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lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation

  • Wenming Chen EMAIL logo , Wei Zhao , Minghui Hao and Yuping Wang
Published/Copyright: July 25, 2023
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Open Medicine
From the journal Open Medicine Volume 18 Issue 1

Abstract

UCA1 is predicted to bind to miR-132, which is a key player in the proliferation of vascular smooth muscle cells (VSMCs). This research studied the role of lncRNA UCA1 in atherosclerosis. The binding of UCA1 to miR-132 was proved by dual luciferase activity assay and RNA immunoprecipitation. UCA1 and miR-132 failed to affect each other’s expression in VSMCs. UCA1 was upregulated and miR-132 was decreased in atherosclerosis plasma. However, they are not closely correlated across atherosclerosis and control plasma sample. Interestingly, UCA1 suppressed the role of miR-132 in downregulating Lrrfip1 expression and promoting VSMC proliferation. Therefore, UCA1 is downregulated in atherosclerosis and may regulate miR-132/Lrrfip1 axis to promote VSMC proliferation.

Keywords: lncRNA UCA1; atherosclerosis; miR-132; Lrrfip1; proliferation

1 Introduction

Atherosclerosis is a common clinical disorder of the medium- and large-sized muscular arteries caused by the formation of plaques [1]. The formation of plaque in arteries will block the supply of nutrition and oxygen to multiple important organs, such as kidney, heart, and brain, leading to a series of severe clinical disorders, such as kidney failure, heart attack, and stroke [2,3,4]. In Western counties, such as the United States, atherosclerosis is considered as the leading cause of deaths and illness [5]. In spite of the efforts made on the treatment of atherosclerosis, this disease still cannot be fully reverse, especially for the patients with advanced lesions. Therefore, novel therapeutic approaches are still needed [6].

The development and progression of atherosclerosis is a complicated process [7]. The component cells of plaque are vascular smooth muscle cells (VSMCs) [8,9]. It has been well established that the aberrant proliferation and apoptosis of VSMCs contribute to the development of atherosclerosis [8,9]. Therefore, VSMCs are promising target for atherosclerosis treatment [8]. Proliferation of VSMCs requires the participation of molecular players [1]. The sequences of lncRNAs contain no coding information, while they interact with other molecular players, such as proteins, DNAs, and miRNAs, to participate in the regulation of VSMCs [2]. FOXC2-AS1 has been reported to regulate the proliferation and apoptosis of VSMCs via regulating miR-1253/FOXF1 axis in atherosclerosis [3]. Moreover, in a recent study, Tian et al. reported that lncRNA UCA1 could regulate the proliferation of VSMCs by sponging miR-26a [10]. Recently, high expression levels of miR-132 during embryonic angiogenesis were reported to induce pathological angiogenesis via regulating p120RasGTPase activating protein 1, which modulates normal endothelial function [4]. Moreover, miR-132 has been reported to block VSMC proliferation and neointimal hyperplasia via regulating Lrrfip1 [5]. However, it is unclear whether UCA1-regulated miR-132 participates in atherosclerosis. Lrrfip1, or LRR binding FLII interacting protein 1, can promote the proliferation of VSMCs [11], and some miRNAs, such as miR-132, can target Lrrfip1 to suppress the proliferation of VSMCs [11]. It is not clear whether UCA1 regulates the proliferation of VSMCs through the miR-132/LRRFIP1 axis. UCA1 in this research was predicted to bind to miR-132. The crosstalk between UCA1 and miR-132 in atherosclerosis was therefore analyzed in this research.

2 Methods

2.1 Plasma samples

Blood (5 mL) was extracted from 55 atherosclerosis patients (30 males and 25 females, 24–37 years and 30.1 ± 3.8 years) and 55 healthy controls (30 males and 25 females, 24–37 years and 30.2 ± 3.9 years) under fasting conditions. All the participants were enrolled at Beijing Luhe Hospital, Capital Medical University, between March 2017 and March 2018, and informed consent was obtained. All atherosclerosis patients were diagnosed by blood test to check the level of cholesterol and Doppler ultrasound to check blockage in arteries. All healthy controls showed normal physiological functions. Blood samples were used to prepare plasma samples, which were stored in liquid nitrogen before use. The demographic and clinicopathological characteristics of the patients were recorded and are listed in Table 1.

Table 1

Baseline demographic characteristics between two groups

Parameter Atherosclerosis group (n = 55) Control group (n = 55) p values
Age 30.1 ± 3.8 30.2 ± 3.9 0.789
Sex (female/male) 25/30 25/30 0.689
Smoking 32 34 0.812
Drinking 41 40 0.855
Hypertension 41 12 0.004
Diabetes 46 6 0.001
TG (mmol/L) 1.73 ± 0.26 1.62 ± 0.31 0.321
TC (mmol/L) 5.20 ± 0.87 4.37 ± 0.76 0.003
HDL-C (mmol/L) 1.16 ± 0.25 1.30 ± 0.33 0.031
LDL-C (mmol/L) 2.82 ± 0.63 2.41 ± 0.11 0.024

Data are reported as means ± SD. p < 0.05 was considered significant. TG: Triglyceride; TC: Total cholesterol; HDL-C: Fasting high-density lipoprotein cholesterol; LDL-C: Fasting low-density lipoprotein cholesterol.

  1. Ethics approval: This study was approved by the Ethics Committee of the Beijing Luhe Hospital, Capital Medical University. The research has been carried out in accordance with the World Medical Association Declaration of Helsinki. All patients and control volunteers provided written informed consent prior to their inclusion within the study.

2.2 Human aortic smooth muscle cells (HAOSMCs) and lipofectamine 2000-mediated cell transfection

HAOSMCs (354-05A; Sigma-Aldrich, St. Louis, MO, USA) were used in this study. HAOSMCs were cultivated until about 80% confluence to perform the following transfection. To perform the overexpression experiments, UCA1 and Lrrfip1 expression vectors were constructed with pcDNA3.1. Negative control (NC) miRNA (5′-UGUUGUACGUAGUGUCGAUCCCA-3′) and miR-132 mimic (5′- UAACAGUCUACAGCCAUGGUCG-3′) were purchased from Sigma-Aldrich (USA). HAOSMCs were transfected with UCA1 or Lrrfip1 expression vector (10 nM) or miR-132 mimic (40 nM) using lipofectamine 2000 (Invitrogen, Shanghai, China). To perform dual luciferase activity assay, pGL3 vector (Promega) was used to construct UCA1 luciferase vector. HAOSMCs were co-transfected with UCA1 vector + miR-132 mimic (miR-132 group) or UCA1 vector + NC miRNA (NC group). Cells were harvested at 48 h post-transfection for the confirmation of overexpression or the measurement of luciferase activity.

2.3 RNA preparations and RT-qPCR

Trizol reagent (Invitrogen, Shanghai, China) was mixed with plasma or HAOSMCs to extract total RNAs. All steps were performed according to the instructions from Invitrogen, and 85% ethanol was used to precipitate RNA samples to harvest miRNAs. Two all-in-one kits from Genecopoeia (Guangzhou, China), namely, BlazeTaq™ One-Step SYBR Green real-time quantitative polymerase chain reaction (RT-qPCR) Kit (for UCA1 and Lrrfip1 mRNA) and All-in-One™ miRNA qRT-PCR Reagent Kit (for miR-132), were used to measure the expression levels of each gene using GAPDH and U6 endogenous controls. Each polymerase chain reaction was repeated three times, and gene expression levels were normalized to endogenous controls using the 2−ΔΔCT method. Primer sequences were as follows: 5′-TTTGCCAGCCTCAGCTTAAT-3′ (forward); 5′-TTGTCCCCATTTTCCATCAT-3′ (reverse) for UCA1; 5′-ATGAGTTAAAGGACCAGATT-3′ (forward); 5′-TCAACCTGGTACATGAAGTT-3′ (reverse) for UCA1; 5′-GTCTCCTCTGACTTCA-3′ (forward); 5′-CCACCCTGTTGCTGTA-3′ (reverse) for GAPDH. The forward primer of miR-132 was 5′- TAACAGTCTACAGCCATG-3′. The forward primer of U6 and the universal reverse primer were used from the kit.

2.4 Western blot

Radioimmune precipitation assay solution (Invitrogen, Shanghai, China) was mixed with HAOSMCs to prepare protein samples, which were quantified using bicinchoninic acid assay (Invitrogen, Shanghai, China). Protein samples were incubated at 95°C for 10 min to reach protein denaturation. After electrophoresis (10% sodium dodecyl sulfate-polyacrylamide gel electrophoresis gel), gel transfer, and blocking, incubation with rabbit primary antibodies of Lrrfip1 (ab103148, Abcam, Cambridge, UK) and GAPDH (ab9485, Abcam, Cambridge, UK) and secondary antibody of HRP Goat Anti-Rabbit (IgG) (ab97051, Abcam, Cambridge, UK) was performed. ECL™ Detection Reagent (Sigma-Aldrich, St. Louis, MO, USA) was used to produce signals, which were normalized using Quantity One software.

2.5 Cell proliferation analysis

HAOSMCs were harvested at 48 h post-transfection to analyze cell proliferation. HAOSMCs were cultivated (3,000 cells in 0.1 mL medium per well of 96-well plates). Cells were cultivated at 37°C and were collected every 24 h until 96 h. CCK-8 solution was added into medium to reach 10% at 4 h before cell collection. Optical densities values at 450 nM were measured to reflect cell proliferation.

2.6 RIP

Magna RIP™ RNA-Binding Protein Immunoprecipitation Kit (Millipore) and anti-Argonaute2 (anti-Ago2) (ab32381, Abcam) or anti-IgG antibody (ab133470, Abcam) [6] were used to further validate the binding of UCA1 to miR-132. Briefly, cell lysate was co-incubated with A/G magnetic beads together with anti-Ago2 or anti-IgG antibody. After proteinase K digestion, the enrichment of UCA1 and miR-132 was detected by RT-qPCR assay.

2.7 Colony formation assay

Transfected cells were digested, counted, and cultured in a 12-well plate of 100 cells/well at 37℃ under 5% CO2 for 3 weeks. The cells were soaked in Dulbecco’s phosphate-buffered brine for two times, and 1 mL of methanol was added to each well for fixation for 15 min, and then 1 mL of Giemsa was added. Colony formation rate was assessed [7].

2.8 Dual-luciferase reporter assays

The potential binding site of miR-132 on UCA1 was cloned into pmirGLO-dual-luciferase reporter. UCA1 was co-transfected into cells with miR-132 or miR-132 (mut). The luminescent signals of Renilla firefly were calculated following the protocol provided in the double luciferase assay system (Promega) at 48 h after transfection.

2.9 Statistical analysis

Unpaired t test (two groups) and ANOVA Tukey’s test (multiple groups) were used to compare datasets. p < 0.05 was considered to be statistically significant.

3 Results

3.1 UCA1 and miR-132 can directly interact with each other

The binding of UCA1 to miR-132 was predicted with IntaRNA 2.0 [12], which showed that UCA1 could bind to miR-132 (Figure 1a). The binding of UCA1 to miR-132 was further confirmed by dual luciferase activity assay. Compared to the NC group, the miR-132 group showed a decreased luciferase activity (Figure 1b, p < 0.05). miR-132 mutant (miR-132(mut)) was designed (indicated by letters in red, Figure 1a). Dual luciferase activity was repeated using miR-132(mut). It was observed that miR-132 (mut) failed to reduce luciferase activity compared to the NC group (Figure 1c). Moreover, RNA immunoprecipitation (RIP) results (Figure 1d) suggested that UCA1 and miR-132 were accumulated in both input and anti‐Ago2 groups as compared to the anti-lgG group. Therefore, miR-132 and UCA1 may interact with each other.

Figure 1 UCA1 and miR-132 can directly interact with each other. The binding of UCA1 to miR-132 was predicted using IntaRNA (a). Dual luciferase activity assay was conducted to further confirm the interaction between them (b). Dual luciferase activity was repeated using miR-132 mutant (miR-132(mut)). It was observed that miR-132 (mut) failed to reduce luciferase activity compared to NC group (c). RIP results suggested that UCA1 and miR-132 were concentrated in both anti‐Ago2 group and input group (d). *, p < 0.05.
Figure 1

UCA1 and miR-132 can directly interact with each other. The binding of UCA1 to miR-132 was predicted using IntaRNA (a). Dual luciferase activity assay was conducted to further confirm the interaction between them (b). Dual luciferase activity was repeated using miR-132 mutant (miR-132(mut)). It was observed that miR-132 (mut) failed to reduce luciferase activity compared to NC group (c). RIP results suggested that UCA1 and miR-132 were concentrated in both anti‐Ago2 group and input group (d). *, p < 0.05.

3.2 Regulatory role of UCA1 and miR-132 in each other’s expression

HAOSMCs were overexpressed with UCA1 or miR-132 (Figure 2a, p < 0.05). miR-132 failed to affect UCA1 expression. Similarly, overexpression of UCA1 did not affect the expression of miR-132 (Figure 2b, p < 0.05). Therefore, UCA1 may not be a target of miR-132.

Figure 2 Regulatory role of UCA1 and miR-132 in each other’s expression. HAOSMCs were overexpressed with UCA1 or miR-132 (a). The effects of UCA1 and miR-132 overexpression on the expression of each other were analyzed by performing RT-qPCR at 48 h post-transfection (b). *, p < 0.05.
Figure 2

Regulatory role of UCA1 and miR-132 in each other’s expression. HAOSMCs were overexpressed with UCA1 or miR-132 (a). The effects of UCA1 and miR-132 overexpression on the expression of each other were analyzed by performing RT-qPCR at 48 h post-transfection (b). *, p < 0.05.

3.3 Plasma levels of UCA1 and miR-132 were altered in atherosclerosis patients

UCA1 was accumulated to high amounts (Figure 3a) in atherosclerosis plasma, while miR-132 was accumulated to low amounts (Figure 3b) in atherosclerosis plasma (p < 0.05). These data suggest the involvement of UCA1 and miR-132 in atherosclerosis.

Figure 3 Plasma levels of UCA1 and miR-132 were altered in atherosclerosis patients. Levels of UCA1 (a) and miR-132 (b) in plasma from atherosclerosis patients (n = 55) and healthy controls (n = 55) were measured by performing RT-qPCR. *, p < 0.05.
Figure 3

Plasma levels of UCA1 and miR-132 were altered in atherosclerosis patients. Levels of UCA1 (a) and miR-132 (b) in plasma from atherosclerosis patients (n = 55) and healthy controls (n = 55) were measured by performing RT-qPCR. *, p < 0.05.

3.4 UCA1 and miR-132 were not significantly correlated

The correlations between plasma levels of UCA1 and miR-132 across atherosclerosis and control plasma samples were analyzed. No significant correlation between plasma levels of UCA1 and miR-132 was found across plasma samples from atherosclerosis patients (Figure 4a) and healthy controls (Figure 4b). Therefore, UCA1 and miR-132 may not regulate the expression of each other in the human body.

Figure 4 Plasma levels of UCA1 and miR-132 were not significantly correlated. Correlations between plasma levels of UCA1 and miR-132 across atherosclerosis (a) and control (b) plasma samples.
Figure 4

Plasma levels of UCA1 and miR-132 were not significantly correlated. Correlations between plasma levels of UCA1 and miR-132 across atherosclerosis (a) and control (b) plasma samples.

3.5 UCA1 regulated Lrrfip1 expression though miR-132 to promote the proliferation of HAOSMCs

The aforementioned data suggested UCA1 as an endogenous sponge of miR-132. To this end, the role of UCA1 and miR-132 in regulating the expression of Lrrfip1, a direct target of miR-132, was analyzed by RT-qPCR (Figure 5a) and Western blot (Figure 5b). UCA1 overexpression suppressed the role of miR-21 in downregulating Lrrfip1 expression (p < 0.05). Original Western blot images are presented in Figure S1. Cell proliferation analysis was conducted to explore the role of UCA1, miR-132, and Lrrfip1 in HAOSMC proliferation. Compared to the C group, UCA1 and Lrrfip1 overexpression resulted in increased cell proliferation rate (Figure 5c, p < 0.05). In contrast, miR-132 overexpression played an opposite role (p < 0.05). Moreover, UCA1 overexpression reversed the effects of miR-132 overexpression on the proliferation of HAOSMCs (p < 0.05). Furthermore, colony formation assay indicated that the overexpression of UCA1 and Lrrfip1 promoted the colony formation and the overexpression of miR-132 suppressed the colony formation. Moreover, miR-132 overexpression could counteract the simulative effect of UCA1-induced on HAOSMC proliferation (Figure 5d, p < 0.05).

Figure 5 UCA1 regulated Lrrfip1 expression though miR-132 to promote the proliferation of HAOSMCs. The aforementioned data suggest UCA1 as an endogenous sponge of miR-132. To test this hypothesis, the effects of UCA1 and miR-132 overexpression on the expression of Lrrfip1, a direct target of miR-132, were analyzed by RT-qPCR (a) and western blot (b). Cell proliferation assay was performed to analyze the effects of UCA1, miR-132, and Lrrfip1 overexpression on the proliferation of HAOSMCs (c and d). *, p < 0.05.
Figure 5

UCA1 regulated Lrrfip1 expression though miR-132 to promote the proliferation of HAOSMCs. The aforementioned data suggest UCA1 as an endogenous sponge of miR-132. To test this hypothesis, the effects of UCA1 and miR-132 overexpression on the expression of Lrrfip1, a direct target of miR-132, were analyzed by RT-qPCR (a) and western blot (b). Cell proliferation assay was performed to analyze the effects of UCA1, miR-132, and Lrrfip1 overexpression on the proliferation of HAOSMCs (c and d). *, p < 0.05.

4 Discussion

This study mainly investigated the involvement of the interaction between UCA1, miR-132, and Lrrfip1 in the proliferation of HAOSMCs. We found that UCA1 was increased in atherosclerosis and may upregulate Lrrfip1 by sponging miR-132 to promote the proliferation of VSMCs.

VSMCs participate in multiple processes of the development and progression of atherosclerosis [13]. In early-stage plaque, the accelerated proliferation of VSMCs promotes the plaque formation [13]. In contrast, VSMCs in advanced-stage plaques generate extracellular matrix to induce the formation of fibrous cap to stabilize plaques, thereby preventing plaque ruptures [13]. Therefore, inhibiting VSMCs proliferation in early-stage plaque and promoting their proliferation in advanced-stage plaques may assist the treatment of atherosclerosis. A considerable number of molecular players have been identified in the proliferation of VSMCs, while their involvement in atherosclerosis is unknown. In a recent study, Choe et al. reported that miR-132 could target Lrrfip1 to inhibit VSMC proliferation in neointimal hyperplasia [14]. In this study, we observed the downregulation of miR-132 in atherosclerosis. In another study, Das et al. found that silencing of UCA1 released miR-26a and led to the reduced proliferation rate of VSMCs [11]. Consistently, we reported that UCA1 overexpression led to the increased proliferation rate of VSMCs.

Interestingly, our study showed the direct interaction between UCA1 and miR-132 in VSMCs. However, overexpression of UCA1 and miR-132 failed to affect the expression of each other. In addition, although UCA1 and miR-132 showed opposite expression patterns in atherosclerosis, they are not significantly correlated with each other across plasma samples. Our data suggested that UCA1 was unlikely a target of miR-132. However, we provided sufficient evidence to show that UCA1 and miR-132 can interact with each other. Besides being the target of miRNAs, lncRNAs may also serve as the sponge of miRNAs to suppress their functions without affecting the expression of miRNAs [15,16]. Indeed, UCA1 reduced the inhibitory effects of miR-132 on the expression of Lrrfip1 and its enhancing effects on the proliferation of VSMCs. Therefore, UCA1 is likely an endogenous competing RNA of miR-132. miR-132 expression in this study was detected using RT-qPCR, in which the high temperature will release miR-132 from UCA1. Therefore, RT-qPCR analysis revealed no role of UCA1 and miR132 in each other’s expression.

Our data suggested that the fine regulation of VSMC proliferation may serve as a target for atherosclerosis treatment. Moreover, the expression of biomarkers (UCA1, miR-132) corresponding to blood samples collected was not affected by plaque stage. However, the expression of miR132 and UCA1 in atherosclerotic tissue is unclear. Atherosclerosis and control groups in this study exhibited significantly different status of hypertension and diabetes, while hypertension, diabetes, and atherosclerosis are known to be closely associated [1,2,3,4,5]. In addition, UCA1 can also affect other miRNAs to regulate the proliferation rate of VSMCs [11]. Therefore, our conclusions require further validation.

5 Conclusion

In conclusion, UCA1 is upregulated in atherosclerosis and it may sponge miR-132 to upregulate Lrrfip1, thereby promoting the proliferation of VSMCs (Figure 6).

Figure 6 UCA1 promoted HAOSMC proliferation via the regulation of miR-132/Lrrfip1. lncRNA UCA1 may compete with miR-132 by regulating Lrrfip1 to participate in the proliferation of HAOSMCs, which suggest its critical roles in the pathogenesis of atherosclerosis.
Figure 6

UCA1 promoted HAOSMC proliferation via the regulation of miR-132/Lrrfip1. lncRNA UCA1 may compete with miR-132 by regulating Lrrfip1 to participate in the proliferation of HAOSMCs, which suggest its critical roles in the pathogenesis of atherosclerosis.

List of abbreviations

HAOSMCs

human aortic smooth muscle cells

NC

negative control

VSMCs

Vascular smooth muscle cells

# The authors contributed equally to this work.

Acknowledgements

Not applicable.

  1. Funding information: Not applicable.

  2. Author contributions: WC, WZ: study design, experiments, manuscript preparation, data collection, data analysis. MH, YW: data collection, data analysis. All authors approved this submission.

  3. Conflict of interest: Authors state no conflict of interest.

  4. Data availability statement: The analyzed data sets generated during this study are available from the corresponding author on a reasonable request.

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Received: 2022-11-12
Revised: 2023-03-15
Accepted: 2023-05-24
Published Online: 2023-07-25

© 2023 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  50. Clinicopathological characteristics and prognosis of young patients aged ≤45 years old with non-small cell lung cancer
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  52. The dose limits of teeth protection for patients with nasopharyngeal carcinoma undergoing radiotherapy based on the early oral health-related quality of life
  53. miR-30b-5p targeting GRIN2A inhibits hippocampal damage in epilepsy
  54. Long non-coding RNA AL137789.1 promoted malignant biological behaviors and immune escape of pancreatic carcinoma cells
  55. IRF6 and FGF1 polymorphisms in non-syndromic cleft lip with or without cleft palate in the Polish population
  56. Comprehensive analysis of the role of SFXN family in breast cancer
  57. Efficacy of bronchoscopic intratumoral injection of endostar and cisplatin in lung squamous cell carcinoma patients underwent conventional chemoradiotherapy
  58. Silencing of long noncoding RNA MIAT inhibits the viability and proliferation of breast cancer cells by promoting miR-378a-5p expression
  59. AG1024, an IGF-1 receptor inhibitor, ameliorates renal injury in rats with diabetic nephropathy via the SOCS/JAK2/STAT pathway
  60. Downregulation of KIAA1199 alleviated the activation, proliferation, and migration of hepatic stellate cells by the inhibition of epithelial–mesenchymal transition
  61. Exendin-4 regulates the MAPK and WNT signaling pathways to alleviate the osteogenic inhibition of periodontal ligament stem cells in a high glucose environment
  62. Inhibition of glycolysis represses the growth and alleviates the endoplasmic reticulum stress of breast cancer cells by regulating TMTC3
  63. The function of lncRNA EMX2OS/miR-653-5p and its regulatory mechanism in lung adenocarcinoma
  64. Tectorigenin alleviates the apoptosis and inflammation in spinal cord injury cell model through inhibiting insulin-like growth factor-binding protein 6
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  66. F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway
  67. Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis
  68. Long noncoding RNA Mhrt alleviates angiotensin II-induced cardiac hypertrophy phenotypes by mediating the miR-765/Wnt family member 7B pathway
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  72. NECAB3 promotes the migration and invasion of liver cancer cells through HIF-1α/RIT1 signaling pathway
  73. The poor performance of cardiovascular risk scores in identifying patients with idiopathic inflammatory myopathies at high cardiovascular risk
  74. miR-2053 inhibits the growth of ovarian cancer cells by downregulating SOX4
  75. Nucleophosmin 1 associating with engulfment and cell motility protein 1 regulates hepatocellular carcinoma cell chemotaxis and metastasis
  76. α-Hederin regulates macrophage polarization to relieve sepsis-induced lung and liver injuries in mice
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  78. Identification of key enzalutamide-resistance-related genes in castration-resistant prostate cancer and verification of RAD51 functions
  79. Falls during oxaliplatin-based chemotherapy for gastrointestinal malignancies – (lessons learned from) a prospective study
  80. Outcomes of low-risk birth care during the Covid-19 pandemic: A cohort study from a tertiary care center in Lithuania
  81. Vitamin D protects intestines from liver cirrhosis-induced inflammation and oxidative stress by inhibiting the TLR4/MyD88/NF-κB signaling pathway
  82. Integrated transcriptome analysis identifies APPL1/RPS6KB2/GALK1 as immune-related metastasis factors in breast cancer
  83. Genomic analysis of immunogenic cell death-related subtypes for predicting prognosis and immunotherapy outcomes in glioblastoma multiforme
  84. Circular RNA Circ_0038467 promotes the maturation of miRNA-203 to increase lipopolysaccharide-induced apoptosis of chondrocytes
  85. An economic evaluation of fine-needle cytology as the primary diagnostic tool in the diagnosis of lymphadenopathy
  86. Midazolam impedes lung carcinoma cell proliferation and migration via EGFR/MEK/ERK signaling pathway
  87. Network pharmacology combined with molecular docking and experimental validation to reveal the pharmacological mechanism of naringin against renal fibrosis
  88. PTPN12 down-regulated by miR-146b-3p gene affects the malignant progression of laryngeal squamous cell carcinoma
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  100. Knockdown of circ_0113656 assuages oxidized low-density lipoprotein-induced vascular smooth muscle cell injury through the miR-188-3p/IGF2 pathway
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  111. circRNA THBS1 silencing inhibits the malignant biological behavior of cervical cancer cells via the regulation of miR-543/HMGB2 axis
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  113. Long non-coding RNA GNAS-AS1 knockdown inhibits proliferation and epithelial–mesenchymal transition of lung adenocarcinoma cells via the microRNA-433-3p/Rab3A axis
  114. lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation
  115. Twenty-four-color full spectrum flow cytometry panel for minimal residual disease detection in acute myeloid leukemia
  116. Hsa-miR-223-3p participates in the process of anthracycline-induced cardiomyocyte damage by regulating NFIA gene
  117. Anti-inflammatory effect of ApoE23 on Salmonella typhimurium-induced sepsis in mice
  118. Analysis of somatic mutations and key driving factors of cervical cancer progression
  119. Hsa_circ_0028007 regulates the progression of nasopharyngeal carcinoma through the miR-1179/SQLE axis
  120. Variations in sexual function after laparoendoscopic single-site hysterectomy in women with benign gynecologic diseases
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  124. Alkbh5 plays indispensable roles in maintaining self-renewal of hematopoietic stem cells
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  128. Norepinephrine alleviates cyclosporin A-induced nephrotoxicity by enhancing the expression of SFRP1
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  131. Risk model and validation of carbapenem-resistant Klebsiella pneumoniae infection in patients with cerebrovascular disease in the ICU
  132. Calycosin protects against chronic prostatitis in rats via inhibition of the p38MAPK/NF-κB pathway
  133. Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia
  134. The safety and immunogenicity to inactivated COVID-19 vaccine in patients with hyperlipemia
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  136. Clinical characteristics of current COVID-19 rehabilitation outpatients in China
  137. Luteolin alleviates ulcerative colitis in rats via regulating immune response, oxidative stress, and metabolic profiling
  138. miR-199a-5p inhibits aortic valve calcification by targeting ATF6 and GRP78 in valve interstitial cells
  139. The application of iliac fascia space block combined with esketamine intravenous general anesthesia in PFNA surgery of the elderly: A prospective, single-center, controlled trial
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  144. Targeting PTBP1 blocks glutamine metabolism to improve the cisplatin sensitivity of hepatocarcinoma cells through modulating the mRNA stability of glutaminase
  145. A single center prospective study: Influences of different hip flexion angles on the measurement of lumbar spine bone mineral density by dual energy X-ray absorptiometry
  146. Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis
  147. Antibiotics therapy combined with probiotics administered intravaginally for the treatment of bacterial vaginosis: A systematic review and meta-analysis
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  152. The antihypertensive felodipine shows synergistic activity with immune checkpoint blockade and inhibits tumor growth via NFAT1 in LUSC
  153. Tanshinone IIA attenuates valvular interstitial cells’ calcification induced by oxidized low density lipoprotein via reducing endoplasmic reticulum stress
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  155. Establishment of two oxaliplatin-resistant gallbladder cancer cell lines and comprehensive analysis of dysregulated genes
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  157. LncRNA LINC00592 mediates the promoter methylation of WIF1 to promote the development of bladder cancer
  158. Factors associated with gastrointestinal dysmotility in critically ill patients
  159. Mechanisms by which spinal cord stimulation intervenes in atrial fibrillation: The involvement of the endothelin-1 and nerve growth factor/p75NTR pathways
  160. Analysis of two-gene signatures and related drugs in small-cell lung cancer by bioinformatics
  161. Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1
  162. Menstrual irregularities associated with COVID-19 vaccines among women in Saudi Arabia: A survey during 2022
  163. Ferroptosis involves in Schwann cell death in diabetic peripheral neuropathy
  164. The effect of AQP4 on tau protein aggregation in neurodegeneration and persistent neuroinflammation after cerebral microinfarcts
  165. Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin resistance
  166. Analysis of clinical characteristics in proximal and distal reflux monitoring among patients with gastroesophageal reflux disease
  167. Exosomal circ-0020887 and circ-0009590 as novel biomarkers for the diagnosis and prediction of short-term adverse cardiovascular outcomes in STEMI patients
  168. Upregulated microRNA-429 confers endometrial stromal cell dysfunction by targeting HIF1AN and regulating the HIF1A/VEGF pathway
  169. Bibliometrics and knowledge map analysis of ultrasound-guided regional anesthesia
  170. Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways
  171. D-dimer trends predict COVID-19 patient’s prognosis: A retrospective chart review study
  172. WTAP affects intracranial aneurysm progression by regulating m6A methylation modification
  173. Using of endoscopic polypectomy in patients with diagnosed malignant colorectal polyp – The cross-sectional clinical study
  174. Anti-S100A4 antibody administration alleviates bronchial epithelial–mesenchymal transition in asthmatic mice
  175. Prognostic evaluation of system immune-inflammatory index and prognostic nutritional index in double expressor diffuse large B-cell lymphoma
  176. Prevalence and antibiogram of bacteria causing urinary tract infection among patients with chronic kidney disease
  177. Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?
  178. Identification of disulfidptosis-related genes and immune infiltration in lower-grade glioma
  179. A new technique for uterine-preserving pelvic organ prolapse surgery: Laparoscopic rectus abdominis hysteropexy for uterine prolapse by comparing with traditional techniques
  180. Self-isolation of an Italian long-term care facility during COVID-19 pandemic: A comparison study on care-related infectious episodes
  181. A comparative study on the overlapping effects of clinically applicable therapeutic interventions in patients with central nervous system damage
  182. Low intensity extracorporeal shockwave therapy for chronic pelvic pain syndrome: Long-term follow-up
  183. The diagnostic accuracy of touch imprint cytology for sentinel lymph node metastases of breast cancer: An up-to-date meta-analysis of 4,073 patients
  184. Mortality associated with Sjögren’s syndrome in the United States in the 1999–2020 period: A multiple cause-of-death study
  185. CircMMP11 as a prognostic biomarker mediates miR-361-3p/HMGB1 axis to accelerate malignant progression of hepatocellular carcinoma
  186. Analysis of the clinical characteristics and prognosis of adult de novo acute myeloid leukemia (none APL) with PTPN11 mutations
  187. KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
  188. Evaluation of placental oxygenation by near-infrared spectroscopy in relation to ultrasound maturation grade in physiological term pregnancies
  189. The role of ultrasonographic findings for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2-negative breast cancer
  190. Construction of immunogenic cell death-related molecular subtypes and prognostic signature in colorectal cancer
  191. Long-term prognostic value of high-sensitivity cardiac troponin-I in patients with idiopathic dilated cardiomyopathy
  192. Establishing a novel Fanconi anemia signaling pathway-associated prognostic model and tumor clustering for pediatric acute myeloid leukemia patients
  193. Integrative bioinformatics analysis reveals STAT2 as a novel biomarker of inflammation-related cardiac dysfunction in atrial fibrillation
  194. Adipose-derived stem cells repair radiation-induced chronic lung injury via inhibiting TGF-β1/Smad 3 signaling pathway
  195. Real-world practice of idiopathic pulmonary fibrosis: Results from a 2000–2016 cohort
  196. lncRNA LENGA sponges miR-378 to promote myocardial fibrosis in atrial fibrillation
  197. Diagnostic value of urinary Tamm-Horsfall protein and 24 h urine osmolality for recurrent calcium oxalate stones of the upper urinary tract: Cross-sectional study
  198. The value of color Doppler ultrasonography combined with serum tumor markers in differential diagnosis of gastric stromal tumor and gastric cancer
  199. The spike protein of SARS-CoV-2 induces inflammation and EMT of lung epithelial cells and fibroblasts through the upregulation of GADD45A
  200. Mycophenolate mofetil versus cyclophosphamide plus in patients with connective tissue disease-associated interstitial lung disease: Efficacy and safety analysis
  201. MiR-1278 targets CALD1 and suppresses the progression of gastric cancer via the MAPK pathway
  202. Metabolomic analysis of serum short-chain fatty acid concentrations in a mouse of MPTP-induced Parkinson’s disease after dietary supplementation with branched-chain amino acids
  203. Cimifugin inhibits adipogenesis and TNF-α-induced insulin resistance in 3T3-L1 cells
  204. Predictors of gastrointestinal complaints in patients on metformin therapy
  205. Prescribing patterns in patients with chronic obstructive pulmonary disease and atrial fibrillation
  206. A retrospective analysis of the effect of latent tuberculosis infection on clinical pregnancy outcomes of in vitro fertilization–fresh embryo transferred in infertile women
  207. Appropriateness and clinical outcomes of short sustained low-efficiency dialysis: A national experience
  208. miR-29 regulates metabolism by inhibiting JNK-1 expression in non-obese patients with type 2 diabetes mellitus and NAFLD
  209. Clinical features and management of lymphoepithelial cyst
  210. Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia
  211. ENPP1 ameliorates vascular calcification via inhibiting the osteogenic transformation of VSMCs and generating PPi
  212. Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes
  213. The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study
  214. Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units
  215. Identification of diagnostic immune-related gene biomarkers for predicting heart failure after acute myocardial infarction
  216. Long-term administration of probiotics prevents gastrointestinal mucosal barrier dysfunction in septic mice partly by upregulating the 5-HT degradation pathway
  217. miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor
  218. Diagnostic and prognostic value of MR-pro ADM, procalcitonin, and copeptin in sepsis
  219. Review Articles
  220. Prenatal diagnosis of fetal defects and its implications on the delivery mode
  221. Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis
  222. Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
  223. Saddle pulmonary embolism in the setting of COVID-19 infection: A systematic review of case reports and case series
  224. Vitamin C and epigenetics: A short physiological overview
  225. Ebselen: A promising therapy protecting cardiomyocytes from excess iron in iron-overloaded thalassemia patients
  226. Aspirin versus LMWH for VTE prophylaxis after orthopedic surgery
  227. Mechanism of rhubarb in the treatment of hyperlipidemia: A recent review
  228. Surgical management and outcomes of traumatic global brachial plexus injury: A concise review and our center approach
  229. The progress of autoimmune hepatitis research and future challenges
  230. METTL16 in human diseases: What should we do next?
  231. New insights into the prevention of ureteral stents encrustation
  232. VISTA as a prospective immune checkpoint in gynecological malignant tumors: A review of the literature
  233. Case Reports
  234. Mycobacterium xenopi infection of the kidney and lymph nodes: A case report
  235. Genetic mutation of SLC6A20 (c.1072T > C) in a family with nephrolithiasis: A case report
  236. Chronic hepatitis B complicated with secondary hemochromatosis was cured clinically: A case report
  237. Liver abscess complicated with multiple organ invasive infection caused by hematogenous disseminated hypervirulent Klebsiella pneumoniae: A case report
  238. Urokinase-based lock solutions for catheter salvage: A case of an upcoming kidney transplant recipient
  239. Two case reports of maturity-onset diabetes of the young type 3 caused by the hepatocyte nuclear factor 1α gene mutation
  240. Immune checkpoint inhibitor-related pancreatitis: What is known and what is not
  241. Does total hip arthroplasty result in intercostal nerve injury? A case report and literature review
  242. Clinicopathological characteristics and diagnosis of hepatic sinusoidal obstruction syndrome caused by Tusanqi – Case report and literature review
  243. Synchronous triple primary gastrointestinal malignant tumors treated with laparoscopic surgery: A case report
  244. CT-guided percutaneous microwave ablation combined with bone cement injection for the treatment of transverse metastases: A case report
  245. Malignant hyperthermia: Report on a successful rescue of a case with the highest temperature of 44.2°C
  246. Anesthetic management of fetal pulmonary valvuloplasty: A case report
  247. Rapid Communication
  248. Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
  249. Erratum
  250. Erratum to “Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway”
  251. Erratum to: “Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p”
  252. Retraction
  253. Retraction of “Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients”
  254. Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
  255. Retraction of “miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells”
  256. Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”
  257. Retraction of “circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury”
  258. Retraction of “lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells”
  259. Special issue Linking Pathobiological Mechanisms to Clinical Application for cardiovascular diseases
  260. Effect of cardiac rehabilitation therapy on depressed patients with cardiac insufficiency after cardiac surgery
  261. Special issue The evolving saga of RNAs from bench to bedside - Part I
  262. FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma
  263. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part III
  264. Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer
https://doi.org/10.1515/med-2023-0738
Keywords for this article
lncRNA UCA1; atherosclerosis; miR-132; Lrrfip1; proliferation
Creative Commons
BY 4.0

Articles in the same Issue

  1. Research Articles
  2. Exosomes derived from mesenchymal stem cells overexpressing miR-210 inhibits neuronal inflammation and contribute to neurite outgrowth through modulating microglia polarization
  3. Current situation of acute ST-segment elevation myocardial infarction in a county hospital chest pain center during an epidemic of novel coronavirus pneumonia
  4. circ-IARS depletion inhibits the progression of non-small-cell lung cancer by circ-IARS/miR-1252-5p/HDGF ceRNA pathway
  5. circRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma
  6. WDR79 promotes aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) by the suppression of SIRT4
  7. Up-regulation of collagen type V alpha 2 (COL5A2) promotes malignant phenotypes in gastric cancer cell via inducing epithelial–mesenchymal transition (EMT)
  8. Inhibition of TERC inhibits neural apoptosis and inflammation in spinal cord injury through Akt activation and p-38 inhibition via the miR-34a-5p/XBP-1 axis
  9. 3D-printed polyether-ether-ketone/n-TiO2 composite enhances the cytocompatibility and osteogenic differentiation of MC3T3-E1 cells by downregulating miR-154-5p
  10. Propofol-mediated circ_0000735 downregulation restrains tumor growth by decreasing integrin-β1 expression in non-small cell lung cancer
  11. PVT1/miR-16/CCND1 axis regulates gastric cancer progression
  12. Silencing of circ_002136 sensitizes gastric cancer to paclitaxel by targeting the miR-16-5p/HMGA1 axis
  13. Short-term outcomes after simultaneous gastrectomy plus cholecystectomy in gastric cancer: A pooling up analysis
  14. SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways
  15. Molecular mechanism by which the Notch signaling pathway regulates autophagy in a rat model of pulmonary fibrosis in pigeon breeder’s lung
  16. lncRNA TPT1-AS1 promotes cell migration and invasion in esophageal squamous-cell carcinomas by regulating the miR-26a/HMGA1 axis
  17. SIRT1/APE1 promotes the viability of gastric cancer cells by inhibiting p53 to suppress ferroptosis
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  19. Treatments for brain metastases from EGFR/ALK-negative/unselected NSCLC: A network meta-analysis
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  21. circ_0000376 knockdown suppresses non-small cell lung cancer cell tumor properties by the miR-545-3p/PDPK1 pathway
  22. Delivery in a vertical birth chair supported by freedom of movement during labor: A randomized control trial
  23. UBE2J1 knockdown promotes cell apoptosis in endometrial cancer via regulating PI3K/AKT and MDM2/p53 signaling
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  30. circ_0014736 induces GPR4 to regulate the biological behaviors of human placental trophoblast cells through miR-942-5p in preeclampsia
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  40. Pyroptosis-based risk score predicts prognosis and drug sensitivity in lung adenocarcinoma
  41. Upregulation of lncRNA LANCL1-AS1 inhibits the progression of non-small-cell lung cancer via the miR-3680-3p/GMFG axis
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  43. Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS9
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  48. A novel long noncoding RNA AC125257.1 facilitates colorectal cancer progression by targeting miR-133a-3p/CASC5 axis
  49. Impact of omicron wave and associated control measures in Shanghai on health management and psychosocial well-being of patients with chronic conditions
  50. Clinicopathological characteristics and prognosis of young patients aged ≤45 years old with non-small cell lung cancer
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  53. miR-30b-5p targeting GRIN2A inhibits hippocampal damage in epilepsy
  54. Long non-coding RNA AL137789.1 promoted malignant biological behaviors and immune escape of pancreatic carcinoma cells
  55. IRF6 and FGF1 polymorphisms in non-syndromic cleft lip with or without cleft palate in the Polish population
  56. Comprehensive analysis of the role of SFXN family in breast cancer
  57. Efficacy of bronchoscopic intratumoral injection of endostar and cisplatin in lung squamous cell carcinoma patients underwent conventional chemoradiotherapy
  58. Silencing of long noncoding RNA MIAT inhibits the viability and proliferation of breast cancer cells by promoting miR-378a-5p expression
  59. AG1024, an IGF-1 receptor inhibitor, ameliorates renal injury in rats with diabetic nephropathy via the SOCS/JAK2/STAT pathway
  60. Downregulation of KIAA1199 alleviated the activation, proliferation, and migration of hepatic stellate cells by the inhibition of epithelial–mesenchymal transition
  61. Exendin-4 regulates the MAPK and WNT signaling pathways to alleviate the osteogenic inhibition of periodontal ligament stem cells in a high glucose environment
  62. Inhibition of glycolysis represses the growth and alleviates the endoplasmic reticulum stress of breast cancer cells by regulating TMTC3
  63. The function of lncRNA EMX2OS/miR-653-5p and its regulatory mechanism in lung adenocarcinoma
  64. Tectorigenin alleviates the apoptosis and inflammation in spinal cord injury cell model through inhibiting insulin-like growth factor-binding protein 6
  65. Ultrasound examination supporting CT or MRI in the evaluation of cervical lymphadenopathy in patients with irradiation-treated head and neck cancer
  66. F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway
  67. Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis
  68. Long noncoding RNA Mhrt alleviates angiotensin II-induced cardiac hypertrophy phenotypes by mediating the miR-765/Wnt family member 7B pathway
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  72. NECAB3 promotes the migration and invasion of liver cancer cells through HIF-1α/RIT1 signaling pathway
  73. The poor performance of cardiovascular risk scores in identifying patients with idiopathic inflammatory myopathies at high cardiovascular risk
  74. miR-2053 inhibits the growth of ovarian cancer cells by downregulating SOX4
  75. Nucleophosmin 1 associating with engulfment and cell motility protein 1 regulates hepatocellular carcinoma cell chemotaxis and metastasis
  76. α-Hederin regulates macrophage polarization to relieve sepsis-induced lung and liver injuries in mice
  77. Changes of microbiota level in urinary tract infections: A meta-analysis
  78. Identification of key enzalutamide-resistance-related genes in castration-resistant prostate cancer and verification of RAD51 functions
  79. Falls during oxaliplatin-based chemotherapy for gastrointestinal malignancies – (lessons learned from) a prospective study
  80. Outcomes of low-risk birth care during the Covid-19 pandemic: A cohort study from a tertiary care center in Lithuania
  81. Vitamin D protects intestines from liver cirrhosis-induced inflammation and oxidative stress by inhibiting the TLR4/MyD88/NF-κB signaling pathway
  82. Integrated transcriptome analysis identifies APPL1/RPS6KB2/GALK1 as immune-related metastasis factors in breast cancer
  83. Genomic analysis of immunogenic cell death-related subtypes for predicting prognosis and immunotherapy outcomes in glioblastoma multiforme
  84. Circular RNA Circ_0038467 promotes the maturation of miRNA-203 to increase lipopolysaccharide-induced apoptosis of chondrocytes
  85. An economic evaluation of fine-needle cytology as the primary diagnostic tool in the diagnosis of lymphadenopathy
  86. Midazolam impedes lung carcinoma cell proliferation and migration via EGFR/MEK/ERK signaling pathway
  87. Network pharmacology combined with molecular docking and experimental validation to reveal the pharmacological mechanism of naringin against renal fibrosis
  88. PTPN12 down-regulated by miR-146b-3p gene affects the malignant progression of laryngeal squamous cell carcinoma
  89. miR-141-3p accelerates ovarian cancer progression and promotes M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway
  90. lncRNA OIP5-AS1 attenuates the osteoarthritis progression in IL-1β-stimulated chondrocytes
  91. Overexpression of LINC00607 inhibits cell growth and aggressiveness by regulating the miR-1289/EFNA5 axis in non-small-cell lung cancer
  92. Subjective well-being in informal caregivers during the COVID-19 pandemic
  93. Nrf2 protects against myocardial ischemia-reperfusion injury in diabetic rats by inhibiting Drp1-mediated mitochondrial fission
  94. Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2B
  95. Bladder cancer screening: The new selection and prediction model
  96. circNFATC3 facilitated the progression of oral squamous cell carcinoma via the miR-520h/LDHA axis
  97. Prone position effect in intensive care patients with SARS-COV-2 pneumonia
  98. Clinical observation on the efficacy of Tongdu Tuina manipulation in the treatment of primary enuresis in children
  99. Dihydroartemisinin ameliorates cerebral I/R injury in rats via regulating VWF and autophagy-mediated SIRT1/FOXO1 pathway
  100. Knockdown of circ_0113656 assuages oxidized low-density lipoprotein-induced vascular smooth muscle cell injury through the miR-188-3p/IGF2 pathway
  101. Low Ang-(1–7) and high des-Arg9 bradykinin serum levels are correlated with cardiovascular risk factors in patients with COVID-19
  102. Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study
  103. Potential protective effects of Huanglian Jiedu Decoction against COVID-19-associated acute kidney injury: A network-based pharmacological and molecular docking study
  104. Clinical significance of serum MBD3 detection in girls with central precocious puberty
  105. Clinical features of varicella-zoster virus caused neurological diseases detected by metagenomic next-generation sequencing
  106. Collagen treatment of complex anorectal fistula: 3 years follow-up
  107. LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through down-regulating SP-A by sponging to miR-424
  108. Efficacy analysis of empirical bismuth quadruple therapy, high-dose dual therapy, and resistance gene-based triple therapy as a first-line Helicobacter pylori eradication regimen – An open-label, randomized trial
  109. SMOC2 plays a role in heart failure via regulating TGF-β1/Smad3 pathway-mediated autophagy
  110. A prospective cohort study of the impact of chronic disease on fall injuries in middle-aged and older adults
  111. circRNA THBS1 silencing inhibits the malignant biological behavior of cervical cancer cells via the regulation of miR-543/HMGB2 axis
  112. hsa_circ_0000285 sponging miR-582-3p promotes neuroblastoma progression by regulating the Wnt/β-catenin signaling pathway
  113. Long non-coding RNA GNAS-AS1 knockdown inhibits proliferation and epithelial–mesenchymal transition of lung adenocarcinoma cells via the microRNA-433-3p/Rab3A axis
  114. lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation
  115. Twenty-four-color full spectrum flow cytometry panel for minimal residual disease detection in acute myeloid leukemia
  116. Hsa-miR-223-3p participates in the process of anthracycline-induced cardiomyocyte damage by regulating NFIA gene
  117. Anti-inflammatory effect of ApoE23 on Salmonella typhimurium-induced sepsis in mice
  118. Analysis of somatic mutations and key driving factors of cervical cancer progression
  119. Hsa_circ_0028007 regulates the progression of nasopharyngeal carcinoma through the miR-1179/SQLE axis
  120. Variations in sexual function after laparoendoscopic single-site hysterectomy in women with benign gynecologic diseases
  121. Effects of pharmacological delay with roxadustat on multi-territory perforator flap survival in rats
  122. Analysis of heroin effects on calcium channels in rat cardiomyocytes based on transcriptomics and metabolomics
  123. Risk factors of recurrent bacterial vaginosis among women of reproductive age: A cross-sectional study
  124. Alkbh5 plays indispensable roles in maintaining self-renewal of hematopoietic stem cells
  125. Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients
  126. Correlation between microvessel maturity and ISUP grades assessed using contrast-enhanced transrectal ultrasonography in prostate cancer
  127. The protective effect of caffeic acid phenethyl ester in the nephrotoxicity induced by α-cypermethrin
  128. Norepinephrine alleviates cyclosporin A-induced nephrotoxicity by enhancing the expression of SFRP1
  129. Effect of RUNX1/FOXP3 axis on apoptosis of T and B lymphocytes and immunosuppression in sepsis
  130. The function of Foxp1 represses β-adrenergic receptor transcription in the occurrence and development of bladder cancer through STAT3 activity
  131. Risk model and validation of carbapenem-resistant Klebsiella pneumoniae infection in patients with cerebrovascular disease in the ICU
  132. Calycosin protects against chronic prostatitis in rats via inhibition of the p38MAPK/NF-κB pathway
  133. Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia
  134. The safety and immunogenicity to inactivated COVID-19 vaccine in patients with hyperlipemia
  135. Circ-UBR4 regulates the proliferation, migration, inflammation, and apoptosis in ox-LDL-induced vascular smooth muscle cells via miR-515-5p/IGF2 axis
  136. Clinical characteristics of current COVID-19 rehabilitation outpatients in China
  137. Luteolin alleviates ulcerative colitis in rats via regulating immune response, oxidative stress, and metabolic profiling
  138. miR-199a-5p inhibits aortic valve calcification by targeting ATF6 and GRP78 in valve interstitial cells
  139. The application of iliac fascia space block combined with esketamine intravenous general anesthesia in PFNA surgery of the elderly: A prospective, single-center, controlled trial
  140. Elevated blood acetoacetate levels reduce major adverse cardiac and cerebrovascular events risk in acute myocardial infarction
  141. The effects of progesterone on the healing of obstetric anal sphincter damage in female rats
  142. Identification of cuproptosis-related genes for predicting the development of prostate cancer
  143. Lumican silencing ameliorates β-glycerophosphate-mediated vascular smooth muscle cell calcification by attenuating the inhibition of APOB on KIF2C activity
  144. Targeting PTBP1 blocks glutamine metabolism to improve the cisplatin sensitivity of hepatocarcinoma cells through modulating the mRNA stability of glutaminase
  145. A single center prospective study: Influences of different hip flexion angles on the measurement of lumbar spine bone mineral density by dual energy X-ray absorptiometry
  146. Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis
  147. Antibiotics therapy combined with probiotics administered intravaginally for the treatment of bacterial vaginosis: A systematic review and meta-analysis
  148. Construction of a ceRNA network to reveal a vascular invasion associated prognostic model in hepatocellular carcinoma
  149. A pan-cancer analysis of STAT3 expression and genetic alterations in human tumors
  150. A prognostic signature based on seven T-cell-related cell clustering genes in bladder urothelial carcinoma
  151. Pepsin concentration in oral lavage fluid of rabbit reflux model constructed by dilating the lower esophageal sphincter
  152. The antihypertensive felodipine shows synergistic activity with immune checkpoint blockade and inhibits tumor growth via NFAT1 in LUSC
  153. Tanshinone IIA attenuates valvular interstitial cells’ calcification induced by oxidized low density lipoprotein via reducing endoplasmic reticulum stress
  154. AS-IV enhances the antitumor effects of propofol in NSCLC cells by inhibiting autophagy
  155. Establishment of two oxaliplatin-resistant gallbladder cancer cell lines and comprehensive analysis of dysregulated genes
  156. Trial protocol: Feasibility of neuromodulation with connectivity-guided intermittent theta-burst stimulation for improving cognition in multiple sclerosis
  157. LncRNA LINC00592 mediates the promoter methylation of WIF1 to promote the development of bladder cancer
  158. Factors associated with gastrointestinal dysmotility in critically ill patients
  159. Mechanisms by which spinal cord stimulation intervenes in atrial fibrillation: The involvement of the endothelin-1 and nerve growth factor/p75NTR pathways
  160. Analysis of two-gene signatures and related drugs in small-cell lung cancer by bioinformatics
  161. Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1
  162. Menstrual irregularities associated with COVID-19 vaccines among women in Saudi Arabia: A survey during 2022
  163. Ferroptosis involves in Schwann cell death in diabetic peripheral neuropathy
  164. The effect of AQP4 on tau protein aggregation in neurodegeneration and persistent neuroinflammation after cerebral microinfarcts
  165. Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin resistance
  166. Analysis of clinical characteristics in proximal and distal reflux monitoring among patients with gastroesophageal reflux disease
  167. Exosomal circ-0020887 and circ-0009590 as novel biomarkers for the diagnosis and prediction of short-term adverse cardiovascular outcomes in STEMI patients
  168. Upregulated microRNA-429 confers endometrial stromal cell dysfunction by targeting HIF1AN and regulating the HIF1A/VEGF pathway
  169. Bibliometrics and knowledge map analysis of ultrasound-guided regional anesthesia
  170. Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways
  171. D-dimer trends predict COVID-19 patient’s prognosis: A retrospective chart review study
  172. WTAP affects intracranial aneurysm progression by regulating m6A methylation modification
  173. Using of endoscopic polypectomy in patients with diagnosed malignant colorectal polyp – The cross-sectional clinical study
  174. Anti-S100A4 antibody administration alleviates bronchial epithelial–mesenchymal transition in asthmatic mice
  175. Prognostic evaluation of system immune-inflammatory index and prognostic nutritional index in double expressor diffuse large B-cell lymphoma
  176. Prevalence and antibiogram of bacteria causing urinary tract infection among patients with chronic kidney disease
  177. Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?
  178. Identification of disulfidptosis-related genes and immune infiltration in lower-grade glioma
  179. A new technique for uterine-preserving pelvic organ prolapse surgery: Laparoscopic rectus abdominis hysteropexy for uterine prolapse by comparing with traditional techniques
  180. Self-isolation of an Italian long-term care facility during COVID-19 pandemic: A comparison study on care-related infectious episodes
  181. A comparative study on the overlapping effects of clinically applicable therapeutic interventions in patients with central nervous system damage
  182. Low intensity extracorporeal shockwave therapy for chronic pelvic pain syndrome: Long-term follow-up
  183. The diagnostic accuracy of touch imprint cytology for sentinel lymph node metastases of breast cancer: An up-to-date meta-analysis of 4,073 patients
  184. Mortality associated with Sjögren’s syndrome in the United States in the 1999–2020 period: A multiple cause-of-death study
  185. CircMMP11 as a prognostic biomarker mediates miR-361-3p/HMGB1 axis to accelerate malignant progression of hepatocellular carcinoma
  186. Analysis of the clinical characteristics and prognosis of adult de novo acute myeloid leukemia (none APL) with PTPN11 mutations
  187. KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
  188. Evaluation of placental oxygenation by near-infrared spectroscopy in relation to ultrasound maturation grade in physiological term pregnancies
  189. The role of ultrasonographic findings for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2-negative breast cancer
  190. Construction of immunogenic cell death-related molecular subtypes and prognostic signature in colorectal cancer
  191. Long-term prognostic value of high-sensitivity cardiac troponin-I in patients with idiopathic dilated cardiomyopathy
  192. Establishing a novel Fanconi anemia signaling pathway-associated prognostic model and tumor clustering for pediatric acute myeloid leukemia patients
  193. Integrative bioinformatics analysis reveals STAT2 as a novel biomarker of inflammation-related cardiac dysfunction in atrial fibrillation
  194. Adipose-derived stem cells repair radiation-induced chronic lung injury via inhibiting TGF-β1/Smad 3 signaling pathway
  195. Real-world practice of idiopathic pulmonary fibrosis: Results from a 2000–2016 cohort
  196. lncRNA LENGA sponges miR-378 to promote myocardial fibrosis in atrial fibrillation
  197. Diagnostic value of urinary Tamm-Horsfall protein and 24 h urine osmolality for recurrent calcium oxalate stones of the upper urinary tract: Cross-sectional study
  198. The value of color Doppler ultrasonography combined with serum tumor markers in differential diagnosis of gastric stromal tumor and gastric cancer
  199. The spike protein of SARS-CoV-2 induces inflammation and EMT of lung epithelial cells and fibroblasts through the upregulation of GADD45A
  200. Mycophenolate mofetil versus cyclophosphamide plus in patients with connective tissue disease-associated interstitial lung disease: Efficacy and safety analysis
  201. MiR-1278 targets CALD1 and suppresses the progression of gastric cancer via the MAPK pathway
  202. Metabolomic analysis of serum short-chain fatty acid concentrations in a mouse of MPTP-induced Parkinson’s disease after dietary supplementation with branched-chain amino acids
  203. Cimifugin inhibits adipogenesis and TNF-α-induced insulin resistance in 3T3-L1 cells
  204. Predictors of gastrointestinal complaints in patients on metformin therapy
  205. Prescribing patterns in patients with chronic obstructive pulmonary disease and atrial fibrillation
  206. A retrospective analysis of the effect of latent tuberculosis infection on clinical pregnancy outcomes of in vitro fertilization–fresh embryo transferred in infertile women
  207. Appropriateness and clinical outcomes of short sustained low-efficiency dialysis: A national experience
  208. miR-29 regulates metabolism by inhibiting JNK-1 expression in non-obese patients with type 2 diabetes mellitus and NAFLD
  209. Clinical features and management of lymphoepithelial cyst
  210. Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia
  211. ENPP1 ameliorates vascular calcification via inhibiting the osteogenic transformation of VSMCs and generating PPi
  212. Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes
  213. The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study
  214. Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units
  215. Identification of diagnostic immune-related gene biomarkers for predicting heart failure after acute myocardial infarction
  216. Long-term administration of probiotics prevents gastrointestinal mucosal barrier dysfunction in septic mice partly by upregulating the 5-HT degradation pathway
  217. miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor
  218. Diagnostic and prognostic value of MR-pro ADM, procalcitonin, and copeptin in sepsis
  219. Review Articles
  220. Prenatal diagnosis of fetal defects and its implications on the delivery mode
  221. Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis
  222. Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
  223. Saddle pulmonary embolism in the setting of COVID-19 infection: A systematic review of case reports and case series
  224. Vitamin C and epigenetics: A short physiological overview
  225. Ebselen: A promising therapy protecting cardiomyocytes from excess iron in iron-overloaded thalassemia patients
  226. Aspirin versus LMWH for VTE prophylaxis after orthopedic surgery
  227. Mechanism of rhubarb in the treatment of hyperlipidemia: A recent review
  228. Surgical management and outcomes of traumatic global brachial plexus injury: A concise review and our center approach
  229. The progress of autoimmune hepatitis research and future challenges
  230. METTL16 in human diseases: What should we do next?
  231. New insights into the prevention of ureteral stents encrustation
  232. VISTA as a prospective immune checkpoint in gynecological malignant tumors: A review of the literature
  233. Case Reports
  234. Mycobacterium xenopi infection of the kidney and lymph nodes: A case report
  235. Genetic mutation of SLC6A20 (c.1072T > C) in a family with nephrolithiasis: A case report
  236. Chronic hepatitis B complicated with secondary hemochromatosis was cured clinically: A case report
  237. Liver abscess complicated with multiple organ invasive infection caused by hematogenous disseminated hypervirulent Klebsiella pneumoniae: A case report
  238. Urokinase-based lock solutions for catheter salvage: A case of an upcoming kidney transplant recipient
  239. Two case reports of maturity-onset diabetes of the young type 3 caused by the hepatocyte nuclear factor 1α gene mutation
  240. Immune checkpoint inhibitor-related pancreatitis: What is known and what is not
  241. Does total hip arthroplasty result in intercostal nerve injury? A case report and literature review
  242. Clinicopathological characteristics and diagnosis of hepatic sinusoidal obstruction syndrome caused by Tusanqi – Case report and literature review
  243. Synchronous triple primary gastrointestinal malignant tumors treated with laparoscopic surgery: A case report
  244. CT-guided percutaneous microwave ablation combined with bone cement injection for the treatment of transverse metastases: A case report
  245. Malignant hyperthermia: Report on a successful rescue of a case with the highest temperature of 44.2°C
  246. Anesthetic management of fetal pulmonary valvuloplasty: A case report
  247. Rapid Communication
  248. Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
  249. Erratum
  250. Erratum to “Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway”
  251. Erratum to: “Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p”
  252. Retraction
  253. Retraction of “Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients”
  254. Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
  255. Retraction of “miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells”
  256. Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”
  257. Retraction of “circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury”
  258. Retraction of “lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells”
  259. Special issue Linking Pathobiological Mechanisms to Clinical Application for cardiovascular diseases
  260. Effect of cardiac rehabilitation therapy on depressed patients with cardiac insufficiency after cardiac surgery
  261. Special issue The evolving saga of RNAs from bench to bedside - Part I
  262. FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma
  263. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part III
  264. Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer
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