Startseite Factors influencing spontaneous hypothermia after emergency trauma and the construction of a predictive model
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Factors influencing spontaneous hypothermia after emergency trauma and the construction of a predictive model

  • Xia Feng , Fangxiang Zhu , Anhua Qiao , Wenfang Li , Ying Jiang , Zengtao Han und Lan Dong EMAIL logo
Veröffentlicht/Copyright: 20. April 2024
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Open Life Sciences
Aus der Zeitschrift Open Life Sciences Band 19 Heft 1

Abstract

This study aimed to investigate spontaneous hypothermia among emergency trauma patients and develop a predictive model. A cohort of 162 emergency trauma patients was categorized into hypothermic (n = 61) and control (n = 101) groups, with trauma severity assessed using the modified Glasgow Coma Scale (GCS). Univariate analysis revealed significant differences between the groups in trauma severity, posture, garment wetness, warming measures, pre-hospital fluid resuscitation, and modified GCS scores (P < 0.05). The hypothermic group exhibited lower prothrombin time compared to the control group (P < 0.05). A logistic regression model was constructed, expressed as Y = 25.76 − 1.030X 1 + 0.725X 2 + 0.922X 3 − 0.750X 4 − 0.57X 6, and its fit was evaluated using the Hosmer–Lemeshow test. The receiver operating characteristic curve demonstrated an area under the curve of 0.871, with 81.2% sensitivity and 79.5% specificity. The Youden index identified the optimal predictive cut-off at its highest (0.58). Validation results included 86.21% sensitivity, 82.93% specificity, and 84.29% accuracy. Risk factors for spontaneous hypothermia after emergency trauma encompassed trauma severity, posture during consultation, clothing dampness upon admission, warming measures during transfer, pre-hospital fluid resuscitation, and modified GCS scores. The risk prediction model demonstrated high accuracy, enabling effective assessment of spontaneous hypothermia risk in emergency trauma patients and facilitating preventive measures.

Keywords: emergency trauma; spontaneous hypothermia; influencing factors; predictive model

1 Introduction

Spontaneous hypothermia after trauma is a common complication encountered during the trauma process, with an incidence rate ranging from 12 to 66% [1,2]. Its severity can be categorized into three classes: mild hypothermia (36–34°C), moderate hypothermia (34–32°C), and severe hypothermia (<32°C). The combination of hypothermia, acidosis, and coagulopathy is known as the “lethal triad” in trauma patients, and those who develop spontaneous hypothermia post-trauma have a poorer prognosis [3]. Emergency trauma patients frequently experience spontaneous hypothermia, a potentially fatal complication that can seriously affect the patient’s prognosis and life during resuscitation. Spontaneous hypothermia is defined as a core body temperature below 35°C induced by a variety of conditions, including heat loss, metabolic problems, medication usage, and environmental variables. Spontaneous hypothermia is a major concern for emergency trauma patients that requires adequate care and avoidance. Both domestic and international trauma care guidelines [4,5] emphasize the proactive prevention and treatment of hypothermia following injury. Currently, a significant portion of research conducted both domestically and abroad is centered on investigating the negative consequences associated with spontaneous hypothermia subsequent to trauma.

Nevertheless, the current body of literature regarding the occurrence and determinants of spontaneous hypothermia following acute trauma is very scarce, with a majority of the available studies being retrospective. There exists a conspicuous deficiency in the knowledge and prioritization of post-trauma spontaneous hypothermia among medical and emergency personnel in our nation. The precise occurrence and factors contributing to this phenomenon remain uncertain. Studies indicate that early identification and timely correction of potential patients can effectively improve the prognosis of trauma patients with spontaneous hypothermia, reducing their risk of mortality [6]. However, most existing research focuses on the adverse outcomes associated with spontaneous hypothermia, with limited reports on risk assessment of spontaneous hypothermia post-trauma. Currently, despite the advancements made in the prevention and management of spontaneous hypothermia in emergency trauma patients, several obstacles persist. First, our understanding of the etiology and pathogenesis of spontaneous hypothermia is not deep enough. Second, there are differences in current preventive measures and treatment methods and a lack of consistent guidance and consensus. Hence, it is imperative to undertake additional research endeavors in order to enhance our comprehension of the disease and develop more productive treatment strategies for patients. Therefore, the primary objective of this research is to investigate the underlying mechanism and identify the risk variables associated with spontaneous hypothermia in emergency trauma patients.

Additionally, the study aims to assess the efficacy of current preventive interventions and put forth recommendations for further enhancements. This study aims to establish a robust foundation for clinical practice and policy decision-making, with the ultimate goal of enhancing survival and recovery rates among emergency trauma patients. Moreover, we hope to investigate the components that influence spontaneous hypothermia in patients following emergency trauma and, based on our findings, develop a prediction model to predict its development, which will serve as a reference for clinical intervention.

2 Materials and methods

2.1 Study data

This study employed a cross-sectional study design, with acute trauma patients admitted to our hospital’s emergency department from January 2019 to January 2021. They were thoroughly screened in accordance with the established inclusion criteria, and a temperature of <36°C was selected as the diagnostic basis for hypothermia in trauma patients [7]. Inclusion criteria were age ≥18 years old and complete case data. Exclusion criteria included: suffering from serious diseases before trauma, such as malignant tumors, systemic infections, and severe malnutrition. Sample selection: the case record system and hospitalization database are used to identify patients who align with the inclusion criteria for the study. Data collection: the medical records of all patients included in the study were obtained, and study investigators collected the following data: basic demographic information, characteristics of the emergency trauma, factors contributing to the condition, assessment of its severity, drugs used during therapy, and vital signs recorded throughout hospitalization. The final study sample consisted of a total of 162 emergency trauma patients after excluding 38 subjects based on the predetermined exclusion criteria.

  1. Informed consent: Informed consent has been obtained from all individuals included in this study.

  2. Ethical approval: The research related to human use has been complied with all the relevant national regulations, institutional policies and in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.

2.2 Methods

2.2.1 Trauma assessment

The modified Glasgow Coma Scale (GCS) [8] was used to assess the severity of patient trauma. This encompassed GCS ratings (verbal, eye response, and motor function), respiration, and systolic blood pressure. Scores ranged from 3 to 15, with a lower score indicating heightened trauma severity. Based on the combined scores, trauma patients were categorized into three levels: mild trauma (12–15 points), moderate trauma (7–11 points), and severe trauma (≤6 points).

2.2.2 Data collection

Following a comprehensive examination of relevant literature and the integration of valuable perspectives from medical experts, a questionnaire was developed. It included demographic information such as age; gender; body mass index (BMI); educational level; trauma type, including car accidents, falls from heights, and stab wounds; on-site status: patient’s position at the time of consultation (squatting, lying down, standing, or trapped); measures taken for warming and fluid administration during transit; time taken to reach the emergency room; and post-admission assessments like vital signs, trauma evaluation, and room temperature.

2.2.3 Laboratory examination

The study involved the observation of various coagulation function indicators in patients, including thrombin time (TT), activated partial thromboplastin time (APTT), prothrombin time (PT), antithrombin III (AT-III), fibrinogen (FIB), and D-dimer.

2.2.4 Temperature monitoring

The patient’s body temperature was monitored using a calibrated infrared tympanic thermometer. In situations where the tympanic thermometer is deemed inappropriate, other thermometers like forehead or mercury thermometers are employed.

2.3 Statistical analysis

Collected experimental data were analyzed using SPSS 21.0. After passing the quantitative data, which passed the Kolmogorov–Smirnov test for normality, it was represented by X ± S. Independent sample t-tests were used for comparison between the two groups, while count data were represented as numbers or rates, with χ 2 tests used for intergroup comparison. Variables with significant differences were subjected to multivariate logistic regression analysis, with the Hosmer–Lemeshow test validating the model’s fit. A smaller P-value indicates a poorer fit. Receiver operating characteristic (ROC) curve was plotted to evaluate the applicability of the hypothermia prediction model. A P-value <0.05 was considered statistically significant.

3 Results

3.1 General information of the patients

There were 162 patients included in the study, of which 83 were male and 79 were female. The age range was 20–76 years, with an average of 44.54 ± 11.15 years. Types of injuries included 99 cases of car accidents, 29 cases of high fall injuries, 9 cases of stab wounds, and 25 other cases (Figure 1).

Figure 1 Composition of injury types.
Figure 1

Composition of injury types.

Figure 2 displays the distribution of trauma cases, with 25 cases classified as mild trauma, 107 cases categorized as moderate trauma, and 30 cases designated as severe trauma. Out of the entire cohort, a group of 61 patients exhibited spontaneous hypothermia and were classified as the hypothermic group, whereas a control group consisting of 101 patients without hypothermia was also included.

Figure 2 Distribution of trauma severity.
Figure 2

Distribution of trauma severity.

3.2 Univariate analysis of spontaneous hypothermia after emergency trauma

There were significant discrepancies observed in various factors between the two groups, including the extent of trauma, body position upon admission, wetness of clothing upon admission, warming measures during transfer, pre-hospital fluid administration, and modified GCS score (t = 23.402, 12.113, 4.659, 16.951, 7.778, 10.970; P = 0.000, 0.007, 0.031, 0.000, 0.005, and 0.000, respectively). However, no statistical differences were observed in age, gender, BMI, educational level, type of injury, time taken to reach the emergency room, blood pressure, heart rate, respiration, and emergency room temperature between the two groups. Detailed results are presented in Table 1.

Table 1

Univariate analysis of spontaneous hypothermia after emergency trauma

Variable The hypothermic group (n = 61) The control group (n = 101) t/χ 2 P
Age (years) 45.87 ± 10.26 43.89 ± 10.76 1.155 0.250
Gender
Male 34 48 1.026 0.311
Female 27 53
BMI (kg/m2) 23.48 ± 1.27 23.09 ± 1.36 1.812 0.072
Educational level
High school or below 37 65 0.223 0.637
Bachelor’s degree or below 24 36
Trauma severity
Mild 5 22 23.402 <0.001
Moderate 33 71
Severe 23 8
Type of injury
Car accident injury 34 69 2.599 0.107
Non-car accident injury 27 32
Body position at admission
Crouching 10 5 12.113 0.007
Lying flat 37 85
Standing 8 5
Trapped 6 6
Wetness of clothing upon admission
Yes 31 34 4.659 0.031
No 30 67
Warming measures during transfer
Yes 10 49 16.951 <0.001
No 51 52
Pre-hospital fluid administration
Yes 4 23 7.778 0.005
No 57 74
Time taken to reach the emergency room
<30 min 41 73 0.468 0.494
≥30 min 20 28
Systolic blood pressure (mmHg) 125.95 ± 15.27 128.61 ± 16.18 1.035 0.302
Diastolic blood pressure (mmHg) 75.98 ± 11.76 77.23 ± 12.03 0.646 0.519
Heart rate (beats/min) 85.75 ± 15.43 86.43 ± 15.25 0.274 0.785
Respiration rate (breaths/min) 20.68 ± 3.47 19.84 ± 3.52 1.479 0.141
Emergency room temperature (°C) 23.57 ± 1.68 24.05 ± 1.72 1.736 0.084
The modified GCS score 9.38 ± 1.19 11.82 ± 1.47 10.970 <0.001

3.3 Coagulation function in both patient groups

Compared to the control group, patients in the hypothermia group showed a significant decrease in PT (t = 3.146, P = 0.002). There was no statistically significant difference between the two groups regarding TT, APTT, AT-III, FIB, and D-dimer (Table 2).

Table 2

Coagulation function of both patient groups

Parameter The hypothermic group (n = 61) The control group (n = 101) t P
TT (s) 16.14 ± 0.72 16.33 ± 0.87 1.434 0.153
APTT (s) 26.81 ± 2.89 27.54 ± 2.68 1.631 0.105
PT (s) 7.33 ± 0.72 7.74 ± 0.85 3.146 0.002
AT-Ⅲ (%) 97.29 ± 3.32 96.68 ± 2.57 1.309 0.192
FIB (g/L) 6.05 ± 0.62 5.87 ± 0.53 1.963 0.051
D-dimer (mg/L) 0.57 ± 0.12 0.54 ± 0.13 1.464 0.145

3.4 Establishment of the spontaneous hypothermia prediction model

A logistic regression analysis was performed, with the occurrence of post-emergency trauma hypothermia in patients as the dependent variable, classified as “Yes” (1) or “No” (0). Independent variables were selected based on substantial differences observed in univariate comparisons (Table 3). The results revealed that trauma severity (X 1), body position at consultation (X 2), wet clothing upon admission (X 3), warming measures taken during transfer (X 4), pre-hospital fluid administration (X 5), and the modified GCS score (X 6) were correlated with the occurrence of post-emergency trauma spontaneous hypothermia. The predictive model is given by Y = 25.76 − 1.030X 1 + 0.725X 2 + 0.922X 3 − 0.750X 4 − 0.57X 6 (Table 4).

Table 3

Assignment of independent variables

Independent variable Assignment
Trauma severity (X 1) Mild = 1, moderate = 2, severe = 3
Body position at consultation (X 2) Lying flat = 1, standing = 2, trapped = 3, crouching = 4
Wet clothing upon admission (X 3) Yes = 1, No = 2
Warming measures taken during transfer (X 4) Yes = 1, No = 2
Pre-hospital fluid administration (X 5) Yes = 1, No = 2
The modified GCS score (X 6) ≤6 points = 1, 7–11 points = 2, 12–15 points = 3
Table 4

Results of the logistic regression analysis

Variable β SE Ward P OR 95% CI
Trauma severity (X 1) −1.030 0.348 8.760 0.002 0.357 0.180–0.706
Body position at consultation (X 2) 0.725 0.287 6.383 <0.001 2.065 1.176–3.624
Wet clothing on admission (X 3) 0.922 0.332 7.723 <0.001 2.516 1.312–4.822
Warming measures during transport (X 4) −0.750 0.339 4.904 0.008 0.472 0.242–0.917
Pre-hospital fluid resuscitation (X 5) −0.709 0.324 4.792 <0.001 0.492 0.260–0.928
The modified GCS score (X 6) −0.556 0.247 5.082 0.013 0.573 0.353–0.929
Constant 25.76 5.64 10.376 0.022 — —

3.5 Prediction model fitting and prediction performance

The Hosmer–Lemeshow test was used to validate the prediction model’s fit, and the resultant P-value was 0.125. The ROC curve for the model’s prediction of spontaneous hypothermia was plotted to assess its sensitivity and specificity further. The area under the ROC curve was determined to be 0.871, with a sensitivity of 81.2% and a specificity of 79.5% when the Youden Index’s highest value (0.58) was used as the prediction model’s threshold (Figure 3).

Figure 3 ROC curve for predicting spontaneous hypothermia after emergency trauma.
Figure 3

ROC curve for predicting spontaneous hypothermia after emergency trauma.

3.6 Validation of the spontaneous hypothermia risk prediction model

In the year 2022, a sample of 70 emergency trauma patients was selected randomly in order to assess and validate the effectiveness of the model’s application. A total of 29 instances of spontaneous hypothermia were observed, while the predictive model accurately identified this condition in 25 cases. However, there were four cases in which the model made incorrect predictions. Consequently, the sensitivity of the model, which measures its ability to identify cases of spontaneous hypothermia correctly, was determined to be 86.21%. In instances where spontaneous hypothermia did not occur (41 cases), the model predicted 34 cases, misjudging 7 cases, with a specificity of 82.93%. The overall accuracy rate of the model prediction was (25 + 34)/70 = 84.29% (Table 5).

Table 5

Validation of spontaneous hypothermia risk prediction model (n, %)

Method Number of cases Spontaneous hypothermia No hypothermia
Model prediction 70 25 (35.71) 34 (48.57)
Actual diagnosis 70 29 (41.43) 41 (58.57)

4 Discussion

The occurrence of spontaneous hypothermia in emergency patients has the potential to inhibit coagulation-related enzyme-linked processes, hence impacting platelet function. Acidosis is correlated with reduced body temperature and blood loss due to its potential to induce vasoconstriction, hence contributing to metabolic dysfunction and facilitating the buildup of lactic acid [9]. Therefore, the rapid screening and timely correction of hypothermia are crucial. Nevertheless, as a result of the intricate nature of trauma situations and the unpredictability of trauma locations, precisely and promptly determining the actual body temperature of emergency trauma patients poses a significant challenge. The current instruments utilized for evaluating the risk of hypothermia demonstrate a lack of specificity. Consequently, there is a necessity to develop a predictive model for the occurrence of spontaneous hypothermia following a traumatic event.

In this study, the incidence rate of spontaneous hypothermia in the patients used for modeling was 37.65%, which is consistent with related literature [10–12]. Most of these were victims of car accidents, with a majority presenting with moderate injuries. Factors influencing the onset of hypothermia post-trauma include sociodemographic, environmental factors, pre-hospital emergency care, the trauma itself, and iatrogenic factors [13,14]. Univariate analysis in this study revealed that the severity of trauma, the patient’s position during consultation, damp clothing upon admission, warming measures taken during transfer, pre-hospital fluid administration, and the modified GCS score are significant factors influencing the onset of spontaneous hypothermia.

The more severe the trauma, the more the blood loss, leading to reductions in peripheral blood volume and hemoglobin concentration. This exacerbates cerebral tissue hypoxia and ischemia, affecting the central nervous system’s ability to regulate core temperature, leading to hypothermia. The modified GCS score also decreases accordingly [15,16]. The use of a supine position during the consultation has been observed as showing a higher likelihood of being associated with hypothermia, potentially attributable to the lower temperature of the ground surface. This particular posture enhances the surface area of contact between the patient and the ground, hence facilitating the process of heat loss.

Moreover, emergency patients in the supine position often have varying levels of consciousness impairment; their thermoregulation center might be inhibited by trauma, suppressing heat production [17,18]. The use of crucial warming interventions during the process of transfer, such as the utilization of blankets or quilts for insulation or the administration of warming fluids, can effectively mitigate the risk of hypothermia. Following an accident, the body’s reactive reaction may exhibit a reduction, particularly in cases of severe injuries where skin damage might compromise insulation and expedite heat loss. Therefore, early warmth, moisture isolation, and prevention of heat loss are essential to maintain the patient’s temperature [19,20].

The multivariate logistic regression analysis conducted for this study revealed the following factors as predictors of the risk of post-trauma spontaneous hypothermia: trauma severity (X 1), body position at consultation (X 2), wet clothing upon admission (X 3), pre-hospital fluid administration (X 5), and the modified GCS score (X 6). The predictive model is Y = 25.76 − 1.030X 1 + 0.725X 2 + 0.922X 3 − 0.750X 4 − 0.57X 6 and has been validated with satisfactory fitting effects. One of the factors to consider is the level of trauma experienced (X 1): a substantial association is present between the severity of trauma and the incidence of spontaneous hypothermia among individuals receiving emergency trauma care. Severe trauma has the potential to induce enhanced heat loss and metabolic irregularities inside the body, consequently impacting the functionality of the thermoregulatory system. Furthermore, trauma can cause inflammatory reactions and the production of stress hormones, which can further disrupt body temperature control and increase the risk of spontaneous hypothermia. Position during medical treatment (X 2): position is significant in the development of spontaneous hypothermia in emergency trauma patients. Hypothermia can occur in patients who are positioned in supine or other constrained postures due to limitations imposed by the surrounding environment, which can impede air circulation and result in heat loss.

Furthermore, it should be noted that specific body positions can also give rise to complications such as inadequate blood flow, muscular constriction, and nerve compression, impeding the regular processes of heat production and control. Wet clothing upon admission (X 3): wet clothing can increase heat conduction and accelerate body temperature loss. Exposure of patients to a humid environment during injury or transportation can lead to a more rapid decline in body temperature due to the presence of moist clothing. Moreover, it is worth noting that surroundings with high humidity have the potential to readily induce infections and inflammatory responses, thus exacerbating the disruption of body temperature regulation. Taking warm measures during transportation (X 4): emergency trauma patients may significantly reduce the likelihood of developing spontaneous hypothermia by implementing suitable warm-up protocols. Heating measures may consist of the provision of insulated sheets, the use of heating apparatus, and the lending of appropriate attire. These measures contribute to the elevation of the patient’s body temperature and the production of heat. Pre-hospital infusion (X 5): pre-hospital infusion also has a significant impact on the occurrence of spontaneous hypothermia in emergency trauma patients. Blood volume may increase as a result of excessive infusion, thereby augmenting the area for heat dissipation and heat loss.

Furthermore, low-temperature liquid infusion during the infusion procedure may result in an additional decrease in body temperature for the patient. Revised GCS score (X 6): patients who have experienced emergency trauma are frequently assessed for neurological function using the revised GCS. The body’s ability to perceive and regulate temperature may be impacted by neurological dysfunction, which is typically linked to lower corrected GCS scores. Consequently, among emergency trauma patients, a lower modified GCS score may be associated with a higher likelihood of spontaneous hypothermia. Although there are limited related reports, this model can aid in identifying trauma patients at risk for hypothermia and implementing targeted preventive measures, such as focusing on patients with moderate-to-severe trauma or those in prone positions and actively warming them during transfers. This model can help identify high-risk patients in order to take timely preventive measures and improve patient care. It can be integrated into the workflow of the emergency room to improve the efficiency of patient monitoring and care. However, this model may have limitations, such as limited predictive ability for events within a short time window. Meanwhile, potential directions for improving the model are proposed, such as adding more relevant variables or optimizing algorithms to improve accuracy and practicality. The prediction results based on this model can revise the pre admission and upon admission patient care guidelines of hospitals, and promote their promotion and application in emergency rooms and other medical institutions. More relevant research should be conducted in the future to improve the model and expand its application scope. For example, exploring its applicability in different populations or environments, verifying its accuracy and effectiveness, etc.

5 Conclusion

In conclusion, the current investigation performed univariate and multivariate logistic regression analysis to identify six primary risk factors associated with spontaneous hypothermia in emergency trauma patients. These risk factors include trauma severity, body position during treatment, wet clothing upon admission, measures implemented to preserve warmth during transportation, pre-hospital infusion, and correction of GCS scores. Additionally, this study developed hypothermia risk prediction models based on these identified risk factors. The model has been empirically validated to possess robust prediction capabilities and substantial therapeutic value. The present study has successfully validated a hypothermia risk prediction model and has shown its commendable predictive capability. This model can be of substantial use to clinical practitioners in evaluating the risk and devising preventive strategies for emergency trauma patients. The prompt discusses the need to promptly identify patients who are at high risk for adverse outcomes and implement appropriate measures.

# Xia Feng and Fangxiang Zhu have made equal contributions to the research.

  1. Funding information: Authors state no funding involved.

  2. Author contributions: X.F.: Conceptualization, Methodology, Writing-Original draft preparation, Visualization, Investigation, Supervision; F.Z.: Conceptualization, Methodology, Writing-Original draft preparation, Visualization, Investigation, Supervision; A.Q.: Software, Data curation, Writing-Original draft preparation; W.L.: Visualization, Investigation, Writing-Original draft preparation; Y.J.: Software, Data curation; Z.H.: Methodology, Visualization; L.D.: Conceptualization, Methodology, Investigation, Writing-Reviewing and Editing.

  3. Conflict of interest: Authors state no conflict of interest.

  4. Data availability statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

[1] Hemelsoet DM, De Bleecker JL. Post‐traumatic spontaneous recurrent hypothermia: a variant of Shapiro’s syndrome. Eur J Neurol. 2007;14(2):224–7.10.1111/j.1468-1331.2006.01609.xSuche in Google Scholar PubMed

[2] Ruiz C, Gener B, Garaizar C, Prats JM. Episodic spontaneous hypothermia: a periodic childhood syndrome. Pediatr Neurol. 2003;28(4):304–6.10.1016/S0887-8994(02)00631-8Suche in Google Scholar PubMed

[3] Rincon F, Hunter K, Schorr C, Dellinger RP, Zanotti-Cavazzoni S. The epidemiology of spontaneous fever and hypothermia on admission of brain injury patients to intensive care units: a multicenter cohort study. J Neurosurg. 2014;121(4):950–60.10.3171/2014.7.JNS132470Suche in Google Scholar PubMed

[4] Crompton EM, Lubomirova I, Cotlarciuc I, Han TS, Sharma SD, Sharma P. Meta-analysis of therapeutic hypothermia for traumatic brain injury in adult and pediatric patients. Crit Care Med. 2017;45(4):575–83.10.1097/CCM.0000000000002205Suche in Google Scholar PubMed

[5] Lee KR, Chung SP, Park IC, Kim SH. Effect of induced and spontaneous hypothermia on survival time of uncontrolled hemorrhagic shock rat model. Yonsei Med J. 2002;43(4):511–7.10.3349/ymj.2002.43.4.511Suche in Google Scholar PubMed

[6] Podsiadło P, Smoleń A, Brožek T, Kosiński S, Balik M, Hymczak H, et al. Extracorporeal rewarming is associated with increased survival rate in severely hypothermic patients with preserved spontaneous circulation. ASAIO J. 2023;69(8):749–55.10.1097/MAT.0000000000001935Suche in Google Scholar PubMed

[7] Kämäräinen A, Hoppu S, Silfvast T, Virkkunen I. Pre-hospital therapeutic hypothermia after cardiac arrest-from current concepts to a future standard. ScJ Trauma Resuscitation Emerg Med. 2009;17:1–6.10.1186/1757-7241-17-53Suche in Google Scholar PubMed PubMed Central

[8] Osler T, Cook A, Glance LG, Lecky F, Bouamra O, Garrett M, et al. The differential mortality of Glasgow Coma Score in patients with and without head injury. Injury. 2016;47(9):1879–85.10.1016/j.injury.2016.04.016Suche in Google Scholar PubMed

[9] Alberca RW, Gomes E, Moretti EH, Russo M, Steiner AA. Naturally occurring hypothermia promotes survival in severe anaphylaxis. Immunol Lett. 2021;237:27–32.10.1016/j.imlet.2021.07.002Suche in Google Scholar PubMed

[10] Ferguson KM, Fyfe T, Montgomery J. A case of spontaneous hypothermia. Scott Med J. 1992;37(3):85–6.10.1177/003693309203700308Suche in Google Scholar PubMed

[11] Cho HJ, Kyong YY, Oh YM, Choi SM, Choi KH, Oh JS. Therapeutic hypothermia complicated by spontaneous brain stem hemorrhage. Am J Emerg Med. 2013;31(1):266.e1–3.10.1016/j.ajem.2012.04.017Suche in Google Scholar PubMed

[12] Zhou M, Wang P, Yang Z, Wu H, Huan Z. Spontaneous hypothermia ameliorated inflammation and neurologic deficit in rat cardiac arrest models following resuscitation. Mol Med Rep. 2018;17(2):2127–36.10.3892/mmr.2017.8113Suche in Google Scholar PubMed PubMed Central

[13] Rodrigues Masruha MA, Lin J, Arita JH, de Castro Neto EF, Scerni DA, Cavalheiro EA, et al. Spontaneous periodic hypothermia and hyperhidrosis: a possibly novel cerebral neurotransmitter disorder. Dev Med Child Neurol. 2011;53(4):378–80.10.1111/j.1469-8749.2010.03854.xSuche in Google Scholar PubMed

[14] Aubignat M, Tir M, Krystkowiak P, Andriuta D. Episodic headache with spontaneous hypothermia reveal Shapiro’s syndrome variant with effectiveness of clonidine therapy. J Headache Pain. 2021;22(1):30.10.1186/s10194-021-01245-3Suche in Google Scholar PubMed PubMed Central

[15] Wu X, Stezoski J, Safar P, Nozari A, Tisherman SA. After spontaneous hypothermia during hemorrhagic shock, continuing mild hypothermia (34°C) improves early but not late survival in rats. J Trauma Acute Care Surg. 2003;55(2):308–16.10.1097/01.TA.0000079366.23533.1ESuche in Google Scholar PubMed

[16] Takagi K, Tsuchiya Y, Okinaga K, Hirata M, Nakagomi T, Tamura A. Natural hypothermia immediately after transient global cerebral ischemia induced by spontaneous subarachnoid hemorrhage. J Neurosurg. 2003;98(1):50–6.10.3171/jns.2003.98.1.0050Suche in Google Scholar PubMed

[17] Wörner J, Oddo M. Too cold may not be so cool: spontaneous hypothermia as a marker of poor outcome after cardiac arrest. Crit Care. 2010;14(5):1–2.10.1186/cc9270Suche in Google Scholar PubMed PubMed Central

[18] den Hartog AW, de Pont AC, Robillard LB, Binnekade JM, Schultz MJ, Horn J. Spontaneous hypothermia on intensive care unit admission is a predictor of unfavorable neurological outcome in patients after resuscitation: an observational cohort study. Crit Care. 2010;14:1–5.10.1186/cc9077Suche in Google Scholar PubMed PubMed Central

[19] Rubiano AM, Sanchez AI, Estebanez G, Peitzman A, Sperry J, Puyana JC. The effect of admission spontaneous hypothermia on patients with severe traumatic brain injury. Injury. 2013;44(9):1219–25.10.1016/j.injury.2012.11.026Suche in Google Scholar PubMed PubMed Central

[20] Vinetti M, Duprez T, Lawson TM, Vanthuyne V, Hantson P. Spontaneous periodic hypothermia in the postoperative phase of a brain tumor of the third ventricle. Acta Neurol Belg. 2015;115:753–5.10.1007/s13760-015-0430-3Suche in Google Scholar PubMed

Received: 2023-09-08
Revised: 2024-03-12
Accepted: 2024-03-19
Published Online: 2024-04-20

© 2024 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  18. Current research and evidence gaps on placental development in iron deficiency anemia
  19. Single-nucleotide polymorphism rs2910829 in PDE4D is related to stroke susceptibility in Chinese populations: The results of a meta-analysis
  20. Pheochromocytoma-induced myocardial infarction: A case report
  21. Kaempferol regulates apoptosis and migration of neural stem cells to attenuate cerebral infarction by O‐GlcNAcylation of β-catenin
  22. Sirtuin 5 regulates acute myeloid leukemia cell viability and apoptosis by succinylation modification of glycine decarboxylase
  23. Apigenin 7-glucoside impedes hypoxia-induced malignant phenotypes of cervical cancer cells in a p16-dependent manner
  24. KAT2A changes the function of endometrial stromal cells via regulating the succinylation of ENO1
  25. Current state of research on copper complexes in the treatment of breast cancer
  26. Exploring antioxidant strategies in the pathogenesis of ALS
  27. Helicobacter pylori causes gastric dysbacteriosis in chronic gastritis patients
  28. IL-33/soluble ST2 axis is associated with radiation-induced cardiac injury
  29. The predictive value of serum NLR, SII, and OPNI for lymph node metastasis in breast cancer patients with internal mammary lymph nodes after thoracoscopic surgery
  30. Carrying SNP rs17506395 (T > G) in TP63 gene and CCR5Δ32 mutation associated with the occurrence of breast cancer in Burkina Faso
  31. P2X7 receptor: A receptor closely linked with sepsis-associated encephalopathy
  32. Probiotics for inflammatory bowel disease: Is there sufficient evidence?
  33. Identification of KDM4C as a gene conferring drug resistance in multiple myeloma
  34. Microbial perspective on the skin–gut axis and atopic dermatitis
  35. Thymosin α1 combined with XELOX improves immune function and reduces serum tumor markers in colorectal cancer patients after radical surgery
  36. Highly specific vaginal microbiome signature for gynecological cancers
  37. Sample size estimation for AQP4-IgG seropositive optic neuritis: Retinal damage detection by optical coherence tomography
  38. The effects of SDF-1 combined application with VEGF on femoral distraction osteogenesis in rats
  39. Fabrication and characterization of gold nanoparticles using alginate: In vitro and in vivo assessment of its administration effects with swimming exercise on diabetic rats
  40. Mitigating digestive disorders: Action mechanisms of Mediterranean herbal active compounds
  41. Distribution of CYP2D6 and CYP2C19 gene polymorphisms in Han and Uygur populations with breast cancer in Xinjiang, China
  42. VSP-2 attenuates secretion of inflammatory cytokines induced by LPS in BV2 cells by mediating the PPARγ/NF-κB signaling pathway
  43. Factors influencing spontaneous hypothermia after emergency trauma and the construction of a predictive model
  44. Long-term administration of morphine specifically alters the level of protein expression in different brain regions and affects the redox state
  45. Application of metagenomic next-generation sequencing technology in the etiological diagnosis of peritoneal dialysis-associated peritonitis
  46. Clinical diagnosis, prevention, and treatment of neurodyspepsia syndrome using intelligent medicine
  47. Case report: Successful bronchoscopic interventional treatment of endobronchial leiomyomas
  48. Preliminary investigation into the genetic etiology of short stature in children through whole exon sequencing of the core family
  49. Cystic adenomyoma of the uterus: Case report and literature review
  50. Mesoporous silica nanoparticles as a drug delivery mechanism
  51. Dynamic changes in autophagy activity in different degrees of pulmonary fibrosis in mice
  52. Vitamin D deficiency and inflammatory markers in type 2 diabetes: Big data insights
  53. Lactate-induced IGF1R protein lactylation promotes proliferation and metabolic reprogramming of lung cancer cells
  54. Meta-analysis on the efficacy of allogeneic hematopoietic stem cell transplantation to treat malignant lymphoma
  55. Mitochondrial DNA drives neuroinflammation through the cGAS-IFN signaling pathway in the spinal cord of neuropathic pain mice
  56. Application value of artificial intelligence algorithm-based magnetic resonance multi-sequence imaging in staging diagnosis of cervical cancer
  57. Embedded monitoring system and teaching of artificial intelligence online drug component recognition
  58. Investigation into the association of FNDC1 and ADAMTS12 gene expression with plumage coloration in Muscovy ducks
  59. Yak meat content in feed and its impact on the growth of rats
  60. A rare case of Richter transformation with breast involvement: A case report and literature review
  61. First report of Nocardia wallacei infection in an immunocompetent patient in Zhejiang province
  62. Rhodococcus equi and Brucella pulmonary mass in immunocompetent: A case report and literature review
  63. Downregulation of RIP3 ameliorates the left ventricular mechanics and function after myocardial infarction via modulating NF-κB/NLRP3 pathway
  64. Evaluation of the role of some non-enzymatic antioxidants among Iraqi patients with non-alcoholic fatty liver disease
  65. The role of Phafin proteins in cell signaling pathways and diseases
  66. Ten-year anemia as initial manifestation of Castleman disease in the abdominal cavity: A case report
  67. Coexistence of hereditary spherocytosis with SPTB P.Trp1150 gene variant and Gilbert syndrome: A case report and literature review
  68. Utilization of convolutional neural networks to analyze microscopic images for high-throughput screening of mesenchymal stem cells
  69. Exploratory evaluation supported by experimental and modeling approaches of Inula viscosa root extract as a potent corrosion inhibitor for mild steel in a 1 M HCl solution
  70. Imaging manifestations of ductal adenoma of the breast: A case report
  71. Gut microbiota and sleep: Interaction mechanisms and therapeutic prospects
  72. Isomangiferin promotes the migration and osteogenic differentiation of rat bone marrow mesenchymal stem cells
  73. Prognostic value and microenvironmental crosstalk of exosome-related signatures in human epidermal growth factor receptor 2 positive breast cancer
  74. Circular RNAs as potential biomarkers for male severe sepsis
  75. Knockdown of Stanniocalcin-1 inhibits growth and glycolysis in oral squamous cell carcinoma cells
  76. The expression and biological role of complement C1s in esophageal squamous cell carcinoma
  77. A novel GNAS mutation in pseudohypoparathyroidism type 1a with articular flexion deformity: A case report
  78. Predictive value of serum magnesium levels for prognosis in patients with non-small cell lung cancer undergoing EGFR-TKI therapy
  79. HSPB1 alleviates acute-on-chronic liver failure via the P53/Bax pathway
  80. IgG4-related disease complicated by PLA2R-associated membranous nephropathy: A case report
  81. Baculovirus-mediated endostatin and angiostatin activation of autophagy through the AMPK/AKT/mTOR pathway inhibits angiogenesis in hepatocellular carcinoma
  82. Metformin mitigates osteoarthritis progression by modulating the PI3K/AKT/mTOR signaling pathway and enhancing chondrocyte autophagy
  83. Evaluation of the activity of antimicrobial peptides against bacterial vaginosis
  84. Atypical presentation of γ/δ mycosis fungoides with an unusual phenotype and SOCS1 mutation
  85. Analysis of the microecological mechanism of diabetic kidney disease based on the theory of “gut–kidney axis”: A systematic review
  86. Omega-3 fatty acids prevent gestational diabetes mellitus via modulation of lipid metabolism
  87. Refractory hypertension complicated with Turner syndrome: A case report
  88. Interaction of ncRNAs and the PI3K/AKT/mTOR pathway: Implications for osteosarcoma
  89. Association of low attenuation area scores with pulmonary function and clinical prognosis in patients with chronic obstructive pulmonary disease
  90. Long non-coding RNAs in bone formation: Key regulators and therapeutic prospects
  91. The deubiquitinating enzyme USP35 regulates the stability of NRF2 protein
  92. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential diagnostic markers for rebleeding in patients with esophagogastric variceal bleeding
  93. G protein-coupled receptor 1 participating in the mechanism of mediating gestational diabetes mellitus by phosphorylating the AKT pathway
  94. LL37-mtDNA regulates viability, apoptosis, inflammation, and autophagy in lipopolysaccharide-treated RLE-6TN cells by targeting Hsp90aa1
  95. The analgesic effect of paeoniflorin: A focused review
  96. Chemical composition’s effect on Solanum nigrum Linn.’s antioxidant capacity and erythrocyte protection: Bioactive components and molecular docking analysis
  97. Knockdown of HCK promotes HREC cell viability and inner blood–retinal barrier integrity by regulating the AMPK signaling pathway
  98. The role of rapamycin in the PINK1/Parkin signaling pathway in mitophagy in podocytes
  99. Laryngeal non-Hodgkin lymphoma: Report of four cases and review of the literature
  100. Clinical value of macrogenome next-generation sequencing on infections
  101. Overview of dendritic cells and related pathways in autoimmune uveitis
  102. TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway
  103. Hypomethylation in promoters of PGC-1α involved in exercise-driven skeletal muscular alterations in old age
  104. Profile and antimicrobial susceptibility patterns of bacteria isolated from effluents of Kolladiba and Debark hospitals
  105. The expression and clinical significance of syncytin-1 in serum exosomes of hepatocellular carcinoma patients
  106. A histomorphometric study to evaluate the therapeutic effects of biosynthesized silver nanoparticles on the kidneys infected with Plasmodium chabaudi
  107. PGRMC1 and PAQR4 are promising molecular targets for a rare subtype of ovarian cancer
  108. Analysis of MDA, SOD, TAOC, MNCV, SNCV, and TSS scores in patients with diabetes peripheral neuropathy
  109. SLIT3 deficiency promotes non-small cell lung cancer progression by modulating UBE2C/WNT signaling
  110. The relationship between TMCO1 and CALR in the pathological characteristics of prostate cancer and its effect on the metastasis of prostate cancer cells
  111. Heterogeneous nuclear ribonucleoprotein K is a potential target for enhancing the chemosensitivity of nasopharyngeal carcinoma
  112. PHB2 alleviates retinal pigment epithelium cell fibrosis by suppressing the AGE–RAGE pathway
  113. Anti-γ-aminobutyric acid-B receptor autoimmune encephalitis with syncope as the initial symptom: Case report and literature review
  114. Comparative analysis of chloroplast genome of Lonicera japonica cv. Damaohua
  115. Human umbilical cord mesenchymal stem cells regulate glutathione metabolism depending on the ERK–Nrf2–HO-1 signal pathway to repair phosphoramide mustard-induced ovarian cancer cells
  116. Electroacupuncture on GB acupoints improves osteoporosis via the estradiol–PI3K–Akt signaling pathway
  117. Renalase protects against podocyte injury by inhibiting oxidative stress and apoptosis in diabetic nephropathy
  118. Review: Dicranostigma leptopodum: A peculiar plant of Papaveraceae
  119. Combination effect of flavonoids attenuates lung cancer cell proliferation by inhibiting the STAT3 and FAK signaling pathway
  120. Renal microangiopathy and immune complex glomerulonephritis induced by anti-tumour agents: A case report
  121. Correlation analysis of AVPR1a and AVPR2 with abnormal water and sodium and potassium metabolism in rats
  122. Gastrointestinal health anti-diarrheal mixture relieves spleen deficiency-induced diarrhea through regulating gut microbiota
  123. Myriad factors and pathways influencing tumor radiotherapy resistance
  124. Exploring the effects of culture conditions on Yapsin (YPS) gene expression in Nakaseomyces glabratus
  125. Screening of prognostic core genes based on cell–cell interaction in the peripheral blood of patients with sepsis
  126. Coagulation factor II thrombin receptor as a promising biomarker in breast cancer management
  127. Ileocecal mucinous carcinoma misdiagnosed as incarcerated hernia: A case report
  128. Methyltransferase like 13 promotes malignant behaviors of bladder cancer cells through targeting PI3K/ATK signaling pathway
  129. The debate between electricity and heat, efficacy and safety of irreversible electroporation and radiofrequency ablation in the treatment of liver cancer: A meta-analysis
  130. ZAG promotes colorectal cancer cell proliferation and epithelial–mesenchymal transition by promoting lipid synthesis
  131. Baicalein inhibits NLRP3 inflammasome activation and mitigates placental inflammation and oxidative stress in gestational diabetes mellitus
  132. Impact of SWCNT-conjugated senna leaf extract on breast cancer cells: A potential apoptotic therapeutic strategy
  133. MFAP5 inhibits the malignant progression of endometrial cancer cells in vitro
  134. Major ozonated autohemotherapy promoted functional recovery following spinal cord injury in adult rats via the inhibition of oxidative stress and inflammation
  135. Axodendritic targeting of TAU and MAP2 and microtubule polarization in iPSC-derived versus SH-SY5Y-derived human neurons
  136. Differential expression of phosphoinositide 3-kinase/protein kinase B and Toll-like receptor/nuclear factor kappa B signaling pathways in experimental obesity Wistar rat model
  137. The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review
  138. BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis
  139. Role of circRMRP and circRPL27 in chronic obstructive pulmonary disease
  140. Investigating the role of hyperexpressed HCN1 in inducing myocardial infarction through activation of the NF-κB signaling pathway
  141. Characterization of phenolic compounds and evaluation of anti-diabetic potential in Cannabis sativa L. seeds: In vivo, in vitro, and in silico studies
  142. Quantitative immunohistochemistry analysis of breast Ki67 based on artificial intelligence
  143. Ecology and Environmental Science
  144. Screening of different growth conditions of Bacillus subtilis isolated from membrane-less microbial fuel cell toward antimicrobial activity profiling
  145. Degradation of a mixture of 13 polycyclic aromatic hydrocarbons by commercial effective microorganisms
  146. Evaluation of the impact of two citrus plants on the variation of Panonychus citri (Acari: Tetranychidae) and beneficial phytoseiid mites
  147. Prediction of present and future distribution areas of Juniperus drupacea Labill and determination of ethnobotany properties in Antalya Province, Türkiye
  148. Population genetics of Todarodes pacificus (Cephalopoda: Ommastrephidae) in the northwest Pacific Ocean via GBS sequencing
  149. A comparative analysis of dendrometric, macromorphological, and micromorphological characteristics of Pistacia atlantica subsp. atlantica and Pistacia terebinthus in the middle Atlas region of Morocco
  150. Macrofungal sporocarp community in the lichen Scots pine forests
  151. Assessing the proximate compositions of indigenous forage species in Yemen’s pastoral rangelands
  152. Food Science
  153. Gut microbiota changes associated with low-carbohydrate diet intervention for obesity
  154. Reexamination of Aspergillus cristatus phylogeny in dark tea: Characteristics of the mitochondrial genome
  155. Differences in the flavonoid composition of the leaves, fruits, and branches of mulberry are distinguished based on a plant metabolomics approach
  156. Investigating the impact of wet rendering (solventless method) on PUFA-rich oil from catfish (Clarias magur) viscera
  157. Non-linear associations between cardiovascular metabolic indices and metabolic-associated fatty liver disease: A cross-sectional study in the US population (2017–2020)
  158. Knockdown of USP7 alleviates atherosclerosis in ApoE-deficient mice by regulating EZH2 expression
  159. Utility of dairy microbiome as a tool for authentication and traceability
  160. Agriculture
  161. Enhancing faba bean (Vicia faba L.) productivity through establishing the area-specific fertilizer rate recommendation in southwest Ethiopia
  162. Impact of novel herbicide based on synthetic auxins and ALS inhibitor on weed control
  163. Perspectives of pteridophytes microbiome for bioremediation in agricultural applications
  164. Fertilizer application parameters for drip-irrigated peanut based on the fertilizer effect function established from a “3414” field trial
  165. Improving the productivity and profitability of maize (Zea mays L.) using optimum blended inorganic fertilization
  166. Application of leaf multispectral analyzer in comparison to hyperspectral device to assess the diversity of spectral reflectance indices in wheat genotypes
  167. Animal Sciences
  168. Knockdown of ANP32E inhibits colorectal cancer cell growth and glycolysis by regulating the AKT/mTOR pathway
  169. Development of a detection chip for major pathogenic drug-resistant genes and drug targets in bovine respiratory system diseases
  170. Exploration of the genetic influence of MYOT and MB genes on the plumage coloration of Muscovy ducks
  171. Transcriptome analysis of adipose tissue in grazing cattle: Identifying key regulators of fat metabolism
  172. Comparison of nutritional value of the wild and cultivated spiny loaches at three growth stages
  173. Transcriptomic analysis of liver immune response in Chinese spiny frog (Quasipaa spinosa) infected with Proteus mirabilis
  174. Disruption of BCAA degradation is a critical characteristic of diabetic cardiomyopathy revealed by integrated transcriptome and metabolome analysis
  175. Plant Sciences
  176. Effect of long-term in-row branch covering on soil microorganisms in pear orchards
  177. Photosynthetic physiological characteristics, growth performance, and element concentrations reveal the calcicole–calcifuge behaviors of three Camellia species
  178. Transcriptome analysis reveals the mechanism of NaHCO3 promoting tobacco leaf maturation
  179. Bioinformatics, expression analysis, and functional verification of allene oxide synthase gene HvnAOS1 and HvnAOS2 in qingke
  180. Water, nitrogen, and phosphorus coupling improves gray jujube fruit quality and yield
  181. Improving grape fruit quality through soil conditioner: Insights from RNA-seq analysis of Cabernet Sauvignon roots
  182. Role of Embinin in the reabsorption of nucleus pulposus in lumbar disc herniation: Promotion of nucleus pulposus neovascularization and apoptosis of nucleus pulposus cells
  183. Revealing the effects of amino acid, organic acid, and phytohormones on the germination of tomato seeds under salinity stress
  184. Combined effects of nitrogen fertilizer and biochar on the growth, yield, and quality of pepper
  185. Comprehensive phytochemical and toxicological analysis of Chenopodium ambrosioides (L.) fractions
  186. Impact of “3414” fertilization on the yield and quality of greenhouse tomatoes
  187. Exploring the coupling mode of water and fertilizer for improving growth, fruit quality, and yield of the pear in the arid region
  188. Metagenomic analysis of endophytic bacteria in seed potato (Solanum tuberosum)
  189. Antibacterial, antifungal, and phytochemical properties of Salsola kali ethanolic extract
  190. Exploring the hepatoprotective properties of citronellol: In vitro and in silico studies on ethanol-induced damage in HepG2 cells
  191. Enhanced osmotic dehydration of watermelon rind using honey–sucrose solutions: A study on pre-treatment efficacy and mass transfer kinetics
  192. Effects of exogenous 2,4-epibrassinolide on photosynthetic traits of 53 cowpea varieties under NaCl stress
  193. Comparative transcriptome analysis of maize (Zea mays L.) seedlings in response to copper stress
  194. An optimization method for measuring the stomata in cassava (Manihot esculenta Crantz) under multiple abiotic stresses
  195. Fosinopril inhibits Ang II-induced VSMC proliferation, phenotype transformation, migration, and oxidative stress through the TGF-β1/Smad signaling pathway
  196. Antioxidant and antimicrobial activities of Salsola imbricata methanolic extract and its phytochemical characterization
  197. Bioengineering and Biotechnology
  198. Absorbable calcium and phosphorus bioactive membranes promote bone marrow mesenchymal stem cells osteogenic differentiation for bone regeneration
  199. New advances in protein engineering for industrial applications: Key takeaways
  200. An overview of the production and use of Bacillus thuringiensis toxin
  201. Research progress of nanoparticles in diagnosis and treatment of hepatocellular carcinoma
  202. Bioelectrochemical biosensors for water quality assessment and wastewater monitoring
  203. PEI/MMNs@LNA-542 nanoparticles alleviate ICU-acquired weakness through targeted autophagy inhibition and mitochondrial protection
  204. Unleashing of cytotoxic effects of thymoquinone-bovine serum albumin nanoparticles on A549 lung cancer cells
  205. Erratum
  206. Erratum to “Investigating the association between dietary patterns and glycemic control among children and adolescents with T1DM”
  207. Erratum to “Activation of hypermethylated P2RY1 mitigates gastric cancer by promoting apoptosis and inhibiting proliferation”
  208. Retraction
  209. Retraction to “MiR-223-3p regulates cell viability, migration, invasion, and apoptosis of non-small cell lung cancer cells by targeting RHOB”
  210. Retraction to “A data mining technique for detecting malignant mesothelioma cancer using multiple regression analysis”
  211. Special Issue on Advances in Neurodegenerative Disease Research and Treatment
  212. Transplantation of human neural stem cell prevents symptomatic motor behavior disability in a rat model of Parkinson’s disease
  213. Special Issue on Multi-omics
  214. Inflammasome complex genes with clinical relevance suggest potential as therapeutic targets for anti-tumor drugs in clear cell renal cell carcinoma
  215. Gastroesophageal varices in primary biliary cholangitis with anti-centromere antibody positivity: Early onset?
https://doi.org/10.1515/biol-2022-0862
Schlagwörter für diesen Artikel
emergency trauma; spontaneous hypothermia; influencing factors; predictive model
Creative Commons
BY 4.0

Artikel in diesem Heft

  1. Biomedical Sciences
  2. Constitutive and evoked release of ATP in adult mouse olfactory epithelium
  3. LARP1 knockdown inhibits cultured gastric carcinoma cell cycle progression and metastatic behavior
  4. PEGylated porcine–human recombinant uricase: A novel fusion protein with improved efficacy and safety for the treatment of hyperuricemia and renal complications
  5. Research progress on ocular complications caused by type 2 diabetes mellitus and the function of tears and blepharons
  6. The role and mechanism of esketamine in preventing and treating remifentanil-induced hyperalgesia based on the NMDA receptor–CaMKII pathway
  7. Brucella infection combined with Nocardia infection: A case report and literature review
  8. Detection of serum interleukin-18 level and neutrophil/lymphocyte ratio in patients with antineutrophil cytoplasmic antibody-associated vasculitis and its clinical significance
  9. Ang-1, Ang-2, and Tie2 are diagnostic biomarkers for Henoch-Schönlein purpura and pediatric-onset systemic lupus erythematous
  10. PTTG1 induces pancreatic cancer cell proliferation and promotes aerobic glycolysis by regulating c-myc
  11. Role of serum B-cell-activating factor and interleukin-17 as biomarkers in the classification of interstitial pneumonia with autoimmune features
  12. Effectiveness and safety of a mumps containing vaccine in preventing laboratory-confirmed mumps cases from 2002 to 2017: A meta-analysis
  13. Low levels of sex hormone-binding globulin predict an increased breast cancer risk and its underlying molecular mechanisms
  14. A case of Trousseau syndrome: Screening, detection and complication
  15. Application of the integrated airway humidification device enhances the humidification effect of the rabbit tracheotomy model
  16. Preparation of Cu2+/TA/HAP composite coating with anti-bacterial and osteogenic potential on 3D-printed porous Ti alloy scaffolds for orthopedic applications
  17. Aquaporin-8 promotes human dermal fibroblasts to counteract hydrogen peroxide-induced oxidative damage: A novel target for management of skin aging
  18. Current research and evidence gaps on placental development in iron deficiency anemia
  19. Single-nucleotide polymorphism rs2910829 in PDE4D is related to stroke susceptibility in Chinese populations: The results of a meta-analysis
  20. Pheochromocytoma-induced myocardial infarction: A case report
  21. Kaempferol regulates apoptosis and migration of neural stem cells to attenuate cerebral infarction by O‐GlcNAcylation of β-catenin
  22. Sirtuin 5 regulates acute myeloid leukemia cell viability and apoptosis by succinylation modification of glycine decarboxylase
  23. Apigenin 7-glucoside impedes hypoxia-induced malignant phenotypes of cervical cancer cells in a p16-dependent manner
  24. KAT2A changes the function of endometrial stromal cells via regulating the succinylation of ENO1
  25. Current state of research on copper complexes in the treatment of breast cancer
  26. Exploring antioxidant strategies in the pathogenesis of ALS
  27. Helicobacter pylori causes gastric dysbacteriosis in chronic gastritis patients
  28. IL-33/soluble ST2 axis is associated with radiation-induced cardiac injury
  29. The predictive value of serum NLR, SII, and OPNI for lymph node metastasis in breast cancer patients with internal mammary lymph nodes after thoracoscopic surgery
  30. Carrying SNP rs17506395 (T > G) in TP63 gene and CCR5Δ32 mutation associated with the occurrence of breast cancer in Burkina Faso
  31. P2X7 receptor: A receptor closely linked with sepsis-associated encephalopathy
  32. Probiotics for inflammatory bowel disease: Is there sufficient evidence?
  33. Identification of KDM4C as a gene conferring drug resistance in multiple myeloma
  34. Microbial perspective on the skin–gut axis and atopic dermatitis
  35. Thymosin α1 combined with XELOX improves immune function and reduces serum tumor markers in colorectal cancer patients after radical surgery
  36. Highly specific vaginal microbiome signature for gynecological cancers
  37. Sample size estimation for AQP4-IgG seropositive optic neuritis: Retinal damage detection by optical coherence tomography
  38. The effects of SDF-1 combined application with VEGF on femoral distraction osteogenesis in rats
  39. Fabrication and characterization of gold nanoparticles using alginate: In vitro and in vivo assessment of its administration effects with swimming exercise on diabetic rats
  40. Mitigating digestive disorders: Action mechanisms of Mediterranean herbal active compounds
  41. Distribution of CYP2D6 and CYP2C19 gene polymorphisms in Han and Uygur populations with breast cancer in Xinjiang, China
  42. VSP-2 attenuates secretion of inflammatory cytokines induced by LPS in BV2 cells by mediating the PPARγ/NF-κB signaling pathway
  43. Factors influencing spontaneous hypothermia after emergency trauma and the construction of a predictive model
  44. Long-term administration of morphine specifically alters the level of protein expression in different brain regions and affects the redox state
  45. Application of metagenomic next-generation sequencing technology in the etiological diagnosis of peritoneal dialysis-associated peritonitis
  46. Clinical diagnosis, prevention, and treatment of neurodyspepsia syndrome using intelligent medicine
  47. Case report: Successful bronchoscopic interventional treatment of endobronchial leiomyomas
  48. Preliminary investigation into the genetic etiology of short stature in children through whole exon sequencing of the core family
  49. Cystic adenomyoma of the uterus: Case report and literature review
  50. Mesoporous silica nanoparticles as a drug delivery mechanism
  51. Dynamic changes in autophagy activity in different degrees of pulmonary fibrosis in mice
  52. Vitamin D deficiency and inflammatory markers in type 2 diabetes: Big data insights
  53. Lactate-induced IGF1R protein lactylation promotes proliferation and metabolic reprogramming of lung cancer cells
  54. Meta-analysis on the efficacy of allogeneic hematopoietic stem cell transplantation to treat malignant lymphoma
  55. Mitochondrial DNA drives neuroinflammation through the cGAS-IFN signaling pathway in the spinal cord of neuropathic pain mice
  56. Application value of artificial intelligence algorithm-based magnetic resonance multi-sequence imaging in staging diagnosis of cervical cancer
  57. Embedded monitoring system and teaching of artificial intelligence online drug component recognition
  58. Investigation into the association of FNDC1 and ADAMTS12 gene expression with plumage coloration in Muscovy ducks
  59. Yak meat content in feed and its impact on the growth of rats
  60. A rare case of Richter transformation with breast involvement: A case report and literature review
  61. First report of Nocardia wallacei infection in an immunocompetent patient in Zhejiang province
  62. Rhodococcus equi and Brucella pulmonary mass in immunocompetent: A case report and literature review
  63. Downregulation of RIP3 ameliorates the left ventricular mechanics and function after myocardial infarction via modulating NF-κB/NLRP3 pathway
  64. Evaluation of the role of some non-enzymatic antioxidants among Iraqi patients with non-alcoholic fatty liver disease
  65. The role of Phafin proteins in cell signaling pathways and diseases
  66. Ten-year anemia as initial manifestation of Castleman disease in the abdominal cavity: A case report
  67. Coexistence of hereditary spherocytosis with SPTB P.Trp1150 gene variant and Gilbert syndrome: A case report and literature review
  68. Utilization of convolutional neural networks to analyze microscopic images for high-throughput screening of mesenchymal stem cells
  69. Exploratory evaluation supported by experimental and modeling approaches of Inula viscosa root extract as a potent corrosion inhibitor for mild steel in a 1 M HCl solution
  70. Imaging manifestations of ductal adenoma of the breast: A case report
  71. Gut microbiota and sleep: Interaction mechanisms and therapeutic prospects
  72. Isomangiferin promotes the migration and osteogenic differentiation of rat bone marrow mesenchymal stem cells
  73. Prognostic value and microenvironmental crosstalk of exosome-related signatures in human epidermal growth factor receptor 2 positive breast cancer
  74. Circular RNAs as potential biomarkers for male severe sepsis
  75. Knockdown of Stanniocalcin-1 inhibits growth and glycolysis in oral squamous cell carcinoma cells
  76. The expression and biological role of complement C1s in esophageal squamous cell carcinoma
  77. A novel GNAS mutation in pseudohypoparathyroidism type 1a with articular flexion deformity: A case report
  78. Predictive value of serum magnesium levels for prognosis in patients with non-small cell lung cancer undergoing EGFR-TKI therapy
  79. HSPB1 alleviates acute-on-chronic liver failure via the P53/Bax pathway
  80. IgG4-related disease complicated by PLA2R-associated membranous nephropathy: A case report
  81. Baculovirus-mediated endostatin and angiostatin activation of autophagy through the AMPK/AKT/mTOR pathway inhibits angiogenesis in hepatocellular carcinoma
  82. Metformin mitigates osteoarthritis progression by modulating the PI3K/AKT/mTOR signaling pathway and enhancing chondrocyte autophagy
  83. Evaluation of the activity of antimicrobial peptides against bacterial vaginosis
  84. Atypical presentation of γ/δ mycosis fungoides with an unusual phenotype and SOCS1 mutation
  85. Analysis of the microecological mechanism of diabetic kidney disease based on the theory of “gut–kidney axis”: A systematic review
  86. Omega-3 fatty acids prevent gestational diabetes mellitus via modulation of lipid metabolism
  87. Refractory hypertension complicated with Turner syndrome: A case report
  88. Interaction of ncRNAs and the PI3K/AKT/mTOR pathway: Implications for osteosarcoma
  89. Association of low attenuation area scores with pulmonary function and clinical prognosis in patients with chronic obstructive pulmonary disease
  90. Long non-coding RNAs in bone formation: Key regulators and therapeutic prospects
  91. The deubiquitinating enzyme USP35 regulates the stability of NRF2 protein
  92. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential diagnostic markers for rebleeding in patients with esophagogastric variceal bleeding
  93. G protein-coupled receptor 1 participating in the mechanism of mediating gestational diabetes mellitus by phosphorylating the AKT pathway
  94. LL37-mtDNA regulates viability, apoptosis, inflammation, and autophagy in lipopolysaccharide-treated RLE-6TN cells by targeting Hsp90aa1
  95. The analgesic effect of paeoniflorin: A focused review
  96. Chemical composition’s effect on Solanum nigrum Linn.’s antioxidant capacity and erythrocyte protection: Bioactive components and molecular docking analysis
  97. Knockdown of HCK promotes HREC cell viability and inner blood–retinal barrier integrity by regulating the AMPK signaling pathway
  98. The role of rapamycin in the PINK1/Parkin signaling pathway in mitophagy in podocytes
  99. Laryngeal non-Hodgkin lymphoma: Report of four cases and review of the literature
  100. Clinical value of macrogenome next-generation sequencing on infections
  101. Overview of dendritic cells and related pathways in autoimmune uveitis
  102. TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway
  103. Hypomethylation in promoters of PGC-1α involved in exercise-driven skeletal muscular alterations in old age
  104. Profile and antimicrobial susceptibility patterns of bacteria isolated from effluents of Kolladiba and Debark hospitals
  105. The expression and clinical significance of syncytin-1 in serum exosomes of hepatocellular carcinoma patients
  106. A histomorphometric study to evaluate the therapeutic effects of biosynthesized silver nanoparticles on the kidneys infected with Plasmodium chabaudi
  107. PGRMC1 and PAQR4 are promising molecular targets for a rare subtype of ovarian cancer
  108. Analysis of MDA, SOD, TAOC, MNCV, SNCV, and TSS scores in patients with diabetes peripheral neuropathy
  109. SLIT3 deficiency promotes non-small cell lung cancer progression by modulating UBE2C/WNT signaling
  110. The relationship between TMCO1 and CALR in the pathological characteristics of prostate cancer and its effect on the metastasis of prostate cancer cells
  111. Heterogeneous nuclear ribonucleoprotein K is a potential target for enhancing the chemosensitivity of nasopharyngeal carcinoma
  112. PHB2 alleviates retinal pigment epithelium cell fibrosis by suppressing the AGE–RAGE pathway
  113. Anti-γ-aminobutyric acid-B receptor autoimmune encephalitis with syncope as the initial symptom: Case report and literature review
  114. Comparative analysis of chloroplast genome of Lonicera japonica cv. Damaohua
  115. Human umbilical cord mesenchymal stem cells regulate glutathione metabolism depending on the ERK–Nrf2–HO-1 signal pathway to repair phosphoramide mustard-induced ovarian cancer cells
  116. Electroacupuncture on GB acupoints improves osteoporosis via the estradiol–PI3K–Akt signaling pathway
  117. Renalase protects against podocyte injury by inhibiting oxidative stress and apoptosis in diabetic nephropathy
  118. Review: Dicranostigma leptopodum: A peculiar plant of Papaveraceae
  119. Combination effect of flavonoids attenuates lung cancer cell proliferation by inhibiting the STAT3 and FAK signaling pathway
  120. Renal microangiopathy and immune complex glomerulonephritis induced by anti-tumour agents: A case report
  121. Correlation analysis of AVPR1a and AVPR2 with abnormal water and sodium and potassium metabolism in rats
  122. Gastrointestinal health anti-diarrheal mixture relieves spleen deficiency-induced diarrhea through regulating gut microbiota
  123. Myriad factors and pathways influencing tumor radiotherapy resistance
  124. Exploring the effects of culture conditions on Yapsin (YPS) gene expression in Nakaseomyces glabratus
  125. Screening of prognostic core genes based on cell–cell interaction in the peripheral blood of patients with sepsis
  126. Coagulation factor II thrombin receptor as a promising biomarker in breast cancer management
  127. Ileocecal mucinous carcinoma misdiagnosed as incarcerated hernia: A case report
  128. Methyltransferase like 13 promotes malignant behaviors of bladder cancer cells through targeting PI3K/ATK signaling pathway
  129. The debate between electricity and heat, efficacy and safety of irreversible electroporation and radiofrequency ablation in the treatment of liver cancer: A meta-analysis
  130. ZAG promotes colorectal cancer cell proliferation and epithelial–mesenchymal transition by promoting lipid synthesis
  131. Baicalein inhibits NLRP3 inflammasome activation and mitigates placental inflammation and oxidative stress in gestational diabetes mellitus
  132. Impact of SWCNT-conjugated senna leaf extract on breast cancer cells: A potential apoptotic therapeutic strategy
  133. MFAP5 inhibits the malignant progression of endometrial cancer cells in vitro
  134. Major ozonated autohemotherapy promoted functional recovery following spinal cord injury in adult rats via the inhibition of oxidative stress and inflammation
  135. Axodendritic targeting of TAU and MAP2 and microtubule polarization in iPSC-derived versus SH-SY5Y-derived human neurons
  136. Differential expression of phosphoinositide 3-kinase/protein kinase B and Toll-like receptor/nuclear factor kappa B signaling pathways in experimental obesity Wistar rat model
  137. The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review
  138. BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis
  139. Role of circRMRP and circRPL27 in chronic obstructive pulmonary disease
  140. Investigating the role of hyperexpressed HCN1 in inducing myocardial infarction through activation of the NF-κB signaling pathway
  141. Characterization of phenolic compounds and evaluation of anti-diabetic potential in Cannabis sativa L. seeds: In vivo, in vitro, and in silico studies
  142. Quantitative immunohistochemistry analysis of breast Ki67 based on artificial intelligence
  143. Ecology and Environmental Science
  144. Screening of different growth conditions of Bacillus subtilis isolated from membrane-less microbial fuel cell toward antimicrobial activity profiling
  145. Degradation of a mixture of 13 polycyclic aromatic hydrocarbons by commercial effective microorganisms
  146. Evaluation of the impact of two citrus plants on the variation of Panonychus citri (Acari: Tetranychidae) and beneficial phytoseiid mites
  147. Prediction of present and future distribution areas of Juniperus drupacea Labill and determination of ethnobotany properties in Antalya Province, Türkiye
  148. Population genetics of Todarodes pacificus (Cephalopoda: Ommastrephidae) in the northwest Pacific Ocean via GBS sequencing
  149. A comparative analysis of dendrometric, macromorphological, and micromorphological characteristics of Pistacia atlantica subsp. atlantica and Pistacia terebinthus in the middle Atlas region of Morocco
  150. Macrofungal sporocarp community in the lichen Scots pine forests
  151. Assessing the proximate compositions of indigenous forage species in Yemen’s pastoral rangelands
  152. Food Science
  153. Gut microbiota changes associated with low-carbohydrate diet intervention for obesity
  154. Reexamination of Aspergillus cristatus phylogeny in dark tea: Characteristics of the mitochondrial genome
  155. Differences in the flavonoid composition of the leaves, fruits, and branches of mulberry are distinguished based on a plant metabolomics approach
  156. Investigating the impact of wet rendering (solventless method) on PUFA-rich oil from catfish (Clarias magur) viscera
  157. Non-linear associations between cardiovascular metabolic indices and metabolic-associated fatty liver disease: A cross-sectional study in the US population (2017–2020)
  158. Knockdown of USP7 alleviates atherosclerosis in ApoE-deficient mice by regulating EZH2 expression
  159. Utility of dairy microbiome as a tool for authentication and traceability
  160. Agriculture
  161. Enhancing faba bean (Vicia faba L.) productivity through establishing the area-specific fertilizer rate recommendation in southwest Ethiopia
  162. Impact of novel herbicide based on synthetic auxins and ALS inhibitor on weed control
  163. Perspectives of pteridophytes microbiome for bioremediation in agricultural applications
  164. Fertilizer application parameters for drip-irrigated peanut based on the fertilizer effect function established from a “3414” field trial
  165. Improving the productivity and profitability of maize (Zea mays L.) using optimum blended inorganic fertilization
  166. Application of leaf multispectral analyzer in comparison to hyperspectral device to assess the diversity of spectral reflectance indices in wheat genotypes
  167. Animal Sciences
  168. Knockdown of ANP32E inhibits colorectal cancer cell growth and glycolysis by regulating the AKT/mTOR pathway
  169. Development of a detection chip for major pathogenic drug-resistant genes and drug targets in bovine respiratory system diseases
  170. Exploration of the genetic influence of MYOT and MB genes on the plumage coloration of Muscovy ducks
  171. Transcriptome analysis of adipose tissue in grazing cattle: Identifying key regulators of fat metabolism
  172. Comparison of nutritional value of the wild and cultivated spiny loaches at three growth stages
  173. Transcriptomic analysis of liver immune response in Chinese spiny frog (Quasipaa spinosa) infected with Proteus mirabilis
  174. Disruption of BCAA degradation is a critical characteristic of diabetic cardiomyopathy revealed by integrated transcriptome and metabolome analysis
  175. Plant Sciences
  176. Effect of long-term in-row branch covering on soil microorganisms in pear orchards
  177. Photosynthetic physiological characteristics, growth performance, and element concentrations reveal the calcicole–calcifuge behaviors of three Camellia species
  178. Transcriptome analysis reveals the mechanism of NaHCO3 promoting tobacco leaf maturation
  179. Bioinformatics, expression analysis, and functional verification of allene oxide synthase gene HvnAOS1 and HvnAOS2 in qingke
  180. Water, nitrogen, and phosphorus coupling improves gray jujube fruit quality and yield
  181. Improving grape fruit quality through soil conditioner: Insights from RNA-seq analysis of Cabernet Sauvignon roots
  182. Role of Embinin in the reabsorption of nucleus pulposus in lumbar disc herniation: Promotion of nucleus pulposus neovascularization and apoptosis of nucleus pulposus cells
  183. Revealing the effects of amino acid, organic acid, and phytohormones on the germination of tomato seeds under salinity stress
  184. Combined effects of nitrogen fertilizer and biochar on the growth, yield, and quality of pepper
  185. Comprehensive phytochemical and toxicological analysis of Chenopodium ambrosioides (L.) fractions
  186. Impact of “3414” fertilization on the yield and quality of greenhouse tomatoes
  187. Exploring the coupling mode of water and fertilizer for improving growth, fruit quality, and yield of the pear in the arid region
  188. Metagenomic analysis of endophytic bacteria in seed potato (Solanum tuberosum)
  189. Antibacterial, antifungal, and phytochemical properties of Salsola kali ethanolic extract
  190. Exploring the hepatoprotective properties of citronellol: In vitro and in silico studies on ethanol-induced damage in HepG2 cells
  191. Enhanced osmotic dehydration of watermelon rind using honey–sucrose solutions: A study on pre-treatment efficacy and mass transfer kinetics
  192. Effects of exogenous 2,4-epibrassinolide on photosynthetic traits of 53 cowpea varieties under NaCl stress
  193. Comparative transcriptome analysis of maize (Zea mays L.) seedlings in response to copper stress
  194. An optimization method for measuring the stomata in cassava (Manihot esculenta Crantz) under multiple abiotic stresses
  195. Fosinopril inhibits Ang II-induced VSMC proliferation, phenotype transformation, migration, and oxidative stress through the TGF-β1/Smad signaling pathway
  196. Antioxidant and antimicrobial activities of Salsola imbricata methanolic extract and its phytochemical characterization
  197. Bioengineering and Biotechnology
  198. Absorbable calcium and phosphorus bioactive membranes promote bone marrow mesenchymal stem cells osteogenic differentiation for bone regeneration
  199. New advances in protein engineering for industrial applications: Key takeaways
  200. An overview of the production and use of Bacillus thuringiensis toxin
  201. Research progress of nanoparticles in diagnosis and treatment of hepatocellular carcinoma
  202. Bioelectrochemical biosensors for water quality assessment and wastewater monitoring
  203. PEI/MMNs@LNA-542 nanoparticles alleviate ICU-acquired weakness through targeted autophagy inhibition and mitochondrial protection
  204. Unleashing of cytotoxic effects of thymoquinone-bovine serum albumin nanoparticles on A549 lung cancer cells
  205. Erratum
  206. Erratum to “Investigating the association between dietary patterns and glycemic control among children and adolescents with T1DM”
  207. Erratum to “Activation of hypermethylated P2RY1 mitigates gastric cancer by promoting apoptosis and inhibiting proliferation”
  208. Retraction
  209. Retraction to “MiR-223-3p regulates cell viability, migration, invasion, and apoptosis of non-small cell lung cancer cells by targeting RHOB”
  210. Retraction to “A data mining technique for detecting malignant mesothelioma cancer using multiple regression analysis”
  211. Special Issue on Advances in Neurodegenerative Disease Research and Treatment
  212. Transplantation of human neural stem cell prevents symptomatic motor behavior disability in a rat model of Parkinson’s disease
  213. Special Issue on Multi-omics
  214. Inflammasome complex genes with clinical relevance suggest potential as therapeutic targets for anti-tumor drugs in clear cell renal cell carcinoma
  215. Gastroesophageal varices in primary biliary cholangitis with anti-centromere antibody positivity: Early onset?
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Heruntergeladen am 22.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/biol-2022-0862/html
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