Home Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
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Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials

  • Juping Zhang , Qian Kong , Jibo Zhang and Jun Guo EMAIL logo
Published/Copyright: September 4, 2024
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Open Medicine
From the journal Open Medicine Volume 19 Issue 1

Abstract

Background

Gastric cancer (GC) is a leading cause of cancer-related morbidity and mortality globally. This meta-analysis was conducted to assess the impact of nutritional interventions on clinical outcomes in GC patients.

Methods

Comprehensive search was conducted across four medical databases to identify randomized controlled trials (RCTs) that examined nutritional interventions in GC patients. The outcomes assessed included hospitalization duration, nutritional status, immune function, and complications.

Results

A total of 11 studies were included. Enteral nutrition (EN) significantly reduce hospital stay duration compared to no nutritional intervention (SMD = −1.22, 95% CI [−1.72, −0.73], P < 0.001) and parenteral nutrition (PN) (SMD = −1.30, 95% CI [−1.78, −0.82], P < 0.001), but showed no significant difference compared to immunonutrition (IN). EN also improved nutritional status, indicated by higher albumin prealbumin levels, and improved immune function by elevating CD4+ levels (SMD = 1.09, 95% CI [0.61, 1.57], P < 0.001). However, IN showed superior effects on immunoglobulin levels (IgG and IgM). No significant differences were observed in complication rates among EN, IN, and PN interventions.

Conclusion

Nutritional support, particularly EN and IN, can significantly improve hospitalization outcomes, nutritional status, and immune function. Customizing interventions according to patient requirements can optimize therapeutic outcomes, highlighting the need for further research in this area.

Keywords: gastric cancer; nutritional support; enteral nutrition; immunonutrition; parenteral nutrition; meta-analysis

1 Introduction

Gastric cancer (GC) presents a significant challenge in the field of oncology and is consistently ranked as one of the most commonly diagnosed malignancies worldwide. With approximately one million new cases reported each year, it is a major global health concern [1]. Its prominence is not merely due to its high incidence, but also its substantial contribution to cancer-related morbidity and mortality [2].

The complex pathophysiology of GC leads to a variety of symptoms, such as impaired oral intake, diminished nutrient absorption, and metabolic imbalances, all of which collectively predispose patients to malnutrition [3,4]. The effects of malnutrition in GC patients are far-reaching, influencing treatment outcomes, modulating therapy tolerance, and ultimately affecting survival rates [4].

Various factors contribute to the development of GC. Notably, Helicobacter pylori infection, specific dietary inclinations, smoking, and genetic markers emerge as predominant contributors [5]. However, the importance of nutrition in managing GC is often overlooked. As the disease progresses, patients experience a range of symptoms, from mild dysphagia and early satiety to more severe nausea and vomiting. These symptoms, combined with the catabolic nature of malignancies, often lead to significant weight loss, muscle wasting, and reduced physical function [6]. These nutritional challenges not only impact a patient’s quality of life but also pose significant barriers to effective therapeutic interventions [7].

Recognizing the profound implications of nutritional deficits, a wide spectrum of interventional strategies has been conceptualized over the years [8]. These range from dietary guidance and oral supplements to advanced methods like enteral nutrition (EN) and parenteral nutrition (PN) [8,9]. Recent evidence suggests that these nutritional interventions can improve treatment efficacy, decrease hospital stays and post-operative complications, and enhance overall quality of life [8]. Although some studies endorse the effects of these interventions, others express doubts, citing inconclusive or minimal effects [10–12]. These discrepancies indicate the urgent need for a thorough and critical evaluation of existing literature.

Motivated by this imperative, we undertook this meta-analysis. Our main goal is to scrupulously summarize evidence from randomized controlled trials (RCTs), focusing on the nexus between nutritional support and clinical outcomes in GC patients.

2 Methods

The meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The study protocol was registered online in the International Prospective Register Systematic Reviews (PROSPERO number: CRD42024558364).

2.1 Literature search

A comprehensive search was carried out across multiple medical databases, including PubMed, Embase, Cochrane, and Web of Science, to identify relevant RCTs published from the inception of each database to August 17, 2023. The search strategy utilized a combination of relevant Medical Subject Headings terms and keywords, such as “gastric cancer,” “nutritional support,” “randomized controlled trial” and their synonyms. The detailed search strategy is summarized in Table S1.

2.2 Study selection criteria

Studies were eligible if they met the following criteria: (1) RCT design; (2) participants diagnosed with GC; (3) intervention group received nutritional support while the control group underwent standard treatment without nutritional support; (4) reported relevant outcomes such as hospitalization duration, indicators related to nutritional status and immune function, and complications (including gastrointestinal adverse reactions, surgical site infections, anastomotic leakage, and pulmonary infections); and (5) article published in English and Chinese. For the purposes of this study, “immunonutrition” (IN) was defined as enteral feeding routes that include immunomodulating nutrients such as arginine, glutamine, omega-3 fatty acids, and nucleotides. Studies were excluded if they were non-RCT designs, duplicates, reviews, editorials, letters, guidelines, case reports/series, or lacked complete or necessary outcome reporting. Study selection was independently undertaken by two authors, and any discrepancies between these two authors were resolved by a third author.

2.3 Data extraction

Data extraction from the selected studies was independently performed by two authors, including the first author’s name, publication year, country, sample sizes, and intervention details. Risk of bias for RCTs was assessed using the Cochrane Risk of Bias tool.

2.4 Data analysis

Meta-analysis was performed using RevMan 5.3 software (Cochrane Collaboration, Oxford, UK). The data were presented as mean with standard deviation. Standard mean differences (SMD) with 95% confidence intervals (CI) were used to estimate the effect sizes for continuous variables, while the binomial variables were presented as risk ratio with 95% CI. Heterogeneity in the effect estimate was determined by the Chi-square test, and the inconsistency was quantified using the I 2 statistics. The choice between random effects (I 2 > 50%) or fixed-effects (I 2 ≤ 50%) model was based on the significance heterogeneity. The statistical significance of the pooled estimates was determined using Z-test, with a P value of <0.05 considered as statistically significant. Publication bias was assessed using funnel plots.

3 Results

3.1 Literature search and study characteristics

The literature search and study selection process are summarized in Figure 1. A total of 2,205 articles were retrieved – of which 787 were duplicates and 1,345 irrelevant studies were discarded. From 73 screened records, 62 were excluded (of which 9 were not found in full text). Finally, 11 studies including 1,597 GC patients were included for the meta-analysis [9,13–22]. The detailed study characteristics are retrieved in Table 1.

Figure 1 PRISMA flow diagram.
Figure 1

PRISMA flow diagram.

Table 1

Characteristics of included studies

First author, year Country Patient type TNM stage Concurrent therapy Intervention/control Sample size (intervention/control) Mean age (intervention/control) Time of intervention
Liu, 2011 China Surgical only IIb; III; IV None Gln: glutamine-enhanced EN 28/28/28 Gln: 71.5 ± 6.1 7 days after surgery
EN: conventional EN EN: 74.1 ± 9.3
PN: parenteral nutrition PN: 70.2 ± 8.1
Fujitani, 2012 Japan Surgical only T1–T4; N0–N3 None Intervention: immunonutrition 127/117 Intervention: 64 (26–78) 5 days before surgery
Control: regular diet Control: 65 (30–79)
Liu, 2012 China Surgical Only NR None EN + Gln: immune-enhanced EN (EN + Gln) 28/24/26 EN + Gln: 57.3 ± 7.1 Within 48 h after the surgery for 7 days
EN: standard EN EN: 58.4 ± 6.3
Control: standard nutritional support Control: 56.2 ± 6.7
Marano, 2013 Italy Surgical only T1–T4; N0–N3 None Intervention: enteral immunoenriched nutrition 54/55 Intervention: 66.6 (55–78) From 6 h after surgery until the seventh postoperative day
Control: standard EN Control: 65.1 (49–83)
Chen, 2014 China Surgical only I; II; III None Intervention: early EN 50/50 Intervention: 59.5 ± 6.6 7 days after surgery
Control: PN Control: 59.1 ± 5.9
Pu, 2014 China Surgical only NR None Intervention: early EN with long peptide mixture 35/35 Intervention: 60.5 ± 9.3 Within 24 h after the surgery for 6 days
Control: early EN with glucose saline Control: 61.3 ± 10.2
Li, 2015(1) China Surgical only NR None Intervention: early EN 200/200 Intervention: 60.8 ± 5.9 Postoperative for 7 days
Control: PN Control: 56.0 ± 7.6
Li, 2015(2) China Surgical only NR None Intervention: early EN 150/150 Intervention: 59.2 ± 9.7 From postoperative day 2 to postoperative day 7
Control: conventional perioperative treatment Control: 60.4 ± 9.2
Cui, 2017 China Surgical only NR Postoperative chemotherapy Intervention: ONS 13/10 Intervention: 58.2 ± 17.5 From first day after discharge from surgery and lasts for 90 days
Control: dietary guidance Control: 67.9 ± 8.5
Ida, 2017 Japan Surgical only Clinical T1–T4a and M0 disease Patients diagnosed with pathological stage II or III disease received adjuvant chemotherapy using S-1. Adjuvant therapy was initiated within 6 weeks after surgery and continued for 1 year Intervention: ONS (EPA + standard diet) 63/60 Intervention: 65.1 (31–79) 7 days before and 21 days after surgery
Control: Standard diet Control: 65.6 (30–80)
He, 2022 China Surgical only T2-4aN0-3M0 None Intervention: ONS 31/35 Intervention: 63.2 ± 12.0 From the first day after surgery to the fifth day
Control: dietary advice Control: 60.5 ± 9.4

Gln, glutamine; EN, enteral nutrition; PN: parenteral nutrition; EPA, eicosapentaenoic acid; ONS: oral nutritional supplement; NR: not reported.

3.2 Study quality assessment

The quality of included studies was assessed according to risk of bias (Figure 2). Among them, seven studies performed appropriate randomization procedures, and four studies reported no or unclear information about randomization procedures. Information on allocation concealment and blinding was unclear or has high risk in all studies, due to the nature of nutritional interventions, and the fact that subjects might be aware of their intervention. Besides, most studies provided adequate outcome data and adequate reporting of results because they reported the same results as described in Section 2.

Figure 2 Risk of bias assessment: (a) risk of bias graph and (b) risk of bias summary.
Figure 2

Risk of bias assessment: (a) risk of bias graph and (b) risk of bias summary.

3.3 Duration of hospital stay and time to first flatus

A total of six RCTs evaluated the effect of nutritional interventions on the length of hospitalization in GC patients, among which two studies comparing EN and no nutritional intervention, four studies comparing EN and IN, and two studies comparing EN and PN. As shown in Figure 3, the length of hospitalization was significantly shorter in GC patients who received EN compared with those who did not undergo nutritional intervention (SMD = −1.22, 95% CI [−1.72, −0.73], P < 0.001) or who received PN (SMD = −1.30, 95% CI [−1.78, −0.82], P < 0.001), while the benefits of EN in length of hospitalization was similar to IN (P > 0.05). In contrast, two RCTs investigated the influence of EN compared to no nutritional intervention on the time to first flatus in GC patients and a study reported the effect of oral nutritional supplement (ONS) compared to no nutritional intervention in GC patients. In both cases, there were no significant differences (P > 0.05). However, a study demonstrated that IN significantly reduced the time to first flatus compared to no nutritional intervention. In addition, four RCTs compared the effects of EN versus IN or PN on the time to first flatus. Patients receiving EN had a significantly shorter time to first flatus compared to those receiving PN (SMD = −2.14, 95% CI [−2.37, −1.91], P < 0.001). However, there was no significant difference compared to those receiving IN (P > 0.05) (Figure S1).

Figure 3 Forest plot comparing length of hospitalization in GC patients receiving EN versus those receiving IN, PN, or no nutritional intervention. GC, gastric cancer; EN, enteral nutrition; IN, immunonutrition; PN: parenteral nutrition; CI, confidence interval.
Figure 3

Forest plot comparing length of hospitalization in GC patients receiving EN versus those receiving IN, PN, or no nutritional intervention. GC, gastric cancer; EN, enteral nutrition; IN, immunonutrition; PN: parenteral nutrition; CI, confidence interval.

3.4 Incidence of complications

A pooled analysis of seven studies was conducted to evaluate whether different nutritional interventions impact complication rates in GC patients. As shown in Figure 4a, the total complication rates of IN, EN, and ONS interventions were similar to those of the control group (P > 0.05). In addition, there was no significant difference in total complication rates for EN compared with PN and IN (P > 0.05), suggesting that the risk to complication is not improved by all types of nutrition interventions (Figure 4b). Furthermore, analysis of specific complications, including gastrointestinal adverse reactions, surgical site infections, anastomotic leakage, and pulmonary infections, showed that these complication rates in patients with EN were similar to those with IN or PN (Figure S2).

Figure 4 Forest plot comparing complication rates in GC patients receiving different nutritional interventions: (a) IN, EN, or ONS versus control; (b) EN versus PN or IN. GC, gastric cancer; EN, enteral nutrition; IN, immunonutrition; PN: parenteral nutrition; ONS, oral nutritional supplement; CI, confidence interval.
Figure 4

Forest plot comparing complication rates in GC patients receiving different nutritional interventions: (a) IN, EN, or ONS versus control; (b) EN versus PN or IN. GC, gastric cancer; EN, enteral nutrition; IN, immunonutrition; PN: parenteral nutrition; ONS, oral nutritional supplement; CI, confidence interval.

3.5 Nutritional status

The role of nutritional intervention on the nutritional status of GC patients was further evaluated. Both albumin and prealbumin levels were significantly higher in patients who received EN compared to patients without nutritional intervention (albumin: SMD = 1.02, 95% CI [0.15, 1.89], P = 0.02; prealbumin: SMD = 1.13, 95% CI [0.90, 1.35], P < 0.001) or who received PN (albumin: SMD = 0.80, 95% CI [0.63, 0.98], P < 0.001; prealbumin: SMD = 1.10, 95% CI [0.56, 1.63], P < 0.001), but there was no significant difference compared to IN (P > 0.05) (Figure 5a and b).

Figure 5 Forest plot comparing nutritional status in GC patients receiving different nutritional interventions: (a) comparison of albumin levels in EN versus control, IN, or PN; (b) comparison of prealbumin levels in EN versus control, IN, or PN. GC, gastric cancer; EN, enteral nutrition; IN, immunonutrition; PN: parenteral nutrition; CI, confidence interval.
Figure 5

Forest plot comparing nutritional status in GC patients receiving different nutritional interventions: (a) comparison of albumin levels in EN versus control, IN, or PN; (b) comparison of prealbumin levels in EN versus control, IN, or PN. GC, gastric cancer; EN, enteral nutrition; IN, immunonutrition; PN: parenteral nutrition; CI, confidence interval.

3.6 Immune function

A total of five studies evaluated the effects of nutritional interventions on lymphocyte subsets in GC patients. As shown in Figure 6a, EN significantly increased CD4+ levels in GC patients compared to those without nutritional intervention (SMD = 1.09, 95% CI [0.61, 1.57], P < 0.001), which was similar to efficacy of IN and PN (P > 0.05). In addition, there was no significant difference in CD8+ levels between patients who received EN and those who received IN, PN, or no nutritional intervention (P > 0.05) (Figure 6b). A study reported that EN had a higher proportion of CD4+/CD8+ ratio compared to IN, and the pooled results of the two studies showed no significant difference in the CD4+/CD8+ proportion between EN and PN (P > 0.05) (Figure 6c). In addition, three studies compared the effects of EN and IN on immunoglobulins in GC patients, and the results showed that the IgG (SMD = −2.90, 95% CI [−3.84, −1.95], P < 0.001) and IgM (SMD = −0.99, 95% CI [−1.71, −0.26], P < 0.001) levels in patients receiving EN were significantly lower than those receiving IN (Figure S3).

Figure 6 Forest plot comparing immune function in GC patients receiving different nutritional interventions: (a) comparison of CD4+ levels in EN versus control, IN, or PN; (b) comparison of CD8+ levels in EN versus control, IN, or PN; (c) comparison of CD4+/CD8+ ratio in EN versus IN or PN. GC, gastric cancer; EN, enteral nutrition; IN, immunonutrition; PN: parenteral nutrition; CI, confidence interval.
Figure 6

Forest plot comparing immune function in GC patients receiving different nutritional interventions: (a) comparison of CD4+ levels in EN versus control, IN, or PN; (b) comparison of CD8+ levels in EN versus control, IN, or PN; (c) comparison of CD4+/CD8+ ratio in EN versus IN or PN. GC, gastric cancer; EN, enteral nutrition; IN, immunonutrition; PN: parenteral nutrition; CI, confidence interval.

3.7 Publication bias

Since the meta-analysis for each indicator included fewer than ten studies, we assessed publication bias using a funnel plot. As illustrated in Figure 7, most of the studies were evenly dispersed at both ends of the straight line, indicating a low publication bias.

Figure 7 Funnel plot for publication bias test: (a) length of hospitalization, (b) complication rates in different nutritional interventions versus control, (c) complication rates in EN versus PN or IN, (d) albumin levels, (e) prealbumin levels, (f) CD4+ levels, (g) CD8+ levels, and (h) CD4+/CD8+ ratio.
Figure 7

Funnel plot for publication bias test: (a) length of hospitalization, (b) complication rates in different nutritional interventions versus control, (c) complication rates in EN versus PN or IN, (d) albumin levels, (e) prealbumin levels, (f) CD4+ levels, (g) CD8+ levels, and (h) CD4+/CD8+ ratio.

4 Discussion

Due to its multifactorial pathophysiology, GC can cause different symptoms which compromise nutritional intake and metabolic balance, necessitating nutritional support [23]. Our findings suggest that nutritional support, particularly EN and IN, can significantly influence the clinical outcomes of GC patients.

There is abundant literature highlighting the advantages of early enteral feeding post-surgery, which not only enhances nutritional status but also accelerates the restoration of gastrointestinal function [11]. Previous studies have conflicting views on whether EN can shorten hospital stays compared to PN. Some argued that EN promotes faster recovery and reduces hospital stays by maintaining gut integrity and function [24], while some other studies indicated no difference in length of hospital stay between EN and PN groups [25]. In this study, EN showed a significant advantage over no nutritional intervention and PN in reducing hospital stay, while it did not exhibit a marked difference when compared with IN. However, there was a high heterogeneity in the comparison between EN and IN, which may be due to the fact that patients in EN group in Marano et al.’s research had more anastomosis leakage, leading to longer hospital stay [26]. Further investigation is needed as to whether the length of hospital stay is affected by the type of nutritional support.

EN was also shown to be superior over PN when time for first flatus, a primary indicator of postoperative gastrointestinal recovery, was considered. This is consistent with the established advantages of EN in promoting gut motility and function [27]. Similar to hospital stays, IN did not show significant differences compared to EN, which could imply that while IN has added immunological benefits, its impact on gastrointestinal recovery is comparable to standard EN.

In terms of nutritional status, our results showed the benefits of IN in elevating prealbumin levels. Prealbumin, also known as transthyretin, is a sensitive marker of nutritional status and has a shorter half-life than albumin, making it a more responsive indicator of recent nutritional changes. However, high heterogeneity was observed in both analysis of EN versus PN or IN in assessing prealbumin levels. When comparing EN group to PN group, both Liu et al. [13] and Li et al. [9] list similar composition and ratio of EN and PN nutrient solutions, but Chen and Zhang [17] offer no detail. It is uncertain whether this is the reason for the high heterogeneity. When comparing EN group to IN group, the high heterogeneity may come from different immunonutritional interventions. Pu et al. [18] used the whole protein compound preparation EN solution, while both studies of Liu et al. [13,15] added glutamine (Gln) (12.5 g/L) and arginine (9.0 g/L) to the EN solution. Besides, the significant rise in levels of albumin also suggested that the type of nutritional support might play a pivotal role. In summary, nutritional status was significantly improved in patients receiving EN compared to control and PN groups, which was similar to patients receiving IN. EN could play a pivotal role in enhancing the nutritional status of these patients, which might translate to better overall outcomes.

Our findings indicate no significant differences in overall complication rates among different nutritional interventions, supporting the safety of EN, IN, and ONS. This is in line with previous research demonstrating that nutritional support does not increase the risk of complications in surgical patients [28]. Furthermore, the analysis of specific complications, such as gastrointestinal adverse reactions, surgical site infections, anastomotic leakage, and pulmonary infections, revealed no significant differences between EN and IN or PN. This is a critical consideration, as the safety profile of nutritional interventions is paramount in clinical decision-making.

In this study, EN significantly enhanced immune function in GC patients, particularly by increasing CD4+ levels, which was crucial for postoperative recovery and infection resistance. This improvement in CD4+ levels indicate that EN supports the immune system more effectively [29]. It is noteworthy that while EN improved CD4+ levels, its efficacy was still surpassed by IN, similar to the results of CD8+ levels and CD4+/CD8+ ratio. However, there was high heterogeneity in the analysis of the effects of EN and IN on CD4+ and CD8+ levels. Among them, Marano’s study showed results at the level of CD4+ and CD8+ T cells that are contrary to two other publications by Liu et al. [13,15,26]. This might be because in Marano’s study, the IN group used a formula rich in arginine, omega-3, and ribonucleic acid, while Liu et al.’s study mainly used a formula with Gln. These components have different modes of action in immunomodulatory and anti-inflammatory responses, which could bring about a varied set of immunological outcomes. In addition, patient populations may also have differed. Two studies including Liu et al. included patients with advanced GC, while Marano et al.’s study included a broader population of patients with GC. Regarding the effects of EN and IN on immunoglobulins in GC patients, the levels of IgG and IgM were significantly lower in patients receiving EN, suggesting that IN may provide specific immunological advantages [30]. Therefore, tailoring nutritional interventions based on individual patient needs could optimize clinical outcomes, suggesting a need for further research in this domain to refine nutritional support strategies for GC patients.

Like all research, this study has its limitations. The exclusion of non-RCT studies, while strengthening the validity of our findings, might have led to the omission of valuable insights from observational studies, which often have larger sample sizes and real-world settings. Furthermore, the variability in the definition and types of nutritional support across the included studies could introduce heterogeneity, potentially affecting the generalizability of our findings. Besides, some research results need to be interpreted with caution due to the limited number and high heterogeneity of literature.

5 Conclusion

It is evident that nutritional interventions contribute significantly to the management and treatment of GC patients. The differential effects of IN and EN on various health outcomes underscore the need for personalized nutritional strategies tailored to individual patient needs. Future research should focus on optimizing these interventions to maximize therapeutic outcomes for GC patients.

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Acknowledgements

Not applicable.

  1. Funding information: This study was financially supported by the Hebei Province Medical Applicable Technology Tracking Project in 2022 (Grant Number: GZ2022086).

  2. Author contributions: J.Z. (Juping Zhang) conceptualized the study, participated in its design, contributed to data collection, and drafted the manuscript. Q.K. played a role in the study’s design, was responsible for data collection, and performed the statistical analysis. J.Z. (Jibo Zhang) aided in the study design, participated in data collection, contributed to data interpretation, and helped with manuscript revisions. J.G. supervised the entire study, provided crucial feedback and revisions, and gave the final approval for the version to be published. All authors have reviewed and approved the final manuscript.

  3. Conflict of interest: The authors declare no conflict of interest.

  4. Data availability statement: The data in this study are available from the corresponding author upon reasonable request.

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Received: 2024-03-11
Revised: 2024-07-25
Accepted: 2024-08-02
Published Online: 2024-09-04

© 2024 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Articles in the same Issue

  1. Research Articles
  2. EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway
  3. STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
  4. Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
  5. The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma
  6. METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
  7. Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
  8. Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty
  9. Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
  10. Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma
  11. Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue
  12. Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
  13. Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease
  14. METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients
  15. Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis
  16. Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay
  17. Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity
  18. Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound
  19. Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement
  20. miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization
  21. The analyses of human MCPH1 DNA repair machinery and genetic variations
  22. Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
  23. Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma
  24. Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
  25. The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
  26. Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis
  27. Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
  28. Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer
  29. Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke
  30. The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
  31. Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study
  32. Lactate dehydrogenase to albumin ratio is associated with in-hospital mortality in patients with acute heart failure: Data from the MIMIC-III database
  33. CD36-mediated podocyte lipotoxicity promotes foot process effacement
  34. Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
  35. FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
  36. Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
  37. Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
  38. Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition
  39. Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy
  40. Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction
  41. High SEC61A1 expression predicts poor outcome of acute myeloid leukemia
  42. Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
  43. Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway
  44. Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
  45. Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
  46. Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
  47. Clinical analysis of incomplete rupture of the uterus secondary to previous cesarean section
  48. Abnormal sleep duration is associated with sarcopenia in older Chinese people: A large retrospective cross-sectional study
  49. No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study
  50. Identification and validation of autophagy-related genes in SSc
  51. Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming
  52. Evaluation of quality of life in patients with schizophrenia: An inpatient social welfare institution-based cross-sectional study
  53. The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
  54. Compilation of a self-management assessment scale for postoperative patients with aortic dissection
  55. Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
  56. Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
  57. Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2
  58. Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
  59. High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression
  60. Factors influencing cardiovascular system-related post-COVID-19 sequelae: A single-center cohort study
  61. HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis
  62. Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
  63. Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
  64. ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
  65. Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
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  115. Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
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  118. Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
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  122. Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
  123. Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study
  124. Decreased BIRC5-206 promotes epithelial–mesenchymal transition in nasopharyngeal carcinoma through sponging miR-145-5p
  125. Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
  126. Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis
  127. Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures
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  129. Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
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  131. Parental control attitudes over their pre-school children’s diet
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  133. Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy
  134. Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin
  135. ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
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  140. Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
  141. NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages
  142. The effect of COVID-19 lockdown on admission rates in Maternity Hospital
  143. Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
  144. Luteolin alleviates cerebral ischemia/reperfusion injury by regulating cell pyroptosis
  145. Therapeutic role of respiratory exercise in patients with tuberculous pleurisy
  146. Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
  147. Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
  148. DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy
  149. Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients
  150. Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
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  153. A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022
  154. The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study
  155. Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
  156. Role of COX6C and NDUFB3 in septic shock and stroke
  157. Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
  158. Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
  159. Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation
  160. Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
  161. Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients
  162. Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
  163. Risk factors for progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fracture
  164. Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke
  165. The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
  166. Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
  167. Detection of serum FOXM1 and IGF2 in patients with ARDS and their correlation with disease and prognosis
  168. Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
  169. Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
  170. Review Articles
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  172. XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
  173. A narrative review on adverse drug reactions of COVID-19 treatments on the kidney
  174. Emerging role and function of SPDL1 in human health and diseases
  175. Adverse reactions of piperacillin: A literature review of case reports
  176. Molecular mechanism and intervention measures of microvascular complications in diabetes
  177. Regulation of mesenchymal stem cell differentiation by autophagy
  178. Molecular landscape of borderline ovarian tumours: A systematic review
  179. Advances in synthetic lethality modalities for glioblastoma multiforme
  180. Investigating hormesis, aging, and neurodegeneration: From bench to clinics
  181. Frankincense: A neuronutrient to approach Parkinson’s disease treatment
  182. Sox9: A potential regulator of cancer stem cells in osteosarcoma
  183. Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients
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  185. Maternal factors for neural tube defects in offspring: An umbrella review
  186. The chemoprotective hormetic effects of rosmarinic acid
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  188. Progress in cytokine research for ARDS: A comprehensive review
  189. Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
  190. NRXN1-related disorders, attempt to better define clinical assessment
  191. Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
  192. Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
  193. Iron in ventricular remodeling and aneurysms post-myocardial infarction
  194. Case Reports
  195. Sirolimus potentiated angioedema: A case report and review of the literature
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  199. Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review
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  204. Recurrent opportunistic infections in a HIV-negative patient with combined C6 and NFKB1 mutations: A case report, pedigree analysis, and literature review
  205. Letter to the Editor
  206. Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
  207. Erratum
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  209. Retraction
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  211. Corrigendum
  212. Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”
  213. Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
  214. Special Issue The evolving saga of RNAs from bench to bedside - Part II
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  216. Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
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  222. MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
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  225. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part I
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https://doi.org/10.1515/med-2024-1023
Keywords for this article
gastric cancer; nutritional support; enteral nutrition; immunonutrition; parenteral nutrition; meta-analysis
Creative Commons
BY 4.0

Articles in the same Issue

  1. Research Articles
  2. EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway
  3. STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
  4. Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
  5. The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma
  6. METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
  7. Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
  8. Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty
  9. Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
  10. Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma
  11. Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue
  12. Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
  13. Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease
  14. METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients
  15. Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis
  16. Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay
  17. Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity
  18. Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound
  19. Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement
  20. miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization
  21. The analyses of human MCPH1 DNA repair machinery and genetic variations
  22. Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
  23. Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma
  24. Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
  25. The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
  26. Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis
  27. Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
  28. Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer
  29. Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke
  30. The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
  31. Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study
  32. Lactate dehydrogenase to albumin ratio is associated with in-hospital mortality in patients with acute heart failure: Data from the MIMIC-III database
  33. CD36-mediated podocyte lipotoxicity promotes foot process effacement
  34. Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
  35. FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
  36. Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
  37. Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
  38. Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition
  39. Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy
  40. Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction
  41. High SEC61A1 expression predicts poor outcome of acute myeloid leukemia
  42. Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
  43. Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway
  44. Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
  45. Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
  46. Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
  47. Clinical analysis of incomplete rupture of the uterus secondary to previous cesarean section
  48. Abnormal sleep duration is associated with sarcopenia in older Chinese people: A large retrospective cross-sectional study
  49. No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study
  50. Identification and validation of autophagy-related genes in SSc
  51. Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming
  52. Evaluation of quality of life in patients with schizophrenia: An inpatient social welfare institution-based cross-sectional study
  53. The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
  54. Compilation of a self-management assessment scale for postoperative patients with aortic dissection
  55. Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
  56. Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
  57. Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2
  58. Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
  59. High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression
  60. Factors influencing cardiovascular system-related post-COVID-19 sequelae: A single-center cohort study
  61. HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis
  62. Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
  63. Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
  64. ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
  65. Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
  66. The role of enhanced expression of Cx43 in patients with ulcerative colitis
  67. Choosing a COVID-19 vaccination site might be driven by anxiety and body vigilance
  68. Role of ICAM-1 in triple-negative breast cancer
  69. Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
  70. HLA-DRB5 promotes immune thrombocytopenia via activating CD8+ T cells
  71. Efficacy and factors of myofascial release therapy combined with electrical and magnetic stimulation in the treatment of chronic pelvic pain syndrome
  72. Efficacy of tacrolimus monotherapy in primary membranous nephropathy
  73. Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking
  74. FBXO45 levels regulated ferroptosis renal tubular epithelial cells in a model of diabetic nephropathy by PLK1
  75. Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns
  76. Alpha-lipoic acid upregulates the PPARγ/NRF2/GPX4 signal pathway to inhibit ferroptosis in the pathogenesis of unexplained recurrent pregnancy loss
  77. Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study
  78. CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway
  79. miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
  80. Immune response analysis of solid organ transplantation recipients inoculated with inactivated COVID-19 vaccine: A retrospective analysis
  81. The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
  82. Clinical efficacy of dexamethasone combined with isoniazid in the treatment of tuberculous meningitis and its effect on peripheral blood T cell subsets
  83. Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis
  84. Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
  85. Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL2
  86. Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
  87. Risk factors of postoperative airway obstruction complications in children with oral floor mass
  88. Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction
  89. Physical activity and mental health trends in Korean adolescents: Analyzing the impact of the COVID-19 pandemic from 2018 to 2022
  90. Evaluating anemia in HIV-infected patients using chest CT
  91. Ponticulus posticus and skeletal malocclusion: A pilot study in a Southern Italian pre-orthodontic court
  92. Causal association of circulating immune cells and lymphoma: A Mendelian randomization study
  93. Assessment of the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals on treating renal fibrosis: A systematic review and meta-analysis
  94. Comprehensive landscape of integrator complex subunits and their association with prognosis and tumor microenvironment in gastric cancer
  95. New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: A drug Mendelian randomization study
  96. Population pharmacokinetics of meropenem in critically ill patients
  97. Comparison of the ability of newly inflammatory markers to predict complicated appendicitis
  98. Comparative morphology of the cruciate ligaments: A radiological study
  99. Immune landscape of hepatocellular carcinoma: The central role of TP53-inducible glycolysis and apoptosis regulator
  100. Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study
  101. SHP-1 mediates cigarette smoke extract-induced epithelial–mesenchymal transformation and inflammation in 16HBE cells
  102. Acute hyper-hypoxia accelerates the development of depression in mice via the IL-6/PGC1α/MFN2 signaling pathway
  103. The GJB3 correlates with the prognosis, immune cell infiltration, and therapeutic responses in lung adenocarcinoma
  104. Physical fitness and blood parameters outcomes of breast cancer survivor in a low-intensity circuit resistance exercise program
  105. Exploring anesthetic-induced gene expression changes and immune cell dynamics in atrial tissue post-coronary artery bypass graft surgery
  106. Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
  107. Analysis of the risk factors of the radiation-induced encephalopathy in nasopharyngeal carcinoma: A retrospective cohort study
  108. Reproductive outcomes in women with BRCA 1/2 germline mutations: A retrospective observational study and literature review
  109. Evaluation of upper airway ultrasonographic measurements in predicting difficult intubation: A cross-section of the Turkish population
  110. Prognostic and diagnostic value of circulating IGFBP2 in pancreatic cancer
  111. Postural stability after operative reconstruction of the AFTL in chronic ankle instability comparing three different surgical techniques
  112. Research trends related to emergence agitation in the post-anaesthesia care unit from 2001 to 2023: A bibliometric analysis
  113. Frequency and clinicopathological correlation of gastrointestinal polyps: A six-year single center experience
  114. ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
  115. Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
  116. Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
  117. The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae
  118. Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
  119. Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study
  120. Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway
  121. Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population
  122. Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
  123. Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study
  124. Decreased BIRC5-206 promotes epithelial–mesenchymal transition in nasopharyngeal carcinoma through sponging miR-145-5p
  125. Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
  126. Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis
  127. Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures
  128. The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial
  129. Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
  130. Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
  131. Parental control attitudes over their pre-school children’s diet
  132. The role of auto-HSCT in extranodal natural killer/T cell lymphoma
  133. Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy
  134. Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin
  135. ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
  136. The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study
  137. The unusual location of primary hydatid cyst: A case series study
  138. Intraoperative changes in electrophysiological monitoring can be used to predict clinical outcomes in patients with spinal cavernous malformation
  139. Obesity and risk of placenta accreta spectrum: A meta-analysis
  140. Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
  141. NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages
  142. The effect of COVID-19 lockdown on admission rates in Maternity Hospital
  143. Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
  144. Luteolin alleviates cerebral ischemia/reperfusion injury by regulating cell pyroptosis
  145. Therapeutic role of respiratory exercise in patients with tuberculous pleurisy
  146. Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
  147. Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
  148. DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy
  149. Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients
  150. Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
  151. Ferroptosis-related prognostic model of mantle cell lymphoma
  152. Observation of choking reaction and other related indexes in elderly painless fiberoptic bronchoscopy with transnasal high-flow humidification oxygen therapy
  153. A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022
  154. The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study
  155. Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
  156. Role of COX6C and NDUFB3 in septic shock and stroke
  157. Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
  158. Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
  159. Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation
  160. Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
  161. Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients
  162. Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
  163. Risk factors for progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fracture
  164. Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke
  165. The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
  166. Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
  167. Detection of serum FOXM1 and IGF2 in patients with ARDS and their correlation with disease and prognosis
  168. Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
  169. Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
  170. Review Articles
  171. Cutaneous signs of selected cardiovascular disorders: A narrative review
  172. XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
  173. A narrative review on adverse drug reactions of COVID-19 treatments on the kidney
  174. Emerging role and function of SPDL1 in human health and diseases
  175. Adverse reactions of piperacillin: A literature review of case reports
  176. Molecular mechanism and intervention measures of microvascular complications in diabetes
  177. Regulation of mesenchymal stem cell differentiation by autophagy
  178. Molecular landscape of borderline ovarian tumours: A systematic review
  179. Advances in synthetic lethality modalities for glioblastoma multiforme
  180. Investigating hormesis, aging, and neurodegeneration: From bench to clinics
  181. Frankincense: A neuronutrient to approach Parkinson’s disease treatment
  182. Sox9: A potential regulator of cancer stem cells in osteosarcoma
  183. Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients
  184. Advanced neuroimaging and criminal interrogation in lie detection
  185. Maternal factors for neural tube defects in offspring: An umbrella review
  186. The chemoprotective hormetic effects of rosmarinic acid
  187. CBD’s potential impact on Parkinson’s disease: An updated overview
  188. Progress in cytokine research for ARDS: A comprehensive review
  189. Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
  190. NRXN1-related disorders, attempt to better define clinical assessment
  191. Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
  192. Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
  193. Iron in ventricular remodeling and aneurysms post-myocardial infarction
  194. Case Reports
  195. Sirolimus potentiated angioedema: A case report and review of the literature
  196. Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report
  197. Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman’s disease: A case report
  198. Complete heart block associated with hepatitis A infection in a female child with fatal outcome
  199. Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review
  200. Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
  201. Advancing prenatal diagnosis: Echocardiographic detection of Scimitar syndrome in China – A case series
  202. Outcomes and complications of hemodialysis in patients with renal cancer following bilateral nephrectomy
  203. Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy
  204. Recurrent opportunistic infections in a HIV-negative patient with combined C6 and NFKB1 mutations: A case report, pedigree analysis, and literature review
  205. Letter to the Editor
  206. Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
  207. Erratum
  208. Erratum to “Bladder-embedded ectopic intrauterine device with calculus”
  209. Retraction
  210. Retraction of “XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis”
  211. Corrigendum
  212. Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”
  213. Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
  214. Special Issue The evolving saga of RNAs from bench to bedside - Part II
  215. Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma
  216. Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
  217. Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment
  218. Special Issue Advancements in oncology: bridging clinical and experimental research - Part I
  219. Ultrasound-guided transperineal vs transrectal prostate biopsy: A meta-analysis of diagnostic accuracy and complication rates
  220. Assessment of diagnostic value of unilateral systematic biopsy combined with targeted biopsy in detecting clinically significant prostate cancer
  221. SENP7 inhibits glioblastoma metastasis and invasion by dissociating SUMO2/3 binding to specific target proteins
  222. MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
  223. Analysis of postoperative complications in bladder cancer patients
  224. Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study
  225. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part I
  226. Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma
  227. Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer
  228. Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis
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