Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
  38. The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
  39. Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
  40. A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
  41. A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  42. Identifying early screening factors for depression in middle-aged and older adults: A cohort study
  43. Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
  44. Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
  45. High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
  46. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Review Articles
  128. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  129. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  130. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  131. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  132. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  133. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  134. The application of augmented reality in robotic general surgery: A mini-review
  135. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  136. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  137. Plant polyphenols, terpenes, and terpenoids in oral health
  138. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  139. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  140. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  141. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  142. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  143. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  144. Giant borderline ovarian tumours – review of the literature
  145. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  146. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  147. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  148. Supplement strategies for infertility in overweight women: Evidence and legal insights
  149. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  150. Case Reports
  151. Delayed graft function after renal transplantation
  152. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  153. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  154. Giant right atrial hemangioma presenting with ascites: A case report
  155. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  156. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  157. Rapid Communication
  158. Biological properties of valve materials using RGD and EC
  159. Letter to the Editor
  160. Role of enhanced external counterpulsation in long COVID
  161. Expression of Concern
  162. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  163. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  164. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  165. Corrigendum
  166. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  167. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  168. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  169. Retraction
  170. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  171. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  172. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  173. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  174. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  175. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  176. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  177. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  178. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  179. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  180. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  181. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  182. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  183. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  184. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  185. Special Issue Diabetes
  186. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  187. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  188. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  189. A review of brain research on T2DM-related cognitive dysfunction
  190. Special Issue Biomarker Discovery and Precision Medicine
  191. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
Jetzt anmelden und 20% sparen
Institutioneller Zugang
Wie funktioniert Authentifizierung?
Haben Sie eine Idee, wie wir unsere Website verbessern können?
Bitte schreiben Sie uns.
© 2025 De Gruyter Brill
Heruntergeladen am 30.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/med-2025-1227/html
Button zum nach oben scrollen