Startseite Medizin Effect of timing of cholecystectomy on weight loss after sleeve gastrectomy in morbidly obese individuals with cholelithiasis: a retrospective cohort study
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Effect of timing of cholecystectomy on weight loss after sleeve gastrectomy in morbidly obese individuals with cholelithiasis: a retrospective cohort study

  • Ramazan Saygin Kerimoglu ORCID logo , Suleyman Kargin ORCID logo , Aysegul Yilmaz Sirit ORCID logo , Melek Yalcin Koc ORCID logo und Abdullah Gurhan Duyan ORCID logo EMAIL logo
Veröffentlicht/Copyright: 17. Dezember 2025
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Aus der Zeitschrift Open Medicine Band 20 Heft 1

Abstract

Objectives

Obesity and gallbladder stone disease are strongly connected conditions. Nonetheless, the concomitant performance of cholecystectomy alongside sleeve gastrectomy remains contentious in individuals with asymptomatic gallstones. This study examines the impact of cholecystectomy timing on weight loss following sleeve gastrectomy.

Methods

A retrospective assessment was conducted on the records of 94 patients who underwent bariatric surgery from 2021 to 2025. The effect on weight loss (% EWL), insulin resistance, and other metabolic parameters was evaluated in patients who underwent concomitant cholecystectomy with sleeve gastrectomy, those who had cholecystectomy six months post-surgery, and those who received cholecystectomy prior to sleeve gastrectomy.

Results

Out of 94 patients, 29 (30.8 %) received concomitant cholecystectomy. It was established that patients who received late cholecystectomy experienced reduced complication rates, shorter hospital stays, and decreased operation times compared to other groups. Fasting glucose and insulin resistance levels were significantly reduced in the late group at the 3rd and 6th months, but they diminished at the 6th month in the contemporaneous group (p<0.05). The augmentation in EWL% was markedly superior in the late group relative to the other groups commencing from the third month (p<0.05).

Conclusions

Postponing the treatment of asymptomatic gallbladder disease after sleeve gastrectomy is both safe and may yield beneficial effects on weight reduction and insulin sensitivity.

Keywords: sleeve gastrectomy; cholecystectomy; timing; weight loss

Introduction

Strategies for addressing obesity have emerged as a prominent research focus globally. Bariatric surgery has been demonstrated to be the gold standard for the most immediate and enduring treatment of obesity, effectively reducing obesity-related comorbidities in the long term [1].

The prevalence of gallbladder stone disease (GSD) in obese individuals is quintuple that of healthy individuals [2]. Moreover, GSD manifests in roughly 30–40 % of patients who undergo bariatric surgery within the initial six months [3], 4]. This may be attributed to the presence of two risk factors in persons undergoing this surgery: obesity and quick weight loss. Consequently, GSD treatment is crucial for obese individuals.

A consensus on the management of GSD during bariatric surgery remains elusive. Certain authors advocate for conducting bariatric surgery without cholecystectomy in patients with asymptomatic GSD, as it decreases morbidity and length of hospital stay [5], 6]. Nevertheless, in this instance, prospective GSD problems and a subsequent operation may necessitate rehospitalization. In light of these issues, several articles have indicated that concomitant cholecystectomy (CC) is safer and more cost-effective [7], [8], [9]. Although CC during bariatric surgery has been discussed in numerous clinical studies and meta-analyses, these studies have evaluated the risks of complications, overall cost concerns, and additional treatment needs. This study approaches this general perspective from a different perspective, focusing on the impact of cholecystectomy timing on postbariatric outcomes by considering the gallbladder’s ameliorative effects on glucose metabolism.

Despite cholecystectomy being one of the most prevalent surgical interventions globally, there remains contention on its metabolic consequences. The prevalence of heightened insulin resistance in people post-cholecystectomy indicates that the gallbladder exerts physiological influences on insulin sensitivity [10]. The increasing data concerning the gallbladder’s role in insulin homeostasis prompts inquiries about its influence on weight loss following bariatric surgery. Currently, there is no evidence in the literature to substantiate this claim.

This study sought to examine the impact of cholecystectomy timing on weight reduction and insulin resistance in patients who underwent bariatric surgery for GSD. The metabolic consequences of cholecystectomy timing were assessed in obese patients with asymptomatic GSD.

Materials and methods

This research is a retrospective observational study utilizing prospective data collected over four years at a single tertiary referral hospital. The research received approval from the hospital ethics committee (document number: 2025/63, date: 18 January 2025). The research was performed in compliance with the 1964 Helsinki Declaration and its subsequent revisions or comparable ethical norms. Data from patients who underwent laparoscopic sleeve gastrectomy (LSG) between January 2021 and 2025 were analyzed. Data from surgeons who had performed bariatric surgery at the same hospital for at least 5 or more years were included in the study. The timing of cholecystectomy was determined by the surgeon’s own preference. Therefore, the timing of cholecystectomy was not affected by demographic or clinical characteristics.

Patients who had cholecystectomy for GSD before bariatric surgery and were diagnosed with GSD during the preoperative assessment were included in the study. Patients were categorized into three groups: Previous: individuals who underwent cholecystectomy previous to bariatric surgery; Concomitant: individuals who underwent cholecystectomy simultaneously with bariatric surgery; Late: individuals who underwent cholecystectomy 6 months or more after bariatric surgery due to symptomatic gallstone disease.

All patients were adults (≥18 years of age). All participants received a preoperative multidisciplinary assessment and satisfied the National Institutes of Health (NIH) consensus criteria for metabolic and bariatric surgery (MBS), specifically a body mass index (BMI) of ≥40 kg/m2, or a BMI of ≥35 kg/m2 accompanied by one or more obesity-related medical conditions.

The primary endpoint of the study was weight loss and therefore the %EWL parameter, while the secondary endpoint was the effects of glucose on the HOMA-IR score, which is a parameter of insulin sensitivity.

The study comprised patients having preoperative hepatobiliary ultrasonography reports. The exclusion criteria encompassed any previous metabolic and bariatric surgery (e.g., LSG), advanced organ failure (liver, kidney, or heart), malignancies, acute inflammatory or infectious diseases, administration of ursodeoxycholic acid during the post-bariatric period, and patients with incomplete medical records or those who could not be contacted. The patients were categorized into three groups based on the timing of cholecystectomy. Prior to bariatric surgery, concurrent cholecystectomy, and more than six months post-bariatric surgery. The demographic information of patients with comorbidities (diabetes, hypertension, dyslipidemia, hypothyroidism, and sleep apnea); pre-operative biochemical parameters (fasting blood glucose, insulin, cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), alanine transaminase (ALT), aspartate transaminase (AST); HOMA-IR score, weight, and percentage of excess body weight loss (%EWL) prior to and at 1, 3, and 6 months post-surgery. Patients’ weight, EWL%, and HOMA-IR score were assessed. The total percentage of excess weight loss (EWL%) was computed as follows: (preoperative weight–desired body weight) * 100. The HOMA-IR score is calculated by multiplying the fasting glucose level by fasting insulin and dividing the result by 405. The optimal body weight was determined using a standard BMI of 25 kg/m2.

Data analysis

For numerical variables, the mean and standard deviation or median (Q1-Q3) values are presented, but for categorical variables, the frequency and percentage values are provided. Chi-square or Fisher’s exact tests were employed for the study of categorical data, and ANOVA or mixed effects models (where HOMA-IR included as a covariate) were utilized for the analysis of numerical variables. In multiple comparisons, least squares means were analyzed used Tukey adjusted. The parameters evaluated in the study were evaluated at a 95 % confidence interval. In the models, group, time, and the group × time interaction were defined as fixed effects, while individuals were defined as random effects. F tests were reported for main effects, and effect sizes were calculated using partial eta squared (η2p). Effect size was reported using Cohen’s d in significant comparisons. Analyses were conducted utilizing the R 4.5.1 software (R Core Team, 2024). A p-value of less than 0.05 was deemed statistically significant.

Results

Table 1 presents the analysis of demographic data of patients categorized by groups. The predominant demographic among the 94 patients in the study was female, comprising 91.4 % of the cohort. No mortality, reoperation, or conversion to open surgery occurred in any of the cohorts. Postoperative hemorrhage at the staple line was noted in 4 individuals (4.25 %). One patient (1.06 %) necessitated a blood transfusion. During the extended follow-up, a trocar hernia was identified in one patient (1.06 %). The duration of the operation and hospital stay was markedly reduced in the late group patients relative to the other groups (p<0.05).

Table 1:

Demographic data of patient groups.

Concominant (N 29) Previous (N 41) Late (N 24) p-Value
Mean ± SD Mean ± SD Mean ± SD
Age 37.41 ± 10.62 41.02 ± 12.16 33.75 ± 11.32 0.060
Sex
 Female 26 (90 %) 41 (100 %) 19 (79 %) 0.006
 Male 3 (10 %) 0 (0 %) 5 (21 %)
BMI, kg/m2 46.75 ± 6.88 47.02 ± 6.13 45.80 ± 5.71 0.192
Complication Bleeding (1)

Trocar hernia (1)		 Bleeding (3) None
Hospital stay/day 3.21 ± 0.46 2.78 ± 0.32 2.1 ± 0.20 0.042
Operation time/min 98 ± 14.5 75 ± 12.84 52 ± 12.45 0.012

  1. N: Patient number, SD:Standard Deviation BMI:Body Mass Index, Min:Minute,kg:kilogram, m:meter. 1One-way analysis of means (not assuming equal variances); Chi-square or Fisher’s exact test. p<0.05 indicates statistical significant.

Figure 1 displays the laboratory analyses of the patients. No significant differences were seen between the groups regarding total cholesterol, triglycerides, HDL, LDL, AST, and ALT levels. substantial reductions were noted in all levels except HDL when compared to preoperative values, while HDL exhibited a substantial rise after 6 months (p<0.01).

Figure 1: Laboratory parameters means of both groups with 95 % confidence interval during postoperative follow-up. HDL: High density lipoprotein, LDL: Low density lipoprotein, AST: Aspartate aminotransferase, ALT: Alanin aminotransferase.
Figure 1:

Laboratory parameters means of both groups with 95 % confidence interval during postoperative follow-up. HDL: High density lipoprotein, LDL: Low density lipoprotein, AST: Aspartate aminotransferase, ALT: Alanin aminotransferase.

Figure 2 summarizes the fasting glucose and HOMA-IR readings of the patients. The contemporaneous group exhibited a notable reduction in fasting glucose levels at 6 months relative to preoperative values (p=0.003), but the late group demonstrated significant decreases at both 3 and 6 months compared to preoperative values (p=0.004 and p=0.007, respectively). Nonetheless, in the preceding group, no significant difference was seen over time in comparison to preoperative values (p=0.931). Accordingly, in the Concomitant and Previous groups, changes between Preop and subsequent months had mostly small to small-medium effects, while in the Late group, comparisons between Preop–3rd month (d=0.44) and Preop–6th month (d=0.44) showed medium-sized effects (Figure 2).

Figure 2: Changes in fasting glucose and HOMA IR scores means of both groups with 95 % confidence interval during postoperative follow-up. The main effect of time was large (η²p=0.315), the main effect of group was insignificant (η²p=0.011), and the group time interaction was small to moderate (η²p=0.052) for HOMA-IR score.
Figure 2:

Changes in fasting glucose and HOMA IR scores means of both groups with 95 % confidence interval during postoperative follow-up. The main effect of time was large (η²p=0.315), the main effect of group was insignificant (η²p=0.011), and the group time interaction was small to moderate (η²p=0.052) for HOMA-IR score.

Figure 3 illustrates the impact of cholecystectomy timing on weight and excess weight loss (EWL). While no change in EWL levels was noted between groups at 1 month, a significant rise was seen in the late group compared to the prior group at 3 months (p=0.003). At six months, a notable rise was seen in the late group compared to both the prior and concurrent groups (p=0.000, p=0.032, respectively). The increase in EWL levels between the concurrent and prior groups was consistent across all months (p>0.05).

Figure 3: Comparison of weight loss and EWL levels means of both groups with 95 % confidence interval in postoperative follow-ups. For EWL, the main effect of time was very strong (η²p=0.877), the effect of group was small to moderate (η²p=0.087), and the group x time interaction was medium in size (η²p=0.110). EWL%: Excess weight loss.
Figure 3:

Comparison of weight loss and EWL levels means of both groups with 95 % confidence interval in postoperative follow-ups. For EWL, the main effect of time was very strong (η²p=0.877), the effect of group was small to moderate (η²p=0.087), and the group x time interaction was medium in size (η²p=0.110). EWL%: Excess weight loss.

Discussion

In the surgical management of morbid obesity, cholecystectomy is still commonly favored in individuals with asymptomatic gallbladder stones, despite the ambiguity surrounding its necessity. Some studies highlight its potential to avert future procedures due to GS, while others indicate prolonged operational time and elevated complication rates without conclusive postoperative benefits. Advocates of simultaneous cholecystectomy assert that it is preferable to obviate the necessity for reoperation, given the potential problems linked to GSD and the tolerable rise in operative duration and complication rates [11], 12].

At now, 67.4 % of surgeons continue to choose CC [13]. A recent systematic review by Soares and colleagues indicated that the CC procedure results in a substantial increase in postoperative bleeding; patients undergoing this procedure experienced a markedly higher incidence of reoperation and postoperative complications, including wound, anastomotic, and respiratory issues [14]. Conversely, Raziel et al. indicated that 4 out of 43 patients (9.3 %) and Sioka et al. noted that 3 out of 23 patients (13 %) had symptoms necessitating cholecystectomy following LSG [15], 16]. Furthermore, in the most extensive investigation on bile duct injury subsequent to cholecystectomy, the incidence of such injuries was determined to be 1.1 %. While this percentage may appear minimal, it is regarded as relevant due to its potential to result in mortality following biliary surgery. Proponents of this perspective contend that CC is superfluous; they assert that in the future, only a minimal proportion of symptomatic GSD would necessitate surgical intervention, hence facilitating safer procedures by mitigating complications associated with obesity.

All current debates concentrate on the potential hazards linked to CC complications. Nevertheless, no prior research has examined the impact of the gallbladder on weight loss following bariatric surgery. In our study, we assessed the impact of the gallbladder on weight loss during the therapy period in asymptomatic gallbladder disease. Prior research indicates that the gallbladder plays physiological functions in glucose, lipid, and energy homeostasis, and that cholecystectomy results in insulin resistance [10]. Insulin resistance is a critical factor influencing weight reduction following sleeve gastrectomy. We expected that insulin resistance (IR) resulting from cholecystectomy would adversely impact weight loss. This study aims to assess gallbladder function in morbidly obese patients scheduled for surgery and diagnosed with asymptomatic gallstone disease. The primary aim of our study was to assess the gallbladder’s role in postoperative weight loss and to offer an additional rationale against doing cholecystectomy based on this notion. The results indicated a notable weight reduction and EWL rates favoring patients who did not have cholecystectomy (Figure 3). In our study, we designated patients with a history of cholecystectomy previous to surgery as the control group. This enabled us to ascertain that the timing of cholecystectomy and the gallbladder’s influence on weight reduction were substantial, even with asymptomatic stones present.

Our findings showed a significant decrease in glucose levels in individuals undergoing advanced cholecystectomy; however, the lack of a significant change in insulin resistance contradicts the existing literature. This result may be due to two factors: a) The late cholecystectomy group coincidentally included patients with higher HOMA-IR scores. Although no significant difference in insulin resistance levels was found between the groups, a greater decrease in preoperative HOMA-IR scores was observed in the late group (Figure 2). This result suggests that: a) The preoperative HOMA-IR score in the late group was significantly higher than in the other groups. However, it decreased to the mean levels of the other groups in the postoperative period. This may have reduced the statistical significance of the HOMA-IR calculations. b) Insulin resistance is not only associated with obesity but is also influenced by many physiological mechanisms (non-alcoholic fatty liver disease, sex hormones, gut microbiota, fat cell-associated chronic inflammation, etc.). Since the patients in this study were not examined for these physiological factors, the inconsistency in HOMA-IR scores may be due to the influence of these factors.

When assessed from an alternative viewpoint, asymptomatic GSD rarely becomes symptomatic. Doulamis et al. report that the rate of gallstone formation following bariatric surgeries may reach 35 %, however only one-third of these instances necessitate surgical intervention [17]. Thus, asymptomatic gallstones also rarely become symptomatic. Indeed, a multitude of articles has been published regarding the beneficial effects of ursodeoxycholic acid in the treatment of freshly developed gallstones [18]. Consequently, surgeons adopting a CC attitude can mitigate anticipated gallstone problems by managing patients pharmacologically instead of proceeding with cholecystectomy.

To our knowledge, no prior study has documented the post-operative blood values in patients following cholecystectomy after LSG. In a comparable study analyzing the metabolic characteristics of patients who received CC vs. those who did not, Machado et al. concluded that patients who did not undergo CC exhibited superior changes in lipid profile, fasting glucose, HbA1c, and insulin levels [19]. Our study examined preoperative fasting blood sugar, total cholesterol, triglycerides, HDL, LDL, ALT, and AST, revealing no statistically significant changes between the groups in both univariate and multivariate analyses. The absence of notable enhancements in these parameters in our study may be attributed to the non-preservation of the duodenum in gastric bypass procedures, facilitating the rapid transit of bile acids to the ileum and their subsequent absorption.

Proponents of concurrent cholecystectomy assert that it entails comparable surgical durations and complications (8). In our study, the surgical durations and hospital stay of patients with a history of cholecystectomy prior to CC and LSG were significantly longer compared to those in the late group. Despite statistical significance, the overall number of complications in our study is weaker due to the low number of complications.

Our limitations apply to all retrospective observational studies, as extended follow-up and homogeneous cohorts are necessary for a more accurate assessment of the proposed outcomes. Furthermore, the study’s power analysis was limited by the low incidence of symptomatic cholecystectomy after bariatric surgery.

Conclusions

The study advises against CC because of the gallbladder’s beneficial impact on weight loss, with asymptomatic GSD, surgical durations, and complication risks in people undergoing LSG.

Corresponding author: Abdullah Gurhan Duyan, Konya City Hospital, Konya, 42020, Türkiye, E-mail:

  1. Funding Information: This research received no external funding.

  2. Informed Consent Statement: Since this study was designed as a retrospective file review, informant consent forms were not obtained from the patients.

  3. Authors Contribution: RSK and SK: Conceived and designed the study, data collection, paper write-up, and the compilation of the results. AYS and AGD: Data collection, paper write-up. RSK and MYK: Data collection, discussion, statistical analyses, SK and AYS: discussion, and proofreading, RSK: Data collection, discussion.

  4. Conflicts of Interest: The authors declare no conflicts of interest.

  5. Data Availability Statement: The data presented in this study are available on request from the corresponding author due to ethical reasons.

References

1. Gjermeni, E, Kirstein, AS, Kolbig, F, Kirchhof, M, Bundalian, L, Katzmann, JL, et al.. Obesity-An update on the basic pathophysiology and review of recent therapeutic advances. Biomolecules 2021;11:1426. https://doi.org/10.3390/biom11101426.Suche in Google Scholar PubMed PubMed Central

2. Festi, D, Dormi, A, Capodicasa, S, Staniscia, T, Attili, AF, Loria, P, et al.. Incidence of gallstone disease in Italy: results from a multicenter, population-based Italian study (the MICOL project). World J Gastroenterol 2008;14:5282–9. https://doi.org/10.3748/wjg.14.5282.Suche in Google Scholar PubMed PubMed Central

3. Brockmeyer, JR, Grover, BT, Kallies, KJ, Kothari, SN. Management of biliary symptoms after bariatric surgery. Am J Surg 2015;210:1010–16. https://doi.org/10.1016/j.amjsurg.2015.07.003.Suche in Google Scholar PubMed

4. Chang, J, Corcelles, R, Boules, M, Jamal, MH, Schauer, PR, Kroh, MD, et al.. Predictive factors of biliary complications after bariatric surgery. Surg Obes Relat Dis 2016;12:1706–10. https://doi.org/10.1016/j.soard.2015.11.004.Suche in Google Scholar PubMed

5. Marciniak, C, Lenne, X, Bruandet, A, Hamroun, A, Génin, M, Baud, G, et al.. Risk-benefit balance of simultaneous gastric bypass or sleeve gastrectomy and concomitant cholecystectomy: a comprehensive nationwide cohort of 289,627 patients. Ann Surg 2023;278:725–31. https://doi.org/10.1097/SLA.0000000000006039.Suche in Google Scholar PubMed

6. Leyva-Alvizo, A, Arredondo-Saldaña, G, Leal-Isla-Flores, V, Romanelli, J, Sudan, R, Gibbs, KE, et al.. ASMBS foregut committee. Systematic review of management of gallbladder disease in patients undergoing minimally invasive bariatric surgery. Surg Obes Relat Dis 2020;6:158–64. https://doi.org/10.1016/j.soard.2019.10.016.Suche in Google Scholar PubMed

7. Hsu, FC, Pan, HM, Chen, YJ, Hung, WT, Lin, CH, Liao, GS, et al.. A practical port-sharing approach for concomitant cholecystectomy with laparoscopic sleeve gastrectomy: single-center experience. Rev Esp Enferm Dig 2023;115:462–4. https://doi.org/10.17235/reed.2022.9318/2022.Suche in Google Scholar PubMed

8. Yildirim, K, Karabicak, I, Gursel, MF, Karabicak, C, Malazgirt, Z. The outcome of concomitant cholecystectomy with bariatric surgery: a retrospective cohort study. Ann Med Surg 2023;85:718–21. https://doi.org/10.1097/MS9.0000000000000339.Suche in Google Scholar PubMed PubMed Central

9. Tustumi, F, Pinheiro Filho, JEL, Stolzemburg, LCP, Serigiolle, LC, Costa, TN, Pajecki, D, et al.. Management of biliary stones in bariatric surgery. Ther Adv Gastrointest Endosc 2022;15. https://doi.org/10.1177/26317745221105087. 26317745221105087.Suche in Google Scholar PubMed PubMed Central

10. Cӑtoi, AF, Pârvu, AE, Mironiuc, A, Silaghi, H, Pop, ID, Andreicuț, AD, et al.. Ultra-early and early changes in bile acids and insulin after sleeve gastrectomy among obese patients. Medicina (Kaunas) 2019;55:757. https://doi.org/10.3390/medicina55120757.Suche in Google Scholar PubMed PubMed Central

11. Habeeb, TAAM, Kermansaravi, M, Giménez, ME, Manangi, MN, Elghadban, H, Abdelsalam, SA, et al.. Sleeve gastrectomy and cholecystectomy are safe in obese patients with asymptomatic cholelithiasis. A multicenter randomized trial. World J Surg 2022;46:1721–33. https://doi.org/10.1007/s00268-022-06557-2.Suche in Google Scholar PubMed PubMed Central

12. Benarroch-Gampel, J, Lairson, DR, Boyd, CA, Sheffield, KM, Ho, V, Riall, TS, et al.. Cost-effectivenes analysis of cholecystectomy during Roux-en-Y gastric bypass for morbid obesity. Surgery 2012;152:363–75. https://doi.org/10.1016/j.surg.2012.06.013.Suche in Google Scholar PubMed PubMed Central

13. Kermansaravi, M, Shikora, S, Dillemans, B, Kurian, M, LaMasters, T, Vilallonga, R, et al.. The management of biliary disease in patients with severe obesity undergoing metabolic and bariatric Surgery-An international expert survey. Obes Surg 2024;34:1086–96. https://doi.org/10.1007/s11695-024-07101-y.Suche in Google Scholar PubMed

14. Almiron da R Soares, G, Godoi, A, C A Reis, P, Ponte Farias, AG, R Brandao, G, Fontel Pompeu, B, et al.. Is it safe to perform concomitant cholecystectomy in patients with confirmed gallbladder disease undergoing metabolic and bariatric surgery? An updated meta-analysis. Obes Surg 2025;35:1911–24. https://doi.org/10.1007/s11695-025-07821-9.Suche in Google Scholar PubMed

15. Raziel, A, Sakran, N, Szold, A, Goitein, D. Concomitant cholecystectomy during laparoscopic sleeve gastrectomy. Surg Endosc 2015;29:2789–93. https://doi.org/10.1007/s00464-014-4010-z.Suche in Google Scholar PubMed

16. Sioka, E; Zacharoulis, D; Zachari, E; Papamargaritis, D; Pinaka, O; Katsogridaki, G; et al.. Complicated gallstones after laparoscopic sleeve gastrectomy. J obesity. 2014, 2014, 468203. 5, https://doi.org/10.1155/2014/468203 Suche in Google Scholar PubMed PubMed Central

17. Doulamis, IP, Michalopoulos, G, Boikou, V, Schizas, D, Spartalis, E, Menenakos, E, et al.. Concomitant cholecystectomy during bariatric surgery: the jury is still out. Am J Surg 2019;218:401–10. https://doi.org/10.1016/j.amjsurg.2019.02.006.Suche in Google Scholar PubMed

18. Son, SY, Song, JH, Shin, HJ, Hur, H, Han, SU. Prevention of gallstones after bariatric surgery using ursodeoxycholic acid: a narrative review of literature. J Metab Bariatr Surg 2022;11:30–8. https://doi.org/10.17476/jmbs.2022.11.2.30.Suche in Google Scholar PubMed PubMed Central

19. Machado, NM, Cardinelli, CS, Shen, T, Santo, MA, Torrinhas, RS, Waitzberg, DL, et al.. Cholecystectomy - a potential selection bias in studies assessing the metabolic effects of bariatric surgeries. Sci Rep 2020;10:10683. https://doi.org/10.1038/s41598-020-66688-1.Suche in Google Scholar PubMed PubMed Central

Received: 2025-07-21
Accepted: 2025-10-11
Published Online: 2025-12-17

© 2025 the author(s), published by De Gruyter, Berlin/Boston

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Investigation of the pathogenic variants induced Sjogren’s syndrome in Turkish population
  128. Nucleotide metabolic abnormalities in post-COVID-19 condition and type 2 diabetes mellitus patients and their association with endocrine dysfunction
  129. TGF-β–Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization
  130. Ultrasound-guided unilateral versus bilateral erector spinae plane block for postoperative analgesia of patients undergoing laparoscopic cholecystectomy
  131. Profiling gut microbiome dynamics in subacute thyroiditis: Implications for pathogenesis, diagnosis, and treatment
  132. Delta neutrophil index, CRP/albumin ratio, procalcitonin, immature granulocytes, and HALP score in acute appendicitis: Best performing biomarker?
  133. Anticancer activity mechanism of novelly synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative on colon cancer cells
  134. H2valdien3 arrests the cell cycle and induces apoptosis of gastric cancer
  135. Prognostic relevance of PRSS2 and its immune correlates in papillary thyroid carcinoma
  136. Association of SGLT2 inhibition with psychiatric disorders: A Mendelian randomization study
  137. Motivational interviewing for alcohol use reduction in Thai patients
  138. Luteolin alleviates oxygen-glucose deprivation/reoxygenation-induced neuron injury by regulating NLRP3/IL-1β signaling
  139. Polyphyllin II inhibits thyroid cancer cell growth by simultaneously inhibiting glycolysis and oxidative phosphorylation
  140. Relationship between the expression of copper death promoting factor SLC31A1 in papillary thyroid carcinoma and clinicopathological indicators and prognosis
  141. CSF2 polarized neutrophils and invaded renal cancer cells in vitro influence
  142. Proton pump inhibitors-induced thrombocytopenia: A systematic literature analysis of case reports
  143. The current status and influence factors of research ability among community nurses: A sequential qualitative–quantitative study
  144. OKAIN: A comprehensive oncology knowledge base for the interpretation of clinically actionable alterations
  145. The relationship between serum CA50, CA242, and SAA levels and clinical pathological characteristics and prognosis in patients with pancreatic cancer
  146. Identification and external validation of a prognostic signature based on hypoxia–glycolysis-related genes for kidney renal clear cell carcinoma
  147. Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility
  148. Relationship of resting echocardiography combined with serum micronutrients to the severity of low-gradient severe aortic stenosis
  149. Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial
  150. The diagnostic performance of machine learning-based FFRCT for coronary artery disease: A meta-analysis
  151. Comparing biofeedback device vs diaphragmatic breathing for bloating relief: A randomized controlled trial
  152. Serum uric acid to albumin ratio and C-reactive protein as predictive biomarkers for chronic total occlusion and coronary collateral circulation quality
  153. Multiple organ scoring systems for predicting in-hospital mortality of sepsis patients in the intensive care unit
  154. Single-cell RNA sequencing data analysis of the inner ear in gentamicin-treated mice via intraperitoneal injection
  155. Suppression of cathepsin B attenuates myocardial injury via limiting cardiomyocyte apoptosis
  156. Influence of sevoflurane combined with propofol anesthesia on the anesthesia effect and adverse reactions in children with acute appendicitis
  157. Identification of hub genes related to acute kidney injury caused by sevoflurane anesthesia and endoplasmic reticulum stress
  158. 10.1515/med-2025-1313
  159. 10.1515/med-2025-1316
  160. Health education pathway for individuals with temporary enterostomies using patient journey mapping
  161. 10.1515/med-2025-1321
  162. 10.1515/med-2025-1324
  163. 10.1515/med-2025-1325
  164. 10.1515/med-2025-1327
  165. 10.1515/med-2025-1331
  166. Effect of timing of cholecystectomy on weight loss after sleeve gastrectomy in morbidly obese individuals with cholelithiasis: a retrospective cohort study
  167. 10.1515/med-2025-1337
  168. 10.1515/med-2025-1347
  169. 10.1515/med-2025-1360
  170. Multiple sclerosis and type 1 diabetes: a Mendelian randomization study of European ancestry
  171. Rapid pathogen identification in peritoneal dialysis effluent by MALDI-TOF MS following blood culture enrichment
  172. Comparison of open and percutaneous A1 pulley release in pediatric trigger thumb: a retrospective cohort study
  173. Review Articles
  174. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  175. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  176. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  177. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  178. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  179. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  180. The application of augmented reality in robotic general surgery: A mini-review
  181. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  182. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  183. Plant polyphenols, terpenes, and terpenoids in oral health
  184. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  185. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  186. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  187. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  188. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  189. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  190. Giant borderline ovarian tumours – review of the literature
  191. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  192. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  193. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  194. Supplement strategies for infertility in overweight women: Evidence and legal insights
  195. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  196. A meta-analysis of the effects of DBS on cognitive function in patients with advanced PD
  197. Protective role of selenium in sepsis: Mechanisms and potential therapeutic strategies
  198. Strategies for hyperkalemia management in dialysis patients: A systematic review
  199. C-reactive protein-to-albumin ratio in peripheral artery disease
  200. 10.1515/med-2025-1251
  201. 10.1515/med-2025-1330
  202. 10.1515/med-2025-1332
  203. Antibiotic prescribing patterns in general dental practice- a scoping review
  204. Clinical and medico-legal reflections on non-invasive prenatal testing
  205. Case Reports
  206. Delayed graft function after renal transplantation
  207. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  208. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  209. Giant right atrial hemangioma presenting with ascites: A case report
  210. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  211. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  212. Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report
  213. Coronary artery anomalies: A case of the “malignant” left coronary artery and its surgical management
  214. Combined VAT and retroperitoneoscopy for pleural empyema due to nephro-pleuric fistula in xanthogranulomatous pyelonephritis
  215. 10.1515/med-2025-1362
  216. Rapid Communication
  217. Biological properties of valve materials using RGD and EC
  218. A single oral administration of flavanols enhances short-term memory in mice along with increased brain-derived neurotrophic factor
  219. Letter to the Editor
  220. Role of enhanced external counterpulsation in long COVID
  221. Expression of Concern
  222. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  223. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  224. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  225. Corrigendum
  226. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  227. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  228. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  229. Retraction
  230. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  231. Retraction of: “LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through downregulating SP-A by sponging to miR-424”
  232. Retraction of: “SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways”
  233. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  234. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  235. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  236. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  237. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  238. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  239. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  240. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  241. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  242. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  243. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  244. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  245. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  246. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  247. Red cell distribution width predicts early kidney injury: A NHANES cross-sectional study
  248. Special Issue Diabetes mellitus: pathophysiology, complications & treatment
  249. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  250. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  251. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  252. A review of brain research on T2DM-related cognitive dysfunction
  253. Metformin and estrogen modulation in LABC with T2DM: A 36-month randomized trial
  254. Special Issue Innovative Biomarker Discovery and Precision Medicine in Cancer Diagnostics
  255. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
https://doi.org/10.1515/med-2025-1334
Schlagwörter für diesen Artikel
sleeve gastrectomy; cholecystectomy; timing; weight loss
Creative Commons
BY 4.0

Artikel in diesem Heft

  1. Research Articles
  2. Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
  3. Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
  4. Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
  5. Risk factors for severe adverse drug reactions in hospitalized patients
  6. Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
  7. Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
  8. CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
  9. Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
  10. Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
  11. Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
  12. Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
  13. Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
  14. Association between statin administration and outcome in patients with sepsis: A retrospective study
  15. Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
  16. A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
  17. Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
  18. Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
  19. Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
  20. Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
  21. Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
  22. The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
  23. Health literacy and health-related quality of life: The mediating role of irrational happiness
  24. Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
  25. Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
  26. Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
  27. Clinical analysis of ten cases of HIV infection combined with acute leukemia
  28. Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
  29. Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
  30. Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
  31. Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
  32. Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
  33. The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
  34. The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
  35. Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
  36. Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
  37. Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
  38. The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
  39. Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
  40. A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
  41. A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  42. Identifying early screening factors for depression in middle-aged and older adults: A cohort study
  43. Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
  44. Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
  45. High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
  46. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Investigation of the pathogenic variants induced Sjogren’s syndrome in Turkish population
  128. Nucleotide metabolic abnormalities in post-COVID-19 condition and type 2 diabetes mellitus patients and their association with endocrine dysfunction
  129. TGF-β–Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization
  130. Ultrasound-guided unilateral versus bilateral erector spinae plane block for postoperative analgesia of patients undergoing laparoscopic cholecystectomy
  131. Profiling gut microbiome dynamics in subacute thyroiditis: Implications for pathogenesis, diagnosis, and treatment
  132. Delta neutrophil index, CRP/albumin ratio, procalcitonin, immature granulocytes, and HALP score in acute appendicitis: Best performing biomarker?
  133. Anticancer activity mechanism of novelly synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative on colon cancer cells
  134. H2valdien3 arrests the cell cycle and induces apoptosis of gastric cancer
  135. Prognostic relevance of PRSS2 and its immune correlates in papillary thyroid carcinoma
  136. Association of SGLT2 inhibition with psychiatric disorders: A Mendelian randomization study
  137. Motivational interviewing for alcohol use reduction in Thai patients
  138. Luteolin alleviates oxygen-glucose deprivation/reoxygenation-induced neuron injury by regulating NLRP3/IL-1β signaling
  139. Polyphyllin II inhibits thyroid cancer cell growth by simultaneously inhibiting glycolysis and oxidative phosphorylation
  140. Relationship between the expression of copper death promoting factor SLC31A1 in papillary thyroid carcinoma and clinicopathological indicators and prognosis
  141. CSF2 polarized neutrophils and invaded renal cancer cells in vitro influence
  142. Proton pump inhibitors-induced thrombocytopenia: A systematic literature analysis of case reports
  143. The current status and influence factors of research ability among community nurses: A sequential qualitative–quantitative study
  144. OKAIN: A comprehensive oncology knowledge base for the interpretation of clinically actionable alterations
  145. The relationship between serum CA50, CA242, and SAA levels and clinical pathological characteristics and prognosis in patients with pancreatic cancer
  146. Identification and external validation of a prognostic signature based on hypoxia–glycolysis-related genes for kidney renal clear cell carcinoma
  147. Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility
  148. Relationship of resting echocardiography combined with serum micronutrients to the severity of low-gradient severe aortic stenosis
  149. Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial
  150. The diagnostic performance of machine learning-based FFRCT for coronary artery disease: A meta-analysis
  151. Comparing biofeedback device vs diaphragmatic breathing for bloating relief: A randomized controlled trial
  152. Serum uric acid to albumin ratio and C-reactive protein as predictive biomarkers for chronic total occlusion and coronary collateral circulation quality
  153. Multiple organ scoring systems for predicting in-hospital mortality of sepsis patients in the intensive care unit
  154. Single-cell RNA sequencing data analysis of the inner ear in gentamicin-treated mice via intraperitoneal injection
  155. Suppression of cathepsin B attenuates myocardial injury via limiting cardiomyocyte apoptosis
  156. Influence of sevoflurane combined with propofol anesthesia on the anesthesia effect and adverse reactions in children with acute appendicitis
  157. Identification of hub genes related to acute kidney injury caused by sevoflurane anesthesia and endoplasmic reticulum stress
  158. 10.1515/med-2025-1313
  159. 10.1515/med-2025-1316
  160. Health education pathway for individuals with temporary enterostomies using patient journey mapping
  161. 10.1515/med-2025-1321
  162. 10.1515/med-2025-1324
  163. 10.1515/med-2025-1325
  164. 10.1515/med-2025-1327
  165. 10.1515/med-2025-1331
  166. Effect of timing of cholecystectomy on weight loss after sleeve gastrectomy in morbidly obese individuals with cholelithiasis: a retrospective cohort study
  167. 10.1515/med-2025-1337
  168. 10.1515/med-2025-1347
  169. 10.1515/med-2025-1360
  170. Multiple sclerosis and type 1 diabetes: a Mendelian randomization study of European ancestry
  171. Rapid pathogen identification in peritoneal dialysis effluent by MALDI-TOF MS following blood culture enrichment
  172. Comparison of open and percutaneous A1 pulley release in pediatric trigger thumb: a retrospective cohort study
  173. Review Articles
  174. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  175. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  176. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  177. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  178. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  179. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  180. The application of augmented reality in robotic general surgery: A mini-review
  181. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  182. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  183. Plant polyphenols, terpenes, and terpenoids in oral health
  184. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  185. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  186. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  187. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  188. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  189. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  190. Giant borderline ovarian tumours – review of the literature
  191. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  192. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  193. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  194. Supplement strategies for infertility in overweight women: Evidence and legal insights
  195. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  196. A meta-analysis of the effects of DBS on cognitive function in patients with advanced PD
  197. Protective role of selenium in sepsis: Mechanisms and potential therapeutic strategies
  198. Strategies for hyperkalemia management in dialysis patients: A systematic review
  199. C-reactive protein-to-albumin ratio in peripheral artery disease
  200. 10.1515/med-2025-1251
  201. 10.1515/med-2025-1330
  202. 10.1515/med-2025-1332
  203. Antibiotic prescribing patterns in general dental practice- a scoping review
  204. Clinical and medico-legal reflections on non-invasive prenatal testing
  205. Case Reports
  206. Delayed graft function after renal transplantation
  207. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  208. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  209. Giant right atrial hemangioma presenting with ascites: A case report
  210. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  211. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  212. Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report
  213. Coronary artery anomalies: A case of the “malignant” left coronary artery and its surgical management
  214. Combined VAT and retroperitoneoscopy for pleural empyema due to nephro-pleuric fistula in xanthogranulomatous pyelonephritis
  215. 10.1515/med-2025-1362
  216. Rapid Communication
  217. Biological properties of valve materials using RGD and EC
  218. A single oral administration of flavanols enhances short-term memory in mice along with increased brain-derived neurotrophic factor
  219. Letter to the Editor
  220. Role of enhanced external counterpulsation in long COVID
  221. Expression of Concern
  222. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  223. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  224. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  225. Corrigendum
  226. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  227. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  228. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  229. Retraction
  230. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  231. Retraction of: “LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through downregulating SP-A by sponging to miR-424”
  232. Retraction of: “SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways”
  233. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  234. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  235. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  236. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  237. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  238. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  239. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  240. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  241. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  242. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  243. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  244. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  245. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  246. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  247. Red cell distribution width predicts early kidney injury: A NHANES cross-sectional study
  248. Special Issue Diabetes mellitus: pathophysiology, complications & treatment
  249. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  250. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  251. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  252. A review of brain research on T2DM-related cognitive dysfunction
  253. Metformin and estrogen modulation in LABC with T2DM: A 36-month randomized trial
  254. Special Issue Innovative Biomarker Discovery and Precision Medicine in Cancer Diagnostics
  255. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
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Heruntergeladen am 19.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/med-2025-1334/html
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