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AG1024, an IGF-1 receptor inhibitor, ameliorates renal injury in rats with diabetic nephropathy via the SOCS/JAK2/STAT pathway

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Published/Copyright: April 6, 2023
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Open Medicine
From the journal Open Medicine Volume 18 Issue 1

Abstract

Insulin-like-growth factor-1 (IGF-1) is the ligand for insulin-like growth factor-1 receptor (IGF-1R), and the roles of IGF-1/IGF-1R in diabetic nephropathy (DN) are well-characterized previously. However, the biological functions of AG1024 (an IGF-1R inhibitor) in DN remain unknown. This study investigates the roles and related mechanisms of AG-1024 in DN. The experimental DN was established via intraperitoneal injection of streptozotocin, and STZ-induced diabetic rats were treated with AG1024 (20 mg/kg/day) for 8 weeks. The 24 h proteinuria, blood glucose level, serum creatinine, and blood urea nitrogen were measured for biochemical analyses. The increase in 24 h proteinuria, blood glucose level, serum creatinine, and blood urea of DN rats were conspicuously abated by AG1024. After biochemical analyses, the renal tissue specimens were collected, and as revealed by hematoxylin and eosin staining and Masson staining, AG-1024 mitigated typical renal damage and interstitial fibrosis in DN rats. Then, the anti-inflammatory effect of AG-1024 was assessed by western blotting and ELISA. Mechanistically, AG-1024 upregulated SOCS1 and SOCS3 expression and decreased phosphorylated JAK2, STAT1, and STAT3, as shown by western blotting. Collectively, AG-1024 (an IGF-1R inhibitor) ameliorates renal injury in experimental DN by attenuating renal inflammation and fibrosis via the SOCS/JAK2/STAT pathway.

Keywords: diabetic nephropathy; IGF-1 receptor; AG1024; fibrosis; inflammation; SOCS

1 Introduction

Diabetes is a metabolic disorder with frequent occurrence and death rates [1]. Diabetic nephropathy (DN) is one of the most common and severe complications in diabetes mellitus patients and is the leading cause of end-stage renal disease [2]. The high incidence of DN in diabetes patients is approximately 30–40% [3]. Currently, despite available agents, the management of DN is still challenging [4]. The current therapeutic options have limited efficacy and adverse effects. Meanwhile, DN incidence is still increasing gradually [5]. Therefore, there is an urgent need to explore DN pathogenesis and initiate novel therapeutic options for DN intervention.

Inflammation is an indispensable player in DN pathogenesis [6]. Interleukin (IL)-6, mononuclear chemotactic protein-1 (MCP-1), and IL-1β are the most-studied inflammatory cytokines associated with renal inflammation and upregulation of these cytokines has been suggested to be associated with DN progression [7]. The fibroblasts recruited by the continuous effects of inflammation finally lead to renal fibrosis [8]. Diabetic renal fibrosis is attributed to glomerulosclerosis and renal tubulointerstitial fibrosis induced by excessive deposition of extracellular matrix (ECM), including fibronectin and collagen IV, causing DN pathogenesis [9]. Accumulation of ECM can be induced by activation of the transforming growth factor-β (TGF-β) [10]. TGF-β, as reported, is highly expressed in diabetic models, and its inhibition can prevent glomerular enlargement and reduce fibrosis [11]. Collectively, attenuation of inflammation and fibrosis by reducing inflammatory cytokines, decreasing accumulation of ECM, and inactivation of TGF-β, is a promising option for DN treatment.

The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway are involved in inflammation, and the activated JAK/STAT signal can intensify glomerular mesangial cell proliferation and matrix expansion, causing DN pathogenesis [12]. The JAK/STAT cascade comprises a few principal components. JAK1-3 and TYK2 are identified in the JAK family, and the STAT family has seven members, including STAT1-4, 5A/B, and 6 [13]. The binding of ligands to their receptors triggers the JAK/STAT signal cascade and subsequently regulates the expression of target genes encoding cytokines, chemokines, adherence molecules, and inducible enzymes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) [14]. Previous findings suggest that the JAK/STAT pathway, especially the JAK2/STAT1/STAT3-dependent axis, contributes to high glucose-mediated renal cell responses, including enhanced expression of genes involved in leukocyte infiltration, cell growth, and fibrosis [15–18]. Moreover, diverse approaches, including JAK2 inhibition, STAT1 antisense oligonucleotides, and STAT3 gene knockdown, have been proven to counteract the harmful effects of JAK/STAT activation in cultured renal cells [17,19–21] and in the development of diabetes in vivo [18,21]. The JAK/STAT pathway is negatively regulated by various mechanisms including the suppressor of cytokine signaling (SOCS) proteins. SOCS family members (CIS; SOCS1-7), particularly SOCS1 and SOCS3, control the magnitude and duration of JAK/STAT signaling [22]. Studies have shown that overexpression of SOCS in the kidney can relieve the progression of DN by inhibiting the JAK/STAT pathway [23,24]. Therefore, this study focuses on the prognostic value of the SOCS/JAK2/STAT1/STAT3 axis for DN.

Insulin-like growth factor-1 (IGF-1), strongly regulating glomerular and tubular cells, is a growth factor for maintaining the nephritic structure and function and is an important player in DN pathogenesis [25]. Previous studies reveal that IGF-1 overexpression induces kidney tissue hyperplasia, renal cell proliferation, nephromegaly, mesangial expansion, and increased expression of inflammatory cytokines and ECM proteins [26]. IGF-1 is the ligand for the insulin-like growth factor-1 receptor (IGF-1R) [27]. IGF-1R inhibitor is suggested to decrease mesangial matrix and exapnsion in kidneys [28], alleviate inflammatory response and renal fibrosis [29,30] and stabilize podocyte integrity and reduce glomerular proteinuria in high-glucose-stimulated podocytes under diabetic conditions [31]. However, the biological functions of AG1024 (an IGF-1R inhibitor) in DN remain unknown. Hence, this study purposed to detect the biological functions of AG1024 and whether its functions were mediated by the SOCS/JAK2/STAT1/STAT3 axis in DN. We hypothesized that AG1024 would alleviate DN-like symptoms in animals. We believed that AG1024 may be an effective strategy for DN prevention.

2 Materials and methods

2.1 Experimental animals

A total of 60 Wistar rats (female, 8 weeks, 200–220 g) were purchased from the Jiangsu Aniphe Biolaboratory Inc and housed in a specific pathogen-free facility (55 ± 2% humidity, 21 ± 2°C, 12 h light/dark cycle) with free water and food.

2.2 Animal model and groupings

After 7 days of acclimation, the rats were randomly assigned into the control, the DN, the DN + AG1024, and the DN + metformin groups. Each group had 15 rats. The overnight-fasted rats were intraperitoneally injected with 2% pentobarbital sodium (40 mg/kg; Bio-techne, Shanghai, China) followed by the removal of the right kidneys. After 2 weeks, the rats in the DN groups received a single intraperitoneal injection of freshly prepared streptozotocin (STZ; 50 mg/kg) dissolved in ice-cold citrate buffer (10 mmol/L, pH 4.5) obtained from Sigma-Aldrich (Shanghai, China). In parallel, the rats were intraperitoneally injected with an equal volume of the citrate buffer without STZ. All animals were returned to their cages after complete recovery from anesthesia. After 72 h, blood samples were isolated from the tails to determine blood glucose levels, and the successful establishment criterion was a level >16.7 mmol/L. Insulin was not allowed in this study to avoid various effects of exogenous insulin.

The controls were injected once with citrate buffer and 0.5 mL saline daily for 12 weeks. After 4 weeks of cultivation, the diabetic rats in the DN group received 0.5 mL saline daily, those in the DN + AG1024 group were administered with AG1024 (20 mg/kg/day, po), and those in the DN + metformin group were given with metformin (200 mg/kg/day) by gavage for 8 weeks. AG1024 (purity 99.82%) and metformin (purity 99.64%) were purchased from MedChemExpress (Shanghai, China). The dosages of AG1024 and metformin were determined as previously documented [32,33].

2.3 Biochemical analyses

The body weight of each rat was monitored after drug administration. All rats were then housed in special metabolic cages for collecting 24 h urine, and the specimens were centrifuged at 3,000 rpm for 10 min at 4°C. The supernatant was used to measure the proteinuria concentration using ELISA. The collected blood samples from the right jugular artery were subjected to 10 min centrifugation at 3,000 rpm at 4°C, and the blood glucose, serum creatinine, and blood urea nitrogen concentrations were measured using commercially diagnostic available kits (Spinreact, Girona, Spain) by an enzymatic colorimetric method. After biochemical analyses, the rats were sacrificed by decapitation under anesthesia using 2% pentobarbital sodium (50 mg/kg), and renal tissue specimens were collected for subsequent use.

2.4 Histopathological examinations

The kidney tissues were fixed in 10% neutral buffered formalin for 24 h, paraffin-embedded, and sectioned into 4 μm-thick slices. The sections were stained with hematoxylin and eosin (H&E; Yuanye Biotechnology, Shanghai, China) and Masson’s trichrome (Solarbio, Beijing, China). The morphological changes were observed under a light microscope (Leica, Wetzlar, Germany).

2.5 ELISA

Measurement of inflammatory cytokines, including IL-6, MCP-1, IL-1β, and IGF-1 in renal tissues, was performed using specific ELISA kits (Boster Biotechnology, Wuhan, China).

2.6 Western blotting

Rat renal tissues were homogenized in 0.5 mL of radioimmunoprecipitation assay (RIPA) lysis buffer (Solarbio) for protein separation. The protein concentration of each sample was estimated using a BCA protein assay kit (Vazyme, Nanjing, China). For detection of protein levels, protein lysates (40 μg protein loaded per lane) for each group of tissues were separated by sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE) gels and transferred onto polyvinylidene fluoride (PVDF) membranes followed by blocking using 5% nonfat milk. After 1 h of blocking, the membrane was incubated overnight with primary antibodies against IGF-1R (ab182408, 1:1,000; Abcam), β-actin (ab115777, 1:200; Abcam), COX2 (ab179800, 1:2,500; Abcam), iNOS (ab178945, 1:1,000; Abcam), TGF-β (ab179695, 1:1,000; Abcam), collagen IV (ab6586, 1:500; Abcam), fibronectin (ab45688, 1:3,000; Abcam), p-JAK2 (ab32101, 1:2,000; Abcam), JAK2 (ab108596, 1:5,000; Abcam), p-STAT1 (ab109461, 1:5,000; Abcam), STAT1 (ab230428, 1:750; Abcam), p-STAT3 (ab32143, 1:5,000; Abcam), STAT3 (ab68153, 1:2,000; Abcam), SOCS1 (ab65989, 1 μg/mL; Abcam), and SOCS3 (ab280884, 1:1,000; Abcam) at 4°C. Then, the membrane was incubated with anti-rabbit (ab97051, 1:20,000; Abcam) at room temperature for 2 h. The proteins were visualized with an enhanced chemiluminescence detection kit (Beyotime, Shanghai, China).

2.7 Statistics analysis

All data were analyzed using GraphPad Prism 6.0 software (GraphPad Inc, San Diego, CA, USA) and expressed as mean ± standard deviation. Statistical analysis was performed using Student’s t-test or one-way analysis of variance followed by Tukey’s post hoc test. P-value < 0.05 was considered statistically significant.

  1. Ethical/Institutional review board approval: The experimental protocols were granted approval by the Ethics Committee of The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, and were designed consistent with the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals.

3 Results

3.1 AG-1024 attenuates the metabolic disorders in an experimental rat model of DN

The renal tissues were collected 12 weeks after STZ injection, and the results of western blotting revealed that DN insult increased the protein level of IGF-1R, which was attenuated by AG1024 and metformin (Figure 1a). Then, the levels of IGF-1 in renal tissues from different groups were measured by ELISA, and the results revealed that the IGF-1 level was decreased in diabetic rats after administration of AG1024 or metformin (Figure 1b). Additionally, the promotion of 24 h proteinuria, blood glucose level, serum creatinine, and blood urea nitrogen in STZ-administered rats was abolished by AG1024. The positive control metformin had similar efficacy to AG1024 (Figure 1c–f). The above findings indicate that AG-1024 (an IGF-1R inhibitor) attenuates the metabolic disorders in the rat model of DN.

Figure 1 AG-1024 ameliorates metabolic disorders in rats with DN. (a) The protein levels of IGF-1R in renal tissues obtained from rats of the control, the DN, the DN + AG1024, and the DN + metformin groups were detected by western blotting. (b) ELISA of IGF-1 levels. (c) ELISA of 24-h proteinuria. (d) Blood glucose. (e) Serum creatinine. (f) Blood urea nitrogen. **p < 0.01 and ***p < 0.001. DN, diabetic nephropathy.
Figure 1

AG-1024 ameliorates metabolic disorders in rats with DN. (a) The protein levels of IGF-1R in renal tissues obtained from rats of the control, the DN, the DN + AG1024, and the DN + metformin groups were detected by western blotting. (b) ELISA of IGF-1 levels. (c) ELISA of 24-h proteinuria. (d) Blood glucose. (e) Serum creatinine. (f) Blood urea nitrogen. **p < 0.01 and ***p < 0.001. DN, diabetic nephropathy.

3.2 AG-1024 improves the renal function of diabetic rats

As revealed by H&E staining, the diabetic rats exhibited typical renal damage, including glomerular mesangial hyperplasia, ECM accumulation and expansion, glomerular sclerosis, atrophy, and inflammatory cell infiltration. After AG1024 administration, the abnormality of renal tissue morphology was alleviated, and the effect of AG1024 was similar to the positive control metformin (Figure 2a). Additionally, the diabetic rats showed decreased glomerular volume after administration of AG1024 or metformin (Figure 2b). Collectively, AG-1024 (an IGF-1R inhibitor) attenuates renal lesions in diabetic rats.

Figure 2 AG-1024 improves renal function in STZ-induced diabetic rats. (a) The H&E-stained renal tissues in the control, the DN, the DN + AG1024, and the DN + metformin groups (scale bar = 100 μm). (b) Quantification of glomerular volume. **p < 0.01. DN, diabetic nephropathy.
Figure 2

AG-1024 improves renal function in STZ-induced diabetic rats. (a) The H&E-stained renal tissues in the control, the DN, the DN + AG1024, and the DN + metformin groups (scale bar = 100 μm). (b) Quantification of glomerular volume. **p < 0.01. DN, diabetic nephropathy.

3.3 AG-1024 ameliorates renal inflammation in diabetic rats

To explore the anti-inflammatory effects of AG-1024, we evaluated its effects on the expression of COX-2 and iNOS, key enzymes in the inflammatory processes of DN. The results of western blotting demonstrated that the expression of COX2 and iNOS in the kidneys of diabetic rats was significantly increased compared to the normal control group, while AG1024 or metformin administration attenuated the elevated expression of COX2 and iNOS (Figure 3a). Inflammatory cytokines are thought to play pivotal roles in the pathogenesis of DN. Cytokines including IL-6, MCP-1, and IL-1β are correlated with deterioration of the renal function [34]. We measured the expression of IL-6, MCP-1, and IL-1β in diabetic rat kidneys using ELISA. The results showed that administration of AG1024 or metformin abolished the DN-induced promotion in levels of inflammatory cytokines (Figure 3b–d). Taken together, the administration of AG-1024 (an IGF-1R inhibitor) attenuates renal inflammation.

Figure 3 AG-1024 ameliorates renal inflammation in diabetic rats. (a) The protein levels of COX2 and iNOS in the renal tissues. ELISA of the (b) IL-6 level, (c) MCP-1 level, and (d) IL-1β level. **p < 0.01 and ***p < 0.001.
Figure 3

AG-1024 ameliorates renal inflammation in diabetic rats. (a) The protein levels of COX2 and iNOS in the renal tissues. ELISA of the (b) IL-6 level, (c) MCP-1 level, and (d) IL-1β level. **p < 0.01 and ***p < 0.001.

3.4 AG-1024 reduces fibrosis formation in diabetic rats

The results of Masson staining revealed that the area of interstitial fibrosis was increased after DN induction. However, the administration of AG1024 or metformin has the opposite effects (Figure 4a and b). Then, the findings were confirmed via the western blotting method. The levels of fibrosis-associated proteins (TGF-β, collagen IV, and fibronectin) were decreased in diabetic rats after treatment with AG1024 or metformin (Figure 4c). Taken together, AG-1024 (an IGF-1R inhibitor) protects renal tissues from DN-induced fibrosis.

Figure 4 AG-1024 reduces fibrosis formation in diabetic rats. (a) Masson-stained renal tissues (scale bar = 100 μm). (b) Quantification of renal interstitial area. (c) The protein levels of TGF-β, collagen IV, and fibronectin. **p < 0.01 and ***p < 0.001.
Figure 4

AG-1024 reduces fibrosis formation in diabetic rats. (a) Masson-stained renal tissues (scale bar = 100 μm). (b) Quantification of renal interstitial area. (c) The protein levels of TGF-β, collagen IV, and fibronectin. **p < 0.01 and ***p < 0.001.

3.5 AG-1024 upregulates SOCS1/3 expression and inactivates the JAK/STAT pathway

To investigate whether the protective effect of AG-1024 was related to the JAK2/STAT1/STAT3 axis, western blotting was performed to detect the levels of phosphorylated JAK2, phosphorylated STAT1, and phosphorylated STAT3. The results showed that AG1024 or metformin administration reduced the phosphorylation of JAK2, STAT1, and STAT3 in rats with DN (Figure 5a). To detect the mechanism of the JAK/STAT cascade, the protein levels of SOCS1 and SOCS3 were measured. The protein levels of SOCS1 and SOCS3 were significantly elevated by AG-1024 in diabetic rats, as shown by western blotting (Figure 5b). Figure 6 presents the scientific schematic diagram depicting the mechanisms by which AG1024 alleviates renal injury in experimental DN. In conclusion, AG-1024 upregulates the SOCS1/3 expression and inactivates the JAK2/STAT1/STAT3 axis.

Figure 5 AG-1024 upregulates SOCS1/2 expression and inactivates the JAK2/STAT1/STAT3 axis. (a) The protein levels of phosphorylated JAK2, STAT1, and STAT3. (b) The protein levels of SOCS1 and SOCS3. * p < 0.05, **p < 0.01, and ***p < 0.001.
Figure 5

AG-1024 upregulates SOCS1/2 expression and inactivates the JAK2/STAT1/STAT3 axis. (a) The protein levels of phosphorylated JAK2, STAT1, and STAT3. (b) The protein levels of SOCS1 and SOCS3. * p < 0.05, **p < 0.01, and ***p < 0.001.

Figure 6 Schematic diagram depicting AG-1024 alleviates renal injury in experimental DN.
Figure 6

Schematic diagram depicting AG-1024 alleviates renal injury in experimental DN.

4 Discussion

This study first demonstrated that IGF-1R was upregulated in renal tissues collected from experimental DN, and thereafter revealed the biological effects of its inhibitor (AG-1024) on metabolic parameters, renal morphological changes, renal inflammation, and renal fibrosis. Finally, we detected whether the protection of the IGF-1R inhibitor was associated with the JAK/STAT signaling and SOCS family.

Renal inflammation and fibrosis are critical players in DN pathogenesis and development. These two pathological processes are induced by profibrotic factors and inflammatory cytokines [16]. Glomerular inflammatory infiltration and progressive glomerulosclerosis facilitate podocyte demise and urinary albumin excretion in diabetic renal fibrosis [35]. AG1024 is found to attenuate inflammation and proliferation of neurotensin in colonic epithelial cells [36]. Additionally, other IGF-1R inhibitors, including GSK4529, can ameliorate diabetic kidney disease by amelioration of inflammatory infiltration and tubulointerstitial fibrosis by suppressing Snail1 expression [29]. Moreover, (−)-epigallocatechin gallate is found to attenuate chronic inflammation and improve hyperinsulinemia by blocking the IGF/IGF-1R axis [37], insulin deficiency induces rat renal mesangial cell dysfunction by activating IGF-1/IGF-1R signaling [38], and the anti-fibrotic effects of berberine are associated with decreased myocardial IGF-1R in diabetes [39]. In the current study, we found that AG1024 administration attenuated metabolic disorders and histopathological changes and decreased the levels of inflammatory cytokines, inducible enzymes, and fibrosis-associated proteins in DN rats, indicating that AG-1024 alleviates renal injury via attenuation of renal inflammation and fibrosis in diabetic rats.

The JAK/STAT pathway can regulate inflammation, proliferation, and the transmission of fibrotic responses [40]. Pharmacological modulation of this signaling has therapeutic potential in DN. Antidiabetic, cholesterol-lowering, and anti-hypertensive drugs are found to inactivate the JAK/STAT pathway during diabetes and mitigate renal inflammation in experimental DN [41]. AG1024 is found to decrease the expression of phosphorylated AKT in BCR-ABL-expressing cells and colonic epithelial cells [36,42], and also has been suggested to downregulate the expression of phosphorylated AKT and STAT3 in DU145 cells [43]. The current study showed that the administration of AG1024 inhibited the phosphorylation of JAK2, STAT1, and STAT3 in diabetic rats. Studies have recognized SOCS expression as an endogenous mechanism to regulate JAK/STAT overactivation in renal diseases [23,24]. As reported, SOCS proteins can negatively mediate the JAK/STAT pathway [44]. Delivery of SOCS1-3 proteins in experimental models of DN can mitigate the pathological features of DN [45,46]. Here, we found that protein levels of SOCS1 and SOCS3 were significantly upregulated by AG1024. In conclusion, AG1024, an IGF-1R inhibitor, ameliorates renal injury by attenuating renal inflammation and fibrosis by the SOCS/JAK/STAT pathway.

There are limitations to this study. First, studies on the specific functions of this pathway are lacking. Further experiments are required to investigate the functions of the overexpressed or blocked pathway in the context of AG-1024. Second, clinical data of patients are lacking. Third, experiments were performed at a single time point; additional time points also require investigation. Despite these limitations, we believe that AG1024 may be promising for DN prevention.

# These authors contributed equally to the work.

  1. Funding information: This work was supported by Hubei Provincial Health Commission, Key Projects of Provincial and Municipal Joint Projects (Approval number: WG19A02), and Wuhan Municipal Health Commission Fund Project (Approval number: WX20Q33).

  2. Author contributions: Jianhua Liu and Yun Zhang conceived and designed the experiments. Jianhua Liu, Yun Zhang, Min Liu, Feng Shi, and Bo Cheng carried out the experiments. Jianhua Liu, Yun Zhang, and Bo Cheng analyzed the data. Jianhua Liu, Yun Zhang, and Bo Cheng drafted the manuscript. All authors agreed to be accountable for all aspects of the work. All authors have read and approved the final manuscript.

  3. Conflict of interest: Authors state no conflict of interest.

  4. Data availability statement: The data that support the findings of this study are available from the corresponding author on reasonable request.

References

[1] Turkmen K, Karagoz A, Kucuk A. Sirtuins as novel players in the pathogenesis of diabetes mellitus. World J Diabetes. 2014;5(6):894–900. 10.4239/wjd.v5.i6.894.Search in Google Scholar PubMed PubMed Central

[2] Adeshara KA, Diwan AG, Tupe RS. Diabetes and complications: Cellular signaling pathways, current understanding and targeted therapies. Curr drug targets. 2016;17(11):1309–28. 10.2174/1389450117666151209124007.Search in Google Scholar PubMed

[3] Reddy MA, Tak Park J, Natarajan R. Epigenetic modifications in the pathogenesis of diabetic nephropathy. Semnephrology. 2013;33(4):341–53. 10.1016/j.semnephrol.2013.05.006.Search in Google Scholar PubMed PubMed Central

[4] Lin YC, Chang YH, Yang SY, Wu KD, Chu TS. Update of pathophysiology and management of diabetic kidney disease. J Formos Med Assoc. 2018;117(8):662–75. 10.1016/j.jfma.2018.02.007.Search in Google Scholar PubMed

[5] Johnson SA, Spurney RF. Twenty years after ACEIs and ARBs: emerging treatment strategies for diabetic nephropathy. Am J Physiol Ren Physiol. 2015;309(10):F807–20. 10.1152/ajprenal.00266.2015.Search in Google Scholar PubMed PubMed Central

[6] Moreno JA, Gomez-Guerrero C, Mas S, Sanz AB, Lorenzo O, Ruiz-Ortega M, et al. Targeting inflammation in diabetic nephropathy: A tale of hope. Expert Opin Investig Drugs. 2018;27(11):917–30. 10.1080/13543784.2018.1538352.Search in Google Scholar PubMed

[7] Garrido W, Jara C, Torres A, Suarez R, Cappelli C, Oyarzún C, et al. Blockade of the adenosine A(3) receptor attenuates caspase 1 activation in renal tubule epithelial cells and decreases interleukins IL-1β and IL-18 in diabetic rats. Int J Mol Sci. 2019;20(18):4531. 10.3390/ijms20184531.Search in Google Scholar PubMed PubMed Central

[8] Liu Y. Renal fibrosis: New insights into the pathogenesis and therapeutics. Kidney Int. 2006;69(2):213–7. 10.1038/sj.ki.5000054.Search in Google Scholar PubMed

[9] Adelusi TI, Du L, Hao M, Zhou X, Xuan Q, Apu C, et al. Keap1/Nrf2/ARE signaling unfolds therapeutic targets for redox imbalanced-mediated diseases and diabetic nephropathy. Biomed Pharmacother = Biomedecine & pharmacotherapie. 2020;123:109732. 10.1016/j.biopha.2019.109732.Search in Google Scholar PubMed

[10] Tang PM, Zhang YY, Mak TS, Tang PC, Huang XR, Lan HY. Transforming growth factor-β signalling in renal fibrosis: from Smads to non-coding RNAs. J Physiol. 2018;596(16):3493–503. 10.1113/jp274492.Search in Google Scholar

[11] Gagliardini E, Benigni A. Role of anti-TGF-beta antibodies in the treatment of renal injury. Cytokine Growth Factor Rev. 2006;17(1–2):89–96. 10.1016/j.cytogfr.2005.09.005.Search in Google Scholar PubMed

[12] Marrero MB, Banes-Berceli AK, Stern DM, Eaton DC. Role of the JAK/STAT signaling pathway in diabetic nephropathy. Am J Physiol Ren Physiol. 2006;290(4):F762–8. 10.1152/ajprenal.00181.2005.Search in Google Scholar PubMed

[13] Darnell JE Jr. STATs and gene regulation. Science (New York, NY). 1997;277(5332):1630–5. 10.1126/science.277.5332.1630.Search in Google Scholar PubMed

[14] Yu H, Liu Z, Zhou H, Dai W, Chen S, Shu Y, et al. JAK-STAT pathway modulates the roles of iNOS and COX-2 in the cytoprotection of early phase of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress. Neurosci Lett. 2012;529(2):166–71. 10.1016/j.neulet.2012.09.013.Search in Google Scholar PubMed

[15] Huang JS, Chuang LY, Guh JY, Huang YJ, Hsu MS. Antioxidants attenuate high glucose-induced hypertrophic growth in renal tubular epithelial cells. Am J Physiol Ren Physiol. 2007;293(4):F1072–82. 10.1152/ajprenal.00020.2007.Search in Google Scholar PubMed

[16] Brosius FC 3rd. New insights into the mechanisms of fibrosis and sclerosis in diabetic nephropathy. Rev Endocr Metab Disord. 2008;9(4):245–54. 10.1007/s11154-008-9100-6.Search in Google Scholar PubMed PubMed Central

[17] de Prati AC, Ciampa AR, Cavalieri E, Zaffini R, Darra E, Menegazzi M, et al. STAT1 as a new molecular target of anti-inflammatory treatment. Curr Med Chem. 2005;12(16):1819–28. 10.2174/0929867054546645.Search in Google Scholar PubMed

[18] Lu TC, Wang ZH, Feng X, Chuang PY, Fang W, Shen Y, et al. Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy. Kidney Int. 2009;76(1):63–71. 10.1038/ki.2009.98.Search in Google Scholar PubMed PubMed Central

[19] Wang X, Shaw S, Amiri F, Eaton DC, Marrero MB. Inhibition of the Jak/STAT signaling pathway prevents the high glucose-induced increase in tgf-beta and fibronectin synthesis in mesangial cells. Diabetes. 2002;51(12):3505–9. 10.2337/diabetes.51.12.3505.Search in Google Scholar PubMed

[20] Neria F, Castilla MA, Sanchez RF, Gonzalez Pacheco FR, Deudero JJ, Calabia O, et al. Inhibition of JAK2 protects renal endothelial and epithelial cells from oxidative stress and cyclosporin A toxicity. Kidney Int. 2009;75(2):227–34. 10.1038/ki.2008.487.Search in Google Scholar PubMed

[21] Shi YH, Zhao S, Wang C, Li Y, Duan HJ. Fluvastatin inhibits activation of JAK and STAT proteins in diabetic rat glomeruli and mesangial cells under high glucose conditions. Acta Pharmacol Sin. 2007;28(12):1938–46. 10.1111/j.1745-7254.2007.00653.x.Search in Google Scholar PubMed

[22] Linossi EM, Babon JJ, Hilton DJ, Nicholson SE. Suppression of cytokine signaling: The SOCS perspective. Cytokine Growth Factor Rev. 2013;24(3):241–8. 10.1016/j.cytogfr.2013.03.005.Search in Google Scholar PubMed PubMed Central

[23] Ortiz-Muñoz G, Lopez-Parra V, Lopez-Franco O, Fernandez-Vizarra P, Mallavia B, Flores C, et al. Suppressors of cytokine signaling abrogate diabetic nephropathy. J Am Soc Nephrol. 2010;21(5):763–72. 10.1681/asn.2009060625.Search in Google Scholar PubMed PubMed Central

[24] Berthier CC, Zhang H, Schin M, Henger A, Nelson RG, Yee B, et al. Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy. Diabetes. 2009;58(2):469–77. 10.2337/db08-1328.Search in Google Scholar PubMed PubMed Central

[25] Bach LA, Hale LJ. Insulin-like growth factors and kidney disease. Am J Kidney Dis: Off J Natl Kidney Found. 2015;65(2):327–36. 10.1053/j.ajkd.2014.05.024.Search in Google Scholar PubMed

[26] Rajpathak SN, Gunter MJ, Wylie-Rosett J, Ho GY, Kaplan RC, Muzumdar R, et al. The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes. Diabetes Metab Res Rev. 2009;25(1):3–12. 10.1002/dmrr.919.Search in Google Scholar PubMed PubMed Central

[27] Rajala A, Teel K, Bhat MA, Batushansky A, Griffin TM, Purcell L, et al. Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection. Cell Death Dis. 2022;13(7):613. 10.1038/s41419-022-05074-3.Search in Google Scholar PubMed PubMed Central

[28] Yu J, Da J, Dong R, Sun Y, Nie Y, Yu F, et al. IGF-1R Inhibitor Ameliorates Diabetic Nephropathy with Suppressed HMGN1/TLR4 Pathway. Endocr Metab Immune Disord Drug Targets. 2018;18(3):241–50. 10.2174/1871530318666180131102707.Search in Google Scholar PubMed

[29] Dong R, Yu J, Yu F, Yang S, Qian Q, Zha Y. IGF-1/IGF-1R blockade ameliorates diabetic kidney disease through normalizing Snail1 expression in a mouse model. Am J Physiol Endocrinol Metab. 2019;317(4):E686–e98. 10.1152/ajpendo.00071.2019.Search in Google Scholar PubMed

[30] Li J, Dong R, Yu J, Yi S, Da J, Yu F, et al. Inhibitor of IGF1 receptor alleviates the inflammation process in the diabetic kidney mouse model without activating SOCS2. Drug Des Devel Ther. 2018;12:2887–96. 10.2147/dddt.S171638.Search in Google Scholar PubMed PubMed Central

[31] Guo R, Wang P, Zheng X, Cui W, Shang J, Zhao Z. SGLT2 inhibitors suppress epithelial-mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway. Front Pharmacol. 2022;13:897167. 10.3389/fphar.2022.897167.Search in Google Scholar PubMed PubMed Central

[32] Jamroz-Wiśniewska A, Wójcicka G, Łowicka E, Ksiazek M, Bełtowski J. Transactivation of epidermal growth factor receptor in vascular and renal systems in rats with experimental hyperleptinemia: role in leptin-induced hypertension. Biochem Pharmacol. 2008;75(8):1623–38. 10.1016/j.bcp.2008.01.003.Search in Google Scholar PubMed

[33] Dey P, Kundu A, Lee HE, Kar B, Vishal V, Dash S, et al. Molineria recurvata ameliorates streptozotocin-induced diabetic nephropathy through antioxidant and anti-inflammatory pathways. Molecules (Basel, Switz). 2022;27(15):4985. 10.3390/molecules27154985.Search in Google Scholar PubMed PubMed Central

[34] Wada J, Makino H. Inflammation and the pathogenesis of diabetic nephropathy. Clin Sci (London, England: 1979). 2013;124(3):139–52. 10.1042/cs20120198.Search in Google Scholar PubMed

[35] Alicic RZ, Rooney MT, Tuttle KR. Diabetic kidney disease: Challenges, progress, and possibilities. Clin J Am Soc Nephrol. 2017;12(12):2032–45. 10.2215/cjn.11491116.Search in Google Scholar

[36] Zhao D, Bakirtzi K, Zhan Y, Zeng H, Koon HW, Pothoulakis C. Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells. J Biol Chem. 2011;286(8):6092–9. 10.1074/jbc.M110.192534.Search in Google Scholar PubMed PubMed Central

[37] Shimizu M, Sakai H, Shirakami Y, Yasuda Y, Kubota M, Terakura D, et al. Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice. Cancer Prev Res (Philadelphia, Pa). 2011;4(3):396–403. 10.1158/1940-6207.Capr-10-0331.Search in Google Scholar

[38] Kong YL, Shen Y, Ni J, Shao DC, Miao NJ, Xu JL, et al. Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway. Acta Pharmacol Sin. 2016;37(2):217–27. 10.1038/aps.2015.128.Search in Google Scholar PubMed PubMed Central

[39] Li G, Xing W, Zhang M, Geng F, Yang H, Zhang H, et al. Antifibrotic cardioprotection of berberine via downregulating myocardial IGF-1 receptor-regulated MMP-2/MMP-9 expression in diabetic rats. Am J Physiol Heart Circ Physiol. 2018;315(4):H802–13. 10.1152/ajpheart.00093.2018.Search in Google Scholar PubMed

[40] Zhu M, Wang H, Chen J, Zhu H. Sinomenine improve diabetic nephropathy by inhibiting fibrosis and regulating the JAK2/STAT3/SOCS1 pathway in streptozotocin-induced diabetic rats. Life Sci. 2021;265:118855. 10.1016/j.lfs.2020.118855.Search in Google Scholar PubMed

[41] Hu J, Fan X, Meng X, Wang Y, Liang Q, Luo G. Evidence for the involvement of JAK/STAT/SOCS pathway in the mechanism of Tangshen formula-treated diabetic nephropathy. Planta Med. 2014;80(8–9):614–21. 10.1055/s-0034-1368454.Search in Google Scholar PubMed

[42] Deutsch E, Maggiorella L, Wen B, Bonnet ML, Khanfir K, Frascogna V, et al. Tyrosine kinase inhibitor AG1024 exerts antileukaemic effects on STI571-resistant Bcr-Abl expressing cells and decreases AKT phosphorylation. Br J Cancer. 2004;91(9):1735–41. 10.1038/sj.bjc.6602190.Search in Google Scholar PubMed PubMed Central

[43] Ligęza J, Ligęza J, Klein A. Growth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells. Acta Biochim Pol. 2011;58(3):391–6.10.18388/abp.2011_2252Search in Google Scholar

[44] O’Sullivan LA, Liongue C, Lewis RS, Stephenson SE, Ward AC. Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease. Mol Immunol. 2007;44(10):2497–506. 10.1016/j.molimm.2006.11.025.Search in Google Scholar PubMed

[45] Zhou Y, Lv C, Wu C, Chen F, Shao Y, Wang Q. Suppressor of cytokine signaling (SOCS) 2 attenuates renal lesions in rats with diabetic nephropathy. Acta Histochem. 2014;116(5):981–8. 10.1016/j.acthis.2014.04.002.Search in Google Scholar PubMed

[46] Shi Y, Du C, Zhang Y, Ren Y, Hao J, Zhao S, et al. Suppressor of cytokine signaling-1 ameliorates expression of MCP-1 in diabetic nephropathy. Am J Nephrol. 2010;31(5):380–8. 10.1159/000286559.Search in Google Scholar PubMed

Received: 2022-11-18
Revised: 2023-02-22
Accepted: 2023-03-02
Published Online: 2023-04-06

© 2023 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  241. Does total hip arthroplasty result in intercostal nerve injury? A case report and literature review
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  246. Anesthetic management of fetal pulmonary valvuloplasty: A case report
  247. Rapid Communication
  248. Impact of COVID-19 lockdown on glycemic levels during pregnancy: A retrospective analysis
  249. Erratum
  250. Erratum to “Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway”
  251. Erratum to: “Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p”
  252. Retraction
  253. Retraction of “Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients”
  254. Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
  255. Retraction of “miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells”
  256. Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”
  257. Retraction of “circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury”
  258. Retraction of “lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells”
  259. Special issue Linking Pathobiological Mechanisms to Clinical Application for cardiovascular diseases
  260. Effect of cardiac rehabilitation therapy on depressed patients with cardiac insufficiency after cardiac surgery
  261. Special issue The evolving saga of RNAs from bench to bedside - Part I
  262. FBLIM1 mRNA is a novel prognostic biomarker and is associated with immune infiltrates in glioma
  263. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part III
  264. Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer
https://doi.org/10.1515/med-2023-0683
Keywords for this article
diabetic nephropathy; IGF-1 receptor; AG1024; fibrosis; inflammation; SOCS
Creative Commons
BY 4.0

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  249. Erratum
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  251. Erratum to: “Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p”
  252. Retraction
  253. Retraction of “Study to compare the effect of casirivimab and imdevimab, remdesivir, and favipiravir on progression and multi-organ function of hospitalized COVID-19 patients”
  254. Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
  255. Retraction of “miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells”
  256. Retraction of “SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis”
  257. Retraction of “circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury”
  258. Retraction of “lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells”
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  261. Special issue The evolving saga of RNAs from bench to bedside - Part I
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  263. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part III
  264. Development of a machine learning-based signature utilizing inflammatory response genes for predicting prognosis and immune microenvironment in ovarian cancer
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