Startseite Medizin Influence of sevoflurane combined with propofol anesthesia on the anesthesia effect and adverse reactions in children with acute appendicitis
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Influence of sevoflurane combined with propofol anesthesia on the anesthesia effect and adverse reactions in children with acute appendicitis

  • Peng Zhang , Jun Zhang und Feng Chen EMAIL logo
Veröffentlicht/Copyright: 6. Dezember 2025
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Open Medicine
Aus der Zeitschrift Open Medicine Band 20 Heft 1

Abstract

Objective

This study aimed to investigate the effect of sevoflurane combined with propofol anesthesia on the anesthesia effect and adverse reactions in children undergoing acute appendicitis surgery.

Methods

A total of 104 children with acute appendicitis who underwent surgery were included and assigned into the observation group (sevoflurane combined with propofol anesthesia, 55 cases) and the control group (propofol anesthesia, 49 cases). The two groups were compared in terms of anesthesia effects, recovery quality, and the occurrence of adverse reactions, while observing changes in patients’ hemodynamics and stress levels during anesthesia.

Results

Riker sedation and agitation scores were reduced in the observation group compared to the control group. The time to disappearance of pain and eyelash reflexes and the induction time of anesthesia were shortened, and heart rate and mean arterial pressure improved in the observation group. Cortisol, norepinephrine, and adrenocorticotropic hormone decreased in the observation group (P < 0.05). The occurrence of adverse reactions was not significantly different between the two groups (P > 0.05).

Conclusion

The combination of sevoflurane and propofol anesthesia in children with acute appendicitis can enhance the anesthesia effect and recovery quality and stabilize the body’s hemodynamics and stress state.

Keywords: sevoflurane; propofol; combined anesthesia; acute appendicitis in children; surgical treatment; anesthesia effect; adverse reactions

1 Introduction

Appendicitis in children is a pediatric acute abdomen condition, marked by a hidden onset, a high chance of perforation, and a propensity to develop into diffuse peritonitis. Clinically, bacterial infection, appendix cavity obstruction, blood flow disorder, and neurological factors are believed to be main contributing factors [1]. At present, surgery is often applied to treat acute appendicitis in children. Anesthesia is the primary method of surgical analgesia and protects the respiratory and circulatory systems [2,3]. However, considering the young age of pediatrics, anesthesia sensitivity issues, and the many uncertainties in the anesthesia process [4], the development of a targeted anesthesia plan based on the characteristics of pediatrics is the key to facilitating a smooth surgical procedure.

Propofol, an intravenous anesthetic with an ultra-short duration of action, is advantageous due to its short half-life, lack of significant metabolic concerns post-infusion, and quick recovery following discontinuation. However, its analgesic effect is not good [5]. Sevoflurane is a widely used inhalation anesthetic in medical settings, known for its quick induction, simple anesthesia adjustment, stable anesthesia process, and minimal respiratory tract irritation [6,7]. Compound anesthesia has attracted much attention in clinical procedures in recent decades. It not only takes advantage of the synergistic effect between drugs, but also relatively reduces the amount of anesthetics used, thus reducing the risk of dose-related adverse effects and ensuring a more stable and anesthetic effect. A typical example of balanced anesthesia is the use of both intravenous and inhalation methods [8]. It maximizes the benefits of both inhalation and intravenous anesthesia, effectively managing surgery-induced cardiovascular reflexes without significant circulatory suppression, and better supports anesthesia maintenance [9]. Sevoflurane inhalation combined with intravenous isoproterenol anesthesia can achieve better anesthetic effects [10]. However, the effect of combined anesthesia with propofol on children is still inconclusive.

Therefore, the purpose of this study was to figure out the effect of sevoflurane combined with propofol on the anesthesia effect and adverse reactions in children with acute appendicitis surgery, and to offer a reference for the selection of anesthesia methods for children.

2 Materials and methods

2.1 Clinical data

From February 2019 to August 2021, a total of 104 children with acute appendicitis who underwent surgical treatment were included and assigned into the observation group (sevoflurane combined with propofol anesthesia, 55 cases) and the control group (propofol anesthesia, 49 cases). No significant difference was found in clinical data between the two groups (P > 0.05, Table 1).

Table 1

Comparison of clinical data between the two groups

Factors Observation group (n = 55) Control group (n = 49) χ 2/t P
Gender, n (%) Male 31 (56.36) 26 (53.06) 0.114 0.736
Female 24 (43.64) 23 (46.94)
Age (years), mean ± SD 7.94 ± 1.61 7.75 ± 1.35 0.648 0.519
ASA classification, n (%) Class I 21 (38.18) 22 (44.90) 0.482 0.488
Class II 34 (61.82) 27 (55.10)
Weight (kg), mean ± SD 25.17 ± 4.32 24.49 ± 4.51 0.785 0.434
BMI (kg/m2), mean ± SD 16.20 ± 2.16 15.82 ± 1.95
Symptom duration (h), mean ± SD 2.13 ± 0.38 2.05 ± 0.34 1.126 0.263
Body temperature on admission (℃), mean ± SD 36.72 ± 0.31 36.65 ± 0.36 1.065 0.289
White blood cell count (*109/L), mean ± SD 13.18 ± 2.04 12.89 ± 2.16 0.704 0.483
C-reactive protein (mg/L), mean ± SD 474.15 ± 41.47 480.28 ± 39.14 0.773 0.442
Procalcitonin (ng/L), mean ± SD 0.31 ± 0.05 0.29 ± 0.06 1.853 0.067

2.2 Inclusion and exclusion criteria

Inclusion criteria included: patients aged 2–12 years; all patients were in American Society of Anesthesiologists (ASA) rate class I–II; appendicitis was diagnosed by comprehensive examination of clinical signs, manifestation, and imaging; patient underwent laparoscopic appendectomy; and the family members of the patients signed the consent form.

After evaluation, 115 children were enrolled in the study and 11 patients were excluded: 2 patients with anemia (hemoglobin <110 g/L); 1 patient with long-term use of sedative drugs; 1 patient with a history of epilepsy; 2 patients with heart, liver, and kidney dysfunction; 1 patient with intracranial arteriovenous malformation; 3 patients with upper respiratory tract infection; and 1 patient was allergic to propofol or sevoflurane and other drugs used in this study.

2.3 Methods

All children were fasted for at least 6 h. Preoperative intravenous hydration and antibiotics (gentamicin plus clindamycin) were prescribed by the on-call emergency pediatrician and/or pediatric surgeon. Normal saline (0.9%) was used throughout the procedure. An anesthesia monitor (General Electric Company, Boston, MA, USA) was used to monitor the child’s vital signs.

To initiate anesthesia, 0.1 mg/kg of midazolam was administered (Jiangsu Enhua Pharmaceutical Co., Ltd), remifentanil at a dosage of 10 μg/kg (Jiangsu Enhua Pharmaceutical Co., Ltd) plus 0.1 mg/kg of cisatracurium (Zhejiang Xianju Pharmaceutical Co., Ltd). Post-induction, the procedure involved endotracheal intubation and the use of an anesthesia device (Yi’an anesthesia machine Aeon7200, Shanghai Hanfei Medical Device Co., Ltd) served as a means for mechanical air circulation. The measured tidal volume ranged between 8 and 10 mL/kg, with the breathing rate occurring 14–20 times per minute.

For anesthesia maintenance, the control group was infused with propofol (1.5 mg/kg/h; Guangdong Jiabao Pharmaceutical Co., Ltd) intravenously, and the observation group was infused with propofol intravenously and treated with sevoflurane by inhalation (2% MAC; Foton Gutian Pharmaceutical Co., Ltd).

During surgery, the bispectral index (one of several techniques used to monitor the depth of anesthesia [11] was maintained between 40 and 60%. In both groups, the patients were given continuous oxygen by mask with an oxygen flow rate of 1 L/min during the procedure.

All cases were operated by the same surgeon, and both anesthesia were turned off at the end of the procedure and neuromuscular blockade was reversed by slow intravenous injection of neostigmine (0.05 mg/kg) and atropine (0.02 mg/kg). When the patient met the criteria for extubation (return of gag reflex, facial expression, and purposeful movement), he or she was successfully extubated and transferred to the postanesthesia care unit.

2.4 Observation indicators

[1] Anesthesia effect: Riker sedation-agitation scale (SAS) [12] was evaluated before anesthesia induction, at the time of the eyelash reflex disappearing, at the beginning of the operation, 5 min after the operation began, 10 min after the operation began, and at the end of the operation. On a scale of 1 to 7, the higher the score, the worse the anesthetic effect [2]. Surgery-related indicators: the operation time, intraoperative blood loss, postoperative eating time, and postoperative ambulation time were compared between the two groups [3]. Indices related to anesthesia and recovery: the disappearance time of pain reflex and eyelash reflex, anesthesia-induced unconsciousness time, spontaneous breathing recovery time, consciousness recovery time, and tracheal extubation time were compared between the two groups. [4] Hemodynamics: pulse oxygen saturation (SPO2), heart rate (HR), and mean arterial pressure (MAP) of the two groups before anesthesia induction (T1), after surgical incision (T2), and at the time of extubation (T3) [5]. Stress indicators: radioimmunoassay was applied to detect cortisol (Cor), noradrenaline (NE), and adrenocorticotropic hormone (ACTH) at each time point (T1, T2, and T3).

2.5 Statistical analysis

The pilot study, which included ten children, utilized the technique for both groups, with five patients per group. The sample size was calculated considering a 15% change in MAP at T3. In order to achieve 90% test efficacy, 5% significance level, and 90% confidence interval, a minimum of 40 patients per group was required. The sample size of this study (55 patients in the observation group and 49 patients in the control group) met the statistical requirements. SPSS 22.0 software was employed to analyze the data. Enumeration data were shown as percent, and differences between groups were compared by Fisher’s exact test or χ 2 test. Measurement data were illustrated as mean ± standard deviation (SD). Normality of continuous variables was checked using Shapiro–Wilk test, and differences between the groups were compared by t-test. Changes in hemodynamic parameters and stress markers over time were analyzed using repeated-measures ANOVA. P < 0.05 emphasized significant statistical difference.

  1. Informed consent: Informed consent was signed by the guardian of every subject.

  2. Ethical approval: This study has been approved by the ethics committee of Yantai Yeda Hospital on date: 2018.06.10 (Ethics approval No. [YD2018-037]).

3 Results

3.1 Comparison of anesthesia effects

The SAS scores of the observation group at the time of the eyelash reflex disappearing (2.89 ± 0.53 vs 3.51 ± 0.61), at the beginning of the operation (3.02 ± 0.58 vs 3.52 ± 0.54), 5 min (2.86 ± 0.61 vs 3.92 ± 0.49) or 10 min after operation began (3.13 ± 0.65 vs 3.65 ± 0.59), and at the end of the operation (3.06 ± 0.57 vs 3.79 ± 0.54) were lower compared with the control group (P < 0.05, Figure 1 and Table 2). These results suggest that combined anesthesia optimizes intraoperative sedation and reduces child agitation.

Figure 1 Comparison of SAS scores between the two groups at different time periods. Comparison of two groups, *P < 0.05.
Figure 1

Comparison of SAS scores between the two groups at different time periods. Comparison of two groups, *P < 0.05.

Table 2

Comparison of anesthesia effects between the two groups

SAS scores at different time points Observation group (n = 55) Control group (n = 49) t P
Before anesthesia induction, mean ± SD 4.38 ± 0.41 4.25± 0.37 1.690 0.094
The time of the eyelash reflex disappearing, mean ± SD 2.89 ± 0.53 3.51 ± 0.61 5.546 <0.001
The beginning of the operation, mean ± SD 3.02 ± 0.58 3.52 ± 0.54 4.533 <0.001
5 min after operation began, mean ± SD 2.86 ± 0.61 3.92 ± 0.49 9.692 <0.001
10 min after operation began, mean ± SD 3.13 ± 0.65 3.65 ± 0.59 4.252 <0.001
The end of the operation, mean ± SD 3.06 ± 0.57 3.79 ± 0.54 6.683 <0.001

3.2 Comparison of surgery-related indicators

No significant difference was found in operation time (41.51 ± 4.75 vs 42.92 ± 3.97), intraoperative blood loss (6.63 ± 1.20 vs 7.09 ± 1.04), postoperative eating time (14.10 ± 2.80 vs 15.22 ± 3.20), and postoperative ambulation time (15.01 ± 1.40 vs 15.31 ± 1.76) between the two groups (P > 0.05, Figure 2).

Figure 2 Comparison of operation-linked indicators between the two groups.
Figure 2

Comparison of operation-linked indicators between the two groups.

3.3 Comparison of anesthesia-related indicators

The disappearance time of pain reflex (59.64 ± 4.49 vs 66.67 ± 5.76) and eyelash reflex (38.07 ± 3.99 vs 40.10 ± 4.22) and anesthesia-induced unconsciousness time (3.01 ± 0.46 vs 3.58 ± 0.59) in the observation group were shorter compared with the control group (P < 0.05, Figure 3). These results suggest that combined anesthesia has a better anesthetic outcome.

Figure 3 Comparison of anesthesia-linked indicators between the two groups. Comparison of two groups, *P < 0.05.
Figure 3

Comparison of anesthesia-linked indicators between the two groups. Comparison of two groups, *P < 0.05.

3.4 Comparison of recovery quality

No significant difference was detected in the recovery time of spontaneous breathing (4.88 ± 1.12 vs 5.16 ± 0.92) and consciousness (6.91 ± 1.52 vs 7.63 ± 1.53) between the two groups (P > 0.05). The tracheal extubation time (6.71 ± 1.42 vs 8.86 ± 1.69) in the observation was shorter compared with the control group (P < 0.05, Figure 4).

Figure 4 Comparison of wake-up quality of the two groups. Comparison of two groups, *P < 0.05.
Figure 4

Comparison of wake-up quality of the two groups. Comparison of two groups, *P < 0.05.

3.5 Comparison of intraoperative hemodynamics

No significant difference was shown in SPO2, HR, and MAP at T1 (SPO2, 97.68 ± 2.45 vs 98.07 ± 2.38; HR, 126.58 ± 3.95 vs 125.39 ± 3.24; MAP, 70.19 ± 2.85 vs 69.05 ± 2.71) between the two group (P > 0.05). No significant difference was detected in SPO2 at T2 (96.92 ± 3.15 vs 97.61 ± 3.79) and T3 (98.05 ± 2.42 vs 98.53 ± 4.64) between the observation and the control groups (P > 0.05). HR and MAP at T2 (HR, 119.68 ± 2.09 vs 121.14 ± 2.18; MAP, 62.04 ± 1.21 vs 63.13 ± 1.03) and T3 (HR, 109.68 ± 4.12 vs 115.37 ± 4.35; MAP, 61.94 ± 2.13 vs 71.16 ± 2.04) in the observation were higher than the control (P < 0.05, Figure 5). These results suggest that combined anesthesia suppresses the hemodynamic response to injurious stimuli.

Figure 5 Comparison of intraoperative hemodynamics between the two groups. Comparison of two groups, *P < 0.05; T1: before anesthesia, T2: after surgical incision, T3: during extubation.
Figure 5

Comparison of intraoperative hemodynamics between the two groups. Comparison of two groups, *P < 0.05; T1: before anesthesia, T2: after surgical incision, T3: during extubation.

3.6 Comparison of stress indicators

No significant difference was presented in Cor, NE, and ACTH at T1 (Cor, 16.53 ± 2.09 vs 16.81 ± 2.13; NE, 319.85 ± 6.31 vs 322.07 ± 7.68; ACTH, 95.16 ± 5.12 vs 96.85 ± 5.05) between the two groups (P > 0.05); Cor, NE, and ACTH at T2 (Cor, 17.28 ± 1.75 vs 18.96 ± 1.59; NE, 334.68 ± 7.65 vs 342.45 ± 7.92; ACTH, 99.07 ± 5.47 vs 105.34 ± 5.63) and T3 (Cor, 22.34 ± 2.03 vs 25.13 ± 2.15; NE, 378.05 ± 7.31 vs 385.16 ± 7.56; ACTH, 145.68 ± 8.12 vs 161.19 ± 8.96) in the observation were lower compared with the control group (P < 0.05, Figure 6). These results suggest that combined anesthesia can reduce the systemic stress response triggered by surgical trauma.

Figure 6 Comparison of stress indicators between the two groups. Comparison of two groups, *P < 0.05; T1: before anesthesia, T2: after surgical incision, T3: during extubation.
Figure 6

Comparison of stress indicators between the two groups. Comparison of two groups, *P < 0.05; T1: before anesthesia, T2: after surgical incision, T3: during extubation.

3.7 Comparison of the incidence of anesthesia-linked adverse reactions

Adverse reaction rates were not significantly different between the groups, being 7.27 and 6.12% (P > 0.05, Table 3). These results indicate that combined anesthesia did not increase the risk of nausea and vomiting, drowsiness, or respiratory depression and has a high safety profile.

Table 3

Comparison of the incidence of anesthesia-related adverse reactions between the two groups

Adverse reactions Observation group (n = 55) Control group (n = 49) χ 2 P
Nausea and vomiting, n (%) 3 (5.45) 1 (2.04)
Somnolence, n (%) 1 (1.82) 1 (2.04)
Respiratory depression, n (%) 0 (0.00) 1 (2.04)
Total, n (%) 4 (7.27) 3 (6.12) 0.055 0.815

4 Discussion

Laparoscopic appendectomy is often applied in clinical treatment of acute appendicitis. Since children have low tolerance, limited cooperation, and slower drug metabolism and excretion, suitable anesthetic drugs should be chosen during surgery to minimize stress response. Propofol is an intravenous anesthetic drug that has been widely used in the induction and maintenance of general anesthesia because of its non-accumulation and short recovery time [13,14]. However, previous studies suggest that the anesthetic effect of propofol alone is insufficient, making the combination with sevoflurane necessary [15]. Sevoflurane is an inhaled anesthetic that offers benefits such as lowering the need for muscle relaxants, quick recovery, effective control, and no respiratory tract irritation. Inhaled through the alveoli, it enters the blood, impacts the central nervous system, and is discharged through the respiratory tract, with a minor amount metabolized into fluoride [16,17]. In this study, sevoflurane was combined with propofol for surgical anesthesia in children with acute appendicitis. The results clarified that the SAS score of the observation group was reduced at the time of the eyelash reflex disappearing, at the beginning of the operation, 5 or 10 min after the operation began, and at the end of the operation. The disappearance time of the pain reflex and eyelash reflex and anesthesia-induced unconsciousness time were shorter in the observation group, indicating that combined anesthesia has better anesthesia effect, which is consistent with a relevant report [18]. Sevoflurane produces few metabolites and does not build up during anesthesia. It mildly depresses respiration in children, potentially shortening the time for spontaneous breathing recovery [19,20]. This research showed that using sevoflurane with propofol did not impact the recovery of spontaneous breathing and consciousness, possibly due to the limited sample size, suggesting a need for further investigation.

Surgery and anesthesia can trigger a stress response, impacting postoperative recovery. Effective anesthesia is essential for enhancing patients’ postoperative stress state [21]. Propofol reduces the stress response by activating GABA receptors, facilitating intracellular chloride ion conductance, decreasing peripheral resistance and venous tone, and directly inhibiting cardiovascular nerve reflexes. However, because of the suboptimal anesthetic effect of propofol, it may increase the stress response to surgical stimuli in humans [22,23]. This study found that Cor, NE, and ACTH at T2 and T3 in the observation group were lower compared with the control group, indicating that sevoflurane combined with propofol anesthesia can reduce the stress response of patients during acute appendicitis surgery. These data align with prior mechanistic studies demonstrating synergistic interactions between propofol and sevoflurane at hypothalamic receptors. Specifically, their combined action suppresses nociceptive signal transduction through dual modulation of glutamatergic and GABAergic pathways, ultimately inhibiting hypothalamic–pituitary–adrenal (HPA) axis hyperactivity and stress hormone secretion [24].

In children with acute appendicitis surgery, perioperative emotional changes, drug stimulation, and invasive operations can lead to large fluctuations in intraoperative hemodynamics. Research has indicated that external factors like surgery can trigger hemodynamic changes, leading to abnormal fluctuations and activating the HPA cortex axis, thereby intensifying the body’s stress response [25,26]. In this study, it was found that combined anesthesia can improve the anesthetic effect and reduce the body’s stress reaction, suggesting that combined anesthesia helps to maintain hemodynamic stability. This study showed that the HR and MAP of the observation group were better than those of the control group at two time points, T2 and T3, suggesting that combined anesthesia is more conducive to maintaining intraoperative hemodynamic stability, mainly because sevoflurane inhalation anesthesia is less irritating to the airway and stabilizes the blood circulation [27]. This study found the time of tracheal extubation in the observation group was shorter than the control group, indicating that intravenous propofol anesthesia combined with sevoflurane inhalation anesthesia was helpful for postoperative extubation. This is mainly because sevoflurane anesthesia can inhibit the cardiovascular stress response caused by tracheal intubation, maintain a stable heart rate, inhibit myocardial excitability, reduce histamine release, lower blood pressure, and thus reduce the difficulty of postoperative extubation [28]. Propofol is similar in chemical structure to a phenol-based free radical scavenger and has a latent protective effect on the kidneys. Its application in general anesthesia can effectively reduce the incidence of adverse reactions of anesthesia [29]. This study found that sevoflurane and propofol did not increase the risk of adverse reactions, pointing to the high safety of using both anesthetics together.

However, this study has limitations. First, the sample size was small and secondary outcomes (e.g., adverse events) may have insufficient statistical validity. Second, postoperative pain scores and long-term neurocognitive function were not assessed. Future more in-depth analyses based on these points should be conducted to confirm or even improve the current findings.

In conclusion, the use of sevoflurane alongside propofol anesthesia in laparoscopic procedures for acute appendicitis in children enhances anesthesia quality and maintains stable hemodynamics and stress conditions. Also, this regimen is considered safe and effective.

Acknowledgments

Not applicable.

  1. Funding information: Authors state no funding involved.

  2. Author contributions: Peng Zhang designed the research study. Peng Zhang and Jun Zhang performed the research. Peng Zhang provided help and advice. Peng Zhang and Feng Chen analyzed the data. Feng Chen wrote the manuscript. Feng Chen reviewed and edited the manuscript. All authors contributed to editorial changes in the manuscript. All authors read and approved the final manuscript.

  3. Conflict of interest: The authors have no conflicts of interest to declare.

  4. Data availability statement: Data are available from the corresponding author on request.

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[29] Xu X, Liu H, Yang J, Zhang M. Comparison analysis of safety profiles and identification of risk factors for postoperative adverse reactions: propofol versus sevoflurane in pediatric anesthesia. Am J Transl Res. 2023;15(7):4658–67.Suche in Google Scholar
Received: 2023-10-25
Revised: 2025-04-16
Accepted: 2025-05-19
Published Online: 2025-12-06

© 2025 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Artikel in diesem Heft

  1. Research Articles
  2. Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
  3. Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
  4. Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
  5. Risk factors for severe adverse drug reactions in hospitalized patients
  6. Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
  7. Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
  8. CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
  9. Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
  10. Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
  11. Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
  12. Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
  13. Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
  14. Association between statin administration and outcome in patients with sepsis: A retrospective study
  15. Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
  16. A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
  17. Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
  18. Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
  19. Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
  20. Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
  21. Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
  22. The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
  23. Health literacy and health-related quality of life: The mediating role of irrational happiness
  24. Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
  25. Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
  26. Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
  27. Clinical analysis of ten cases of HIV infection combined with acute leukemia
  28. Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
  29. Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
  30. Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
  31. Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
  32. Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
  33. The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
  34. The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
  35. Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
  36. Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
  37. Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
  38. The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
  39. Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
  40. A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
  41. A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  42. Identifying early screening factors for depression in middle-aged and older adults: A cohort study
  43. Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
  44. Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
  45. High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
  46. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Investigation of the pathogenic variants induced Sjogren’s syndrome in Turkish population
  128. Nucleotide metabolic abnormalities in post-COVID-19 condition and type 2 diabetes mellitus patients and their association with endocrine dysfunction
  129. TGF-β–Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization
  130. Ultrasound-guided unilateral versus bilateral erector spinae plane block for postoperative analgesia of patients undergoing laparoscopic cholecystectomy
  131. Profiling gut microbiome dynamics in subacute thyroiditis: Implications for pathogenesis, diagnosis, and treatment
  132. Delta neutrophil index, CRP/albumin ratio, procalcitonin, immature granulocytes, and HALP score in acute appendicitis: Best performing biomarker?
  133. Anticancer activity mechanism of novelly synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative on colon cancer cells
  134. H2valdien3 arrests the cell cycle and induces apoptosis of gastric cancer
  135. Prognostic relevance of PRSS2 and its immune correlates in papillary thyroid carcinoma
  136. Association of SGLT2 inhibition with psychiatric disorders: A Mendelian randomization study
  137. Motivational interviewing for alcohol use reduction in Thai patients
  138. Luteolin alleviates oxygen-glucose deprivation/reoxygenation-induced neuron injury by regulating NLRP3/IL-1β signaling
  139. Polyphyllin II inhibits thyroid cancer cell growth by simultaneously inhibiting glycolysis and oxidative phosphorylation
  140. Relationship between the expression of copper death promoting factor SLC31A1 in papillary thyroid carcinoma and clinicopathological indicators and prognosis
  141. CSF2 polarized neutrophils and invaded renal cancer cells in vitro influence
  142. Proton pump inhibitors-induced thrombocytopenia: A systematic literature analysis of case reports
  143. The current status and influence factors of research ability among community nurses: A sequential qualitative–quantitative study
  144. OKAIN: A comprehensive oncology knowledge base for the interpretation of clinically actionable alterations
  145. The relationship between serum CA50, CA242, and SAA levels and clinical pathological characteristics and prognosis in patients with pancreatic cancer
  146. Identification and external validation of a prognostic signature based on hypoxia–glycolysis-related genes for kidney renal clear cell carcinoma
  147. Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility
  148. Relationship of resting echocardiography combined with serum micronutrients to the severity of low-gradient severe aortic stenosis
  149. Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial
  150. The diagnostic performance of machine learning-based FFRCT for coronary artery disease: A meta-analysis
  151. Comparing biofeedback device vs diaphragmatic breathing for bloating relief: A randomized controlled trial
  152. Serum uric acid to albumin ratio and C-reactive protein as predictive biomarkers for chronic total occlusion and coronary collateral circulation quality
  153. Multiple organ scoring systems for predicting in-hospital mortality of sepsis patients in the intensive care unit
  154. Single-cell RNA sequencing data analysis of the inner ear in gentamicin-treated mice via intraperitoneal injection
  155. Suppression of cathepsin B attenuates myocardial injury via limiting cardiomyocyte apoptosis
  156. Influence of sevoflurane combined with propofol anesthesia on the anesthesia effect and adverse reactions in children with acute appendicitis
  157. Review Articles
  158. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  159. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  160. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  161. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  162. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  163. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  164. The application of augmented reality in robotic general surgery: A mini-review
  165. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  166. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  167. Plant polyphenols, terpenes, and terpenoids in oral health
  168. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  169. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  170. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  171. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  172. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  173. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  174. Giant borderline ovarian tumours – review of the literature
  175. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  176. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  177. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  178. Supplement strategies for infertility in overweight women: Evidence and legal insights
  179. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  180. A meta-analysis of the effects of DBS on cognitive function in patients with advanced PD
  181. Protective role of selenium in sepsis: Mechanisms and potential therapeutic strategies
  182. Strategies for hyperkalemia management in dialysis patients: A systematic review
  183. C-reactive protein-to-albumin ratio in peripheral artery disease
  184. Case Reports
  185. Delayed graft function after renal transplantation
  186. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  187. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  188. Giant right atrial hemangioma presenting with ascites: A case report
  189. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  190. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  191. Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report
  192. Coronary artery anomalies: A case of the “malignant” left coronary artery and its surgical management
  193. Rapid Communication
  194. Biological properties of valve materials using RGD and EC
  195. A single oral administration of flavanols enhances short-term memory in mice along with increased brain-derived neurotrophic factor
  196. Letter to the Editor
  197. Role of enhanced external counterpulsation in long COVID
  198. Expression of Concern
  199. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  200. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  201. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  202. Corrigendum
  203. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  204. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  205. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  206. Retraction
  207. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  208. Retraction of: “LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through downregulating SP-A by sponging to miR-424”
  209. Retraction of: “SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways”
  210. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  211. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  212. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  213. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  214. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  215. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  216. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  217. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  218. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  219. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  220. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  221. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  222. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  223. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  224. Red cell distribution width predicts early kidney injury: A NHANES cross-sectional study
  225. Special Issue Diabetes mellitus: pathophysiology, complications & treatment
  226. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  227. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  228. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  229. A review of brain research on T2DM-related cognitive dysfunction
  230. Metformin and estrogen modulation in LABC with T2DM: A 36-month randomized trial
  231. Special Issue Innovative Biomarker Discovery and Precision Medicine in Cancer Diagnostics
  232. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
https://doi.org/10.1515/med-2025-1224
Schlagwörter für diesen Artikel
sevoflurane; propofol; combined anesthesia; acute appendicitis in children; surgical treatment; anesthesia effect; adverse reactions
Creative Commons
BY 4.0

Artikel in diesem Heft

  1. Research Articles
  2. Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
  3. Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
  4. Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
  5. Risk factors for severe adverse drug reactions in hospitalized patients
  6. Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
  7. Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
  8. CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
  9. Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
  10. Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
  11. Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
  12. Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
  13. Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
  14. Association between statin administration and outcome in patients with sepsis: A retrospective study
  15. Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
  16. A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
  17. Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
  18. Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
  19. Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
  20. Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
  21. Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
  22. The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
  23. Health literacy and health-related quality of life: The mediating role of irrational happiness
  24. Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
  25. Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
  26. Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
  27. Clinical analysis of ten cases of HIV infection combined with acute leukemia
  28. Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
  29. Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
  30. Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
  31. Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
  32. Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
  33. The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
  34. The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
  35. Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
  36. Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
  37. Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
  38. The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
  39. Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
  40. A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
  41. A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  42. Identifying early screening factors for depression in middle-aged and older adults: A cohort study
  43. Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
  44. Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
  45. High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
  46. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Investigation of the pathogenic variants induced Sjogren’s syndrome in Turkish population
  128. Nucleotide metabolic abnormalities in post-COVID-19 condition and type 2 diabetes mellitus patients and their association with endocrine dysfunction
  129. TGF-β–Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization
  130. Ultrasound-guided unilateral versus bilateral erector spinae plane block for postoperative analgesia of patients undergoing laparoscopic cholecystectomy
  131. Profiling gut microbiome dynamics in subacute thyroiditis: Implications for pathogenesis, diagnosis, and treatment
  132. Delta neutrophil index, CRP/albumin ratio, procalcitonin, immature granulocytes, and HALP score in acute appendicitis: Best performing biomarker?
  133. Anticancer activity mechanism of novelly synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative on colon cancer cells
  134. H2valdien3 arrests the cell cycle and induces apoptosis of gastric cancer
  135. Prognostic relevance of PRSS2 and its immune correlates in papillary thyroid carcinoma
  136. Association of SGLT2 inhibition with psychiatric disorders: A Mendelian randomization study
  137. Motivational interviewing for alcohol use reduction in Thai patients
  138. Luteolin alleviates oxygen-glucose deprivation/reoxygenation-induced neuron injury by regulating NLRP3/IL-1β signaling
  139. Polyphyllin II inhibits thyroid cancer cell growth by simultaneously inhibiting glycolysis and oxidative phosphorylation
  140. Relationship between the expression of copper death promoting factor SLC31A1 in papillary thyroid carcinoma and clinicopathological indicators and prognosis
  141. CSF2 polarized neutrophils and invaded renal cancer cells in vitro influence
  142. Proton pump inhibitors-induced thrombocytopenia: A systematic literature analysis of case reports
  143. The current status and influence factors of research ability among community nurses: A sequential qualitative–quantitative study
  144. OKAIN: A comprehensive oncology knowledge base for the interpretation of clinically actionable alterations
  145. The relationship between serum CA50, CA242, and SAA levels and clinical pathological characteristics and prognosis in patients with pancreatic cancer
  146. Identification and external validation of a prognostic signature based on hypoxia–glycolysis-related genes for kidney renal clear cell carcinoma
  147. Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility
  148. Relationship of resting echocardiography combined with serum micronutrients to the severity of low-gradient severe aortic stenosis
  149. Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial
  150. The diagnostic performance of machine learning-based FFRCT for coronary artery disease: A meta-analysis
  151. Comparing biofeedback device vs diaphragmatic breathing for bloating relief: A randomized controlled trial
  152. Serum uric acid to albumin ratio and C-reactive protein as predictive biomarkers for chronic total occlusion and coronary collateral circulation quality
  153. Multiple organ scoring systems for predicting in-hospital mortality of sepsis patients in the intensive care unit
  154. Single-cell RNA sequencing data analysis of the inner ear in gentamicin-treated mice via intraperitoneal injection
  155. Suppression of cathepsin B attenuates myocardial injury via limiting cardiomyocyte apoptosis
  156. Influence of sevoflurane combined with propofol anesthesia on the anesthesia effect and adverse reactions in children with acute appendicitis
  157. Review Articles
  158. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  159. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  160. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  161. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  162. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  163. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  164. The application of augmented reality in robotic general surgery: A mini-review
  165. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  166. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  167. Plant polyphenols, terpenes, and terpenoids in oral health
  168. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  169. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  170. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  171. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  172. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  173. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  174. Giant borderline ovarian tumours – review of the literature
  175. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  176. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  177. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  178. Supplement strategies for infertility in overweight women: Evidence and legal insights
  179. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  180. A meta-analysis of the effects of DBS on cognitive function in patients with advanced PD
  181. Protective role of selenium in sepsis: Mechanisms and potential therapeutic strategies
  182. Strategies for hyperkalemia management in dialysis patients: A systematic review
  183. C-reactive protein-to-albumin ratio in peripheral artery disease
  184. Case Reports
  185. Delayed graft function after renal transplantation
  186. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  187. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  188. Giant right atrial hemangioma presenting with ascites: A case report
  189. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  190. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  191. Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report
  192. Coronary artery anomalies: A case of the “malignant” left coronary artery and its surgical management
  193. Rapid Communication
  194. Biological properties of valve materials using RGD and EC
  195. A single oral administration of flavanols enhances short-term memory in mice along with increased brain-derived neurotrophic factor
  196. Letter to the Editor
  197. Role of enhanced external counterpulsation in long COVID
  198. Expression of Concern
  199. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  200. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  201. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  202. Corrigendum
  203. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  204. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  205. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  206. Retraction
  207. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  208. Retraction of: “LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through downregulating SP-A by sponging to miR-424”
  209. Retraction of: “SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways”
  210. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  211. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  212. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  213. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  214. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  215. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  216. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  217. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  218. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  219. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  220. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  221. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  222. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  223. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  224. Red cell distribution width predicts early kidney injury: A NHANES cross-sectional study
  225. Special Issue Diabetes mellitus: pathophysiology, complications & treatment
  226. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  227. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  228. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  229. A review of brain research on T2DM-related cognitive dysfunction
  230. Metformin and estrogen modulation in LABC with T2DM: A 36-month randomized trial
  231. Special Issue Innovative Biomarker Discovery and Precision Medicine in Cancer Diagnostics
  232. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
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Heruntergeladen am 10.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/med-2025-1224/html?lang=de
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