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Refractory hypertension complicated with Turner syndrome: A case report

  • Sisi Hu , Jichun Liu , Haixia Tang , Xiangrong Xie EMAIL logo and Youquan Wei EMAIL logo
Published/Copyright: August 6, 2024
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Open Life Sciences
From the journal Open Life Sciences Volume 19 Issue 1

Abstract

Hypertension is commonly classified into essential hypertension and secondary hypertension, although definitive classification can be challenging in some cases. Here, we discussed a patient who admitted for refractory hypertension, exhibiting various clinical manifestations including inadequate estrogen secretion, underdeveloped secondary sexual characteristics, primary amenorrhea, short stature, multiple moles, and somatic abnormalities. The patient was finally diagnosed with Turner syndrome (TS) based on clinical findings and chromosomal analysis. The genetic karyotype identified was 46,X,i(X)(q10).

Keywords: hypertension; Turner syndrome; sex chromosome disorder

1 Background

Turner syndrome (TS), also known as congenital ovarian dysgenesis, was first described by American endocrinologist Henry Turner in 1938. It is a chromosomal disorder characterized by complete or partial loss of one X chromosome in affected individuals. Its clinical manifestations include insufficient estrogen secretion, underdeveloped secondary sexual characteristics, primary amenorrhea, short stature, multiple moles, spinal deformities, and coarctation of the aorta [1]. Current data indicate an incidence of 1 in 2,000 live female births [2,3]. Individuals with TS face a threefold higher risk of cardiovascular diseases compared to the general population [4]. Hypertension emerges as a significant risk factor for acquired cardiovascular diseases, with females affected by TS prone to developing hypertension during childhood and adolescence. As reported by observational studies, the prevalence of hypertension among TS patients varied from 21 to 40%, increasing with age [5]. This report presented a rare case of refractory hypertension complicated by TS. Our study was aimed to explore the clinical characteristics, diagnostic challenges, and therapeutic strategies associated with this case, thereby enhancing understanding of this condition and providing a valuable reference for effective management for it.

2 Case presentation

On February 16, 2023, a 31-year-old female patient was admitted to the hospital due to a 1-day history of elevated blood pressure.

2.1 Medical history

The patient had visited the dental department a week before due to toothache resulting from dental caries. During this visit, her blood pressure was recorded as 220/120 mmHg, prompting the dentist to recommend consultation with the cardiology department. The patient reported transient dizziness and discomfort, with the first occurrence 3 months ago and a second occurrence 3 days ago. Although the patient did not consider these episodes significant, they were noteworthy. She denied any history of chronic illnesses. Despite being married for 5 years, she experienced irregular menstruation and remained nulliparous.

  1. Informed consent: Informed consent has been obtained from all individuals included in this study.

  2. Ethical approval: The research related to human use has been complied with all the relevant national regulations, institutional policies and in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.

2.2 Physical examination

Upon examination, her blood pressure in the right upper limb was observed to be 270/164 mmHg, and in the left upper limb, it was 262/158 mmHg. Her body mass index (BMI) was 25.33, with the weight of 54 kg and height of 146 cm, suggesting obesity according to standard BMI classifications. Coarse breath sounds were auscultated bilaterally, without the presence of crackles or wheezes. Her heart rate was 121 beats per minute, demonstrating a regular rhythm. No pathological murmurs were detected during auscultation of the cardiac valves. There was no edema observed in either lower limb.

2.3 Laboratory tests

The patient’s laboratory results indicated a potassium level of 2.71 mmol/L, creatinine of 145.7 µmol/L, urine protein of +++, anti-thyroglobulin antibody of 106.1 IU/mL, and thyroid peroxidase antibody of 131.4 IU/mL, suggesting hypokalemia, chronic renal insufficiency, and autoimmune thyroiditis. An electrocardiogram revealed sinus rhythm, left ventricular hypertrophy, and ST-T changes (Figure 1a). Cardiac ultrasound showed an ejection fraction of 58%, left atrium diameter of 42 mm, and left ventricle diameter of 43 mm, with normal valve morphology and closure. A head computed tomography (CT) indicated acute cerebral infarction (Figure 1b). Ambulatory blood pressure monitoring revealed a non-dipping pattern. The patient presented with hypertension and hypokalemia, and reported dental decay and toothache. Additionally, she experienced multiple episodes of vomiting following anesthesia rinsing before tooth extraction, suggesting that the hypokalemia may be secondary to vomiting. Oral potassium supplementation was promptly administered due to severe hypokalemia upon admission, and no 24 h urine potassium collection was performed. Further imaging studies, including adrenal and renal Doppler ultrasound, contrast-enhanced adrenal CT, and thoracoabdominal computed tomographic angiography (CTA), showed no significant abnormalities (Figure 1d).

Figure 1 (a) Electrocardiogram showing sinus rhythm, left ventricular hypertrophy, and ST-T changes. (b) Acute cerebral infarction. (c) Gynecological color Doppler ultrasound suggesting uterine size of 23, 13, 28 mm and bilateral adnexal linear changes. (d) Chest and abdominal CTA showing no abnormalities.
Figure 1

(a) Electrocardiogram showing sinus rhythm, left ventricular hypertrophy, and ST-T changes. (b) Acute cerebral infarction. (c) Gynecological color Doppler ultrasound suggesting uterine size of 23, 13, 28 mm and bilateral adnexal linear changes. (d) Chest and abdominal CTA showing no abnormalities.

2.4 Detailed findings

A comprehensive medical history and physical examination revealed the absence of secondary sexual characteristics, onset of menarche at 18 years old, irregular menstruation, 5 years of infertility, and previous gynecological examinations indicating a small uterus. Subsequent pelvic ultrasound showed a uterine size of 23 mm × 13 mm × 28 mm with bilateral adnexal changes (Figure 1c), suggesting possible premature ovarian failure. Further physical examination identified underdeveloped secondary sexual characteristics, short stature (146 cm), multiple moles, cubitus valgus, wide-set eyes, and ptosis (Figure 2). Hormonal analysis demonstrated decreased estradiol levels (14 pg/mL) and elevated follicle-stimulating hormone (FSH) (82.59 mIU/mL).

Figure 2 Multiple moles (a)–(d), webbed neck (c), and elbow pronation (d).
Figure 2

Multiple moles (a)–(d), webbed neck (c), and elbow pronation (d).

2.5 Discharge medications

The patient was discharged on the following medications: sacubitril valsartan sodium tablets 300 mg once daily, nifedipine sustained-release tablets 10 mg once daily, hydrochlorothiazide tablets 12.5 mg once daily, carvedilol 20 mg twice daily, enteric-coated aspirin tablets 0.1 g once daily, and atorvastatin calcium tablets 20 mg once nightly. During a follow-up visit 1 month later, an outpatient examination was conducted, which showed no presence of urinary protein detected and a creatinine level of 133 µmol/L.

3 Discussion

The patient was a young female diagnosed with hypertension, initially measured at 220/120 mmHg. Given her age and lack of risk factors for essential hypertension, secondary causes were thoroughly investigated. Auxiliary examinations revealed multi-organ damage involving the heart, brain, and kidneys, suggesting potential secondary hypertension. Additionally, she presented with hypokalemia, prompting consideration of secondary causes such as primary hyperaldosteronism. However, her renin level was elevated at 138.30 µIU/mL, and aldosterone was also elevated at 58.10 ng/dL, indicating secondary hyperaldosteronism. Further imaging studies, including adrenal and renal Doppler ultrasound and contrast-enhanced adrenal CT, showed no significant abnormalities. Thoracoabdominal CTA ruled out the possibilities of coarctation of the aorta, renal artery stenosis, renin-secreting tumors, and primary hyperaldosteronism as potential causes of secondary hypertension (Figure 3).

Figure 3 Karyotype: 46,X,i(X)(q10); the chromosome number: 46; the sex chromosome: X (missing one X chromosome compared to a normal female but with an additional structurally abnormal chromosome, i(X)).
Figure 3

Karyotype: 46,X,i(X)(q10); the chromosome number: 46; the sex chromosome: X (missing one X chromosome compared to a normal female but with an additional structurally abnormal chromosome, i(X)).

Furthermore, the patient exhibited underdeveloped secondary sexual characteristics, menarche at 18 years with irregular menstruation, and a small uterus, prompting consideration of congenital adrenal hyperplasia (CAH), specifically 17α-hydroxylase deficiency, a chromosomal disorder. However, CAH typically presented with excessive androgens causing masculinization in females, including hirsutism, acne, irregular menstruation, and may involve underdeveloped or absent gonads, low cortisol levels, and elevated adrenocorticotropic hormone (ACTH) levels. This diagnosis was ruled out due to the patient’s normal cortisol and ACTH levels, as well as negative genetic testing for CAH (21-hydroxylase deficiency). Subsequent examinations revealed characteristic features such as short stature, multiple moles, elbow deformity, wide-set eyes, ptosis, and underdeveloped secondary sexual characteristics. Gynecological ultrasound showed a small uterus and premature ovarian failure, suggesting TS. Hormonal analysis showed decreased estradiol levels (14 pg/mL) and elevated FSH levels (82.59 mIU/mL), consistent with the presentation of TS. The diagnosis was confirmed through chromosomal testing, revealing a karyotype of 46X,i(X)(q10).

TS, also known as congenital ovarian dysplasia syndrome, is a chromosomal disorder characterized by distinctive features. Individuals with TS typically exhibit either complete or partial loss of one X chromosome. In the presented case, there was a mosaic/structural abnormality type with the loss of one X chromosome compared to the typical female karyotype, alongside an additional structurally abnormal i(X)(q10) chromosome. Despite clinical similarities to the 45,X0 karyotype (complete loss of one X chromosome), the patient’s symptoms did not align with typical presentations of this karyotype. Research indicates that individuals with TS, especially those with a 45,X0 karyotype, have a high incidence of congenital heart structural abnormalities, affecting up to 50% of cases [4,6]. However, no anomalies were observed in the patient’s echocardiogram or chest-abdomen CTA. Cardiac abnormalities associated with the 45,X0 karyotype often involve the left side of the heart, including issues with the mitral valve, aortic valve, aortic arch anomalies, progressive dilation of the ascending aorta, and aortic coarctation [5,7,8]. The patient experienced menarche at 18 years old, displaying irregular menstruation and exhibiting a small uterus. These clinical features strongly indicate the occurrence of premature ovarian failure, a condition that is highly prevalent in individuals with TS. In a study involving 522 TS patients aged over 12 years, only 14% of those with a 45,X0 karyotype experienced spontaneous thelarche, with higher rates observed in patients with mosaic karyotypes [9].

Extensive research has consistently shown that approximately 30–40% of individuals with TS exhibit congenital abnormalities in the urinary tract. Among them horseshoe kidneys and duplicated renal pelvis with duplicated ureters are the most commonly observed anomalies [10,11]. However, the patient under discussion did not present any congenital structural abnormalities in the urinary tract. Regarding hormonal findings, the patient showed elevated renin and aldosterone levels, consistent with studies reporting that about half of TS patients exhibit significantly increased renin activity, potentially linked to heightened sympathetic nervous system activity [12,13]. Additionally, the patient displayed a non-dipper pattern in blood pressure rhythm, suggesting a possible association with nocturnal sympathetic nervous system dysfunction and alterations in sympathetic-vagal nerve tone [14].

The pathogenesis of hypertension in TS remains unclear [15], and is likely to be multifactorial, involving shared mechanisms with primary hypertension such as autonomic nervous system imbalance, vascular sclerosis, increased myocardial stiffness, estrogen deficiency, renal abnormalities, obesity, and reduced physical endurance [3]. Current treatment strategies for TS patients rely on clinical experience. Initial antihypertensive recommendations often involve drugs that inhibit sympathetic nervous system activity and reduce the risk of aortic dissection, such as beta-blockers and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers [3]. Given the pathophysiological similarities to essential hypertension, calcium channel blockers and diuretics may also be considered for hypertension management in TS [16]. Studies have suggested that estrogen replacement therapy can modulate the renin–angiotensin–aldosterone system and potentially lower blood pressure in patients with ovarian insufficiency [17]. However, there is conflicting evidence regarding the effects of estrogen replacement therapy in women with TS. Some clinical studies indicate that estrogen replacement therapy may worsen endothelial function, leading to arterial stiffness and an increase in central arterial blood pressure [18]. Therefore, the benefits of estrogen replacement therapy in TS patients remain debated.

4 Conclusion

The findings from this case study offered valuable insights capable of guiding the diagnosis and treatment of similar patients in future clinical practice. In the context of young female patients presenting with hypertension, it is crucial to conduct a comprehensive evaluation for potential secondary causes. Particularly, if an individual exhibits clinical manifestations such as underdeveloped secondary sexual characteristics, irregular menstruation, short stature, multiple moles, cubitus valgus, wide-set eyes, and ptosis, TS should be considered. Timely genetic testing is essential to facilitate early identification and intervention, which can ultimately improve long-term prognostic outcomes for patients with TS.

# These authors contributed equally to this study.

Acknowledgements

The authors would like to thank the patient for her willingness to give her consent and approval for publication of this report.

  1. Funding information: This work was funded by the University Scientific Research Program of Anhui Province, China (grant no. 2022AH051238) and Wannan Medical College Youth Fund (WK2023ZQNZ23).

  2. Author contributions: S.H., J.L., and H.T. contributed to this project development, and manuscript editing; S.H., H.T., and X.X. contributed to data collection and manuscript-associated editing; S.H., J.L., and Y.W. contributed to data analysis. All authors contributed to the article and approved the submitted version.

  3. Conflict of interest: Authors state no conflict of interest.

  4. Data availability statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

[1] Classic pages in obstetrics and gynecology by Henry H. Turner. A syndrome of infantilism, congenital webbed neck, and cubitus valgus. Endocrinology. 1938;23:566–74. Am J Obstet Gynecol. 1972;113(2):279.10.1210/endo-23-5-566Search in Google Scholar

[2] Ranke MB, Saenger P. Turner’s syndrome. Lancet. 2001;358(9278):309–14.10.1016/S0140-6736(01)05487-3Search in Google Scholar PubMed

[3] Jones L, Blair J, Hawcutt DB, Lip GYH, Shantsila A. Hypertension in Turner syndrome: a review of proposed mechanisms, management and new directions. J Hypertens. 2023;41(2):203–11. 10.1097/HJH.0000000000003321.Search in Google Scholar PubMed

[4] Silberbach M, Roos-Hesselink JW, Andersen NH, Braverman AC, Brown N, Young LT, et al. American Heart Association Council on Cardiovascular Disease in the Young; Council on Genomic and Precision Medicine; and Council on Peripheral Vascular Disease. Cardiovascular health in Turner syndrome: A scientific statement from the American Heart Association. Circ Genom Precis Med. 2018 Oct;11(10):e000048. 10.1161/HCG.0000000000000048. PMID: 30354301.Search in Google Scholar PubMed

[5] Gravholt CH, Andersen NH, Conway GS, Dekkers OM, Geffner ME, Klein KO, et al. Clinical practice guidelines for the care of girls and women with Turner syndrome: Proceedings from the 2016 Cincinnati International Turner Syndrome Meeting. Eur J Endocrinol. 2017;177:G1–70.10.1530/EJE-17-0430Search in Google Scholar PubMed

[6] Schoemaker MJ, Swerdlow AJ, Higgins CD, Wright AF, Jacobs PA. United Kingdom Clinical Cytogenetics Group. Mortality in women with Turner syndrome in Great Britain: a national cohort study. J Clin Endocrinol Metab. 2008;93:4735–42. 10.1210/jc.2008-1049.Search in Google Scholar PubMed

[7] Gøtzsche CO, Krag-Olsen B, Nielsen J, Sørensen KE, Kristensen BO. Prevalence of cardiovascular malformations and association with karyotypes in Turner’s syndrome. Arch Dis Child. 1994;71:433–6.10.1136/adc.71.5.433Search in Google Scholar PubMed PubMed Central

[8] Völkl TM, Degenhardt K, Koch A, Simm D, Dörr HG, Singer H. Cardiovascular anomalies in children and young adults with Ullrich-Turner syndrome the Erlangen experience. Clin Cardiol. 2005;28:88–92.10.1002/clc.4960280209Search in Google Scholar PubMed PubMed Central

[9] Pasquino AM, Passeri F, Pucarelli I, Segni M, Municchi G. Spontaneous pubertal development in Turner’s syndrome. Italian Study Group for Turner’s syndrome. J Clin Endocrinol Metab. 1997;82:1810–3.10.1210/jcem.82.6.3970Search in Google Scholar PubMed

[10] Bilge I, Kayserili H, Emre S, Nayir A, Sirin A, Tukel T, et al. Frequency of renal malformations in Turner syndrome: analysis of 82 Turkish children. Pediatr Nephrol. 2000;14:1111–4.10.1007/s004670000315Search in Google Scholar PubMed

[11] Lippe B, Geffner ME, Dietrich RB, Boechat MI, Kangarloo H. Renal malformations in patients with Turner syndrome: imaging in 141 patients. Pediatrics. 1988;82:852–6.10.1542/peds.82.6.852Search in Google Scholar

[12] Nathwani NC, Unwin R, Brook CG, Hindmarsh PC. The influence of renal and cardiovascular abnormalities on blood pressure in Turner syndrome. Clin Endocrinol. 2000;52(3):371–7. 10.1046/j.1365-2265.2000.00961.x.Search in Google Scholar PubMed

[13] Saxena PR. Interaction between the renin-angiotensin-aldosterone and sympathetic nervous systems. J Cardiovasc Pharmacol. 1992;19:S80. 10.1097/00005344-199219006-00013.Search in Google Scholar PubMed

[14] McCarrison S, Carr A, Wong SC, Mason A. The prevalence of hypertension in paediatric Turner syndrome: a systematic review and meta-analysis. J Hum Hypertens. 2022. 10.1038/s41371-022-00777-8.Search in Google Scholar PubMed PubMed Central

[15] De Groote K, Demulier L, De Backer J, De Wolf D, De Schepper J, T’sjoen G, et al. Arterial hypertension in Turner syndrome: a review of the literature and a practical approach for diagnosis and treatment. J Hypertens. 2015;33:1342–51.10.1097/HJH.0000000000000599Search in Google Scholar PubMed

[16] Bondy CA. Aortic dissection in Turner syndrome. Curr Opin Cardiol. 2008;23:519–26.10.1097/HCO.0b013e3283129b89Search in Google Scholar

[17] Gersh FL, O’Keefe JH, Lavie CJ, Henry BM. The renin-angiotensin-aldosterone system in postmenopausal women: the promise of hormone therapy. Mayo Clin Proc. 2021;96(12):3130–41.10.1016/j.mayocp.2021.08.009Search in Google Scholar PubMed

[18] Peppa M, Pavlidis G, Mavroeidi I, Katogiannis K, Varoudi M, Ikonomidis I, et al. Effects of hormone replacement therapy on endothelial function, arterial stiffness and myocardial deformation in women with Turner syndrome. J Hypertens. 2021;39(10):2051–7.10.1097/HJH.0000000000002903Search in Google Scholar PubMed

Received: 2024-02-26
Revised: 2024-07-01
Accepted: 2024-07-09
Published Online: 2024-08-06

© 2024 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  135. Axodendritic targeting of TAU and MAP2 and microtubule polarization in iPSC-derived versus SH-SY5Y-derived human neurons
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  138. BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis
  139. Role of circRMRP and circRPL27 in chronic obstructive pulmonary disease
  140. Investigating the role of hyperexpressed HCN1 in inducing myocardial infarction through activation of the NF-κB signaling pathway
  141. Characterization of phenolic compounds and evaluation of anti-diabetic potential in Cannabis sativa L. seeds: In vivo, in vitro, and in silico studies
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  143. Ecology and Environmental Science
  144. Screening of different growth conditions of Bacillus subtilis isolated from membrane-less microbial fuel cell toward antimicrobial activity profiling
  145. Degradation of a mixture of 13 polycyclic aromatic hydrocarbons by commercial effective microorganisms
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  147. Prediction of present and future distribution areas of Juniperus drupacea Labill and determination of ethnobotany properties in Antalya Province, Türkiye
  148. Population genetics of Todarodes pacificus (Cephalopoda: Ommastrephidae) in the northwest Pacific Ocean via GBS sequencing
  149. A comparative analysis of dendrometric, macromorphological, and micromorphological characteristics of Pistacia atlantica subsp. atlantica and Pistacia terebinthus in the middle Atlas region of Morocco
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  175. Plant Sciences
  176. Effect of long-term in-row branch covering on soil microorganisms in pear orchards
  177. Photosynthetic physiological characteristics, growth performance, and element concentrations reveal the calcicole–calcifuge behaviors of three Camellia species
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  179. Bioinformatics, expression analysis, and functional verification of allene oxide synthase gene HvnAOS1 and HvnAOS2 in qingke
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  182. Role of Embinin in the reabsorption of nucleus pulposus in lumbar disc herniation: Promotion of nucleus pulposus neovascularization and apoptosis of nucleus pulposus cells
  183. Revealing the effects of amino acid, organic acid, and phytohormones on the germination of tomato seeds under salinity stress
  184. Combined effects of nitrogen fertilizer and biochar on the growth, yield, and quality of pepper
  185. Comprehensive phytochemical and toxicological analysis of Chenopodium ambrosioides (L.) fractions
  186. Impact of “3414” fertilization on the yield and quality of greenhouse tomatoes
  187. Exploring the coupling mode of water and fertilizer for improving growth, fruit quality, and yield of the pear in the arid region
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  189. Antibacterial, antifungal, and phytochemical properties of Salsola kali ethanolic extract
  190. Exploring the hepatoprotective properties of citronellol: In vitro and in silico studies on ethanol-induced damage in HepG2 cells
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  192. Effects of exogenous 2,4-epibrassinolide on photosynthetic traits of 53 cowpea varieties under NaCl stress
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  196. Antioxidant and antimicrobial activities of Salsola imbricata methanolic extract and its phytochemical characterization
  197. Bioengineering and Biotechnology
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  199. New advances in protein engineering for industrial applications: Key takeaways
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  201. Research progress of nanoparticles in diagnosis and treatment of hepatocellular carcinoma
  202. Bioelectrochemical biosensors for water quality assessment and wastewater monitoring
  203. PEI/MMNs@LNA-542 nanoparticles alleviate ICU-acquired weakness through targeted autophagy inhibition and mitochondrial protection
  204. Unleashing of cytotoxic effects of thymoquinone-bovine serum albumin nanoparticles on A549 lung cancer cells
  205. Erratum
  206. Erratum to “Investigating the association between dietary patterns and glycemic control among children and adolescents with T1DM”
  207. Erratum to “Activation of hypermethylated P2RY1 mitigates gastric cancer by promoting apoptosis and inhibiting proliferation”
  208. Retraction
  209. Retraction to “MiR-223-3p regulates cell viability, migration, invasion, and apoptosis of non-small cell lung cancer cells by targeting RHOB”
  210. Retraction to “A data mining technique for detecting malignant mesothelioma cancer using multiple regression analysis”
  211. Special Issue on Advances in Neurodegenerative Disease Research and Treatment
  212. Transplantation of human neural stem cell prevents symptomatic motor behavior disability in a rat model of Parkinson’s disease
  213. Special Issue on Multi-omics
  214. Inflammasome complex genes with clinical relevance suggest potential as therapeutic targets for anti-tumor drugs in clear cell renal cell carcinoma
  215. Gastroesophageal varices in primary biliary cholangitis with anti-centromere antibody positivity: Early onset?
https://doi.org/10.1515/biol-2022-0934
Keywords for this article
hypertension; Turner syndrome; sex chromosome disorder
Creative Commons
BY 4.0

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  158. Knockdown of USP7 alleviates atherosclerosis in ApoE-deficient mice by regulating EZH2 expression
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  163. Perspectives of pteridophytes microbiome for bioremediation in agricultural applications
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  165. Improving the productivity and profitability of maize (Zea mays L.) using optimum blended inorganic fertilization
  166. Application of leaf multispectral analyzer in comparison to hyperspectral device to assess the diversity of spectral reflectance indices in wheat genotypes
  167. Animal Sciences
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  169. Development of a detection chip for major pathogenic drug-resistant genes and drug targets in bovine respiratory system diseases
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  177. Photosynthetic physiological characteristics, growth performance, and element concentrations reveal the calcicole–calcifuge behaviors of three Camellia species
  178. Transcriptome analysis reveals the mechanism of NaHCO3 promoting tobacco leaf maturation
  179. Bioinformatics, expression analysis, and functional verification of allene oxide synthase gene HvnAOS1 and HvnAOS2 in qingke
  180. Water, nitrogen, and phosphorus coupling improves gray jujube fruit quality and yield
  181. Improving grape fruit quality through soil conditioner: Insights from RNA-seq analysis of Cabernet Sauvignon roots
  182. Role of Embinin in the reabsorption of nucleus pulposus in lumbar disc herniation: Promotion of nucleus pulposus neovascularization and apoptosis of nucleus pulposus cells
  183. Revealing the effects of amino acid, organic acid, and phytohormones on the germination of tomato seeds under salinity stress
  184. Combined effects of nitrogen fertilizer and biochar on the growth, yield, and quality of pepper
  185. Comprehensive phytochemical and toxicological analysis of Chenopodium ambrosioides (L.) fractions
  186. Impact of “3414” fertilization on the yield and quality of greenhouse tomatoes
  187. Exploring the coupling mode of water and fertilizer for improving growth, fruit quality, and yield of the pear in the arid region
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  189. Antibacterial, antifungal, and phytochemical properties of Salsola kali ethanolic extract
  190. Exploring the hepatoprotective properties of citronellol: In vitro and in silico studies on ethanol-induced damage in HepG2 cells
  191. Enhanced osmotic dehydration of watermelon rind using honey–sucrose solutions: A study on pre-treatment efficacy and mass transfer kinetics
  192. Effects of exogenous 2,4-epibrassinolide on photosynthetic traits of 53 cowpea varieties under NaCl stress
  193. Comparative transcriptome analysis of maize (Zea mays L.) seedlings in response to copper stress
  194. An optimization method for measuring the stomata in cassava (Manihot esculenta Crantz) under multiple abiotic stresses
  195. Fosinopril inhibits Ang II-induced VSMC proliferation, phenotype transformation, migration, and oxidative stress through the TGF-β1/Smad signaling pathway
  196. Antioxidant and antimicrobial activities of Salsola imbricata methanolic extract and its phytochemical characterization
  197. Bioengineering and Biotechnology
  198. Absorbable calcium and phosphorus bioactive membranes promote bone marrow mesenchymal stem cells osteogenic differentiation for bone regeneration
  199. New advances in protein engineering for industrial applications: Key takeaways
  200. An overview of the production and use of Bacillus thuringiensis toxin
  201. Research progress of nanoparticles in diagnosis and treatment of hepatocellular carcinoma
  202. Bioelectrochemical biosensors for water quality assessment and wastewater monitoring
  203. PEI/MMNs@LNA-542 nanoparticles alleviate ICU-acquired weakness through targeted autophagy inhibition and mitochondrial protection
  204. Unleashing of cytotoxic effects of thymoquinone-bovine serum albumin nanoparticles on A549 lung cancer cells
  205. Erratum
  206. Erratum to “Investigating the association between dietary patterns and glycemic control among children and adolescents with T1DM”
  207. Erratum to “Activation of hypermethylated P2RY1 mitigates gastric cancer by promoting apoptosis and inhibiting proliferation”
  208. Retraction
  209. Retraction to “MiR-223-3p regulates cell viability, migration, invasion, and apoptosis of non-small cell lung cancer cells by targeting RHOB”
  210. Retraction to “A data mining technique for detecting malignant mesothelioma cancer using multiple regression analysis”
  211. Special Issue on Advances in Neurodegenerative Disease Research and Treatment
  212. Transplantation of human neural stem cell prevents symptomatic motor behavior disability in a rat model of Parkinson’s disease
  213. Special Issue on Multi-omics
  214. Inflammasome complex genes with clinical relevance suggest potential as therapeutic targets for anti-tumor drugs in clear cell renal cell carcinoma
  215. Gastroesophageal varices in primary biliary cholangitis with anti-centromere antibody positivity: Early onset?
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