Startseite Low Ang-(1–7) and high des-Arg9 bradykinin serum levels are correlated with cardiovascular risk factors in patients with COVID-19
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Low Ang-(1–7) and high des-Arg9 bradykinin serum levels are correlated with cardiovascular risk factors in patients with COVID-19

  • Farzaneh Rostamzadeh , Hamid Najafipour EMAIL logo , Samira Nakhaei , Rostam Yazdani und Ahmad Alinaghi Langari
Veröffentlicht/Copyright: 4. Juli 2023
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Aus der Zeitschrift Open Medicine Band 18 Heft 1

Abstract

It is predictable that the renin–angiotensin–aldosterone and kinin–kallikrein systems are dysregulated in COVID-19 (COV) patients because SARS-CoV-2 requires ACE2 to cause an infection. This study aimed to assess the serum levels of des-arg(9)-bradykinin (DABK) and angiotensin 1–7 (ang-(1–7)) in patients with COV who had the above-mentioned cardiovascular disease risk factors. In a cross-sectional study, 69 COV patients were selected among patients referred to the main referral center for these patients, in Kerman, Iran, and 73 matched control (non-COV) individuals among individuals who participated in the KERCARD cohort study. Serum levels of DABK and ang-(1–7) were measured by ELISA in the groups of CTL (healthy), HTN, DM, OB, COV, COV + HTN, COV + DM, and COV + OB. Ang-(1–7) levels were lower in the COV + HTN group compared to the HTN group. DABK levels were higher in the COV, HTN, and OB groups and in DM + COV subjects compared to their corresponding control group. The levels of ang-(1–7) and DABK were related to HTN and OB, respectively. According to the findings, we can infer that an increase in DABK production in those with the cardiovascular disease risk factors of diabetes, obesity, and hypertension or a decrease in ang-(1–7) in those with hypertension may contribute to the adverse outcomes of SARS-CoV-2 infection.

Keywords: angiotensin-(1–7); des-Arg (9)-bradykinin; COVID-19; cardiovascular risk factors

1 Introduction

Since the onset of the COVID-19 (COV) pandemic in Wuhan, China, in November 2019, millions of people have suffered from this disease worldwide, and this infection is still circulating across the world [1]. Patients with COV suffer from acute respiratory distress syndrome (ARDS), inflammation, and deleterious secondary effects, such as lung fibrosis, cardiovascular disease, and diabetes [2,3].

As the COV virus needs angiotensin-converting enzyme-type 2 (ACE2), which is one of the members of the renin–angiotensin–aldosterone system (RAAS), to infect cells, the virus possibly changes the activity and levels of ACE2 and disturbs RAAS stability [4]. Indeed, clinical findings in COV patients and experimental findings in mice that were infected with spikes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have indicated RAAS system instability [3,5,6]. The increase in angiotensin II (ang-2) production is associated with severe symptoms and detrimental outcomes such as inflammation, respiratory distress syndrome, and thrombolytic complications [3].

Angiotensin 1–7 (ang-(1–7)), which is one of the products of ACE2 activity, ameliorates the classic effects of RAAS activation, including vasoconstriction, inflammation, oxidative stress, and fibrosis through MAS and AT2 (angiotensin type 2) receptors [7]. The ang-(1–7)/MAS-R signaling pathway is beneficial to several pulmonary diseases, including SARS-CoV-1-mediated lung injuries [8,9].

ACE2 also preserves the stability of the kinin–kallikrein system (KKS) by converting the active form of the bradykinin metabolite, des-arg(9)-bradykinin (DABK) to its inactive metabolites [10]. Extra accumulation of DABK in tissues activates bradykinin receptor B1. Activation of this receptor increases the rate of fluid leakage and mobilization of leukocytes in tissues [11].

According to previous knowledge, KKS regulation is anticipated to be interrupted in COV patients. It has also been established that the RAAS and KKS are dysregulated in hypertension, diabetes, and obesity [12,13,14]. Furthermore, evidence suggests that people with pre-existing comorbidities such as cardiovascular disease, hypertension, diabetes, and obesity are more prone to severe symptoms of COV and have a higher mortality rate [15,16,17]. SARS-CoV-2 binding to ACE2 at the vascular endothelium leads to endothelial dysfunction by increasing oxidative stress and/or inflammatory responses [18]. These alter the production of endothelium-related products such as ang-(1–7) [19]. Disturbances in the balance between ang-(1–7) and ang-2 cause damage to the vascular endothelium. In the previous study, it was observed that the changes in apelin levels, another substrate of ACE2, were associated with arterial O2 saturation, hospitalization period, and degree of lung involvement and pre-existing comorbidities, such as diabetes mellitus, obesity, and hypertension in COVID patients [20]. In this study, we aimed to assess the levels of ang-(1–7) and DABK in COV patients with the abovementioned pre-existing comorbidities in comparison with their non-COV counterparts.

2 Materials and methods

All procedures performed in this study involving human participants were in accordance with the ethical standards of the Declaration of Helsinki. The Ethics Committee of Kerman University of Medical Sciences approved the experimental protocol (Ethic code: IR.KMU.REC.1399.586). The Kerman coronary artery disease risk factors (KERCADR) study that the control groups were selected from, had its own approval (Ethic code: IR.KMU.REC.1393.310). The participants signed a written informed consent form.

The enzyme-linked immunosorbent assay (ELISA) kits of ang-(1–7) and DABK were purchased from Bioassay Technology Laboratory (China) and MyBioSource, Inc (San Diego, USA), respectively.

2.1 Subjects and sampling

In total, 144 subjects were enrolled in this cross-sectional study. Sixty-nine COV patients were selected from patients referred to Afzalipour Hospital in Kerman, Iran, the main referral center in the city, from February to November 2020. Seventy-three individuals who took part in KERCADRS, Phase 3 during the same timespan was chosen and matched as the control group [21]. We did our best for the corresponding control cases to be matched with COV cases in terms of gender, age, and BMI. The follow-up period was 1 to 33 days with a mean of 10.3 days from hospitalization to discharge.

Reverse transcription-polymerase chain reaction (RT-PCR) was used to confirm COV infection. The severity of COV infection was almost identical in test subjects on the first day of hospitalization when the blood samples were taken. The blood samples were centrifuged at 4,000g, and serum samples were separated and kept at −80°C. The serum levels of ang-(1–7) and DABK were determined using ELISA kits according to the manufacturer’s protocols. The study groups were as follows:

(1) Control (CTL, n = 20): healthy individuals who did not have COV or any pre-existing risk factors, (2) HTN: hypertensive (n = 20), (3) DM: diabetic (n = 18), (4) OB: obese (n = 15), (5) COV (COV-19) (n = 20): patients with COV who had no pre-existing risk factor, (6) COV + HTN (n = 18), (7) COV + DM (n = 15), and (8) COV + OB (n = 18). The number of subjects in the groups was chosen according to the following formula [22] with a 5% type 1 error, which is 1.96, and a power of 0.8, which is 0.84. The mean and standard deviation were chosen from a previous study reporting the ang-(1–7) level in normal and gestational hypertensive subjects [23]:

Sample size = r + 1 1 SD 2 Z β + Z α 2 2 d 2 = ( ( 1 + 1 ) / 1 ) 11 2 ( 0 . 89 + 1 . 96 ) 2 8 2 = 15 . 3 .

The hypertensive participants had a systolic blood pressure ≥140 mmHg or a diastolic blood pressure ≥90 mmHg or took antihypertensive medications [24]. Participants with diabetes were chosen from those with a fasting blood sugar level ≥126 mg/dL or who were receiving anti-diabetic medications [25]. Obesity is defined as a body mass index (BMI) ≥ 30 kg/m2 [26]. Since COV increases the risk of hyperglycemia and hypertension [27], COV participants with diabetes and hypertension were selected based on their history of having these risk factors.

2.2 Statistical analysis

The data were analyzed by using SPSS Statistics Version 26. Data in the tables and figures are presented as mean ± SEM for continuous data and as the frequency for categorical variables. After checking for normality in data distribution, two-way ANOVA was performed. The two independent factors were pre-existing disease (with four variables: control, hypertension, diabetes, and obesity) and COV infection (with two categories: yes/no). Differences between continuous variables were analyzed using one-way ANOVA followed by Tukey’s post hoc test. The categorical variables were analyzed using the chi-square test. A linear regression test was used to assess the association between ang-(1–7) and DABK levels with risk factors. Multivariable linear regression was used to assess the predictors of ang-(1–7) and DABK levels in combined groups. The models were adjusted for gender, age, and obesity. Cox regression was performed to evaluate the hazard of death related to different variables. P-values < 0.05 were considered significant.

3 Results

The general features of the studied groups are shown in Table 1. The age and gender of the participants are almost matched among the groups. Only the HTN and COV + HTN groups were significantly older than the CTL group (P < 0.05). In non-HTN groups, the blood pressure was below the level required for a hypertension diagnosis; meanwhile, the arterial systolic and diastolic blood pressure of the COV (P < 0.05), HTN (P < 0.001), COV + HTN (P < 0.001), COV + DM (P < 0.05), and COV + OB (P < 0.05) groups were statistically higher than those of the CTL group. As expected, BMI was higher in the OB and COV + OB groups compared to that in the CTL group (P < 0.001).

Table 1

General characteristics of the study groups

CTL HTN DM OB COV COV + HTN COV + DM COV + OB
Number 20 20 18 15 20 18 15 18
Male n (%) 10 (50) 9 (46.6) 9 (50) 8 (53.3) 10 (50) 9 (50) 7 (46.7) 10 (55.5)
Age (years) 53.9 ± 3.8 63.5 ± 2.5* 53.5 ± 3.8 48.4 ± 4.3 57.6 ± 3.06 63.2 ± 3.02* 53.5 ± 3.7 49.06 ± 3.2
BMI (kg/m2) 21.01 ± 0.48 22.3 ± 0.36 21.2 ± 0.63 31.9 ± 1.29*** 22.6 ± 0.57 24.2 ± 0.87 25.2 ± 0.79 32.4 ± 1.15**
SBP (mmHg) 108 ± 2.3 150 ± 0.2*** 115 ± 2.4 116 ± 3.4 123 ± 4.1* 145 ± 4.5*** 130 ± 6.08** 124 ± 22*
DBP (mmHg) 68 ± 1.7 89 ± 2.4*** 74 ± 1.7 75 ± 1.7 75 ± 2.1 85 ± 3.7** 79 ± 0.3** 82 ± 3.9**

Data are presented in n (%) or mean ± SEM. CTL: control (healthy people), COV: COVID-19, HTN: hypertension, DM: diabetes mellitus, OB: obesity, SBP: systolic blood pressure, DBP: diastolic blood pressure, and DABK: des-arg9-bradykinin. * P < 0.05, ** P < 0.01, *** P < 0.001 vs CTL group. n = 15–20 in each group.

A two-way ANOVA was conducted to examine the interaction effect of COV infection and pre-existing risk factors on the level of ang-(1–7). The study’s findings showed no statistically significant interaction between the effects of COV infection and pre-existing risk factors on ang-(1–7) levels (P = 0.08). Simple main effects analysis showed that the pre-existing risk factors significantly affected the levels of ang-(1–7) (P < 0.01), and there were differences between COV and non-COV subjects (P < 0.05). In patients with hypertension, its level was significantly higher than in the control group (P < 0.05). Ang-(1–7) was lower in patients with COV + HTN (P < 0.05) compared with the HTN group. In the COV, DM, OB, COV + DM, and COV + OB groups, the ang-(1–7) level did not differ compared to the healthy control group (Figure 1).

Figure 1 Ang-(1–7) concentration in the study groups: (a) the overall difference between COV (n = 69) and non-COV (n = 73) participants and (b) the level of ang-(1–7) in COV patients compared to the corresponding non-COV individuals based on the pre-existing risk factors. CTL: control, HTN: hypertension, DM: diabetic mellitus, and OB: obesity. @ P < 0.05 vs non-COV, * P < 0.05 vs CTL, and & P < 0.05 vs HTN group. n = 15–20 in each group.
Figure 1

Ang-(1–7) concentration in the study groups: (a) the overall difference between COV (n = 69) and non-COV (n = 73) participants and (b) the level of ang-(1–7) in COV patients compared to the corresponding non-COV individuals based on the pre-existing risk factors. CTL: control, HTN: hypertension, DM: diabetic mellitus, and OB: obesity. @ P < 0.05 vs non-COV, * P < 0.05 vs CTL, and & P < 0.05 vs HTN group. n = 15–20 in each group.

A two-way ANOVA showed a statistically significant interaction between the effects of COV infection and pre-existing risk factors on the levels of DABK (P < 0.05). A simple main effect analysis showed that the pre-existing risk factors significantly affected the level of DABK (P < 0.001), and the level of DABK was different between COV and non-COV subjects (P < 0.001). The concentration of DABK was higher in obese and diabetic subjects without COV than in healthy people (P < 0.05). Overall, DABK concentration was higher in COV patients than in non-COV subjects (P < 0.001). DABK was higher in control, hypertensive, obese, and diabetic subjects with COV compared with their non-COV counterparts (P < 0.001) (Figure 2).

Figure 2 DABK concentration in the study groups: (a) the overall difference between COV (n = 69) and non-COV (n = 73) participants and (b) the level of DABK in COV patients compared to the corresponding non-COV individuals based on the pre-existing risk factors. CTL: control, HTN: hypertension, DM: diabetic mellitus, and OB: obesity. @@@ P < 0.001 vs non-COV, * P < 0.05, ** P < 0.01, *** P < 0.001 vs CTL, &&& P < 0.001 vs non-COV corresponding group, # P < 0.05 vs DM, ### P < 0.001 vs OB group. n = 15–20 in each group.
Figure 2

DABK concentration in the study groups: (a) the overall difference between COV (n = 69) and non-COV (n = 73) participants and (b) the level of DABK in COV patients compared to the corresponding non-COV individuals based on the pre-existing risk factors. CTL: control, HTN: hypertension, DM: diabetic mellitus, and OB: obesity. @@@ P < 0.001 vs non-COV, * P < 0.05, ** P < 0.01, *** P < 0.001 vs CTL, &&& P < 0.001 vs non-COV corresponding group, # P < 0.05 vs DM, ### P < 0.001 vs OB group. n = 15–20 in each group.

Linear regression examining the correlation between the level of ang-(1–7) and different risk factors showed that the level of ang-(1–7) positively correlated with hypertension when compared with CTL (R 2 = 0.07, P = 0.04) (Figure 3a). In the COV patients, there was a significant correlation between the ang-(1–7) level and COV + HTN (R 2 = 0.085, P = 0.034) (Figure 3b). The level of ang-(1–7) was significantly lower in the COV + HTN group than in the HTN group (R 2 = 0.09, P = 0.04).

Figure 3 The coefficient of determination (R2; bars) indicates the level of ang-(1–7) relationship in the study groups. Comparing the relationships with the CTL group (a), with COV group (b), and in the COV group with the corresponding non-COV group (c), based on the pre-existing risk factors. CTL: control, HTN: hypertension, DM: diabetes mellitus, and OB: obesity. * P < 0.05 vs non-COV (or CTL) group, # P < 0.05 vs COV group, & P < 0.05 vs counterpart group. n = 15–20 in each group.
Figure 3

The coefficient of determination (R2; bars) indicates the level of ang-(1–7) relationship in the study groups. Comparing the relationships with the CTL group (a), with COV group (b), and in the COV group with the corresponding non-COV group (c), based on the pre-existing risk factors. CTL: control, HTN: hypertension, DM: diabetes mellitus, and OB: obesity. * P < 0.05 vs non-COV (or CTL) group, # P < 0.05 vs COV group, & P < 0.05 vs counterpart group. n = 15–20 in each group.

The level of DABK positively correlated with diabetes (R 2 = 0.15, P = 0.009), obesity (R 2 = 0.10, P = 0.02), COV (R 2 = 0.24, P < 0.001), COV + HTN (R 2 = 0.37, P < 0.001), COV + diabetes (R 2 = 0.65, P < 0.001), and COV + OB (R 2 = 0.40, P < 0.001), when compared with CTL (Figure 4a). In COV patients, there was a significant correlation between the DABK level and COV + HTN (R 2 = 0.075, P = 0.04), COV + DM (R 2 = 0.15, P = 0.01), and COV + OB (R 2 = 0.21, P = 0.003) (Figure 4b). DABK was higher in hypertensive (R 2 = 0.18, P = 0.008), obese (R 2 = 0.26, P = 0.001), and diabetic (R 2 = 0.52, P = 0.001) subjects with COV compared with their non-COV counterparts (Figure 4).

Figure 4 The coefficient of determination (R2; bars) indicates the level of the DABK relationship in the study groups. Comparing with the CTL group (a), with the COV group (b), and the COV group with the corresponding non-COV group (c), based on the pre-existing risk factors. CTL: control, HTN: hypertension, DM: diabetic mellitus, and OB: obesity. * P < 0.05, ** P < 0.01, *** P < 0.001 vs non-COV (or CTL) group, # P < 0.05, ## P < 0.01 vs the COV group. && P < 0.01 and &&& P < 0.001 vs the counterpart group. n = 15–20 in each group.
Figure 4

The coefficient of determination (R2; bars) indicates the level of the DABK relationship in the study groups. Comparing with the CTL group (a), with the COV group (b), and the COV group with the corresponding non-COV group (c), based on the pre-existing risk factors. CTL: control, HTN: hypertension, DM: diabetic mellitus, and OB: obesity. * P < 0.05, ** P < 0.01, *** P < 0.001 vs non-COV (or CTL) group, # P < 0.05, ## P < 0.01 vs the COV group. && P < 0.01 and &&& P < 0.001 vs the counterpart group. n = 15–20 in each group.

A multiple regression analysis was carried out to find the predictors of changes in ang-(1–7) and DABK in serum. The results indicated that the model explains 8% (R 2 = 0.08, P = 0.04) and 9% (R 2 = 0.09, P = 0.01) of the alterations in ang-(1–7) and DABK levels, respectively. The level of DABK is associated with OB (P < 0.001), and the level of ang-(1–7) is associated with HTN (P < 0.001) (Table 2).

Table 2

Multiple linear regression of the level of ang-(1–7) or DABK, as dependent variables, with age, OB, DM, HTN, gender, and serum DABK or ang-(1–7) level

Dependent variable Predictor Beta P value
Ang-(1–7) HTN 18.413 0.001
Age 0.049 0.749
OB 3.117 0.583
DM 0.351 0.948
Gender −3.039 0.529
DABK −0.003 0.608
DABK HTN 53.366 0.616
Age 3.182 0.284
OB 396.548 0.001
DM 1.794 0.754
Gender 9.939 0.284
Ang-(1–7) −0.832 0.608

DM: diabetes mellitus, DABK: des-arg9-bradykinin, DM: diabetes mellitus, HTN: hypertension, and OB: obesity.

Up to the end of follow-up, 8.1% of the patients died due to COV. Cox regression indicated that the hazard of death was not dependent on gender, age, DM, OB, and HTN (Table 3).

Table 3

Cox proportional Hazard model on the survival of COVID-19 patients with different risk factors (being male and having COV were used as reference)

Variable Hazard ratio (HR) 95% CI P value
Gender 0.46 0.02–3.34 0.51
Age 0.97 0.78–1.17 0.39
HTN 1.27 0.63–2.49 0.48
DM 1.50 0.70–3.18 0.28
OB 0.98 0.42–2.26 0.96
DABK 1.00 1.0–1.02 0.81
Ang-(1–7) 1.08 0.97–1.012 0.52
COV + HTN vs COV 4.22 0.48–87 0.22
COV + DM vs COV 1.3 0.03–19 0.86
COV + OB vs COV 4.4 0.15–131.7 0.34

DM: diabetes mellitus, DABK: des-arg9-bradykinin, DM: diabetes mellitus, HTN: hypertension, and OB: obesity.

4 Discussion

The findings of this study indicated that the level of ang-(1–7) was lower and the level of DABK was higher in COV patients, and the pre-existing risk factors influenced these levels. The level of ang-(1–7) was related to HTN, and the level of DABK was related to obesity.

Due to the critical role of ACE2 in SARS-CoV-2 infection, it is proposed that the altered RAAS and KKS stability may lead, in part, to adverse outcomes and increased risk of mortality in COV patients, especially in individuals with pre-existing comorbidities such as hypertension, diabetes, and obesity [15,28,29].

It was suggested that as a consequence of the binding of the SARS-CoV-2 virus to the membrane ACE2, the availability and activity of ACE2 as well as the level of ang-(1–7) is reduced in COV patients [4]. The reduction of ACE2 has been attributed to the binding of the protein spike of SARS-CoV-2 to soluble ACE2. Consistent with our results, a very recent study indicated that ang-(1–7) levels decrease in COV patients [30]. However, our results highlighted the changes in ang-(1–7) levels of COV patients with underlying risk factors. Although the reduction of ang-(1–7) was low, its reduction was significantly associated with HTN. In contrast, another study has shown that ang-(1–7) levels increase in people with COV [6]. The difference may be due to differences in the stage and severity of the disease. Diversity in ang-2 levels has also been observed, depending on the severity of the viral infection [3].

Ang-(1–7) may be useful in treating the cardiopulmonary outcomes of SARS-CoV-2 owing to its antihypertensive, anti-inflammatory, anti-thrombotic, antiarrhythmic, and vasodilator effects [31]. Animal studies have shown that ang-(1–7) levels decrease in ARDS, and its replacement improves lung function by the reduction of oxidative stress and pulmonary fibrosis [32]. The mechanism of action may be the inhibition of ERK1/2 and NF-kB production [33]. Preclinical findings have indicated that ang-(1–7) improves oxygenation and reduces inflammation in ARDS [9,32]. It was observed that ang-(1–7) alleviated hypertension and diabetes by improvement of endothelial function [34]. Since the endothelium is injured in COV patients, it is likely that the endothelial dysfunction is created by dysregulation of protecting factors such as ang-(1–7).

Our study indicated a higher level of ang-(1–7) in hypertensive subjects, probably due to compensatory mechanisms or the effect of the antihypertensive drugs they take. ACE2 expression increased in hypertensive patients who receive angiotensin receptor blockers (ARB) or ACE1 inhibitors [35].

This study showed that the level of DABK was higher in obese and diabetic subjects compared to the healthy control group. Other studies have also reported an increase in DABK in obese and diabetic adults, which was associated with a higher risk of cardiometabolic diseases [14,36]. Therefore, the elevation of DABK may be responsible for unwanted disorders in COV patients, especially in obesity and diabetes conditions. Based on our results, the level of DABK was significantly associated with obesity. It has been proposed that a “bradykinin storm” is responsible for most of the symptoms of COV, including increased vascular permeability and pulmonary edema [37]. Indeed, bradykinin storms may have a more prominent role than cytokine storms, which have been suggested as the main cause of severe COV symptoms [38]. Overproduction of DABK overactivates B1 receptors and leads to the leakage of pulmonary arteries, edema, and cough [37]. In experimental models of endotoxin-induced pneumonia, loss of ACE2 function leads to the accumulation of DABK, activation of B1 receptors, release of pro-inflammatory chemokines and cytokines, such as TNF-α, from the epithelium, and damage to the lungs [39,40].

We acknowledge the limitations of our study as the number of subjects in each group may be small. This was due to the limitations in finding subjects with only one of the pre-existing risk factors. Second, we measured ang-(1–7) and DABK levels once on the first day of admission of the COV patients and did not follow their changes with the progress in the severity of the disease to have a clearer picture of the correlation between the level of these two variables and the disease progression.

5 Conclusion

The level of DABK alters in patients with COV, depending on the pre-existing risk factors such as hypertension, obesity, and diabetes. However, the ang-(1–7) alteration is affected by hypertension. More severe complications in disease symptoms and mortality in patients with these pre-existing risk factors seen in the clinic may be related to alterations of ang-(1–7) and DABK levels. These findings may be useful in devising a more appropriate strategy for treating patients with COV disease.

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  1. Funding information: This work was supported by grants from the Iranian National Science Foundation(INSF, Grant No. 99009916), and Vice-Chancellor for Research and Technology at Kerman University of Medical Sciences, Kerman, Iran (Grant No. IR.KMU.REC.99000764).

  2. Author contributions: FR and HN designed the research. AAL selected the COV patients and collected their blood samples and sera. RY and SN recorded the clinical and CT-scan findings. FR analyzed the data and wrote the manuscript in collaboration with HN. All authors read and approved the final version of the manuscript.

  3. Conflict of interest: The authors declare that they have no conflict of interest.

  4. Data availability statement: Data are available on request from the corresponding author.

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Received: 2023-01-30
Revised: 2023-05-31
Accepted: 2023-05-31
Published Online: 2023-07-04

© 2023 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Artikel in diesem Heft

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  200. Mycophenolate mofetil versus cyclophosphamide plus in patients with connective tissue disease-associated interstitial lung disease: Efficacy and safety analysis
  201. MiR-1278 targets CALD1 and suppresses the progression of gastric cancer via the MAPK pathway
  202. Metabolomic analysis of serum short-chain fatty acid concentrations in a mouse of MPTP-induced Parkinson’s disease after dietary supplementation with branched-chain amino acids
  203. Cimifugin inhibits adipogenesis and TNF-α-induced insulin resistance in 3T3-L1 cells
  204. Predictors of gastrointestinal complaints in patients on metformin therapy
  205. Prescribing patterns in patients with chronic obstructive pulmonary disease and atrial fibrillation
  206. A retrospective analysis of the effect of latent tuberculosis infection on clinical pregnancy outcomes of in vitro fertilization–fresh embryo transferred in infertile women
  207. Appropriateness and clinical outcomes of short sustained low-efficiency dialysis: A national experience
  208. miR-29 regulates metabolism by inhibiting JNK-1 expression in non-obese patients with type 2 diabetes mellitus and NAFLD
  209. Clinical features and management of lymphoepithelial cyst
  210. Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia
  211. ENPP1 ameliorates vascular calcification via inhibiting the osteogenic transformation of VSMCs and generating PPi
  212. Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes
  213. The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study
  214. Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units
  215. Identification of diagnostic immune-related gene biomarkers for predicting heart failure after acute myocardial infarction
  216. Long-term administration of probiotics prevents gastrointestinal mucosal barrier dysfunction in septic mice partly by upregulating the 5-HT degradation pathway
  217. miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor
  218. Diagnostic and prognostic value of MR-pro ADM, procalcitonin, and copeptin in sepsis
  219. Review Articles
  220. Prenatal diagnosis of fetal defects and its implications on the delivery mode
  221. Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis
  222. Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
  223. Saddle pulmonary embolism in the setting of COVID-19 infection: A systematic review of case reports and case series
  224. Vitamin C and epigenetics: A short physiological overview
  225. Ebselen: A promising therapy protecting cardiomyocytes from excess iron in iron-overloaded thalassemia patients
  226. Aspirin versus LMWH for VTE prophylaxis after orthopedic surgery
  227. Mechanism of rhubarb in the treatment of hyperlipidemia: A recent review
  228. Surgical management and outcomes of traumatic global brachial plexus injury: A concise review and our center approach
  229. The progress of autoimmune hepatitis research and future challenges
  230. METTL16 in human diseases: What should we do next?
  231. New insights into the prevention of ureteral stents encrustation
  232. VISTA as a prospective immune checkpoint in gynecological malignant tumors: A review of the literature
  233. Case Reports
  234. Mycobacterium xenopi infection of the kidney and lymph nodes: A case report
  235. Genetic mutation of SLC6A20 (c.1072T > C) in a family with nephrolithiasis: A case report
  236. Chronic hepatitis B complicated with secondary hemochromatosis was cured clinically: A case report
  237. Liver abscess complicated with multiple organ invasive infection caused by hematogenous disseminated hypervirulent Klebsiella pneumoniae: A case report
  238. Urokinase-based lock solutions for catheter salvage: A case of an upcoming kidney transplant recipient
  239. Two case reports of maturity-onset diabetes of the young type 3 caused by the hepatocyte nuclear factor 1α gene mutation
  240. Immune checkpoint inhibitor-related pancreatitis: What is known and what is not
  241. Does total hip arthroplasty result in intercostal nerve injury? A case report and literature review
  242. Clinicopathological characteristics and diagnosis of hepatic sinusoidal obstruction syndrome caused by Tusanqi – Case report and literature review
  243. Synchronous triple primary gastrointestinal malignant tumors treated with laparoscopic surgery: A case report
  244. CT-guided percutaneous microwave ablation combined with bone cement injection for the treatment of transverse metastases: A case report
  245. Malignant hyperthermia: Report on a successful rescue of a case with the highest temperature of 44.2°C
  246. Anesthetic management of fetal pulmonary valvuloplasty: A case report
  247. Rapid Communication
  248. Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
  249. Erratum
  250. Erratum to “Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway”
  251. Erratum to: “Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p”
  252. Retraction
  253. Retraction of “Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients”
  254. Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
  255. Retraction of “miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells”
  256. Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”
  257. Retraction of “circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury”
  258. Retraction of “lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells”
  259. Special issue Linking Pathobiological Mechanisms to Clinical Application for cardiovascular diseases
  260. Effect of cardiac rehabilitation therapy on depressed patients with cardiac insufficiency after cardiac surgery
  261. Special issue The evolving saga of RNAs from bench to bedside - Part I
  262. FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma
  263. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part III
  264. Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer
https://doi.org/10.1515/med-2023-0741
Schlagwörter für diesen Artikel
angiotensin-(1–7); des-Arg (9)-bradykinin; COVID-19; cardiovascular risk factors
Creative Commons
BY 4.0

Artikel in diesem Heft

  1. Research Articles
  2. Exosomes derived from mesenchymal stem cells overexpressing miR-210 inhibits neuronal inflammation and contribute to neurite outgrowth through modulating microglia polarization
  3. Current situation of acute ST-segment elevation myocardial infarction in a county hospital chest pain center during an epidemic of novel coronavirus pneumonia
  4. circ-IARS depletion inhibits the progression of non-small-cell lung cancer by circ-IARS/miR-1252-5p/HDGF ceRNA pathway
  5. circRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma
  6. WDR79 promotes aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) by the suppression of SIRT4
  7. Up-regulation of collagen type V alpha 2 (COL5A2) promotes malignant phenotypes in gastric cancer cell via inducing epithelial–mesenchymal transition (EMT)
  8. Inhibition of TERC inhibits neural apoptosis and inflammation in spinal cord injury through Akt activation and p-38 inhibition via the miR-34a-5p/XBP-1 axis
  9. 3D-printed polyether-ether-ketone/n-TiO2 composite enhances the cytocompatibility and osteogenic differentiation of MC3T3-E1 cells by downregulating miR-154-5p
  10. Propofol-mediated circ_0000735 downregulation restrains tumor growth by decreasing integrin-β1 expression in non-small cell lung cancer
  11. PVT1/miR-16/CCND1 axis regulates gastric cancer progression
  12. Silencing of circ_002136 sensitizes gastric cancer to paclitaxel by targeting the miR-16-5p/HMGA1 axis
  13. Short-term outcomes after simultaneous gastrectomy plus cholecystectomy in gastric cancer: A pooling up analysis
  14. SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways
  15. Molecular mechanism by which the Notch signaling pathway regulates autophagy in a rat model of pulmonary fibrosis in pigeon breeder’s lung
  16. lncRNA TPT1-AS1 promotes cell migration and invasion in esophageal squamous-cell carcinomas by regulating the miR-26a/HMGA1 axis
  17. SIRT1/APE1 promotes the viability of gastric cancer cells by inhibiting p53 to suppress ferroptosis
  18. Glycoprotein non-metastatic melanoma B interacts with epidermal growth factor receptor to regulate neural stem cell survival and differentiation
  19. Treatments for brain metastases from EGFR/ALK-negative/unselected NSCLC: A network meta-analysis
  20. Association of osteoporosis and skeletal muscle loss with serum type I collagen carboxyl-terminal peptide β glypeptide: A cross-sectional study in elder Chinese population
  21. circ_0000376 knockdown suppresses non-small cell lung cancer cell tumor properties by the miR-545-3p/PDPK1 pathway
  22. Delivery in a vertical birth chair supported by freedom of movement during labor: A randomized control trial
  23. UBE2J1 knockdown promotes cell apoptosis in endometrial cancer via regulating PI3K/AKT and MDM2/p53 signaling
  24. Metabolic resuscitation therapy in critically ill patients with sepsis and septic shock: A pilot prospective randomized controlled trial
  25. Lycopene ameliorates locomotor activity and urinary frequency induced by pelvic venous congestion in rats
  26. UHRF1-induced connexin26 methylation is involved in hearing damage triggered by intermittent hypoxia in neonatal rats
  27. LINC00511 promotes melanoma progression by targeting miR-610/NUCB2
  28. Ultra-high-performance liquid chromatography-tandem mass spectrometry analysis of serum metabolomic characteristics in people with different vitamin D levels
  29. Role of Jumonji domain-containing protein D3 and its inhibitor GSK-J4 in Hashimoto’s thyroiditis
  30. circ_0014736 induces GPR4 to regulate the biological behaviors of human placental trophoblast cells through miR-942-5p in preeclampsia
  31. Monitoring of sirolimus in the whole blood samples from pediatric patients with lymphatic anomalies
  32. Effects of osteogenic growth peptide C-terminal pentapeptide and its analogue on bone remodeling in an osteoporosis rat model
  33. A novel autophagy-related long non-coding RNAs signature predicting progression-free interval and I-131 therapy benefits in papillary thyroid carcinoma
  34. WGCNA-based identification of potential targets and pathways in response to treatment in locally advanced breast cancer patients
  35. Radiomics model using preoperative computed tomography angiography images to differentiate new from old emboli of acute lower limb arterial embolism
  36. Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks
  37. Single-arm trial to evaluate the efficacy and safety of baclofen in treatment of intractable hiccup caused by malignant tumor chemotherapy
  38. Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk
  39. Efficacy of immune checkpoint inhibitors in patients with KRAS-mutant advanced non-small cell lung cancer: A retrospective analysis
  40. Pyroptosis-based risk score predicts prognosis and drug sensitivity in lung adenocarcinoma
  41. Upregulation of lncRNA LANCL1-AS1 inhibits the progression of non-small-cell lung cancer via the miR-3680-3p/GMFG axis
  42. CircRANBP17 modulated KDM1A to regulate neuroblastoma progression by sponging miR-27b-3p
  43. Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS9
  44. Downregulation of RBM17 enhances cisplatin sensitivity and inhibits cell invasion in human hypopharyngeal cancer cells
  45. HDAC5-mediated PRAME regulates the proliferation, migration, invasion, and EMT of laryngeal squamous cell carcinoma via the PI3K/AKT/mTOR signaling pathway
  46. The association between sleep duration, quality, and nonalcoholic fatty liver disease: A cross-sectional study
  47. Myostatin silencing inhibits podocyte apoptosis in membranous nephropathy through Smad3/PKA/NOX4 signaling pathway
  48. A novel long noncoding RNA AC125257.1 facilitates colorectal cancer progression by targeting miR-133a-3p/CASC5 axis
  49. Impact of omicron wave and associated control measures in Shanghai on health management and psychosocial well-being of patients with chronic conditions
  50. Clinicopathological characteristics and prognosis of young patients aged ≤45 years old with non-small cell lung cancer
  51. TMT-based comprehensive proteomic profiling identifies serum prognostic signatures of acute myeloid leukemia
  52. The dose limits of teeth protection for patients with nasopharyngeal carcinoma undergoing radiotherapy based on the early oral health-related quality of life
  53. miR-30b-5p targeting GRIN2A inhibits hippocampal damage in epilepsy
  54. Long non-coding RNA AL137789.1 promoted malignant biological behaviors and immune escape of pancreatic carcinoma cells
  55. IRF6 and FGF1 polymorphisms in non-syndromic cleft lip with or without cleft palate in the Polish population
  56. Comprehensive analysis of the role of SFXN family in breast cancer
  57. Efficacy of bronchoscopic intratumoral injection of endostar and cisplatin in lung squamous cell carcinoma patients underwent conventional chemoradiotherapy
  58. Silencing of long noncoding RNA MIAT inhibits the viability and proliferation of breast cancer cells by promoting miR-378a-5p expression
  59. AG1024, an IGF-1 receptor inhibitor, ameliorates renal injury in rats with diabetic nephropathy via the SOCS/JAK2/STAT pathway
  60. Downregulation of KIAA1199 alleviated the activation, proliferation, and migration of hepatic stellate cells by the inhibition of epithelial–mesenchymal transition
  61. Exendin-4 regulates the MAPK and WNT signaling pathways to alleviate the osteogenic inhibition of periodontal ligament stem cells in a high glucose environment
  62. Inhibition of glycolysis represses the growth and alleviates the endoplasmic reticulum stress of breast cancer cells by regulating TMTC3
  63. The function of lncRNA EMX2OS/miR-653-5p and its regulatory mechanism in lung adenocarcinoma
  64. Tectorigenin alleviates the apoptosis and inflammation in spinal cord injury cell model through inhibiting insulin-like growth factor-binding protein 6
  65. Ultrasound examination supporting CT or MRI in the evaluation of cervical lymphadenopathy in patients with irradiation-treated head and neck cancer
  66. F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway
  67. Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis
  68. Long noncoding RNA Mhrt alleviates angiotensin II-induced cardiac hypertrophy phenotypes by mediating the miR-765/Wnt family member 7B pathway
  69. Effect of miR-499-5p/SOX6 axis on atrial fibrosis in rats with atrial fibrillation
  70. Cholesterol induces inflammation and reduces glucose utilization
  71. circ_0004904 regulates the trophoblast cell in preeclampsia via miR-19b-3p/ARRDC3 axis
  72. NECAB3 promotes the migration and invasion of liver cancer cells through HIF-1α/RIT1 signaling pathway
  73. The poor performance of cardiovascular risk scores in identifying patients with idiopathic inflammatory myopathies at high cardiovascular risk
  74. miR-2053 inhibits the growth of ovarian cancer cells by downregulating SOX4
  75. Nucleophosmin 1 associating with engulfment and cell motility protein 1 regulates hepatocellular carcinoma cell chemotaxis and metastasis
  76. α-Hederin regulates macrophage polarization to relieve sepsis-induced lung and liver injuries in mice
  77. Changes of microbiota level in urinary tract infections: A meta-analysis
  78. Identification of key enzalutamide-resistance-related genes in castration-resistant prostate cancer and verification of RAD51 functions
  79. Falls during oxaliplatin-based chemotherapy for gastrointestinal malignancies – (lessons learned from) a prospective study
  80. Outcomes of low-risk birth care during the Covid-19 pandemic: A cohort study from a tertiary care center in Lithuania
  81. Vitamin D protects intestines from liver cirrhosis-induced inflammation and oxidative stress by inhibiting the TLR4/MyD88/NF-κB signaling pathway
  82. Integrated transcriptome analysis identifies APPL1/RPS6KB2/GALK1 as immune-related metastasis factors in breast cancer
  83. Genomic analysis of immunogenic cell death-related subtypes for predicting prognosis and immunotherapy outcomes in glioblastoma multiforme
  84. Circular RNA Circ_0038467 promotes the maturation of miRNA-203 to increase lipopolysaccharide-induced apoptosis of chondrocytes
  85. An economic evaluation of fine-needle cytology as the primary diagnostic tool in the diagnosis of lymphadenopathy
  86. Midazolam impedes lung carcinoma cell proliferation and migration via EGFR/MEK/ERK signaling pathway
  87. Network pharmacology combined with molecular docking and experimental validation to reveal the pharmacological mechanism of naringin against renal fibrosis
  88. PTPN12 down-regulated by miR-146b-3p gene affects the malignant progression of laryngeal squamous cell carcinoma
  89. miR-141-3p accelerates ovarian cancer progression and promotes M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway
  90. lncRNA OIP5-AS1 attenuates the osteoarthritis progression in IL-1β-stimulated chondrocytes
  91. Overexpression of LINC00607 inhibits cell growth and aggressiveness by regulating the miR-1289/EFNA5 axis in non-small-cell lung cancer
  92. Subjective well-being in informal caregivers during the COVID-19 pandemic
  93. Nrf2 protects against myocardial ischemia-reperfusion injury in diabetic rats by inhibiting Drp1-mediated mitochondrial fission
  94. Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2B
  95. Bladder cancer screening: The new selection and prediction model
  96. circNFATC3 facilitated the progression of oral squamous cell carcinoma via the miR-520h/LDHA axis
  97. Prone position effect in intensive care patients with SARS-COV-2 pneumonia
  98. Clinical observation on the efficacy of Tongdu Tuina manipulation in the treatment of primary enuresis in children
  99. Dihydroartemisinin ameliorates cerebral I/R injury in rats via regulating VWF and autophagy-mediated SIRT1/FOXO1 pathway
  100. Knockdown of circ_0113656 assuages oxidized low-density lipoprotein-induced vascular smooth muscle cell injury through the miR-188-3p/IGF2 pathway
  101. Low Ang-(1–7) and high des-Arg9 bradykinin serum levels are correlated with cardiovascular risk factors in patients with COVID-19
  102. Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study
  103. Potential protective effects of Huanglian Jiedu Decoction against COVID-19-associated acute kidney injury: A network-based pharmacological and molecular docking study
  104. Clinical significance of serum MBD3 detection in girls with central precocious puberty
  105. Clinical features of varicella-zoster virus caused neurological diseases detected by metagenomic next-generation sequencing
  106. Collagen treatment of complex anorectal fistula: 3 years follow-up
  107. LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through down-regulating SP-A by sponging to miR-424
  108. Efficacy analysis of empirical bismuth quadruple therapy, high-dose dual therapy, and resistance gene-based triple therapy as a first-line Helicobacter pylori eradication regimen – An open-label, randomized trial
  109. SMOC2 plays a role in heart failure via regulating TGF-β1/Smad3 pathway-mediated autophagy
  110. A prospective cohort study of the impact of chronic disease on fall injuries in middle-aged and older adults
  111. circRNA THBS1 silencing inhibits the malignant biological behavior of cervical cancer cells via the regulation of miR-543/HMGB2 axis
  112. hsa_circ_0000285 sponging miR-582-3p promotes neuroblastoma progression by regulating the Wnt/β-catenin signaling pathway
  113. Long non-coding RNA GNAS-AS1 knockdown inhibits proliferation and epithelial–mesenchymal transition of lung adenocarcinoma cells via the microRNA-433-3p/Rab3A axis
  114. lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation
  115. Twenty-four-color full spectrum flow cytometry panel for minimal residual disease detection in acute myeloid leukemia
  116. Hsa-miR-223-3p participates in the process of anthracycline-induced cardiomyocyte damage by regulating NFIA gene
  117. Anti-inflammatory effect of ApoE23 on Salmonella typhimurium-induced sepsis in mice
  118. Analysis of somatic mutations and key driving factors of cervical cancer progression
  119. Hsa_circ_0028007 regulates the progression of nasopharyngeal carcinoma through the miR-1179/SQLE axis
  120. Variations in sexual function after laparoendoscopic single-site hysterectomy in women with benign gynecologic diseases
  121. Effects of pharmacological delay with roxadustat on multi-territory perforator flap survival in rats
  122. Analysis of heroin effects on calcium channels in rat cardiomyocytes based on transcriptomics and metabolomics
  123. Risk factors of recurrent bacterial vaginosis among women of reproductive age: A cross-sectional study
  124. Alkbh5 plays indispensable roles in maintaining self-renewal of hematopoietic stem cells
  125. Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients
  126. Correlation between microvessel maturity and ISUP grades assessed using contrast-enhanced transrectal ultrasonography in prostate cancer
  127. The protective effect of caffeic acid phenethyl ester in the nephrotoxicity induced by α-cypermethrin
  128. Norepinephrine alleviates cyclosporin A-induced nephrotoxicity by enhancing the expression of SFRP1
  129. Effect of RUNX1/FOXP3 axis on apoptosis of T and B lymphocytes and immunosuppression in sepsis
  130. The function of Foxp1 represses β-adrenergic receptor transcription in the occurrence and development of bladder cancer through STAT3 activity
  131. Risk model and validation of carbapenem-resistant Klebsiella pneumoniae infection in patients with cerebrovascular disease in the ICU
  132. Calycosin protects against chronic prostatitis in rats via inhibition of the p38MAPK/NF-κB pathway
  133. Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia
  134. The safety and immunogenicity to inactivated COVID-19 vaccine in patients with hyperlipemia
  135. Circ-UBR4 regulates the proliferation, migration, inflammation, and apoptosis in ox-LDL-induced vascular smooth muscle cells via miR-515-5p/IGF2 axis
  136. Clinical characteristics of current COVID-19 rehabilitation outpatients in China
  137. Luteolin alleviates ulcerative colitis in rats via regulating immune response, oxidative stress, and metabolic profiling
  138. miR-199a-5p inhibits aortic valve calcification by targeting ATF6 and GRP78 in valve interstitial cells
  139. The application of iliac fascia space block combined with esketamine intravenous general anesthesia in PFNA surgery of the elderly: A prospective, single-center, controlled trial
  140. Elevated blood acetoacetate levels reduce major adverse cardiac and cerebrovascular events risk in acute myocardial infarction
  141. The effects of progesterone on the healing of obstetric anal sphincter damage in female rats
  142. Identification of cuproptosis-related genes for predicting the development of prostate cancer
  143. Lumican silencing ameliorates β-glycerophosphate-mediated vascular smooth muscle cell calcification by attenuating the inhibition of APOB on KIF2C activity
  144. Targeting PTBP1 blocks glutamine metabolism to improve the cisplatin sensitivity of hepatocarcinoma cells through modulating the mRNA stability of glutaminase
  145. A single center prospective study: Influences of different hip flexion angles on the measurement of lumbar spine bone mineral density by dual energy X-ray absorptiometry
  146. Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis
  147. Antibiotics therapy combined with probiotics administered intravaginally for the treatment of bacterial vaginosis: A systematic review and meta-analysis
  148. Construction of a ceRNA network to reveal a vascular invasion associated prognostic model in hepatocellular carcinoma
  149. A pan-cancer analysis of STAT3 expression and genetic alterations in human tumors
  150. A prognostic signature based on seven T-cell-related cell clustering genes in bladder urothelial carcinoma
  151. Pepsin concentration in oral lavage fluid of rabbit reflux model constructed by dilating the lower esophageal sphincter
  152. The antihypertensive felodipine shows synergistic activity with immune checkpoint blockade and inhibits tumor growth via NFAT1 in LUSC
  153. Tanshinone IIA attenuates valvular interstitial cells’ calcification induced by oxidized low density lipoprotein via reducing endoplasmic reticulum stress
  154. AS-IV enhances the antitumor effects of propofol in NSCLC cells by inhibiting autophagy
  155. Establishment of two oxaliplatin-resistant gallbladder cancer cell lines and comprehensive analysis of dysregulated genes
  156. Trial protocol: Feasibility of neuromodulation with connectivity-guided intermittent theta-burst stimulation for improving cognition in multiple sclerosis
  157. LncRNA LINC00592 mediates the promoter methylation of WIF1 to promote the development of bladder cancer
  158. Factors associated with gastrointestinal dysmotility in critically ill patients
  159. Mechanisms by which spinal cord stimulation intervenes in atrial fibrillation: The involvement of the endothelin-1 and nerve growth factor/p75NTR pathways
  160. Analysis of two-gene signatures and related drugs in small-cell lung cancer by bioinformatics
  161. Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1
  162. Menstrual irregularities associated with COVID-19 vaccines among women in Saudi Arabia: A survey during 2022
  163. Ferroptosis involves in Schwann cell death in diabetic peripheral neuropathy
  164. The effect of AQP4 on tau protein aggregation in neurodegeneration and persistent neuroinflammation after cerebral microinfarcts
  165. Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin resistance
  166. Analysis of clinical characteristics in proximal and distal reflux monitoring among patients with gastroesophageal reflux disease
  167. Exosomal circ-0020887 and circ-0009590 as novel biomarkers for the diagnosis and prediction of short-term adverse cardiovascular outcomes in STEMI patients
  168. Upregulated microRNA-429 confers endometrial stromal cell dysfunction by targeting HIF1AN and regulating the HIF1A/VEGF pathway
  169. Bibliometrics and knowledge map analysis of ultrasound-guided regional anesthesia
  170. Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways
  171. D-dimer trends predict COVID-19 patient’s prognosis: A retrospective chart review study
  172. WTAP affects intracranial aneurysm progression by regulating m6A methylation modification
  173. Using of endoscopic polypectomy in patients with diagnosed malignant colorectal polyp – The cross-sectional clinical study
  174. Anti-S100A4 antibody administration alleviates bronchial epithelial–mesenchymal transition in asthmatic mice
  175. Prognostic evaluation of system immune-inflammatory index and prognostic nutritional index in double expressor diffuse large B-cell lymphoma
  176. Prevalence and antibiogram of bacteria causing urinary tract infection among patients with chronic kidney disease
  177. Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?
  178. Identification of disulfidptosis-related genes and immune infiltration in lower-grade glioma
  179. A new technique for uterine-preserving pelvic organ prolapse surgery: Laparoscopic rectus abdominis hysteropexy for uterine prolapse by comparing with traditional techniques
  180. Self-isolation of an Italian long-term care facility during COVID-19 pandemic: A comparison study on care-related infectious episodes
  181. A comparative study on the overlapping effects of clinically applicable therapeutic interventions in patients with central nervous system damage
  182. Low intensity extracorporeal shockwave therapy for chronic pelvic pain syndrome: Long-term follow-up
  183. The diagnostic accuracy of touch imprint cytology for sentinel lymph node metastases of breast cancer: An up-to-date meta-analysis of 4,073 patients
  184. Mortality associated with Sjögren’s syndrome in the United States in the 1999–2020 period: A multiple cause-of-death study
  185. CircMMP11 as a prognostic biomarker mediates miR-361-3p/HMGB1 axis to accelerate malignant progression of hepatocellular carcinoma
  186. Analysis of the clinical characteristics and prognosis of adult de novo acute myeloid leukemia (none APL) with PTPN11 mutations
  187. KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
  188. Evaluation of placental oxygenation by near-infrared spectroscopy in relation to ultrasound maturation grade in physiological term pregnancies
  189. The role of ultrasonographic findings for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2-negative breast cancer
  190. Construction of immunogenic cell death-related molecular subtypes and prognostic signature in colorectal cancer
  191. Long-term prognostic value of high-sensitivity cardiac troponin-I in patients with idiopathic dilated cardiomyopathy
  192. Establishing a novel Fanconi anemia signaling pathway-associated prognostic model and tumor clustering for pediatric acute myeloid leukemia patients
  193. Integrative bioinformatics analysis reveals STAT2 as a novel biomarker of inflammation-related cardiac dysfunction in atrial fibrillation
  194. Adipose-derived stem cells repair radiation-induced chronic lung injury via inhibiting TGF-β1/Smad 3 signaling pathway
  195. Real-world practice of idiopathic pulmonary fibrosis: Results from a 2000–2016 cohort
  196. lncRNA LENGA sponges miR-378 to promote myocardial fibrosis in atrial fibrillation
  197. Diagnostic value of urinary Tamm-Horsfall protein and 24 h urine osmolality for recurrent calcium oxalate stones of the upper urinary tract: Cross-sectional study
  198. The value of color Doppler ultrasonography combined with serum tumor markers in differential diagnosis of gastric stromal tumor and gastric cancer
  199. The spike protein of SARS-CoV-2 induces inflammation and EMT of lung epithelial cells and fibroblasts through the upregulation of GADD45A
  200. Mycophenolate mofetil versus cyclophosphamide plus in patients with connective tissue disease-associated interstitial lung disease: Efficacy and safety analysis
  201. MiR-1278 targets CALD1 and suppresses the progression of gastric cancer via the MAPK pathway
  202. Metabolomic analysis of serum short-chain fatty acid concentrations in a mouse of MPTP-induced Parkinson’s disease after dietary supplementation with branched-chain amino acids
  203. Cimifugin inhibits adipogenesis and TNF-α-induced insulin resistance in 3T3-L1 cells
  204. Predictors of gastrointestinal complaints in patients on metformin therapy
  205. Prescribing patterns in patients with chronic obstructive pulmonary disease and atrial fibrillation
  206. A retrospective analysis of the effect of latent tuberculosis infection on clinical pregnancy outcomes of in vitro fertilization–fresh embryo transferred in infertile women
  207. Appropriateness and clinical outcomes of short sustained low-efficiency dialysis: A national experience
  208. miR-29 regulates metabolism by inhibiting JNK-1 expression in non-obese patients with type 2 diabetes mellitus and NAFLD
  209. Clinical features and management of lymphoepithelial cyst
  210. Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia
  211. ENPP1 ameliorates vascular calcification via inhibiting the osteogenic transformation of VSMCs and generating PPi
  212. Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes
  213. The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study
  214. Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units
  215. Identification of diagnostic immune-related gene biomarkers for predicting heart failure after acute myocardial infarction
  216. Long-term administration of probiotics prevents gastrointestinal mucosal barrier dysfunction in septic mice partly by upregulating the 5-HT degradation pathway
  217. miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor
  218. Diagnostic and prognostic value of MR-pro ADM, procalcitonin, and copeptin in sepsis
  219. Review Articles
  220. Prenatal diagnosis of fetal defects and its implications on the delivery mode
  221. Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis
  222. Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
  223. Saddle pulmonary embolism in the setting of COVID-19 infection: A systematic review of case reports and case series
  224. Vitamin C and epigenetics: A short physiological overview
  225. Ebselen: A promising therapy protecting cardiomyocytes from excess iron in iron-overloaded thalassemia patients
  226. Aspirin versus LMWH for VTE prophylaxis after orthopedic surgery
  227. Mechanism of rhubarb in the treatment of hyperlipidemia: A recent review
  228. Surgical management and outcomes of traumatic global brachial plexus injury: A concise review and our center approach
  229. The progress of autoimmune hepatitis research and future challenges
  230. METTL16 in human diseases: What should we do next?
  231. New insights into the prevention of ureteral stents encrustation
  232. VISTA as a prospective immune checkpoint in gynecological malignant tumors: A review of the literature
  233. Case Reports
  234. Mycobacterium xenopi infection of the kidney and lymph nodes: A case report
  235. Genetic mutation of SLC6A20 (c.1072T > C) in a family with nephrolithiasis: A case report
  236. Chronic hepatitis B complicated with secondary hemochromatosis was cured clinically: A case report
  237. Liver abscess complicated with multiple organ invasive infection caused by hematogenous disseminated hypervirulent Klebsiella pneumoniae: A case report
  238. Urokinase-based lock solutions for catheter salvage: A case of an upcoming kidney transplant recipient
  239. Two case reports of maturity-onset diabetes of the young type 3 caused by the hepatocyte nuclear factor 1α gene mutation
  240. Immune checkpoint inhibitor-related pancreatitis: What is known and what is not
  241. Does total hip arthroplasty result in intercostal nerve injury? A case report and literature review
  242. Clinicopathological characteristics and diagnosis of hepatic sinusoidal obstruction syndrome caused by Tusanqi – Case report and literature review
  243. Synchronous triple primary gastrointestinal malignant tumors treated with laparoscopic surgery: A case report
  244. CT-guided percutaneous microwave ablation combined with bone cement injection for the treatment of transverse metastases: A case report
  245. Malignant hyperthermia: Report on a successful rescue of a case with the highest temperature of 44.2°C
  246. Anesthetic management of fetal pulmonary valvuloplasty: A case report
  247. Rapid Communication
  248. Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
  249. Erratum
  250. Erratum to “Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway”
  251. Erratum to: “Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p”
  252. Retraction
  253. Retraction of “Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients”
  254. Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
  255. Retraction of “miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells”
  256. Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”
  257. Retraction of “circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury”
  258. Retraction of “lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells”
  259. Special issue Linking Pathobiological Mechanisms to Clinical Application for cardiovascular diseases
  260. Effect of cardiac rehabilitation therapy on depressed patients with cardiac insufficiency after cardiac surgery
  261. Special issue The evolving saga of RNAs from bench to bedside - Part I
  262. FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma
  263. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part III
  264. Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer
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Heruntergeladen am 8.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/med-2023-0741/html
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