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A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis

  • Xianwei Chen , Yuqi Yang , Dongqi Li , En Ye , Bingjian He , Mingshu Yu , Jiankai Luo and Jing Zhang ORCID logo EMAIL logo
Published/Copyright: August 7, 2025
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Open Medicine
From the journal Open Medicine Volume 20 Issue 1

Abstract

Background

Ewing’s sarcoma (EWS) is a highly aggressive malignant tumor that originates from bone or soft tissue. To date, there is no established prognostic model for EWS tumor. This study aims to identify prognostic genes and develop a predictive model associated with fatty acid metabolism in EWS using bioinformatics analysis.

Results

We analyzed the GSE17679 dataset and identified 25 differentially expressed genes related to fatty acid metabolism in EWS. A risk model composed of ACADM, ADH5, ACSL1, ELOVL4, ECI1, PPT1, and ACOT7 gene signatures was constructed. The AUC values at 3 and 5 years were both ≥0.7, indicating good predictive accuracy. GSVA analysis revealed significant differences in fatty acid metabolism pathway enrichment between high- and low-risk groups. Differential genes were primarily enriched in pathways such as fatty acid oxidation, lipid oxidation, lipid modification, and fatty acid degradation. Immune infiltration analysis showed significant differences in memory B cells, activated NK cells, and neutrophils between the two groups. Additionally, significant differences were observed in the expression of immune checkpoints such as HAVCR2 and LDHB. Immunohistochemistry and survival analysis further demonstrated that the expression of PPT1 and ACOT7 proteins was associated with the progression-free survival of EWS patients.

Conclusions

We successfully constructed a prognostic model for EWS related to fatty acid metabolism genes. PPT1 and ACOT7 may serve as promising predictors for EWS prognosis.

Keywords: Ewing’s sarcoma; fatty acid metabolism; bioinformatics; biomarker; prognosis model; immune infiltration

1 Introduction

Ewing’s sarcoma (EWS) is the second most common primary bone tumor in children and adolescents, often originating in soft tissue. It is an extremely aggressive cancer, with a survival rate of 70–80% for patients with localized disease, but less than 30% for those with metastatic disease [1]. Over the past two decades, EWS survival rates have remained largely stagnant worldwide due to the lack of effective therapies [2,3]. In fact, most EWS patients already have micrometastases at the time of diagnosis. According to the WHO classification of bone tumors (2020), EWS is categorized as a small round cell sarcoma, primarily characterized by different EWS gene (EWSR1) fusions on chromosome 22q12 [4]. Although numerous biomarkers have been identified in EWS [5], the metastatic mechanisms of EWS remain unclear. Therefore, establishing a systematic prognostic model to predict EWS metastases is crucial for guiding early diagnosis and treatment.

While EWSR1-FLI1 is the driver gene of EWS oncogenesis, its expression often fails to predict EWS metastases due to influences from epigenetics, metabolomics, and other factors [6]. Cancer cells can often regulate their metabolism through multiple pathways. Compared to normal cells, cancer cells seem to be more likely to utilize energy through glycolysis and abnormal fatty acid metabolism due to the imbalance of the tricarboxylic acid cycle [1]. Recently, studies have demonstrated significant alterations in fatty acid metabolism in tumor cells [2,7]. Cancer cells rely on fatty acids as essential materials for cell synthesis, including cell membrane production, energy storage, and the synthesis of signaling molecules [3,8]. Fatty acid metabolism has been shown to be associated with prognosis in patients with rhabdomyosarcoma, breast cancer, lung cancer, and colon cancer [9,10,11,12]. A recent study also indicated that increased lipid peroxidation could lead to changes in S-phase progression and apoptosis in EWS cells [13]. These findings suggest that fatty acid metabolism may play a vital role in EWS tumor metastasis.

Therefore, leveraging public databases and bioinformatics approaches, this study comprehensively analyzed the prognostic value and potential mechanisms of fatty acid metabolism genes in EWS. The findings were further validated using immunohistochemical assays. This study provides a novel tool for predicting the prognosis of EWS patients and lays the groundwork for future research into the molecular mechanisms of fatty acid metabolism in EWS.

2 Research methods

2.1 Data construction, evaluation, and validation of the fatty acid metabolism-related gene (FAMG) risk model for EWS

We use EWS GSE17679 from the GEO database as a training set and the ICGC (BOCA-FR) as a testing set. A total of 92 FAMGs were obtained from the literature. Eighty-three FAMGs were detected in the GSE17679 dataset. Then, differentially expressed FAMGs (DE-FAMGs) were analyzed by the Limma R package (version 4.2) [4]. We set |log2FC| > 1 and P < 0.05. The FAMGs significantly associated with overall survival in EWS were identified using univariate Cox regression analysis (P < 0.05). These genes were included in the subsequent LASSO analysis. Next, we constructed the risk model by risk score (from multivariate Cox analysis). Patients were classified into two groups based on the median risk score. Kaplan–Meier survival analysis was used to compare survival outcomes between these groups. The predictive accuracy of the risk score model for overall survival in EWS patients was evaluated using time-dependent ROC curves.

2.2 Analysis of differential genes between high- and low-risk groups, GO and KEGG enrichment, and protein–protein interaction (PPI) network

High and low groups differentially expressed genes (DEGs) by “Limma” [4]. |log2FC| > 1 and P < 0.05 were set, and enrichment analysis was performed (clusterProfiler) [5]. The STRING V11.5 website was employed for PPI analysis (https://cn.string-db.org).

2.3 Analysis of immune infiltration and immune checkpoints in high- and low-risk groups

The EWSTIMATE algorithm was applied to infer infiltrating stromal cells and immune cells [6]. CIBERSORT [7] was used to predict differences in the levels of infiltrating immune cells. GSVA was used to quantify the enrichment scores of KEGG pathways and immune risk genes in various immune-related gene sets [8]. Subsequently, we analyzed the expression of immune checkpoints.

2.4 Immunohistochemistry

A total of 27 paraffin-embedded EWS tissue specimens were collected between May 2009 and June 2022 for immunohistochemical staining (Approval Number: KYLX2023-074). All patients were histologically diagnosed at Yunnan Cancer Hospital (Table 1). The follow-up time for patients ranged from 3 to 165 months (median: 22 months). We reviewed the relevant literature of seven genes (PPT1, ACADM, ADH5, ACOT7, ACSL1, ELOVL4, and ECI1) and selected five genes (PPT1, ACADM, ACOT7, ACSL1, and ECI1) that can obtain antibodies (Table S1) with high clinical application values. The tissue was fixed overnight, dehydrated, and embedded, and an immunohistochemical section was performed on 4 μm-thick sections. Using the SP immunohistochemistry two-step method, the sections were dewaxed, hydrated, subjected to antigen repair, and incubated. The sections were blocked with endogenous peroxidase and then washed. All antibodies were diluted according to the instructions. Digital pathological sections were scanned, and two experienced pathologists, blinded to the sample origins and patient outcomes, independently assessed each section. At least five high visual fields were observed, and the final immunoreactivity score (the intensity score * the extent score of stained cells) was calculated according to the German semiquantitative scoring system [9].

Table 1

General clinical data of 27 EWS patients

Clinicopathological characteristics ACOT7 P PPT1 P
≥6 <6 ≥6 <6
Sex
Male 8 5 7 6
Female 7 7 0.42 9 5 0.44
Age
<18 7 3 5 5
≥18 8 9 0.23 11 6 0.36
Enneking stage
II 10 8 12 6
III 5 4 0.66 4 5 0.24
Location
Limbs 8 7 11 4
Trunk 3 2 2 3
Pelvis 4 3 1.00 3 4 0.32

  1. Ethics and Consent: We obtained approval from the Ethics Committee of the Third Affiliated Hospital of Kunming Medical University (KYLX2023-074) on 2023-04-21.We have applied for exemption from signing the informed consent form when approved by the ethics committee.

3 Results

3.1 Construction, evaluation, and validation of the EWS FAMG risk model

Using univariate Cox regression, LASSO regression, and multivariate Cox regression, a prognostic model based on seven markers was constructed. A total of 25 DE-FAMGs were identified, comprising 11 upregulated and 14 downregulated genes (Figure 1a, Table S2). In total, 13 genes associated with prognosis were screened (Figure 1b) and included in the LASSO analysis. In the LASSO analysis, 13 genes were included in the penalty. As the penalty coefficient lambda was varied, an increasing number of variable coefficients were compressed to zero. The lambda.min = 0.076 obtained the best performance, and lambda.Lse = 0.146 was selected as a simpler model without significantly reducing the model performance (Figure 1c and d). Finally, nine genes were selected and included in the multivariate Cox analysis. As shown in Figure 1e, seven genes related to prognosis (P < 0.05) were PPT1, ACADM, ADH5, ACOT7, ACSL1, ELOVL4, and ECI1. The results showed that prognosis was significantly better in the low-risk score group than in the high one in the training (P < 0.001, Figure 2a) and testing sets (P < 0.001, Figure 2d). We evaluated the model using the ROC curves. The results showed that both the AUC values at 3 and 5 years were ≥0.7, indicating a decent precision accuracy (Figure 2b, c, e and f).

Figure 1 Construction of an FAMG risk model of EWS. (a) Heatmap of 25 differentially expressed fatty acid metabolism genes in tumors and normal tissues. (b) Thirteen genes were screened by univariate Cox regression analysis from FAMGs. (c) and (d) Nine genes were selected by LASSO analysis. (e) A prognostic model for seven genes was constructed by multivariate Cox regression analysis from FAMGs.
Figure 1

Construction of an FAMG risk model of EWS. (a) Heatmap of 25 differentially expressed fatty acid metabolism genes in tumors and normal tissues. (b) Thirteen genes were screened by univariate Cox regression analysis from FAMGs. (c) and (d) Nine genes were selected by LASSO analysis. (e) A prognostic model for seven genes was constructed by multivariate Cox regression analysis from FAMGs.

Figure 2 Survival analysis and ROC curves for training and testing sets. (a) Survival curves of the high- and low-risk score groups of the training sets. (b) and (c) ROC curves at 3 and 5 years for the risk model of training sets. (d) Survival curves of the high- and low-risk score groups of the testing sets. (e) and (f) ROC curves at 3 and 5 years for the risk model of the testing sets.
Figure 2

Survival analysis and ROC curves for training and testing sets. (a) Survival curves of the high- and low-risk score groups of the training sets. (b) and (c) ROC curves at 3 and 5 years for the risk model of training sets. (d) Survival curves of the high- and low-risk score groups of the testing sets. (e) and (f) ROC curves at 3 and 5 years for the risk model of the testing sets.

3.2 Enrichment analysis on DEGs between the high- and low-risk groups

It has a good prognosis in the training and testing databases. A total of 38 DEGs were identified between the two groups (Figure 3a), including 18 upregulated and 20 downregulated genes. Gene Ontology (GO) enrichment analysis revealed that these genes were involved in processes such as fatty acid metabolism, small molecule catabolism, fatty acid oxidation, lipid oxidation, lipid modification, cellular lipid catabolism, and the mitochondrial matrix (Figure 3b). KEGG enrichment analysis indicated that the DEGs were significantly enriched in pathways related to fatty acid degradation and the degradation of valine, leucine, and isoleucine (Figure 3c). To further understand the linkage of these 38 DEGs, we constructed a PPI network. In this network, 25 proteins encoded by differential genes interacted, including 95 edges (Figure 3d). Among the seven prognostic models that we constructed, ACADM, ADH5, ACSL1, ELOVL4, and ECI1 play a key role in the PPI network.

Figure 3 DEGs between the high- and low-risk groups. (a) Heatmap of DEGs between the high- and low-risk groups. (b) GO enrichment analysis in the high- and low-risk groups. (c) KEGG enrichment analysis in the high- and low-risk groups. (d) PPI network of the differential genes between the high- and low-risk groups.
Figure 3

DEGs between the high- and low-risk groups. (a) Heatmap of DEGs between the high- and low-risk groups. (b) GO enrichment analysis in the high- and low-risk groups. (c) KEGG enrichment analysis in the high- and low-risk groups. (d) PPI network of the differential genes between the high- and low-risk groups.

3.3 Different immune infiltration and immune checkpoints in the two groups

The high- and low-risk groups exhibit differences in the immune microenvironment. First, using the GSVA algorithm (Figure 4a), we found that there were significant differences in the enrichment of fatty acid metabolism pathways. The results indicated no significant difference in the stromal score, EWSTIMATE score, and tumor purity, except for the immune score of EWS patients (Figure 4b–e). CIBERSORT analysis revealed differences in the memory B cells, plasma cells, resting memory CD4 T cells, resting NK cells, activated NK cells, and neutrophils (Figure 4f). The functional analysis showed that there was a difference in T-cell costimulation-related functions (Figure 4g). Subsequently, the expression of immune checkpoints was analyzed, and it was found that there were differences in CD40, CD40LG, CD8A, CTLA4, FGL1, HAVCR2, JAK1, LDHB, and TNFRSF18, suggesting immunotherapy binding sites (Figure 4h).

Figure 4 Analysis of immune infiltration and immune checkpoints in the high- and low-risk groups. (a) GSVA of each KEGG pathway in the high- and low-risk groups. (b)–(e) EWSTIMATE score, immune score, stromal score, and tumor purity of the high- and low-risk groups. (f) Immune cell infiltration analysis of the high- and low-risk groups. (g) Functional analysis of the high- and low-risk groups. (h) Immune checkpoint expression analysis of the high- and low-risk groups.
Figure 4

Analysis of immune infiltration and immune checkpoints in the high- and low-risk groups. (a) GSVA of each KEGG pathway in the high- and low-risk groups. (b)–(e) EWSTIMATE score, immune score, stromal score, and tumor purity of the high- and low-risk groups. (f) Immune cell infiltration analysis of the high- and low-risk groups. (g) Functional analysis of the high- and low-risk groups. (h) Immune checkpoint expression analysis of the high- and low-risk groups.

3.4 Expression levels of PPT1 and ACOT7 are associated with the survival of EWS patients

Combining the experiment and clinical information, the correlation between key markers and prognosis was verified. As shown in Figure 5a and b, the ACOT7 and PPT1 proteins were widely expressed in EWS tumor cells with strong cytoplasmic and nuclear staining; the remaining proteins (ACADM, ACSL1, and ECI1) are shown in Figure S2. To evaluate the relationship between ACOT7 and PPT1 expression levels and clinicopathological features, EWS specimens were divided into high-expression groups (n = 15 for ACOT7, n = 16 for PPT1) and low-expression groups (n = 12 for ACOT7, n = 11 for PPT1). The high ACOT7 expression levels were significantly associated with shorter PFS time (P = 0.0239; Figure 5d). The patients with low PPT1 expression levels were significantly associated with a shorter PFS time (P = 0.0381; Figure 5c). Cox regression analysis identified ACOT7 (P = 0.004) and PPT1 (P = 0.020) expression as independent prognostic indicators for PFS of EWS patients (Table 2). Subsequently, we validated the key markers in the GEO dataset GSE17674 (Figure S1).

Figure 5 Immunohistochemical validation and statistical analysis of PPT1 and ACOT7. (a) PPT1 expression at magnifications of ×100 and ×400. (b) ACOT7 expression at magnifications of ×100 and ×400. (c) High expression of PPT1 was associated with a longer PFS time in patients with EWS (P = 0.0381). (d) Low expression of ACOT7 was associated with a longer PFS time in patients with EWS (P = 0.0239).
Figure 5

Immunohistochemical validation and statistical analysis of PPT1 and ACOT7. (a) PPT1 expression at magnifications of ×100 and ×400. (b) ACOT7 expression at magnifications of ×100 and ×400. (c) High expression of PPT1 was associated with a longer PFS time in patients with EWS (P = 0.0381). (d) Low expression of ACOT7 was associated with a longer PFS time in patients with EWS (P = 0.0239).

Table 2

Multivariate Cox regression analysis based on the patient’s basic information

Variable Multivariate Cox analysis
HR 95%CI P
Sex
Male 0.996 0.395–2.509 0.993
Female
Age
<18 0.703 0.236–2.096 0.527
≥18
Enneking stage
IIB, IIC 4.318 1.256–14.846 0.020
III
Location
Limbs 1.103 0.294–4.139 0.885
Trunk 0.578 0.181–1.850 0.356
Pelvis
PPT1 expression
High 0.284 0.098–0.823 0.020
Low
ACOT7 expression
High 5.796 1.778–18.891 0.004
Low

4 Discussion

The treatment of EWS has not progressed for a long time. Recently, FAM has become an emerging target in cancer treatment. The growth of tumor tissue requires a large amount of energy consumption. By regulating FAM, tumor tissue can change its metabolism to meet this energy demand. Therefore, we hope to find the key target for regulating FAM in EWS and inhibiting tumor progression. We conducted bioinformatics analysis based on public data of EWS and FAMGs and screened seven DE-FAMGs in EWS with prognostic values. By collecting postoperative pathological sections from patients in our hospital and following up on patients, and performing statistical analysis of relevant data, immunohistochemical verification of the tumor tissues of patients and survival analysis, we selected two biomarkers related to the clinical prognosis of tumors, filling the gap in early treatment and prognosis judgement for EWS.

We found that ACOT7 and PPT1 are closely related to patient PFS by immunohistochemistry and correlation statistical analysis of EWS tissue. At present, many studies have shown that the genes we mentioned above participate in the pathogenesis of tumors by affecting lipid metabolism, but there is no relevant research in EWS. The disorder of fatty acid metabolism is considered a part of the malignant transformation in many different cancers [10,11]. Acyl coenzyme A thioesters (ACOT7) are the main subtype of the acyl coenzyme family, which can catalyse the hydrolysis of acyl-CoA to free fatty acids and coenzyme A without esterification. ACOT7 plays an important role in lipid metabolism [12,13,14]. ACOT7 plays a role in immune cell infiltration and is closely associated with the cancer immune microenvironment [15]. Some studies [14] have shown that ACOT7 can enhance the proliferation and migration of hepatocytes by increasing the content of C18:1 monounsaturated fatty acids. A study on lung cancer suggested that ACOT7 metabolites may influence cancer prognosis by mediating changes in fatty acid metabolism through endoplasmic reticulum stress [12]. Microarray analysis related to malignant melanoma also reported that tumor progression was related to the high expression of ACOT7 [16]. Methylated ACOT7 may play a role in tumor inhibition [17]. Overexpression of ACOT7 promotes the production of the monounsaturated fatty acid oleic acid, which enhances the proliferation and migration of liver cancer cells. [14]. Reports show that ACOT7 can inhibit lipid peroxidation by inhibiting ferroptosis [18]. Lysosomes play a dual role in cancer metabolism by facilitating catabolic processes such as autophagy and macropinocytosis while also promoting mTORC1-dependent anabolism. Palmitoyl protein thioesterase 1 (PPT1), a lysosomal enzyme, is overexpressed in various tumors and is associated with poor survival. However, this finding is inconsistent with our results (Figure 5c). This may be related to the fact that targeting PPT1 can block mTOR signal transduction while inhibiting autophagy and can be used as a target treatment [19]. Currently, the mechanism of action of ACOT7 and PPT1 in EWS has not been reported. We found for the first time that ACOT7 and PPT1 might be prognostic biomarkers in patients with EWS, and they are closely related to survival prognosis. Further experimental research and clinical validation are needed to understand how these factors influence fatty acid metabolism during the development and progression of EWS and their impact on patient prognosis.

The enrichment analysis results are consistent with the report of Buchou et al., indicating that FAMGs may be related to the modification of EWSR1 [20]. Immune infiltration and immune checkpoint analysis of the two groups were performed. Our analysis revealed significant differences in the memory B cells, activated NK cells, and neutrophils between the two groups. Research suggests that obesity can drive lipid accumulation in NK cells through the peroxisome proliferator-activated receptor (PPAR), resulting in the metabolic and functional “paralysis” of these cells. This impairs their ability to mount an effective antitumor response [21]. There have also been reports of NK cell-related fatty acid metabolism abnormalities leading to tumor progression in lung adenocarcinoma and lymphoma [22,23]. This may be related to the change in the tumor microenvironment (TME), leading to immune resistance [24]. Research has reported that when glucose utilization is restricted, tumor-induced oxidative neutrophils can maintain ROS production and inhibit T cells, leading to tumor development [25]. HAVCR2, LDHB, and TNFRSF18 have been a research basis for immune checkpoints. Studies have shown that an increase in glycolysis leads to the accumulation of lactic acid in cells, forming an acidic environment. This inhibits the activity of CD4 T cells and promotes the development of tumors. Therefore, overexpression of LDHB may represent a promising strategy to enhance the effectiveness of adoptive T-cell transfer therapy [26]. The genes HAVCR2 and TIM-3 (t cell immunoglobulin domain and mucin domain 3, CD366) have been shown to be coexpressed with PD-1. Their high expression may block the adaptive resistance of PD-1 to promote tumor progression, while blocking the TIM-3 and PD-1 pathways significantly inhibits tumor growth [27]. Some studies have shown that TNFRSF18 (glucocorticoid-induced tumor necrosis factor) can activate the MAPK/ERK and NF-kB pathways through the high-level expression of T-reg cells, thus leading to the production of proinflammatory cytokines and enhancing the antitumor effect [28]. However, the specific immune mechanisms underlying EWS remain unclear, highlighting the need for further investigation.

In this study, database analyses were conducted to identify FAMG targets that may influence the prognosis of EWS. However, due to the low prevalence of EWS, the database contains a small number of datasets and lacks a comprehensive multicenter, multidata set study. Further experimental validation is also lacking, and further research is needed. In subsequent research, it is necessary to increase the sample size and further study the mechanism. In addition, an increasing number of studies are exploring levels of tumors using Multiomics. We can also conduct research on EWS from other aspects such as single-cell and proteomics to understand the specific mechanisms of fatty acid metabolism in disease occurrence, development, and drug resistance.

5 Conclusions

In summary, we developed a prognostic model for EWS and identified two biological targets based on public databases and patient data from our hospital. Our study identifies new biological targets for predicting the prognosis of EWS patients, potentially aiding in clinical decision-making.

Abbreviations

EWS

Ewing’s sarcoma

GEO

Gene Expression Omnibus

ICGC

International Cancer Genome Consortium

ROS

Reactive oxygen species

FAMGs

Fatty acid metabolism-related genes

GO

Gene Ontology

KEGG

Kyoto Encyclopedia of Genes and Genomes

PPI

Protein–Protein interaction

GSVA

Gene set variation analysis

PPAR

Peroxisome proliferator-activated receptor

TME

Tumor microenvironment

# These authors contributed equally to this work.

tel: +86-13700615190

  1. Funding information: This research was funded by the Ten Thousand People Plan of Yunnan Province (grant number NWRQNBJ-2019-163). Applied Basic Research Foundation of Yunnan Province (grant number 202101AY070001-156).

  2. Author contributions: Jing Zhang: conceptualization, funding acquisition, project administration, and writing – review and editing. Xianwei Chen: software and writing – original draft. Yuqi Yang: data curation. Dongqi Li: writing – original draft. En Ye: methodology. Bingjian He: formal analysis. Mingshu Yu: methodology. Jiankai Luo: data curation.

  3. Conflict of interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.

  4. Data availability statement: The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Received: 2025-02-26
Revised: 2025-06-14
Accepted: 2025-06-16
Published Online: 2025-08-07

© 2025 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Articles in the same Issue

  1. Research Articles
  2. Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
  3. Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
  4. Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
  5. Risk factors for severe adverse drug reactions in hospitalized patients
  6. Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
  7. Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
  8. CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
  9. Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
  10. Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
  11. Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
  12. Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
  13. Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
  14. Association between statin administration and outcome in patients with sepsis: A retrospective study
  15. Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
  16. A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
  17. Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
  18. Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
  19. Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
  20. Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
  21. Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
  22. The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
  23. Health literacy and health-related quality of life: The mediating role of irrational happiness
  24. Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
  25. Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
  26. Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
  27. Clinical analysis of ten cases of HIV infection combined with acute leukemia
  28. Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
  29. Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
  30. Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
  31. Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
  32. Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
  33. The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
  34. The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
  35. Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
  36. Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
  37. Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
  38. The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
  39. Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
  40. A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
  41. A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  42. Identifying early screening factors for depression in middle-aged and older adults: A cohort study
  43. Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
  44. Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
  45. High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
  46. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Investigation of the pathogenic variants induced Sjogren’s syndrome in Turkish population
  128. Nucleotide metabolic abnormalities in post-COVID-19 condition and type 2 diabetes mellitus patients and their association with endocrine dysfunction
  129. TGF-β–Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization
  130. Ultrasound-guided unilateral versus bilateral erector spinae plane block for postoperative analgesia of patients undergoing laparoscopic cholecystectomy
  131. Profiling gut microbiome dynamics in subacute thyroiditis: Implications for pathogenesis, diagnosis, and treatment
  132. Delta neutrophil index, CRP/albumin ratio, procalcitonin, immature granulocytes, and HALP score in acute appendicitis: Best performing biomarker?
  133. Anticancer activity mechanism of novelly synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative on colon cancer cells
  134. H2valdien3 arrests the cell cycle and induces apoptosis of gastric cancer
  135. Prognostic relevance of PRSS2 and its immune correlates in papillary thyroid carcinoma
  136. Association of SGLT2 inhibition with psychiatric disorders: A Mendelian randomization study
  137. Motivational interviewing for alcohol use reduction in Thai patients
  138. Luteolin alleviates oxygen-glucose deprivation/reoxygenation-induced neuron injury by regulating NLRP3/IL-1β signaling
  139. Polyphyllin II inhibits thyroid cancer cell growth by simultaneously inhibiting glycolysis and oxidative phosphorylation
  140. Relationship between the expression of copper death promoting factor SLC31A1 in papillary thyroid carcinoma and clinicopathological indicators and prognosis
  141. CSF2 polarized neutrophils and invaded renal cancer cells in vitro influence
  142. Proton pump inhibitors-induced thrombocytopenia: A systematic literature analysis of case reports
  143. The current status and influence factors of research ability among community nurses: A sequential qualitative–quantitative study
  144. OKAIN: A comprehensive oncology knowledge base for the interpretation of clinically actionable alterations
  145. The relationship between serum CA50, CA242, and SAA levels and clinical pathological characteristics and prognosis in patients with pancreatic cancer
  146. Identification and external validation of a prognostic signature based on hypoxia–glycolysis-related genes for kidney renal clear cell carcinoma
  147. Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility
  148. Relationship of resting echocardiography combined with serum micronutrients to the severity of low-gradient severe aortic stenosis
  149. Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial
  150. The diagnostic performance of machine learning-based FFRCT for coronary artery disease: A meta-analysis
  151. Comparing biofeedback device vs diaphragmatic breathing for bloating relief: A randomized controlled trial
  152. Serum uric acid to albumin ratio and C-reactive protein as predictive biomarkers for chronic total occlusion and coronary collateral circulation quality
  153. Multiple organ scoring systems for predicting in-hospital mortality of sepsis patients in the intensive care unit
  154. Single-cell RNA sequencing data analysis of the inner ear in gentamicin-treated mice via intraperitoneal injection
  155. Review Articles
  156. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  157. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  158. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  159. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  160. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  161. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  162. The application of augmented reality in robotic general surgery: A mini-review
  163. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  164. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  165. Plant polyphenols, terpenes, and terpenoids in oral health
  166. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  167. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  168. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  169. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  170. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  171. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  172. Giant borderline ovarian tumours – review of the literature
  173. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  174. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  175. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  176. Supplement strategies for infertility in overweight women: Evidence and legal insights
  177. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  178. A meta-analysis of the effects of DBS on cognitive function in patients with advanced PD
  179. Protective role of selenium in sepsis: Mechanisms and potential therapeutic strategies
  180. Strategies for hyperkalemia management in dialysis patients: A systematic review
  181. C-reactive protein-to-albumin ratio in peripheral artery disease
  182. Case Reports
  183. Delayed graft function after renal transplantation
  184. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  185. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  186. Giant right atrial hemangioma presenting with ascites: A case report
  187. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  188. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  189. Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report
  190. Coronary artery anomalies: A case of the “malignant” left coronary artery and its surgical management
  191. Rapid Communication
  192. Biological properties of valve materials using RGD and EC
  193. A single oral administration of flavanols enhances short-term memory in mice along with increased brain-derived neurotrophic factor
  194. Letter to the Editor
  195. Role of enhanced external counterpulsation in long COVID
  196. Expression of Concern
  197. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  198. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  199. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  200. Corrigendum
  201. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  202. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  203. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  204. Retraction
  205. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  206. Retraction of: “LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through downregulating SP-A by sponging to miR-424”
  207. Retraction of: “SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways”
  208. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  209. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  210. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  211. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  212. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  213. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  214. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  215. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  216. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  217. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  218. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  219. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  220. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  221. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  222. Red cell distribution width predicts early kidney injury: A NHANES cross-sectional study
  223. Special Issue Diabetes mellitus: pathophysiology, complications & treatment
  224. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  225. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  226. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  227. A review of brain research on T2DM-related cognitive dysfunction
  228. Metformin and estrogen modulation in LABC with T2DM: A 36-month randomized trial
  229. Special Issue Innovative Biomarker Discovery and Precision Medicine in Cancer Diagnostics
  230. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
https://doi.org/10.1515/med-2025-1238
Keywords for this article
Ewing’s sarcoma; fatty acid metabolism; bioinformatics; biomarker; prognosis model; immune infiltration
Creative Commons
BY 4.0

Articles in the same Issue

  1. Research Articles
  2. Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
  3. Impact of diabetes on long-term survival in elderly liver cancer patients: A retrospective study
  4. Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway
  5. Risk factors for severe adverse drug reactions in hospitalized patients
  6. Analysis of the effect of ALA-PDT on macrophages in footpad model of mice infected with Fonsecaea monophora based on single-cell sequencing
  7. Development and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor
  8. CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis
  9. Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
  10. Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
  11. Comparison of the effectiveness of nurse-led preoperative counseling and postoperative follow-up care vs standard care for patients with gastric cancer
  12. Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis
  13. Adhered macrophages as an additional marker of cardiomyocyte injury in biopsies of patients with dilated cardiomyopathy
  14. Association between statin administration and outcome in patients with sepsis: A retrospective study
  15. Exploration of the association between estimated glucose disposal rate and osteoarthritis in middle-aged and older adults: An analysis of NHANES data from 2011 to 2018
  16. A comparative analysis of the binary and multiclass classified chest X-ray images of pneumonia and COVID-19 with ML and DL models
  17. Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function
  18. Transcription factor A, mitochondrial promotes lymph node metastasis and lymphangiogenesis in epithelial ovarian carcinoma
  19. Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition
  20. Hydromorphone reduced the incidence of emergence agitation after adenotonsillectomy in children with obstructive sleep apnea: A randomized, double-blind study
  21. Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome
  22. The first-line antihypertensive nitrendipine potentiated the therapeutic effect of oxaliplatin by downregulating CACNA1D in colorectal cancer
  23. Health literacy and health-related quality of life: The mediating role of irrational happiness
  24. Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis
  25. Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics
  26. Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
  27. Clinical analysis of ten cases of HIV infection combined with acute leukemia
  28. Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights
  29. Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis
  30. Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection
  31. Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
  32. Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women
  33. The ERAS nursing care strategy for patients undergoing transsphenoidal endoscopic pituitary tumor resection: A randomized blinded controlled trial
  34. The serum IL-17A levels in patients with traumatic bowel rupture post-surgery and its predictive value for patient prognosis
  35. Impact of Kolb’s experiential learning theory-based nursing on caregiver burden and psychological state of caregivers of dementia patients
  36. Analysis of serum NLR combined with intraoperative margin condition to predict the prognosis of cervical HSIL patients undergoing LEEP surgery
  37. Commiphora gileadensis ameliorate infertility and erectile dysfunction in diabetic male mice
  38. The correlation between epithelial–mesenchymal transition classification and MMP2 expression of circulating tumor cells and prognosis of advanced or metastatic nasopharyngeal carcinoma
  39. Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway
  40. A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients
  41. A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue
  42. Identifying early screening factors for depression in middle-aged and older adults: A cohort study
  43. Perform tumor-specific survival analysis for Merkel cell carcinoma patients undergoing surgical resection based on the SEER database by constructing a nomogram chart
  44. Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator
  45. High-dose preoperative intraperitoneal erythropoietin and intravenous methylprednisolone in acute traumatic spinal cord injuries following decompression surgeries
  46. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
  47. Impact of peripheral conditioning on reperfusion injury following primary percutaneous coronary intervention in diabetic and non-diabetic STEMI patients
  48. Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study
  49. The effect of ambulatory blood pressure load on mitral regurgitation in continuous ambulatory peritoneal dialysis patients
  50. Expression and clinical significance of ITGA3 in breast cancer
  51. Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
  52. rSIG combined with NLR in the prognostic assessment of patients with multiple injuries
  53. Toxic metals and metalloids in collagen supplements of fish and jellyfish origin: Risk assessment for daily intake
  54. Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study
  55. Gender beliefs and legitimization of dating violence in adolescents
  56. Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
  57. Effect of smoking and smoking cessation on hematological parameters in polycythemic patients
  58. Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study
  59. Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway
  60. Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway
  61. Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
  62. GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma
  63. Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study
  64. MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration
  65. Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma
  66. Trends in research on preterm birth in twin pregnancy based on bibliometrics
  67. Four-week IgE/baseline IgE ratio combined with tryptase predicts clinical outcome in omalizumab-treated children with moderate-to-severe asthma
  68. Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype
  69. Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
  70. Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients
  71. Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3
  72. CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients
  73. Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study
  74. Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models
  75. Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study
  76. Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina
  77. Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture
  78. Factors associated with maternal attention and distraction during breastfeeding and childcare: A cross-sectional study in the west of Iran
  79. Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
  80. The law on oncological oblivion in the Italian and European context: How to best uphold the cancer patients’ rights to privacy and self-determination?
  81. The prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and prognostic nutritional index for survival in patients with colorectal cancer
  82. Factors affecting the measurements of peripheral oxygen saturation values in healthy young adults
  83. Comparison and correlations between findings of hysteroscopy and vaginal color Doppler ultrasonography for detection of uterine abnormalities in patients with recurrent implantation failure
  84. The effects of different types of RAGT on balance function in stroke patients with low levels of independent walking in a convalescent rehabilitation hospital
  85. Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study
  86. Correlations of health literacy with individuals’ understanding and use of medications in Southern Taiwan
  87. Correlation of serum calprotectin with outcome of acute cerebral infarction
  88. Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
  89. Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation
  90. The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association
  91. Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance
  92. Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study
  93. Dexmedetomidine suppresses microglial activation in postoperative cognitive dysfunction via the mmu-miRNA-125/TRAF6 signaling axis
  94. Analysis of serum metabolomics in patients with different types of chronic heart failure
  95. Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
  96. Pachymaran alleviates fat accumulation, hepatocyte degeneration, and injury in mice with nonalcoholic fatty liver disease
  97. Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19
  98. METTL3 blocked the progression of diabetic retinopathy through m6A-modified SOX2
  99. The predictive significance of anti-RO-52 antibody in patients with interstitial pneumonia after treatment of malignant tumors
  100. Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization
  101. Development and validation of potential molecular subtypes and signatures of ocular sarcoidosis based on autophagy-related gene analysis
  102. Widespread venous thrombosis: Unveiling a complex case of Behçet’s disease with a literature perspective
  103. Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
  104. Discovery of lipid metabolism-related diagnostic biomarkers and construction of diagnostic model in steroid-induced osteonecrosis of femoral head
  105. Serum-derived exomiR-188-3p is a promising novel biomarker for early-stage ovarian cancer
  106. Enhancing chronic back pain management: A comparative study of ultrasound–MRI fusion guidance for paravertebral nerve block
  107. Peptide CCAT1-70aa promotes hepatocellular carcinoma proliferation and invasion via the MAPK/ERK pathway
  108. Electroacupuncture-induced reduction of myocardial ischemia–reperfusion injury via FTO-dependent m6A methylation modulation
  109. Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study
  110. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
  111. HALP score in Demodex blepharitis: A case–control study
  112. Assessment of SOX2 performance as a marker for circulating cancer stem-like cells (CCSCs) identification in advanced breast cancer patients using CytoTrack system
  113. Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study
  114. Comparison of the two intestinal anastomosis methods in pediatric patients
  115. Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer
  116. Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
  117. Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures
  118. Petunidin attenuates lipopolysaccharide-induced retinal microglia inflammatory response in diabetic retinopathy by targeting OGT/NF-κB/LCN2 axis
  119. Procalcitonin and C-reactive protein as biomarkers for diagnosing and assessing the severity of acute cholecystitis
  120. Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
  121. Development of a nomogram for predicting cancer-specific survival in patients with renal pelvic cancer following surgery
  122. Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force
  123. A machine learning-based prognostic model integrating mRNA stemness index, hypoxia, and glycolysis‑related biomarkers for colorectal cancer
  124. Glutathione attenuates sepsis-associated encephalopathy via dual modulation of NF-κB and PKA/CREB pathways
  125. FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway
  126. Association of placenta weight and morphology with term low birth weight: A case–control study
  127. Investigation of the pathogenic variants induced Sjogren’s syndrome in Turkish population
  128. Nucleotide metabolic abnormalities in post-COVID-19 condition and type 2 diabetes mellitus patients and their association with endocrine dysfunction
  129. TGF-β–Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization
  130. Ultrasound-guided unilateral versus bilateral erector spinae plane block for postoperative analgesia of patients undergoing laparoscopic cholecystectomy
  131. Profiling gut microbiome dynamics in subacute thyroiditis: Implications for pathogenesis, diagnosis, and treatment
  132. Delta neutrophil index, CRP/albumin ratio, procalcitonin, immature granulocytes, and HALP score in acute appendicitis: Best performing biomarker?
  133. Anticancer activity mechanism of novelly synthesized and characterized benzofuran ring-linked 3-nitrophenyl chalcone derivative on colon cancer cells
  134. H2valdien3 arrests the cell cycle and induces apoptosis of gastric cancer
  135. Prognostic relevance of PRSS2 and its immune correlates in papillary thyroid carcinoma
  136. Association of SGLT2 inhibition with psychiatric disorders: A Mendelian randomization study
  137. Motivational interviewing for alcohol use reduction in Thai patients
  138. Luteolin alleviates oxygen-glucose deprivation/reoxygenation-induced neuron injury by regulating NLRP3/IL-1β signaling
  139. Polyphyllin II inhibits thyroid cancer cell growth by simultaneously inhibiting glycolysis and oxidative phosphorylation
  140. Relationship between the expression of copper death promoting factor SLC31A1 in papillary thyroid carcinoma and clinicopathological indicators and prognosis
  141. CSF2 polarized neutrophils and invaded renal cancer cells in vitro influence
  142. Proton pump inhibitors-induced thrombocytopenia: A systematic literature analysis of case reports
  143. The current status and influence factors of research ability among community nurses: A sequential qualitative–quantitative study
  144. OKAIN: A comprehensive oncology knowledge base for the interpretation of clinically actionable alterations
  145. The relationship between serum CA50, CA242, and SAA levels and clinical pathological characteristics and prognosis in patients with pancreatic cancer
  146. Identification and external validation of a prognostic signature based on hypoxia–glycolysis-related genes for kidney renal clear cell carcinoma
  147. Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility
  148. Relationship of resting echocardiography combined with serum micronutrients to the severity of low-gradient severe aortic stenosis
  149. Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial
  150. The diagnostic performance of machine learning-based FFRCT for coronary artery disease: A meta-analysis
  151. Comparing biofeedback device vs diaphragmatic breathing for bloating relief: A randomized controlled trial
  152. Serum uric acid to albumin ratio and C-reactive protein as predictive biomarkers for chronic total occlusion and coronary collateral circulation quality
  153. Multiple organ scoring systems for predicting in-hospital mortality of sepsis patients in the intensive care unit
  154. Single-cell RNA sequencing data analysis of the inner ear in gentamicin-treated mice via intraperitoneal injection
  155. Review Articles
  156. The effects of enhanced external counter-pulsation on post-acute sequelae of COVID-19: A narrative review
  157. Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
  158. Microscopic changes and gross morphology of placenta in women affected by gestational diabetes mellitus in dietary treatment: A systematic review
  159. Review of mechanisms and frontier applications in IL-17A-induced hypertension
  160. Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus
  161. The safety and efficacy of BCG combined with mitomycin C compared with BCG monotherapy in patients with non-muscle-invasive bladder cancer: A systematic review and meta-analysis
  162. The application of augmented reality in robotic general surgery: A mini-review
  163. The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals
  164. Neurogasobiology of migraine: Carbon monoxide, hydrogen sulfide, and nitric oxide as emerging pathophysiological trinacrium relevant to nociception regulation
  165. Plant polyphenols, terpenes, and terpenoids in oral health
  166. Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective
  167. End-of-life in cancer patients: Medicolegal implications and ethical challenges in Europe
  168. The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review
  169. Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings
  170. PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
  171. Screening of Group B Streptococcus in pregnancy: A systematic review for the laboratory detection
  172. Giant borderline ovarian tumours – review of the literature
  173. Leveraging artificial intelligence for collaborative care planning: Innovations and impacts in shared decision-making – A systematic review
  174. Cholera epidemiology analysis through the experience of the 1973 Naples epidemic
  175. Risk factors of frailty/sarcopenia in community older adults: Meta-analysis
  176. Supplement strategies for infertility in overweight women: Evidence and legal insights
  177. Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review
  178. A meta-analysis of the effects of DBS on cognitive function in patients with advanced PD
  179. Protective role of selenium in sepsis: Mechanisms and potential therapeutic strategies
  180. Strategies for hyperkalemia management in dialysis patients: A systematic review
  181. C-reactive protein-to-albumin ratio in peripheral artery disease
  182. Case Reports
  183. Delayed graft function after renal transplantation
  184. Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature
  185. Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case
  186. Giant right atrial hemangioma presenting with ascites: A case report
  187. Laser excision of a large granular cell tumor of the vocal cord with subglottic extension: A case report
  188. EsoFLIP-assisted dilation for dysphagia in systemic sclerosis: Highlighting the role of multimodal esophageal evaluation
  189. Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report
  190. Coronary artery anomalies: A case of the “malignant” left coronary artery and its surgical management
  191. Rapid Communication
  192. Biological properties of valve materials using RGD and EC
  193. A single oral administration of flavanols enhances short-term memory in mice along with increased brain-derived neurotrophic factor
  194. Letter to the Editor
  195. Role of enhanced external counterpulsation in long COVID
  196. Expression of Concern
  197. Expression of concern “A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma”
  198. Expression of concern “Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway”
  199. Expression of concern “circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8”
  200. Corrigendum
  201. Corrigendum to “Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism”
  202. Corrigendum to “Comparing the therapeutic efficacy of endoscopic minimally invasive surgery and traditional surgery for early-stage breast cancer: A meta-analysis”
  203. Corrigendum to “The progress of autoimmune hepatitis research and future challenges”
  204. Retraction
  205. Retraction of “miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway”
  206. Retraction of: “LncRNA CASC15 inhibition relieves renal fibrosis in diabetic nephropathy through downregulating SP-A by sponging to miR-424”
  207. Retraction of: “SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways”
  208. Special Issue Advancements in oncology: bridging clinical and experimental research - Part II
  209. Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer
  210. Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells
  211. The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges
  212. Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ
  213. Meta-analysis of clinical efficacy and safety of immunotherapy combined with chemotherapy in non-small cell lung cancer
  214. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part IV
  215. Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development
  216. Special Issue The evolving saga of RNAs from bench to bedside - Part III
  217. Interaction and verification of ferroptosis-related RNAs Rela and Stat3 in promoting sepsis-associated acute kidney injury
  218. The mRNA MOXD1: Link to oxidative stress and prognostic significance in gastric cancer
  219. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part II
  220. Dynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke
  221. A prognostic model correlated with fatty acid metabolism in Ewing’s sarcoma based on bioinformatics analysis
  222. Red cell distribution width predicts early kidney injury: A NHANES cross-sectional study
  223. Special Issue Diabetes mellitus: pathophysiology, complications & treatment
  224. Nutritional risk assessment and nutritional support in children with congenital diabetes during surgery
  225. Correlation of the differential expressions of RANK, RANKL, and OPG with obesity in the elderly population in Xinjiang
  226. A discussion on the application of fluorescence micro-optical sectioning tomography in the research of cognitive dysfunction in diabetes
  227. A review of brain research on T2DM-related cognitive dysfunction
  228. Metformin and estrogen modulation in LABC with T2DM: A 36-month randomized trial
  229. Special Issue Innovative Biomarker Discovery and Precision Medicine in Cancer Diagnostics
  230. CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms
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