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Bibliometrics and knowledge map analysis of ultrasound-guided regional anesthesia

  • Gao Manhai , Wei Wei , Hao Xiaolu and Wu Juan EMAIL logo
Published/Copyright: October 13, 2023
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Open Medicine
From the journal Open Medicine Volume 18 Issue 1

Abstract

Through bibliometric analysis, we aim to comprehensively understand the research dynamics in this field, reveal key scientific research achievements and breakthrough discoveries, and provide valuable reference and guidance for future research directions. Utilizing the Web of Science, we retrieved the literature pertaining to ultrasonics-guided regional anesthesiology (1994–2022). CiteSpace and VOSviewer were used for bibliometric and knowledge mapping analysis. Our examination encompassed publication trends, authorship patterns, institutional contributions, frequently occurring keywords, keyword clustering, and emerging terminology trends. Of the 570 papers reviewed, there was a rising trend in publications each year. The main keywords in regional anesthesia were ultrasound guidance, nerve, analgesia, and pain score. Key research areas were regional anesthesia, ultrasound guidance, approach, pain score, and plane block. The U.S. led in research. Stanford University, University of Toronto, and Cork University Hospital were central institutions. Chan V was the top author with 24 articles, while Marhofer P was the most cited at 150 times. Regional anesthesia and pain medicine were the predominant journal in both publications and citations. In conclusion, research in this field consistently grew yearly, and visualization showcased trends in ultrasound-guided regional anesthesia. These visuals provided key bibliometric insights, helping researchers further explore and understand this domain.

Keywords: bibliometrics; ultrasound-guided; regional anesthesia

1 Introduction

Efficient anesthesia assistance plays a pivotal role in alleviating postoperative pain and facilitating a swift recovery process [1]. The fundamental principle in the selection of an anesthesia method is to not only attain the necessary depth of anesthesia for the surgical procedure but also prioritize anesthesia safety. Numerous studies have highlighted the importance of allowing patients a period of awakening after general anesthesia. During this phase, postoperative functional recovery tends to be sluggish, potentially giving rise to a range of postoperative complications [2]. In this context, regional nerve analgesia plays a crucial role in mitigating respiratory and circulatory disturbances, effectively broadening the scope of anesthesia indications while concurrently lowering the likelihood of postoperative complications [3].

The key to regional nerve block analgesia is to give sufficient and safe local anesthesia to the target area. Ultrasound-guided regional anesthesia employs real-time ultrasound imaging to visualize soft tissue anatomical structures, thereby facilitating the precise and rapid localization of the target anesthesia site, enhancing both safety and efficacy. This enables the surgeon to precisely block the specific nerves responsible for motor and sensory functions based on the lesion’s location, thereby fulfilling the surgical requirements [4]. It significantly enhances the precision and success rate of anesthesia while also reducing the overall anesthesia usage when compared to empirically guided nerve blocks or nerve stimulator-guided nerve blocks [5–7]. Researchers are constantly exploring new areas and applications, such as spinal and plexus block anesthesia, and improving postoperative pain management. More and more research focusing on individual differences to develop more personalized anesthesia plans and drug choices, improve anesthesia accuracy and patient safety, reduce complications, and provide more predictable outcomes has important implications for the medical field. Although ultrasound-guided regional anesthesia is a safe and effective technique, a number of contraindications remain, including but not limited to, infection or skin damage, bleeding, allergic reactions, nerve damage, etc. Ultrasound-guided regional anesthesia is widely used in surgery and pain management and has developed rapidly in recent years.

Given its advantages in terms of convenience, visibility, and safety, there is a substantial body of literature dedicated to ultrasound-guided regional anesthesia. To effectively harness and analyze this pertinent data and consequently investigate the developmental landscape of this field, identify key research focal points, and address existing limitations, this study employed CiteSpace and VOSviewer software for bibliometric analysis of relevant literature in the realm of ultrasonics-guided regional anesthesia from 1994 onwards, as indexed on Web of Science. Through bibliometric analysis, we aim to provide in-depth insight into scientific research and clinical practice in the field, drive the further development of knowledge, and promote progress and innovation in the medical field. Bibliometric analysis, as a popular and rigorous method, will help reveal the academic landscape of the field and provide a more solid foundation for related research.

2 Materials and methods

2.1 Data sources

In this study, Web of Science (https://www.webofscience.com/) was selected as the literature retrieval platform and the core collection database of Web of Science was selected. Used as “Ultrasound – Guide (Title) AND regional anesthesia (Topic) AND Article Document Type NOT corpse (Abstract) “Cadaver* (Abstract) NOT dog (Abstract) NOT cat (Abstract) NOT feli* (Abstract)” was selected as the retrieval term, animal experiments and cadaver-based studies were excluded, and Article was selected as the literature type. A total of 570 results were obtained by searching articles published by relevant scholars from 1900 to 2022.

2.2 Research methods

To realize in-depth research and analysis of ultrasound-guided regional anesthesia, two researchers were selected to download the data, and the basic information of the included literature was exported and saved (including the author, publication institution, publication quantity, keywords, title of article, name of source journal, abstract, and other information). Visual analysis software was used to analyze the information of research topics, hot spots, authors, institutions, keywords co-occurrence and cluster analysis, emergence words, and other information.

2.3 Analysis tools

All valid data were collected in Web of Science core collection and imported into Microsoft Excel 2016, VOSviewer1.6.10, and CiteSpace6.1.R2 for visual analysis.

CiteSpace is a visualization software for bibliometric analysis using the Java platform [8]. It is an interactive analysis tool that realizes the visualization task of scientific mapping by combining bibliometrics, visual analysis methods, and data mining algorithms [9]. CiteSpace provides a variety of functional options for bibliometrics, including collaborative network analysis, co-citation analysis, and co-occurrence analysis, and can generate visual maps. Nodes with high centrality (>0.1) in the visualization map are often considered turning points or key points in a domain. When the default number of CiteSpace nodes is greater than 350, centrality computing is disabled. We need to manually click on the “Compute Node Centrality” feature in the node menu.

VOSviewer is an application for building and viewing bibliometric maps. It can be used to build author or journal maps based on collaborative data, or keyword maps based on co-occurrence data. The project provides a viewer that allows for a comprehensive and detailed review of bibliometric maps. Unlike common bibliometrics programs, VOSviewer focuses specifically on graphical representation of bibliometrics, which is particularly useful for displaying large bibliometrics in an easily interpreted manner. VOSviewer can analyze bibliometrics networks, build visual network diagrams, and ultimately achieve a deep and comprehensive understanding of the structure and dynamic development of scientific research. The font size of VOSviewer map node represents the frequency of its occurrence. Each point in the project density visualization has a color that represents the project density for that point. The greater the number of items near a point, the higher the weight of adjacent items, the closer the color of the point to yellow, and vice versa, the closer the color of the point to blue. Different colors of nodes indicate that they belong to different clusters [10].

Microsoft Office Excel 2016 was used to analyze the trend of the number of articles published in the year.

3 Results

3.1 Chronological distribution of literature publication

Statistical analysis was conducted on the temporal distribution of all the included literatures, and the publication temporal distribution of literatures related to ultrasound-guided regional anesthesia research was obtained, as shown in Figure 1.

Figure 1 Volume and year of ultrasound-guided regional anesthesia.
Figure 1

Volume and year of ultrasound-guided regional anesthesia.

According to the statistics on the number of articles published in the included literature, the literature on ultrasound-guided regional anesthesia first appeared in 1994, but there was only one literature in that year. Before 2006, the annual number of articles was basically stable, and after 2007, it showed a rapid growth. In general, in recent years, the related researches in the field of regional anesthesia under the guidance of ultrasound have been increasing year by year, and the research in this field has been gradually concerned by more and more scholars.

3.2 Times cited and publications over time

The 570 references retrieved according to the subject words were cited 9,953 times in total, and 8,901 times excluding self-citation, with an average of 18 times per paper. As can be seen from Figure 2, the number of articles citing literatures in this field has gradually increased since 2006. Citation frequency statistics were performed on the retrieval results. The top 10 references in citation frequency in the field of ultrasound-guided regional anesthesia are listed in Table 1. Literatures with high citation frequency were mainly published after 2007. The title, published in 2018, is “Ultrasound-Guided Transversus Abdominis Plane Block: description of a new technique and comparison with conventional systemic analgesia during laparoscopic Reference “cholecystectomy” was cited the most frequently (258 times), with an average of 18.43 times per year. This article mainly discusses the effect and prospect of ultrasound-guided regional anesthesia.

Figure 2 Times cited and publications over time.
Figure 2

Times cited and publications over time.

Table 1

Top 10 cited references

Title Year Total citations Average per year
1 Ultrasound-guided transversus abdominis plane block: description of a new technique and comparison with conventional systemic analgesia during laparoscopic cholecystectomy 2009 258 18.43
2 Ultrasound-guided supraclavicular approach for regional anesthesia of the brachial-plexus 1994 234 8.07
3 Characterizing novice behavior associated with learning ultrasound-guided peripheral regional anesthesia 2007 222 13.88
4 Ultrasound-guided infraclavicular brachial plexus block 2002 207 9.86
5 Ultrasound-guided supraclavicular brachial plexus block 2003 181 9.05
6 Needle visualization in ultrasound-guided regional anesthesia: challenges and solutions 2008 178 11.87
7 Ultrasound-guided regional anesthesia: Current concepts and future trends 2007 173 10.81
8 Incidence of local anesthetic systemic toxicity and postoperative neurologic symptoms associated with 12,668 ultrasound-guided nerve blocks 2012 163 14.82
9 Ultrasound guided erector spinae plane block reduces postoperative opioid consumption following breast surgery: a randomized controlled study 2018 145 29
10 The ASRA evidence-based medicine assessment of ultrasound-guided regional anesthesia and pain medicine executive summary 2010 134 10.31

3.3 Keywords co-occurrence analysis

VOSviewer software was utilized to generate a visualization map depicting research in the field of regional anesthesia guided by ultrasound. In this map, the font size of keywords corresponds to the frequency of their occurrence, and the primary emphasis is on keyword clustering. Figure 3 exhibits four distinct clusters, encompassing a total of 128 keywords and 5,748 connections. These clusters are color-coded, with the blue cluster featuring 26 keywords, the green cluster comprising 47 keywords, the yellow cluster containing 3 keywords, and the red cluster including 52 keywords. Figure 4 highlights that regional anesthesia emerges as the most frequently occurring keyword, with 126 related keywords associated with it. Notably, the key terms closely associated with regional anesthesia include ultrasound guidance, nerves, analgesia, and pain scores. Table 2 shows the top 10 keywords in terms of frequency and mediating centrality. Regional anesthesia, guidance, and pain are the top 3 in both orders, indicating the importance of these three words.

Figure 3 Keywords co-occurrence analysis.
Figure 3

Keywords co-occurrence analysis.

Figure 4 Keywords with the most occurrences.
Figure 4

Keywords with the most occurrences.

Table 2

Top 10 keywords in terms of number of publications

Count Year Keyword Centrality Year Keyword
1 270 1999 Regional anesthesia 1 0.35 1999 Regional anesthesia
2 116 2003 Guidance 2 0.3 2003 Guidance
3 78 2006 Pain 3 0.2 2006 Pain
4 73 2009 Analgesia 4 0.17 2006 Brachial plexus block
5 70 1999 Surgery 5 0.14 2009 Analgesia
6 62 2006 Brachial plexus block 5 0.14 2002 Anesthesia
7 50 2002 Anesthesia 7 0.13 1999 Surgery
8 45 2006 Children 8 0.11 2008 Complication
9 42 2008 Complication 8 0.11 2009 Nerve block
10 39 2009 Nerve block 10 0.07 2006 Children

3.4 Research hot spot tracking

In Figure 5, the VOSviewer software is used to draw the heat cluster graph of keywords and keywords, which shows that the colors of Regional Anesthesia, Ultrasound guidance, Approach, Pain score, and Plane block are yellow, indicating that these keywords have high research hotspots.

Figure 5 Visualization of hotspot density.
Figure 5

Visualization of hotspot density.

3.5 Research frontier and evolution path

The concept of research frontier marks the development trajectory and direction of a particular problem area. It includes a range of emerging and dynamic questions, as well as potential areas of research. In this particular area of research, the first published literature appeared in 1994, followed by sporadic and scattered articles in subsequent years. Until the last decade, the number of articles in this area of study increased significantly.

Figure 6 depicts the temporal evolution of keywords through CiteSpace software, revealing an evolving field of research characterized by evolving topics such as distress, success, and mentoring. It is worth noting that some of the earlier themes, such as regional anesthesia (the most prominent block), have persisted and remain relevant in current research discourse.

Figure 6 Time chart of keywords.
Figure 6

Time chart of keywords.

3.6 Emergent word analysis

Emergent words are words with high change rate in a specific period of time. Through the analysis of emergent words, we can understand the new research direction and development trend of current field to a certain extent. Keywords in ultrasound-guided regional anesthesia-related clinical research increase rapidly over time as shown in Figure 7.

Figure 7 Emergent word diagram.
Figure 7

Emergent word diagram.

3.7 Characteristics of national/regional cooperation network

Fifty-one countries/regions participated in the research in this field, and CiteSpace software was used to map the scientific knowledge of national/regional cooperative networks. Figure 8 shows that the nodes in the figure show 17 countries/regions with publication quantity ≥10. The top 10 countries in terms of publications are shown in Table 3. The United States published the most, with 153 articles, followed by Canada, Turkey, China, and South Korea. From the perspective of centrality, the United States, Canada, and Austria occupy the leading position in this research field, and many countries/regions have relatively low academic activity in this field, so it is not shown in the map.

Figure 8 Collaborating countries.
Figure 8

Collaborating countries.

Table 3

Top 10 countries and regions in terms of number of publications

Country Count Year Country Centrality Year
1 USA 153 2002 1 USA 0.43 2002
2 Canada 58 2008 2 Canada 0.13 2008
3 Turkey 45 2013 3 Austria 0.11 2006
4 China 38 2015 4 Netherlands 0.07 2008
5 India 32 2010 5 India 0.04 2010
5 South Korea 32 2011 5 Japan 0.04 2009
7 France 27 2010 5 England 0.04 2008
8 Germany 26 2008 5 Belgium 0.04 2010
9 Egypt 25 2014 9 France 0.02 2010
10 Ireland 16 2009 9 Germany 0.02 2008
10 Japan 16 2009

3.8 Characteristics of institutional cooperation network

The collaborative scientific knowledge map of institutions was drawn with CiteSpace software (Figure 9). A total of 377 institutions participated in the research in this field, and the top 10 institutions with publications are shown in Table 4. The nodes in the figure are 12 institutions with publications ≥5.

Figure 9 Organization cooperation network.
Figure 9

Organization cooperation network.

Table 4

Top 10 institutions in terms of number of publications

Institution Count Year
1 Univ Toronto 20 2003
2 Stanford Univ 18 2012
3 Cork Univ Hosp 12 2009
4 Dartmouth Hitchcock Med Ctr 10 2006
4 Univ Calif San Diego 10 2008
6 VA Palo Alto Hlth Care Syst 9 2013
7 Duke Univ 7 2010
8 Lapeyronie Univ Hosp 6 2010
8 Med Univ Vienna 6 2007
8 Harvard Med Sch 6 2017

Node size and data confirm that Stanford University, the University of Toronto and Cork University Hospital have published articles in the top three. The map of institutional collaborative scientific knowledge shows the highest mediating centrality among University Toronto, Cork University Hospital and University California San Diego. The centrality of other institutions is mostly 0, indicating the low degree of cooperation among institutions in this field.

3.9 Co-author analysis

VOSviewer was used to map the collaborative scientific knowledge of authors. The 212 authors included in the literature were clustered and 13 obvious author clusters were mainly formed. As shown in Figure 10, there are certain cooperative relationships among all clusters, but most of the cooperative relationships are mainly within clusters.

Figure 10 Author cluster map.
Figure 10

Author cluster map.

The top 10 authors in terms of publications are shown in Table 5. The author who published the most articles in the field of regional anesthesia under ultrasound guidance was CHAN V, who published 24 related literatures. The most cited author is MARHOFER P, whose studies and publications in the field of ultrasound-guided regional anesthesia have been cited 150 times.

Table 5

Top 10 author in terms of number of publications

Author Count Year Cited author Count Year
1 Chan V 24 2003 1 Marhofer P 150 2005
2 Mariano E 18 2009 2 Sites B 148 2006
3 Brull R 14 2007 3 Neal J 99 2008
4 Kim T 10 2014 4 Chin K 80 2010
5 Howard S 9 2014 5 Chan V 74 2006
6 Kim J 8 2015 6 Perlas A 67 2007
6 Harrison T 8 2014 7 Fredrickson M 64 2009
7 Sites B 7 2006 8 Liu S 55 2010
7 Abbas S 7 2007 8 Gray A 55 2005
7 Marhofer P 7 2006 10 Casati A 53 2006

3.10 Co-citation characteristics of journals

The VOSviewer software was used to create a journal overlay visualization map, and 232 journals reported research in this area. As shown in Figure 11, the closer the node color is to yellow, the higher the impact factor of the journal is.

Figure 11 Co-citation characteristics of journals.
Figure 11

Co-citation characteristics of journals.

Table 6 shows the top 10 journals with the most published and cited articles in the field of Regional Anesthesia under ultrasound. Regional Anesthesia and Pain Medicine has published 77 articles and has been cited 472 times. The second and third most cited are Anesthesia and Analgesia and the British Journal of Anaesthesia, with 418 and 378 citations respectively. The second and third places were Veterinary Anaesthesia and Analgesia and Anesthesia and Analgesia, with 26 and 24 papers published respectively.

Table 6

Top 10 journal in terms of number of publications

Cited journal Count HI IF Journal Count HI IF
1 Regional Anesthesia and Pain Medicine 476 109 3.129 1 Regional Anesthesia and Pain Medicine 71 109 3.129
2 Anesthesia and Analgesia 418 201 2.659 2 Pediatric Anesthesia 24 82 2.282
3 British Journal of Anaesthesia 378 181 4.328 3 Journal of Clinical Anesthesia 22 69 1.998
4 Anesthesiology 324 234 2.64 4 Anesthesia and Analgesia 21 201 2.659
5 Anaesthesia 275 117 2.775 5 Anaesthesia 20 117 2.775
6 Acta Anaesthesiologica Scandinavica 176 107 1.542 5 Journal of Ultrasound in Medicine 20 91 1.922
7 Journal of Clinical Anesthesia 139 69 1.998 7 Journal of Anesthesia 18 44 1.473
8 Canadian Journal of Anesthesia 119 97 3.199 8 Acta Anaesthesiologica Scandinavica 14 107 1.542
9 European Journal of Anaesthesiology 114 76 2.17 9 British Journal of Anaesthesia 12 181 4.328
9 Journal of Anesthesia 114 44 1.473 9 Medicine 12 148 1.644

4 Discussion

Bibliometric analysis is an emerging tool developed in recent years to rapidly explore research structures and trends in targeted topics through statistical methods and visualizations [11]. By identifying relevant nodes, useful information can be extracted from a large amount of information through software analysis [12]. Commonly used bibliometric software, including CiteSpace [13], VOSviewer [14], bibExcel [15], and HistCite [16], are all used for scientific bibliometric analysis. CiteSpace and VOSviewer are the most popular. CiteSpace software can intuitively display the location and size of each node in the knowledge network. By selecting different functions, it can analyze the source regions, researchers, research hotspots, and their evolution of research literatures in related fields [17]. VOSviewer is a software that takes a holistic view of all research subjects and explores research topics across an entire field by selecting different perspectives [10]. In this study, VOSviewer and CiteSpace are used together to give full play to their different advantages.

Anesthesia is one of the most important perioperative operations of surgical patients, and regional anesthesia is an important part of it. Regional anesthesia features the highest analgesic technique [18]. Its key benefits are better analgesia, reduced stress responses, fewer systemic opioid side effects, protection against chronic pain, and improved quality of life [19]. Ultrasound-guided assistance helps to assist anesthesiologists in using regional anesthesia as a safe and effective alternative to traditional general anesthesia [20].

In this study, literature metrology was employed for the visual analysis and examination of 570 previously published non-review articles pertaining to ultrasonics-guided regional anesthesia. Research in this field has been conducted over the course of the 20th and 21st centuries, with an average of 18 citations per included paper. Notably, after 2007, there was an explosive growth in the number of studies, culminating in a peak in 2021. Keyword analysis showed that “regional anesthesia”, “guidance”, and “pain” appeared the most frequently and were most closely related to other words. Regional anesthesia, ultrasound guidance, approach, pain score, and plane block are the five keywords with high research hotspots. The hot research topics are Erector Spinae plane block, Serratus Plane block, Brachial Plexus block, postoperative pain, and Axillary block; clinical research can make its own efforts in these aspects.

The United States has published the most articles in the field of regional anesthesia under the guidance of ultrasound. It is also the country at the center of this research field and has the closest research cooperation and exchange with other countries and regions. There is less cooperation among institutions, and Stanford University, University of Toronto, and Cork Univ Hospital published the most literature. Regional Anesthesia and Pain Medicine are the most widely published and cited journal in the field of ultrasonics-guided Regional Anesthesia. Experts and scholars interested in the subject can find more new developments in this journal.

Visual analysis conducted using CiteSpace and VOSviewer software, while valuable, cannot entirely replace systematic retrieval, and it does have certain limitations that need to be addressed. First, the literature collected for this study spans from 1994 to 2022. Given the continuous updating of literature databases, there may be some discrepancy between the retrieval results of this study and the actual number of relevant publications. Second, this study exclusively includes articles, which constitute a single type of literature. Additionally, the quality of the collected literature may vary significantly, potentially impacting the credibility of the visual analysis. Nevertheless, it is important to recognize that visual analysis based on the available literature serves as a foundational resource for scholars seeking to gain rapid insights into the realm of ultrasonics-guided regional anesthesia.

The exploration of ultrasound-guided regional anesthesia holds significant research value and promises extensive practical applications. Research endeavors within this field exhibit a consistent year-on-year increase. By leveraging CiteSpace and VOSviewer software, we have visualized and analyzed the trends and distinctive features of ultrasound-guided regional anesthesia research. This visual analysis offers valuable bibliometric insights, providing researchers with a solid foundation to delve deeper into this field and advance their understanding.

# These authors contributed equally to this study.

  1. Funding information: First Affiliated Hospital of Baotou Medical College Natural Science Young Talent Program BYJJ-ZRQM-202225.

  2. Author contributions: To ensure the transparency and honesty of the research, the team of authors of this research article hereby state the specific contributions of each author in this research. Gao Manhai, the lead author of this paper, is responsible for study design, data collection and analysis, and writing the first draft of the article. Wei Wei and Hao Xiaolu made important contributions to the experimental design and data collection of the study, assisted in data analysis, and participated in the writing of the first draft of the paper. Wu Juan provided important theoretical support and research framework for this study, participated in the discussion of research design, and reviewed and revised the content of the paper. We acknowledge the different contributions of each author and thank them for their collaboration in this study.

  3. Conflict of interest: The design, data analysis, and results report of this study are independent and objective, without interference from any external interests, and the honesty and reliability of this study.

  4. Data available statement: The data could be obtained from the corresponding authors.

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Received: 2023-03-11
Revised: 2023-09-11
Accepted: 2023-09-11
Published Online: 2023-10-13

© 2023 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  30. circ_0014736 induces GPR4 to regulate the biological behaviors of human placental trophoblast cells through miR-942-5p in preeclampsia
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  35. Radiomics model using preoperative computed tomography angiography images to differentiate new from old emboli of acute lower limb arterial embolism
  36. Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks
  37. Single-arm trial to evaluate the efficacy and safety of baclofen in treatment of intractable hiccup caused by malignant tumor chemotherapy
  38. Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk
  39. Efficacy of immune checkpoint inhibitors in patients with KRAS-mutant advanced non-small cell lung cancer: A retrospective analysis
  40. Pyroptosis-based risk score predicts prognosis and drug sensitivity in lung adenocarcinoma
  41. Upregulation of lncRNA LANCL1-AS1 inhibits the progression of non-small-cell lung cancer via the miR-3680-3p/GMFG axis
  42. CircRANBP17 modulated KDM1A to regulate neuroblastoma progression by sponging miR-27b-3p
  43. Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS9
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  45. HDAC5-mediated PRAME regulates the proliferation, migration, invasion, and EMT of laryngeal squamous cell carcinoma via the PI3K/AKT/mTOR signaling pathway
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  53. miR-30b-5p targeting GRIN2A inhibits hippocampal damage in epilepsy
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  55. IRF6 and FGF1 polymorphisms in non-syndromic cleft lip with or without cleft palate in the Polish population
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  58. Silencing of long noncoding RNA MIAT inhibits the viability and proliferation of breast cancer cells by promoting miR-378a-5p expression
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  67. Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis
  68. Long noncoding RNA Mhrt alleviates angiotensin II-induced cardiac hypertrophy phenotypes by mediating the miR-765/Wnt family member 7B pathway
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  74. miR-2053 inhibits the growth of ovarian cancer cells by downregulating SOX4
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  77. Changes of microbiota level in urinary tract infections: A meta-analysis
  78. Identification of key enzalutamide-resistance-related genes in castration-resistant prostate cancer and verification of RAD51 functions
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  80. Outcomes of low-risk birth care during the Covid-19 pandemic: A cohort study from a tertiary care center in Lithuania
  81. Vitamin D protects intestines from liver cirrhosis-induced inflammation and oxidative stress by inhibiting the TLR4/MyD88/NF-κB signaling pathway
  82. Integrated transcriptome analysis identifies APPL1/RPS6KB2/GALK1 as immune-related metastasis factors in breast cancer
  83. Genomic analysis of immunogenic cell death-related subtypes for predicting prognosis and immunotherapy outcomes in glioblastoma multiforme
  84. Circular RNA Circ_0038467 promotes the maturation of miRNA-203 to increase lipopolysaccharide-induced apoptosis of chondrocytes
  85. An economic evaluation of fine-needle cytology as the primary diagnostic tool in the diagnosis of lymphadenopathy
  86. Midazolam impedes lung carcinoma cell proliferation and migration via EGFR/MEK/ERK signaling pathway
  87. Network pharmacology combined with molecular docking and experimental validation to reveal the pharmacological mechanism of naringin against renal fibrosis
  88. PTPN12 down-regulated by miR-146b-3p gene affects the malignant progression of laryngeal squamous cell carcinoma
  89. miR-141-3p accelerates ovarian cancer progression and promotes M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway
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  92. Subjective well-being in informal caregivers during the COVID-19 pandemic
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  114. lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation
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  116. Hsa-miR-223-3p participates in the process of anthracycline-induced cardiomyocyte damage by regulating NFIA gene
  117. Anti-inflammatory effect of ApoE23 on Salmonella typhimurium-induced sepsis in mice
  118. Analysis of somatic mutations and key driving factors of cervical cancer progression
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  120. Variations in sexual function after laparoendoscopic single-site hysterectomy in women with benign gynecologic diseases
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  131. Risk model and validation of carbapenem-resistant Klebsiella pneumoniae infection in patients with cerebrovascular disease in the ICU
  132. Calycosin protects against chronic prostatitis in rats via inhibition of the p38MAPK/NF-κB pathway
  133. Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia
  134. The safety and immunogenicity to inactivated COVID-19 vaccine in patients with hyperlipemia
  135. Circ-UBR4 regulates the proliferation, migration, inflammation, and apoptosis in ox-LDL-induced vascular smooth muscle cells via miR-515-5p/IGF2 axis
  136. Clinical characteristics of current COVID-19 rehabilitation outpatients in China
  137. Luteolin alleviates ulcerative colitis in rats via regulating immune response, oxidative stress, and metabolic profiling
  138. miR-199a-5p inhibits aortic valve calcification by targeting ATF6 and GRP78 in valve interstitial cells
  139. The application of iliac fascia space block combined with esketamine intravenous general anesthesia in PFNA surgery of the elderly: A prospective, single-center, controlled trial
  140. Elevated blood acetoacetate levels reduce major adverse cardiac and cerebrovascular events risk in acute myocardial infarction
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  143. Lumican silencing ameliorates β-glycerophosphate-mediated vascular smooth muscle cell calcification by attenuating the inhibition of APOB on KIF2C activity
  144. Targeting PTBP1 blocks glutamine metabolism to improve the cisplatin sensitivity of hepatocarcinoma cells through modulating the mRNA stability of glutaminase
  145. A single center prospective study: Influences of different hip flexion angles on the measurement of lumbar spine bone mineral density by dual energy X-ray absorptiometry
  146. Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis
  147. Antibiotics therapy combined with probiotics administered intravaginally for the treatment of bacterial vaginosis: A systematic review and meta-analysis
  148. Construction of a ceRNA network to reveal a vascular invasion associated prognostic model in hepatocellular carcinoma
  149. A pan-cancer analysis of STAT3 expression and genetic alterations in human tumors
  150. A prognostic signature based on seven T-cell-related cell clustering genes in bladder urothelial carcinoma
  151. Pepsin concentration in oral lavage fluid of rabbit reflux model constructed by dilating the lower esophageal sphincter
  152. The antihypertensive felodipine shows synergistic activity with immune checkpoint blockade and inhibits tumor growth via NFAT1 in LUSC
  153. Tanshinone IIA attenuates valvular interstitial cells’ calcification induced by oxidized low density lipoprotein via reducing endoplasmic reticulum stress
  154. AS-IV enhances the antitumor effects of propofol in NSCLC cells by inhibiting autophagy
  155. Establishment of two oxaliplatin-resistant gallbladder cancer cell lines and comprehensive analysis of dysregulated genes
  156. Trial protocol: Feasibility of neuromodulation with connectivity-guided intermittent theta-burst stimulation for improving cognition in multiple sclerosis
  157. LncRNA LINC00592 mediates the promoter methylation of WIF1 to promote the development of bladder cancer
  158. Factors associated with gastrointestinal dysmotility in critically ill patients
  159. Mechanisms by which spinal cord stimulation intervenes in atrial fibrillation: The involvement of the endothelin-1 and nerve growth factor/p75NTR pathways
  160. Analysis of two-gene signatures and related drugs in small-cell lung cancer by bioinformatics
  161. Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1
  162. Menstrual irregularities associated with COVID-19 vaccines among women in Saudi Arabia: A survey during 2022
  163. Ferroptosis involves in Schwann cell death in diabetic peripheral neuropathy
  164. The effect of AQP4 on tau protein aggregation in neurodegeneration and persistent neuroinflammation after cerebral microinfarcts
  165. Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin resistance
  166. Analysis of clinical characteristics in proximal and distal reflux monitoring among patients with gastroesophageal reflux disease
  167. Exosomal circ-0020887 and circ-0009590 as novel biomarkers for the diagnosis and prediction of short-term adverse cardiovascular outcomes in STEMI patients
  168. Upregulated microRNA-429 confers endometrial stromal cell dysfunction by targeting HIF1AN and regulating the HIF1A/VEGF pathway
  169. Bibliometrics and knowledge map analysis of ultrasound-guided regional anesthesia
  170. Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways
  171. D-dimer trends predict COVID-19 patient’s prognosis: A retrospective chart review study
  172. WTAP affects intracranial aneurysm progression by regulating m6A methylation modification
  173. Using of endoscopic polypectomy in patients with diagnosed malignant colorectal polyp – The cross-sectional clinical study
  174. Anti-S100A4 antibody administration alleviates bronchial epithelial–mesenchymal transition in asthmatic mice
  175. Prognostic evaluation of system immune-inflammatory index and prognostic nutritional index in double expressor diffuse large B-cell lymphoma
  176. Prevalence and antibiogram of bacteria causing urinary tract infection among patients with chronic kidney disease
  177. Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?
  178. Identification of disulfidptosis-related genes and immune infiltration in lower-grade glioma
  179. A new technique for uterine-preserving pelvic organ prolapse surgery: Laparoscopic rectus abdominis hysteropexy for uterine prolapse by comparing with traditional techniques
  180. Self-isolation of an Italian long-term care facility during COVID-19 pandemic: A comparison study on care-related infectious episodes
  181. A comparative study on the overlapping effects of clinically applicable therapeutic interventions in patients with central nervous system damage
  182. Low intensity extracorporeal shockwave therapy for chronic pelvic pain syndrome: Long-term follow-up
  183. The diagnostic accuracy of touch imprint cytology for sentinel lymph node metastases of breast cancer: An up-to-date meta-analysis of 4,073 patients
  184. Mortality associated with Sjögren’s syndrome in the United States in the 1999–2020 period: A multiple cause-of-death study
  185. CircMMP11 as a prognostic biomarker mediates miR-361-3p/HMGB1 axis to accelerate malignant progression of hepatocellular carcinoma
  186. Analysis of the clinical characteristics and prognosis of adult de novo acute myeloid leukemia (none APL) with PTPN11 mutations
  187. KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
  188. Evaluation of placental oxygenation by near-infrared spectroscopy in relation to ultrasound maturation grade in physiological term pregnancies
  189. The role of ultrasonographic findings for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2-negative breast cancer
  190. Construction of immunogenic cell death-related molecular subtypes and prognostic signature in colorectal cancer
  191. Long-term prognostic value of high-sensitivity cardiac troponin-I in patients with idiopathic dilated cardiomyopathy
  192. Establishing a novel Fanconi anemia signaling pathway-associated prognostic model and tumor clustering for pediatric acute myeloid leukemia patients
  193. Integrative bioinformatics analysis reveals STAT2 as a novel biomarker of inflammation-related cardiac dysfunction in atrial fibrillation
  194. Adipose-derived stem cells repair radiation-induced chronic lung injury via inhibiting TGF-β1/Smad 3 signaling pathway
  195. Real-world practice of idiopathic pulmonary fibrosis: Results from a 2000–2016 cohort
  196. lncRNA LENGA sponges miR-378 to promote myocardial fibrosis in atrial fibrillation
  197. Diagnostic value of urinary Tamm-Horsfall protein and 24 h urine osmolality for recurrent calcium oxalate stones of the upper urinary tract: Cross-sectional study
  198. The value of color Doppler ultrasonography combined with serum tumor markers in differential diagnosis of gastric stromal tumor and gastric cancer
  199. The spike protein of SARS-CoV-2 induces inflammation and EMT of lung epithelial cells and fibroblasts through the upregulation of GADD45A
  200. Mycophenolate mofetil versus cyclophosphamide plus in patients with connective tissue disease-associated interstitial lung disease: Efficacy and safety analysis
  201. MiR-1278 targets CALD1 and suppresses the progression of gastric cancer via the MAPK pathway
  202. Metabolomic analysis of serum short-chain fatty acid concentrations in a mouse of MPTP-induced Parkinson’s disease after dietary supplementation with branched-chain amino acids
  203. Cimifugin inhibits adipogenesis and TNF-α-induced insulin resistance in 3T3-L1 cells
  204. Predictors of gastrointestinal complaints in patients on metformin therapy
  205. Prescribing patterns in patients with chronic obstructive pulmonary disease and atrial fibrillation
  206. A retrospective analysis of the effect of latent tuberculosis infection on clinical pregnancy outcomes of in vitro fertilization–fresh embryo transferred in infertile women
  207. Appropriateness and clinical outcomes of short sustained low-efficiency dialysis: A national experience
  208. miR-29 regulates metabolism by inhibiting JNK-1 expression in non-obese patients with type 2 diabetes mellitus and NAFLD
  209. Clinical features and management of lymphoepithelial cyst
  210. Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia
  211. ENPP1 ameliorates vascular calcification via inhibiting the osteogenic transformation of VSMCs and generating PPi
  212. Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes
  213. The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study
  214. Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units
  215. Identification of diagnostic immune-related gene biomarkers for predicting heart failure after acute myocardial infarction
  216. Long-term administration of probiotics prevents gastrointestinal mucosal barrier dysfunction in septic mice partly by upregulating the 5-HT degradation pathway
  217. miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor
  218. Diagnostic and prognostic value of MR-pro ADM, procalcitonin, and copeptin in sepsis
  219. Review Articles
  220. Prenatal diagnosis of fetal defects and its implications on the delivery mode
  221. Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis
  222. Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
  223. Saddle pulmonary embolism in the setting of COVID-19 infection: A systematic review of case reports and case series
  224. Vitamin C and epigenetics: A short physiological overview
  225. Ebselen: A promising therapy protecting cardiomyocytes from excess iron in iron-overloaded thalassemia patients
  226. Aspirin versus LMWH for VTE prophylaxis after orthopedic surgery
  227. Mechanism of rhubarb in the treatment of hyperlipidemia: A recent review
  228. Surgical management and outcomes of traumatic global brachial plexus injury: A concise review and our center approach
  229. The progress of autoimmune hepatitis research and future challenges
  230. METTL16 in human diseases: What should we do next?
  231. New insights into the prevention of ureteral stents encrustation
  232. VISTA as a prospective immune checkpoint in gynecological malignant tumors: A review of the literature
  233. Case Reports
  234. Mycobacterium xenopi infection of the kidney and lymph nodes: A case report
  235. Genetic mutation of SLC6A20 (c.1072T > C) in a family with nephrolithiasis: A case report
  236. Chronic hepatitis B complicated with secondary hemochromatosis was cured clinically: A case report
  237. Liver abscess complicated with multiple organ invasive infection caused by hematogenous disseminated hypervirulent Klebsiella pneumoniae: A case report
  238. Urokinase-based lock solutions for catheter salvage: A case of an upcoming kidney transplant recipient
  239. Two case reports of maturity-onset diabetes of the young type 3 caused by the hepatocyte nuclear factor 1α gene mutation
  240. Immune checkpoint inhibitor-related pancreatitis: What is known and what is not
  241. Does total hip arthroplasty result in intercostal nerve injury? A case report and literature review
  242. Clinicopathological characteristics and diagnosis of hepatic sinusoidal obstruction syndrome caused by Tusanqi – Case report and literature review
  243. Synchronous triple primary gastrointestinal malignant tumors treated with laparoscopic surgery: A case report
  244. CT-guided percutaneous microwave ablation combined with bone cement injection for the treatment of transverse metastases: A case report
  245. Malignant hyperthermia: Report on a successful rescue of a case with the highest temperature of 44.2°C
  246. Anesthetic management of fetal pulmonary valvuloplasty: A case report
  247. Rapid Communication
  248. Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
  249. Erratum
  250. Erratum to “Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway”
  251. Erratum to: “Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p”
  252. Retraction
  253. Retraction of “Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients”
  254. Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
  255. Retraction of “miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells”
  256. Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”
  257. Retraction of “circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury”
  258. Retraction of “lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells”
  259. Special issue Linking Pathobiological Mechanisms to Clinical Application for cardiovascular diseases
  260. Effect of cardiac rehabilitation therapy on depressed patients with cardiac insufficiency after cardiac surgery
  261. Special issue The evolving saga of RNAs from bench to bedside - Part I
  262. FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma
  263. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part III
  264. Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer
https://doi.org/10.1515/med-2023-0813
Keywords for this article
bibliometrics; ultrasound-guided; regional anesthesia
Creative Commons
BY 4.0

Articles in the same Issue

  1. Research Articles
  2. Exosomes derived from mesenchymal stem cells overexpressing miR-210 inhibits neuronal inflammation and contribute to neurite outgrowth through modulating microglia polarization
  3. Current situation of acute ST-segment elevation myocardial infarction in a county hospital chest pain center during an epidemic of novel coronavirus pneumonia
  4. circ-IARS depletion inhibits the progression of non-small-cell lung cancer by circ-IARS/miR-1252-5p/HDGF ceRNA pathway
  5. circRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma
  6. WDR79 promotes aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) by the suppression of SIRT4
  7. Up-regulation of collagen type V alpha 2 (COL5A2) promotes malignant phenotypes in gastric cancer cell via inducing epithelial–mesenchymal transition (EMT)
  8. Inhibition of TERC inhibits neural apoptosis and inflammation in spinal cord injury through Akt activation and p-38 inhibition via the miR-34a-5p/XBP-1 axis
  9. 3D-printed polyether-ether-ketone/n-TiO2 composite enhances the cytocompatibility and osteogenic differentiation of MC3T3-E1 cells by downregulating miR-154-5p
  10. Propofol-mediated circ_0000735 downregulation restrains tumor growth by decreasing integrin-β1 expression in non-small cell lung cancer
  11. PVT1/miR-16/CCND1 axis regulates gastric cancer progression
  12. Silencing of circ_002136 sensitizes gastric cancer to paclitaxel by targeting the miR-16-5p/HMGA1 axis
  13. Short-term outcomes after simultaneous gastrectomy plus cholecystectomy in gastric cancer: A pooling up analysis
  14. SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways
  15. Molecular mechanism by which the Notch signaling pathway regulates autophagy in a rat model of pulmonary fibrosis in pigeon breeder’s lung
  16. lncRNA TPT1-AS1 promotes cell migration and invasion in esophageal squamous-cell carcinomas by regulating the miR-26a/HMGA1 axis
  17. SIRT1/APE1 promotes the viability of gastric cancer cells by inhibiting p53 to suppress ferroptosis
  18. Glycoprotein non-metastatic melanoma B interacts with epidermal growth factor receptor to regulate neural stem cell survival and differentiation
  19. Treatments for brain metastases from EGFR/ALK-negative/unselected NSCLC: A network meta-analysis
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  21. circ_0000376 knockdown suppresses non-small cell lung cancer cell tumor properties by the miR-545-3p/PDPK1 pathway
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  23. UBE2J1 knockdown promotes cell apoptosis in endometrial cancer via regulating PI3K/AKT and MDM2/p53 signaling
  24. Metabolic resuscitation therapy in critically ill patients with sepsis and septic shock: A pilot prospective randomized controlled trial
  25. Lycopene ameliorates locomotor activity and urinary frequency induced by pelvic venous congestion in rats
  26. UHRF1-induced connexin26 methylation is involved in hearing damage triggered by intermittent hypoxia in neonatal rats
  27. LINC00511 promotes melanoma progression by targeting miR-610/NUCB2
  28. Ultra-high-performance liquid chromatography-tandem mass spectrometry analysis of serum metabolomic characteristics in people with different vitamin D levels
  29. Role of Jumonji domain-containing protein D3 and its inhibitor GSK-J4 in Hashimoto’s thyroiditis
  30. circ_0014736 induces GPR4 to regulate the biological behaviors of human placental trophoblast cells through miR-942-5p in preeclampsia
  31. Monitoring of sirolimus in the whole blood samples from pediatric patients with lymphatic anomalies
  32. Effects of osteogenic growth peptide C-terminal pentapeptide and its analogue on bone remodeling in an osteoporosis rat model
  33. A novel autophagy-related long non-coding RNAs signature predicting progression-free interval and I-131 therapy benefits in papillary thyroid carcinoma
  34. WGCNA-based identification of potential targets and pathways in response to treatment in locally advanced breast cancer patients
  35. Radiomics model using preoperative computed tomography angiography images to differentiate new from old emboli of acute lower limb arterial embolism
  36. Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks
  37. Single-arm trial to evaluate the efficacy and safety of baclofen in treatment of intractable hiccup caused by malignant tumor chemotherapy
  38. Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk
  39. Efficacy of immune checkpoint inhibitors in patients with KRAS-mutant advanced non-small cell lung cancer: A retrospective analysis
  40. Pyroptosis-based risk score predicts prognosis and drug sensitivity in lung adenocarcinoma
  41. Upregulation of lncRNA LANCL1-AS1 inhibits the progression of non-small-cell lung cancer via the miR-3680-3p/GMFG axis
  42. CircRANBP17 modulated KDM1A to regulate neuroblastoma progression by sponging miR-27b-3p
  43. Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS9
  44. Downregulation of RBM17 enhances cisplatin sensitivity and inhibits cell invasion in human hypopharyngeal cancer cells
  45. HDAC5-mediated PRAME regulates the proliferation, migration, invasion, and EMT of laryngeal squamous cell carcinoma via the PI3K/AKT/mTOR signaling pathway
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  48. A novel long noncoding RNA AC125257.1 facilitates colorectal cancer progression by targeting miR-133a-3p/CASC5 axis
  49. Impact of omicron wave and associated control measures in Shanghai on health management and psychosocial well-being of patients with chronic conditions
  50. Clinicopathological characteristics and prognosis of young patients aged ≤45 years old with non-small cell lung cancer
  51. TMT-based comprehensive proteomic profiling identifies serum prognostic signatures of acute myeloid leukemia
  52. The dose limits of teeth protection for patients with nasopharyngeal carcinoma undergoing radiotherapy based on the early oral health-related quality of life
  53. miR-30b-5p targeting GRIN2A inhibits hippocampal damage in epilepsy
  54. Long non-coding RNA AL137789.1 promoted malignant biological behaviors and immune escape of pancreatic carcinoma cells
  55. IRF6 and FGF1 polymorphisms in non-syndromic cleft lip with or without cleft palate in the Polish population
  56. Comprehensive analysis of the role of SFXN family in breast cancer
  57. Efficacy of bronchoscopic intratumoral injection of endostar and cisplatin in lung squamous cell carcinoma patients underwent conventional chemoradiotherapy
  58. Silencing of long noncoding RNA MIAT inhibits the viability and proliferation of breast cancer cells by promoting miR-378a-5p expression
  59. AG1024, an IGF-1 receptor inhibitor, ameliorates renal injury in rats with diabetic nephropathy via the SOCS/JAK2/STAT pathway
  60. Downregulation of KIAA1199 alleviated the activation, proliferation, and migration of hepatic stellate cells by the inhibition of epithelial–mesenchymal transition
  61. Exendin-4 regulates the MAPK and WNT signaling pathways to alleviate the osteogenic inhibition of periodontal ligament stem cells in a high glucose environment
  62. Inhibition of glycolysis represses the growth and alleviates the endoplasmic reticulum stress of breast cancer cells by regulating TMTC3
  63. The function of lncRNA EMX2OS/miR-653-5p and its regulatory mechanism in lung adenocarcinoma
  64. Tectorigenin alleviates the apoptosis and inflammation in spinal cord injury cell model through inhibiting insulin-like growth factor-binding protein 6
  65. Ultrasound examination supporting CT or MRI in the evaluation of cervical lymphadenopathy in patients with irradiation-treated head and neck cancer
  66. F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway
  67. Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis
  68. Long noncoding RNA Mhrt alleviates angiotensin II-induced cardiac hypertrophy phenotypes by mediating the miR-765/Wnt family member 7B pathway
  69. Effect of miR-499-5p/SOX6 axis on atrial fibrosis in rats with atrial fibrillation
  70. Cholesterol induces inflammation and reduces glucose utilization
  71. circ_0004904 regulates the trophoblast cell in preeclampsia via miR-19b-3p/ARRDC3 axis
  72. NECAB3 promotes the migration and invasion of liver cancer cells through HIF-1α/RIT1 signaling pathway
  73. The poor performance of cardiovascular risk scores in identifying patients with idiopathic inflammatory myopathies at high cardiovascular risk
  74. miR-2053 inhibits the growth of ovarian cancer cells by downregulating SOX4
  75. Nucleophosmin 1 associating with engulfment and cell motility protein 1 regulates hepatocellular carcinoma cell chemotaxis and metastasis
  76. α-Hederin regulates macrophage polarization to relieve sepsis-induced lung and liver injuries in mice
  77. Changes of microbiota level in urinary tract infections: A meta-analysis
  78. Identification of key enzalutamide-resistance-related genes in castration-resistant prostate cancer and verification of RAD51 functions
  79. Falls during oxaliplatin-based chemotherapy for gastrointestinal malignancies – (lessons learned from) a prospective study
  80. Outcomes of low-risk birth care during the Covid-19 pandemic: A cohort study from a tertiary care center in Lithuania
  81. Vitamin D protects intestines from liver cirrhosis-induced inflammation and oxidative stress by inhibiting the TLR4/MyD88/NF-κB signaling pathway
  82. Integrated transcriptome analysis identifies APPL1/RPS6KB2/GALK1 as immune-related metastasis factors in breast cancer
  83. Genomic analysis of immunogenic cell death-related subtypes for predicting prognosis and immunotherapy outcomes in glioblastoma multiforme
  84. Circular RNA Circ_0038467 promotes the maturation of miRNA-203 to increase lipopolysaccharide-induced apoptosis of chondrocytes
  85. An economic evaluation of fine-needle cytology as the primary diagnostic tool in the diagnosis of lymphadenopathy
  86. Midazolam impedes lung carcinoma cell proliferation and migration via EGFR/MEK/ERK signaling pathway
  87. Network pharmacology combined with molecular docking and experimental validation to reveal the pharmacological mechanism of naringin against renal fibrosis
  88. PTPN12 down-regulated by miR-146b-3p gene affects the malignant progression of laryngeal squamous cell carcinoma
  89. miR-141-3p accelerates ovarian cancer progression and promotes M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway
  90. lncRNA OIP5-AS1 attenuates the osteoarthritis progression in IL-1β-stimulated chondrocytes
  91. Overexpression of LINC00607 inhibits cell growth and aggressiveness by regulating the miR-1289/EFNA5 axis in non-small-cell lung cancer
  92. Subjective well-being in informal caregivers during the COVID-19 pandemic
  93. Nrf2 protects against myocardial ischemia-reperfusion injury in diabetic rats by inhibiting Drp1-mediated mitochondrial fission
  94. Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2B
  95. Bladder cancer screening: The new selection and prediction model
  96. circNFATC3 facilitated the progression of oral squamous cell carcinoma via the miR-520h/LDHA axis
  97. Prone position effect in intensive care patients with SARS-COV-2 pneumonia
  98. Clinical observation on the efficacy of Tongdu Tuina manipulation in the treatment of primary enuresis in children
  99. Dihydroartemisinin ameliorates cerebral I/R injury in rats via regulating VWF and autophagy-mediated SIRT1/FOXO1 pathway
  100. Knockdown of circ_0113656 assuages oxidized low-density lipoprotein-induced vascular smooth muscle cell injury through the miR-188-3p/IGF2 pathway
  101. Low Ang-(1–7) and high des-Arg9 bradykinin serum levels are correlated with cardiovascular risk factors in patients with COVID-19
  102. Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study
  103. Potential protective effects of Huanglian Jiedu Decoction against COVID-19-associated acute kidney injury: A network-based pharmacological and molecular docking study
  104. Clinical significance of serum MBD3 detection in girls with central precocious puberty
  105. Clinical features of varicella-zoster virus caused neurological diseases detected by metagenomic next-generation sequencing
  106. Collagen treatment of complex anorectal fistula: 3 years follow-up
  107. LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through down-regulating SP-A by sponging to miR-424
  108. Efficacy analysis of empirical bismuth quadruple therapy, high-dose dual therapy, and resistance gene-based triple therapy as a first-line Helicobacter pylori eradication regimen – An open-label, randomized trial
  109. SMOC2 plays a role in heart failure via regulating TGF-β1/Smad3 pathway-mediated autophagy
  110. A prospective cohort study of the impact of chronic disease on fall injuries in middle-aged and older adults
  111. circRNA THBS1 silencing inhibits the malignant biological behavior of cervical cancer cells via the regulation of miR-543/HMGB2 axis
  112. hsa_circ_0000285 sponging miR-582-3p promotes neuroblastoma progression by regulating the Wnt/β-catenin signaling pathway
  113. Long non-coding RNA GNAS-AS1 knockdown inhibits proliferation and epithelial–mesenchymal transition of lung adenocarcinoma cells via the microRNA-433-3p/Rab3A axis
  114. lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation
  115. Twenty-four-color full spectrum flow cytometry panel for minimal residual disease detection in acute myeloid leukemia
  116. Hsa-miR-223-3p participates in the process of anthracycline-induced cardiomyocyte damage by regulating NFIA gene
  117. Anti-inflammatory effect of ApoE23 on Salmonella typhimurium-induced sepsis in mice
  118. Analysis of somatic mutations and key driving factors of cervical cancer progression
  119. Hsa_circ_0028007 regulates the progression of nasopharyngeal carcinoma through the miR-1179/SQLE axis
  120. Variations in sexual function after laparoendoscopic single-site hysterectomy in women with benign gynecologic diseases
  121. Effects of pharmacological delay with roxadustat on multi-territory perforator flap survival in rats
  122. Analysis of heroin effects on calcium channels in rat cardiomyocytes based on transcriptomics and metabolomics
  123. Risk factors of recurrent bacterial vaginosis among women of reproductive age: A cross-sectional study
  124. Alkbh5 plays indispensable roles in maintaining self-renewal of hematopoietic stem cells
  125. Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients
  126. Correlation between microvessel maturity and ISUP grades assessed using contrast-enhanced transrectal ultrasonography in prostate cancer
  127. The protective effect of caffeic acid phenethyl ester in the nephrotoxicity induced by α-cypermethrin
  128. Norepinephrine alleviates cyclosporin A-induced nephrotoxicity by enhancing the expression of SFRP1
  129. Effect of RUNX1/FOXP3 axis on apoptosis of T and B lymphocytes and immunosuppression in sepsis
  130. The function of Foxp1 represses β-adrenergic receptor transcription in the occurrence and development of bladder cancer through STAT3 activity
  131. Risk model and validation of carbapenem-resistant Klebsiella pneumoniae infection in patients with cerebrovascular disease in the ICU
  132. Calycosin protects against chronic prostatitis in rats via inhibition of the p38MAPK/NF-κB pathway
  133. Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia
  134. The safety and immunogenicity to inactivated COVID-19 vaccine in patients with hyperlipemia
  135. Circ-UBR4 regulates the proliferation, migration, inflammation, and apoptosis in ox-LDL-induced vascular smooth muscle cells via miR-515-5p/IGF2 axis
  136. Clinical characteristics of current COVID-19 rehabilitation outpatients in China
  137. Luteolin alleviates ulcerative colitis in rats via regulating immune response, oxidative stress, and metabolic profiling
  138. miR-199a-5p inhibits aortic valve calcification by targeting ATF6 and GRP78 in valve interstitial cells
  139. The application of iliac fascia space block combined with esketamine intravenous general anesthesia in PFNA surgery of the elderly: A prospective, single-center, controlled trial
  140. Elevated blood acetoacetate levels reduce major adverse cardiac and cerebrovascular events risk in acute myocardial infarction
  141. The effects of progesterone on the healing of obstetric anal sphincter damage in female rats
  142. Identification of cuproptosis-related genes for predicting the development of prostate cancer
  143. Lumican silencing ameliorates β-glycerophosphate-mediated vascular smooth muscle cell calcification by attenuating the inhibition of APOB on KIF2C activity
  144. Targeting PTBP1 blocks glutamine metabolism to improve the cisplatin sensitivity of hepatocarcinoma cells through modulating the mRNA stability of glutaminase
  145. A single center prospective study: Influences of different hip flexion angles on the measurement of lumbar spine bone mineral density by dual energy X-ray absorptiometry
  146. Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis
  147. Antibiotics therapy combined with probiotics administered intravaginally for the treatment of bacterial vaginosis: A systematic review and meta-analysis
  148. Construction of a ceRNA network to reveal a vascular invasion associated prognostic model in hepatocellular carcinoma
  149. A pan-cancer analysis of STAT3 expression and genetic alterations in human tumors
  150. A prognostic signature based on seven T-cell-related cell clustering genes in bladder urothelial carcinoma
  151. Pepsin concentration in oral lavage fluid of rabbit reflux model constructed by dilating the lower esophageal sphincter
  152. The antihypertensive felodipine shows synergistic activity with immune checkpoint blockade and inhibits tumor growth via NFAT1 in LUSC
  153. Tanshinone IIA attenuates valvular interstitial cells’ calcification induced by oxidized low density lipoprotein via reducing endoplasmic reticulum stress
  154. AS-IV enhances the antitumor effects of propofol in NSCLC cells by inhibiting autophagy
  155. Establishment of two oxaliplatin-resistant gallbladder cancer cell lines and comprehensive analysis of dysregulated genes
  156. Trial protocol: Feasibility of neuromodulation with connectivity-guided intermittent theta-burst stimulation for improving cognition in multiple sclerosis
  157. LncRNA LINC00592 mediates the promoter methylation of WIF1 to promote the development of bladder cancer
  158. Factors associated with gastrointestinal dysmotility in critically ill patients
  159. Mechanisms by which spinal cord stimulation intervenes in atrial fibrillation: The involvement of the endothelin-1 and nerve growth factor/p75NTR pathways
  160. Analysis of two-gene signatures and related drugs in small-cell lung cancer by bioinformatics
  161. Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1
  162. Menstrual irregularities associated with COVID-19 vaccines among women in Saudi Arabia: A survey during 2022
  163. Ferroptosis involves in Schwann cell death in diabetic peripheral neuropathy
  164. The effect of AQP4 on tau protein aggregation in neurodegeneration and persistent neuroinflammation after cerebral microinfarcts
  165. Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin resistance
  166. Analysis of clinical characteristics in proximal and distal reflux monitoring among patients with gastroesophageal reflux disease
  167. Exosomal circ-0020887 and circ-0009590 as novel biomarkers for the diagnosis and prediction of short-term adverse cardiovascular outcomes in STEMI patients
  168. Upregulated microRNA-429 confers endometrial stromal cell dysfunction by targeting HIF1AN and regulating the HIF1A/VEGF pathway
  169. Bibliometrics and knowledge map analysis of ultrasound-guided regional anesthesia
  170. Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways
  171. D-dimer trends predict COVID-19 patient’s prognosis: A retrospective chart review study
  172. WTAP affects intracranial aneurysm progression by regulating m6A methylation modification
  173. Using of endoscopic polypectomy in patients with diagnosed malignant colorectal polyp – The cross-sectional clinical study
  174. Anti-S100A4 antibody administration alleviates bronchial epithelial–mesenchymal transition in asthmatic mice
  175. Prognostic evaluation of system immune-inflammatory index and prognostic nutritional index in double expressor diffuse large B-cell lymphoma
  176. Prevalence and antibiogram of bacteria causing urinary tract infection among patients with chronic kidney disease
  177. Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?
  178. Identification of disulfidptosis-related genes and immune infiltration in lower-grade glioma
  179. A new technique for uterine-preserving pelvic organ prolapse surgery: Laparoscopic rectus abdominis hysteropexy for uterine prolapse by comparing with traditional techniques
  180. Self-isolation of an Italian long-term care facility during COVID-19 pandemic: A comparison study on care-related infectious episodes
  181. A comparative study on the overlapping effects of clinically applicable therapeutic interventions in patients with central nervous system damage
  182. Low intensity extracorporeal shockwave therapy for chronic pelvic pain syndrome: Long-term follow-up
  183. The diagnostic accuracy of touch imprint cytology for sentinel lymph node metastases of breast cancer: An up-to-date meta-analysis of 4,073 patients
  184. Mortality associated with Sjögren’s syndrome in the United States in the 1999–2020 period: A multiple cause-of-death study
  185. CircMMP11 as a prognostic biomarker mediates miR-361-3p/HMGB1 axis to accelerate malignant progression of hepatocellular carcinoma
  186. Analysis of the clinical characteristics and prognosis of adult de novo acute myeloid leukemia (none APL) with PTPN11 mutations
  187. KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
  188. Evaluation of placental oxygenation by near-infrared spectroscopy in relation to ultrasound maturation grade in physiological term pregnancies
  189. The role of ultrasonographic findings for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2-negative breast cancer
  190. Construction of immunogenic cell death-related molecular subtypes and prognostic signature in colorectal cancer
  191. Long-term prognostic value of high-sensitivity cardiac troponin-I in patients with idiopathic dilated cardiomyopathy
  192. Establishing a novel Fanconi anemia signaling pathway-associated prognostic model and tumor clustering for pediatric acute myeloid leukemia patients
  193. Integrative bioinformatics analysis reveals STAT2 as a novel biomarker of inflammation-related cardiac dysfunction in atrial fibrillation
  194. Adipose-derived stem cells repair radiation-induced chronic lung injury via inhibiting TGF-β1/Smad 3 signaling pathway
  195. Real-world practice of idiopathic pulmonary fibrosis: Results from a 2000–2016 cohort
  196. lncRNA LENGA sponges miR-378 to promote myocardial fibrosis in atrial fibrillation
  197. Diagnostic value of urinary Tamm-Horsfall protein and 24 h urine osmolality for recurrent calcium oxalate stones of the upper urinary tract: Cross-sectional study
  198. The value of color Doppler ultrasonography combined with serum tumor markers in differential diagnosis of gastric stromal tumor and gastric cancer
  199. The spike protein of SARS-CoV-2 induces inflammation and EMT of lung epithelial cells and fibroblasts through the upregulation of GADD45A
  200. Mycophenolate mofetil versus cyclophosphamide plus in patients with connective tissue disease-associated interstitial lung disease: Efficacy and safety analysis
  201. MiR-1278 targets CALD1 and suppresses the progression of gastric cancer via the MAPK pathway
  202. Metabolomic analysis of serum short-chain fatty acid concentrations in a mouse of MPTP-induced Parkinson’s disease after dietary supplementation with branched-chain amino acids
  203. Cimifugin inhibits adipogenesis and TNF-α-induced insulin resistance in 3T3-L1 cells
  204. Predictors of gastrointestinal complaints in patients on metformin therapy
  205. Prescribing patterns in patients with chronic obstructive pulmonary disease and atrial fibrillation
  206. A retrospective analysis of the effect of latent tuberculosis infection on clinical pregnancy outcomes of in vitro fertilization–fresh embryo transferred in infertile women
  207. Appropriateness and clinical outcomes of short sustained low-efficiency dialysis: A national experience
  208. miR-29 regulates metabolism by inhibiting JNK-1 expression in non-obese patients with type 2 diabetes mellitus and NAFLD
  209. Clinical features and management of lymphoepithelial cyst
  210. Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia
  211. ENPP1 ameliorates vascular calcification via inhibiting the osteogenic transformation of VSMCs and generating PPi
  212. Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes
  213. The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study
  214. Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units
  215. Identification of diagnostic immune-related gene biomarkers for predicting heart failure after acute myocardial infarction
  216. Long-term administration of probiotics prevents gastrointestinal mucosal barrier dysfunction in septic mice partly by upregulating the 5-HT degradation pathway
  217. miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor
  218. Diagnostic and prognostic value of MR-pro ADM, procalcitonin, and copeptin in sepsis
  219. Review Articles
  220. Prenatal diagnosis of fetal defects and its implications on the delivery mode
  221. Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis
  222. Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
  223. Saddle pulmonary embolism in the setting of COVID-19 infection: A systematic review of case reports and case series
  224. Vitamin C and epigenetics: A short physiological overview
  225. Ebselen: A promising therapy protecting cardiomyocytes from excess iron in iron-overloaded thalassemia patients
  226. Aspirin versus LMWH for VTE prophylaxis after orthopedic surgery
  227. Mechanism of rhubarb in the treatment of hyperlipidemia: A recent review
  228. Surgical management and outcomes of traumatic global brachial plexus injury: A concise review and our center approach
  229. The progress of autoimmune hepatitis research and future challenges
  230. METTL16 in human diseases: What should we do next?
  231. New insights into the prevention of ureteral stents encrustation
  232. VISTA as a prospective immune checkpoint in gynecological malignant tumors: A review of the literature
  233. Case Reports
  234. Mycobacterium xenopi infection of the kidney and lymph nodes: A case report
  235. Genetic mutation of SLC6A20 (c.1072T > C) in a family with nephrolithiasis: A case report
  236. Chronic hepatitis B complicated with secondary hemochromatosis was cured clinically: A case report
  237. Liver abscess complicated with multiple organ invasive infection caused by hematogenous disseminated hypervirulent Klebsiella pneumoniae: A case report
  238. Urokinase-based lock solutions for catheter salvage: A case of an upcoming kidney transplant recipient
  239. Two case reports of maturity-onset diabetes of the young type 3 caused by the hepatocyte nuclear factor 1α gene mutation
  240. Immune checkpoint inhibitor-related pancreatitis: What is known and what is not
  241. Does total hip arthroplasty result in intercostal nerve injury? A case report and literature review
  242. Clinicopathological characteristics and diagnosis of hepatic sinusoidal obstruction syndrome caused by Tusanqi – Case report and literature review
  243. Synchronous triple primary gastrointestinal malignant tumors treated with laparoscopic surgery: A case report
  244. CT-guided percutaneous microwave ablation combined with bone cement injection for the treatment of transverse metastases: A case report
  245. Malignant hyperthermia: Report on a successful rescue of a case with the highest temperature of 44.2°C
  246. Anesthetic management of fetal pulmonary valvuloplasty: A case report
  247. Rapid Communication
  248. Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
  249. Erratum
  250. Erratum to “Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway”
  251. Erratum to: “Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p”
  252. Retraction
  253. Retraction of “Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients”
  254. Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
  255. Retraction of “miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells”
  256. Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”
  257. Retraction of “circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury”
  258. Retraction of “lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells”
  259. Special issue Linking Pathobiological Mechanisms to Clinical Application for cardiovascular diseases
  260. Effect of cardiac rehabilitation therapy on depressed patients with cardiac insufficiency after cardiac surgery
  261. Special issue The evolving saga of RNAs from bench to bedside - Part I
  262. FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma
  263. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part III
  264. Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer
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