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Green synthesis, characterization, and evaluation of antibacterial activities of cobalt nanoparticles produced by marine fungal species Periconia prolifica

  • Mohamed S. Hodhod , Abdel-Rhman Z. Gaafar ORCID logo EMAIL logo , Bandar M. AlMunqedhi and Abdalla Elzein
Published/Copyright: October 17, 2023
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Open Chemistry
From the journal Open Chemistry Volume 21 Issue 1

Abstract

Bio-nanotechnology provided an ecofriendly synthesis route for various metal nanoparticles by utilizing different biological systems, especially microorganisms, which act as an alternative to the physical and chemical methods. Cobalt nanoparticles (CoNPs) were synthesized by Periconia prolifica (Anast.) from intertidal decayed wood samples from the mangrove tree Avicennia marina (Forsk.) of Tarout Island, located in the Arabian Gulf Sea of Saudi Arabia. CoNPs were characterized by X-ray diffraction, transmission electron microscopy, Fourier-transform infrared spectroscopy, and atomic force microscope. The extract of the culture of P. prolifica was used as a bio-reductant agent, during which the culturing process proved to have great potential to be applied on an industrial scale, as it was a time-saving, inexpensive, and adequate amount of biomass being produced at the end of the process. A preliminary antibacterial test against one Gram-positive resistant bacteria (i.e., Methicillin-resistant Staphylococcus aureus) and other Gram-negative resistant bacteria was performed using a disk diffusion assay. The antibacterial results witnessed the key role that metal size plays in causing higher activity and also in causing severe damage to the bacterial cells by inactivating its membrane permeability, leading to bacterial cell death.

Keywords: marine fungi; Periconia prolifica ; CoNPs; characterization; antibacterial activity

1 Introduction

Nanotechnology opened a new frontier for reexploring the properties of metals by manipulating their size, chemical composition, and dimensions to alter their effect [1]. Various methodologies (i.e., chemical and physical routes) are now available to synthesize nanomaterials that can effectively kill drug-resistant bacteria. However, these methods suffer from a few drawbacks due to concerns raised over environmental pollution, since the above-mentioned routes generate massive amounts of hazardous toxic by-products, in addition to high cost and higher reaction conditions (temperature, pH, etc.) [2]. Recently, the development of cost-effective metal nanoparticles (m-NP) based on the principles of green chemistry (i.e., nano-biotechnology) was achieved through the exploitation of biological systems such as plants, algae, fungi, and bacteria [3,4,5]. Among the biological agents, fungi possessed higher rates of tolerance and metal bioaccumulation abilities, which are crucial characteristics for the synthesis of nanoparticles. Another important benefit of using fungi in the pharmaceutical industry is the ease of scaling up the synthesis process, making the entire process more cost-effective [6]. Thus, there is a demand for the search for new fungal resources and their utilization for the production of nanomaterials.

Marine fungi provide great potential in biotechnological applications [7], as they are a unique ecological group that differs from its terrestrial and freshwater counterparts in both physiological and morphological requirements [8]; they are found exclusively in oceans and seas of the world colonizing a wide variety of decaying plant material ranging from mangroves, drift and intertidal wood, algae, seagrasses, corals, and various marine animals [9]. Periconia prolifica has been reported from different substrata in Saudi Arabia, including Jeddah driftwood [10], mangroves wood [11], and from the coast of the Red Sea coast, and seawater and sea foam from the Arabian Gulf coast [12]. The current effort focuses on two important points: (i) the green synthesis of cobalt nanoparticles (CoNPs) utilizing a fungal extract of P. prolifica, which will aid in developing nanostructures, minimize light recombined activity, and boost reactive oxygen species activities. (ii) Evaluation of the effect of CoNPs on eradicating Escherichia coli and Methicillin-resistant Staphylococcus aureus (MRSA) bacterial strains.

2 Materials and methods

2.1 Fungal isolation and bacterial growth conditions

The marine fungal species P. prolifica was recorded from intertidal decayed wood samples of the mangrove tree Avicennia marina (Forsk.) of Tarout island located at the Arabian Gulf Sea of Saudi Arabia, with coordinates of (26°35′43″N – 50°3′51″E). The isolated fungi were identified based on the morphological characteristics of the fruiting structures (i.e., conidiomata, conidiogenesis, conidiophores, and conidia for anamorphic fungi) [13]. The conidia were mounted in seawater for photography, measurements, and description using the compound microscope (Motic ACCU-scope 3002, China) and examined using a scanning electron microscope (SEM) (JOEL, JSM-6380 LA, Tokyo, Japan). The germinated conidia were then transferred to new Petri plates of glucose yeast agar with sterile forceps and incubated at 25°C for 1–2 weeks in the dark [14]. Pure cultures of isolated fungi were preserved in a glycerol solution (10%) at −80°C and deposited at the Department of Botany and Microbiology of Science, King Saud University.

The test organisms included Gram-negative resistant E. coli ATCC BAA-196 and Gram-positive MRSA ATCC-33591. Pathogenic bacterial strains were grown for 24 h on Muller-Hinton agar plates, and a cell suspension was prepared in physiological saline (phosphate buffer saline).

2.2 Biosynthesis of CoNPs

For nanoparticle green synthesis, P. prolifica was cultivated in 250 Erlenmeyer flasks containing 100 ml of YMG 50% seawater medium. Cultured flasks were incubated in a rotating shaker at 200 rpm for 5 days at 25°C. Cobalt metal in the form of cobalt chloride (CoCl2) was introduced to the supernatant to test extracellular bio-reduction [15]. The biosynthesis of nanoparticles was carried out using 5 mM of the metal salt solution followed by rationally adding supernatant (i.e., 90 ml of metal salt solution + 10 ml of supernatant), where instant development of color occurs (i.e., dark yellow) indicating the bio-reduction of metal salt. The flasks were then placed on a rotating shaker (200 rpm) at 25°C for 72 h in the dark to complete the reduction process (Figure 1).

Figure 1 The proposed mechanism of biosynthesis of CoNPs via P. prolifica extract.
Figure 1

The proposed mechanism of biosynthesis of CoNPs via P. prolifica extract.

2.3 Characterization of Co-NPs

2.3.1 Ultraviolet-visible (UV–vis) spectroscopy

CoNP biosynthesis was monitored by measuring 1 ml of CoCl2-treated cell-free filtrate (CFF) at regular intervals using a UV spectrophotometer (UV-1800 Shimadzu Spectrophotometer, Japan).

2.4 X-ray diffraction (XRD)

The average mean size of Co-NPs was determined by XRD spectroscopy (XRD-Ultima IV Rigaku, United States of America) on films of the respective solutions drop-coated onto glass substrates on an XRD machine. The Scherer equation d = 0.9 λ / β cos θ was used to estimate the mean size of the nanoparticles produced, where d is the mean diameter of the nanoparticles, λ is the wavelength of the X-ray radiation source, β is the full angular width at half maximum of the XRD peak at the diffraction angle, and θ is the Bragg angle [16].

2.5 Transmission electron microscopy (TEM)

The morphology of the synthesized CoNPs including their shape and size was analyzed and measured using a TEM instrument (JEOL-JEM-1011, Tokyo, Japan). The sample was prepared by drop-coating nanoparticle solutions (100%) onto carbon-coated copper TEM grids. The films on the TEM grids were allowed to stand for 2 min, and the grid was then allowed to dry before measurement.

2.6 Fourier transform infrared (FTIR) spectroscopy

CoNP analysis was performed using FTIR spectroscopy (Perkin-Elmer 1000 FT-IR, USA), and dry powders of the nanoparticles were obtained in the following manner. The biosynthesized nanoparticles were centrifuged at 14,000 rpm for 15 min, after which the pellet was re-dispersed in sterile distilled water to remove any uncoordinated biological molecules. The process of centrifugation and redistribution in sterile distilled water was repeated three times to ensure better separation of free entities from the m-NPs. The purified pellets were then dried, and the powders were subjected to FTIR spectroscopy measurement.

2.7 Antibacterial activity

A preliminary test was carried out against one Gram-positive resistant bacteria (i.e., MRSA) and other Gram-negative resistant bacteria (i.e., E. coli) using disk diffusion assay [17]. To determine the effect of the antibacterial potential possessed by the synthesized m-NPs, an atomic force microscope (AFM) was applied to determine the effect of CoNPs on the bacterial cells.

3 Results and discussion

Periconia prolifica has been reported from different geographical locations around the world, including Egypt, Saudi Arabia, Kuwait, Ghana, South Africa, Brazil, Malaysia, Indonesia, Japan, China, Mexico, the USA, and Taiwan; the substrates reported comprised decayed intertidal mangrove wood and seedlings [10,18,19]. P. prolifica conidia is characterized by 1-celled (6–13 × 20 μm), ovoid, smooth, and light brown with a reddish tint (Figure 2).

Figure 2 P. prolifica. (a) and (b) Bright-field light micrographs (from the holotype mounted in water). (c) and (d) SEM. (c) Group of smooth-walled conidia. (d) Magnified conidia. (e) Dissecting microscope, conidia on the wood surface. Bars: A = 30 μm, C = 5 µm, B and D = 2 µm, E = 500 µm.
Figure 2

P. prolifica. (a) and (b) Bright-field light micrographs (from the holotype mounted in water). (c) and (d) SEM. (c) Group of smooth-walled conidia. (d) Magnified conidia. (e) Dissecting microscope, conidia on the wood surface. Bars: A = 30 μm, C = 5 µm, B and D = 2 µm, E = 500 µm.

Spectral absorption of CoNP (Figure 3) was produced using CFF of P. prolifica (purple curve), and the dark yellow color developed in the solution resulting from the reduction of the metal salt. The blue curve indicates the control group, which has a transparent color in the solution as an indicator of CoNPs. The high optical density of the CoNP solution was recorded at 420 nm, while the control group did not have a peak at 300–800 nm. The UV visible spectroscopy results of CoNPs synthesized by P. prolifica showed a very close absorbance of 420 nm, indicating a surface plasmon resonance, which indicates that the synthesized nanoparticle sizes are smaller than 100 nm. The reading absorbance is due to the excitation of electrons in the conductive band around the nanoparticle surface [20]. The change in absorbance reading indicates that the produced nanoparticles are of different shapes and sizes [21].

Figure 3 UV–visible spectra of CoNPs synthesized using P. prolifica CFF (purple curve), and the control group is represented herein by the blue curve.
Figure 3

UV–visible spectra of CoNPs synthesized using P. prolifica CFF (purple curve), and the control group is represented herein by the blue curve.

The CoNp diffraction peaks (Figure 4) corresponded to the characteristic face-centered cubic cobalt lines indexed as (2.389), (2.068), and (1.386) that were observed in these samples at diffraction angles of 37.8°, 43.9°, and 76.8°, respectively. The mean size of the CoNPs estimated by XRD data is 21 nm. The CoNP data obtained perfectly matched the database Joint Committee on Powder Diffraction Standards (JCPDS) database file No. 73-2134 (23).

Figure 4 XRD pattern of CoNPs synthesized by P. prolifica.
Figure 4

XRD pattern of CoNPs synthesized by P. prolifica.

The TEM results presented in Figure 5 of the P. prolifica CoNP appeared to be a pentagonal shape with an average mean size of 21 nm. The results of both XRD and TEM matched perfectly with each other, confirming the characteristics and properties of the produced m-NPs [23,24].

Figure 5 TEM micrograph of CoNPs showing the shape and particle size estimation, where cobalt takes a pentagonal shape with an average mean size of 21 nm.
Figure 5

TEM micrograph of CoNPs showing the shape and particle size estimation, where cobalt takes a pentagonal shape with an average mean size of 21 nm.

FTIR spectroscopy (Figure 6) was used to determine the chemical functional groups in the cobalt m-NPs and proteins surrounding the synthesized nanoparticles as stabilization agents.

Figure 6 FTIR of the synthesized CoNPs.
Figure 6

FTIR of the synthesized CoNPs.

FTIR analysis involved in the formation of CoNPs included the presence of peaks at 3,427 and 3,273 cm−1 in P. prolifica corresponding to the hydroxyl group of polyphenolic compounds. The bands shown at 2,963, 2,924, and 2,851 cm−1 are assigned to –CN stretching vibrations. The presence of peaks at 1,630 and 1,535 cm−1 corresponds to the C═O and NH (primary amine) of peptide linkage, respectively. The band for 1,454 and 1,406 cm−1 was assigned to the stretching of the aromatic amino group. The peak shown at 1,234 cm−1 corresponds to the presence of aromatic rings. FTIR analysis confirmed the presence of proteins surrounding and coating synthesized CoNPs, which act as reducing agents and stabilizing agents during the biosynthesis process [25,26].

The results of the CoNP characterization showed similar observations to many studies. The UV visible spectroscopy results were compatible with many reports. The distinguishing characteristic of CoNPs is to exhibit a surface plasmon absorption band in the range of 350–550 nm [27,28]. The change in absorbance reading indicates that the produced nanoparticles are of different shapes and sizes [21]. The XRD results of the obtained CoNP data were matched perfectly with the JCPDS file of database no. 73–2134 [22], which was also reported in other studies with slightly different angles [29–31]. The TEM results of the CoNPs appeared to be pentagonal in shape with an average mean size of 21 nm. A size similar to that observed in other studies [31,32]. FTIR analysis confirmed the presence of proteins surrounding and coating synthesized CoNPs, which act as reducing agents and stabilizing agents during the biosynthesis process [27,33].

The preliminary antibacterial activity test (Figure 7, Table 1) against Gram-negative resistant E. coli and Gram-positive MRSA showed an inhibition zone of 13 and 15 mm, respectively.

Figure 7 Agar disc diffusion method using CoNPs against (a) E. coli and (b) MRSA.
Figure 7

Agar disc diffusion method using CoNPs against (a) E. coli and (b) MRSA.

Table 1

Minimum inhibitory concentration (MIC) of CoNPs against Gram-positive and negative bacterial species

Bacterial species Gram MIC (μg/ml) Inhibition zone
E. coli −ve 4  ±  0 13.4  ±  1.34
MRSA +ve 2  ±  0 15.2  ±  1.3

The CoNPs were shown to have supreme antibacterial activity (Figure 8). As Co+ small particles resulted in increased surface area, which led to better surface contact with bacteria and hence better bactericidal effect [34–36]. AFM images at time zero showed that Co+ ions are believed to create an electrostatic bond to the bacterial outer surface, where once that contact is made, the bacterial cells are oxidized and damaged instantly. This is due to the release of CoNP ions that react directly with the thiol (–SH) group of proteins located at the bacterial cell and protrude through the cell membrane. Therefore, inactivating membrane permeability leads to bacterial cell death [37]. Antibacterial results witnessed the key role played by metal size in causing higher activity and in targeting behavior mechanisms. CoNP activity has been reported in many studies; mechanisms of action include its surface binding to bacterial membranes, therefore increasing the generation time by decreasing cell mobility [38]. Other mechanisms involving the stimulation of reactive oxygen formation, such as super-oxide (−O2) and hydrogen peroxide (H2O2), result in more damage to the cell through essential proteins, genomic and plasmid DNA degradation [39–43].

Figure 8 (a)–(d) AFM using CoNPs against E. coli and MRSA at time = 0. (a) and (b) Aggregates of bacterial cells taken at a lower magnification of E. coli and MRSA respectively, (c) and (d) Magnified bacterial cells of E. coli and MRSA, respectively.
Figure 8

(a)–(d) AFM using CoNPs against E. coli and MRSA at time = 0. (a) and (b) Aggregates of bacterial cells taken at a lower magnification of E. coli and MRSA respectively, (c) and (d) Magnified bacterial cells of E. coli and MRSA, respectively.

4 Conclusion

The economic synthesis of stable pentagonal CoNPs via new biological resources such as marine fungi for use as antibacterial agents was very promising. The extract of the culture of P. prolifica was used as a bio-reductant agent, during which the culturing process proved to have great potential to be applied on an industrial scale, as it was a timesaving, cheap, and adequate amount of biomass being produced at the end of the process. The presence of proteins was detected through FTIR, which was found to coat the synthesized CoNPs, which act as reducing and stabilizing agents in the reduction process. Although the produced nanoparticles were of moderate size, they revealed elevated antibacterial activity. AFM imaging was of great aid in showing the mechanism of action on the bacterial cell surfaces, which was revealed by their swelling due to the inactivation of the cell membrane permeability, resulting in eventual bacterial death. Further in-depth studies must be conducted using other marine fungal species, and other biotechnological applications could be performed including anticancer, antioxidant, and insecticidal activity.

# Both authors are considered as first authors.

tel: +966-540329167

Acknowledgments

The authors appreciate the Researchers Supporting Project number RSPD2023R686, King Saud University, Riyadh, Saudi Arabia.

  1. Funding information: The Researchers Supporting Project number RSPD2023R686, King Saud University, Riyadh, Saudi Arabia.

  2. Author contributions: All authors contributed to the preparation of the manuscript and the discussion. M.S.H. and A.-R.Z.G. gave the idea, supervised the experiments, and reviewed the final draft of the manuscript. A-R.Z.G., M.S.H., and B.M.A. performed the experiments, analyzed the data, and wrote the first draft. A.Z. helped in data analysis. M.S.H. helped in field data collection.

  3. Conflict of interest: On behalf of all authors, the corresponding author states that there is no conflict of interest.

  4. Data availability statement: All data generated or analyzed during this study are included in this published article.

References

[1] Levy SB, Marshall B. Antibacterial resistance worldwide: causes, challenges and responses. Nat Med. 2004;10(12s):S122.10.1038/nm1145Search in Google Scholar PubMed

[2] Soufi A, Hajjaoui H, Elmoubarki R, Abdennouri M, Qourzal S, Barka N. Spinel ferrites nanoparticles: synthesis methods and application in heterogeneous Fenton oxidation of organic pollutants–a review. Appl Surf Sci Adv. 2021;6:100145.10.1016/j.apsadv.2021.100145Search in Google Scholar

[3] Nachiyar V, Sunkar S, Prakash P. Biological synthesis of gold nanoparticles using endophytic fungi. Der Pharma Chem. 2015;7(11):31–8.Search in Google Scholar

[4] Ottoni CA, Simões MF, Fernandes S, Dos Santos JG, Da Silva ES, de Souza RFB, et al. Screening of filamentous fungi for antimicrobial silver nanoparticles synthesis. AMB Express. 2017;7(1):31.10.1186/s13568-017-0332-2Search in Google Scholar PubMed PubMed Central

[5] Shende S, Ingle AP, Gade A, Rai M. Green synthesis of copper nanoparticles by Citrus medica Linn.(Idilimbu) juice and its antimicrobial activity. World J Microbiol Biotechnol. 2015;31(6):865–73.10.1007/s11274-015-1840-3Search in Google Scholar PubMed

[6] Saxena J, Sharma PK, Sharma MM, Singh A. Process optimization for green synthesis of silver nanoparticles by Sclerotinia sclerotiorum MTCC 8785 and evaluation of its antibacterial properties. SpringerPlus. 2016;5(1):1–10.Search in Google Scholar

[7] Hodhod MSE-D, Gaafar A-RZ, Alshameri A, Qahtan AA, Noor A, Abdel-Wahab M. Molecular characterization and bioactive potential of newly identified strains of the extremophilic black yeast Hortaea werneckii isolated from Red Sea mangrove. Biotechnol Biotechnol Equip. 2020;34(1):1288–98.10.1080/13102818.2020.1835535Search in Google Scholar

[8] Jones EG. Marine fungi: some factors influencing biodiversity. Fung Divers. 2000;4:53–73.Search in Google Scholar

[9] Jones EG, Pang K-L. Tropical aquatic fungi. Biodivers Conserv. 2012;21:2403–23.10.1007/s10531-011-0198-6Search in Google Scholar

[10] Aleem A. A contribution to the study of seagrasses along the Red Sea coast of Saudi Arabia. Aquat Botany. 1979;7:71–8.10.1016/0304-3770(79)90009-3Search in Google Scholar

[11] Hodhod MS. Molecular Systematics of Marine Fungi Isolated from Yanbu Mangroves in the Kingdom of Saudi Arabia. Saudi Arabia: King Saud University; 2013.Search in Google Scholar

[12] Bokhary H, Moslem M, Parvez S. Marine fungi of the Arabian Gulf coast of Saudi Arabia. Microbiologica (Bologna). 1992;15(3):281–9.Search in Google Scholar

[13] Jones EG, Suetrong S, Sakayaroj J, Bahkali AH, Abdel-Wahab MA, Boekhout T, et al. Classification of marine ascomycota, basidiomycota, blastocladiomycota and chytridiomycota. Fungal Diversity. 2015;73:1–72.10.1007/s13225-015-0339-4Search in Google Scholar

[14] Abdel-Wahab MA, Bahkali AH, Jones EG, Elgorban AM, Abdel-Aziz FA, Hodhod MS, et al. Two new species of Kallichroma (Bionectriaceae, Hypocreales) from Saudi Arabian mangroves. Phytotaxa. 2016;260(1):66–74.10.11646/phytotaxa.260.1.7Search in Google Scholar

[15] Das VL, Thomas R, Varghese RT, Soniya E, Mathew J, Radhakrishnan E. Extracellular synthesis of silver nanoparticles by the Bacillus strain CS 11 isolated from industrialized area. 3 Biotech. 2014;4(2):121–6.10.1007/s13205-013-0130-8Search in Google Scholar PubMed PubMed Central

[16] Cullity BD. Elements of X-ray diffraction. Mass: Addison Wesley; 1978.Search in Google Scholar

[17] Balouiri M, Sadiki M, Ibnsouda SK. Methods for in vitro evaluating antimicrobial activity: A review. J Pharm Anal. 2016;6(2):71–9.10.1016/j.jpha.2015.11.005Search in Google Scholar PubMed PubMed Central

[18] Abdel-Wahab MA. Diversity of marine fungi from Egyptian Red Sea mangroves. Bot Mar. 2005;48(1):348–55.10.1515/bot.2005.047Search in Google Scholar

[19] Pang K-L, Jheng J-S, Jones EG. Marine mangrove fungi of Taiwan. Chilung: National Taiwan Ocean University; 2011. p. 1–131.Search in Google Scholar

[20] Fultz B, Howe JM. Transmission electron microscopy and diffractometry of materials. Germany: Springer Berlin Heidelberg; 2012.10.1007/978-3-642-29761-8Search in Google Scholar

[21] Desai R, Mankad V, Gupta SK, Jha PK. Size distribution of silver nanoparticles: UV-visible spectroscopic assessment. Nanosci Nanotechnol Lett. 2012;4(1):30–4.10.1166/nnl.2012.1278Search in Google Scholar

[22] Ranganatha S, Munichandraiah N. Synthesis and performance evaluation of novel cobalt hydroxychlorides for electrochemical supercapacitors. J Solid State Electrochem. 2017;21(4):939–46.10.1007/s10008-016-3443-9Search in Google Scholar

[23] Chicea D, Indrea E, Cretu C. Assesing Fe3O4 nanoparticle size by DLS, XRD and AFM. J Optoelectron Adv Mater. 2012;14(5):460.Search in Google Scholar

[24] Hu C, Zhang Z, Liu H, Gao P, Wang ZL. Direct synthesis and structure characterization of ultrafine CeO2 nanoparticles. Nanotechnology. 2006;17(24):5983.10.1088/0957-4484/17/24/013Search in Google Scholar

[25] Daima HK, Selvakannan P, Shukla R, Bhargava SK, Bansal V. Fine-tuning the antimicrobial profile of biocompatible gold nanoparticles by sequential surface functionalization using polyoxometalates and lysine. PLoS one. 2013;8(10):e79676.10.1371/journal.pone.0079676Search in Google Scholar PubMed PubMed Central

[26] Saxena J, Sharma PK, Sharma MM, Singh A. Process optimization for green synthesis of silver nanoparticles by Sclerotinia sclerotiorum MTCC 8785 and evaluation of its antibacterial properties. SpringerPlus. 2016;5(1):861.10.1186/s40064-016-2558-xSearch in Google Scholar PubMed PubMed Central

[27] Bibi I, Nazar N, Iqbal M, Kamal S, Nawaz H, Nouren S, et al. Green and eco-friendly synthesis of cobalt-oxide nanoparticle: Characterization and photo-catalytic activity. Adv Powder Technol. 2017;28(9):2035–43.10.1016/j.apt.2017.05.008Search in Google Scholar

[28] Jain PK, Lee KS, El-Sayed IH, El-Sayed MA. Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. J Phys Chem B. 2006;110(14):7238–48.10.1021/jp057170oSearch in Google Scholar PubMed

[29] Dhas NA, Raj CP, Gedanken A. Synthesis, characterization, and properties of metallic copper nanoparticles. Chem Mater. 1998;10(5):1446–52.10.1021/cm9708269Search in Google Scholar

[30] Nazeruddin G, Prasad N, Prasad S, Garadkar K, Nayak AK. In-vitro bio-fabrication of silver nanoparticle using Adhathoda vasica leaf extract and its anti-microbial activity. Phys E: Low-dimensional Syst Nanostruct. 2014;61:56–61.10.1016/j.physe.2014.02.023Search in Google Scholar

[31] Salavati-Niasari M, Khansari A, Davar F. Synthesis and characterization of cobalt oxide nanoparticles by thermal treatment process. Inorganica Chim Acta. 2009;362(14):4937–42.10.1016/j.ica.2009.07.023Search in Google Scholar

[32] Nethravathi C, Sen S, Ravishankar N, Rajamathi M, Pietzonka C, Harbrecht B. Ferrimagnetic nanogranular Co3O4 through solvothermal decomposition of colloidally dispersed monolayers of α-cobalt hydroxide. J Phys Chem B. 2005;109(23):11468–72.10.1021/jp050725vSearch in Google Scholar PubMed

[33] Fischer UA, Carle R, Kammerer DR. Identification and quantification of phenolic compounds from pomegranate (Punica granatum L.) peel, mesocarp, aril and differently produced juices by HPLC-DAD–ESI/MSn. Food Chem. 2011;127(2):807–21.10.1016/j.foodchem.2010.12.156Search in Google Scholar PubMed

[34] Cho K-H, Park J-E, Osaka T, Park S-G. The study of antimicrobial activity and preservative effects of nanosilver ingredient. Electrochim Acta. 2005;51(5):956–60.10.1016/j.electacta.2005.04.071Search in Google Scholar

[35] Panyala NR, Peña-Méndez EM, Havel J. Silver or silver nanoparticles: a hazardous threat to the environment and human health? J Appl Biomed (De Gruyter Open). 2008;6(3):117–29.10.32725/jab.2008.015Search in Google Scholar

[36] Prabhu S, Poulose EK. Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects. Int Nano Lett. 2012;2(1):32.10.1186/2228-5326-2-32Search in Google Scholar

[37] Zhang H, Chen G. Potent antibacterial activities of Ag/TiO2 nanocomposite powders synthesized by a one-pot sol− gel method. Environ Sci Technol. 2009;43(8):2905–10.10.1021/es803450fSearch in Google Scholar PubMed

[38] Vidya R, Venkatesan K. Preparation and characterization of zinc ferrite (ZnFe2O4) nanoparticles using self-propagated combustion route and evaluation of antimicrobial activity. Res J Pharm Biol Chem Sci. 2015;6(1):537–42.Search in Google Scholar

[39] Chatterjee AK, Chakraborty R, Basu T. Mechanism of antibacterial activity of copper nanoparticles. Nanotechnology. 2014;25(13):135101.10.1088/0957-4484/25/13/135101Search in Google Scholar PubMed

[40] Dupont CL, Grass G, Rensing C. Copper toxicity and the origin of bacterial resistance—new insights and applications. Metallomics. 2011;3(11):1109–18.10.1039/c1mt00107hSearch in Google Scholar PubMed

[41] Hashim M, Shirsath SE, Meena S, Kotnala R, Parveen A, Roy AS, et al. Investigation of structural, dielectric, magnetic and antibacterial activity of Cu–Cd–Ni–FeO4 nanoparticles. J Magn Magn Mater. 2013;341:148–57.10.1016/j.jmmm.2013.04.024Search in Google Scholar

[42] Sawai J. Quantitative evaluation of antibacterial activities of metallic oxide powders (ZnO, MgO and CaO) by conductimetric assay. J Microbiol Methods. 2003;54(2):177–82.10.1016/S0167-7012(03)00037-XSearch in Google Scholar

[43] Xavier S, Cleetus H, Nimila P, Thankachan S, Sebastian R, Mohammed E. Structural and antibacterial properties of silver substituted cobalt ferrite nanoparticles. Res J Pharm Biol Chem Sci. 2014;5(5):364–71.Search in Google Scholar
Received: 2023-09-06
Revised: 2023-09-22
Accepted: 2023-09-25
Published Online: 2023-10-17

© 2023 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  26. Determination of nicotine content in locally produced smokeless tobacco (Shammah) samples from Jazan region of Saudi Arabia using a convenient HPLC-MS/MS method
  27. Changes in oxidative stress markers in pediatric burn injury over a 1-week period
  28. Integrated geophysical techniques applied for petroleum basins structural characterization in the central part of the Western Desert, Egypt
  29. The impact of chemical modifications on gamma-ray attenuation properties of some WO3-reinforced tellurite glasses
  30. Microwave and Cs+-assisted chemo selective reaction protocol for synthesizing 2-styryl quinoline biorelevant molecules
  31. Structural, physical, and radiation absorption properties of a significant nuclear power plant component: A comparison between REX-734 and 316L SS austenitic stainless steels
  32. Effect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis model
  33. Investigating the impact of CO2 emissions on the COVID-19 pandemic by generalized linear mixed model approach with inverse Gaussian and gamma distributions
  34. Influence of WO3 content on gamma rays attenuation characteristics of phosphate glasses at low energy range
  35. Study on CO2 absorption performance of ternary DES formed based on DEA as promoting factor
  36. Performance analyses of detonation engine cogeneration cycles
  37. Sterols from Centaurea pumilio L. with cell proliferative activity: In vitro and in silico studies
  38. Untargeted metabolomics revealing changes in aroma substances in flue-cured tobacco
  39. Effect of pumpkin enriched with calcium lactate on iron status in an animal model of postmenopausal osteoporosis
  40. Energy consumption, mechanical and metallographic properties of cryogenically treated tool steels
  41. Optimization of ultra-high pressure-assisted extraction of total phenols from Eucommia ulmoides leaves by response surface methodology
  42. Harpin enhances antioxidant nutrient accumulation and decreases enzymatic browning in stored soybean sprouts
  43. Physicochemical and biological properties of carvacrol
  44. Radix puerariae in the treatment of diabetic nephropathy: A network pharmacology analysis and experimental validation
  45. Anti-Alzheimer, antioxidants, glucose-6-phosphate dehydrogenase effects of Taverniera glabra mediated ZnO and Fe2O3 nanoparticles in alloxan-induced diabetic rats
  46. Experimental study on photocatalytic CO2 reduction performance of ZnS/CdS-TiO2 nanotube array thin films
  47. Epoxy-reinforced heavy metal oxides for gamma ray shielding purposes
  48. Black mulberry (Morus nigra L.) fruits: As a medicinal plant rich in human health-promoting compounds
  49. Promising antioxidant and antimicrobial effects of essential oils extracted from fruits of Juniperus thurifera: In vitro and in silico investigations
  50. Chloramine-T-induced oxidation of Rizatriptan Benzoate: An integral chemical and spectroscopic study of products, mechanisms and kinetics
  51. Study on antioxidant and antimicrobial potential of chemically profiled essential oils extracted from Juniperus phoenicea (L.) by use of in vitro and in silico approaches
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  53. Mineral composition, principal polyphenolic components, and evaluation of the anti-inflammatory, analgesic, and antioxidant properties of Cytisus villosus Pourr leaf extracts
  54. In vitro antiproliferative efficacy of Annona muricata seed and fruit extracts on several cancer cell lines
  55. An experimental study for chemical characterization of artificial anterior cruciate ligament with coated chitosan as biomaterial
  56. Prevalence of residual risks of the transfusion-transmitted infections in Riyadh hospitals: A two-year retrospective study
  57. Computational and experimental investigation of antibacterial and antifungal properties of Nicotiana tabacum extracts
  58. Reinforcement of cementitious mortars with hemp fibers and shives
  59. X-ray shielding properties of bismuth-borate glass doped with rare earth ions
  60. Green supported silver nanoparticles over modified reduced graphene oxide: Investigation of its antioxidant and anti-ovarian cancer effects
  61. Orthogonal synthesis of a versatile building block for dual functionalization of targeting vectors
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  67. Screening and optimization of extracellular pectinase produced by Bacillus thuringiensis SH7
  68. Determination of polyphenols in Chinese jujube using ultra-performance liquid chromatography–mass spectrometry
  69. Synergistic effects of harpin and NaCl in determining soybean sprout quality under non-sterile conditions
  70. Field evaluation of different eco-friendly alternative control methods against Panonychus citri [Acari: Tetranychidae] spider mite and its predators in citrus orchards
  71. Exploring the antimicrobial potential of biologically synthesized zero valent iron nanoparticles
  72. NaCl regulates goldfish growth and survival at three food supply levels under hypoxia
  73. An exploration of the physical, optical, mechanical, and radiation shielding properties of PbO–MgO–ZnO–B2O3 glasses
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  76. An alternative approach for the excess lifetime cancer risk and prediction of radiological parameters
  77. Panax ginseng leaf aqueous extract mediated green synthesis of AgNPs under ultrasound condition and investigation of its anti-lung adenocarcinoma effects
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  81. Antidiabetic, antioxidant and cytotoxicity activities of ortho- and para-substituted Schiff bases derived from metformin hydrochloride: Validation by molecular docking and in silico ADME studies
  82. Antioxidant, antidiabetic, antiglaucoma, and anticholinergic effects of Tayfi grape (Vitis vinifera): A phytochemical screening by LC-MS/MS analysis
  83. Identification of genetic polymorphisms in the stearoyl CoA desaturase gene and its association with milk quality traits in Najdi sheep
  84. Cold-acclimation effect on cadmium absorption and biosynthesis of polyphenolics, and free proline and photosynthetic pigments in Spirogyra aequinoctialis
  85. Analysis of secondary metabolites in Xinjiang Morus nigra leaves using different extraction methods with UPLC-Q/TOF-MS/MS technology
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  94. Twofold interpenetrated 3D Cd(ii) complex: Crystal structure and luminescent property
  95. Study on the microstructure and soil quality variation of composite soil with soft rock and sand
  96. Ancient spring waters still emerging and accessible in the Roman Forum area: Chemical–physical and microbiological characterization
  97. Extraction and characterization of type I collagen from scales of Mexican Biajaiba fish
  98. Finding small molecular compounds to decrease trimethylamine oxide levels in atherosclerosis by virtual screening
  99. Prefatory in silico studies and in vitro insecticidal effect of Nigella sativa (L.) essential oil and its active compound (carvacrol) against the Callosobruchus maculatus adults (Fab), a major pest of chickpea
  100. Polymerized methyl imidazole silver bromide (CH3C6H5AgBr)6: Synthesis, crystal structures, and catalytic activity
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  102. Influence of the addition of WO3 on TeO2–Na2O glass systems in view of the feature of mechanical, optical, and photon attenuation
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  104. GC-MS profile of extracts of an endophytic fungus Alternaria and evaluation of its anticancer and antibacterial potentialities
  105. Green synthesis, chemical characterization, and antioxidant and anti-colorectal cancer effects of vanadium nanoparticles
  106. Determination of caffeine content in coffee drinks prepared in some coffee shops in the local market in Jeddah City, Saudi Arabia
  107. A new 3D supramolecular Cu(ii) framework: Crystal structure and photocatalytic characteristics
  108. Bordeaux mixture accelerates ripening, delays senescence, and promotes metabolite accumulation in jujube fruit
  109. Important application value of injectable hydrogels loaded with omeprazole Schiff base complex in the treatment of pancreatitis
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  112. Metal gel particles loaded with epidermal cell growth factor promote skin wound repair mechanism by regulating miRNA
  113. In vitro exploration of Hypsizygus ulmarius (Bull.) mushroom fruiting bodies: Potential antidiabetic and anti-inflammatory agent
  114. Alteration in the molecular structure of the adenine base exposed to gamma irradiation: An ESR study
  115. Comprehensive study of optical, thermal, and gamma-ray shielding properties of Bi2O3–ZnO–PbO–B2O3 glasses
  116. Lewis acids as co-catalysts in Pd-based catalyzed systems of the octene-1 hydroethoxycarbonylation reaction
  117. Synthesis, Hirshfeld surface analysis, thermal, and selective α-glucosidase inhibitory studies of Schiff base transition metal complexes
  118. Protective properties of AgNPs green-synthesized by Abelmoschus esculentus on retinal damage on the virtue of its anti-inflammatory and antioxidant effects in diabetic rat
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  120. Treatment of gastric cancer by green mediated silver nanoparticles using Pistacia atlantica bark aqueous extract
  121. Preparation of newly developed porcelain ceramics containing WO3 nanoparticles for radiation shielding applications
  122. Utilization of computational methods for the identification of new natural inhibitors of human neutrophil elastase in inflammation therapy
  123. Some anticancer agents as effective glutathione S-transferase (GST) inhibitors
  124. Clay-based bricks’ rich illite mineral for gamma-ray shielding applications: An experimental evaluation of the effect of pressure rates on gamma-ray attenuation parameters
  125. Stability kinetics of orevactaene pigments produced by Epicoccum nigrum in solid-state fermentation
  126. Treatment of denture stomatitis using iron nanoparticles green-synthesized by Silybum marianum extract
  127. Characterization and antioxidant potential of white mustard (Brassica hirta) leaf extract and stabilization of sunflower oil
  128. Characteristics of Langmuir monomolecular monolayers formed by the novel oil blends
  129. Strategies for optimizing the single GdSrFeO4 phase synthesis
  130. Oleic acid and linoleic acid nanosomes boost immunity and provoke cell death via the upregulation of beta-defensin-4 at genetic and epigenetic levels
  131. Unraveling the therapeutic potential of Bombax ceiba roots: A comprehensive study of chemical composition, heavy metal content, antibacterial activity, and in silico analysis
  132. Green synthesis of AgNPs using plant extract and investigation of its anti-human colorectal cancer application
  133. The adsorption of naproxen on adsorbents obtained from pepper stalk extract by green synthesis
  134. Treatment of gastric cancer by silver nanoparticles encapsulated by chitosan polymers mediated by Pistacia atlantica extract under ultrasound condition
  135. In vitro protective and anti-inflammatory effects of Capparis spinosa and its flavonoids profile
  136. Wear and corrosion behavior of TiC and WC coatings deposited on high-speed steels by electro-spark deposition
  137. Therapeutic effects of green-formulated gold nanoparticles by Origanum majorana on spinal cord injury in rats
  138. Melanin antibacterial activity of two new strains, SN1 and SN2, of Exophiala phaeomuriformis against five human pathogens
  139. Evaluation of the analgesic and anesthetic properties of silver nanoparticles supported over biodegradable acacia gum-modified magnetic nanoparticles
  140. Review Articles
  141. Role and mechanism of fruit waste polyphenols in diabetes management
  142. A comprehensive review of non-alkaloidal metabolites from the subfamily Amaryllidoideae (Amaryllidaceae)
  143. Discovery of the chemical constituents, structural characteristics, and pharmacological functions of Chinese caterpillar fungus
  144. Eco-friendly green approach of nickel oxide nanoparticles for biomedical applications
  145. Advances in the pharmaceutical research of curcumin for oral administration
  146. Rapid Communication
  147. Determination of the contents of bioactive compounds in St. John’s wort (Hypericum perforatum): Comparison of commercial and wild samples
  148. Retraction
  149. Retraction of “Two mixed-ligand coordination polymers based on 2,5-thiophenedicarboxylic acid and flexible N-donor ligands: The protective effect on periodontitis via reducing the release of IL-1β and TNF-α”
  150. Topical Issue on Phytochemicals, biological and toxicological analysis of aromatic medicinal plants
  151. Anti-plasmodial potential of selected medicinal plants and a compound Atropine isolated from Eucalyptus obliqua
  152. Anthocyanin extract from black rice attenuates chronic inflammation in DSS-induced colitis mouse model by modulating the gut microbiota
  153. Evaluation of antibiofilm and cytotoxicity effect of Rumex vesicarius methanol extract
  154. Chemical compositions of Litsea umbellata and inhibition activities
  155. Green synthesis, characterization of silver nanoparticles using Rhynchosia capitata leaf extract and their biological activities
  156. GC-MS analysis and antibacterial activities of some plants belonging to the genus Euphorbia on selected bacterial isolates
  157. The abrogative effect of propolis on acrylamide-induced toxicity in male albino rats: Histological study
  158. A phytoconstituent 6-aminoflavone ameliorates lipopolysaccharide-induced oxidative stress mediated synapse and memory dysfunction via p-Akt/NF-kB pathway in albino mice
  159. Anti-diabetic potentials of Sorbaria tomentosa Lindl. Rehder: Phytochemistry (GC-MS analysis), α-amylase, α-glucosidase inhibitory, in vivo hypoglycemic, and biochemical analysis
  160. Assessment of cytotoxic and apoptotic activities of the Cassia angustifolia aqueous extract against SW480 colon cancer
  161. Biochemical analysis, antioxidant, and antibacterial efficacy of the bee propolis extract (Hymenoptera: Apis mellifera) against Staphylococcus aureus-induced infection in BALB/c mice: In vitro and in vivo study
  162. Assessment of essential elements and heavy metals in Saudi Arabian rice samples underwent various processing methods
  163. Two new compounds from leaves of Capparis dongvanensis (Sy, B. H. Quang & D. V. Hai) and inhibition activities
  164. Hydroxyquinoline sulfanilamide ameliorates STZ-induced hyperglycemia-mediated amyleoid beta burden and memory impairment in adult mice
  165. An automated reading of semi-quantitative hemagglutination results in microplates: Micro-assay for plant lectins
  166. Inductively coupled plasma mass spectrometry assessment of essential and toxic trace elements in traditional spices consumed by the population of the Middle Eastern region in their recipes
  167. Phytochemical analysis and anticancer activity of the Pithecellobium dulce seed extract in colorectal cancer cells
  168. Impact of climatic disturbances on the chemical compositions and metabolites of Salvia officinalis
  169. Physicochemical characterization, antioxidant and antifungal activities of essential oils of Urginea maritima and Allium sativum
  170. Phytochemical analysis and antifungal efficiency of Origanum majorana extracts against some phytopathogenic fungi causing tomato damping-off diseases
  171. Special Issue on 4th IC3PE
  172. Graphene quantum dots: A comprehensive overview
  173. Studies on the intercalation of calcium–aluminium layered double hydroxide-MCPA and its controlled release mechanism as a potential green herbicide
  174. Synergetic effect of adsorption and photocatalysis by zinc ferrite-anchored graphitic carbon nitride nanosheet for the removal of ciprofloxacin under visible light irradiation
  175. Exploring anticancer activity of the Indonesian guava leaf (Psidium guajava L.) fraction on various human cancer cell lines in an in vitro cell-based approach
  176. The comparison of gold extraction methods from the rock using thiourea and thiosulfate
  177. Special Issue on Marine environmental sciences and significance of the multidisciplinary approaches
  178. Sorption of alkylphenols and estrogens on microplastics in marine conditions
  179. Cytotoxic ketosteroids from the Red Sea soft coral Dendronephthya sp.
  180. Antibacterial and biofilm prevention metabolites from Acanthophora spicifera
  181. Characteristics, source, and health risk assessment of aerosol polyaromatic hydrocarbons in the rural and urban regions of western Saudi Arabia
  182. Special Issue on Advanced Nanomaterials for Energy, Environmental and Biological Applications - Part II
  183. Green synthesis, characterization, and evaluation of antibacterial activities of cobalt nanoparticles produced by marine fungal species Periconia prolifica
  184. Combustion-mediated sol–gel preparation of cobalt-doped ZnO nanohybrids for the degradation of acid red and antibacterial performance
  185. Perinatal supplementation with selenium nanoparticles modified with ascorbic acid improves hepatotoxicity in rat gestational diabetes
  186. Evaluation and chemical characterization of bioactive secondary metabolites from endophytic fungi associated with the ethnomedicinal plant Bergenia ciliata
  187. Enhancing photovoltaic efficiency with SQI-Br and SQI-I sensitizers: A comparative analysis
  188. Nanostructured p-PbS/p-CuO sulfide/oxide bilayer heterojunction as a promising photoelectrode for hydrogen gas generation
https://doi.org/10.1515/chem-2023-0139
Keywords for this article
marine fungi; Periconia prolifica; CoNPs; characterization; antibacterial activity
Creative Commons
BY 4.0

Articles in the same Issue

  1. Characteristics, source, and health risk assessment of aerosol polyaromatic hydrocarbons in the rural and urban regions of western Saudi Arabia
  2. Regular Articles
  3. A network-based correlation research between element electronegativity and node importance
  4. Pomegranate attenuates kidney injury in cyclosporine-induced nephrotoxicity in rats by suppressing oxidative stress
  5. Ab initio study of fundamental properties of XInO3 (X = K, Rb, Cs) perovskites
  6. Responses of feldspathic sandstone and sand-reconstituted soil C and N to freeze–thaw cycles
  7. Robust fractional control based on high gain observers design (RNFC) for a Spirulina maxima culture interfaced with an advanced oxidation process
  8. Study on arsenic speciation and redistribution mechanism in Lonicera japonica plants via synchrotron techniques
  9. Optimization of machining Nilo 36 superalloy parameters in turning operation
  10. Vacuum impregnation pre-treatment: A novel method for incorporating mono- and divalent cations into potato strips to reduce the acrylamide formation in French fries
  11. Characterization of effective constituents in Acanthopanax senticosus fruit for blood deficiency syndrome based on the chinmedomics strategy
  12. Comparative analysis of the metabolites in Pinellia ternata from two producing regions using ultra-high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry
  13. The assessment of environmental parameter along the desalination plants in the Kingdom of Saudi Arabia
  14. Effects of harpin and carbendazim on antioxidant accumulation in young jujube leaves
  15. The effects of in ovo injected with sodium borate on hatching performance and small intestine morphology in broiler chicks
  16. Optimization of cutting forces and surface roughness via ANOVA and grey relational analysis in machining of In718
  17. Essential oils of Origanum compactum Benth: Chemical characterization, in vitro, in silico, antioxidant, and antibacterial activities
  18. Translocation of tungsten(vi) oxide/gadolinium(iii) fluoride in tellurite glasses towards improvement of gamma-ray attenuation features in high-density glass shields
  19. Mechanical properties, elastic moduli, and gamma ray attenuation competencies of some TeO2–WO3–GdF3 glasses: Tailoring WO3–GdF3 substitution toward optimum behavioral state range
  20. Comparison between the CIDR or sponge with hormone injection to induce estrus synchronization for twining and sex preselection in Naimi sheep
  21. Exergetic performance analyses of three different cogeneration plants
  22. Psoralea corylifolia (babchi) seeds enhance proliferation of normal human cultured melanocytes: GC–MS profiling and biological investigation
  23. A novel electrochemical micro-titration method for quantitative evaluation of the DPPH free radical scavenging capacity of caffeic acid
  24. Comparative study between supported bimetallic catalysts for nitrate remediation in water
  25. Persicaline, an alkaloid from Salvadora persica, inhibits proliferation and induces apoptosis and cell-cycle arrest in MCF-7 cells
  26. Determination of nicotine content in locally produced smokeless tobacco (Shammah) samples from Jazan region of Saudi Arabia using a convenient HPLC-MS/MS method
  27. Changes in oxidative stress markers in pediatric burn injury over a 1-week period
  28. Integrated geophysical techniques applied for petroleum basins structural characterization in the central part of the Western Desert, Egypt
  29. The impact of chemical modifications on gamma-ray attenuation properties of some WO3-reinforced tellurite glasses
  30. Microwave and Cs+-assisted chemo selective reaction protocol for synthesizing 2-styryl quinoline biorelevant molecules
  31. Structural, physical, and radiation absorption properties of a significant nuclear power plant component: A comparison between REX-734 and 316L SS austenitic stainless steels
  32. Effect of Moringa oleifera on serum YKL-40 level: In vivo rat periodontitis model
  33. Investigating the impact of CO2 emissions on the COVID-19 pandemic by generalized linear mixed model approach with inverse Gaussian and gamma distributions
  34. Influence of WO3 content on gamma rays attenuation characteristics of phosphate glasses at low energy range
  35. Study on CO2 absorption performance of ternary DES formed based on DEA as promoting factor
  36. Performance analyses of detonation engine cogeneration cycles
  37. Sterols from Centaurea pumilio L. with cell proliferative activity: In vitro and in silico studies
  38. Untargeted metabolomics revealing changes in aroma substances in flue-cured tobacco
  39. Effect of pumpkin enriched with calcium lactate on iron status in an animal model of postmenopausal osteoporosis
  40. Energy consumption, mechanical and metallographic properties of cryogenically treated tool steels
  41. Optimization of ultra-high pressure-assisted extraction of total phenols from Eucommia ulmoides leaves by response surface methodology
  42. Harpin enhances antioxidant nutrient accumulation and decreases enzymatic browning in stored soybean sprouts
  43. Physicochemical and biological properties of carvacrol
  44. Radix puerariae in the treatment of diabetic nephropathy: A network pharmacology analysis and experimental validation
  45. Anti-Alzheimer, antioxidants, glucose-6-phosphate dehydrogenase effects of Taverniera glabra mediated ZnO and Fe2O3 nanoparticles in alloxan-induced diabetic rats
  46. Experimental study on photocatalytic CO2 reduction performance of ZnS/CdS-TiO2 nanotube array thin films
  47. Epoxy-reinforced heavy metal oxides for gamma ray shielding purposes
  48. Black mulberry (Morus nigra L.) fruits: As a medicinal plant rich in human health-promoting compounds
  49. Promising antioxidant and antimicrobial effects of essential oils extracted from fruits of Juniperus thurifera: In vitro and in silico investigations
  50. Chloramine-T-induced oxidation of Rizatriptan Benzoate: An integral chemical and spectroscopic study of products, mechanisms and kinetics
  51. Study on antioxidant and antimicrobial potential of chemically profiled essential oils extracted from Juniperus phoenicea (L.) by use of in vitro and in silico approaches
  52. Screening and characterization of fungal taxol-producing endophytic fungi for evaluation of antimicrobial and anticancer activities
  53. Mineral composition, principal polyphenolic components, and evaluation of the anti-inflammatory, analgesic, and antioxidant properties of Cytisus villosus Pourr leaf extracts
  54. In vitro antiproliferative efficacy of Annona muricata seed and fruit extracts on several cancer cell lines
  55. An experimental study for chemical characterization of artificial anterior cruciate ligament with coated chitosan as biomaterial
  56. Prevalence of residual risks of the transfusion-transmitted infections in Riyadh hospitals: A two-year retrospective study
  57. Computational and experimental investigation of antibacterial and antifungal properties of Nicotiana tabacum extracts
  58. Reinforcement of cementitious mortars with hemp fibers and shives
  59. X-ray shielding properties of bismuth-borate glass doped with rare earth ions
  60. Green supported silver nanoparticles over modified reduced graphene oxide: Investigation of its antioxidant and anti-ovarian cancer effects
  61. Orthogonal synthesis of a versatile building block for dual functionalization of targeting vectors
  62. Thymbra spicata leaf extract driven biogenic synthesis of Au/Fe3O4 nanocomposite and its bio-application in the treatment of different types of leukemia
  63. The role of Ag2O incorporation in nuclear radiation shielding behaviors of the Li2O–Pb3O4–SiO2 glass system: A multi-step characterization study
  64. A stimuli-responsive in situ spray hydrogel co-loaded with naringenin and gentamicin for chronic wounds
  65. Assessment of the impact of γ-irradiation on the piperine content and microbial quality of black pepper
  66. Antioxidant, sensory, and functional properties of low-alcoholic IPA beer with Pinus sylvestris L. shoots addition fermented using unconventional yeast
  67. Screening and optimization of extracellular pectinase produced by Bacillus thuringiensis SH7
  68. Determination of polyphenols in Chinese jujube using ultra-performance liquid chromatography–mass spectrometry
  69. Synergistic effects of harpin and NaCl in determining soybean sprout quality under non-sterile conditions
  70. Field evaluation of different eco-friendly alternative control methods against Panonychus citri [Acari: Tetranychidae] spider mite and its predators in citrus orchards
  71. Exploring the antimicrobial potential of biologically synthesized zero valent iron nanoparticles
  72. NaCl regulates goldfish growth and survival at three food supply levels under hypoxia
  73. An exploration of the physical, optical, mechanical, and radiation shielding properties of PbO–MgO–ZnO–B2O3 glasses
  74. A novel statistical modeling of air pollution and the COVID-19 pandemic mortality data by Poisson, geometric, and negative binomial regression models with fixed and random effects
  75. Treatment activity of the injectable hydrogels loaded with dexamethasone In(iii) complex on glioma by inhibiting the VEGF signaling pathway
  76. An alternative approach for the excess lifetime cancer risk and prediction of radiological parameters
  77. Panax ginseng leaf aqueous extract mediated green synthesis of AgNPs under ultrasound condition and investigation of its anti-lung adenocarcinoma effects
  78. Study of hydrolysis and production of instant ginger (Zingiber officinale) tea
  79. Novel green synthesis of zinc oxide nanoparticles using Salvia rosmarinus extract for treatment of human lung cancer
  80. Evaluation of second trimester plasma lipoxin A4, VEGFR-1, IL-6, and TNF-α levels in pregnant women with gestational diabetes mellitus
  81. Antidiabetic, antioxidant and cytotoxicity activities of ortho- and para-substituted Schiff bases derived from metformin hydrochloride: Validation by molecular docking and in silico ADME studies
  82. Antioxidant, antidiabetic, antiglaucoma, and anticholinergic effects of Tayfi grape (Vitis vinifera): A phytochemical screening by LC-MS/MS analysis
  83. Identification of genetic polymorphisms in the stearoyl CoA desaturase gene and its association with milk quality traits in Najdi sheep
  84. Cold-acclimation effect on cadmium absorption and biosynthesis of polyphenolics, and free proline and photosynthetic pigments in Spirogyra aequinoctialis
  85. Analysis of secondary metabolites in Xinjiang Morus nigra leaves using different extraction methods with UPLC-Q/TOF-MS/MS technology
  86. Nanoarchitectonics and performance evaluation of a Fe3O4-stabilized Pickering emulsion-type differential pressure plugging agent
  87. Investigating pyrolysis characteristics of Shengdong coal through Py-GC/MS
  88. Extraction, phytochemical characterization, and antifungal activity of Salvia rosmarinus extract
  89. Introducing a novel and natural antibiotic for the treatment of oral pathogens: Abelmoschus esculentus green-formulated silver nanoparticles
  90. Optimization of gallic acid-enriched ultrasonic-assisted extraction from mango peels
  91. Effect of gamma rays irradiation in the structure, optical, and electrical properties of samarium doped bismuth titanate ceramics
  92. Combinatory in silico investigation for potential inhibitors from Curcuma sahuynhensis Škorničk. & N.S. Lý volatile phytoconstituents against influenza A hemagglutinin, SARS-CoV-2 main protease, and Omicron-variant spike protein
  93. Physical, mechanical, and gamma ray shielding properties of the Bi2O3–BaO–B2O3–ZnO–As2O3–MgO–Na2O glass system
  94. Twofold interpenetrated 3D Cd(ii) complex: Crystal structure and luminescent property
  95. Study on the microstructure and soil quality variation of composite soil with soft rock and sand
  96. Ancient spring waters still emerging and accessible in the Roman Forum area: Chemical–physical and microbiological characterization
  97. Extraction and characterization of type I collagen from scales of Mexican Biajaiba fish
  98. Finding small molecular compounds to decrease trimethylamine oxide levels in atherosclerosis by virtual screening
  99. Prefatory in silico studies and in vitro insecticidal effect of Nigella sativa (L.) essential oil and its active compound (carvacrol) against the Callosobruchus maculatus adults (Fab), a major pest of chickpea
  100. Polymerized methyl imidazole silver bromide (CH3C6H5AgBr)6: Synthesis, crystal structures, and catalytic activity
  101. Using calcined waste fish bones as a green solid catalyst for biodiesel production from date seed oil
  102. Influence of the addition of WO3 on TeO2–Na2O glass systems in view of the feature of mechanical, optical, and photon attenuation
  103. Naringin ameliorates 5-fluorouracil elicited neurotoxicity by curtailing oxidative stress and iNOS/NF-ĸB/caspase-3 pathway
  104. GC-MS profile of extracts of an endophytic fungus Alternaria and evaluation of its anticancer and antibacterial potentialities
  105. Green synthesis, chemical characterization, and antioxidant and anti-colorectal cancer effects of vanadium nanoparticles
  106. Determination of caffeine content in coffee drinks prepared in some coffee shops in the local market in Jeddah City, Saudi Arabia
  107. A new 3D supramolecular Cu(ii) framework: Crystal structure and photocatalytic characteristics
  108. Bordeaux mixture accelerates ripening, delays senescence, and promotes metabolite accumulation in jujube fruit
  109. Important application value of injectable hydrogels loaded with omeprazole Schiff base complex in the treatment of pancreatitis
  110. Color tunable benzothiadiazole-based small molecules for lightening applications
  111. Investigation of structural, dielectric, impedance, and mechanical properties of hydroxyapatite-modified barium titanate composites for biomedical applications
  112. Metal gel particles loaded with epidermal cell growth factor promote skin wound repair mechanism by regulating miRNA
  113. In vitro exploration of Hypsizygus ulmarius (Bull.) mushroom fruiting bodies: Potential antidiabetic and anti-inflammatory agent
  114. Alteration in the molecular structure of the adenine base exposed to gamma irradiation: An ESR study
  115. Comprehensive study of optical, thermal, and gamma-ray shielding properties of Bi2O3–ZnO–PbO–B2O3 glasses
  116. Lewis acids as co-catalysts in Pd-based catalyzed systems of the octene-1 hydroethoxycarbonylation reaction
  117. Synthesis, Hirshfeld surface analysis, thermal, and selective α-glucosidase inhibitory studies of Schiff base transition metal complexes
  118. Protective properties of AgNPs green-synthesized by Abelmoschus esculentus on retinal damage on the virtue of its anti-inflammatory and antioxidant effects in diabetic rat
  119. Effects of green decorated AgNPs on lignin-modified magnetic nanoparticles mediated by Cydonia on cecal ligation and puncture-induced sepsis
  120. Treatment of gastric cancer by green mediated silver nanoparticles using Pistacia atlantica bark aqueous extract
  121. Preparation of newly developed porcelain ceramics containing WO3 nanoparticles for radiation shielding applications
  122. Utilization of computational methods for the identification of new natural inhibitors of human neutrophil elastase in inflammation therapy
  123. Some anticancer agents as effective glutathione S-transferase (GST) inhibitors
  124. Clay-based bricks’ rich illite mineral for gamma-ray shielding applications: An experimental evaluation of the effect of pressure rates on gamma-ray attenuation parameters
  125. Stability kinetics of orevactaene pigments produced by Epicoccum nigrum in solid-state fermentation
  126. Treatment of denture stomatitis using iron nanoparticles green-synthesized by Silybum marianum extract
  127. Characterization and antioxidant potential of white mustard (Brassica hirta) leaf extract and stabilization of sunflower oil
  128. Characteristics of Langmuir monomolecular monolayers formed by the novel oil blends
  129. Strategies for optimizing the single GdSrFeO4 phase synthesis
  130. Oleic acid and linoleic acid nanosomes boost immunity and provoke cell death via the upregulation of beta-defensin-4 at genetic and epigenetic levels
  131. Unraveling the therapeutic potential of Bombax ceiba roots: A comprehensive study of chemical composition, heavy metal content, antibacterial activity, and in silico analysis
  132. Green synthesis of AgNPs using plant extract and investigation of its anti-human colorectal cancer application
  133. The adsorption of naproxen on adsorbents obtained from pepper stalk extract by green synthesis
  134. Treatment of gastric cancer by silver nanoparticles encapsulated by chitosan polymers mediated by Pistacia atlantica extract under ultrasound condition
  135. In vitro protective and anti-inflammatory effects of Capparis spinosa and its flavonoids profile
  136. Wear and corrosion behavior of TiC and WC coatings deposited on high-speed steels by electro-spark deposition
  137. Therapeutic effects of green-formulated gold nanoparticles by Origanum majorana on spinal cord injury in rats
  138. Melanin antibacterial activity of two new strains, SN1 and SN2, of Exophiala phaeomuriformis against five human pathogens
  139. Evaluation of the analgesic and anesthetic properties of silver nanoparticles supported over biodegradable acacia gum-modified magnetic nanoparticles
  140. Review Articles
  141. Role and mechanism of fruit waste polyphenols in diabetes management
  142. A comprehensive review of non-alkaloidal metabolites from the subfamily Amaryllidoideae (Amaryllidaceae)
  143. Discovery of the chemical constituents, structural characteristics, and pharmacological functions of Chinese caterpillar fungus
  144. Eco-friendly green approach of nickel oxide nanoparticles for biomedical applications
  145. Advances in the pharmaceutical research of curcumin for oral administration
  146. Rapid Communication
  147. Determination of the contents of bioactive compounds in St. John’s wort (Hypericum perforatum): Comparison of commercial and wild samples
  148. Retraction
  149. Retraction of “Two mixed-ligand coordination polymers based on 2,5-thiophenedicarboxylic acid and flexible N-donor ligands: The protective effect on periodontitis via reducing the release of IL-1β and TNF-α”
  150. Topical Issue on Phytochemicals, biological and toxicological analysis of aromatic medicinal plants
  151. Anti-plasmodial potential of selected medicinal plants and a compound Atropine isolated from Eucalyptus obliqua
  152. Anthocyanin extract from black rice attenuates chronic inflammation in DSS-induced colitis mouse model by modulating the gut microbiota
  153. Evaluation of antibiofilm and cytotoxicity effect of Rumex vesicarius methanol extract
  154. Chemical compositions of Litsea umbellata and inhibition activities
  155. Green synthesis, characterization of silver nanoparticles using Rhynchosia capitata leaf extract and their biological activities
  156. GC-MS analysis and antibacterial activities of some plants belonging to the genus Euphorbia on selected bacterial isolates
  157. The abrogative effect of propolis on acrylamide-induced toxicity in male albino rats: Histological study
  158. A phytoconstituent 6-aminoflavone ameliorates lipopolysaccharide-induced oxidative stress mediated synapse and memory dysfunction via p-Akt/NF-kB pathway in albino mice
  159. Anti-diabetic potentials of Sorbaria tomentosa Lindl. Rehder: Phytochemistry (GC-MS analysis), α-amylase, α-glucosidase inhibitory, in vivo hypoglycemic, and biochemical analysis
  160. Assessment of cytotoxic and apoptotic activities of the Cassia angustifolia aqueous extract against SW480 colon cancer
  161. Biochemical analysis, antioxidant, and antibacterial efficacy of the bee propolis extract (Hymenoptera: Apis mellifera) against Staphylococcus aureus-induced infection in BALB/c mice: In vitro and in vivo study
  162. Assessment of essential elements and heavy metals in Saudi Arabian rice samples underwent various processing methods
  163. Two new compounds from leaves of Capparis dongvanensis (Sy, B. H. Quang & D. V. Hai) and inhibition activities
  164. Hydroxyquinoline sulfanilamide ameliorates STZ-induced hyperglycemia-mediated amyleoid beta burden and memory impairment in adult mice
  165. An automated reading of semi-quantitative hemagglutination results in microplates: Micro-assay for plant lectins
  166. Inductively coupled plasma mass spectrometry assessment of essential and toxic trace elements in traditional spices consumed by the population of the Middle Eastern region in their recipes
  167. Phytochemical analysis and anticancer activity of the Pithecellobium dulce seed extract in colorectal cancer cells
  168. Impact of climatic disturbances on the chemical compositions and metabolites of Salvia officinalis
  169. Physicochemical characterization, antioxidant and antifungal activities of essential oils of Urginea maritima and Allium sativum
  170. Phytochemical analysis and antifungal efficiency of Origanum majorana extracts against some phytopathogenic fungi causing tomato damping-off diseases
  171. Special Issue on 4th IC3PE
  172. Graphene quantum dots: A comprehensive overview
  173. Studies on the intercalation of calcium–aluminium layered double hydroxide-MCPA and its controlled release mechanism as a potential green herbicide
  174. Synergetic effect of adsorption and photocatalysis by zinc ferrite-anchored graphitic carbon nitride nanosheet for the removal of ciprofloxacin under visible light irradiation
  175. Exploring anticancer activity of the Indonesian guava leaf (Psidium guajava L.) fraction on various human cancer cell lines in an in vitro cell-based approach
  176. The comparison of gold extraction methods from the rock using thiourea and thiosulfate
  177. Special Issue on Marine environmental sciences and significance of the multidisciplinary approaches
  178. Sorption of alkylphenols and estrogens on microplastics in marine conditions
  179. Cytotoxic ketosteroids from the Red Sea soft coral Dendronephthya sp.
  180. Antibacterial and biofilm prevention metabolites from Acanthophora spicifera
  181. Characteristics, source, and health risk assessment of aerosol polyaromatic hydrocarbons in the rural and urban regions of western Saudi Arabia
  182. Special Issue on Advanced Nanomaterials for Energy, Environmental and Biological Applications - Part II
  183. Green synthesis, characterization, and evaluation of antibacterial activities of cobalt nanoparticles produced by marine fungal species Periconia prolifica
  184. Combustion-mediated sol–gel preparation of cobalt-doped ZnO nanohybrids for the degradation of acid red and antibacterial performance
  185. Perinatal supplementation with selenium nanoparticles modified with ascorbic acid improves hepatotoxicity in rat gestational diabetes
  186. Evaluation and chemical characterization of bioactive secondary metabolites from endophytic fungi associated with the ethnomedicinal plant Bergenia ciliata
  187. Enhancing photovoltaic efficiency with SQI-Br and SQI-I sensitizers: A comparative analysis
  188. Nanostructured p-PbS/p-CuO sulfide/oxide bilayer heterojunction as a promising photoelectrode for hydrogen gas generation
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