Startseite Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk
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Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk

  • Shouchun Yan , Shouzhen Wu , Jia Wu , Qinlu Zhang , Yongjun He , Chao Jiang EMAIL logo und Tianbo Jin EMAIL logo
Veröffentlicht/Copyright: 9. März 2023
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Open Medicine
Aus der Zeitschrift Open Medicine Band 18 Heft 1

Abstract

Lung cancer is one of the malignant tumors, and genetic background is a risk factor in lung cancer that cannot be neglected. In this study, we aimed to find out the effect of MRPS30-DT and NINJ2 variants on lung cancer risk. In this study, the seven selected single-nucleotide polymorphisms (SNPs) of MRPS30-DT and NINJ2 were genotyped in 509 lung cancer patients and 501 healthy controls based on the Agena MassARRAY platform. Odds ratios and 95% confidence intervals were calculated by logistic regression analysis to evaluate association between gene polymorphisms and lung cancer risk. False-positive report probability was also used to assess false-positive results. Furthermore, the interaction between SNPs was analyzed by multifactor dimensionality reduction to predict lung cancer risk. We identified the genotype TA of rs16901963 (T < A) in MRPS30-DT as a protective factor against lung cancer, while rs16901963-TT was significantly associated with an increased risk of lung cancer. We also revealed that the effect of MRPS30-DT and NINJ2 variants on the risk of lung cancer was dependent on age, gender, smoking, and drinking status. In conclusion, this study first proved that MRPS30-DT and NINJ2 variants played important roles in affecting the susceptibility to lung cancer.

Keywords: MRPS30-DT; NINJ2; lung cancer; single-nucleotide polymorphisms

1 Introduction

Lung cancer is the most threatening malignancy worldwide, with the number of diagnosed cases increasing every year and the 5-year survival rate reaching 10% [1,2]. Risk factors, including smoking, biomass exposure, radiation, and air pollution, were considered to be significantly associated with an increased incidence of lung cancer [3]. However, studies on 10–25% of non-smoking lung cancer patients have demonstrated that internal gene mutations were correlated with abnormal regulation of lung cancer [4]. A large number of epidemiological studies have confirmed that genetic polymorphisms were key factors in the progression of lung cancer. Recently, genome-wide association studies have also identified various single-nucleotide polymorphisms (SNPs) in lung cancer susceptibility genes [5,6]. The discovery of these susceptibility loci, such as 3q28, 5p15.33, 13q12.12, 22q12.2, and 12q23.1, is a crucial step in revealing the genetic background of lung cancer in a specific population.

MRPS30-DT, also known as BRCAT54, is located on chromosome 5p12. It is a divergent transcript of MRPS30. In one article about breast cancer, Wu et al. [7] observed the overexpression of MRPS30-DT by microarray analysis. The higher the expression, the worse the prognosis of patients. Functional experiments have shown that knockdown of MRPS30-DT significantly inhibited the progression of breast cancer and promoted the apoptosis of breast cancer, indicating that MRPS30-DT may be an oncogene in breast cancer. On the contrary, Yang et al. have observed that overexpression of BRCAT54 significantly promoted the apoptosis of lung cancer cells [8]. Therefore, BRCAT54 may act as a tumor suppressor in non-small-cell lung carcinoma. The above results may be related to the heterogeneity of cancer. Furthermore, the genetic variants of MRPS30 region were found to be correlated with the risk of breast cancer [9,10]. However, the association between MRPS30 variants and lung cancer risk was not found. And the effect of polymorphisms in the divergent transcript (MRPS30-DT) on the risk of lung cancer has never been studied.

NINJ2 is located on chromosome 12p13.33 and encodes a transmembrane protein that mediated cell–cell and cell–extracellular matrix interactions during the development, differentiation, and regeneration of nervous system [11]. NINJ2 was observed to be overexpressed in colorectal cancer cells and can promote human colorectal cancer cell growth [12]. Moreover, its overexpression may accelerate the growth of glioma cells [13]. The effects of NINJ2 gene polymorphisms have been widely studied in stroke-related diseases and neurological disorders [14,15,16,17,18], while never in lung cancer. Choi et al. have applied array comparative genomic hybridization to human emphysema and identified NINJ2 with a higher fold change, thereby suggesting that NINJ2 was a potential gene involved in the pathogenesis of emphysema [19]. Thus, NINJ2 gene alterations may play an important role in lung disease, including lung cancer.

Therefore, we set up this case–control study and genotyped seven SNPs of candidate genes in patients with lung cancer and healthy controls. Our study first examined the potential influence of candidate genes on the risk of lung cancer, which provided a theoretical basis for deep understanding of the genetic background of lung cancer.

2 Materials and methods

2.1 Study population

This study enrolled 1,010 subjects from Shaanxi Cancer Hospital, including 509 lung cancer patients and 501 healthy controls. Lung cancer patients were all histopathologically diagnosed, and patients who underwent radiotherapy were not included in the case group. Patients with a family history of lung cancer, other cancers, other lung diseases, or immune diseases were excluded. During the same period, 501 healthy controls were recruited from the healthcare center and they had no history of cancer or chronic diseases. The information about clinical characteristics (age, gender, smoking and drinking status, etc.) of all subjects was collected from questionnaire.

  1. Ethical approval: This study complied with Helsinki Declaration and was approved by theEthics Committee of the Second Affiliated Hospital of Shaanxi University of Chinese Medicine (201204). All participants were informed of the purpose and procedures of this study and signed the informed content.

2.2 SNP selection and genotyping

The SNPs of candidate were downloaded from the 1000 Genomes Project. Then, Haploview software was used to set parameters (Hardy–Weinberg equilibrium [HWE] > 0.01, minor allele frequency [MAF] > 0.05, call rate > 0.95 and r 2 < 0.80) to screen SNPs. In addition to ineffective and unspecific primers, MRPS30-DT (rs16901963 and rs2118763) and NINJ2 (rs118050317, rs75750647, rs7307242, rs10849390, and rs11610368) were screened out. The amplification primers and extension primers for these SNPs were designed through the Agena online platform, as displayed in Table A1. Genomic DNA of all subjects was isolated and extracted from the whole blood samples using the kit (Xi’an GoldMag Co. Ltd., Xi’an, China), and the spectrophotometer was used for the detection of genomic DNA concentration (NanoDrop2000, Thermo, MA, USA). SNP genotyping and data collection were done with the Agena MassARRAY platform and TYPER 4.0 (Agena Bioscience, CA, USA), respectively.

2.3 Statistical analysis

In this study, genotyping data were collated and processed in Excel, SPSS 18.0, and PLINK software for statistical analysis. T-test and chi-square test were used to analyze the differences in age, gender, and clinical indexes between the two groups, respectively. Chi-square test was utilized to determine whether the allele frequencies of SNPs in the control group conformed to HWE. Furthermore, the logistic regression analysis was introduced to evaluate the association between the genetic polymorphisms of candidate genes and the susceptibility to lung cancer under the allelic and genetic models, with the corresponding values of odds ratios (ORs) and 95% confidence intervals (CIs). After adjustment for age and gender, the corresponding OR and 95% CI were also calculated. False-positive report probability (FPRP) analysis was utilized to determine whether there were false positives in significant results. Besides, we carried out linkage disequilibrium (LD) analysis through Haploview 4.2 and used D′ to represent the LD degree of different loci on the same chromosome. We also conducted the logistic regression analysis to assess the correlation between haplotypes and lung cancer risk based on different stratified analyses. Multifactor dimensionality reduction (MDR) software package was utilized to predict the association between the selected SNPs and lung cancer risk. All p-values <0.05 indicated statistical significance.

3 Results

3.1 Demographic and clinical characteristics of subjects and SNP information

The clinical information of 509 patients with lung cancer (57.99 ± 10.56 years, 75% males and 25% females) and 501 healthy controls (60.29 ± 8.13 years, 71% males and 29% females) is summarized in Table 1. The statistical results showed that there were significant differences in age and smoking status between cases and controls (p < 0.001), while no significant differences in gender (p = 0.243) and drinking status (p = 0.096). In addition, we collected the clinical characteristics of participants, including lymph node metastasis, histological type, and clinical stage.

Table 1

Demographic and clinical characteristics of subjects

Variables Case (n = 509) Control (n = 501) p-Value
Age (mean ± SD, years) 57.99 ± 10.56 60.29 ± 8.13 <0.001 a
 ≤59 266 (52%) 227 (45%)
 >59 243 (48%) 274 (55%)
Gender 0.243b
 Male 383 (75%) 354 (71%)
 Female 126 (25%) 147 (29%)
Smoking status <0.001 b
 Yes 313 (62%) 116 (23%)
 No 141 (28%) 176 (35%)
Alcohol consumption status 0.096b
 Yes 146 (29%) 108 (22%)
 No 271 (53%) 153 (31%)
Lymph node metastasis
 Yes 192 (38%)
 No 114 (23%)
Histological type
 Adenocarcinoma 168 (33%)
 Squamous 164 (32%)
Clinical stage
 I/II 82 (16%)
 III/IV 188 (37%)

SD, standard deviation. a p-value was calculated by t-test. b p-value was calculated by chi-square test. Bold data means significant difference (p < 0.05).

The information about seven selected SNPs is shown in Table 2. The analysis results revealed that allele frequencies of seven SNPs were in line with HWE (p > 0.05). No significant differences in allele frequencies were found between the cases and controls.

Table 2

Information about selected SNPs in MRPS30-DT and NINJ2

Gene SNP Chromosome Position Allele A/B Role MAF HWE p-Value OR (95% CI) p-Value
Case Control
MRPS30-DT rs16901963 5 44783000 T/A Intron 0.437 0.428 0.715 1.04 (0.87–1.24) 0.674
MRPS30-DT rs2118763 5 44787444 T/C Intron 0.059 0.060 0.695 0.98 (0.68–1.42) 0.920
NINJ2 rs118050317 12 634980 C/G Intron 0.108 0.105 0.635 1.03 (0.77–1.37) 0.844
NINJ2 rs75750647 12 638831 A/G Intron 0.344 0.334 0.841 1.04 (0.87–1.25) 0.653
NINJ2 rs7307242 12 641529 A/T Intron 0.126 0.132 0.695 0.95 (0.73–1.23) 0.700
NINJ2 rs10849390 12 646086 G/A Intron 0.359 0.341 0.689 1.08 (0.90–1.30) 0.416
NINJ2 rs11610368 12 662624 A/G Intron 0.116 0.124 0.838 0.93 (0.71–1.21) 0.576

SNP, Single-nucleotide polymorphism; MAF, minor allele frequency; HWE, Hardy–Weinberg Equilibrium; OR, odds ratio; 95% CI, 95% confidence interval.

3.2 Association of MRPS30-DT and NINJ2 polymorphisms with lung cancer risk

To evaluate the association between MRPS30-DT and NINJ2 polymorphisms and lung cancer risk, we performed the logistic regression analysis under different genetic models (co-dominant, dominant, recessive, and additive models) and the results are listed in Table 3. The results suggested that the heterozygote TA of rs16901963 in MRPS30-DT was significantly associated with a reduced risk of lung cancer (OR = 0.67, 95% CI: 0.50–0.89, p = 0.006) in contrast with wide genotype AA. However, the genotype rs16901963-TT was found to be related to an increased risk of lung cancer (OR = 1.55, 95% CI: 1.14–2.12, p = 0.005) under the recessive model. In Table 4, the results of FPRP indicated that rs16901963 was still associated with lung cancer risk (TA vs AA: power = 0.978, FPRP = 0.017, 0.050; TT vs TA-AA: power = 0.945, FPRP = 0.019, 0.055).

Table 3

Association of MRPS30-DT and NINJ2 genetic polymorphisms with lung cancer risk

Gene SNP Model Genotype Case Control OR (95% CI) p -Value
MRPS30-DT rs16901963 Co-dominant TT vs AA 126 89 1.24 (0.88–1.76) 0.218
TA vs AA 193 249 0.67 (0.50–0.89) 0.006
Dominant TT-TA vs AA 319 338 0.82 (0.63–1.07) 0.139
Recessive TT vs TA-AA 126 89 1.55 (1.14–2.12) 0.005
Additive — — — 1.05 (0.89–1.25) 0.544
MRPS30-DT rs2118763 Co-dominant TT vs CC 2 2 0.97 (0.13–7.47) 0.978
TC vs CC 56 56 0.94 (0.63–1.40) 0.754
Dominant TT-TC vs CC 58 58 0.94 (0.64–1.39) 0.755
Recessive TT vs TC-CC 2 2 0.98 (0.13–7.51) 0.983
Additive — — — 0.94 (0.65–1.37) 0.763
NINJ2 rs118050317 Co-dominant CC vs GG 9 4 2.02 (0.61–6.70) 0.248
CG vs GG 91 97 0.90 (0.66–1.25) 0.535
Dominant CC-CG vs GG 100 101 0.95 (0.69–1.30) 0.742
Recessive CC vs CG-GG 9 4 2.06 (0.62–6.82) 0.235
Additive — — — 1.00 (0.75–1.33) 0.992
NINJ2 rs75750647 Co-dominant AA vs GG 70 57 1.22 (0.82–1.82) 0.321
AG vs GG 210 221 0.94 (0.72–1.22) 0.632
Dominant AA-AG vs GG 280 278 1.00 (0.78–1.28) 0.973
Recessive AA vs AG-GG 70 57 1.26 (0.87–1.84) 0.224
Additive — — — 1.05 (0.88–1.26) 0.572
NINJ2 rs7307242 Co-dominant AA vs TT 9 7 1.13 (0.42–3.09) 0.080
AT vs TT 110 118 0.92 (0.68–1.24) 0.595
Dominant AA-AT vs TT 119 125 0.93 (0.70–1.25) 0.650
Recessive AA vs AT-TT 9 7 1.15 (0.42–3.14) 0.780
Additive — — — 0.96 (0.73–1.24) 0.736
NINJ2 rs10849390 Co-dominant GG vs AA 76 59 1.27 (0.86–1.88) 0.231
GA vs AA 208 217 0.93 (0.71–1.21) 0.579
Dominant GG-GA vs AA 284 276 1.00 (0.78–1.29) 0.997
Recessive GG vs GA-AA 76 59 1.32 (0.91–1.91) 0.140
Additive — — — 1.07 (0.89–1.28) 0.466
NINJ2 rs11610368 Co-dominant AA vs GG 7 8 0.84 (0.30–2.38) 0.745
AG vs GG 104 108 0.91 (0.67–1.24) 0.560
Dominant AA-AG vs GG 111 116 0.91 (0.67–1.22) 0.527
Recessive AA vs AG-GG 7 8 0.86 (0.30–2.42) 0.773
Additive — — — 0.91 (0.70–1.20) 0.516

SNP, single-nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval. p-Value was calculated by logistic regression analysis with adjustment for age and gender. Bold data means significant difference (p < 0.05).

Table 4

Results of FPRP analysis for significant findings

Model OR (95% CI) Power Prior probability
0.25 0.1 0.01 0.001 0.0001
rs16901963
 TA vs AA 0.67 (0.50–0.89) 0.978 0.017* 0.050* 0.366 0.853 0.983
 TT vs TA-AA 1.55 (1.14–2.12) 0.945 0.019* 0.055* 0.390 0.866 0.985

*The level of FPRP threshold was set at 0.2 and noteworthy findings are presented.

3.3 Stratified analysis of the effect of MRPS30-DT and NINJ2 variants on lung cancer risk

We further performed the stratified analyses by age, gender, smoking, and alcohol consumption to explore the effect of MRPS30-DT and NINJ2 variants on lung cancer risk (Table 5). According to the gender-stratified analysis, heterozygote TA of MRPS30-DT rs16901963 was associated with lung cancer risk in males (heterozygote: adjusted OR = 0.66, 95% CI: 0.47–0.92, p = 0.013; recessive: adjusted OR = 1.48, 95% CI: 1.04–2.13, p = 0.032).

Table 5

Stratified analysis of the association of MRPS30-DT and NINJ2 polymorphisms with lung cancer risk

SNP Subgroups Allele Homozygote Heterozygote Dominant Recessive Additive
OR (95%CI) p -Value OR (95% CI) p -Value OR (95% CI) p -Value OR (95% CI) p -Value OR (95% CI) p -Value OR (95% CI) p -Value
MRPS30-DT
rs16901963 Age (>59) 1.15 (0.90–1.48) 0.256 1.47 (0.91–2.38) 0.116 0.64 (0.43–0.96) 0.030 0.85 (0.58–1.23) 0.382 1.90 (1.25–2.91) 0.003 1.15 (0.91–1.46) 0.249
Male 1.02 (0.83–1.25) 0.853 1.18 (0.79–1.77) 0.421 0.66 (0.47–0.92) 0.013 0.80 (0.59–1.08) 0.144 1.48 (1.04–2.13) 0.032 1.03 (0.84–1.25) 0.808
Smoking 1.09 (0.80–1.48) 0.578 1.46 (0.76–2.80) 0.255 0.63 (0.39–1.04) 0.069 0.82 (0.51–1.29) 0.385 1.89 (1.06–3.39) 0.032 1.10 (0.82–1.48) 0.517
NINJ2
rs75750647 Age (≤59) 1.31 (1.00–1.72) 0.049 1.95 (1.04–3.65) 0.036 1.14 (0.77–1.68) 0.515 1.28 (0.88–1.84) 0.195 1.84 (1.01–3.34) 0.047 1.30 (0.99–1.71) 0.058
rs10849390 Age (≤59) 1.09 (0.84–1.42) 0.524 1.64 (0.90–2.97) 0.105 0.82 (0.55–1.22) 0.324 0.96 (0.66–1.40) 0.832 1.81 (1.03–3.18) 0.039 1.13 (0.86–1.48) 0.380
rs11610368 Age (>59) 0.67 (0.45–0.99) 0.043 0.32 (0.06–1.58) 0.163 0.73 (0.47–1.14) 0.165 0.69 (0.45–1.06) 0.091 0.34 (0.07–1.68) 0.187 0.69 (0.47–1.02) 0.059
Non-smoking 0.54 (0.32–0.90) 0.018 0.25 (0.03–2.50) 0.239 0.53 (0.28–0.98) 0.042 0.50 (0.27–0.92) 0.025 0.29 (0.03–2.81) 0.283 0.52 (0.30–0.91) 0.021
Non-drinking 0.66 (0.44–1.00) 0.048 0.62 (0.16–2.46) 0.499 0.57 (0.35–0.94) 0.026 0.58 (0.36–0.93) 0.023 0.70 (0.18–2.75) 0.612 0.64 (0.42–0.96) 0.033

SNP, single-nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval. p-Value was calculated by logistic regression analysis with adjustment for age and gender. Bold data means significant difference (p < 0.05).

We also selected the average age of 59 as the critical point for stratified analysis. Among patients aged ≤59 years, rs75750647 of NINJ2 was considered a risk factor for lung cancer in the homozygote (adjusted OR = 1.95, 95% CI: 1.04–3.65, p = 0.036) and recessive (adjusted OR = 1.84, 95% CI: 1.01–3.34, p = 0.047) models, while rs10849390 GG carriers had a 0.81-fold increased risk of lung cancer in the recessive model (95% CI: 1.03–3.18, p = 0.039). In patients over 59 years, rs11610368 A and rs16901963 TA were correlated with a decreased risk of lung cancer (adjusted OR = 0.67, 95% CI: 0.45–0.99, p = 0.043; adjusted OR = 0.64, 95% CI: 0.43–0.96, p = 0.030).

Besides, we conducted smoking- and drinking-stratified analysis to explore the association between MRPS30-DT and NINJ2 polymorphisms and the risk of lung cancer. MRPS30-DT rs16901963 was related to an increased risk of lung cancer in the recessive model (adjusted OR = 1.89, 95% CI: 1.06–3.39, p = 0.032) in smokers. However, in non-smoking and non-drinking patients, rs11610368 of NINJ2 was found to be significantly correlated with a reduced susceptibility to lung cancer under the allelic (p = 0.018 and p = 0.048, respectively), heterozygote (p = 0.042 and p = 0.026, respectively), dominant (p = 0.025 and p = 0.023, respectively), and additive (p = 0.021 and p = 0.033, respectively) models.

3.4 LD and haplotype analysis

In the results of LD analysis, we did not find linkage between MRPS30-DT (rs16901963 and rs2118763) and NINJ2 (rs118050317, rs75750647, rs7307242, rs10849390, and rs11610368). No haplotype was found to be associated with the risk of lung cancer (Table 6).

Table 6

Haplotype analysis of the association between MRPS30-DT and NINJ2 polymorphisms and lung cancer risk

Gene SNP Haplotype Fre-case Fre-control p a OR (95% CI) p b
MRPS30-DT rs16901963|rs2118763 AT 0.059 0.060 0.902 0.94 (0.65–1.37) 0.747
TC 0.437 0.428 0.670 1.05 (0.89–1.25) 0.540
AC 0.496 0.488 0.716 1.04 (0.88–1.24) 0.639
NINJ2 rs75750647|rs7307242 GA 0.345 0.334 0.607 1.06 (0.88–1.27) 0.537
CG 0.107 0.104 0.843 1.00 (0.75–1.33) 0.989
GG 0.453 0.439 0.540 1.05 (0.89–1.25) 0.553
NINJ2 rs10849390|rs11610368 GA 0.115 0.119 0.737 0.93 (0.70–1.23) 0.621
GG 0.244 0.220 0.213 1.14 (0.93–1.40) 0.206
AG 0.362 0.344 0.410 1.07 (0.90–1.29) 0.444

SNP, single-nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval; Fre, frequency. a p-value was calculated by chi-square test. b p-value was calculated by logistic regression analysis with adjustment for age and gender. p < 0.05 indicates statistical significance.

3.5 SNP–SNP interactions and lung cancer risk.

In Table 7, MDR analysis showed that the model consisting of four loci (rs16901963, rs2118763, rs7307242, and rs11610368) was considered the best model, with the training accuracy of 56.5%, the testing accuracy of 55.7%, and the cross-validation consistency of 10/10. In Figure 1, the dendrogram (left) and the circle graph (right) indicated that rs16901963 and rs75750647 might play a synergistic role in predicting lung cancer risk.

Table 7

MDR analysis of SNP–SNP interactions of MRPS30-DT and NINJ2 variants

Model Training Bal. Acc. Testing Bal. Acc. CVC OR (95% CI) p-Value
rs16901963 0.547 0.530 10/10 1.52 (1.12–2.07) 0.007
rs16901963, rs2118763 0.556 0.537 10/10 1.65 (1.29–2.12) <0.000
rs16901963, rs75750647, rs7307242 0.562 0.540 10/10 2.18 (1.62–2.96) <0.000
rs16901963, rs2118763, rs7307242, rs11610368 0.565 0.557 10/10 2.11 (1.58–2.83) <0.000
rs16901963, rs118050317, rs75750647, rs10849390, rs11610368 0.551 0.525 10/10 3.15 (2.08–4.77) <0.000
rs16901963, rs2118763, rs118050317, rs75750647, rs10849390, rs11610368 0.558 0.531 10/10 3.77 (2.38–5.95) <0.000
rs16901963, rs2118763, rs118050317, rs75750647, rs7307242, rs10849390, rs11610368 0.545 0.519 10/10 4.39 (2.54–7.59) <0.000

MDR: multi-factor dimensionality reduction; Bal. Acc.: balanced accuracy; CVC: cross-validation consistency; OR: odds ratio; 95% CI: 95% confidence interval. Bold data means significant difference (p < 0.05).

Figure 1 Potential SNP–SNP interactions for predicting the risk of lung cancer risk by MDR analysis.
Figure 1

Potential SNP–SNP interactions for predicting the risk of lung cancer risk by MDR analysis.

4 Discussion

In the present study, we found that MRPS30-DT rs16901963 was related to lung cancer risk in people aged >59 years, males, and smokers. NINJ2 (rs75750647 and rs10849390) increased the risk of lung cancer in people aged ≤59 years, while NINJ2 rs11610368 was correlated with a reduced risk of lung cancer in people aged >59 years, non-drinkers, and non-smokers. The above results will provide a theoretical basis for elucidating the pathogenesis of lung cancer.

Recently, one research reported by Wu et al. has shown that MRPS30-DT was overexpressed in breast cancer through microarray analysis and MRPS30-DT knockdown could significantly inhibit the proliferation and invasion of breast cancer cells [7]. Meanwhile, Yang et al. have put forward that BRCAT54, also known as MRPS30-DT, could inhibit the proliferation of non-small-cell lung cancer [8]. Thus, MRPS30-DT played an important role in the development of cancers. To better study the specific mechanism of MRPS30-DT in specific diseases, researchers have recently adopted a case–control strategy to further explore the possible role of MRPS30-DT polymorphisms in disease progression. At present, Chen et al. have found the contribution of the MRPS30-DT genetic polymorphisms to IgA nephropathy in the Chinese Han population [20]. However, the contribution of the MRPS30-DT genetic polymorphisms to lung cancer has not been discovered in the Chinese Han population. We are the first to report the relationship between MRPS30-DT rs16901963 and lung cancer risk in the Han population in people aged >59 years, males, and smokers. The results still need to be confirmed by subsequent experiments.

NINJ2 has also been observed by Li et al. and Zhou et al. to play a carcinogenic role in colorectal cancer and glioma [12,13]. Cheng et al. have investigated the relationship between NINJ2 variants (rs118050317, rs75750647, rs7307242, rs10849390, and rs11610368) and endometrial cancer susceptibility [21], showing that the rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. In this case–control study, the relationship between rs118050317 and the risk of lung cancer was not found. Nevertheless, NINJ2 (rs75750647 and rs10849390) increased the risk of lung cancer in people aged ≤59 years, while NINJ2 rs11610368 was correlated with a reduced risk of lung cancer in people aged >59 years. Although this relationship was not found in drinkers and smokers, it would still be of great significance to explore the contribution of smoking and alcohol consumption to this correlation. Admittedly, this study has certain limitations. First of all, study subjects were all Han Chinese, and thus, it is necessary to validate our results in different ethnic populations in later studies. In addition, the influence of gene–environment interactions on lung cancer was less investigated due to the insufficient information about participants. Third, the sample size in this study was not large enough to stratify all subtypes of lung cancer. In the following studies, a larger sample size is needed to verify the current results, and related experiments will be conducted to explore the underlying molecular mechanisms of MRPS30-DT and NINJ2 in the regulation of lung cancer.

5 Conclusion

To conclude, we observed the relationship between genetic polymorphisms of MRPS30-DT and NINJ2 and the risk of lung cancer and proved that the effect of variants on lung cancer susceptibility was dependent on age, gender, smoking, and drinking status. Our findings provided a theoretical support for revealing the mechanisms of lung cancer.

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Acknowledgments

We thank all those who contributed to this article.

  1. Funding information: The project was supported by Doctoral Research Start-up Fund Project of Shaanxi University of Chinese Medicine (303-17102032046) and National Natural Science Foundation of China (81860600).

  2. Author contributions: SCY and SZW completed genotyping and performed the manuscript; JW and QLZ participated in the data management, statistical analysis. SCY and YJH revised the manuscript. CJ collected samples. CJ and TBJ designed the study, co-supervised the research and modified the manuscript. All authors have approved the final manuscript.

  3. Conflict of interest: All authors declared no conflict of interest.

  4. Data availability statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on a reasonable request.

Appendix

Table A1

Information about primers in this study

SNP 1st-PCRP (5'-3') 2nd-PCRP (5′−3′) UEP_DIR UEP (5′−3′)
rs16901963 ACGTTGGATGACACTGGATTCACACACTGC ACGTTGGATGTTGAGGACCGCAAAGCATAG R TGTAAATACCATTTCATGAAAAG
rs2118763 ACGTTGGATGCAGTATGCTAATGTAAAGGTG ACGTTGGATGAGCCCAAAGAAAGCCAATTT F ccccTATGTGACAATGTTTCCTTTA
rs118050317 ACGTTGGATGACAGGAGCTGGTCATGTTGC ACGTTGGATGGTGTAGTGATTGACACCTG R ggggtGCCGATGGGGAAGGATTAG
rs75750647 ACGTTGGATGCCCCCACAAAATTACAAACC ACGTTGGATGTGTTCGCTGTGTACTGGATG R CTAAAGCAGGGTGGAG
rs7307242 ACGTTGGATGGCCCTAGCCTGTTTCTTTAG ACGTTGGATGAAATGCTTCTCCTGGAAGTC F CCAGATCACTAGCTCTGA
rs10849390 ACGTTGGATGGAAATCAGTACTGCCTGTGC ACGTTGGATGTCACACAATCTCACAGGGAC F tcgccCAGGGACAGCCCGCTGCC
rs11610368 ACGTTGGATGCTCTGCAATGTTACACAGCC ACGTTGGATGTCTGTGACTCCTTGCCAATG R CCTTGCCAATGGATAGAATAGAA

SNP, single nucleotide polymorphism; PCRP, polymerase chain reaction primer; UEP_DIR, unique base extension primer direction; F, forward; R, reverse; UEP, unique base extension primer.

References

[1] Yan S, Sun R, Wu S, Jin T, Zhang S, Niu F, et al. Single nucleotide polymorphism in the 3’ untranslated region of LPP is a risk factor for lung cancer: a case-control study. BMC Cancer. 2019;19(1):35.10.1186/s12885-018-5241-5Suche in Google Scholar PubMed PubMed Central

[2] Bade BC, Dela Cruz CS. Lung Cancer 2020: Epidemiology, etiology, and prevention. Clin Chest Med. 2020;41(1):1–24.10.1016/j.ccm.2019.10.001Suche in Google Scholar PubMed

[3] Malhotra J, Malvezzi M, Negri E, La Vecchia C, Boffetta P. Risk factors for lung cancer worldwide. Eur Respir J. 2016;48(3):889–902.10.1183/13993003.00359-2016Suche in Google Scholar PubMed

[4] Zhuo M, Zhuang X, Tang W, Xu J, Zhang C, Qian X, et al. The impact of IL-16 3’UTR polymorphism rs859 on lung carcinoma susceptibility among Chinese Han individuals. Biomed Res Int. 2018;2018:8305745.10.1155/2018/8305745Suche in Google Scholar PubMed PubMed Central

[5] Zhang J, Zhao T, Xu C, Huang J, Yu H. Genetic susceptibility of lung cancer in Chinese population: An overview of systematic reviews and meta-analyses. J Evid Based Med. 2017;10(3):207–11.10.1111/jebm.12269Suche in Google Scholar PubMed

[6] Bossé Y, Amos CI. A decade of GWAS results in lung cancer. Cancer Epidemiol Biomarkers Prev. 2018;27(4):363–79.10.1158/1055-9965.EPI-16-0794Suche in Google Scholar PubMed PubMed Central

[7] Wu B, Pan Y, Liu G, Yang T, Jin Y, Zhou F, et al. MRPS30-DT knockdown inhibits breast cancer progression by targeting Jab1/Cops5. Front Oncol. 2019;9:1170.10.3389/fonc.2019.01170Suche in Google Scholar PubMed PubMed Central

[8] Yang W, Qian Y, Gao K, Zheng W, Wu G, He Q, et al. LncRNA BRCAT54 inhibits the tumorigenesis of non-small cell lung cancer by binding to RPS9 to transcriptionally regulate JAK-STAT and calcium pathway genes. Carcinogenesis. 2021;42(1):80–92.10.1093/carcin/bgaa051Suche in Google Scholar PubMed

[9] Huang Y, Ballinger DG, Dai JY, Peters U, Hinds DA, Cox DR, et al. Genetic variants in the MRPS30 region and postmenopausal breast cancer risk. Genome Med. 2012;4(3):19.10.1186/gm318Suche in Google Scholar PubMed PubMed Central

[10] Ghoussaini M, French JD, Michailidou K, Nord S, Beesley J, Canisus S, et al. Evidence that the 5p12 Variant rs10941679 confers susceptibility to estrogen-receptor-positive breast cancer through FGF10 and MRPS30 regulation. Am J Hum Genet. 2016;99(4):903–11.10.1016/j.ajhg.2016.07.017Suche in Google Scholar PubMed PubMed Central

[11] Sayad A, Ghafouri-Fard S, Omrani MD, Taheri M. Associations between two single-nucleotide polymorphisms in NINJ2 gene and risk of psychiatric disorders. J Mol Neurosci. 2020;70(2):236–45.10.1007/s12031-019-01462-1Suche in Google Scholar PubMed

[12] Li G, Zhou LN, Yang H, He X, Duan Y, Wu F. Ninjurin 2 overexpression promotes human colorectal cancer cell growth in vitro and in vivo. Aging. 2019;11(19):8526–41.10.18632/aging.102336Suche in Google Scholar PubMed PubMed Central

[13] Zhou LN, Li P, Cai S, Li G, Liu F. Ninjurin2 overexpression promotes glioma cell growth. Aging. 2019;11(23):11136–47.10.18632/aging.102515Suche in Google Scholar PubMed PubMed Central

[14] Wan XH, Li SJ, Cheng P, Zhang Q, Yang XC, Zhong GZ, et al. NINJ2 polymorphism is associated with ischemic stroke in Chinese Han population. J Neurol Sci. 2011;308(1-2):67–71.10.1016/j.jns.2011.06.011Suche in Google Scholar PubMed

[15] Bis JC, DeStefano A, Liu X, Brody JA, Choi SH, Verhaaren BF, et al. Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium. PLoS One. 2014;9(6):e99798.10.1371/journal.pone.0099798Suche in Google Scholar PubMed PubMed Central

[16] Kim DE, Noh SM, Jeong SW, Cha MH. NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions. BMC Res Notes. 2012;5:155.10.1186/1756-0500-5-155Suche in Google Scholar PubMed PubMed Central

[17] Li W, Hu B, Li GL, Zhao XQ, Xin BZ, Lin JX, et al. Heterozygote genotypes at rs2222823 and rs2811712 SNP loci are associated with cerebral small vessel disease in Han Chinese population. CNS Neurosci Ther. 2012;18(7):558–65.10.1111/j.1755-5949.2012.00322.xSuche in Google Scholar PubMed PubMed Central

[18] Lin KP, Chen SY, Lai LC, Huang YL, Chen JH, Chen TF, et al. Genetic polymorphisms of a novel vascular susceptibility gene, Ninjurin2 (NINJ2), are associated with a decreased risk of Alzheimer’s disease. PLoS One. 2011;6(6):e20573.10.1371/journal.pone.0020573Suche in Google Scholar PubMed PubMed Central

[19] Choi JS, Lee WJ, Baik SH, Yoon HK, Lee KH, Kim YH, et al. Array CGH reveals genomic aberrations in human emphysema. Lung. 2009;187(3):165–72.10.1007/s00408-009-9142-xSuche in Google Scholar PubMed

[20] Chen X, Li H, Liu Y, Liu J, Sun Y, Wu J, et al. The contribution of the LOC105371267 and MRPS30-DT genetic polymorphisms to IgA nephropathy in the Chinese Han population. Am J Transl Res. 2021;13(10):11718–27.10.21203/rs.3.rs-92602/v1Suche in Google Scholar

[21] Cheng Y, Yang L, Shi G, Chen P, Li L, Fang H, et al. Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk. Cancer Cell Int. 2021;21(1):1.10.1186/s12935-020-01646-5Suche in Google Scholar PubMed PubMed Central

Received: 2022-02-24
Revised: 2022-10-21
Accepted: 2023-01-10
Published Online: 2023-03-09

© 2023 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  212. Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes
  213. The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study
  214. Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units
  215. Identification of diagnostic immune-related gene biomarkers for predicting heart failure after acute myocardial infarction
  216. Long-term administration of probiotics prevents gastrointestinal mucosal barrier dysfunction in septic mice partly by upregulating the 5-HT degradation pathway
  217. miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor
  218. Diagnostic and prognostic value of MR-pro ADM, procalcitonin, and copeptin in sepsis
  219. Review Articles
  220. Prenatal diagnosis of fetal defects and its implications on the delivery mode
  221. Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis
  222. Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
  223. Saddle pulmonary embolism in the setting of COVID-19 infection: A systematic review of case reports and case series
  224. Vitamin C and epigenetics: A short physiological overview
  225. Ebselen: A promising therapy protecting cardiomyocytes from excess iron in iron-overloaded thalassemia patients
  226. Aspirin versus LMWH for VTE prophylaxis after orthopedic surgery
  227. Mechanism of rhubarb in the treatment of hyperlipidemia: A recent review
  228. Surgical management and outcomes of traumatic global brachial plexus injury: A concise review and our center approach
  229. The progress of autoimmune hepatitis research and future challenges
  230. METTL16 in human diseases: What should we do next?
  231. New insights into the prevention of ureteral stents encrustation
  232. VISTA as a prospective immune checkpoint in gynecological malignant tumors: A review of the literature
  233. Case Reports
  234. Mycobacterium xenopi infection of the kidney and lymph nodes: A case report
  235. Genetic mutation of SLC6A20 (c.1072T > C) in a family with nephrolithiasis: A case report
  236. Chronic hepatitis B complicated with secondary hemochromatosis was cured clinically: A case report
  237. Liver abscess complicated with multiple organ invasive infection caused by hematogenous disseminated hypervirulent Klebsiella pneumoniae: A case report
  238. Urokinase-based lock solutions for catheter salvage: A case of an upcoming kidney transplant recipient
  239. Two case reports of maturity-onset diabetes of the young type 3 caused by the hepatocyte nuclear factor 1α gene mutation
  240. Immune checkpoint inhibitor-related pancreatitis: What is known and what is not
  241. Does total hip arthroplasty result in intercostal nerve injury? A case report and literature review
  242. Clinicopathological characteristics and diagnosis of hepatic sinusoidal obstruction syndrome caused by Tusanqi – Case report and literature review
  243. Synchronous triple primary gastrointestinal malignant tumors treated with laparoscopic surgery: A case report
  244. CT-guided percutaneous microwave ablation combined with bone cement injection for the treatment of transverse metastases: A case report
  245. Malignant hyperthermia: Report on a successful rescue of a case with the highest temperature of 44.2°C
  246. Anesthetic management of fetal pulmonary valvuloplasty: A case report
  247. Rapid Communication
  248. Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
  249. Erratum
  250. Erratum to “Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway”
  251. Erratum to: “Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p”
  252. Retraction
  253. Retraction of “Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients”
  254. Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
  255. Retraction of “miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells”
  256. Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”
  257. Retraction of “circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury”
  258. Retraction of “lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells”
  259. Special issue Linking Pathobiological Mechanisms to Clinical Application for cardiovascular diseases
  260. Effect of cardiac rehabilitation therapy on depressed patients with cardiac insufficiency after cardiac surgery
  261. Special issue The evolving saga of RNAs from bench to bedside - Part I
  262. FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma
  263. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part III
  264. Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer
https://doi.org/10.1515/med-2023-0655
Schlagwörter für diesen Artikel
MRPS30-DT; NINJ2; lung cancer; single-nucleotide polymorphisms
Creative Commons
BY 4.0

Artikel in diesem Heft

  1. Research Articles
  2. Exosomes derived from mesenchymal stem cells overexpressing miR-210 inhibits neuronal inflammation and contribute to neurite outgrowth through modulating microglia polarization
  3. Current situation of acute ST-segment elevation myocardial infarction in a county hospital chest pain center during an epidemic of novel coronavirus pneumonia
  4. circ-IARS depletion inhibits the progression of non-small-cell lung cancer by circ-IARS/miR-1252-5p/HDGF ceRNA pathway
  5. circRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma
  6. WDR79 promotes aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) by the suppression of SIRT4
  7. Up-regulation of collagen type V alpha 2 (COL5A2) promotes malignant phenotypes in gastric cancer cell via inducing epithelial–mesenchymal transition (EMT)
  8. Inhibition of TERC inhibits neural apoptosis and inflammation in spinal cord injury through Akt activation and p-38 inhibition via the miR-34a-5p/XBP-1 axis
  9. 3D-printed polyether-ether-ketone/n-TiO2 composite enhances the cytocompatibility and osteogenic differentiation of MC3T3-E1 cells by downregulating miR-154-5p
  10. Propofol-mediated circ_0000735 downregulation restrains tumor growth by decreasing integrin-β1 expression in non-small cell lung cancer
  11. PVT1/miR-16/CCND1 axis regulates gastric cancer progression
  12. Silencing of circ_002136 sensitizes gastric cancer to paclitaxel by targeting the miR-16-5p/HMGA1 axis
  13. Short-term outcomes after simultaneous gastrectomy plus cholecystectomy in gastric cancer: A pooling up analysis
  14. SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways
  15. Molecular mechanism by which the Notch signaling pathway regulates autophagy in a rat model of pulmonary fibrosis in pigeon breeder’s lung
  16. lncRNA TPT1-AS1 promotes cell migration and invasion in esophageal squamous-cell carcinomas by regulating the miR-26a/HMGA1 axis
  17. SIRT1/APE1 promotes the viability of gastric cancer cells by inhibiting p53 to suppress ferroptosis
  18. Glycoprotein non-metastatic melanoma B interacts with epidermal growth factor receptor to regulate neural stem cell survival and differentiation
  19. Treatments for brain metastases from EGFR/ALK-negative/unselected NSCLC: A network meta-analysis
  20. Association of osteoporosis and skeletal muscle loss with serum type I collagen carboxyl-terminal peptide β glypeptide: A cross-sectional study in elder Chinese population
  21. circ_0000376 knockdown suppresses non-small cell lung cancer cell tumor properties by the miR-545-3p/PDPK1 pathway
  22. Delivery in a vertical birth chair supported by freedom of movement during labor: A randomized control trial
  23. UBE2J1 knockdown promotes cell apoptosis in endometrial cancer via regulating PI3K/AKT and MDM2/p53 signaling
  24. Metabolic resuscitation therapy in critically ill patients with sepsis and septic shock: A pilot prospective randomized controlled trial
  25. Lycopene ameliorates locomotor activity and urinary frequency induced by pelvic venous congestion in rats
  26. UHRF1-induced connexin26 methylation is involved in hearing damage triggered by intermittent hypoxia in neonatal rats
  27. LINC00511 promotes melanoma progression by targeting miR-610/NUCB2
  28. Ultra-high-performance liquid chromatography-tandem mass spectrometry analysis of serum metabolomic characteristics in people with different vitamin D levels
  29. Role of Jumonji domain-containing protein D3 and its inhibitor GSK-J4 in Hashimoto’s thyroiditis
  30. circ_0014736 induces GPR4 to regulate the biological behaviors of human placental trophoblast cells through miR-942-5p in preeclampsia
  31. Monitoring of sirolimus in the whole blood samples from pediatric patients with lymphatic anomalies
  32. Effects of osteogenic growth peptide C-terminal pentapeptide and its analogue on bone remodeling in an osteoporosis rat model
  33. A novel autophagy-related long non-coding RNAs signature predicting progression-free interval and I-131 therapy benefits in papillary thyroid carcinoma
  34. WGCNA-based identification of potential targets and pathways in response to treatment in locally advanced breast cancer patients
  35. Radiomics model using preoperative computed tomography angiography images to differentiate new from old emboli of acute lower limb arterial embolism
  36. Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks
  37. Single-arm trial to evaluate the efficacy and safety of baclofen in treatment of intractable hiccup caused by malignant tumor chemotherapy
  38. Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk
  39. Efficacy of immune checkpoint inhibitors in patients with KRAS-mutant advanced non-small cell lung cancer: A retrospective analysis
  40. Pyroptosis-based risk score predicts prognosis and drug sensitivity in lung adenocarcinoma
  41. Upregulation of lncRNA LANCL1-AS1 inhibits the progression of non-small-cell lung cancer via the miR-3680-3p/GMFG axis
  42. CircRANBP17 modulated KDM1A to regulate neuroblastoma progression by sponging miR-27b-3p
  43. Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS9
  44. Downregulation of RBM17 enhances cisplatin sensitivity and inhibits cell invasion in human hypopharyngeal cancer cells
  45. HDAC5-mediated PRAME regulates the proliferation, migration, invasion, and EMT of laryngeal squamous cell carcinoma via the PI3K/AKT/mTOR signaling pathway
  46. The association between sleep duration, quality, and nonalcoholic fatty liver disease: A cross-sectional study
  47. Myostatin silencing inhibits podocyte apoptosis in membranous nephropathy through Smad3/PKA/NOX4 signaling pathway
  48. A novel long noncoding RNA AC125257.1 facilitates colorectal cancer progression by targeting miR-133a-3p/CASC5 axis
  49. Impact of omicron wave and associated control measures in Shanghai on health management and psychosocial well-being of patients with chronic conditions
  50. Clinicopathological characteristics and prognosis of young patients aged ≤45 years old with non-small cell lung cancer
  51. TMT-based comprehensive proteomic profiling identifies serum prognostic signatures of acute myeloid leukemia
  52. The dose limits of teeth protection for patients with nasopharyngeal carcinoma undergoing radiotherapy based on the early oral health-related quality of life
  53. miR-30b-5p targeting GRIN2A inhibits hippocampal damage in epilepsy
  54. Long non-coding RNA AL137789.1 promoted malignant biological behaviors and immune escape of pancreatic carcinoma cells
  55. IRF6 and FGF1 polymorphisms in non-syndromic cleft lip with or without cleft palate in the Polish population
  56. Comprehensive analysis of the role of SFXN family in breast cancer
  57. Efficacy of bronchoscopic intratumoral injection of endostar and cisplatin in lung squamous cell carcinoma patients underwent conventional chemoradiotherapy
  58. Silencing of long noncoding RNA MIAT inhibits the viability and proliferation of breast cancer cells by promoting miR-378a-5p expression
  59. AG1024, an IGF-1 receptor inhibitor, ameliorates renal injury in rats with diabetic nephropathy via the SOCS/JAK2/STAT pathway
  60. Downregulation of KIAA1199 alleviated the activation, proliferation, and migration of hepatic stellate cells by the inhibition of epithelial–mesenchymal transition
  61. Exendin-4 regulates the MAPK and WNT signaling pathways to alleviate the osteogenic inhibition of periodontal ligament stem cells in a high glucose environment
  62. Inhibition of glycolysis represses the growth and alleviates the endoplasmic reticulum stress of breast cancer cells by regulating TMTC3
  63. The function of lncRNA EMX2OS/miR-653-5p and its regulatory mechanism in lung adenocarcinoma
  64. Tectorigenin alleviates the apoptosis and inflammation in spinal cord injury cell model through inhibiting insulin-like growth factor-binding protein 6
  65. Ultrasound examination supporting CT or MRI in the evaluation of cervical lymphadenopathy in patients with irradiation-treated head and neck cancer
  66. F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway
  67. Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis
  68. Long noncoding RNA Mhrt alleviates angiotensin II-induced cardiac hypertrophy phenotypes by mediating the miR-765/Wnt family member 7B pathway
  69. Effect of miR-499-5p/SOX6 axis on atrial fibrosis in rats with atrial fibrillation
  70. Cholesterol induces inflammation and reduces glucose utilization
  71. circ_0004904 regulates the trophoblast cell in preeclampsia via miR-19b-3p/ARRDC3 axis
  72. NECAB3 promotes the migration and invasion of liver cancer cells through HIF-1α/RIT1 signaling pathway
  73. The poor performance of cardiovascular risk scores in identifying patients with idiopathic inflammatory myopathies at high cardiovascular risk
  74. miR-2053 inhibits the growth of ovarian cancer cells by downregulating SOX4
  75. Nucleophosmin 1 associating with engulfment and cell motility protein 1 regulates hepatocellular carcinoma cell chemotaxis and metastasis
  76. α-Hederin regulates macrophage polarization to relieve sepsis-induced lung and liver injuries in mice
  77. Changes of microbiota level in urinary tract infections: A meta-analysis
  78. Identification of key enzalutamide-resistance-related genes in castration-resistant prostate cancer and verification of RAD51 functions
  79. Falls during oxaliplatin-based chemotherapy for gastrointestinal malignancies – (lessons learned from) a prospective study
  80. Outcomes of low-risk birth care during the Covid-19 pandemic: A cohort study from a tertiary care center in Lithuania
  81. Vitamin D protects intestines from liver cirrhosis-induced inflammation and oxidative stress by inhibiting the TLR4/MyD88/NF-κB signaling pathway
  82. Integrated transcriptome analysis identifies APPL1/RPS6KB2/GALK1 as immune-related metastasis factors in breast cancer
  83. Genomic analysis of immunogenic cell death-related subtypes for predicting prognosis and immunotherapy outcomes in glioblastoma multiforme
  84. Circular RNA Circ_0038467 promotes the maturation of miRNA-203 to increase lipopolysaccharide-induced apoptosis of chondrocytes
  85. An economic evaluation of fine-needle cytology as the primary diagnostic tool in the diagnosis of lymphadenopathy
  86. Midazolam impedes lung carcinoma cell proliferation and migration via EGFR/MEK/ERK signaling pathway
  87. Network pharmacology combined with molecular docking and experimental validation to reveal the pharmacological mechanism of naringin against renal fibrosis
  88. PTPN12 down-regulated by miR-146b-3p gene affects the malignant progression of laryngeal squamous cell carcinoma
  89. miR-141-3p accelerates ovarian cancer progression and promotes M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway
  90. lncRNA OIP5-AS1 attenuates the osteoarthritis progression in IL-1β-stimulated chondrocytes
  91. Overexpression of LINC00607 inhibits cell growth and aggressiveness by regulating the miR-1289/EFNA5 axis in non-small-cell lung cancer
  92. Subjective well-being in informal caregivers during the COVID-19 pandemic
  93. Nrf2 protects against myocardial ischemia-reperfusion injury in diabetic rats by inhibiting Drp1-mediated mitochondrial fission
  94. Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2B
  95. Bladder cancer screening: The new selection and prediction model
  96. circNFATC3 facilitated the progression of oral squamous cell carcinoma via the miR-520h/LDHA axis
  97. Prone position effect in intensive care patients with SARS-COV-2 pneumonia
  98. Clinical observation on the efficacy of Tongdu Tuina manipulation in the treatment of primary enuresis in children
  99. Dihydroartemisinin ameliorates cerebral I/R injury in rats via regulating VWF and autophagy-mediated SIRT1/FOXO1 pathway
  100. Knockdown of circ_0113656 assuages oxidized low-density lipoprotein-induced vascular smooth muscle cell injury through the miR-188-3p/IGF2 pathway
  101. Low Ang-(1–7) and high des-Arg9 bradykinin serum levels are correlated with cardiovascular risk factors in patients with COVID-19
  102. Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study
  103. Potential protective effects of Huanglian Jiedu Decoction against COVID-19-associated acute kidney injury: A network-based pharmacological and molecular docking study
  104. Clinical significance of serum MBD3 detection in girls with central precocious puberty
  105. Clinical features of varicella-zoster virus caused neurological diseases detected by metagenomic next-generation sequencing
  106. Collagen treatment of complex anorectal fistula: 3 years follow-up
  107. LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through down-regulating SP-A by sponging to miR-424
  108. Efficacy analysis of empirical bismuth quadruple therapy, high-dose dual therapy, and resistance gene-based triple therapy as a first-line Helicobacter pylori eradication regimen – An open-label, randomized trial
  109. SMOC2 plays a role in heart failure via regulating TGF-β1/Smad3 pathway-mediated autophagy
  110. A prospective cohort study of the impact of chronic disease on fall injuries in middle-aged and older adults
  111. circRNA THBS1 silencing inhibits the malignant biological behavior of cervical cancer cells via the regulation of miR-543/HMGB2 axis
  112. hsa_circ_0000285 sponging miR-582-3p promotes neuroblastoma progression by regulating the Wnt/β-catenin signaling pathway
  113. Long non-coding RNA GNAS-AS1 knockdown inhibits proliferation and epithelial–mesenchymal transition of lung adenocarcinoma cells via the microRNA-433-3p/Rab3A axis
  114. lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation
  115. Twenty-four-color full spectrum flow cytometry panel for minimal residual disease detection in acute myeloid leukemia
  116. Hsa-miR-223-3p participates in the process of anthracycline-induced cardiomyocyte damage by regulating NFIA gene
  117. Anti-inflammatory effect of ApoE23 on Salmonella typhimurium-induced sepsis in mice
  118. Analysis of somatic mutations and key driving factors of cervical cancer progression
  119. Hsa_circ_0028007 regulates the progression of nasopharyngeal carcinoma through the miR-1179/SQLE axis
  120. Variations in sexual function after laparoendoscopic single-site hysterectomy in women with benign gynecologic diseases
  121. Effects of pharmacological delay with roxadustat on multi-territory perforator flap survival in rats
  122. Analysis of heroin effects on calcium channels in rat cardiomyocytes based on transcriptomics and metabolomics
  123. Risk factors of recurrent bacterial vaginosis among women of reproductive age: A cross-sectional study
  124. Alkbh5 plays indispensable roles in maintaining self-renewal of hematopoietic stem cells
  125. Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients
  126. Correlation between microvessel maturity and ISUP grades assessed using contrast-enhanced transrectal ultrasonography in prostate cancer
  127. The protective effect of caffeic acid phenethyl ester in the nephrotoxicity induced by α-cypermethrin
  128. Norepinephrine alleviates cyclosporin A-induced nephrotoxicity by enhancing the expression of SFRP1
  129. Effect of RUNX1/FOXP3 axis on apoptosis of T and B lymphocytes and immunosuppression in sepsis
  130. The function of Foxp1 represses β-adrenergic receptor transcription in the occurrence and development of bladder cancer through STAT3 activity
  131. Risk model and validation of carbapenem-resistant Klebsiella pneumoniae infection in patients with cerebrovascular disease in the ICU
  132. Calycosin protects against chronic prostatitis in rats via inhibition of the p38MAPK/NF-κB pathway
  133. Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia
  134. The safety and immunogenicity to inactivated COVID-19 vaccine in patients with hyperlipemia
  135. Circ-UBR4 regulates the proliferation, migration, inflammation, and apoptosis in ox-LDL-induced vascular smooth muscle cells via miR-515-5p/IGF2 axis
  136. Clinical characteristics of current COVID-19 rehabilitation outpatients in China
  137. Luteolin alleviates ulcerative colitis in rats via regulating immune response, oxidative stress, and metabolic profiling
  138. miR-199a-5p inhibits aortic valve calcification by targeting ATF6 and GRP78 in valve interstitial cells
  139. The application of iliac fascia space block combined with esketamine intravenous general anesthesia in PFNA surgery of the elderly: A prospective, single-center, controlled trial
  140. Elevated blood acetoacetate levels reduce major adverse cardiac and cerebrovascular events risk in acute myocardial infarction
  141. The effects of progesterone on the healing of obstetric anal sphincter damage in female rats
  142. Identification of cuproptosis-related genes for predicting the development of prostate cancer
  143. Lumican silencing ameliorates β-glycerophosphate-mediated vascular smooth muscle cell calcification by attenuating the inhibition of APOB on KIF2C activity
  144. Targeting PTBP1 blocks glutamine metabolism to improve the cisplatin sensitivity of hepatocarcinoma cells through modulating the mRNA stability of glutaminase
  145. A single center prospective study: Influences of different hip flexion angles on the measurement of lumbar spine bone mineral density by dual energy X-ray absorptiometry
  146. Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis
  147. Antibiotics therapy combined with probiotics administered intravaginally for the treatment of bacterial vaginosis: A systematic review and meta-analysis
  148. Construction of a ceRNA network to reveal a vascular invasion associated prognostic model in hepatocellular carcinoma
  149. A pan-cancer analysis of STAT3 expression and genetic alterations in human tumors
  150. A prognostic signature based on seven T-cell-related cell clustering genes in bladder urothelial carcinoma
  151. Pepsin concentration in oral lavage fluid of rabbit reflux model constructed by dilating the lower esophageal sphincter
  152. The antihypertensive felodipine shows synergistic activity with immune checkpoint blockade and inhibits tumor growth via NFAT1 in LUSC
  153. Tanshinone IIA attenuates valvular interstitial cells’ calcification induced by oxidized low density lipoprotein via reducing endoplasmic reticulum stress
  154. AS-IV enhances the antitumor effects of propofol in NSCLC cells by inhibiting autophagy
  155. Establishment of two oxaliplatin-resistant gallbladder cancer cell lines and comprehensive analysis of dysregulated genes
  156. Trial protocol: Feasibility of neuromodulation with connectivity-guided intermittent theta-burst stimulation for improving cognition in multiple sclerosis
  157. LncRNA LINC00592 mediates the promoter methylation of WIF1 to promote the development of bladder cancer
  158. Factors associated with gastrointestinal dysmotility in critically ill patients
  159. Mechanisms by which spinal cord stimulation intervenes in atrial fibrillation: The involvement of the endothelin-1 and nerve growth factor/p75NTR pathways
  160. Analysis of two-gene signatures and related drugs in small-cell lung cancer by bioinformatics
  161. Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1
  162. Menstrual irregularities associated with COVID-19 vaccines among women in Saudi Arabia: A survey during 2022
  163. Ferroptosis involves in Schwann cell death in diabetic peripheral neuropathy
  164. The effect of AQP4 on tau protein aggregation in neurodegeneration and persistent neuroinflammation after cerebral microinfarcts
  165. Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin resistance
  166. Analysis of clinical characteristics in proximal and distal reflux monitoring among patients with gastroesophageal reflux disease
  167. Exosomal circ-0020887 and circ-0009590 as novel biomarkers for the diagnosis and prediction of short-term adverse cardiovascular outcomes in STEMI patients
  168. Upregulated microRNA-429 confers endometrial stromal cell dysfunction by targeting HIF1AN and regulating the HIF1A/VEGF pathway
  169. Bibliometrics and knowledge map analysis of ultrasound-guided regional anesthesia
  170. Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways
  171. D-dimer trends predict COVID-19 patient’s prognosis: A retrospective chart review study
  172. WTAP affects intracranial aneurysm progression by regulating m6A methylation modification
  173. Using of endoscopic polypectomy in patients with diagnosed malignant colorectal polyp – The cross-sectional clinical study
  174. Anti-S100A4 antibody administration alleviates bronchial epithelial–mesenchymal transition in asthmatic mice
  175. Prognostic evaluation of system immune-inflammatory index and prognostic nutritional index in double expressor diffuse large B-cell lymphoma
  176. Prevalence and antibiogram of bacteria causing urinary tract infection among patients with chronic kidney disease
  177. Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?
  178. Identification of disulfidptosis-related genes and immune infiltration in lower-grade glioma
  179. A new technique for uterine-preserving pelvic organ prolapse surgery: Laparoscopic rectus abdominis hysteropexy for uterine prolapse by comparing with traditional techniques
  180. Self-isolation of an Italian long-term care facility during COVID-19 pandemic: A comparison study on care-related infectious episodes
  181. A comparative study on the overlapping effects of clinically applicable therapeutic interventions in patients with central nervous system damage
  182. Low intensity extracorporeal shockwave therapy for chronic pelvic pain syndrome: Long-term follow-up
  183. The diagnostic accuracy of touch imprint cytology for sentinel lymph node metastases of breast cancer: An up-to-date meta-analysis of 4,073 patients
  184. Mortality associated with Sjögren’s syndrome in the United States in the 1999–2020 period: A multiple cause-of-death study
  185. CircMMP11 as a prognostic biomarker mediates miR-361-3p/HMGB1 axis to accelerate malignant progression of hepatocellular carcinoma
  186. Analysis of the clinical characteristics and prognosis of adult de novo acute myeloid leukemia (none APL) with PTPN11 mutations
  187. KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
  188. Evaluation of placental oxygenation by near-infrared spectroscopy in relation to ultrasound maturation grade in physiological term pregnancies
  189. The role of ultrasonographic findings for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2-negative breast cancer
  190. Construction of immunogenic cell death-related molecular subtypes and prognostic signature in colorectal cancer
  191. Long-term prognostic value of high-sensitivity cardiac troponin-I in patients with idiopathic dilated cardiomyopathy
  192. Establishing a novel Fanconi anemia signaling pathway-associated prognostic model and tumor clustering for pediatric acute myeloid leukemia patients
  193. Integrative bioinformatics analysis reveals STAT2 as a novel biomarker of inflammation-related cardiac dysfunction in atrial fibrillation
  194. Adipose-derived stem cells repair radiation-induced chronic lung injury via inhibiting TGF-β1/Smad 3 signaling pathway
  195. Real-world practice of idiopathic pulmonary fibrosis: Results from a 2000–2016 cohort
  196. lncRNA LENGA sponges miR-378 to promote myocardial fibrosis in atrial fibrillation
  197. Diagnostic value of urinary Tamm-Horsfall protein and 24 h urine osmolality for recurrent calcium oxalate stones of the upper urinary tract: Cross-sectional study
  198. The value of color Doppler ultrasonography combined with serum tumor markers in differential diagnosis of gastric stromal tumor and gastric cancer
  199. The spike protein of SARS-CoV-2 induces inflammation and EMT of lung epithelial cells and fibroblasts through the upregulation of GADD45A
  200. Mycophenolate mofetil versus cyclophosphamide plus in patients with connective tissue disease-associated interstitial lung disease: Efficacy and safety analysis
  201. MiR-1278 targets CALD1 and suppresses the progression of gastric cancer via the MAPK pathway
  202. Metabolomic analysis of serum short-chain fatty acid concentrations in a mouse of MPTP-induced Parkinson’s disease after dietary supplementation with branched-chain amino acids
  203. Cimifugin inhibits adipogenesis and TNF-α-induced insulin resistance in 3T3-L1 cells
  204. Predictors of gastrointestinal complaints in patients on metformin therapy
  205. Prescribing patterns in patients with chronic obstructive pulmonary disease and atrial fibrillation
  206. A retrospective analysis of the effect of latent tuberculosis infection on clinical pregnancy outcomes of in vitro fertilization–fresh embryo transferred in infertile women
  207. Appropriateness and clinical outcomes of short sustained low-efficiency dialysis: A national experience
  208. miR-29 regulates metabolism by inhibiting JNK-1 expression in non-obese patients with type 2 diabetes mellitus and NAFLD
  209. Clinical features and management of lymphoepithelial cyst
  210. Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia
  211. ENPP1 ameliorates vascular calcification via inhibiting the osteogenic transformation of VSMCs and generating PPi
  212. Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes
  213. The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study
  214. Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units
  215. Identification of diagnostic immune-related gene biomarkers for predicting heart failure after acute myocardial infarction
  216. Long-term administration of probiotics prevents gastrointestinal mucosal barrier dysfunction in septic mice partly by upregulating the 5-HT degradation pathway
  217. miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor
  218. Diagnostic and prognostic value of MR-pro ADM, procalcitonin, and copeptin in sepsis
  219. Review Articles
  220. Prenatal diagnosis of fetal defects and its implications on the delivery mode
  221. Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis
  222. Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
  223. Saddle pulmonary embolism in the setting of COVID-19 infection: A systematic review of case reports and case series
  224. Vitamin C and epigenetics: A short physiological overview
  225. Ebselen: A promising therapy protecting cardiomyocytes from excess iron in iron-overloaded thalassemia patients
  226. Aspirin versus LMWH for VTE prophylaxis after orthopedic surgery
  227. Mechanism of rhubarb in the treatment of hyperlipidemia: A recent review
  228. Surgical management and outcomes of traumatic global brachial plexus injury: A concise review and our center approach
  229. The progress of autoimmune hepatitis research and future challenges
  230. METTL16 in human diseases: What should we do next?
  231. New insights into the prevention of ureteral stents encrustation
  232. VISTA as a prospective immune checkpoint in gynecological malignant tumors: A review of the literature
  233. Case Reports
  234. Mycobacterium xenopi infection of the kidney and lymph nodes: A case report
  235. Genetic mutation of SLC6A20 (c.1072T > C) in a family with nephrolithiasis: A case report
  236. Chronic hepatitis B complicated with secondary hemochromatosis was cured clinically: A case report
  237. Liver abscess complicated with multiple organ invasive infection caused by hematogenous disseminated hypervirulent Klebsiella pneumoniae: A case report
  238. Urokinase-based lock solutions for catheter salvage: A case of an upcoming kidney transplant recipient
  239. Two case reports of maturity-onset diabetes of the young type 3 caused by the hepatocyte nuclear factor 1α gene mutation
  240. Immune checkpoint inhibitor-related pancreatitis: What is known and what is not
  241. Does total hip arthroplasty result in intercostal nerve injury? A case report and literature review
  242. Clinicopathological characteristics and diagnosis of hepatic sinusoidal obstruction syndrome caused by Tusanqi – Case report and literature review
  243. Synchronous triple primary gastrointestinal malignant tumors treated with laparoscopic surgery: A case report
  244. CT-guided percutaneous microwave ablation combined with bone cement injection for the treatment of transverse metastases: A case report
  245. Malignant hyperthermia: Report on a successful rescue of a case with the highest temperature of 44.2°C
  246. Anesthetic management of fetal pulmonary valvuloplasty: A case report
  247. Rapid Communication
  248. Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
  249. Erratum
  250. Erratum to “Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway”
  251. Erratum to: “Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p”
  252. Retraction
  253. Retraction of “Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients”
  254. Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
  255. Retraction of “miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells”
  256. Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”
  257. Retraction of “circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury”
  258. Retraction of “lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells”
  259. Special issue Linking Pathobiological Mechanisms to Clinical Application for cardiovascular diseases
  260. Effect of cardiac rehabilitation therapy on depressed patients with cardiac insufficiency after cardiac surgery
  261. Special issue The evolving saga of RNAs from bench to bedside - Part I
  262. FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma
  263. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part III
  264. Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer
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Heruntergeladen am 17.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/med-2023-0655/html
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