Home The role of expert evaluation for microsleep detection
Article Open Access

The role of expert evaluation for microsleep detection

  • M. Golz EMAIL logo , A. Schenka , D. Sommer , B. Geißler and A. Muttray
Published/Copyright: September 12, 2015

Abstract

Recently, it has been shown by overnight driving simulation studies that microsleep density is the only known sleepiness indicator which rapidly increases within a few seconds immediately before sleepiness related crashes. This indicator is based solely on EEG and EOG and subsequent adaptive pattern recognition. Accurate microsleep recognition is very important for the performance of this sleepiness indicator. The question is whether expensive evaluations of microsleep events by a) experts are necessary or b) non-experts provide sufficient evaluations. Based on 11,114 microsleep events in case a) and 12,787 in case b) recognition accuracies were investigated utilizing (i) artificial neural networks and (ii) support-vector machines. Cross validated classification accuracies ranged between 92.2 % for (i,b) and 99.3 % for (ii, a). It is concluded that expert evaluations are very important to provide independent information for detecting microsleep.

1 Introduction

The assessment of driver sleepiness is still a challenging task from the technological as well as scientific point of view. It is very important in the light of risk management, since drowsy driving represents 10 to 30 percent of all crashes [1]. It was estimated that 160,000 injuries and 6,000 deaths each year in the European Union are primarily caused by sleepiness (cf. [1] and references therein).

Using our driving simulator, it has been demonstrated that immediately before crashes several sleepiness indicators do not change, with the exception of EEG / EOG microsleep density [2]. Only microsleep density zooms up within a few seconds. This indicator is defined as the percentage of microsleep patterns found in EEG and EOG within an accumulation interval of 2 min in length. Machine learning algorithms are used for the detection of microsleep events (MSE). During supervised learning, these algorithms require EEG / EOG as input data and information on the desired output as well. The latter is a binary variable and consists of either MSE or counterexamples (Non-MSE). MSE can be obtained by the following determination methodologies. Non-MSE are periods in time where drivers are drowsy but still able to drive.

The determination of MSE includes some trade-offs. One way is to define them only by EEG criteria [3]. It is assumed that spectral deceleration of the EEG is typical for MSE. Commonly, an EEG expert searches for theta activity which has replaced waking alpha background. However, there are a number of decelerations without concomitant impairment in driving ability [4]. Furthermore, several authors observed that alpha not theta activity plays a prominent role in driver sleepiness (e.g. [5]).

A second type of MSE determination is based on behaviour and assumes that lapses in motor response within continuous steering tasks are typical for MSE [6]. The problem here is that other causes like e.g. cognitive distraction or lack of concentration not related to sleepiness may be present. Advantageously, all dangerous performance lapses are included in analyses, independent of their inner causes. Recently, the same group [6] presented a determination combined with the third type [7].

In the third type of MSE determination a trained person performs subjective video ratings of driver’s behaviour, especially based on eye and head movements. If prolonged eye lid closures, rolling eye movements, slow head movements, head nods, or similar typical signs of MSE exhibit an event is annotated manually. It must be emphasized that a precise definition of MSE cannot be made due to the inter-individual differences in behaviour; it remains a subjective decision.

Advantageously, during evaluation the observer traces the temporal development of driver’s behaviour and is prepared to expect occurrence of MSE.

In the following, the last kind of MSE determination is regarded. For this purpose, highly motivated and trained observers are requested. It is asked whether longstanding experts with deep knowledge and wide experiences are essential or not. On the other side, undergraduate and graduate students trained for several days were motivated to perform video rating.

2 Material and methods

2.1 Driving simulation studies

Detailed information on this topic has been published earlier [5]. In short, 16 young adults (mean age 24.4 ±3.1 years) were randomly selected out of 133 interested volunteers. Two experimental nights per subject were conducted. During three days before experiments it was checked by actimetry whether the scheduled sleep wake restrictions were fulfilled (wake up time: 6:00-8:00, time to bed: 22:00-1:00). Furthermore, it was checked whether during the day before experiments no short sleep (naps) happened. This way, a relatively large time since sleep was ensured which is an important factor of sleepiness. Experiments started at 22:30 and ended at 7:30 and included 8 driving sessions of 40 min duration each. EEG (Fp1, Fp2, A1, C3, Cz, C4, A2, O1, O2; common average reference) and EOG (vertical, horizontal) were recorded (device: Sigma PLpro, Sigma Medizintechnik GmbH, Gelenau, Germany).

Behavioural MSE were evaluated by a) one expert with longstanding knowledge and experiences in the field, and by b) 9 non-experts with some knowledge and experiences lasting not longer than 9 months. Based on visual evaluations of video material, of lane deviation time series and of EOG, their task was to search for critical events and to assign each event to one of 6 severity levels (1 = vague or very short signs of MSE lasting not longer than 0.3 sec.; 2 = short MSE lasting between 0.3 and 1.5 sec., 3 – 6 = extended MSE with duration of at least 2.5, 3.5, 4.5, and 5.5 sec., respectively). Lane deviation is an output variable of the driving simulator and is the lateral position of the car with respect to the centre of the lane.

In addition, the starting time of each MSE was determined as accurately as possible. For supervised learning methods counterexamples (Non-MSE) are needed, i.e. periods in time where the driver is drowsy but still able to keep the car in lane. If both classes of data (MSE, Non-MSE) have the same amount (balanced data set) then a discriminant function can be learned which has no bias error due to unequal a-priori class probabilities. Therefore, the expert as well as the non-experts were requested to search for Non-MSE.

2.2 Pattern recognition

Data analysis was based on clearly visible MSE (level 2 – 6). Pre-processing included signal segmentation for each MSE and for the same amount of Non-MSE. As mentioned above, Non-MSE are periods in time where subjects were drowsy, but were able to keep the car in lane. Logarithmic power spectral densities averaged in narrow bands

(0.5 <f <23.5 Hz, Δf = 2 Hz) were estimated using modified periodogram. Alternatively, Welch’s and multi-taper method were applied, but resulted in slightly lower classification accuracies. Delay-vector variances were further features extracted from all signals [9]. After that, feature vectors were processed by LVQ (learning vector quantization) and SVM (support-vector machines) in order to assign them to class labels (MSE or Non-MSE). This classification step included machine learning, where internal parameters of LVQ and SVM are optimized. After finishing learning, cross validation analysis was performed; outputs were mean and standard deviation of classification accuracies for training as well as validation data. Both data sets were constituted by multiple, random subsampling. Parameters of all processing steps were optimized such that training set accuracies were maximal (see Figure 1). Validation set accuracy is the main outcome; it is an empirical estimate of the true classification performance.

Figure 1 Pattern recognition consisted of four different stages. Parameters of the first three stages were optimized in order to gain maximal accuracy (ACC) on input data (training set). Input data were signal features of EEG / EOG as well as class labels, i.e. microsleep events (MSE) and non-microsleep (Non-MSE), for further explanations see text.
Figure 1

Pattern recognition consisted of four different stages. Parameters of the first three stages were optimized in order to gain maximal accuracy (ACC) on input data (training set). Input data were signal features of EEG / EOG as well as class labels, i.e. microsleep events (MSE) and non-microsleep (Non-MSE), for further explanations see text.

Table 1

Number of MSE for different severity levels (see text) depending on visual evaluation by a) expert and b) non-expert.

Severity level1.2.3.4.5.6.
a) Expert evaluation13,0956,1822,8061,231573322
b) Non-expert eval.4,8305,8463,8611,596880604

3 Results

Recordings of 32 overnight experiments (16 subjects, 2 nights each) were evaluated. Each night consisted of 8 driving sessions of 40 min duration each, resulting in 10,240 min total driving time. Each of 9 different non-experts evaluated driver behaviour for some driving sessions. There was no fixed allocation; non-experts evaluated between 10 and 30 driving sessions. In contrast, the expert evaluated all 256 driving sessions (32 nights, 8 sessions each). A lot of differences occurred between both evaluations (Table 1). The sum of all events including vague events (level 1) was a) 24,209 and b) 17,617. Clearly visible MSE (level 2 – 6) added up to a) 11,114 and b) 12,787.

Expert and non-expert evaluations resulted in different annotations for the following three reasons:

1. Different severity levels of MSE,

2. Different adjustment of the starting times of MSE,

3. Different adjustment of the starting times of Non-MSE.

In consequence, two different sets of MSE and Non-MSE were used in further signal processing and subsequent classification. As a result of many parameter optimizations, mean and standard deviation of classification accuracy were computed. Due to the paradigm of cross validation, classification accuracies were estimated on training data (Table 2) as well as on test data (Table 3). The first is an inspection of the adaptivity of the classifier and indicates numerical problems if existing. The second is an inspection of the ability of the pattern recognition methodology to generalize and is an estimation of the true classification accuracy. It gives an impression in which range accuracies for future examples should lie provided that a representative sample is given.

Table 2

Classification accuracies (mean and standard deviation) for training data set based on a) expert and b) non-expert evaluations and two classifiers, namely (i) learning vector quantization (LVQ) and (ii) support-vector machines (SVM).

ClassifierLVQSVM
a) Expert evaluation99.45 ±0.17 %99.92 ±0.00 %
b) Non-expert evaluation94.81 ±0.35 %99.09 ±0.00 %
Table 3

Classification accuracies (mean and standard deviation) for test data set based on a) expert and b) non-expert evaluations and two classifiers, namely (i) learning vector quantization (LVQ) and (ii) support-vector machines (SVM).

ClassifierLVQSVM
a) Expert evaluation98.22±0.55 %99.34 ±0.04 %
b) Non-expert evaluation92.20 ±0.65 %95.84 ±0.08 %

4 Conclusion

Results offer remarkable differences between a) expert and b) non-expert evaluation. Non-experts tended to overestimate severity level of MSE and evaluated much more events on levels 3 – 6 than the expert. On the other hand, a lot of vague events were not noticed by non-experts. Vague events were not included within analysis presented, but will be subject of future investigations. Another key difference between a) and b) lies in determining MSE starting time. Several larger errors of the non-experts were found by the expert. They were not comprehensible and are presumably due to limited endurance and low motivation. Visual evaluations are common in clinical practise and in life science research. They are known to be tedious and demo-tivating.

The expert himself reported that he has continuously extended his intrinsic criteria for his decisions, because behaviour during extreme fatigue was relatively complex and differed largely between subjects. Therefore, it is likely that he would classify some events different if he would again evaluate the recordings. It is an open question how large the resulting alterations would be and if machine learning algorithm would even better work or not.

Support-vector machines outperformed learning vector quantization. This result shows that strict mathematical concepts, like large margin optimization and nonlinear mapping to higher-dimensional spaces via kernel functions, are superior to stochastic optimization concepts with less mathematical rigidity. The machine learning process of support-vector machines has much more computational load as of learning vector quantisation; the difference was in the region of up to 106. For very large data sets this might pose a problem.

Further relevant improvements in classification accuracies are hardly to obtain, especially for support-vector machines, because 99.3 % is already a very high value. But it must be emphasized that data of all drivers were part of training as well as validation data. The learning classifiers were adapted to data of all drivers and it was possible to generalize (Table 3), i.e. accuracies of unlearned data were almost as large as of learned data. Further investigations should include subject hold-out validation, which means that training data consists of MSE of all but one subject. Validation data consist only of data of the one subject which is hold-out from the training set. If this procedure was repeated for every subject, mean and standard deviation would give estimation on how accurate MSE can be recognized for drivers which may be included in future investigations with the same methodology.

In summary, it can be stated that non-expert evaluation of MSE is sufficient for high recognition success, but only expert evaluation paves the way for highly accurate MSE detection. This way, a laboratory reference standard of driver sleepiness has been established which can be used to evaluate devices for fatigue monitoring [8].

Another important application for applied research and maybe for future warning systems might be an on-line closed-loop MSE detection and mitigation system based on dry electrode EEG [10]. If MSE were detected then immediate auditory warnings were presented to the driver. It has been demonstrated that the effectiveness of arousing auditory warnings might depend on EEG spectra features [10].

Effective warnings led to improved driver’s response times to subsequent lane departure events. Furthermore, it has been demonstrated that for upcoming MSE the EEG power spectral densities immediately changed and that through warnings they came back to signatures which are typical for the alert state without bouncing back to the drowsy level. In future, this might lead to real-life applications of the dry and wireless EEG technology based on smart-phones as mobile signal processing platform.

Funding: This study was funded by the Federal Ministry of Education and Research within the research program “Research at University of Applied Sciences together with Enterprises” under the project 176X08.

Author’s Statement

  1. Conflict of interest: Authors state no conflict of interest.

    Material and Methods: Informed consent: Informed consent has been obtained from all individuals included in this study. Ethical approval: The research related to human use has been complied with all the relevant national regulations, institutional policies and in accordance the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.

References

[1] Garbarino S, Gelsomino G, Magnavita N. Sleepiness, safety and transport. J Ergonomics (2014) S3:003. 10.4172/2165-7556.S3-003.Search in Google Scholar

[2] Golz M, Sommer D, Geißler B, Muttray A. Comparison of EEG-based measures of driver sleepiness. Biomed Tech (2014) 59: S197-S200Search in Google Scholar

[3] Boyle L, Tippin J, Paul A, Rizzo M. Driver performance in the moments surrounding a microsleep. Transp Res (2008) F 11: 126-13610.1016/j.trf.2007.08.001Search in Google Scholar

[4] Golz M, Sommer D, Krajewski J. Driver sleepiness assessed by electroencephalography - different methods applied to one single data set. Proc 8th Int Conf Driving Assessment (2015), to appear.10.17077/drivingassessment.1595Search in Google Scholar

[5] Torsvall L, 〈kerstedt T. Sleepiness on the job: continuously measured EEG changes in train drivers. Electroencephal Clin Neurophysiol (1987) 66:502-511.10.1016/0013-4694(87)90096-4Search in Google Scholar

[6] Peiris M, Jones R, Davidson P, Bones P. Detecting behaviorral microsleeps from EEG power spectra. Proc 28th EMBS Conf (2006), 5723-5726.10.1109/IEMBS.2006.260411Search in Google Scholar PubMed

[7] Poudel G, Innes C, Bones P, Watts R, Jones R. Losing the struggle to stay awake: divergent thalamic and cortical activity during microsleeps. Human Brain Mapping (2014), 35:257-269.10.1002/hbm.22178Search in Google Scholar PubMed PubMed Central

[8] Golz M, Sommer D, Trutschel U, Sirois B, Edwards D. Evaluation of fatigue monitoring technologies. Somnologie (2010), 14(3):187-199.10.1007/s11818-010-0482-9Search in Google Scholar

[9] Golz M, Sommer D, Chen M, Trutschel U, Mandic D. Feature fusion for the detection of microsleep events. VLSI Signal Process (2007), 49: 329-342.10.1007/s11265-007-0083-4Search in Google Scholar

[10] Wang Y-T, Huang K-C, Wei C-S, Huang T-Y, Ko L-W, Lin C-T, Cheng C-K, Jung T-P. Developing an EEG-based on-line closed-loop lapse detection and mitigation system. Front. Neurosci. (2014) 8:321. 10.3389/fnins.2014.00321.Search in Google Scholar PubMed PubMed Central

Published Online: 2015-9-12
Published in Print: 2015-9-1

© 2015 by Walter de Gruyter GmbH, Berlin/Boston

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Articles in the same Issue

  1. Research Article
  2. Development and characterization of superparamagnetic coatings
  3. Research Article
  4. The development of an experimental setup to measure acousto-electric interaction signal
  5. Research Article
  6. Stability analysis of ferrofluids
  7. Research Article
  8. Investigation of endothelial growth using a sensors-integrated microfluidic system to simulate physiological barriers
  9. Research Article
  10. Energy harvesting for active implants: powering a ruminal pH-monitoring system
  11. Research Article
  12. New type of fluxgate magnetometer for the heart’s magnetic fields detection
  13. Research Article
  14. Field mapping of ballistic pressure pulse sources
  15. Research Article
  16. Development of a new homecare sleep monitor using body sounds and motion tracking
  17. Research Article
  18. Noise properties of textile, capacitive EEG electrodes
  19. Research Article
  20. Detecting phase singularities and rotor center trajectories based on the Hilbert transform of intraatrial electrograms in an atrial voxel model
  21. Research Article
  22. Spike sorting: the overlapping spikes challenge
  23. Research Article
  24. Separating the effect of respiration from the heart rate variability for cases of constant harmonic breathing
  25. Research Article
  26. Locating regions of arrhythmogenic substrate by analyzing the duration of triggered atrial activities
  27. Research Article
  28. Combining different ECG derived respiration tracking methods to create an optimal reconstruction of the breathing pattern
  29. Research Article
  30. Atrial and ventricular signal averaging electrocardiography in pacemaker and cardiac resynchronization therapy
  31. Research Article
  32. Estimation of a respiratory signal from a single-lead ECG using the 4th order central moments
  33. Research Article
  34. Compressed sensing of multi-lead ECG signals by compressive multiplexing
  35. Research Article
  36. Heart rate monitoring in ultra-high-field MRI using frequency information obtained from video signals of the human skin compared to electrocardiography and pulse oximetry
  37. Research Article
  38. Synchronization in wireless biomedical-sensor networks with Bluetooth Low Energy
  39. Research Article
  40. Automated classification of stages of anaesthesia by populations of evolutionary optimized fuzzy rules
  41. Research Article
  42. Effects of sampling rate on automated fatigue recognition in surface EMG signals
  43. Research Article
  44. Closed-loop transcranial alternating current stimulation of slow oscillations
  45. Research Article
  46. Cardiac index in atrio- and interventricular delay optimized cardiac resynchronization therapy and cardiac contractility modulation
  47. Research Article
  48. The role of expert evaluation for microsleep detection
  49. Research Article
  50. The impact of baseline wander removal techniques on the ST segment in simulated ischemic 12-lead ECGs
  51. Research Article
  52. Metal artifact reduction by projection replacements and non-local prior image integration
  53. Research Article
  54. A novel coaxial nozzle for in-process adjustment of electrospun scaffolds’ fiber diameter
  55. Research Article
  56. Processing of membranes for oxygenation using the Bellhouse-effect
  57. Research Article
  58. Inkjet printing of viable human dental follicle stem cells
  59. Research Article
  60. The use of an icebindingprotein out of the snowflea Hypogastrura harveyi as a cryoprotectant in the cryopreservation of mesenchymal stem cells
  61. Research Article
  62. New NIR spectroscopy based method to determine ischemia in vivo in liver – a first study on rats
  63. Research Article
  64. QRS and QT ventricular conduction times and permanent pacemaker therapy after transcatheter aortic valve implantation
  65. Research Article
  66. Adopting oculopressure tonometry as a transient in vivo rabbit glaucoma model
  67. Research Article
  68. Next-generation vision testing: the quick CSF
  69. Research Article
  70. Improving tactile sensation in laparoscopic surgery by overcoming size restrictions
  71. Research Article
  72. Design and control of a 3-DOF hydraulic driven surgical instrument
  73. Research Article
  74. Evaluation of endourological tools to improve the diagnosis and therapy of ureteral tumors – from model development to clinical application
  75. Research Article
  76. Frequency based assessment of surgical activities
  77. Research Article
  78. “Hands free for intervention”, a new approach for transoral endoscopic surgery
  79. Research Article
  80. Pseudo-haptic feedback in medical teleoperation
  81. Research Article
  82. Feasibility of interactive gesture control of a robotic microscope
  83. Research Article
  84. Towards structuring contextual information for workflow-driven surgical assistance functionalities
  85. Research Article
  86. Towards a framework for standardized semantic workflow modeling and management in the surgical domain
  87. Research Article
  88. Closed-loop approach for situation awareness of medical devices and operating room infrastructure
  89. Research Article
  90. Kinect based physiotherapy system for home use
  91. Research Article
  92. Evaluating the microsoft kinect skeleton joint tracking as a tool for home-based physiotherapy
  93. Research Article
  94. Integrating multimodal information for intraoperative assistance in neurosurgery
  95. Research Article
  96. Respiratory motion tracking using Microsoft’s Kinect v2 camera
  97. Research Article
  98. Using smart glasses for ultrasound diagnostics
  99. Research Article
  100. Measurement of needle susceptibility artifacts in magnetic resonance images
  101. Research Article
  102. Dimensionality reduction of medical image descriptors for multimodal image registration
  103. Research Article
  104. Experimental evaluation of different weighting schemes in magnetic particle imaging reconstruction
  105. Research Article
  106. Evaluation of CT capability for the detection of thin bone structures
  107. Research Article
  108. Towards contactless optical coherence elastography with acoustic tissue excitation
  109. Research Article
  110. Development and implementation of algorithms for automatic and robust measurement of the 2D:4D digit ratio using image data
  111. Research Article
  112. Automated high-throughput analysis of B cell spreading on immobilized antibodies with whole slide imaging
  113. Research Article
  114. Tissue segmentation from head MRI: a ground truth validation for feature-enhanced tracking
  115. Research Article
  116. Video tracking of swimming rodents on a reflective water surface
  117. Research Article
  118. MR imaging of model drug distribution in simulated vitreous
  119. Research Article
  120. Studying the extracellular contribution to the double wave vector diffusion-weighted signal
  121. Research Article
  122. Artifacts in field free line magnetic particle imaging in the presence of inhomogeneous and nonlinear magnetic fields
  123. Research Article
  124. Introducing a frequency-tunable magnetic particle spectrometer
  125. Research Article
  126. Imaging of aortic valve dynamics in 4D OCT
  127. Research Article
  128. Intravascular optical coherence tomography (OCT) as an additional tool for the assessment of stent structures
  129. Research Article
  130. Simple concept for a wide-field lensless digital holographic microscope using a laser diode
  131. Research Article
  132. Intraoperative identification of somato-sensory brain areas using optical imaging and standard RGB camera equipment – a feasibility study
  133. Research Article
  134. Respiratory surface motion measurement by Microsoft Kinect
  135. Research Article
  136. Improving image quality in EIT imaging by measurement of thorax excursion
  137. Research Article
  138. A clustering based dual model framework for EIT imaging: first experimental results
  139. Research Article
  140. Three-dimensional anisotropic regularization for limited angle tomography
  141. Research Article
  142. GPU-based real-time generation of large ultrasound volumes from freehand 3D sweeps
  143. Research Article
  144. Experimental computer tomograph
  145. Research Article
  146. US-tracked steered FUS in a respiratory ex vivo ovine liver phantom
  147. Research Article
  148. Contribution of brownian rotation and particle assembly polarisation to the particle response in magnetic particle spectrometry
  149. Research Article
  150. Preliminary investigations of magnetic modulated nanoparticles for microwave breast cancer detection
  151. Research Article
  152. Construction of a device for magnetic separation of superparamagnetic iron oxide nanoparticles
  153. Research Article
  154. An IHE-conform telecooperation platform supporting the treatment of dementia patients
  155. Research Article
  156. Automated respiratory therapy system based on the ARDSNet protocol with systemic perfusion control
  157. Research Article
  158. Identification of surgical instruments using UHF-RFID technology
  159. Research Article
  160. A generic concept for the development of model-guided clinical decision support systems
  161. Research Article
  162. Evaluation of local alterations in femoral bone mineral density measured via quantitative CT
  163. Research Article
  164. Creating 3D gelatin phantoms for experimental evaluation in biomedicine
  165. Research Article
  166. Influence of short-term fixation with mixed formalin or ethanol solution on the mechanical properties of human cortical bone
  167. Research Article
  168. Analysis of the release kinetics of surface-bound proteins via laser-induced fluorescence
  169. Research Article
  170. Tomographic particle image velocimetry of a water-jet for low volume harvesting of fat tissue for regenerative medicine
  171. Research Article
  172. Wireless medical sensors – context, robustness and safety
  173. Research Article
  174. Sequences for real-time magnetic particle imaging
  175. Research Article
  176. Speckle-based off-axis holographic detection for non-contact photoacoustic tomography
  177. Research Article
  178. A machine learning approach for planning valve-sparing aortic root reconstruction
  179. Research Article
  180. An in-ear pulse wave velocity measurement system using heart sounds as time reference
  181. Research Article
  182. Measuring different oxygenation levels in a blood perfusion model simulating the human head using NIRS
  183. Research Article
  184. Multisegmental fusion of the lumbar spine a curse or a blessing?
  185. Research Article
  186. Numerical analysis of the biomechanical complications accompanying the total hip replacement with NANOS-Prosthetic: bone remodelling and prosthesis migration
  187. Research Article
  188. A muscle model for hybrid muscle activation
  189. Research Article
  190. Mathematical, numerical and in-vitro investigation of cooling performance of an intra-carotid catheter for selective brain hypothermia
  191. Research Article
  192. An ideally parameterized unscented Kalman filter for the inverse problem of electrocardiography
  193. Research Article
  194. Interactive visualization of cardiac anatomy and atrial excitation for medical diagnosis and research
  195. Research Article
  196. Virtualizing clinical cases of atrial flutter in a fast marching simulation including conduction velocity and ablation scars
  197. Research Article
  198. Mesh structure-independent modeling of patient-specific atrial fiber orientation
  199. Research Article
  200. Accelerating mono-domain cardiac electrophysiology simulations using OpenCL
  201. Research Article
  202. Understanding the cellular mode of action of vernakalant using a computational model: answers and new questions
  203. Research Article
  204. A java based simulator with user interface to simulate ventilated patients
  205. Research Article
  206. Evaluation of an algorithm to choose between competing models of respiratory mechanics
  207. Research Article
  208. Numerical simulation of low-pulsation gerotor pumps for use in the pharmaceutical industry and in biomedicine
  209. Research Article
  210. Numerical and experimental flow analysis in centifluidic systems for rapid allergy screening tests
  211. Research Article
  212. Biomechanical parameter determination of scaffold-free cartilage constructs (SFCCs) with the hyperelastic material models Yeoh, Ogden and Demiray
  213. Research Article
  214. FPGA controlled artificial vascular system
  215. Research Article
  216. Simulation based investigation of source-detector configurations for non-invasive fetal pulse oximetry
  217. Research Article
  218. Test setup for characterizing the efficacy of embolic protection devices
  219. Research Article
  220. Impact of electrode geometry on force generation during functional electrical stimulation
  221. Research Article
  222. 3D-based visual physical activity assessment of children
  223. Research Article
  224. Realtime assessment of foot orientation by Accelerometers and Gyroscopes
  225. Research Article
  226. Image based reconstruction for cystoscopy
  227. Research Article
  228. Image guided surgery innovation with graduate students - a new lecture format
  229. Research Article
  230. Multichannel FES parameterization for controlling foot motion in paretic gait
  231. Research Article
  232. Smartphone supported upper limb prosthesis
  233. Research Article
  234. Use of quantitative tremor evaluation to enhance target selection during deep brain stimulation surgery for essential tremor
  235. Research Article
  236. Evaluation of adhesion promoters for Parylene C on gold metallization
  237. Research Article
  238. The influence of metallic ions from CoCr28Mo6 on the osteogenic differentiation and cytokine release of human osteoblasts
  239. Research Article
  240. Increasing the visibility of thin NITINOL vascular implants
  241. Research Article
  242. Possible reasons for early artificial bone failure in biomechanical tests of ankle arthrodesis systems
  243. Research Article
  244. Development of a bending test procedure for the characterization of flexible ECoG electrode arrays
  245. Research Article
  246. Tubular manipulators: a new concept for intracochlear positioning of an auditory prosthesis
  247. Research Article
  248. Investigation of the dynamic diameter deformation of vascular stents during fatigue testing with radial loading
  249. Research Article
  250. Electrospun vascular grafts with anti-kinking properties
  251. Research Article
  252. Integration of temperature sensors in polyimide-based thin-film electrode arrays
  253. Research Article
  254. Use cases and usability challenges for head-mounted displays in healthcare
  255. Research Article
  256. Device- and service profiles for integrated or systems based on open standards
  257. Research Article
  258. Risk management for medical devices in research projects
  259. Research Article
  260. Simulation of varying femoral attachment sites of medial patellofemoral ligament using a musculoskeletal multi-body model
  261. Research Article
  262. Does enhancing consciousness for strategic planning processes support the effectiveness of problem-based learning concepts in biomedical education?
  263. Research Article
  264. SPIO processing in macrophages for MPI: The breast cancer MPI-SNLB-concept
  265. Research Article
  266. Numerical simulations of airflow in the human pharynx of OSAHS patients
Downloaded on 12.9.2025 from https://www.degruyterbrill.com/document/doi/10.1515/cdbme-2015-0024/html
Scroll to top button