Startseite Vitamin C and epigenetics: A short physiological overview
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Vitamin C and epigenetics: A short physiological overview

  • Voja Pavlovic EMAIL logo , Milan Ciric , Milan Petkovic und Mladjan Golubovic
Veröffentlicht/Copyright: 22. Juni 2023
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Open Medicine
Aus der Zeitschrift Open Medicine Band 18 Heft 1

Abstract

In recent years, ascorbic acid (vitamin C) has acquired great interest due to its multiple functions, which results in homeostasis of normal tissues and organs. On the other hand, it has been shown that epigenetic modifications may have an important role in various diseases and therefore are a focus of the extraordinary investigation. Ascorbic acid serves as a cofactor for ten-eleven translocation dioxygenases, which are responsible for deoxyribonucleic acid methylation. Also, vitamin C is required for histone demethylation, since it acts as a cofactor of Jumonji C-domain-containing histone demethylases. It seems that vitamin C may be a mediator between the environment and the genome. The precise and multistep mechanism of ascorbic acid in epigenetic control is still not definitely determined. This article intends to provide the basic and newly discovered functions of vitamin C that are related to epigenetic control. Also, this article will help us to better understand the functions of ascorbic acid and will provide the possible implications of this vitamin in the regulation of epigenetic modifications.

Keywords: ascorbic acid; epigenetics; DNA methylation; histone modification

1 Introduction

Ascorbic acid, also known as vitamin C or ascorbate, is an essential vitamin that has different key roles in human physiology. All mammals are able to synthesize vitamin C in the liver and provide a steady supply of vitamin C to the body through circulation. However, primates, guinea pigs, and fruit bats have lost this capability due to mutations in the gene encoding l-gulonolactone oxidase enzyme [1]. This enzyme is responsible for catalyzing the conversion of l-gulono-g-lactone into water-soluble ascorbic acid [2]. Consequently, humans must acquire vitamin C from dietary sources to maintain tissue concentration. Low dietary vitamin C intake (with plasma ascorbic acid concentrations <11 µmol/l) results in a vitamin C deficiency disease named “scurvy,” a potentially fatal disease in humans and other animals unable to endogenously produce ascorbic acid [3]. Nowadays, scurvy is very rare but hypovitaminosis of ascorbic acid (with plasma ascorbic acid concentrations <23 µmol/l) is frequent in the adult population [4] and is more dominant among subgroups of the pregnant woman and smokers [5].

Ascorbic acid is an electron donor (possesses an intensive reductive potential); it can be oxidized to the ascorbic radical and then to dehydroascorbic acid. Ascorbic radical is a relatively stable and unreactive molecule [6]. On the other hand, dehydroascorbic acid is an unstable molecule with a short half-life [2], and it is rapidly reduced back to ascorbic acid by glutathione-dependent cellular reducing systems [3]. Both forms of vitamin C (ascorbic and dehydroascorbic acid) are present in the human diet, and their absorption takes place at the level of enterocytes of the small intestine. By entering into the cells, vitamin C displays key roles in many biological processes acting as an electron donor. Micromolar concentrations of vitamin C exert redox function and can reduce dangerous reactive oxygen species (ROS), which are produced during the normal metabolic mitochondrial oxidative metabolism [7]. However, pharmacological or millimolar vitamin C concentrations may act as pro-oxidant and exert a cytotoxic effect against tumor cells compared to normal cells [8]. Besides its antioxidative functions, vitamin C acts as a cofactor for enzymes involved in the process of collagen synthesis [9], functions as a reducing agent for several iron-dependent enzymes, and affects iron metabolism [10]. Among different biological functions of vitamin C, relatively the newly discovered role of vitamin C is that it acts as a cofactor of the ten-eleven translocation (TET) and Jumonji C-domain-containing histone demethylases (JHDM), which belong to the Fe(ii)- and α-ketoglutarate dioxygenase superfamily, which are involved in deoxyribonucleic acid (DNA) methylation and histone modification [7,11].

Given the diverse roles of vitamin C in human physiology, the purpose of this article is to clarify the role of vitamin C in epigenetic regulation, the role of vitamin C in modulating the activity of some enzymes involved in epigenetic reprogramming, and the potential role of vitamin C in the outcome of epigenetic therapy.

2 Basic biological functions of vitamin C

To apply its biological properties, vitamin C must enter into the cells by using specific transporters. Since vitamin C can exist in two different forms (ascorbic acid and dehydroascorbic acid), there are two dissimilar transport mechanisms. Ascorbic acid is co-transported, across the cell membrane, through sodium-dependent vitamin C transporters 1 and 2 (SVCT1 and SVCT2) together with sodium [12]. SVCT1 transporters are mainly expressed at the level of intestinal epithelial and renal tubular cells, and they are responsible for the dietary absorption of ascorbic acid [13]. On the other hand, SVCT2 transporters are widely expressed in various tissues and are responsible for the distribution of ascorbic acid from the bloodstream to target organs [14]. However, the absorption of dehydroascorbic acid from the intestinal lumen occurs primarily by facilitated glucose transporters 2 and 8 (GLUT2 and GLUT8) [15]. Dehydroascorbic acid is able to compete with dietary glucose for uptake into the cells through GLUT1, GLUT3, and GLUT4 [6]. In the cells, dehydroascorbic acid is rapidly reduced to ascorbic acid and stays trapped intracellularly [6]. During physiological conditions, dehydroascorbic acid is present in small amounts, compared to glucose, which results in a minor dehydroascorbic acid uptake via GLUT transporters [15].

In humans, the recommended daily intake of vitamin C is 75–90 mg/day [8] and should be achieved with a diet containing fruits and vegetables. However, for elderly people who are at risk of developing cardiovascular diseases and cancer as well as those with reduced immune function, higher amounts of vitamin C (120 mg/day) have been recommended [16]. Also, vitamin C in human body shows a diverse distribution (Table 1). Plasma concentration of vitamin C is tightly controlled by intestinal uptake and kidney excretion [6]. Additionally, all intracellular vitamin C concentrations are higher than its extracellular concentrations, omitting the erythrocytes that have vitamin C concentrations similar to those in plasma [6]. The highest vitamin C concentrations are found in the brain and adrenal glands [12], while circulating blood cells (neutrophils, lymphocytes, monocytes, and platelets) have vitamin C concentrations ranging between 1 and 4 mM [17].

Table 1

Tissue distribution of vitamin C in some tissues of human body

Tissue Vitamin C concentration (mM)
Heart 0.2–0.4
Adrenal glands 4–10
Kidney 0.3–0.5
Lungs 1
Skeletal muscle 0.2–0.4
Liver 1
Brain 2–10

Vitamin C displays diverse functions in the human body. As an electron donor, it can reduce ROS and therefore protects and maintains protein integrity in cells intracellularly and extracellularly [6] against various mutations [1]. Besides its antioxidative functions, vitamin C influences iron metabolism by stimulating ferritin synthesis and inhibiting ferritin degradation as well as the absorption of ferric iron (Fe(iii)) [10]. Similarly, for the absorption of iron from the intestinal lumen, ferric iron has to be reduced to the ferrous state (Fe(ii)), which occurs in the presence of vitamin C [18]. In addition, vitamin C is an essential cofactor for enzymes (prolyl-3-hydroxylase, prolyl-4-hydroxylase, and lysyl hydroxylase) involved in the hydroxylation of proline and lysine, which elucidates the crucial role of this vitamin in collagen synthesis [9]. Also, ascorbic acid promotes the reduction of iron to the ferrous state and accordingly keeps prolyl hydroxylase active [19]. Reduced amount of vitamin C results in decreased collagen stability and finally results in the development of scurvy [6]. It has been shown that vitamin C stimulates the activity of natural killer cells and cytotoxic T lymphocytes [20]. Furthermore, earlier studies showed that vitamin C inactivated DNA and RNA viruses with attenuated viral activity [21,22]. In line with this, the results of the same studies showed that vitamin C is a vital factor in the production of interferon type I during antiviral response [22] and is present in the respiratory tract where it helps to alleviate symptoms of upper respiratory tract infections [23].

Among the diverse biological functions of vitamin C, a relatively newly discovered role of this vitamin is to act as a modulator of the activity of several (including TET and JHDMs) enzymes, which shows its essential role in epigenetic regulation. Also, a recent report documented the role of vitamin C in regulating the function of embryonic stem cells and hematopoietic stem cells from epigenetic alterations [24], indicating the ability of vitamin C to modulate the epigenome with some potential therapeutic benefits.

3 Vitamin C and DNA methylation

Various reports documented that normal epigenetic regulation is altered during tumorigenesis and disrupted DNA methylation is a hallmark of cancer [25], which leads to genomic instability and malignant transformation [26]. Methylation of DNA cytosines represents epigenetic modification that regulates gene expression, without changing DNA sequence, and simultaneously limits the accessibility of transcription factors to promoters or any other regulatory component [6]. Most of the methylated cytosines are located in heterochromatic regions, making certain that chromatin stays closed and gene silenced when cells do not have the capacity to be actively transcribed [3]. Therefore, under physiological conditions, around 80% of cytosines are methylated in the mammalian genome, in the context of CpG dinucleotides [27]. On the other hand, hypomethylation and hypermethylation are related to genomic instability and carcinogenesis. By hypermethylation of CpG-rich regions (also known as CpG islands) in promoter regions, DNA methylation is able to directly silence gene expression [28]. Since around 70% of human gene promoters have associated CpG islands, this is a crucial mechanism by which DNA methylation controls gene expression [29]. In line with this, DNA hypomethylation can lead to the expression of atypical oncogenes and further tumorigenesis, while DNA hypermethylation may result in a silenced expression of DNA repair genes and reduced DNA repair proteins [30,31]. Therefore, making the balance between writers and erasers of DNA methylation preserves cells from obtaining indefinite changes to the genetic code.

During the process of DNA methylation, DNA methyltransferases (DNMT1, 3A, and 3B) catalyze the addition of methyl group to C5 of cytosine, forming 5-methylcystosine (5mC), which is the key step in the DNA methylation process [32]. Most of the CpG islands are close to gene promoter regions, and they are the most methylated regions in the mammalian genome [29]. Usually, DNMT1 is responsible for the preservation of methylation during DNA replication, while DNMT3A and DNMT3B are essential for de novo synthesis [25]. Furthermore, the methylation of lysine, by histone lysine methyltransferases, is an essential histone modification, and it is demethylated by histone lysine demethylases [33]. Vitamin C acts as a cofactor for TET enzymes (TET1, 2, and 3) that catalyze the oxidation of 5mC to 5-hydroxymethylcytosine (5hmC). Demethylation process continues with the oxidation of 5hmC to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC), which are finally removed and replaced with unmethylated cytosine through the base excision repair mechanism [34]. Embryonic stem cells undergo a stable 5hmC modification, which can vary widely in different cells. At the same time, the presence of 5hmC results in a passive loss of DNA methylation, since DNMT1 is not able to recognize hemimethylated 5hmC [35]. Levels of 5fC and 5caC represent the rare modifications in genome, and their frequency is minor [25].

Vitamin C is responsible for TET activity, as a necessary step during DNA methylation and the concentration of TET enzymes corresponds with DNA methylation status. The involvement of TET1 in the oxidation of 5mC to 5hmC was documented back in 2009 [36], while the roles of TET2 and TET3 in the same process were reported later [37]. Dysregulation of DNA methylation may be the result of several mechanisms, including the reduced activity of TET enzymes, or DNMT, which leads to hypomethylation (loss of oncogene silencing) or hypermethylation (aberrant silencing of different tumor suppressors) (Table 2). These TET enzymes are Fe(ii) and 2-oxoglutarate-dependent dioxygenases. It is well documented that reduced levels of 5hmC are found in different human cancers, indicating a loss of TET activity [38]. Besides a decrease in TET expression and mutational aberrations, decreased levels of 5hmC may be due to inadequate amounts of TET cofactors, including vitamin C and oxygen, which are common in the hypoxic tumor microenvironment [16]. In accordance with previous findings, the addition of vitamin C enhanced DNA demethylation, by increasing TET activity in embryonic stem cells [39] and vitamin C induces widespread DNA demethylation of around 2,000 genes in embryonic stem cells [40]. In addition, TET2 mutations are linked to increased 5mC and reduced 5hmC in patients with myeloid malignancies [41]. A recent study demonstrated that the oral supplementation of vitamin C resulted in an increased 5hmC/5mC ratio compared to placebo-treated patients [42]. In human skin cancer cells, the application of vitamin C, against UV-mediated apoptosis, showed demethylation and reactivation of silenced tumor suppressor genes p21 and p16 in a TET-dependent manner [43]. In vitro study confirms that vitamin C induces an 8-fold increase of hydroxymethylation, while other reducing agents (vitamin E, vitamin B1, NADPH) could not stimulate the TET2 catalytic activity [44]. However, another study reported that some reducing agents are able to stimulate TET activity but without such efficiency as vitamin C [45], highlighting the role of vitamin C in promoting TET activity. Together with vitamin C, oxygen is also necessary for the proper activity of TET enzymes. Previous findings showed that TET activity is reduced by tumor hypoxia in different cells [46]. Hypoxic tumor tissue shows hypermethylation at tumor suppressor gene promoters, suggesting that, besides vitamin C, oxygen is one of the main regulation factors of DNA methylation.

Table 2

Role of TET enzymes in general development

Enzyme General role in development
TET1 Highly expressed in mouse embryonic stem cells where it preserves them in pluripotent stem state; necessary for brain development; lack of this enzyme leads to memory disorder and altered ectoderm development
TET2 Necessary for brain development and hematopoietic development; lack of TET1 leads to exencephaly; loss of this enzyme results in leukemia initiation and other hematopoietic disorders
TET3 Crucial for proper embryonic development, neural and mesoderm cell growth and brain development; loss of this enzyme leads to embryonic lethality intellectual disorders; lack of TET1 enzyme results in holoprosencephaly

Even in the last few years, many research studies have been conducted about the relationship between vitamin C and TET activity. In the context of leukemia research, the precise role of vitamin C in TET catalytic activity still remains unclear. Up to now, there are two different theories that are able to explain the potential relationship between vitamin C and TET activity. The first mechanism includes the possibility that TET enzymes have a specific binding site for vitamin C where it reduces enzyme-bound iron. Another possibility is that vitamin C induces TET activity not through the binding site but rather by converting (Fe(iii)) to (Fe(ii)). Further analysis is required to clarify whether the exact mechanism is responsible for TET activity. Furthermore, the role of vitamin C for optimal TET activity requires adequate amounts of iron in Fe(ii) form for optimal 5hmC production [46]. In line with this, the same report documented that 100-fold less Fe(ii) (instead of Fe(iii)) is sufficient to sustain the full TET activity, while iron activity is mainly dependent on pH [46]. Also, oxygen and α-ketoglutarate are necessary for optimal TET activity [47]. On the other hand, taking into account that vitamin C levels are markedly reduced in pregnant women [5] and cancer patients, they need additional supplementation, especially for the elderly (aged 75 years) [6]. This is in line with previous reports that show a strong correlation between the reduction in vitamin C (decreased absorption and reduced cellular uptake) and the process of aging, showing that vitamin C levels reduced around 50% of leukocytes at the age of 85 [11], which shows that vitamin C may have an influence on the development of neurodegenerative disorders [11]. The earlier report demonstrated that ascorbic acid has a key role in preventing aging in embryonic stem cells in vitro [48]. Similarly, in mesenchymal stem cells, vitamin C increases telomerase activity and gene expression that protect the telomere stability [48]. Moreover, in normal conditions, DHA is rapidly intracellularly converted to ascorbate. However, if this mechanism is overloaded, it may lead to the degradation of vitamin C as the result of the short half-time of DHA [49].

4 Vitamin C and histone modification

Besides DNA methylation, the transfer of a methyl group of residues of histone proteins is also a key epigenetic mark that controls stem cell homeostasis. The addition of methyl group to lysine residues is catalyzed by histone methyltransferases (HMTs) [50]. In DNA methylation, only one methyl group is added to cytosine, but in histone methylation, two or three methyl groups may be added to lysine [51]. Recently, the process of histone methylation was considered to be irreversible. However, the earlier report documented the removal of the methyl group from the methylated histone, indicating that the histone methylation process is reversible [52]. The majority of HMTs are JHDMs, which can catalyze demethylation that requires Fe(ii) and α-ketoglutarate [33]. Until now, around 20 different proteins that belong to the JHDM, with a catalytic activity to demethylate histones, have been discovered [53]. The regulatory roles of these enzymes are dependent on vitamin C for their optimal catalytic activity [54]. This observation was confirmed by various reports, which documented that vitamin C is necessary for regular T-cell maturation [55], neural differentiation of embryonic stem cells [56], hearing and functions [57], and cardiac development [58]. Similar findings were confirmed by using in vitro study where the depletion of vitamin C resulted in almost complete inhibition of histone demethylation [59]. Based on the abovementioned observations, the role of vitamin C in epigenome regulation needs further consideration.

5 Conclusion

Taken together with previous findings, indicating the role of vitamin C for the regular function of TET and JHDM enzymes and the resulting DNA and histone demethylation, the lack of this water-soluble vitamin may probably result in weakness of cellular reprogramming, which may result in neoplastic growth, especially among hematological cancers. Further examinations are necessary to confirm whether vitamin C supplementation may result in increased catalytic activity of epigenetic regulators. Having in mind that atypical epigenetic regulation is very common in almost all cancers, the regulatory effect of vitamin C on the methylation of DNA and histones may have some benefits in some types of neoplastic disorders.

  1. Funding information: The authors state that no funding is involved.

  2. Author contributions: VP conceptualized and designed the study and collected the data. MC analyzed and prepared the results. MP and MG validated the data.

  3. Conflict of interest: All authors declare no support from any organization for the submitted work; no financial relationship with any organization that might have an interest in the submitted work; and no other relationships or activities that might appear to have influenced the submitted work. Dr. Voja Pavlovic serves as an editor in Open Medicine, but this did not affect the peer-review process.

  4. Data availability statement: All data generated or analyzed during this study are included in this published article.

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Received: 2023-01-08
Revised: 2023-02-18
Accepted: 2023-03-10
Published Online: 2023-06-22

© 2023 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Artikel in diesem Heft

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  178. Identification of disulfidptosis-related genes and immune infiltration in lower-grade glioma
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  193. Integrative bioinformatics analysis reveals STAT2 as a novel biomarker of inflammation-related cardiac dysfunction in atrial fibrillation
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  198. The value of color Doppler ultrasonography combined with serum tumor markers in differential diagnosis of gastric stromal tumor and gastric cancer
  199. The spike protein of SARS-CoV-2 induces inflammation and EMT of lung epithelial cells and fibroblasts through the upregulation of GADD45A
  200. Mycophenolate mofetil versus cyclophosphamide plus in patients with connective tissue disease-associated interstitial lung disease: Efficacy and safety analysis
  201. MiR-1278 targets CALD1 and suppresses the progression of gastric cancer via the MAPK pathway
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  211. ENPP1 ameliorates vascular calcification via inhibiting the osteogenic transformation of VSMCs and generating PPi
  212. Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes
  213. The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study
  214. Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units
  215. Identification of diagnostic immune-related gene biomarkers for predicting heart failure after acute myocardial infarction
  216. Long-term administration of probiotics prevents gastrointestinal mucosal barrier dysfunction in septic mice partly by upregulating the 5-HT degradation pathway
  217. miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor
  218. Diagnostic and prognostic value of MR-pro ADM, procalcitonin, and copeptin in sepsis
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  222. Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
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  224. Vitamin C and epigenetics: A short physiological overview
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  233. Case Reports
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  247. Rapid Communication
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  249. Erratum
  250. Erratum to “Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway”
  251. Erratum to: “Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p”
  252. Retraction
  253. Retraction of “Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients”
  254. Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
  255. Retraction of “miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells”
  256. Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”
  257. Retraction of “circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury”
  258. Retraction of “lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells”
  259. Special issue Linking Pathobiological Mechanisms to Clinical Application for cardiovascular diseases
  260. Effect of cardiac rehabilitation therapy on depressed patients with cardiac insufficiency after cardiac surgery
  261. Special issue The evolving saga of RNAs from bench to bedside - Part I
  262. FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma
  263. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part III
  264. Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer
https://doi.org/10.1515/med-2023-0688
Schlagwörter für diesen Artikel
ascorbic acid; epigenetics; DNA methylation; histone modification
Creative Commons
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Artikel in diesem Heft

  1. Research Articles
  2. Exosomes derived from mesenchymal stem cells overexpressing miR-210 inhibits neuronal inflammation and contribute to neurite outgrowth through modulating microglia polarization
  3. Current situation of acute ST-segment elevation myocardial infarction in a county hospital chest pain center during an epidemic of novel coronavirus pneumonia
  4. circ-IARS depletion inhibits the progression of non-small-cell lung cancer by circ-IARS/miR-1252-5p/HDGF ceRNA pathway
  5. circRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma
  6. WDR79 promotes aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) by the suppression of SIRT4
  7. Up-regulation of collagen type V alpha 2 (COL5A2) promotes malignant phenotypes in gastric cancer cell via inducing epithelial–mesenchymal transition (EMT)
  8. Inhibition of TERC inhibits neural apoptosis and inflammation in spinal cord injury through Akt activation and p-38 inhibition via the miR-34a-5p/XBP-1 axis
  9. 3D-printed polyether-ether-ketone/n-TiO2 composite enhances the cytocompatibility and osteogenic differentiation of MC3T3-E1 cells by downregulating miR-154-5p
  10. Propofol-mediated circ_0000735 downregulation restrains tumor growth by decreasing integrin-β1 expression in non-small cell lung cancer
  11. PVT1/miR-16/CCND1 axis regulates gastric cancer progression
  12. Silencing of circ_002136 sensitizes gastric cancer to paclitaxel by targeting the miR-16-5p/HMGA1 axis
  13. Short-term outcomes after simultaneous gastrectomy plus cholecystectomy in gastric cancer: A pooling up analysis
  14. SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways
  15. Molecular mechanism by which the Notch signaling pathway regulates autophagy in a rat model of pulmonary fibrosis in pigeon breeder’s lung
  16. lncRNA TPT1-AS1 promotes cell migration and invasion in esophageal squamous-cell carcinomas by regulating the miR-26a/HMGA1 axis
  17. SIRT1/APE1 promotes the viability of gastric cancer cells by inhibiting p53 to suppress ferroptosis
  18. Glycoprotein non-metastatic melanoma B interacts with epidermal growth factor receptor to regulate neural stem cell survival and differentiation
  19. Treatments for brain metastases from EGFR/ALK-negative/unselected NSCLC: A network meta-analysis
  20. Association of osteoporosis and skeletal muscle loss with serum type I collagen carboxyl-terminal peptide β glypeptide: A cross-sectional study in elder Chinese population
  21. circ_0000376 knockdown suppresses non-small cell lung cancer cell tumor properties by the miR-545-3p/PDPK1 pathway
  22. Delivery in a vertical birth chair supported by freedom of movement during labor: A randomized control trial
  23. UBE2J1 knockdown promotes cell apoptosis in endometrial cancer via regulating PI3K/AKT and MDM2/p53 signaling
  24. Metabolic resuscitation therapy in critically ill patients with sepsis and septic shock: A pilot prospective randomized controlled trial
  25. Lycopene ameliorates locomotor activity and urinary frequency induced by pelvic venous congestion in rats
  26. UHRF1-induced connexin26 methylation is involved in hearing damage triggered by intermittent hypoxia in neonatal rats
  27. LINC00511 promotes melanoma progression by targeting miR-610/NUCB2
  28. Ultra-high-performance liquid chromatography-tandem mass spectrometry analysis of serum metabolomic characteristics in people with different vitamin D levels
  29. Role of Jumonji domain-containing protein D3 and its inhibitor GSK-J4 in Hashimoto’s thyroiditis
  30. circ_0014736 induces GPR4 to regulate the biological behaviors of human placental trophoblast cells through miR-942-5p in preeclampsia
  31. Monitoring of sirolimus in the whole blood samples from pediatric patients with lymphatic anomalies
  32. Effects of osteogenic growth peptide C-terminal pentapeptide and its analogue on bone remodeling in an osteoporosis rat model
  33. A novel autophagy-related long non-coding RNAs signature predicting progression-free interval and I-131 therapy benefits in papillary thyroid carcinoma
  34. WGCNA-based identification of potential targets and pathways in response to treatment in locally advanced breast cancer patients
  35. Radiomics model using preoperative computed tomography angiography images to differentiate new from old emboli of acute lower limb arterial embolism
  36. Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks
  37. Single-arm trial to evaluate the efficacy and safety of baclofen in treatment of intractable hiccup caused by malignant tumor chemotherapy
  38. Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk
  39. Efficacy of immune checkpoint inhibitors in patients with KRAS-mutant advanced non-small cell lung cancer: A retrospective analysis
  40. Pyroptosis-based risk score predicts prognosis and drug sensitivity in lung adenocarcinoma
  41. Upregulation of lncRNA LANCL1-AS1 inhibits the progression of non-small-cell lung cancer via the miR-3680-3p/GMFG axis
  42. CircRANBP17 modulated KDM1A to regulate neuroblastoma progression by sponging miR-27b-3p
  43. Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS9
  44. Downregulation of RBM17 enhances cisplatin sensitivity and inhibits cell invasion in human hypopharyngeal cancer cells
  45. HDAC5-mediated PRAME regulates the proliferation, migration, invasion, and EMT of laryngeal squamous cell carcinoma via the PI3K/AKT/mTOR signaling pathway
  46. The association between sleep duration, quality, and nonalcoholic fatty liver disease: A cross-sectional study
  47. Myostatin silencing inhibits podocyte apoptosis in membranous nephropathy through Smad3/PKA/NOX4 signaling pathway
  48. A novel long noncoding RNA AC125257.1 facilitates colorectal cancer progression by targeting miR-133a-3p/CASC5 axis
  49. Impact of omicron wave and associated control measures in Shanghai on health management and psychosocial well-being of patients with chronic conditions
  50. Clinicopathological characteristics and prognosis of young patients aged ≤45 years old with non-small cell lung cancer
  51. TMT-based comprehensive proteomic profiling identifies serum prognostic signatures of acute myeloid leukemia
  52. The dose limits of teeth protection for patients with nasopharyngeal carcinoma undergoing radiotherapy based on the early oral health-related quality of life
  53. miR-30b-5p targeting GRIN2A inhibits hippocampal damage in epilepsy
  54. Long non-coding RNA AL137789.1 promoted malignant biological behaviors and immune escape of pancreatic carcinoma cells
  55. IRF6 and FGF1 polymorphisms in non-syndromic cleft lip with or without cleft palate in the Polish population
  56. Comprehensive analysis of the role of SFXN family in breast cancer
  57. Efficacy of bronchoscopic intratumoral injection of endostar and cisplatin in lung squamous cell carcinoma patients underwent conventional chemoradiotherapy
  58. Silencing of long noncoding RNA MIAT inhibits the viability and proliferation of breast cancer cells by promoting miR-378a-5p expression
  59. AG1024, an IGF-1 receptor inhibitor, ameliorates renal injury in rats with diabetic nephropathy via the SOCS/JAK2/STAT pathway
  60. Downregulation of KIAA1199 alleviated the activation, proliferation, and migration of hepatic stellate cells by the inhibition of epithelial–mesenchymal transition
  61. Exendin-4 regulates the MAPK and WNT signaling pathways to alleviate the osteogenic inhibition of periodontal ligament stem cells in a high glucose environment
  62. Inhibition of glycolysis represses the growth and alleviates the endoplasmic reticulum stress of breast cancer cells by regulating TMTC3
  63. The function of lncRNA EMX2OS/miR-653-5p and its regulatory mechanism in lung adenocarcinoma
  64. Tectorigenin alleviates the apoptosis and inflammation in spinal cord injury cell model through inhibiting insulin-like growth factor-binding protein 6
  65. Ultrasound examination supporting CT or MRI in the evaluation of cervical lymphadenopathy in patients with irradiation-treated head and neck cancer
  66. F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway
  67. Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis
  68. Long noncoding RNA Mhrt alleviates angiotensin II-induced cardiac hypertrophy phenotypes by mediating the miR-765/Wnt family member 7B pathway
  69. Effect of miR-499-5p/SOX6 axis on atrial fibrosis in rats with atrial fibrillation
  70. Cholesterol induces inflammation and reduces glucose utilization
  71. circ_0004904 regulates the trophoblast cell in preeclampsia via miR-19b-3p/ARRDC3 axis
  72. NECAB3 promotes the migration and invasion of liver cancer cells through HIF-1α/RIT1 signaling pathway
  73. The poor performance of cardiovascular risk scores in identifying patients with idiopathic inflammatory myopathies at high cardiovascular risk
  74. miR-2053 inhibits the growth of ovarian cancer cells by downregulating SOX4
  75. Nucleophosmin 1 associating with engulfment and cell motility protein 1 regulates hepatocellular carcinoma cell chemotaxis and metastasis
  76. α-Hederin regulates macrophage polarization to relieve sepsis-induced lung and liver injuries in mice
  77. Changes of microbiota level in urinary tract infections: A meta-analysis
  78. Identification of key enzalutamide-resistance-related genes in castration-resistant prostate cancer and verification of RAD51 functions
  79. Falls during oxaliplatin-based chemotherapy for gastrointestinal malignancies – (lessons learned from) a prospective study
  80. Outcomes of low-risk birth care during the Covid-19 pandemic: A cohort study from a tertiary care center in Lithuania
  81. Vitamin D protects intestines from liver cirrhosis-induced inflammation and oxidative stress by inhibiting the TLR4/MyD88/NF-κB signaling pathway
  82. Integrated transcriptome analysis identifies APPL1/RPS6KB2/GALK1 as immune-related metastasis factors in breast cancer
  83. Genomic analysis of immunogenic cell death-related subtypes for predicting prognosis and immunotherapy outcomes in glioblastoma multiforme
  84. Circular RNA Circ_0038467 promotes the maturation of miRNA-203 to increase lipopolysaccharide-induced apoptosis of chondrocytes
  85. An economic evaluation of fine-needle cytology as the primary diagnostic tool in the diagnosis of lymphadenopathy
  86. Midazolam impedes lung carcinoma cell proliferation and migration via EGFR/MEK/ERK signaling pathway
  87. Network pharmacology combined with molecular docking and experimental validation to reveal the pharmacological mechanism of naringin against renal fibrosis
  88. PTPN12 down-regulated by miR-146b-3p gene affects the malignant progression of laryngeal squamous cell carcinoma
  89. miR-141-3p accelerates ovarian cancer progression and promotes M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway
  90. lncRNA OIP5-AS1 attenuates the osteoarthritis progression in IL-1β-stimulated chondrocytes
  91. Overexpression of LINC00607 inhibits cell growth and aggressiveness by regulating the miR-1289/EFNA5 axis in non-small-cell lung cancer
  92. Subjective well-being in informal caregivers during the COVID-19 pandemic
  93. Nrf2 protects against myocardial ischemia-reperfusion injury in diabetic rats by inhibiting Drp1-mediated mitochondrial fission
  94. Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2B
  95. Bladder cancer screening: The new selection and prediction model
  96. circNFATC3 facilitated the progression of oral squamous cell carcinoma via the miR-520h/LDHA axis
  97. Prone position effect in intensive care patients with SARS-COV-2 pneumonia
  98. Clinical observation on the efficacy of Tongdu Tuina manipulation in the treatment of primary enuresis in children
  99. Dihydroartemisinin ameliorates cerebral I/R injury in rats via regulating VWF and autophagy-mediated SIRT1/FOXO1 pathway
  100. Knockdown of circ_0113656 assuages oxidized low-density lipoprotein-induced vascular smooth muscle cell injury through the miR-188-3p/IGF2 pathway
  101. Low Ang-(1–7) and high des-Arg9 bradykinin serum levels are correlated with cardiovascular risk factors in patients with COVID-19
  102. Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study
  103. Potential protective effects of Huanglian Jiedu Decoction against COVID-19-associated acute kidney injury: A network-based pharmacological and molecular docking study
  104. Clinical significance of serum MBD3 detection in girls with central precocious puberty
  105. Clinical features of varicella-zoster virus caused neurological diseases detected by metagenomic next-generation sequencing
  106. Collagen treatment of complex anorectal fistula: 3 years follow-up
  107. LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through down-regulating SP-A by sponging to miR-424
  108. Efficacy analysis of empirical bismuth quadruple therapy, high-dose dual therapy, and resistance gene-based triple therapy as a first-line Helicobacter pylori eradication regimen – An open-label, randomized trial
  109. SMOC2 plays a role in heart failure via regulating TGF-β1/Smad3 pathway-mediated autophagy
  110. A prospective cohort study of the impact of chronic disease on fall injuries in middle-aged and older adults
  111. circRNA THBS1 silencing inhibits the malignant biological behavior of cervical cancer cells via the regulation of miR-543/HMGB2 axis
  112. hsa_circ_0000285 sponging miR-582-3p promotes neuroblastoma progression by regulating the Wnt/β-catenin signaling pathway
  113. Long non-coding RNA GNAS-AS1 knockdown inhibits proliferation and epithelial–mesenchymal transition of lung adenocarcinoma cells via the microRNA-433-3p/Rab3A axis
  114. lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation
  115. Twenty-four-color full spectrum flow cytometry panel for minimal residual disease detection in acute myeloid leukemia
  116. Hsa-miR-223-3p participates in the process of anthracycline-induced cardiomyocyte damage by regulating NFIA gene
  117. Anti-inflammatory effect of ApoE23 on Salmonella typhimurium-induced sepsis in mice
  118. Analysis of somatic mutations and key driving factors of cervical cancer progression
  119. Hsa_circ_0028007 regulates the progression of nasopharyngeal carcinoma through the miR-1179/SQLE axis
  120. Variations in sexual function after laparoendoscopic single-site hysterectomy in women with benign gynecologic diseases
  121. Effects of pharmacological delay with roxadustat on multi-territory perforator flap survival in rats
  122. Analysis of heroin effects on calcium channels in rat cardiomyocytes based on transcriptomics and metabolomics
  123. Risk factors of recurrent bacterial vaginosis among women of reproductive age: A cross-sectional study
  124. Alkbh5 plays indispensable roles in maintaining self-renewal of hematopoietic stem cells
  125. Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients
  126. Correlation between microvessel maturity and ISUP grades assessed using contrast-enhanced transrectal ultrasonography in prostate cancer
  127. The protective effect of caffeic acid phenethyl ester in the nephrotoxicity induced by α-cypermethrin
  128. Norepinephrine alleviates cyclosporin A-induced nephrotoxicity by enhancing the expression of SFRP1
  129. Effect of RUNX1/FOXP3 axis on apoptosis of T and B lymphocytes and immunosuppression in sepsis
  130. The function of Foxp1 represses β-adrenergic receptor transcription in the occurrence and development of bladder cancer through STAT3 activity
  131. Risk model and validation of carbapenem-resistant Klebsiella pneumoniae infection in patients with cerebrovascular disease in the ICU
  132. Calycosin protects against chronic prostatitis in rats via inhibition of the p38MAPK/NF-κB pathway
  133. Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia
  134. The safety and immunogenicity to inactivated COVID-19 vaccine in patients with hyperlipemia
  135. Circ-UBR4 regulates the proliferation, migration, inflammation, and apoptosis in ox-LDL-induced vascular smooth muscle cells via miR-515-5p/IGF2 axis
  136. Clinical characteristics of current COVID-19 rehabilitation outpatients in China
  137. Luteolin alleviates ulcerative colitis in rats via regulating immune response, oxidative stress, and metabolic profiling
  138. miR-199a-5p inhibits aortic valve calcification by targeting ATF6 and GRP78 in valve interstitial cells
  139. The application of iliac fascia space block combined with esketamine intravenous general anesthesia in PFNA surgery of the elderly: A prospective, single-center, controlled trial
  140. Elevated blood acetoacetate levels reduce major adverse cardiac and cerebrovascular events risk in acute myocardial infarction
  141. The effects of progesterone on the healing of obstetric anal sphincter damage in female rats
  142. Identification of cuproptosis-related genes for predicting the development of prostate cancer
  143. Lumican silencing ameliorates β-glycerophosphate-mediated vascular smooth muscle cell calcification by attenuating the inhibition of APOB on KIF2C activity
  144. Targeting PTBP1 blocks glutamine metabolism to improve the cisplatin sensitivity of hepatocarcinoma cells through modulating the mRNA stability of glutaminase
  145. A single center prospective study: Influences of different hip flexion angles on the measurement of lumbar spine bone mineral density by dual energy X-ray absorptiometry
  146. Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis
  147. Antibiotics therapy combined with probiotics administered intravaginally for the treatment of bacterial vaginosis: A systematic review and meta-analysis
  148. Construction of a ceRNA network to reveal a vascular invasion associated prognostic model in hepatocellular carcinoma
  149. A pan-cancer analysis of STAT3 expression and genetic alterations in human tumors
  150. A prognostic signature based on seven T-cell-related cell clustering genes in bladder urothelial carcinoma
  151. Pepsin concentration in oral lavage fluid of rabbit reflux model constructed by dilating the lower esophageal sphincter
  152. The antihypertensive felodipine shows synergistic activity with immune checkpoint blockade and inhibits tumor growth via NFAT1 in LUSC
  153. Tanshinone IIA attenuates valvular interstitial cells’ calcification induced by oxidized low density lipoprotein via reducing endoplasmic reticulum stress
  154. AS-IV enhances the antitumor effects of propofol in NSCLC cells by inhibiting autophagy
  155. Establishment of two oxaliplatin-resistant gallbladder cancer cell lines and comprehensive analysis of dysregulated genes
  156. Trial protocol: Feasibility of neuromodulation with connectivity-guided intermittent theta-burst stimulation for improving cognition in multiple sclerosis
  157. LncRNA LINC00592 mediates the promoter methylation of WIF1 to promote the development of bladder cancer
  158. Factors associated with gastrointestinal dysmotility in critically ill patients
  159. Mechanisms by which spinal cord stimulation intervenes in atrial fibrillation: The involvement of the endothelin-1 and nerve growth factor/p75NTR pathways
  160. Analysis of two-gene signatures and related drugs in small-cell lung cancer by bioinformatics
  161. Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1
  162. Menstrual irregularities associated with COVID-19 vaccines among women in Saudi Arabia: A survey during 2022
  163. Ferroptosis involves in Schwann cell death in diabetic peripheral neuropathy
  164. The effect of AQP4 on tau protein aggregation in neurodegeneration and persistent neuroinflammation after cerebral microinfarcts
  165. Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin resistance
  166. Analysis of clinical characteristics in proximal and distal reflux monitoring among patients with gastroesophageal reflux disease
  167. Exosomal circ-0020887 and circ-0009590 as novel biomarkers for the diagnosis and prediction of short-term adverse cardiovascular outcomes in STEMI patients
  168. Upregulated microRNA-429 confers endometrial stromal cell dysfunction by targeting HIF1AN and regulating the HIF1A/VEGF pathway
  169. Bibliometrics and knowledge map analysis of ultrasound-guided regional anesthesia
  170. Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways
  171. D-dimer trends predict COVID-19 patient’s prognosis: A retrospective chart review study
  172. WTAP affects intracranial aneurysm progression by regulating m6A methylation modification
  173. Using of endoscopic polypectomy in patients with diagnosed malignant colorectal polyp – The cross-sectional clinical study
  174. Anti-S100A4 antibody administration alleviates bronchial epithelial–mesenchymal transition in asthmatic mice
  175. Prognostic evaluation of system immune-inflammatory index and prognostic nutritional index in double expressor diffuse large B-cell lymphoma
  176. Prevalence and antibiogram of bacteria causing urinary tract infection among patients with chronic kidney disease
  177. Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?
  178. Identification of disulfidptosis-related genes and immune infiltration in lower-grade glioma
  179. A new technique for uterine-preserving pelvic organ prolapse surgery: Laparoscopic rectus abdominis hysteropexy for uterine prolapse by comparing with traditional techniques
  180. Self-isolation of an Italian long-term care facility during COVID-19 pandemic: A comparison study on care-related infectious episodes
  181. A comparative study on the overlapping effects of clinically applicable therapeutic interventions in patients with central nervous system damage
  182. Low intensity extracorporeal shockwave therapy for chronic pelvic pain syndrome: Long-term follow-up
  183. The diagnostic accuracy of touch imprint cytology for sentinel lymph node metastases of breast cancer: An up-to-date meta-analysis of 4,073 patients
  184. Mortality associated with Sjögren’s syndrome in the United States in the 1999–2020 period: A multiple cause-of-death study
  185. CircMMP11 as a prognostic biomarker mediates miR-361-3p/HMGB1 axis to accelerate malignant progression of hepatocellular carcinoma
  186. Analysis of the clinical characteristics and prognosis of adult de novo acute myeloid leukemia (none APL) with PTPN11 mutations
  187. KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
  188. Evaluation of placental oxygenation by near-infrared spectroscopy in relation to ultrasound maturation grade in physiological term pregnancies
  189. The role of ultrasonographic findings for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2-negative breast cancer
  190. Construction of immunogenic cell death-related molecular subtypes and prognostic signature in colorectal cancer
  191. Long-term prognostic value of high-sensitivity cardiac troponin-I in patients with idiopathic dilated cardiomyopathy
  192. Establishing a novel Fanconi anemia signaling pathway-associated prognostic model and tumor clustering for pediatric acute myeloid leukemia patients
  193. Integrative bioinformatics analysis reveals STAT2 as a novel biomarker of inflammation-related cardiac dysfunction in atrial fibrillation
  194. Adipose-derived stem cells repair radiation-induced chronic lung injury via inhibiting TGF-β1/Smad 3 signaling pathway
  195. Real-world practice of idiopathic pulmonary fibrosis: Results from a 2000–2016 cohort
  196. lncRNA LENGA sponges miR-378 to promote myocardial fibrosis in atrial fibrillation
  197. Diagnostic value of urinary Tamm-Horsfall protein and 24 h urine osmolality for recurrent calcium oxalate stones of the upper urinary tract: Cross-sectional study
  198. The value of color Doppler ultrasonography combined with serum tumor markers in differential diagnosis of gastric stromal tumor and gastric cancer
  199. The spike protein of SARS-CoV-2 induces inflammation and EMT of lung epithelial cells and fibroblasts through the upregulation of GADD45A
  200. Mycophenolate mofetil versus cyclophosphamide plus in patients with connective tissue disease-associated interstitial lung disease: Efficacy and safety analysis
  201. MiR-1278 targets CALD1 and suppresses the progression of gastric cancer via the MAPK pathway
  202. Metabolomic analysis of serum short-chain fatty acid concentrations in a mouse of MPTP-induced Parkinson’s disease after dietary supplementation with branched-chain amino acids
  203. Cimifugin inhibits adipogenesis and TNF-α-induced insulin resistance in 3T3-L1 cells
  204. Predictors of gastrointestinal complaints in patients on metformin therapy
  205. Prescribing patterns in patients with chronic obstructive pulmonary disease and atrial fibrillation
  206. A retrospective analysis of the effect of latent tuberculosis infection on clinical pregnancy outcomes of in vitro fertilization–fresh embryo transferred in infertile women
  207. Appropriateness and clinical outcomes of short sustained low-efficiency dialysis: A national experience
  208. miR-29 regulates metabolism by inhibiting JNK-1 expression in non-obese patients with type 2 diabetes mellitus and NAFLD
  209. Clinical features and management of lymphoepithelial cyst
  210. Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia
  211. ENPP1 ameliorates vascular calcification via inhibiting the osteogenic transformation of VSMCs and generating PPi
  212. Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes
  213. The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study
  214. Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units
  215. Identification of diagnostic immune-related gene biomarkers for predicting heart failure after acute myocardial infarction
  216. Long-term administration of probiotics prevents gastrointestinal mucosal barrier dysfunction in septic mice partly by upregulating the 5-HT degradation pathway
  217. miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor
  218. Diagnostic and prognostic value of MR-pro ADM, procalcitonin, and copeptin in sepsis
  219. Review Articles
  220. Prenatal diagnosis of fetal defects and its implications on the delivery mode
  221. Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis
  222. Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
  223. Saddle pulmonary embolism in the setting of COVID-19 infection: A systematic review of case reports and case series
  224. Vitamin C and epigenetics: A short physiological overview
  225. Ebselen: A promising therapy protecting cardiomyocytes from excess iron in iron-overloaded thalassemia patients
  226. Aspirin versus LMWH for VTE prophylaxis after orthopedic surgery
  227. Mechanism of rhubarb in the treatment of hyperlipidemia: A recent review
  228. Surgical management and outcomes of traumatic global brachial plexus injury: A concise review and our center approach
  229. The progress of autoimmune hepatitis research and future challenges
  230. METTL16 in human diseases: What should we do next?
  231. New insights into the prevention of ureteral stents encrustation
  232. VISTA as a prospective immune checkpoint in gynecological malignant tumors: A review of the literature
  233. Case Reports
  234. Mycobacterium xenopi infection of the kidney and lymph nodes: A case report
  235. Genetic mutation of SLC6A20 (c.1072T > C) in a family with nephrolithiasis: A case report
  236. Chronic hepatitis B complicated with secondary hemochromatosis was cured clinically: A case report
  237. Liver abscess complicated with multiple organ invasive infection caused by hematogenous disseminated hypervirulent Klebsiella pneumoniae: A case report
  238. Urokinase-based lock solutions for catheter salvage: A case of an upcoming kidney transplant recipient
  239. Two case reports of maturity-onset diabetes of the young type 3 caused by the hepatocyte nuclear factor 1α gene mutation
  240. Immune checkpoint inhibitor-related pancreatitis: What is known and what is not
  241. Does total hip arthroplasty result in intercostal nerve injury? A case report and literature review
  242. Clinicopathological characteristics and diagnosis of hepatic sinusoidal obstruction syndrome caused by Tusanqi – Case report and literature review
  243. Synchronous triple primary gastrointestinal malignant tumors treated with laparoscopic surgery: A case report
  244. CT-guided percutaneous microwave ablation combined with bone cement injection for the treatment of transverse metastases: A case report
  245. Malignant hyperthermia: Report on a successful rescue of a case with the highest temperature of 44.2°C
  246. Anesthetic management of fetal pulmonary valvuloplasty: A case report
  247. Rapid Communication
  248. Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
  249. Erratum
  250. Erratum to “Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway”
  251. Erratum to: “Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p”
  252. Retraction
  253. Retraction of “Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients”
  254. Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
  255. Retraction of “miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells”
  256. Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”
  257. Retraction of “circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury”
  258. Retraction of “lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells”
  259. Special issue Linking Pathobiological Mechanisms to Clinical Application for cardiovascular diseases
  260. Effect of cardiac rehabilitation therapy on depressed patients with cardiac insufficiency after cardiac surgery
  261. Special issue The evolving saga of RNAs from bench to bedside - Part I
  262. FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma
  263. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part III
  264. Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer
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Heruntergeladen am 23.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/med-2023-0688/html
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