Abstract
Background
Family caregiving for dementia patients is a challenging task, with profound effects on caregivers’ physical and mental well-being. The purpose of this study was to explore the impact of Kolb’s experiential learning theory on the caregiving burden and psychological status of caregivers for dementia patients.
Methods
This study enrolled 110 caregivers of nursing dementia patients. These caregivers were divided into two groups: a control group (n = 55) and an intervention group (n = 55). The control group received routine care, while the intervention group received nursing based on Kolb’s experiential learning theory in addition to routine care. Changes in caregiving burden and psychological status were compared between the two groups before and after the intervention.
Result
The results showed that after the intervention, the intervention group’s caregivers had significantly lower scores on the caregiver burden inventory dimensions and total score compared to the control group (P < 0.05). Additionally, the intervention group’s self-assessment scores on the self-rating anxiety scale and self-rating depression scale were also lower than those of the control group (P < 0.05).
Conclusion
Kolb’s experiential learning theory has a positive impact on alleviating the caregiving burden and reducing anxiety and depression among family caregivers of dementia patients.
1 Introduction
“Caregiver burden” refers to the physical, psychological, social, and economic challenges faced by family members while caring for elderly individuals with disabilities [1]. As the health condition of dementia patients gradually deteriorates, their demands and dependence on caregivers increase, resulting in a heavier burden for the caregivers [2]. Over time, caregivers continually confront the worsening condition of their loved ones, which significantly impacts their psychological well-being [3]. In our country, dementia patient care is primarily carried out by family caregivers, but the current state of caregivers’ physical and mental health and caregiving skills is not optimistic [4]. Research indicates that nearly half of caregivers lack essential caregiving knowledge, leading to delays in early diagnosis and intervention for dementia patients [5].
In 1984, the renowned American educator Kolb introduced the Experiential Learning Theory [6], which posits that learning occurs when individuals acquire and transform experiences. According to Kolb, knowledge formation results from “grasping” and “transforming,” enabling better understanding and application of knowledge. While Kolb’s theory has been applied to various patient populations in medical and nursing fields, there is a lack of research on its application to dementia patients’ family caregivers. Therefore, this study aims to explore the impact of a nursing learning plan based on Kolb’s theory on caregiver burden and psychological congruence among family caregivers of dementia patients.
2 Methods
2.1 Study participants
For this research, we enrolled 110 caregivers diagnosed with dementia in the Department of Psychiatry, Huzhou Third Municipal Hospital, the Affiliated Hospital of Huzhou University, from April 2022 to August 2023. The work was carried out in accordance with the Declaration of Helsinki with the research approved by the Ethics Committee of Huzhou Third Municipal Hospital, the Affiliated Hospital of Huzhou University, under approval No. 2022-064. All participants provide a written informed consent in compliance with the ethics regulations. The participants were divided into control and intervention groups using a random number table method (n = 55, respectively). Inclusion criteria for patients were as follows: (1) clinical diagnosis of dementia with some communication ability and (2) age ≥60 years. Exclusion criteria were: (1) patients with critical conditions requiring intensive care unit (ICU) treatment during the intervention period or with fatal outcomes and (2) patients with severe psychiatric symptoms unable to follow instructions.
2.2 Inclusion criteria for caregivers
Caregivers must be 18 years of age or older. Caregivers should be primary caregivers (if the patient has multiple caregivers, the order of preference is spouse, parents or children, and others). The duration of caregiving must be at least 3 months, with an expected continuation of care for at least 6 months. Caregivers should have at least an elementary school education level. Participation in the study is voluntary and requires informed consent.
2.3 Exclusion criteria for caregivers
Caregivers with congenital or acquired hearing impairments or communication difficulties due to accidents or other reasons should be excluded. Caregivers with psychiatric disorders or cognitive impairments and caregivers currently participating in other research projects should be excluded either. In addition, caregivers whose dementia patients are critically ill and require ICU treatment or have a fatal outcome during the intervention period and who are unable to complete intervention activities due to personal reasons should be excluded.
2.4 Intervention study
Both the control group and the intervention group underwent a 4-week intervention.
For the control group, routine nursing care was provided to family caregivers. Disease-related knowledge was imparted primarily through one-on-one education, supplemented by relevant health education manuals. The content covered various aspects of dementia patient care, including basic care, safety measures, medication management, emotional support, and cognitive function care.
For the intervention group, a nursing learning plan based on Kolb’s theory was added to the control group’s routine. Specific measures included:
Preparation: Before the intervention, data on general patient information, caregiver burden, and psychological status were collected to create personalized learning plans.
Personnel training: Standardized training was provided to group members, covering Kolb’s theory, intervention measures, and relevant precautions. Roles within the group were clearly defined.
Implementation of nursing plan based on Kolb’s theory: Kolb’s experiential learning theory is a cyclical process that includes four stages (Figure 1): concrete experience, reflective observation, abstract conceptualization, and active experimentation. Learners first start the learning process through concrete experiences, then reflect and observe these experiences, abstract concepts, and theories from them, and finally, apply these concepts to new contexts through active experimentation, thus starting a new cycle.
In detail, this method is conducted twice a week for 60 min each time. The nursing researcher played the role of a facilitator in the Kolb theory learning plan, introducing the day’s schedule and important notices to family caregivers. Stage 1 (concrete experience): caregivers were asked to play three roles based on case studies: dementia patient, dementia caregiver, and observer. After role-playing, caregivers interacted freely with simulated dementia patients. The nursing researcher created a friendly atmosphere to facilitate easy conversation. Stage 2 (reflective observation): after the role-playing activity, caregivers gathered in a meeting room to reflect on their performance and discuss challenges encountered in daily patient care. They focused on what dementia patients had said to enhance empathy. The nursing researcher encouraged caregivers to express themselves bravely. Stage 3 (abstract conceptualization): Through discussions with the nursing researcher, caregivers gained a broader and deeper understanding of their experiences. They applied the learned nursing knowledge to daily care activities for dementia patients. For instance, if a caregiver reported that a dementia patient repeatedly shared the same story, the nursing researcher provided positive feedback on how to patiently listen to the patient’s repetitive sharing. Additionally, caregivers were advised to introduce new topics to expand conversations and elicit new stories from dementia patients. The nursing researcher acted as an educational guide, providing guidance and suggestions. Stage 4 (active experimentation): Caregivers applied the knowledge acquired in the first three stages to actual dementia patient care scenarios. The nursing researcher helped caregivers face and cope with new challenges.
Timely summaries and feedback: Research team members actively participated in and documented the implementation according to the intervention plan. After each intervention, summaries and feedback were provided, and problems were promptly analyzed and resolved.

The model graphic of Kolb’s experiential learning.
2.5 Observation indicators
Caregiver burden: Assessed using the caregiver burden inventory (CBI) [7]. This inventory comprises 24 items, covering multiple dimensions of burden faced by family members during the care of elderly individuals with disabilities. The dimensions include physical burden, emotional burden, social burden, time dependency burden, and developmental restriction burden. Each item is rated on a 5-point scale (0–4), resulting in a total score ranging from 0 to 96. Higher scores indicate a heavier burden borne during the caregiving process.
Psychological state: Evaluated using the self-rating anxiety scale (SAS) and the self-rating depression scale (SDS). These scales were developed by Zung in the 1970s [8,9], consisting of 20 items and a Likert 4-point rating system. Practically, higher scores indicate more severe anxiety and depression symptoms in patients.
2.6 Statistical analysis
We used SPSS 21.0 statistical software for data analysis. Descriptive statistics were employed to present data in the form of mean ± standard deviation, frequencies, and proportions. For the baseline categorical data, we used the chi-square test (χ²). For comparison of caregiver burden and psychological states between the two groups, a paired sample t-test was applied to investigate the different intervention outcomes. A significance level of P < 0.05 was considered statistically significant.
3 Results
3.1 The baseline characteristics of the studied caregivers
To perform an objective judgment on the impact of Kolb’s Experiential Learning Theory, we should first exclude the influence of participants’ baseline characteristics prior to downstream analysis. As shown in Table 1, there was no statistically significant difference in the general characteristics between the two groups (P > 0.05), including factors such as gender, age, disease duration, nursing duration, and education level.
The baseline characteristics of the study participants
| Item | Control group (n = 55) | Intervention group (n = 55) | χ 2/t Value | P-value | |
|---|---|---|---|---|---|
| Patients | |||||
| Gender (n) | Male | 27 | 28 | 0.036 | 0.849 |
| Female | 28 | 27 | |||
| Average age (years) | 70.22 ± 6.37 | 70.11 ± 6.15 | 0.092 | 0.927 | |
| Disease duration (years) | 4.01 ± 1.23 | 3.88 ± 0.97 | 0.615 | 0.540 | |
| Disease severity (n) | Mid-stage | 40 | 43 | 0.442 | 0.506 |
| Late stage | 15 | 12 | |||
| Caregivers | |||||
| Gender (n) | Male | 22 | 25 | 0.334 | 0.563 |
| Female | 33 | 30 | |||
| Average age (years) | 58.13 ± 7.62 | 58.21 ± 7.73 | 0.066 | 0.948 | |
| Education level (n) | Junior high school or below | 25 | 28 | 0.328 | 0.567 |
| Technical secondary school or above | 30 | 27 | |||
| Relationship with patient (n) | Spouse | 24 | 26 | 1.171 | 0.557 |
| Children | 21 | 23 | |||
| Other | 10 | 6 | |||
| Caregiving duration (years) | 3.42 ± 1.11 | 3.51 ± 1.05 | 0.437 | 0.663 |
In addition, a comparison of basic burden levels was also made between caregivers and ordinary people (Table 2), which shows that the caregivers were under higher pressure than ordinary people were.
The comparison of basic burden levels between caregivers and ordinary people
| Groups | Cases | SAS | SDS |
|---|---|---|---|
| Caregivers group | n = 110 | 48.99 ± 5.13* | 46.78 ± 5.30* |
| Ordinary people group | n = 110 | 28.66 ± 5.89* | 32.19 ± 4.61* |
Note: *P < 0.05.
3.2 The intervention group shows reduced caregiver burden
Before the intervention, there was no statistically significant difference in the CBI scores between the two groups (P > 0.05). After the intervention, the intervention group’s caregivers had lower CBI scores (P < 0.05) across various dimensions, including Physical Burden, Emotional Burden, Social Burden, Time Dependency Burden, and Developmental Restriction Burden. In addition, the total score of the intervention group, compared to the control group displays lower CBI scores with statistically significant differences (P < 0.05) (Table 3).
Comparison of caregiver burden between the two groups
| Group | Time | Physical burden | Emotional burden | Social burden | Time dependency burden | Developmental restriction burden | Total score |
|---|---|---|---|---|---|---|---|
| Control group (n = 55) | Before intervention | 6.36 ± 1.12 | 7.89 ± 1.43 | 5.46 ± 0.94 | 12.85 ± 1.57 | 11.48 ± 1.53 | 48.77 ± 5.76 |
| After intervention | 5.85 ± 0.98* | 6.73 ± 1.38* | 4.77 ± 0.82* | 11.73 ± 1.48* | 10.35 ± 1.42* | 39.73 ± 5.32* | |
| Intervention group (n = 55) | Before intervention | 6.41 ± 1.10 | 7.84 ± 1.47 | 5.39 ± 0.92 | 12.83 ± 1.52 | 11.49 ± 1.57 | 48.34 ± 5.85 |
| After intervention | 5.01 ± 0.86*,# | 5.65 ± 1.31*,# | 4.01 ± 0.70*,# | 10.33 ± 1.36*,# | 9.23 ± 1.24*,# | 37.81 ± 3.92*,# |
Note: In comparison to “Before Intervention Group,” *P < 0.05: In comparison to “Control Group” and # P < 0.05.
3.3 The psychological state of the intervention group is ameliorated
To investigate the psychological state of the participants in a quantitative manner, SAS and SDS scores were recorded for the analysis. As is illustrated in Table 4, before the intervention, there was no statistically significant difference in the SAS and SDS scores between the two groups (P > 0.05). Whereas after the intervention, SAS and SDS scores of the intervention group were significantly reduced than those of the control group (P < 0.05).
Comparison of psychological states between the two groups
| Group | SAS | SDS | ||
|---|---|---|---|---|
| Before intervention | After intervention | Before intervention | After intervention | |
| Control group | 58.81 ± 7.29 | 48.99 ± 5.13* | 56.52 ± 5.89 | 46.78 ± 5.30a |
| Intervention group | 60.10 ± 7.47 | 42.76 ± 4.82* | 58.03 ± 6.00 | 40.26 ± 4.81a |
| t-value | 0.897 | 6.432 | 1.299 | 6.498 |
| P-value | 0.353 | <0.001 | 0.203 | <0.001 |
Note: * indicates statistical significance (P < 0.05) within the group before and after intervention.
4 Discussion
Alzheimer’s disease, commonly referred to as “senile dementia,” is the most prevalent type of dementia, accounting for approximately two-thirds of all cases. It encompasses various subtypes, including vascular dementia, temporal lobe dementia, and several rare forms of dementia [10]. Globally, around 47 million people suffer from dementia, with age being the primary risk factor for its development. Caring for family members affected by dementia poses a long-term and challenging task [11]. In the middle and later stages of dementia, patients experience cognitive impairments and memory decline, often accompanied by emotional instability, which can lead to conflicts with caregivers. Among this group of family caregivers for dementia patients, a sense of coherence has been shown to predict health-related quality of life, caregiving burden, and caregiving capacity [12].
The nursing learning plan based on Kolb’s theory is an educational approach rooted in experiential learning, which can be traced back to the Experiential Learning Theory proposed by American psychologist David Kolb in the 1970s [13]. According to Kolb, individuals acquire knowledge and skills through a process that involves practical experience, observation, and reflection, which they then apply in real-world contexts [14]. The nursing learning plan, grounded in Kolb’s theory, has been validated in various nursing practice domains and has been shown to positively impact nursing professionals’ competence and care quality [15]. This approach emphasizes active learner participation and experiential engagement [16]. Learners immerse themselves in nursing scenarios through practice and role-playing, leading to a deeper understanding and practical application of nursing knowledge. Additionally, reflection and discussion play a crucial role. By reflecting on observations and abstract concepts, learners enhance their understanding of experiential learning and expand their knowledge through sharing and dialogue. Furthermore, the nursing learning plan based on Kolb’s theory underscores the importance of practice and application. Learners actively apply acquired knowledge to real-world situations, thereby enhancing their nursing skills and confidence [17].
The research results indicate that the intervention group had lower scores in various dimensions of caregiver burden, including physical burden, emotional burden, social burden, time dependency burden, and developmental restriction burden, compared to the control group (P < 0.05). This suggests that the nursing learning plan based on Kolb’s theory can assist caregivers in better coping with the various burdens associated with caregiving, which aligns with the findings of the other study [18]. Additionally, caregivers in the intervention group experienced significant relief from negative emotions. Previous research has also demonstrated that Kolb’s theory can provide effective and systematic learning plans and strategies for patients and their caregivers, leading to professional guidance from healthcare providers [19]. This not only expands social resources for caregivers but also helps alleviate anxiety and negative emotions, consistent with the results of this study. Besides, it was observed in the study that there was no significant difference in nursing skills before intervention, but after applying Kolb’s experiential learning theory, the nursing skills of the intervention group were improved. Therefore, implementing a nursing learning plan based on Kolb’s theory enables caregivers to better understand and adapt to the needs of dementia patients, fostering stronger emotional connections and reducing negative emotions, ultimately alleviating stress and burden during the caregiving process.
The effectiveness of nursing learning plans based on Kolb’s theory primarily might stem from two reasons. Firstly, it enhanced the understanding and application of nursing knowledge. Through role-playing, caregivers gain firsthand experience of dementia patients’ feelings and challenges, thereby enhancing empathy toward dementia patients. The reflection and abstract conceptualization stages help caregivers gain a deeper understanding of their experiences and apply the acquired knowledge to practical nursing care. Second, the application of knowledge in real contexts was improved. The active experimentation stage assists caregivers in applying learned knowledge to actual situations, thereby boosting nursing skills and confidence.
However, implementing nursing learning plans based on Kolb’s theory faces certain challenges. On the one hand, the implementation of the learning plan requires sufficient resources and support, including support for training instructors, educational materials, and scheduling. On the other hand, caregivers’ engagement and motivation are also necessitated. Caregivers may encounter limitations in terms of time, energy, and resistance to new learning methods. Encouragement and appropriate support are crucial to foster active participation and motivation among caregivers. As for the weakness of this study, lacking investigation of the caregivers from different cultural backgrounds may lead to a one-sided conclusion. Also, adopting merely Kolb’s theory may not be the optimal strategy. For future research, we recommend further exploring the applicability and effectiveness of nursing learning plans based on Kolb’s theory across different cultural and social contexts. Additionally, combining Kolb’s theory with other educational methods and strategies could benefit clinical outcomes.
In sum, nursing learning plans based on Kolb’s theory have a positive impact on alleviating caregiver burden and improving the psychological well-being of family caregivers of dementia patients. By reducing the burden of care and enhancing understanding of dementia patients, as well as fostering stronger emotional connections, this plan is worthy of clinical implementation and promotion.
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Funding information: This work was supported by the Research Project of Huzhou Third Municipal Hospital under Grant no. 2022SY2022082.
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Author contributions: Conceptualization: H. Ding. Methodology: Y. Xu. H. Ding. Investigation: Y. Xu, J. Lu, and X. Yu. Data curation: Y. Xu and X. Yu. Writing: Y. Xu and H. Ding. Supervision: H. Ding.
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Conflict of interest: No direct or indirect commercial incentive associated with the publishing of this article.
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Data availability statement: All data included in this study are available upon request.
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- The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
- Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
- Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
- Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
- Analysis of serum metabolomics in patients with different types of chronic heart failure
- Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
- Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
- Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
- METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
- The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
- Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
- Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
- Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
- Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
- Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
- Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
- Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
- Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
- Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
- Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
- Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
- HALP score in Demodex blepharitis: A case–control study
- Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
- Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
- Comparison of the two intestinal anastomosis methods in pediatric patients
- Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
- Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
- Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
- Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
- Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
- Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
- Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
- Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
- A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
- Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
- FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
- Association of placenta weight and morphology with term low birth weight: A case–control study
- Investigation of the pathogenic variants induced Sjogren’s syndrome in Turkish population
- Nucleotide metabolic abnormalities in post-COVID-19 condition and type 2 diabetes mellitus patients and their association with endocrine dysfunction
- TGF-β–Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization
- Ultrasound-guided unilateral versus bilateral erector spinae plane block for postoperative analgesia of patients undergoing laparoscopic cholecystectomy
- Profiling gut microbiome dynamics in subacute thyroiditis: Implications for pathogenesis, diagnosis, and treatment
- Delta neutrophil index, CRP/albumin ratio, procalcitonin, immature granulocytes, and HALP score in acute appendicitis: Best performing biomarker?
- Anticancer activity mechanism of novelly synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative on colon cancer cells
- H2valdien3 arrests the cell cycle and induces apoptosis of gastric cancer
- Prognostic relevance of PRSS2 and its immune correlates in papillary thyroid carcinoma
- Association of SGLT2 inhibition with psychiatric disorders: A Mendelian randomization study
- Motivational interviewing for alcohol use reduction in Thai patients
- Luteolin alleviates oxygen-glucose deprivation/reoxygenation-induced neuron injury by regulating NLRP3/IL-1β signaling
- Polyphyllin II inhibits thyroid cancer cell growth by simultaneously inhibiting glycolysis and oxidative phosphorylation
- Relationship between the expression of copper death promoting factor SLC31A1 in papillary thyroid carcinoma and clinicopathological indicators and prognosis
- CSF2 polarized neutrophils and invaded renal cancer cells in vitro influence
- Proton pump inhibitors-induced thrombocytopenia: A systematic literature analysis of case reports
- The current status and influence factors of research ability among community nurses: A sequential qualitative–quantitative study
- OKAIN: A comprehensive oncology knowledge base for the interpretation of clinically actionable alterations
- The relationship between serum CA50, CA242, and SAA levels and clinical pathological characteristics and prognosis in patients with pancreatic cancer
- Identification and external validation of a prognostic signature based on hypoxia–glycolysis-related genes for kidney renal clear cell carcinoma
- Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility
- Relationship of resting echocardiography combined with serum micronutrients to the severity of low-gradient severe aortic stenosis
- Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial
- The diagnostic performance of machine learning-based FFRCT for coronary artery disease: A meta-analysis
- Comparing biofeedback device vs diaphragmatic breathing for bloating relief: A randomized controlled trial
- Serum uric acid to albumin ratio and C-reactive protein as predictive biomarkers for chronic total occlusion and coronary collateral circulation quality
- Multiple organ scoring systems for predicting in-hospital mortality of sepsis patients in the intensive care unit
- Single-cell RNA sequencing data analysis of the inner ear in gentamicin-treated mice via intraperitoneal injection
- Suppression of cathepsin B attenuates myocardial injury via limiting cardiomyocyte apoptosis
- Influence of sevoflurane combined with propofol anesthesia on the anesthesia effect and adverse reactions in children with acute appendicitis
- Review Articles
- The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
- Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
- Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
- Review of mechanisms and frontier applications in IL-17A-induced hypertension
- Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
- The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
- The application of augmented reality in robotic general surgery: A mini-review
- The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
- Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
- Plant polyphenols, terpenes, and terpenoids in oral health
- Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
- End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
- The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
- Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
- PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
- Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
- Giant borderline ovarian tumours – review of the literature
- Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
- Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
- Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
- Supplement strategies for infertility in overweight women: Evidence and legal insights
- Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
- A meta-analysis of the effects of DBS on cognitive function in patients with advanced PD
- Protective role of selenium in sepsis: Mechanisms and potential therapeutic strategies
- Strategies for hyperkalemia management in dialysis patients: A systematic review
- C-reactive protein-to-albumin ratio in peripheral artery disease
- Case Reports
- Delayed graft function after renal transplantation
- Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
- Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
- Giant right atrial hemangioma presenting with ascites: A case report
- Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
- EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
- Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report
- Coronary artery anomalies: A case of the “malignant” left coronary artery and its surgical management
- Rapid Communication
- Biological properties of valve materials using RGD and EC
-
A single oral administration of flavanols enhances short
-term memory in mice along with increased brain-derived neurotrophic factor - Letter to the Editor
- Role of enhanced external counterpulsation in long COVID
- Expression of Concern
- Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
- Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
- Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
- Corrigendum
- Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
- Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
- Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
- Retraction
- Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
- Retraction of: “LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through downregulating SP-A by sponging to miR-424”
- Retraction of: “SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways”
- Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
- Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
- Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
- The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
- Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
- Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
- Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
- Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
- Special Issue The evolving saga of RNAs from bench to bedside - Part III
- Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
- The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
- Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
- Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
- A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
- Red cell distribution width predicts early kidney injury: A NHANES cross-sectional study
- Special Issue Diabetes mellitus: pathophysiology, complications & treatment
- Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
- Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
- A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
- A review of brain research on T2DM-related cognitive dysfunction
- Metformin and estrogen modulation in LABC with T2DM: A 36-month randomized trial
- Special Issue Innovative Biomarker Discovery and Precision Medicine in Cancer Diagnostics
- CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
Articles in the same Issue
- Research Articles
- Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
- Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
- Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
- Risk factors for severe adverse drug reactions in hospitalized patients
- Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
- Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
- CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
- Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
- Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
- Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
- Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
- Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
- Association between statin administration and outcome in patients with sepsis: A retrospective study
- Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
- A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
- Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
- Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
- Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
- Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
- Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
- The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
- Health literacy and health-related quality of life: The mediating role of irrational happiness
- Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
- Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
- Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
- Clinical analysis of ten cases of HIV infection combined with acute leukemia
- Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
- Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
- Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
- Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
- Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
- The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
- The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
- Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
- Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
- Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
- The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
- Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
- A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
- A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
- Identifying early screening factors for depression in middle-aged and older adults: A cohort study
- Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
- Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
- High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
- RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
- Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
- Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
- The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
- Expression and clinical significance of ITGA3 in breast cancer
- Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
- rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
- Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
- Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
- Gender beliefs and legitimization of dating violence in adolescents
- Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
- Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
- Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
- Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
- Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
- Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
- GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
- Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
- MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
- Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
- Trends in research on preterm birth in twin pregnancy based on bibliometrics
- Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
- Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
- Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
- Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
- Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
- CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
- Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
- Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
- Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
- Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
- Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
- Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
- Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
- The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
- The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
- Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
- Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
- The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
- Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
- Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
- Correlation of serum calprotectin with outcome of acute cerebral infarction
- Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
- Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
- The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
- Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
- Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
- Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
- Analysis of serum metabolomics in patients with different types of chronic heart failure
- Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
- Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
- Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
- METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
- The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
- Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
- Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
- Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
- Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
- Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
- Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
- Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
- Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
- Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
- Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
- Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
- HALP score in Demodex blepharitis: A case–control study
- Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
- Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
- Comparison of the two intestinal anastomosis methods in pediatric patients
- Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
- Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
- Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
- Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
- Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
- Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
- Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
- Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
- A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
- Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
- FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
- Association of placenta weight and morphology with term low birth weight: A case–control study
- Investigation of the pathogenic variants induced Sjogren’s syndrome in Turkish population
- Nucleotide metabolic abnormalities in post-COVID-19 condition and type 2 diabetes mellitus patients and their association with endocrine dysfunction
- TGF-β–Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization
- Ultrasound-guided unilateral versus bilateral erector spinae plane block for postoperative analgesia of patients undergoing laparoscopic cholecystectomy
- Profiling gut microbiome dynamics in subacute thyroiditis: Implications for pathogenesis, diagnosis, and treatment
- Delta neutrophil index, CRP/albumin ratio, procalcitonin, immature granulocytes, and HALP score in acute appendicitis: Best performing biomarker?
- Anticancer activity mechanism of novelly synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative on colon cancer cells
- H2valdien3 arrests the cell cycle and induces apoptosis of gastric cancer
- Prognostic relevance of PRSS2 and its immune correlates in papillary thyroid carcinoma
- Association of SGLT2 inhibition with psychiatric disorders: A Mendelian randomization study
- Motivational interviewing for alcohol use reduction in Thai patients
- Luteolin alleviates oxygen-glucose deprivation/reoxygenation-induced neuron injury by regulating NLRP3/IL-1β signaling
- Polyphyllin II inhibits thyroid cancer cell growth by simultaneously inhibiting glycolysis and oxidative phosphorylation
- Relationship between the expression of copper death promoting factor SLC31A1 in papillary thyroid carcinoma and clinicopathological indicators and prognosis
- CSF2 polarized neutrophils and invaded renal cancer cells in vitro influence
- Proton pump inhibitors-induced thrombocytopenia: A systematic literature analysis of case reports
- The current status and influence factors of research ability among community nurses: A sequential qualitative–quantitative study
- OKAIN: A comprehensive oncology knowledge base for the interpretation of clinically actionable alterations
- The relationship between serum CA50, CA242, and SAA levels and clinical pathological characteristics and prognosis in patients with pancreatic cancer
- Identification and external validation of a prognostic signature based on hypoxia–glycolysis-related genes for kidney renal clear cell carcinoma
- Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility
- Relationship of resting echocardiography combined with serum micronutrients to the severity of low-gradient severe aortic stenosis
- Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial
- The diagnostic performance of machine learning-based FFRCT for coronary artery disease: A meta-analysis
- Comparing biofeedback device vs diaphragmatic breathing for bloating relief: A randomized controlled trial
- Serum uric acid to albumin ratio and C-reactive protein as predictive biomarkers for chronic total occlusion and coronary collateral circulation quality
- Multiple organ scoring systems for predicting in-hospital mortality of sepsis patients in the intensive care unit
- Single-cell RNA sequencing data analysis of the inner ear in gentamicin-treated mice via intraperitoneal injection
- Suppression of cathepsin B attenuates myocardial injury via limiting cardiomyocyte apoptosis
- Influence of sevoflurane combined with propofol anesthesia on the anesthesia effect and adverse reactions in children with acute appendicitis
- Review Articles
- The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
- Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
- Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
- Review of mechanisms and frontier applications in IL-17A-induced hypertension
- Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
- The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
- The application of augmented reality in robotic general surgery: A mini-review
- The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
- Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
- Plant polyphenols, terpenes, and terpenoids in oral health
- Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
- End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
- The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
- Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
- PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
- Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
- Giant borderline ovarian tumours – review of the literature
- Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
- Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
- Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
- Supplement strategies for infertility in overweight women: Evidence and legal insights
- Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
- A meta-analysis of the effects of DBS on cognitive function in patients with advanced PD
- Protective role of selenium in sepsis: Mechanisms and potential therapeutic strategies
- Strategies for hyperkalemia management in dialysis patients: A systematic review
- C-reactive protein-to-albumin ratio in peripheral artery disease
- Case Reports
- Delayed graft function after renal transplantation
- Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
- Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
- Giant right atrial hemangioma presenting with ascites: A case report
- Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
- EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
- Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report
- Coronary artery anomalies: A case of the “malignant” left coronary artery and its surgical management
- Rapid Communication
- Biological properties of valve materials using RGD and EC
-
A single oral administration of flavanols enhances short
-term memory in mice along with increased brain-derived neurotrophic factor - Letter to the Editor
- Role of enhanced external counterpulsation in long COVID
- Expression of Concern
- Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
- Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
- Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
- Corrigendum
- Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
- Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
- Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
- Retraction
- Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
- Retraction of: “LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through downregulating SP-A by sponging to miR-424”
- Retraction of: “SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways”
- Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
- Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
- Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
- The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
- Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
- Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
- Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
- Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
- Special Issue The evolving saga of RNAs from bench to bedside - Part III
- Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
- The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
- Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
- Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
- A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
- Red cell distribution width predicts early kidney injury: A NHANES cross-sectional study
- Special Issue Diabetes mellitus: pathophysiology, complications & treatment
- Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
- Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
- A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
- A review of brain research on T2DM-related cognitive dysfunction
- Metformin and estrogen modulation in LABC with T2DM: A 36-month randomized trial
- Special Issue Innovative Biomarker Discovery and Precision Medicine in Cancer Diagnostics
- CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms