Startseite Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
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Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients

  • Müslüm Ergün EMAIL logo und Süleyman Sağır
Veröffentlicht/Copyright: 11. September 2025

Abstract

Background and aim

The aim of this study is to investigate whether certain clinical nomograms influencing the success of extracorporeal shock wave lithotripsy (ESWL) also play a role in determining the number of treatment sessions required in patients who achieved stone-free status following ESWL.

Methods

The data of 354 patients with successful ESWL outcomes were analyzed. Patients were evaluated 4–6 weeks post-ESWL using X-ray, ultrasound, or computed tomography. The presence of residual stones larger than 4 mm was considered a treatment failure. Data recorded included age, gender, laterality of stone localization (right/left), stone location (renal pelvis, mid calyx, upper calyx, proximal ureter, mid ureter, distal ureter), stone size (maximum longitudinal dimension), body mass index (BMI), and stone Hounsfield unit (HU) values. Patients were categorized into two groups: single-session and multiple-session treatment.

Results

In the univariate model, factors such as age, BMI, distal ureter, renal pelvis, mid-calyx stone localization, stone size, and stone HU value showed a significant (p < 0.05) effect in distinguishing between single-session and multiple-session groups. Stone size and HU values were significantly higher (p < 0.05) in the multiple-session group compared to the single-session group. In the multivariate model, age, stone size, and HU value emerged as significant independent factors (p < 0.05) in differentiating between single-session and multiple-session treatments.

Conclusion

Several factors influencing the success of ESWL also affect the number of sessions required. BMI, age, stone size, stone HU value, and certain stone locations are key determinants of the number of ESWL sessions.

1 Introduction

Despite advancements in laser technologies and endoscopic tools, extracorporeal shock wave lithotripsy (ESWL) remains a significant non-invasive method for the treatment of urinary stone disease. Currently, it is considered the first-line treatment for kidney and proximal ureter stones smaller than 2 cm [1,2]. Modern urologists utilize a wide range of techniques in the management of urolithiasis, including ESWL, ureteroscopy, percutaneous nephrolithotomy (PCNL), retrograde intrarenal surgery (RIRS), as well as open or laparoscopic procedures.

While ESWL holds a prominent place in the treatment of urinary stones, its success rates are generally lower compared to more invasive techniques such as PCNL, RIRS, flexible, and rigid ureterorenoscopy [3,4]. Reported success rates for ESWL in the literature range from 82 to 91% [5,6]. Variations in these rates may stem from differences in inclusion and exclusion criteria or clinical limitations. Numerous factors influencing ESWL success have been identified in the literature, leading to the development of various clinical nomograms.

These nomograms consider parameters such as urinary system anatomy, stone size, location, composition, body mass index (BMI), skin-to-stone distance (SSD), ESWL equipment used, hydronephrosis, and stone Hounsfield unit (HU) values [7,8,9]. By incorporating these factors, clinical nomograms aim to predict stone-free rates (SFR) and assess the likelihood of ESWL success.

The aim of this study is to investigate whether certain clinical nomograms influencing ESWL success also have an impact on the number of treatment sessions required in patients who achieved stone-free status following ESWL.

2 Materials and methods

Between January 2022 and March 2024, adult patients presenting to our outpatient clinic with kidney stones were included in the study after retrospective data collection. Patients with stones measuring 5–20 mm who consented to treatment underwent ESWL. Patients excluded from the study included those with unsuccessful ESWL outcomes (residual stones larger than 4 mm), those with double-J stents, stones larger than 20 mm, lower pole kidney stones, or BMI ≥ 35. Data from 354 patients with successful ESWL outcomes were analyzed.

Patients were evaluated 4–6 weeks after ESWL using X-ray, ultrasound (US), or computed tomography (CT). Residual stones larger than 4 mm were defined as treatment failure. In addition, all patients included in the study were given alpha blockers for 1 month. Parameters recorded included age, gender, stone laterality (right/left), stone localization (renal pelvis, mid calyx, upper calyx, proximal ureter, mid ureter, distal ureter), stone size (maximum longitudinal dimension), BMI, and stone HU values. Patients were categorized into two groups: single-session and multiple-session treatments.

All patients underwent pre-procedural non-contrast helical CT. Laboratory investigations included urinalysis and urine culture. Patients with positive urine cultures received antibiotic therapy based on culture antibiogram results before the procedure. Patients were informed about treatment methods. Each session involved administering 2,000–2,500 shock waves at 80 shocks per minute with a power range of 13–17 kV. Fluoroscopy was used throughout the procedure to ensure optimal stone localization and to monitor treatment response. An Elmed device (Elmed Medical Systems Multimedia Classic/Turkey) was used for ESWL.

2.1 Data analysis

Descriptive statistics, including mean, standard deviation, median, minimum, maximum, frequency, and percentage, were used to summarize the data. The distribution of variables was assessed using the Kolmogorov–Smirnov and Shapiro–Wilk tests. For non-normally distributed independent quantitative variables, the Mann-Whitney U test was applied. For independent qualitative variables, the Chi-square test was used, and Fisher’s test was applied when Chi-square assumptions were not met. The effect size and cutoff values were analyzed using the ROC curve. Univariate and multivariate logistic regression analyses were performed to assess effect sizes. Statistical analyses were conducted using SPSS version 28.0 (SPSS Inc, Chicago, IL, USA).

  1. Ethics approval and consent to participate: The study was conducted with the ethical approval from the University Faculty of Medicine Ethics Committee (E-22686390-050.99-42448) received date: 22/03/2023. All methods were performed in accordance with the relevant guidelines and regulations, and informed consent was obtained from all subjects and/or their legal guardians.

3 Results

The study included a total of 354 patients, comprising 96 females and 258 males. The mean age of the patients was 43.8 ± 11.9 years, and the mean BMI was 25.0 ± 4.5. Stones were located on the right side in 46.0% (163) of cases and on the left side in 54.0% (191). The mean stone size was 10.0 ± 4.4 mm, and the mean stone HU value was 770.0 ± 153.9 (Table 1).

Table 1

Demographic findings of the study

Min–Max Median Mean value ± SD/n (%)
Age 15.0–83.0 42.0 43.8 ± 11.9
Sex Female 96 27.1%
Male 258 72.9%
BMI 16.8–39.2 24.3 25.0 ± 4.5
Right 163 46.0%
Left 191 54.0%
Localization Proximal ureter 109 30.8%
Distal ureter 93 26.3%
Renal pelvis 73 20.6%
Mid ureter 41 11.6%
Mid calyx 26 7.3%
Upper calyx 12 3.4%
Stone size (mm) 5.0–20.0 9.0 10.0 ± 4.4
Stone HU 330.0–1260.0 790.0 770.0 ± 153.9
Number of sessions I 176 49.7%
II 88 24.9%
III 90 25.4%

The proportion of patients who underwent a single ESWL session was 49.7% (176), while 50.3% (178) required multiple sessions (Tables 1 and 2).

Table 2

Comparison of patients undergoing single-session and multiple-session ESWL

Single session (n:176) Multiple sessions (n:178)
Mean value ± SD/n (%) Median Mean value ± SD/n (%) Median p
Age 41.4 ± 11.4 40.0 46.1 ± 11.9 45.5 0.000 m
Sex Female 47 26.7% 49 27.5% 0.862 X²
Male 129 73.3% 129 72.5%
BMI 24.3 ± 4.3 24.1 25.7 ± 4.5 25.2 0.001 m
Right 79 44.9% 84 47.2% 0.664 X²
Left 97 55.1% 94 52.8%
Localization
Proximal ureter 58 33.0% 51 28.7% 0.381 X²
Distal ureter 61 34.7% 32 18.0% 0.000 X²
Renal pelvis 21 11.9% 52 29.2% 0.000 X²
Mid ureter 26 14.8% 15 8.4% 0.062 X²
Mid calyx 7 4.0% 19 10.7% 0.016 X²
Upper calyx 3 1.7% 9 5.1% 0.081 X²
Stone size (mm) 8.2 ± 3.1 7.0 11.9 ± 4.7 11.0 0.000 m
Stone HU 690.0 ± 136.9 700.0 849.0 ± 126.8 851.5 0.000 m

mMann-Whitney u test/ X²Ki-kare test (Fischer test).

In the group requiring multiple ESWL sessions, the mean age of the patients was significantly higher (p < 0.05) compared to the single-session group. Gender distribution did not show a statistically significant difference (p > 0.05) between the two groups. BMI was significantly higher (p < 0.05) in the multiple-session group compared to the single-session group. Laterality of stone localization (right/left) did not differ significantly (p > 0.05) between the two groups (Table 2).

Stone localization in the proximal ureter, mid ureter, and upper calyx did not show significant differences (p > 0.05) between the single-session and multiple-session groups. However, distal ureter stone localization was significantly lower (p < 0.05) in the multiple-session group compared to the single-session group. Conversely, stone localization in the renal pelvis and mid calyx was significantly higher (p < 0.05) in the multiple-session group compared to the single-session group (Table 2).

Stone size and HU values were significantly higher (p < 0.05) in the multiple-session group compared to the single-session group (Table 2).

In the univariate model, factors such as age, BMI, distal ureter, renal pelvis, mid-calyx stone localization, stone size, and stone HU values were observed to have a significant effect (p < 0.05) in distinguishing between single-session and multiple-session groups (Table 3).

Table 3

Univariate and multivariate model analysis

Univariate model Multivariate model
OR 95% GA p OR 95% GA p
Age 1.036 1.017–1.055 0.000 1.026 1.003–1.049 0.028
BMI 1.078 1.026–1.132 0.003
Localization
Distal ureter 2.420 1.479–3.961 0.000
Renal pelvis 0.328 0.188–0.574 0.000
Mid calyx 0.347 0.142–0.847 0.020
Stone size (mm) 1.285 1.200–1.376 0.000 1.226 1.142–1.316 0.000
Stone HU 1.010 1.007–1.012 0.000 1.009 1.007–1.012 0.000

Logistic Regression (Forward LR).

In the multivariate model, age, stone size, and HU values emerged as significant independent factors (p < 0.05) in differentiating between single-session and multiple-session treatments (Table 3).

Stone size demonstrated a significant effect in distinguishing between single-session and multiple-session patients, with an area under the curve (AUC) of 0.753 (95% CI: 0.702–0.805) (Table 4). A cutoff value of 10 mm for stone size was observed to have a significant effect, with an AUC of 0.729 (95% CI: 0.676–0.783) (Figure 1). At the 10 mm cutoff value, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for distinguishing between single-session and multiple-session patients were 66.3, 79.5, 76.6, and 70.0%, respectively (Table 4).

Table 4

Effectiveness of stone size between single-session and multi-session patients

AUC 95% CI p
Stone size (mm) 0.753 0.702–0.805 0.000
Stone size 10 cut off 0.729 0.676–0.783 0.000
Single session Multiple sessions %
Stone size <10 140 60 Sensitivity 66.3%
≥10 36 118 PPV 76.6%
Specificity 79.5%
NPV 70.0%

ROC Curve.

Figure 1 
               Efficacy graph of stone size between single-session and multi-session patients.
Figure 1

Efficacy graph of stone size between single-session and multi-session patients.

The HU value of the stone demonstrated a significant effect in distinguishing between single-session and multiple-session patients, with an AUC of 0.801 (95% CI: 0.756–0.846) (Table 5).

Table 5

Effectiveness of stone HU value between single-session and multi-session patients

AUC 95% CI P
Stone HU 0.801 0.756–0.846 0.000
Stone HU 755 cutoff 0.737 0.684–0.790 0.000
Single session Multiple sessions %
Stone HU <755 113 30 Sensitivity 83.1%
≥755 63 148 PPV 70.1%
Specificity 64.2%
NPV 79.0%

ROC Curve.

A cutoff value of 755 HU for the stone was also found to have a significant effect, with an AUC of 0.737 (95% CI: 0.684–0.790) (Figure 2).

Figure 2 
               Effectiveness graph of stone HU value in single-session and multi-session patients.
Figure 2

Effectiveness graph of stone HU value in single-session and multi-session patients.

At the 755 HU cutoff value, the sensitivity, specificity, PPV, and NPV for distinguishing between single-session and multiple-session patients were 83.1, 64.2, 70.1, and 79.0%, respectively (Table 5).

4 Discussion

Since the 1980s, ESWL has remained a popular and preferred method for the safe, non-invasive treatment of uncomplicated kidney and ureteral stones (≤20 mm in diameter) [10]. Previous studies have identified predictive factors such as patient age, stone size, stone location, SSD, stone density, severity of obstruction, BMI, urinary system anatomy, and the type of ESWL device, all of which can influence the success of ESWL [11,12]. This study sought to determine whether these predictive factors, in patients who achieved successful outcomes, also impacted the number of sessions required, by categorizing patients into single-session and multiple-session groups.

No significant difference was observed in gender or stone laterality between the groups, suggesting that these factors are not influential in determining the number of ESWL sessions. Similarly, prior research has shown that neither factor significantly affects SFR [13]. Regarding stone location, significant differences were observed between the groups for renal pelvis, mid calyx, and distal ureter stones, while no significant differences were found for stones located in the proximal ureter, mid ureter, or upper calyx. Multiple sessions were more effective for renal pelvis and mid calyx stones, whereas single sessions were more effective for distal ureter stones. Although the literature often associates lower ESWL success rates with distal ureter stones, potentially necessitating more sessions, discrepancies in our results may stem from factors such as stone size, stone HU value, and BMI.

Age and BMI have previously been identified as significant predictors of ESWL success [13,14,15]. In this study, both factors significantly influenced session count in the univariate model, with older age and higher BMI correlating with an increased number of sessions. The mean age of our cohort was 43.8 ± 11.9 years, aligning with the global prevalence of urolithiasis in individuals aged 40–50 years [16]. Although the influence of age diminishes over extended follow-up periods, it remains a strong determinant of SFR after ESWL [17]. Age-related sclerotic changes in renal parenchyma may increase acoustic impedance, leading to lower SFR and higher session counts [14]. Unlike BMI, age remained a significant independent factor in the multivariate model, highlighting its strong impact on session count.

While SSD measurements were not included in this retrospective study, SSD is known to correlate linearly with BMI [18]. Obese patients experience reduced energy transmission to the stone, resulting in decreased SFR [19,20]. In our study, higher BMI was a significant factor in the univariate model but did not demonstrate similar effects in the multivariate model. This aligns with findings from other studies where SSD was a predictor of ESWL failure in univariate analysis but not in multivariate analysis [18].

Both stone size and HU value were significant factors in distinguishing between single-session and multiple-session patients in both univariate and multivariate models. Stone size is a critical variable in determining the appropriateness of ESWL. A prospective study involving 130 patients reported that larger stone sizes required more ESWL sessions [21]. Similarly, other studies have identified a 10 mm cutoff for stone size as an independent predictor of ESWL success [22]. Our study also found a 10 mm cutoff for distinguishing between single-session and multiple-session groups, with an AUC of 0.729 (95% CI: 0.676–0.783). Stones larger than 10 mm necessitate more sessions for successful fragmentation, as corroborated by prior research indicating an average of 1.4 sessions for stones ≤10 mm and 2.1 sessions for stones >10 mm [18].

Stone HU value is another critical factor influencing stone clearance rates. Higher HU values are associated with lower ESWL success and are frequently used to predict treatment outcomes [5,8]. Studies have consistently shown a positive relationship between lower HU values and higher SFR [8,19,23,24]. Evidence from a prospective study demonstrated higher ESWL success rates for stones with HU <970, with a linear relationship observed between stone density and SFR for stones below this threshold [16]. In our study, a 755 HU cutoff was identified as significant in distinguishing between single-session and multiple-session groups, with an AUC of 0.737 (95% CI: 0.684–0.790). This finding underscores the potential of HU values in predicting ESWL success, enabling optimized session planning and cost reduction by minimizing unnecessary sessions.

5 Conclusion

Several factors influencing ESWL success also affect the number of sessions required. BMI, age, stone size, stone HU values, and certain stone locations emerged as significant determinants of session count. Among these, stone size and HU value were identified as the most critical independent factors. By considering these variables, the number of ESWL sessions required can be predicted, contributing to the optimization of treatment management.

6 Study limitations

This study has several limitations due to its retrospective design. Only sessions of patients who underwent successful ESWL treatment were analyzed, while sessions of those with unsuccessful outcomes were not included, limiting the ability to make comparisons. Additionally, clinical follow-up data did not include measurements for SSD or US shear wave elastography (SWE). Furthermore, data for lower pole kidney stones were insufficient, and therefore, these cases were excluded from the study. As a result, no conclusions regarding session requirements for SSD, SWE, or lower pole kidney stones can be drawn.

  1. Funding information: The authors state no funding involved.

  2. Author contributions: Concept – M.E.; design and supervision – S.S.; resources – M.E.; materials – M.E. and S.S.; data collection and/or processing – M.E.; analysis and/or interpretation – S.S.; literature search – M.E. and S.S.; writing manuscript – M.E. and S.S.; critical review – S.S.; and others – M.E.

  3. Conflict of interest: The authors state no conflict of interest.

  4. Data availability statement: The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.

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Received: 2024-12-12
Revised: 2025-05-31
Accepted: 2025-08-05
Published Online: 2025-09-11

© 2025 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Review Articles
  128. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  129. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  130. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  131. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  132. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  133. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  134. The application of augmented reality in robotic general surgery: A mini-review
  135. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  136. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  137. Plant polyphenols, terpenes, and terpenoids in oral health
  138. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  139. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  140. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  141. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  142. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  143. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  144. Giant borderline ovarian tumours – review of the literature
  145. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  146. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  147. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  148. Supplement strategies for infertility in overweight women: Evidence and legal insights
  149. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  150. Case Reports
  151. Delayed graft function after renal transplantation
  152. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  153. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  154. Giant right atrial hemangioma presenting with ascites: A case report
  155. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  156. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  157. Rapid Communication
  158. Biological properties of valve materials using RGD and EC
  159. Letter to the Editor
  160. Role of enhanced external counterpulsation in long COVID
  161. Expression of Concern
  162. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  163. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  164. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  165. Corrigendum
  166. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  167. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  168. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  169. Retraction
  170. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  171. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  172. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  173. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  174. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  175. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  176. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  177. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  178. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  179. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  180. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  181. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  182. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  183. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  184. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  185. Special Issue Diabetes
  186. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  187. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  188. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  189. A review of brain research on T2DM-related cognitive dysfunction
  190. Special Issue Biomarker Discovery and Precision Medicine
  191. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
Heruntergeladen am 30.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/med-2025-1276/html
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