Fluorescence study of 5-nitroisatin Schiff base immobilized on SBA-15 for sensing Fe3+

Muhammad Riza Ghulam Fahmi; Adroit T.N. Fajar; Nurliana Roslan; Leny Yuliati; Arif Fadlan; Mardi Santoso; Hendrik O. Lintang

doi:10.1515/chem-2019-0053

Artikel Open Access

Fluorescence study of 5-nitroisatin Schiff base immobilized on SBA-15 for sensing Fe³⁺

Muhammad Riza Ghulam Fahmi , Adroit T.N. Fajar , Nurliana Roslan , Leny Yuliati , Arif Fadlan , Mardi Santoso und Hendrik O. Lintang

Veröffentlicht/Copyright: 24. August 2019

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Abstract

N’-(5-nitro-2-oxoindolin-3-ylidene) thiophene-2-carbohydrazide (NH) was successfully synthesized as a ligand, then grafted onto the surface of mesoporous silica SBA-15via an aminopropyl bridge. The successful grafting of ligand NH onto the hybrid nanomaterial (SBA-15/APTES-NH) was confirmed by infrared spectroscopy. On excitation at 276 and 370 nm, the ligand NH and the hybrid nanomaterial SBA-15/APTES-NH showed a strong and narrow emission peak centered at 533 nm. By dispersing SBA-15/APTES-NH in an aqueous solution containing metal ions, the resulting solid materials showed a higher binding of NH sensing site to Fe³⁺ ions as compared to the others with a quench of the emission intensity up to 84%. This result showed that the hybrid nanomaterial is a potential chemosensor that requires development for the detection of metal ions.

Keywords: chemosensor; hybrid material; metal ions; SBA-15; Schiff base

1 Introduction

Amongst heavy metals, iron plays an important function in living organisms and their metabolism such as oxygen-carrying and the formation of the hemoglobin [1]. However, excessive Fe³⁺ in the human body causes various problems such as cancers and dysfunction of organs while an iron deficiency can lead to anemia [2,3]. For these reasons, detecting iron ions have been an interesting area of research. For example, several analytical techniques for detecting iron ions have been generally developed using instrumental techniques such as Voltammetry, Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES), and Flame Atomic Absorption Spectrometry (FAAS) [4,5]. However, these techniques become inaccessible because of some inherent limitations such as being expensive, complicated sample pretreatments and due to usage of harmful solvents [2,6]. Recently, fluorescent chemosensors have significantly became an interest because these compounds or materials can be used in environmental research with high sensing capabilities such as easy detection, quick response, good selectivity, high sensitivity, and low costs [7,8].

Schiff base derivatives have played an important role as a chemosensor due to their chromogenic and azomethine groups [9,10]. Schiff base could be easily prepared by condensation between a primary amine and an aldehyde or a ketone group [11]. The lone pair of electrons at the cyanide and carbonyl groups provided a good possibility for chelating to transition metal ions. It is due to the formation of π electrons in the six-membered rings [12, 13, 14]. Therefore, Schiff base can be applied as a chelating agent for the detection of many metal ions. For examples, Schiff base derived from isatin has been widely reported for chemosensors such as isatin N-phenylsemicarbazone [15], rhodamine-isatin [16], 2’,7’-diamino-2-oxo-1’,4’-dihydrospiro[indoline3,4’-quinoline]-3’-carbonitriles [17], and N-methyl isatin [18].

Functionalized mesoporous silica has gained wide attention due to their applications such as membranes, drug delivery, chemosensor, and biosensor [19, 20, 21, 22]. SBA-15, one of the mesoporous silica, is a promising material to be used as inorganic support because of the high thermal stability, large pore size and high surface area [20,23,24]. Besides that, the presence of OH groups from the silanol on the surface of SBA-15 can be attached by various organic chromophores [25,26]. Moreover, for chemosensor applications [27, 28, 29, 30, 31, 32, 33], the regularly arranged pores in its SBA-15 mesostructure can enhance the selectivity to particular guests like organic substance and/or metal ions [34]. For Schiff base ligands as fluorescent chemosensors in the hybrid mesoporous silica materials, several reports have been published for sensing Al³⁺ [35], Hg²⁺ [36], Pb²⁺ [37], Zn²⁺ [38, 39, 40], and Cu²⁺ ions [41, 42, 43]. In particular, Wang et al. [44] and Afshani et al. [45] have reported that the grafting of bis-Schiff base N,N′-(1,4-phenylenedimethyli-dyne)bis(1,4-benzenediamine) (PMBA) and salicylaldehyde with SBA-15 can be used for sensing Fe³⁺ at a less intense blue-emission peak of the binding site consisting of a broad peak. By using isatin-isonicotinohydrazide functionalized SBA-15, Lashgari et al. in 2017 [46] showed that the hybrid nanomaterial can be used as a chemosensor of the same metal ion. However, the sensing capability was only found up to 70% quenching of its less intense and broad emission peak at 420 nm. Hence, it is necessary to develop chemosensors with more bright emission especially in the area closed to near infrared so that the identification and evaluation can be easily carried out and is more sensitive. On the other hands, Schiff-base from 5-nitroisatin type fluorescent chemosensors have been rarely reported [44, 45, 46] and 2-thiophene carboxylic acid hydrazide was reported as Schiff base for the fluorescent probe of 2-hydroxy-1-naphthaldehyde in the detection of Al³⁺ ions with a broad green-emission at 476 nm [47]. To the best of our knowledge, 5-nitroisatin Schiff base immobilized on SBA-15 hybrid nanomaterials for sensing Fe³⁺ is one of the potential chemosensor with bright fluorescence and high sensing capability. Herein, we report the first example of hybrid fluorescent chemosensors with strong and intense emission at the green-to-red (533 nm) area using SBA-15 with a Schiff-base nitroisatin based on 2-thiophene carboxylic acid hydrazide, called as N’-(5-nitro-2-oxoindolin-3-ylidene) thiophene-2-carbohydrazide, for the detection of Fe³⁺ ions. In particular, the new hybrid chemosensor shows high sensing capability up to 84% with low limit of detection and high reusability.

2 Experimental

2.1 Materials and Method

The materials, 5-nitroisatin (Aldrich N17807), 2-thiophenecarboxylic acid hydrazide (Aldrich T1388), aquades, dimethyl sulfoxide anhydrous (Merck 8.02912), ethanol (Merck 1.00983), sulfuric acid, ethyl acetate, acetone, n-hexane, chloroform, and SBA-15 were obtained in the previous study [48]. Infrared spectra are measured using FT-IR JASCO 6800 with ATR disc, UV-Vis spectra were measured using spectrophotometer JASCO V-760, and fluorescence analysis were measured using spectrofluorometer JASCO FP-8500ST. ¹H-NMR spectra were obtained at 500 MHz and ¹³C-NMR spectra were measured at 125 MHz using JMN-ECA 500 NMR machine. DMSO-d6 was used as an internal standard and solvent. Mass spectra were obtained using Waters LCT Premier XE instrument.

2.2 Synthesis of Schiff base

Schiff base ligand NH was synthesized by diluting 5-nitroisatin (0.15 g; 0.80 mmol) in 20 mL of ethanol and placed in a round bottom flask as shown in scheme 1. Three drops of sulfuric acid were added and then refluxed for 20 minutes. 2-Thiophenocarboxylic acid hydrazide (0.11 g; 0.80 mmol) in 10 mL ethanol was added to the mixture and it was refluxed further at 78°C for 2 hours (the current reaction was monitored with thin layer chromatography). The mixture was cooled to room temperature and the solvent was evaporated. The remaining solid was washed with cold ethanol (2x5 mL), dried thoroughly desiccator, and identified by FT-IR, NMR and MS spectrometers.

Scheme 1

Synthesis route of N’-(5-nitro-2-oxoindolin-3-ylidene) thiophene-2-carbohydrazide.

2.3 Synthesis of SBA-15/APTES

The mesoporous silica, SBA-15, was prepared in the previous study [48]. 3-Aminopropyl triethoxysilane (APTES) was used as the silylation reagent on the aminopropyl grafting onto SBA-15. Typically, one gram of SBA-15 was mixed to APTES (2.2 mL) in 50 mL chloroform and then stirred at room temperature for 12 hours. After that, the mixture was filtered, washed with chloroform and dried at room temperature. The resulting white solid was characterized by using FT-IR spectrometer.

2.4 Synthesis of SBA-15/APTES-NH

For the grafting of an organic compound, SBA-15/APTES (200 mg) and ligand NH thiophene-2-carbohydrazide (57 mg) were refluxed in ethanol solution (50 mL) for 24 hours. This mixture was filtered with a Whatman paper and washed with ethanol until the filtrate did not show yellow color. The resulting yellow solid was dried at room temperature and characterized by FT-IR and fluorescent spectrometers.

2.5 Fluorescent Chemosensor of Metal Ions

Sensing properties of SBA-15/APTES-NH were evaluated by using the solid method. Iron ions in chloride salt (FeCl₃) were dissolved in water with a concentration of 50, 100, 150, and 200 mM. After that, 1 mL of Fe³⁺ ion was mixed with 5 mg of SBA-15/APTES-NH and sonicated for 5 minutes. The mixture was centrifuged for 15 minutes, decantated and dried at 50O_C. The resulting solid sample was measured their changes in emission and excitation by using fluorescence spectroscopy. Other metal ions such as Ca²⁺, Co²⁺, Cu²⁺, Fe³⁺, K⁺, Mg²⁺, Mn²⁺, and Zn²⁺ in 100 mM were also evaluated with the same experiment procedure.

3 Result and Discussion

The synthesis of ligand NH was prepared by adapting the previous method [49]. Typically, as shown in Scheme 1, 5-nitroisatin was refluxed with 2-thiophenocarboxylic hydrazide in ethanol under acidic conditions using sulfuric acid to give ligand NH in 92% yield. Figure 1 shows the FT-IR spectrum of the ligand NH, SBA-15, SBA-15/APTES and the hybrid materials SBA-15/APTES-NH. The vibration peaks at 3149 and 1529 cm^-1 were assigned to N-H and C=N functional groups, indicating the formation of Schiff base as the ligand NH. Other important vibration peaks of the ligand NH were identified at 1662 and 1340 cm^-1 for carbonyl (C=O) and C=C aromatic groups. Moreover, the ¹H-NMR spectrum shows a singlet signal of NH hydrazide proton at chemical shift (δ) of 13.12 ppm and NH isatin proton at δ of 11.93 ppm. In addition, aromatic protons have shown their signals at δ of 7.15, 7.31, 7.97, 8.10, 8.29 and 8.30 ppm with a number of protons for 6H from isatin and thiophene rings. Mass spectrum shows the molecular ion peaks [M+H]⁺ at m/z 317.3164 Da and [M+Na]⁺ at m/z 339.3615 Da. The calculation of exact mass for ligand NH shows the molecular ion peaks [M+H]⁺ at

Figure 1

FT-IR spectrum of SBA-15 (black line), SB-15/APTES (red line), SBA-15/APTES-NH (blue line) and ligand NH (pink line).

m/z 317.3000 Da and [M+Na]⁺ at m/z 339.2818 Da that are closed to the observed ones. These results confirm that the ligand NH has been successfully formed.

In the synthesis of hybrid nanomaterial, the unmodified SBA-15 was firstly characterized using FT-IR spectrometer. It showed the vibration bands at 3300-3750, 1080, 970-950 and 461 cm^-1 for OH, Si–O–Si, Si–OH, and Si–O, respectively. When compared with SBA-15, the intensity of silanol groups at 3467 cm^-1 was decreased in SBA-15/APTES concomitant with increasing intensity of N-H bands of the APTES aminopropyl groups. Besides that, the presence of original vibration bands in the range of 2881–2990 cm⁻¹ for stretching of methylene vibrations from the propyl chain were still observed, indicating the successful grafting of APTES with SBA-15 to give SBA-15/APTES. Moreover, since the characteristics of vibration peaks for ligand NH and SBA-15/APTES were still observed, the ligand NH was successfully grafted onto the surface of SBA-15/APTES to give SBA-15/APTES-NH.

Figure 2 shows the fluorescent studies of ligand NH and hybrid material SBA-15/APTES-NH. The fluorescence of these hybrid materials appears at a definite excitation wavelength because the ligand NH can produce strong fluorescence. Commonly, SBA-15 did not show fluorescence due to the absence of chromophore groups. By excitation at 276 and 370 nm for the ligand NH, it gave emission peaks centered at 308 and 533 nm from respective isatin and thiophene chromophores [47,50]. By using the same excitation peaks, the monitoring spectrum for the hybrid materials showed the same narrow and intense emission peak. Such small decrease in the emission intensity in the hybrid material can be observed due to the degree of loading for the organic moieties not only onto the surface but also in the silicate channels as found in many reports of functionalization mesoporous silica with functional groups [51].

Figure 2

Excitation (dash line) and emission (straight line) spectrum of (a) ligand NH and (b) hybrid material SBA-15/APTES-NH.

The sensing properties of SBA-15/APTES-NH were conducted by the solid method. Solid methods or solid-contact have major advantages such as minimizing waste from organic solvents when compared to chemosensors which were used as organic solvents such as dimethylsulfoxide and acetonitrile [52,53]. Besides that, the organic solvent can interfere with the sensing process and change the responsive optical properties of certain chemosensors [54]. Figure 3 shows that the changes in excitation and emission properties of hybrid material SBA-15/APTES-NH after getting mixed with the solution of 100 mM metal ions (Ca²⁺, Co²⁺, Cu²⁺, Fe³⁺, K⁺, Mg²⁺, Mn²⁺, and Zn²⁺). By using the same excitation for monitoring emission properties of the hybrid material, it was found that the SBA-15/APTES-NH showed a decrease in its emission intensities for Fe³⁺ in 77% (Figure 3a) and 84% (Figure 3b) at 276 and 374 nm. In this case, DI/I₀ described as the sensing capability of the host (SBA-15/APTES-NH) for sensing same guest (metal ions) [25,55] where the value DI is I-I₀, (I₀ is the fluorescent intensity for the only composite SBA-15/APTES-NH while I is the fluorescent intensity for the sensor with metal ions). As can be seen in Figure 4a, the largest ΔI/I₀ (approximately 0.84) is observed in the presence of Fe³⁺, whereas a small change was observed in the presence of other metal ions. Thus, hybrid material SBA-15/APTES-NH shows a remarkable sensitivity for the fluorescent chemosensor of Fe³⁺ ions.

Figure 3

Emission spectral changes of the hybrid material SBA-15/APTES-NH with excitation wavelengths at (a) 276 and (b) 370 nm after sensing various metal ions.

Figure 4

(a) Sensing capability (DI/I₀) of SBA-15/APTES-NH for the detection of various metal ions and (b) changes in emission intensity in the presence of a mixture of Fe³⁺ and Cu²⁺ in an equal concentration of 100 mM with an excitation at 370 nm.

Interestingly, as shown in Figure 4a, the SBA-15/APTES-NH showed the second highest in the decrease of emission intensity for sensing Cu²⁺ ions in 33% and 45% upon monitoring at 276 and 370 nm. Such sensing capability is almost half of the performance in the detection of Fe³⁺. Of interest to the real sample, the SBA-15/APTES-NH was used to detect the mixture of both ions with the same concentration (100 mM) in order to evaluate the selectivity and/or interference. Since the decrease of the emission intensity is between the response of the hybrid chemosensor for sensing sample containing Cu²⁺ and Fe³⁺ ions, the presence of Cu²⁺ ions in the mixture was found to reduce the performance of the hybrid material around 7% only in the detection of Fe³⁺ ions (as shown in Figure 4b). From this finding, it can also be concluded that the hybrid chemosensor is more selective to detect Fe³⁺ than Cu²⁺ ions with only small interference to the presence of Cu²⁺ ions.

The sensing capability of SBA-15/APTES-NH was studied by addition of various concentrations of Fe³⁺ ions in the range of 50-200 mM. Figure 5a and 5b shows the changes in the emission intensities of SBA-15/APTES-NH upon monitoring at excitation wavelengths of 276 and 370 nm. From that evaluation, the chemosensor showed gradually quenching of its emission intensity with an increasing concentration of Fe³⁺ ions up to 200 mM. Moreover, the Stern-Volmer plot (as shown in Figure 5c) with a variation of the concentration indicates that the

Figure 5

Effect of Fe³⁺ concentrations on the emission spectra changes of SBA-15/APTES-NH at (a) 276 and (b) 370 nm and (c) Stern-Volmer plot (wavelength excitation at 370 nm) between relative emission intensity at 533 nm as well as (d) changes in emission intensity with variation concentration of Fe³⁺ ions at 276 and 370 nm with SD error bars.

changes in emission intensities upon detection of the Fe³⁺ ions are linearly dependent on the increase in the concentration of the guest for both excitation wavelengths. Such changes can be identified as dynamical interaction of the sensing site toward the presence of Fe³⁺ ions. The limit of detection (LOD) of SBA-15/APTES-NH can be calculated with the equation LOD = 3 SD/K_sv [56,57], where SD is the standard deviation of the blank signals and K_sv is the quenching constant of Stern-Volmer. The result of SD and K_sv is 0.006905426 and 0.0139 mM^-1, respectively. Therefore, the detection limit of SBA-15/APTES-NH is 1.49 mM, which indicates that the SBA-15/APTES-NH is potentially used for detection of Fe³⁺ ions even in the lower concentration. Otherwise, the SBA-15/APTES-NH sensor can be potentially applied to detect Fe³⁺ ions in the environmental and pharmaceutical fields [58,59]. Moreover, limit of quantification (LOQ) can be also calculated with the equation of LOQ = 10 SD/K_sv [60]. The LOQ value of SBA-15/APTES-NH is 6.32 mM. By using the calibration curve as the relative emission intensity of SBA-15/APTES-NH at 533 nm versus Fe³⁺ concentration, the quantitative analysis can be performed in the presence of real samples. In the linear range between 50 to 200 mM, the calibration curve is not straightforward with a high relative coefficient due to the inhomegenous distribution of organic moieties in the grafting with SBA-15/APTES. Such drawback in the loading of organic functional groups has been discussed in many reports [52]. Of interest, the good reproducibility of SBA-15/APTES-NH was shown with the small RSD value in 2.7 and 7.4% for both excitation wavelengths of 276 and 370 nm (Figure 5d).

Reusability testing is important factors for the development of novel chemosensors in practical applications. Previously, chemosensors for the detection of Fe³⁺ ions based on functionalized SBA-15 have not yet reported the reversibility testing [44,61]. In this study, the reversibility of the Fe³⁺ was treated by the addition of the binding agent of potassium thiocyanate (KSCN) in hydrochloric acid (HCl) (pH = 1) to the hybrid chemosensor consisting of Fe³⁺ ions. The testing was performed until the color of the solution of KSCN in HCl changes from red to a colorless solution. As shown in Figure 6, the hybrid chemosensor can be recycled up to three times with only a small decrease in the performance. Such reusability result is an important achievement for the fabrication of Fe³⁺ fluorescent chemosensors.

Figure 6

Reversibility testing with changes in fluorescent intensity of SBA-15/APTES-NH at 533 nm upon addition to KSCN in HCl solution.

The FT-IR spectrum of the SBA-15/APTES-NH with the absence and presence of Fe³⁺ ions was particularly analyzed in the range of 1800-400 cm^-1 using ATR (Figure 7a). The FT-IR spectrum of SBA-15/APTES-NH shows characteristic vibration peaks at 1707, 1662, 1341 and 751 cm^-1, which are assigned to the vibrations of carbonyl amide,

Figure 7

(a) FT-IR spectrum of the SBA-15/APTES-NH with the absence and presence of Fe³⁺ ions and (b) Job’s plot for Fe³⁺ ions versus nett volume of ligand NH to Fe³⁺ ion.

C=N, C-N and C-S groups, respectively. Moreover, the vibration peak of N-H bending from isatin ring, Schiff base, and aminopropyl (from APTES) groups were observed at 1624, 1603, and 1530 cm^-1. Upon addition of Fe³⁺ ions to the chemosensor, the N-H bending of Schiff base and C=O peaks slightly shifted with small changes in their intensities from 1707 to 1706 cm^-1, 1603 to 1605 cm^-1 and 1530 to 1529 cm^-1. In shall be noted that the vibration peak of the N-H from Schiff base was increased in 1.25 times of its intensity while vibration peak for C=N was broadened and vibration peaks for C-N and C-S were reduced significantly. Such changes clearly suggest that Fe³⁺ ions have formed strong interactions with the Schiff base and thiophene ring while a weak interaction can also be possible with aminopropyl-bridged nitro isatin group [53]. Further analysis with Job’s plot for binding analysis of the ligand NH to Fe³⁺ ions in the solution phase as shown in Figure 7b confirmed that the interaction were initially closed to 1:1 of Fe³⁺ ions to ligand NH and then gradually changed to 1:4 to form the stable binding interactions. Based on the above finding, the interactions of Fe³⁺ ions with the sensing site of hybrid material SBA-15/APTES-NH can be proposed as shown in Figure 8.

Figure 8

Proposed plausible mechanism for the interaction of ligand NH as the sensing site in the hybrid material SBA-15/APTES-NH for the detection of Fe³⁺ ions.

4 Conclusion

The organic-inorganic hybrid SBA-15/APTES-NH was synthesized and characterized using the mesoporous silica SBA-15 and the new nitroisatin (ligand NH). This hybrid SBA-15/APTES-NH was successfully applied as a chemosensor and showed a good sensing capability towards Fe³⁺ ions from its emission changes at 533 nm with an quenching phenomenon up to 84%, low LOD, and RSD as well as high reusability. From the Stern-Volmer diagram, the SBA-15/APTES-NH showed a linear graphic with the excitation of wavelengths at 276 and 370 nm for a good relationship of the emission changes with the increasing concentration of Fe³⁺ ions. All of the obtained results suggest that the new hybrid material SBA-15/APTES-NH with an intense and narrow emission peak is a potential fluorescent chemosensor for the detection of Fe³⁺ ions.

Acknowledgment

The authors thank Ministry of Research, Technology and Higher Education, The Republic of Indonesia for financial support through Higher Education Excellent Applied Research Grant (Penelitian Terapan Unggulan Perguruan Tinggi) 2019 with Agreement No. 006/MACHUNG/LPPM/SP2H-LIT-MULTI/III/2019. This research was partially financed by COMSTECH-TWAS Joint Research Grants Programme with a contract agreement number of 17-139RG/MSN/AS_C-FR3240300067.

Conflict of interest: Authors declare no conflict of interest.

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Received: 2018-09-11

Accepted: 2019-02-12

Published Online: 2019-08-24

This work is licensed under the Creative Commons Attribution 4.0 Public License.

Artikel in diesem Heft

https://doi.org/10.1515/chem-2019-0053

Schlagwörter für diesen Artikel

chemosensor; hybrid material; metal ions; SBA-15; Schiff base

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