Startseite Clinicopathological characteristics and prognosis of young patients aged ≤45 years old with non-small cell lung cancer
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Clinicopathological characteristics and prognosis of young patients aged ≤45 years old with non-small cell lung cancer

  • Jingjing Xia , Hong Li , Ruirui Zhang und Jipeng Wang EMAIL logo
Veröffentlicht/Copyright: 29. März 2023
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Open Medicine
Aus der Zeitschrift Open Medicine Band 18 Heft 1

Abstract

Lung cancer is rare in young people, but the incidence and mortality are on the rise. We retrospectively analyzed the data of young patients aged ≤45 years diagnosed as lung cancer in our hospital from 2014 to 2021. The purpose was to explore the clinicopathological characteristics of young patients, and the risk factors affecting overall survival (OS) time. The results showed that the young patients were mainly female, had no smoking history, asymptomatic at initial diagnosis, with a high proportion of adenocarcinoma and stage I–II. We divided all patients into two groups according to age and found that the proportion of stage I–II in 18–35 years group was significantly higher than that in 36–45 years group (P = 0.021). The main manifestation of tumor was ground glass opacity (GGO) in 18–35 years group, while most showed non-GGO in 36–45 years group (P = 0.003). The proportion of minimally invasive adenocarcinoma was higher in 18–35 years group, while the invasive adenocarcinoma was higher in 36–45 years group (P = 0.004). Univariate analysis showed that asymptomatic, stage I–II, surgery, women, with few or no metastatic organs had longer OS. Multivariate analysis showed that the independent factors affecting the OS of young patients were tumor stage and more metastatic organs.

Keywords: young patients; non-small cell lung cancer; clinicopathological characteristics; survival risk factors; prognosis

1 Introduction

Lung cancer is a very common malignant tumor in China, and it is also the primary cause of tumor-related death [1]. Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancer. Lung cancer mostly occurs in the elderly, and the median age of onset of lung cancer is 70 years old [2]. Young people with lung cancer are relatively rare, and NSCLC in young individuals with only <6% of all NSCLC patients being ≤45 years old [3]. There is a trend of increasing incidence of lung cancer among young adults in recent years [4,5], and the mortality rate also has an upward trend [6]. However, there are few studies on young patients with lung cancer. This study retrospectively analyzed 298 cases of NSCLC in young patients diagnosed in our hospital from 2014 to 2021, and explored the clinicopathological characteristics of young patients with lung cancer, the differences between different age subgroups, and risk factors affecting overall survival (OS).

2 Materials and methods

1. The clinical data of patients diagnosed with NSCLC aged 18–45 years in our hospital from January 2014 to December 2021 were retrospectively analyzed, with a total of 298 cases. All cases were confirmed by pathology. According to the latest classification of adenocarcinoma, carcinoma in situ was excluded [7]. Adenocarcinoma includes minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IA) in this study. Tumor staging was mainly based on the classification criteria of tumors, lymph nodes, and metastases (TNM) in the 8th editions of lung cancer. The following data were collected: gender, age, clinical feature, pathological type, TNM stage, lung CT manifestation, treatment, distant metastasis, etc. Around 276 patients were followed up until June 2022 or the date of death. This study was approved by the Ethic Committee of Huai’an First People’s Hospital (No. YW-2021-022-01).

2. All statistical analyses were performed using the SPSS19.0 software. Qualitative variables were described using counts and percent and compared by the Chi-square test. Kaplan–Meier method with log-rank tests were used for OS comparisons in univariate analysis. Multivariate analysis of survival was performed using the Cox proportional hazards regression to identify independent prognostic factors. The level of significance was set as 5%. The true effect of univariate analysis is easily covered by the influence of confounding factors, so we take the results of multivariate analysis as an independent risk factor affecting survival.

3 Results

3.1 Clinical characteristics of all young patients with NSCLC

A total of 298 young patients with lung cancer were included in the instant study, most of whom were female (65.1%) and had no smoking history (87.2%). The most common pathological type is adenocarcinoma (90.0%), including MIA (28.9%) and IA (61.1%). In addition, squamous cell carcinoma accounted for 4.7% and other types accounted for 5.3%. In terms of CT manifestations of tumors, 37.6% of cases showed as ground glass opacity (GGO), and non-GGO (solid nodule or mass or other) accounted for 62.4%. At the initial visit, most patients were asymptomatic (60.7%), 29.2% of them had cough/expectoration/sputum blood/asthma or fever, and other clinical symptoms were relatively rare. In respect of tumor staging, patients with stage I were the most (59.4%), followed by 71 patients with stage IV (23.8%), while patients with stage III and stage II accounted for 11.8 and 5.0%, respectively. Stage I–II was 192 (64.4%) in total, and stage III–IV was 106 (35.6%). Of all patients, 227 (76.2%) had no metastasis, 62 (20.8%) had 1–2 metastatic organs, and nine (3.0%) had three or more metastatic organs (Table 1). In 71 patients with stage IV, the most common distant metastasis site was bone (46.5%), followed by intrapulmonary (43.7%), pleural (29.6%), and brain (14.1%) (Table 2).

Table 1

Comparison of clinicopathological findings of the young patients with NSCLC between 18–35 years old group and 36–45 years old group

Total (n = 298) 18–35 years (n = 80) 36–45 years (n = 218) P
Gender
 Male 104 (34.9%) 27 (33.8%) 77 (35.3%)
 Female 194 (65.1%) 53 (66.2%) 141 (64.7%) 0.801
TNM stage
 I–II 192 (64.4%) 60 (75.0%) 132 (60.6%)
 III–IV 106 (35.6%) 20 (25.0%) 86 (39.4%) 0.021*
Surgery
 Yes 217 (72.8%) 60 (75.0%) 157 (72.0%)
 No 81 (27.2%) 20 (25.0%) 61 (28.0%) 0.608
Smoking history
 Yes 38 (12.8%) 12 (15.0 %) 26 (11.9%)
 No 260 (87.2%) 68 (85.0%) 192 (88.1%) 0.481
CT manifestations
 GGO 112 (37.6%) 41 (51.3%) 71 (32.6%)
 Non-GGO 186 (62.4%) 39 (48.7%) 147 (67.4%) 0.003*
Symptoms at diagnosis
 Asymptomatic 181 (60.7%) 55 (68.8%) 126 (57.8 %)
 Symptomatic 117 (39.3%) 25 (31.2%) 92 (42.2%) 0.086
Histologic type
 MIA 86 (28.9%) 34 (42.5%) 52 (23.9%)
 IA 182 (61.1%) 36 (45.0%) 146 (66.9%)
 SqCC 14 (4.7%) 4 (5.0%) 10 (4.6%)
 Other types 16 (5.3%) 6 (7.5%) 10 (4.6%) 0.004*
Number of distant metastatic organs
 0 227 (76.2%) 63 (78.8%) 164 (75.2%)
 1–2 62 (20.8%) 12 (15.0%) 50 (23.0%)
 ≥3 9 (3.0%) 5 (6.2%) 4 (1.8%) 0.059

MIA, minimally invasive adenocarcinoma; IA, invasive adenocarcinoma; SqCC, squamous cell carcinoma; other types, undifferentiated or other mixed NSCLC. *Indicates significant difference. P-value was the Chi-square test result of each factor between the two groups.

Table 2

Metastases of young patients at stage IV (n = 71)

Distant metastatic site Number Proportion (%)
Bone 33 46.5
Intrapulmonary 31 43.7
Pleura 21 29.6
Brain 10 14.1
Adrenal gland 7 9.9
Liver 6 8.5
Pericardium 5 7.0
Kidney 3 4.2
Pancreas 1 1.4
Muscle 1 1.4
Skin 1 1.4
Uterine appendage 1 1.4

3.2 Comparison of clinicopathological findings between 18–35 years old group and 36–45 years old group

We divided all patients into two groups according to age, 18–35 years old group and 36–45 years old group. The clinicopathological characteristics of the two groups were compared. The results revealed that there were statistical differences in TNM stage, pathological types, and lung CT manifestations of tumors between the two groups. The proportion of stage I–II in the 18–35 years old group was significantly higher than that in the 36–45 years old group (75.0% vs 60.6%, P = 0.003). There were statistical differences in the distribution of pathological types between the two groups (P = 0.004). Adenocarcinoma accounted for the most in both groups. However, the proportion of MIA in the 18–35 years old group was higher than that in the 36–45 years old group (42.5% vs 23.9%), while the proportion of IA in the 36–45 years old group was higher (66.9% vs 45.0%). Lung CT manifestation in the two groups had statistical difference (P = 0.003). The 18–35 years old group mainly showed GGO, while those in the 36–45 years old group mainly showed non-GGO. There was no significant difference between the two groups in gender, smoking history, surgery or not, the number of distant metastatic organs, and clinical manifestations at the initial diagnosis (Table 1).

3.3 Comparison of clinicopathological findings between 2014–2017 and 2018–2021

In order to study whether the characteristics of lung cancer in young patients have changed in recent years, we divided all patients into two groups for analysis according to the year of diagnosis: 2014–2017 and 2018–2021. We found that the proportion of patients in stage I–II (71.9% vs 41.9%), asymptomatic (70.5% vs 31.1%), MIA (37.9% vs 1.4%), GGO (48.2% vs 5.4%), and surgical treatment (78.1% vs 56.8%) during 2018–2021 was significantly higher than that in 2014–2017 (P < 0.05). The number of distant metastatic organs was significantly lower than that in the 2014–2017 group (P < 0.05) (Table 3).

Table 3

Comparison of clinicopathological findings of the young patients with NSCLC between 2014–2017 and 2018–2021

2014–2017 (n = 74) 2018–2021 (n = 224) P
Gender
 Male 29 (39.2%) 75 (33.5%)
 Female 45 (60.8%) 149 (66.5%) 0.372
TNM stage
 I–II 31 (41.9%) 161 (71.9%)
 III–IV 43 (58.1%) 63 (28.1%) <0.001*
Smoking history
 Yes 12 (16.2%) 26 (11.6%)
 No 62 (83.8%) 198 (88.4%) 0.303
Surgery
 Yes 42 (56.8%) 175 (78.1%)
 No 32 (43.2%) 49 (21.9%) <0.001*
Number of distant metastatic organs
 0 46 (62.2%) 181 (80.8%)
 1–2 24 (32.4%) 18 (8.0%)
 ≥3 4 (5.4%) 5 (2.2%) <0.001*
Histologic type
 MIA 1 (1.4%) 85 (37.9%)
 IA 59 (79.7%) 123 (54.9%)
 SqCC 8 (10.8%) 6 (2.7%)
 Other types 6 (8.1%) 10 (4.5%) <0.001*
CT manifestations
 GGO 4 (5.4%) 108 (48.2%)
 Non-GGO 70 (94.6%) 116 (51.8%) <0.001*
Symptoms at diagnosis
 Asymptomatic 23 (31.1%) 158 (70.5%)
 Symptomatic 51 (68.9%) 66 (29.5%) <0.001*

MIA, minimally invasive adenocarcinoma; IA, invasive adenocarcinoma; SqCC, squamous cell carcinoma; other types, undifferentiated or other mixed NSCLC. *Indicates significant difference. P-value was the Chi-square test result of each factor between the two groups.

3.4 Univariate and multivariate analysis of risk factors affecting OS

Among the 298 cases of NSCLC in this study, 276 cases were followed up. We used Kaplan–Meier method and log rank tests to draw the survival curve and conduct univariate analysis. Then Cox multivariate analysis was performed for statistically significant factors. We found that females had better prognosis than males (P = 0.046).Asymptomatic patients had longer OS than symptomatic patients (P < 0.001). Patients in stage I–II had better prognosis than stage III–IV (P < 0.001). Patients receiving surgery have had better prognosis than those without surgery (P < 0.001). Patients without distant metastasis or with 1–2 metastatic organs had longer OS than patients with metastatic organs ≥3 (P < 0.001). The survival curves are shown in Figure 1. There were no differences in smoking, age group (18–35 and 36–45 years), and pathology type (adenocarcinoma and non-adenocarcinoma). Cox multivariate analysis showed that the independent risk factors affecting OS of young patients were TNM stage (HR = 3.314, 95% CI 1.132–9.702, P = 0.029) and the number of distant metastatic organs (HR = 2.413, 95% CI 1.116–5.217, P = 0.025) (Table 4).

Figure 1 Survival curves in young patients of different groups: (a) different gender groups, (b) groups of symptomatic and asymptomatic, (c) groups of stage I–II and stage III–IV, (d) groups of different number of metastasis organs, (e) groups of surgery or not, and (f) groups of bone metastasis or not in stage IV patients.
Figure 1

Survival curves in young patients of different groups: (a) different gender groups, (b) groups of symptomatic and asymptomatic, (c) groups of stage I–II and stage III–IV, (d) groups of different number of metastasis organs, (e) groups of surgery or not, and (f) groups of bone metastasis or not in stage IV patients.

Table 4

Univariate and multivariate analysis for risk factors of OS in young patients with NSCLC

Univariate analysis Multivariate analysis
χ 2 # P HR 95% CI ## P
TNM stage 73.805 <0.001* 3.314 1.132–9.702 0.029*
 I–II
 III–IV
Number of distant metastatic organs 121.820 <0.001* 2.413 1.116–5.217 0.025*
 0
 1–2
 ≥3
Gender 3.997 0.046* 0.743 0.424–1.300 0.298
 Male
 Female
Symptoms at diagnosis 51.353 <0.001* 0.392 0.133–1.155 0.089
 Symptomatic
 Asymptomatic
Surgery 79.932 <0.001* 1.137 0.410–3.155 0.805
 Yes
 No
Age 2.155 0.142 — — —
 18–35 years
 36–45 years
Adenocarcinoma or not 1.25 0.264 — — —
 Yes
 No
Smoking history 0.393 0.531 — — —
 Yes
 No

# P-value was the result of univariate analysis. ## P was the result of multivariate analysis. *Indicates significant difference. HR, hazard ratio; CI, confidence interval.

3.5 Survival analysis of stage IV patients with bone metastasis or not

There were 71 patients with stage IV in this study. The most common distant metastasis site is bone (46.5%), followed by intrapulmonary (43.7%), pleural (29.6%), and brain (14.1%) (Table 2). Patients with stage IV were divided into two groups according to whether there was bone metastasis, the results showed that there was no statistical difference in OS between the two groups, P = 0.289 (Figure 1).

4 Discussion

Recent studies show that occupations with high exposure risk, smoking, and family history of lung cancer are risk factors for lung cancer in young people [8,9]. Young patients with lung cancer have unique clinicopathological and gene mutation characteristics, such as common in women, no smoking history, mainly adenocarcinoma, with advanced TNM stage, and prevalence of targeted genetic alterations such as ALK gene and EGFR gene mutations. The prognosis of young patient with lung cancer is often poor, but these views are controversial [6,8,10–17]. This situation may be related to different research objects and age cut-off, or it may be related to different races of the population. For example, some studies choose all young patients with lung cancer, while others chose only NSCLC or adenocarcinoma in young adults. The age cut-off selected ranged from 40 to 50 years old. These differences will lead to different results. Young people under the age of 45 years old have distinctive genetic profile [18], which can be used as the age cut-off for young people with lung adenocarcinoma. Therefore, we used 45 years old as the age cut-off for young people with lung cancer in this study.

This study showed that females are in the majority, mainly adenocarcinoma (90.0%), and most patients have no smoking history, which is consistent with many literature reports [6,11,12]. The smoking rate of young people with lung cancer in this study is very low (12.8%), far lower than the literature report [19]. This may be related to the national tobacco control and the improvement of young people’s awareness about the harmful effects of tobacco, and the smoking rate of Chinese women is not high. But this proportion is basically consistent with another study, i.e., the smoking rate in lung cancer patients aged below 40 years old was 14.4% [2]. Although many young women have no smoking history, the high incidence of lung cancer may be related to inhalation of kitchen oil smoke or second-hand smoke [20]. Of course, the reasons in genomics await further in-depth research.

In terms of tumor stage, this study shows that young patients with lung cancer in stage I–II is more common (64.4%), and stage III–IV only accounts for 35.6%, which is different from other literatures that young patients are mainly in advanced stage [8]. We consider that this is related to the detection of many MIA in young adults in recent years. It can be seen from the grouping of diagnosis years that many MIA in the form of GGO were found from 2008 to 2021 (Table 3). Especially since the COVID-19 epidemic at the end of 2019, many asymptomatic young people underwent chest CT examination and screened a large number of GGO in the lung. Most of these lung cancers with GGO are MIA or early stage IA, which has led to an increase in the proportion of stage I–II patients in recent years.

There were statistical differences between the two groups (18–35 years old group and 36–45 years old group) in TNM stage, pathological type, and CT manifestation of the tumor. Compared with the 36–45 years old group, there are more patients with stage I–II and the tumors mainly showed as GGO in the 18–35 years old group. Although adenocarcinoma accounted for the most in both the groups, the proportion of MIA in the 18–35 years old group was relatively higher than in 36–45 years old group (42.5% vs 23.9%), while the proportion of IA in the 36–45 years old group was relatively higher (66.9% vs 45.0%). There was no significant difference between the two groups in gender, smoking history, surgery or not, the number of distant metastatic organs, and clinical manifestations. Therefore, we believe that patients in the 18–35 years old group had unique clinicopathological characteristics, including that lung lesions were more manifested as GGO, with early stage at the initial diagnosis, and the pathological type was mainly MIA.

Among 71 patients with stage IV, the most common metastasis site was bone (46.5%), followed by intrapulmonary (43.7%), pleural (29.6%), and brain (14.1%).The results were similar to one study on young patients with NSCLC [16], which shows the sites of metastases: bone (43%), intrapulmonary lesions (37%), pleura (30%), and brain (21%) metastases were the four most common metastases. Studies have shown that the survival time of lung cancer with bone metastasis is shorter than that of other metastasis sites [21,22]. We divided patients with stage IV into two groups according to whether there was bone metastasis and compared the OS time, but the results showed that there was no statistical difference between the two groups. The effect of bone metastasis on the prognosis of young patients with lung cancer in this study is inconsistent with the above literature, which may have three reasons. First, different sites and numbers of bone metastases have different effects on prognosis [23]. Second, the subjects of previous literature were all lung cancer patients without age limit, while this study was mainly aimed at young patients with lung cancer. Third, the small sample size of a single center may also have a certain impact on the results.

There were few relevant studies on the prognosis of young patients with lung cancer, and the obtained results have been controversial. A study [6] shows that a family history of cancer, symptoms at diagnosis, pathology, stage at diagnosis, and surgery were confirmed as independent prognostic factors in younger lung cancer patients. In another article published in 2017, 420 young patients with lung cancer from two Chinese hospitals from 2000 to 2003 were analyzed. Multivariate analysis did not show that pathological type was an independent risk factor affecting the survival of young patients with lung cancer [8]. In yet another US study, it was shown that male sex and non-adenocarcinoma histology were independent negative prognostic factors among the young. Moreover, compared with the total population, African Americans was a poor prognostic factor for young people [24]. Due to the limited number of samples in this group and the small number of patients with squamous cell carcinoma, we divided all young NSCLC into adenocarcinoma and non-adenocarcinoma groups, and there was no significant difference in survival time between the two groups. The inconsistency of these results may be related to the race of the subjects and the limited small sample size. Therefore, the influence of pathological types on the prognosis of young patients with lung cancer needs more research to verify.

The univariate analysis of this study shows that females, asymptomatic patients, and those who underwent surgery had longer survival time in young patients with lung cancer (P < 0.05), which is consistent with literature report [6]. In addition, the univariate analysis of this study shows that TNM stage and the number of distant metastatic organs are also important factors affecting OS of young patients with lung cancer. We included gender, surgery or not, TNM stage, the number of distant metastatic organs, and symptoms into Cox multifactor analysis, and finally concluded that the independent risk factors affecting OS of young patients with NSCLC were TNM stage (HR = 3.314, 95% CI 1.132–9.702, P = 0.029) and the number of distant metastatic organs (HR = 2.413, 95% CI 1.116–5.217, P = 0.025).

Smoking is a well-known risk factor that causes lung cancer and affects the prognosis of patients, but the results of this study show that the prognosis of young patients with lung cancer is not related to smoking history. This is confusing. However, in recent years, many reports show that young patients with lung cancer is mostly female and has no smoking history, so the natural development process of lung cancer in young patients cannot be completely explained by smoking. There may be other unknown reasons, such as genomic mutations, which need further research. This may also be related to the fact that many patients smoke passively or inhale more lampblack without enough attention, and the small sample size of a single center.

There are few literature on the impact of age on OS in young patients with lung cancer. All patients were divided into 18–35 years old group and 36–45 years old group due to the limitation of sample size in this study, and univariate analysis showed that there was no statistical difference in OS between the two groups. Therefore, whether the OS of young patients under 45 years old with NSCLC is affected by age needs further study.

This study also has some shortcomings: small sample size of a single center, lack of some other important factors collected, such as gene mutation, family history, etc. Young people are the backbone of the country and shoulder multiple responsibilities for family and society. Enough attention should be paid to young people in the face of the increasing incidence and mortality in young patients with lung cancer. However, there are few studies on young patients with lung cancer at present, especially on the risk factors affecting the survival time. This study can provide reference for more studies in the future, and also give some enlightenment to clinical work. Most young patients have no clinical symptoms at the first diagnosis. Recognizing the clinicopathological characteristics of young patients with lung cancer can reduce misdiagnosis and avoid late diagnosis. In addition, a large number of GGO have been detected in asymptomatic people in recent years, and most of them are MIA or early stage IA [25,26]. Adenocarcinoma with GGO has a good prognosis [27,28]. In our study, the CT findings of young patients with NSCLC in 2018–2021 group were mainly GGO, while the lung lesions of young patients diagnosed in 2014–2017 were mostly non-GGO. The patients in the 18–35 years old group were more likely to show GGO than those in the 36–45 years old group. Therefore, we believe that young patients with NSCLC tend to have GGO as the main CT manifestations in recent years. If this part of patients with early stage can be screened out and treated surgically, then these patients will have a very good prognosis and survival. At present, the recommended screening age for lung cancer in China is 50 years old. It is worth considering whether low-dose chest CT screening can be carried out in young people aged below 45 years, like once every 2–3 years. The purpose is to detect and treat young patients with lung cancer in the early stage, prolong survival time, and reduce the pain of individuals and families and the burden of the country caused by advanced lung cancer.

5 Conclusion

From 2018 to 2021, there were many asymptomatic young patients with NSCLC with stage I–II in the form of GGO. Among all young patients, most are females, with no smoking history, have no symptoms at the first diagnosis, mainly adenocarcinoma, and with stage I–II. Compared with the 36–45 years old group, patients in the 18–35 years old group have unique clinicopathological characteristics. The proportion of stage I–II in the 18–35 years old group is significantly higher than that in the 36–45 years old group. Lung cancer mainly manifested as GGO in the 18–35 years old group, while most of the lesions were non-GGO (solid nodules, masses, or other) in 36–45 years old group. Adenocarcinoma accounted for the most in both the groups, but the proportion of MIA in the 18–35 years old group was relatively higher than in 36–45 years old group, while the proportion of IA in the 36–45 years old group was relatively higher. The independent risk factors affecting the OS of young patients with NSCLC are TNM stage and the number of distant metastatic organs. There was no statistical difference in terms of OS whether there was bone metastasis in stage IV patients.

Acknowledgements

We thank all our colleagues and authors in our hospital for their assistance.

  1. Funding information: There was no financial support in this study.

  2. Conflict of interest: The authors declare no conflict of interest.

  3. Data availability statement: The data are available from the corresponding author on reasonable request.

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Received: 2022-10-08
Revised: 2023-02-20
Accepted: 2023-03-02
Published Online: 2023-03-29

© 2023 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Artikel in diesem Heft

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  217. miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor
  218. Diagnostic and prognostic value of MR-pro ADM, procalcitonin, and copeptin in sepsis
  219. Review Articles
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  233. Case Reports
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  236. Chronic hepatitis B complicated with secondary hemochromatosis was cured clinically: A case report
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  241. Does total hip arthroplasty result in intercostal nerve injury? A case report and literature review
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  247. Rapid Communication
  248. Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
  249. Erratum
  250. Erratum to “Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway”
  251. Erratum to: “Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p”
  252. Retraction
  253. Retraction of “Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients”
  254. Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
  255. Retraction of “miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells”
  256. Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”
  257. Retraction of “circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury”
  258. Retraction of “lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells”
  259. Special issue Linking Pathobiological Mechanisms to Clinical Application for cardiovascular diseases
  260. Effect of cardiac rehabilitation therapy on depressed patients with cardiac insufficiency after cardiac surgery
  261. Special issue The evolving saga of RNAs from bench to bedside - Part I
  262. FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma
  263. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part III
  264. Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer
https://doi.org/10.1515/med-2023-0684
Schlagwörter für diesen Artikel
young patients; non-small cell lung cancer; clinicopathological characteristics; survival risk factors; prognosis
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Artikel in diesem Heft

  1. Research Articles
  2. Exosomes derived from mesenchymal stem cells overexpressing miR-210 inhibits neuronal inflammation and contribute to neurite outgrowth through modulating microglia polarization
  3. Current situation of acute ST-segment elevation myocardial infarction in a county hospital chest pain center during an epidemic of novel coronavirus pneumonia
  4. circ-IARS depletion inhibits the progression of non-small-cell lung cancer by circ-IARS/miR-1252-5p/HDGF ceRNA pathway
  5. circRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma
  6. WDR79 promotes aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) by the suppression of SIRT4
  7. Up-regulation of collagen type V alpha 2 (COL5A2) promotes malignant phenotypes in gastric cancer cell via inducing epithelial–mesenchymal transition (EMT)
  8. Inhibition of TERC inhibits neural apoptosis and inflammation in spinal cord injury through Akt activation and p-38 inhibition via the miR-34a-5p/XBP-1 axis
  9. 3D-printed polyether-ether-ketone/n-TiO2 composite enhances the cytocompatibility and osteogenic differentiation of MC3T3-E1 cells by downregulating miR-154-5p
  10. Propofol-mediated circ_0000735 downregulation restrains tumor growth by decreasing integrin-β1 expression in non-small cell lung cancer
  11. PVT1/miR-16/CCND1 axis regulates gastric cancer progression
  12. Silencing of circ_002136 sensitizes gastric cancer to paclitaxel by targeting the miR-16-5p/HMGA1 axis
  13. Short-term outcomes after simultaneous gastrectomy plus cholecystectomy in gastric cancer: A pooling up analysis
  14. SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways
  15. Molecular mechanism by which the Notch signaling pathway regulates autophagy in a rat model of pulmonary fibrosis in pigeon breeder’s lung
  16. lncRNA TPT1-AS1 promotes cell migration and invasion in esophageal squamous-cell carcinomas by regulating the miR-26a/HMGA1 axis
  17. SIRT1/APE1 promotes the viability of gastric cancer cells by inhibiting p53 to suppress ferroptosis
  18. Glycoprotein non-metastatic melanoma B interacts with epidermal growth factor receptor to regulate neural stem cell survival and differentiation
  19. Treatments for brain metastases from EGFR/ALK-negative/unselected NSCLC: A network meta-analysis
  20. Association of osteoporosis and skeletal muscle loss with serum type I collagen carboxyl-terminal peptide β glypeptide: A cross-sectional study in elder Chinese population
  21. circ_0000376 knockdown suppresses non-small cell lung cancer cell tumor properties by the miR-545-3p/PDPK1 pathway
  22. Delivery in a vertical birth chair supported by freedom of movement during labor: A randomized control trial
  23. UBE2J1 knockdown promotes cell apoptosis in endometrial cancer via regulating PI3K/AKT and MDM2/p53 signaling
  24. Metabolic resuscitation therapy in critically ill patients with sepsis and septic shock: A pilot prospective randomized controlled trial
  25. Lycopene ameliorates locomotor activity and urinary frequency induced by pelvic venous congestion in rats
  26. UHRF1-induced connexin26 methylation is involved in hearing damage triggered by intermittent hypoxia in neonatal rats
  27. LINC00511 promotes melanoma progression by targeting miR-610/NUCB2
  28. Ultra-high-performance liquid chromatography-tandem mass spectrometry analysis of serum metabolomic characteristics in people with different vitamin D levels
  29. Role of Jumonji domain-containing protein D3 and its inhibitor GSK-J4 in Hashimoto’s thyroiditis
  30. circ_0014736 induces GPR4 to regulate the biological behaviors of human placental trophoblast cells through miR-942-5p in preeclampsia
  31. Monitoring of sirolimus in the whole blood samples from pediatric patients with lymphatic anomalies
  32. Effects of osteogenic growth peptide C-terminal pentapeptide and its analogue on bone remodeling in an osteoporosis rat model
  33. A novel autophagy-related long non-coding RNAs signature predicting progression-free interval and I-131 therapy benefits in papillary thyroid carcinoma
  34. WGCNA-based identification of potential targets and pathways in response to treatment in locally advanced breast cancer patients
  35. Radiomics model using preoperative computed tomography angiography images to differentiate new from old emboli of acute lower limb arterial embolism
  36. Dysregulated lncRNAs are involved in the progress of myocardial infarction by constructing regulatory networks
  37. Single-arm trial to evaluate the efficacy and safety of baclofen in treatment of intractable hiccup caused by malignant tumor chemotherapy
  38. Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk
  39. Efficacy of immune checkpoint inhibitors in patients with KRAS-mutant advanced non-small cell lung cancer: A retrospective analysis
  40. Pyroptosis-based risk score predicts prognosis and drug sensitivity in lung adenocarcinoma
  41. Upregulation of lncRNA LANCL1-AS1 inhibits the progression of non-small-cell lung cancer via the miR-3680-3p/GMFG axis
  42. CircRANBP17 modulated KDM1A to regulate neuroblastoma progression by sponging miR-27b-3p
  43. Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS9
  44. Downregulation of RBM17 enhances cisplatin sensitivity and inhibits cell invasion in human hypopharyngeal cancer cells
  45. HDAC5-mediated PRAME regulates the proliferation, migration, invasion, and EMT of laryngeal squamous cell carcinoma via the PI3K/AKT/mTOR signaling pathway
  46. The association between sleep duration, quality, and nonalcoholic fatty liver disease: A cross-sectional study
  47. Myostatin silencing inhibits podocyte apoptosis in membranous nephropathy through Smad3/PKA/NOX4 signaling pathway
  48. A novel long noncoding RNA AC125257.1 facilitates colorectal cancer progression by targeting miR-133a-3p/CASC5 axis
  49. Impact of omicron wave and associated control measures in Shanghai on health management and psychosocial well-being of patients with chronic conditions
  50. Clinicopathological characteristics and prognosis of young patients aged ≤45 years old with non-small cell lung cancer
  51. TMT-based comprehensive proteomic profiling identifies serum prognostic signatures of acute myeloid leukemia
  52. The dose limits of teeth protection for patients with nasopharyngeal carcinoma undergoing radiotherapy based on the early oral health-related quality of life
  53. miR-30b-5p targeting GRIN2A inhibits hippocampal damage in epilepsy
  54. Long non-coding RNA AL137789.1 promoted malignant biological behaviors and immune escape of pancreatic carcinoma cells
  55. IRF6 and FGF1 polymorphisms in non-syndromic cleft lip with or without cleft palate in the Polish population
  56. Comprehensive analysis of the role of SFXN family in breast cancer
  57. Efficacy of bronchoscopic intratumoral injection of endostar and cisplatin in lung squamous cell carcinoma patients underwent conventional chemoradiotherapy
  58. Silencing of long noncoding RNA MIAT inhibits the viability and proliferation of breast cancer cells by promoting miR-378a-5p expression
  59. AG1024, an IGF-1 receptor inhibitor, ameliorates renal injury in rats with diabetic nephropathy via the SOCS/JAK2/STAT pathway
  60. Downregulation of KIAA1199 alleviated the activation, proliferation, and migration of hepatic stellate cells by the inhibition of epithelial–mesenchymal transition
  61. Exendin-4 regulates the MAPK and WNT signaling pathways to alleviate the osteogenic inhibition of periodontal ligament stem cells in a high glucose environment
  62. Inhibition of glycolysis represses the growth and alleviates the endoplasmic reticulum stress of breast cancer cells by regulating TMTC3
  63. The function of lncRNA EMX2OS/miR-653-5p and its regulatory mechanism in lung adenocarcinoma
  64. Tectorigenin alleviates the apoptosis and inflammation in spinal cord injury cell model through inhibiting insulin-like growth factor-binding protein 6
  65. Ultrasound examination supporting CT or MRI in the evaluation of cervical lymphadenopathy in patients with irradiation-treated head and neck cancer
  66. F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway
  67. Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis
  68. Long noncoding RNA Mhrt alleviates angiotensin II-induced cardiac hypertrophy phenotypes by mediating the miR-765/Wnt family member 7B pathway
  69. Effect of miR-499-5p/SOX6 axis on atrial fibrosis in rats with atrial fibrillation
  70. Cholesterol induces inflammation and reduces glucose utilization
  71. circ_0004904 regulates the trophoblast cell in preeclampsia via miR-19b-3p/ARRDC3 axis
  72. NECAB3 promotes the migration and invasion of liver cancer cells through HIF-1α/RIT1 signaling pathway
  73. The poor performance of cardiovascular risk scores in identifying patients with idiopathic inflammatory myopathies at high cardiovascular risk
  74. miR-2053 inhibits the growth of ovarian cancer cells by downregulating SOX4
  75. Nucleophosmin 1 associating with engulfment and cell motility protein 1 regulates hepatocellular carcinoma cell chemotaxis and metastasis
  76. α-Hederin regulates macrophage polarization to relieve sepsis-induced lung and liver injuries in mice
  77. Changes of microbiota level in urinary tract infections: A meta-analysis
  78. Identification of key enzalutamide-resistance-related genes in castration-resistant prostate cancer and verification of RAD51 functions
  79. Falls during oxaliplatin-based chemotherapy for gastrointestinal malignancies – (lessons learned from) a prospective study
  80. Outcomes of low-risk birth care during the Covid-19 pandemic: A cohort study from a tertiary care center in Lithuania
  81. Vitamin D protects intestines from liver cirrhosis-induced inflammation and oxidative stress by inhibiting the TLR4/MyD88/NF-κB signaling pathway
  82. Integrated transcriptome analysis identifies APPL1/RPS6KB2/GALK1 as immune-related metastasis factors in breast cancer
  83. Genomic analysis of immunogenic cell death-related subtypes for predicting prognosis and immunotherapy outcomes in glioblastoma multiforme
  84. Circular RNA Circ_0038467 promotes the maturation of miRNA-203 to increase lipopolysaccharide-induced apoptosis of chondrocytes
  85. An economic evaluation of fine-needle cytology as the primary diagnostic tool in the diagnosis of lymphadenopathy
  86. Midazolam impedes lung carcinoma cell proliferation and migration via EGFR/MEK/ERK signaling pathway
  87. Network pharmacology combined with molecular docking and experimental validation to reveal the pharmacological mechanism of naringin against renal fibrosis
  88. PTPN12 down-regulated by miR-146b-3p gene affects the malignant progression of laryngeal squamous cell carcinoma
  89. miR-141-3p accelerates ovarian cancer progression and promotes M2-like macrophage polarization by targeting the Keap1-Nrf2 pathway
  90. lncRNA OIP5-AS1 attenuates the osteoarthritis progression in IL-1β-stimulated chondrocytes
  91. Overexpression of LINC00607 inhibits cell growth and aggressiveness by regulating the miR-1289/EFNA5 axis in non-small-cell lung cancer
  92. Subjective well-being in informal caregivers during the COVID-19 pandemic
  93. Nrf2 protects against myocardial ischemia-reperfusion injury in diabetic rats by inhibiting Drp1-mediated mitochondrial fission
  94. Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2B
  95. Bladder cancer screening: The new selection and prediction model
  96. circNFATC3 facilitated the progression of oral squamous cell carcinoma via the miR-520h/LDHA axis
  97. Prone position effect in intensive care patients with SARS-COV-2 pneumonia
  98. Clinical observation on the efficacy of Tongdu Tuina manipulation in the treatment of primary enuresis in children
  99. Dihydroartemisinin ameliorates cerebral I/R injury in rats via regulating VWF and autophagy-mediated SIRT1/FOXO1 pathway
  100. Knockdown of circ_0113656 assuages oxidized low-density lipoprotein-induced vascular smooth muscle cell injury through the miR-188-3p/IGF2 pathway
  101. Low Ang-(1–7) and high des-Arg9 bradykinin serum levels are correlated with cardiovascular risk factors in patients with COVID-19
  102. Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study
  103. Potential protective effects of Huanglian Jiedu Decoction against COVID-19-associated acute kidney injury: A network-based pharmacological and molecular docking study
  104. Clinical significance of serum MBD3 detection in girls with central precocious puberty
  105. Clinical features of varicella-zoster virus caused neurological diseases detected by metagenomic next-generation sequencing
  106. Collagen treatment of complex anorectal fistula: 3 years follow-up
  107. LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through down-regulating SP-A by sponging to miR-424
  108. Efficacy analysis of empirical bismuth quadruple therapy, high-dose dual therapy, and resistance gene-based triple therapy as a first-line Helicobacter pylori eradication regimen – An open-label, randomized trial
  109. SMOC2 plays a role in heart failure via regulating TGF-β1/Smad3 pathway-mediated autophagy
  110. A prospective cohort study of the impact of chronic disease on fall injuries in middle-aged and older adults
  111. circRNA THBS1 silencing inhibits the malignant biological behavior of cervical cancer cells via the regulation of miR-543/HMGB2 axis
  112. hsa_circ_0000285 sponging miR-582-3p promotes neuroblastoma progression by regulating the Wnt/β-catenin signaling pathway
  113. Long non-coding RNA GNAS-AS1 knockdown inhibits proliferation and epithelial–mesenchymal transition of lung adenocarcinoma cells via the microRNA-433-3p/Rab3A axis
  114. lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation
  115. Twenty-four-color full spectrum flow cytometry panel for minimal residual disease detection in acute myeloid leukemia
  116. Hsa-miR-223-3p participates in the process of anthracycline-induced cardiomyocyte damage by regulating NFIA gene
  117. Anti-inflammatory effect of ApoE23 on Salmonella typhimurium-induced sepsis in mice
  118. Analysis of somatic mutations and key driving factors of cervical cancer progression
  119. Hsa_circ_0028007 regulates the progression of nasopharyngeal carcinoma through the miR-1179/SQLE axis
  120. Variations in sexual function after laparoendoscopic single-site hysterectomy in women with benign gynecologic diseases
  121. Effects of pharmacological delay with roxadustat on multi-territory perforator flap survival in rats
  122. Analysis of heroin effects on calcium channels in rat cardiomyocytes based on transcriptomics and metabolomics
  123. Risk factors of recurrent bacterial vaginosis among women of reproductive age: A cross-sectional study
  124. Alkbh5 plays indispensable roles in maintaining self-renewal of hematopoietic stem cells
  125. Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients
  126. Correlation between microvessel maturity and ISUP grades assessed using contrast-enhanced transrectal ultrasonography in prostate cancer
  127. The protective effect of caffeic acid phenethyl ester in the nephrotoxicity induced by α-cypermethrin
  128. Norepinephrine alleviates cyclosporin A-induced nephrotoxicity by enhancing the expression of SFRP1
  129. Effect of RUNX1/FOXP3 axis on apoptosis of T and B lymphocytes and immunosuppression in sepsis
  130. The function of Foxp1 represses β-adrenergic receptor transcription in the occurrence and development of bladder cancer through STAT3 activity
  131. Risk model and validation of carbapenem-resistant Klebsiella pneumoniae infection in patients with cerebrovascular disease in the ICU
  132. Calycosin protects against chronic prostatitis in rats via inhibition of the p38MAPK/NF-κB pathway
  133. Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia
  134. The safety and immunogenicity to inactivated COVID-19 vaccine in patients with hyperlipemia
  135. Circ-UBR4 regulates the proliferation, migration, inflammation, and apoptosis in ox-LDL-induced vascular smooth muscle cells via miR-515-5p/IGF2 axis
  136. Clinical characteristics of current COVID-19 rehabilitation outpatients in China
  137. Luteolin alleviates ulcerative colitis in rats via regulating immune response, oxidative stress, and metabolic profiling
  138. miR-199a-5p inhibits aortic valve calcification by targeting ATF6 and GRP78 in valve interstitial cells
  139. The application of iliac fascia space block combined with esketamine intravenous general anesthesia in PFNA surgery of the elderly: A prospective, single-center, controlled trial
  140. Elevated blood acetoacetate levels reduce major adverse cardiac and cerebrovascular events risk in acute myocardial infarction
  141. The effects of progesterone on the healing of obstetric anal sphincter damage in female rats
  142. Identification of cuproptosis-related genes for predicting the development of prostate cancer
  143. Lumican silencing ameliorates β-glycerophosphate-mediated vascular smooth muscle cell calcification by attenuating the inhibition of APOB on KIF2C activity
  144. Targeting PTBP1 blocks glutamine metabolism to improve the cisplatin sensitivity of hepatocarcinoma cells through modulating the mRNA stability of glutaminase
  145. A single center prospective study: Influences of different hip flexion angles on the measurement of lumbar spine bone mineral density by dual energy X-ray absorptiometry
  146. Clinical analysis of AN69ST membrane continuous venous hemofiltration in the treatment of severe sepsis
  147. Antibiotics therapy combined with probiotics administered intravaginally for the treatment of bacterial vaginosis: A systematic review and meta-analysis
  148. Construction of a ceRNA network to reveal a vascular invasion associated prognostic model in hepatocellular carcinoma
  149. A pan-cancer analysis of STAT3 expression and genetic alterations in human tumors
  150. A prognostic signature based on seven T-cell-related cell clustering genes in bladder urothelial carcinoma
  151. Pepsin concentration in oral lavage fluid of rabbit reflux model constructed by dilating the lower esophageal sphincter
  152. The antihypertensive felodipine shows synergistic activity with immune checkpoint blockade and inhibits tumor growth via NFAT1 in LUSC
  153. Tanshinone IIA attenuates valvular interstitial cells’ calcification induced by oxidized low density lipoprotein via reducing endoplasmic reticulum stress
  154. AS-IV enhances the antitumor effects of propofol in NSCLC cells by inhibiting autophagy
  155. Establishment of two oxaliplatin-resistant gallbladder cancer cell lines and comprehensive analysis of dysregulated genes
  156. Trial protocol: Feasibility of neuromodulation with connectivity-guided intermittent theta-burst stimulation for improving cognition in multiple sclerosis
  157. LncRNA LINC00592 mediates the promoter methylation of WIF1 to promote the development of bladder cancer
  158. Factors associated with gastrointestinal dysmotility in critically ill patients
  159. Mechanisms by which spinal cord stimulation intervenes in atrial fibrillation: The involvement of the endothelin-1 and nerve growth factor/p75NTR pathways
  160. Analysis of two-gene signatures and related drugs in small-cell lung cancer by bioinformatics
  161. Silencing USP19 alleviates cigarette smoke extract-induced mitochondrial dysfunction in BEAS-2B cells by targeting FUNDC1
  162. Menstrual irregularities associated with COVID-19 vaccines among women in Saudi Arabia: A survey during 2022
  163. Ferroptosis involves in Schwann cell death in diabetic peripheral neuropathy
  164. The effect of AQP4 on tau protein aggregation in neurodegeneration and persistent neuroinflammation after cerebral microinfarcts
  165. Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin resistance
  166. Analysis of clinical characteristics in proximal and distal reflux monitoring among patients with gastroesophageal reflux disease
  167. Exosomal circ-0020887 and circ-0009590 as novel biomarkers for the diagnosis and prediction of short-term adverse cardiovascular outcomes in STEMI patients
  168. Upregulated microRNA-429 confers endometrial stromal cell dysfunction by targeting HIF1AN and regulating the HIF1A/VEGF pathway
  169. Bibliometrics and knowledge map analysis of ultrasound-guided regional anesthesia
  170. Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways
  171. D-dimer trends predict COVID-19 patient’s prognosis: A retrospective chart review study
  172. WTAP affects intracranial aneurysm progression by regulating m6A methylation modification
  173. Using of endoscopic polypectomy in patients with diagnosed malignant colorectal polyp – The cross-sectional clinical study
  174. Anti-S100A4 antibody administration alleviates bronchial epithelial–mesenchymal transition in asthmatic mice
  175. Prognostic evaluation of system immune-inflammatory index and prognostic nutritional index in double expressor diffuse large B-cell lymphoma
  176. Prevalence and antibiogram of bacteria causing urinary tract infection among patients with chronic kidney disease
  177. Reactive oxygen species within the vaginal space: An additional promoter of cervical intraepithelial neoplasia and uterine cervical cancer development?
  178. Identification of disulfidptosis-related genes and immune infiltration in lower-grade glioma
  179. A new technique for uterine-preserving pelvic organ prolapse surgery: Laparoscopic rectus abdominis hysteropexy for uterine prolapse by comparing with traditional techniques
  180. Self-isolation of an Italian long-term care facility during COVID-19 pandemic: A comparison study on care-related infectious episodes
  181. A comparative study on the overlapping effects of clinically applicable therapeutic interventions in patients with central nervous system damage
  182. Low intensity extracorporeal shockwave therapy for chronic pelvic pain syndrome: Long-term follow-up
  183. The diagnostic accuracy of touch imprint cytology for sentinel lymph node metastases of breast cancer: An up-to-date meta-analysis of 4,073 patients
  184. Mortality associated with Sjögren’s syndrome in the United States in the 1999–2020 period: A multiple cause-of-death study
  185. CircMMP11 as a prognostic biomarker mediates miR-361-3p/HMGB1 axis to accelerate malignant progression of hepatocellular carcinoma
  186. Analysis of the clinical characteristics and prognosis of adult de novo acute myeloid leukemia (none APL) with PTPN11 mutations
  187. KMT2A maintains stemness of gastric cancer cells through regulating Wnt/β-catenin signaling-activated transcriptional factor KLF11
  188. Evaluation of placental oxygenation by near-infrared spectroscopy in relation to ultrasound maturation grade in physiological term pregnancies
  189. The role of ultrasonographic findings for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2-negative breast cancer
  190. Construction of immunogenic cell death-related molecular subtypes and prognostic signature in colorectal cancer
  191. Long-term prognostic value of high-sensitivity cardiac troponin-I in patients with idiopathic dilated cardiomyopathy
  192. Establishing a novel Fanconi anemia signaling pathway-associated prognostic model and tumor clustering for pediatric acute myeloid leukemia patients
  193. Integrative bioinformatics analysis reveals STAT2 as a novel biomarker of inflammation-related cardiac dysfunction in atrial fibrillation
  194. Adipose-derived stem cells repair radiation-induced chronic lung injury via inhibiting TGF-β1/Smad 3 signaling pathway
  195. Real-world practice of idiopathic pulmonary fibrosis: Results from a 2000–2016 cohort
  196. lncRNA LENGA sponges miR-378 to promote myocardial fibrosis in atrial fibrillation
  197. Diagnostic value of urinary Tamm-Horsfall protein and 24 h urine osmolality for recurrent calcium oxalate stones of the upper urinary tract: Cross-sectional study
  198. The value of color Doppler ultrasonography combined with serum tumor markers in differential diagnosis of gastric stromal tumor and gastric cancer
  199. The spike protein of SARS-CoV-2 induces inflammation and EMT of lung epithelial cells and fibroblasts through the upregulation of GADD45A
  200. Mycophenolate mofetil versus cyclophosphamide plus in patients with connective tissue disease-associated interstitial lung disease: Efficacy and safety analysis
  201. MiR-1278 targets CALD1 and suppresses the progression of gastric cancer via the MAPK pathway
  202. Metabolomic analysis of serum short-chain fatty acid concentrations in a mouse of MPTP-induced Parkinson’s disease after dietary supplementation with branched-chain amino acids
  203. Cimifugin inhibits adipogenesis and TNF-α-induced insulin resistance in 3T3-L1 cells
  204. Predictors of gastrointestinal complaints in patients on metformin therapy
  205. Prescribing patterns in patients with chronic obstructive pulmonary disease and atrial fibrillation
  206. A retrospective analysis of the effect of latent tuberculosis infection on clinical pregnancy outcomes of in vitro fertilization–fresh embryo transferred in infertile women
  207. Appropriateness and clinical outcomes of short sustained low-efficiency dialysis: A national experience
  208. miR-29 regulates metabolism by inhibiting JNK-1 expression in non-obese patients with type 2 diabetes mellitus and NAFLD
  209. Clinical features and management of lymphoepithelial cyst
  210. Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia
  211. ENPP1 ameliorates vascular calcification via inhibiting the osteogenic transformation of VSMCs and generating PPi
  212. Significance of monitoring the levels of thyroid hormone antibodies and glucose and lipid metabolism antibodies in patients suffer from type 2 diabetes
  213. The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study
  214. Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units
  215. Identification of diagnostic immune-related gene biomarkers for predicting heart failure after acute myocardial infarction
  216. Long-term administration of probiotics prevents gastrointestinal mucosal barrier dysfunction in septic mice partly by upregulating the 5-HT degradation pathway
  217. miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor
  218. Diagnostic and prognostic value of MR-pro ADM, procalcitonin, and copeptin in sepsis
  219. Review Articles
  220. Prenatal diagnosis of fetal defects and its implications on the delivery mode
  221. Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis
  222. Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
  223. Saddle pulmonary embolism in the setting of COVID-19 infection: A systematic review of case reports and case series
  224. Vitamin C and epigenetics: A short physiological overview
  225. Ebselen: A promising therapy protecting cardiomyocytes from excess iron in iron-overloaded thalassemia patients
  226. Aspirin versus LMWH for VTE prophylaxis after orthopedic surgery
  227. Mechanism of rhubarb in the treatment of hyperlipidemia: A recent review
  228. Surgical management and outcomes of traumatic global brachial plexus injury: A concise review and our center approach
  229. The progress of autoimmune hepatitis research and future challenges
  230. METTL16 in human diseases: What should we do next?
  231. New insights into the prevention of ureteral stents encrustation
  232. VISTA as a prospective immune checkpoint in gynecological malignant tumors: A review of the literature
  233. Case Reports
  234. Mycobacterium xenopi infection of the kidney and lymph nodes: A case report
  235. Genetic mutation of SLC6A20 (c.1072T > C) in a family with nephrolithiasis: A case report
  236. Chronic hepatitis B complicated with secondary hemochromatosis was cured clinically: A case report
  237. Liver abscess complicated with multiple organ invasive infection caused by hematogenous disseminated hypervirulent Klebsiella pneumoniae: A case report
  238. Urokinase-based lock solutions for catheter salvage: A case of an upcoming kidney transplant recipient
  239. Two case reports of maturity-onset diabetes of the young type 3 caused by the hepatocyte nuclear factor 1α gene mutation
  240. Immune checkpoint inhibitor-related pancreatitis: What is known and what is not
  241. Does total hip arthroplasty result in intercostal nerve injury? A case report and literature review
  242. Clinicopathological characteristics and diagnosis of hepatic sinusoidal obstruction syndrome caused by Tusanqi – Case report and literature review
  243. Synchronous triple primary gastrointestinal malignant tumors treated with laparoscopic surgery: A case report
  244. CT-guided percutaneous microwave ablation combined with bone cement injection for the treatment of transverse metastases: A case report
  245. Malignant hyperthermia: Report on a successful rescue of a case with the highest temperature of 44.2°C
  246. Anesthetic management of fetal pulmonary valvuloplasty: A case report
  247. Rapid Communication
  248. Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
  249. Erratum
  250. Erratum to “Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway”
  251. Erratum to: “Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p”
  252. Retraction
  253. Retraction of “Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients”
  254. Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
  255. Retraction of “miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells”
  256. Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”
  257. Retraction of “circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury”
  258. Retraction of “lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells”
  259. Special issue Linking Pathobiological Mechanisms to Clinical Application for cardiovascular diseases
  260. Effect of cardiac rehabilitation therapy on depressed patients with cardiac insufficiency after cardiac surgery
  261. Special issue The evolving saga of RNAs from bench to bedside - Part I
  262. FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma
  263. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part III
  264. Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer
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Heruntergeladen am 11.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/med-2023-0684/html
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