Home Medicine The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial
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The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial

  • Xuandong Jia EMAIL logo and Min Wang
Published/Copyright: September 23, 2024
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Open Medicine
From the journal Open Medicine Volume 19 Issue 1

Abstract

To observe the effect of intravenous general anesthesia under nasopharyngeal airway-assisted ventilation on patients undergoing ureteroscopic holmium laser lithotripsy. One hundred and twenty patients who underwent ureteroscopic holmium laser lithotripsy in our hospital were selected and randomly divided into nasopharyngeal airway group (research group) and laryngeal mask group (control group). These patients, respectively, received intravenous anesthesia under nasopharyngeal airway and laryngeal mask-assisted ventilation. The following evaluation indexes were compared and analyzed between the two groups, including anesthetic effect, hemodynamics, stress response, postoperative recovery, adverse reactions, etc. There were no significant differences in Visual Analog Scale, hemodynamics, and stress response between the two groups at each time point (P > 0.05). There were no significant differences in residence time and postoperative recovery time between the two groups (P > 0.05). The difference in airway establishment time between the two groups was statistically significant (P < 0.05), and cases with blood in the research group was significantly lower than those in the control group (P < 0.05). Patient satisfaction in research group was significantly higher than those in the control group (P < 0.05). The clinical effect of intravenous general anesthesia under nasopharyngeal airway-assisted ventilation in ureteroscopic holmium laser lithotripsy is significant, which helps to stabilize patients’ hemodynamics, reduce their stress response and adverse reactions, and improve the satisfaction rate of patient.

Keywords: ureteroscopic holmium laser lithotripsy; nasopharyngeal airway; laryngeal mask; intravenous general anesthesia

1 Introduction

The incidence rate of ureteral calculi is increasing year after year with the change of people’s living habits and diet structure [1]. If not treated in time, it may cause ureteral obstruction, hydronephrosis, or pyonephrosis, increasing the probability of ureteral and renal damage, and also increase the difficulty of treatment to a certain extent [2,3]. Ureteroscopic holmium laser lithotripsy has the advantages of minimally invasive, significant effect, and short recovery time, making it a safe and effective way to treat ureteral stones [4]. It has been widely accepted by physicians and patients [5]. However, the anesthesia method for this surgery has always been controversial. If the analgesic and sedative effect is not good during the operation, it can easily lead to patient restlessness, lack of cooperation, and even ureteral perforation, which will seriously affect the prognosis [6]. With the application of accelerated rehabilitation concept in urology, ureteroscopy holmium laser lithotripsy, a minimally invasive surgery, still requires the use of precise anesthesia plan to prevent damage to the function of organ tissues caused by surgical and anesthesia operations during the perioperative period. How to reduce stress response and promote prognosis recovery has gradually become the focus of attention for the above surgery [7]. In the past, spinal anesthesia methods were often chosen, but these methods can easily increase patient discomfort and even lead to complications [4,7]. At present, most surgeries choose tracheal intubation or laryngeal mask general anesthesia in the general anesthesia scheme. Literature [8,9] believed that ureteroscopy holmium laser lithotripsy was relatively more suitable under general anesthesia, and also provided the advantages of laryngeal mask general anesthesia compared to tracheal intubation. However, there are relatively few published studies on the application of intravenous general anesthesia under nasopharyngeal airway-assisted ventilation in ureteroscopic holmium laser lithotripsy. Chen et al. applied the general anesthesia scheme under nasopharyngeal airway-assisted ventilation to retinal laser surgery in low body weight newborns, and compared it with the laryngeal mask group and tracheal intubation group. It was found that the nasopharyngeal airway group had significant advantages in postoperative hemodynamic indicators [10]. Therefore, the application of intravenous general anesthesia under nasopharyngeal airway-assisted ventilation in ureteroscopic holmium laser lithotripsy is a new exploration. This article explores the application effect of intravenous general anesthesia under nasopharyngeal airway-assisted ventilation in ureteroscopic holmium laser lithotripsy by observing indexes such as anesthesia efficacy, hemodynamic parameters, and stress response. The current reports are as follows.

2 Information and methodology

2.1 General information

One hundred and twenty patients with ureteral stones who underwent ureteroscopic holmium laser lithotripsy at our hospital from January 2023 to December 2023 were selected as the study subjects. Intraoperative anesthesia was performed under intravenous general anesthesia. According to different ventilation modes, patients were randomly divided into a nasopharyngeal airway group (research group) and a laryngeal mask group (control group) using a random number table method, with 60 cases in each group. Inclusion criteria included: (1) complete clinical data, (2) consistent with the diagnosis of upper and middle ureteral stones, with a stone diameter of <1.5 cm, (3) meets the surgical indications for ureteroscopic holmium laser lithotripsy, and (4) there is no history of allergy to the drugs used in the study. Exclusion criteria were (1) individuals with a history of urological surgery or urethral stricture who are unable to undergo endoscopy; (2) severe liver and kidney lesions, concurrent tumors, hemorrhagic diseases, and severe spinal deformities; (3) concomitant mental illness; (4) patients with hypertension, diabetes, and other complications that are not well controlled before surgery; (5) individuals with a history of sleep apnea, nasal malformations, rhinitis, nosebleeds, or nasal surgery, as well as other respiratory diseases; and (6) patients with contraindications to laryngeal mask application such as habitual reflux and other contraindications to anesthesia.

2.2 Anesthesia methods

Prior to surgery, all patients were routinely prohibited from drinking or eating. After entering the operating room, the peripheral venous channel was opened to monitor routine indicators such as electrocardiogram, blood oxygen saturation, heart rate, blood pressure, and Bis, and administer oxygen with a mask (5 L/min).

Research group: Patients were given intravenous infusion of 2 mg of hydromorphone hydrochloride injection, and intravenous pump of dexmedetomidine hydrochloride at a loading dose of 1 µg/mL for 10 min. The maintenance dose of dexmedetomidine hydrochloride was changed to 0.2–0.7 µg/(kg h). Intravenous infusion of 10 mg/mL propofol and 10 µg/mL remifentanil, in plasma target control mode, Marsh model, and Minto model were selected, respectively. The target concentrations of propofol and remifentanil were loaded with 2.5–35 and 3.5–4.5 ng/mL, respectively. When the patient’s eyelash reflex disappeared and the anesthesia depth Bis value decreased to 60, the nasopharyngeal airway was inserted, and then the anesthesia machine respiratory circuit was connected through a mask, set to manual control mode, and pure oxygen was inhaled for 5 L/min. The maintenance doses of propofol and remifentanil were changed to 1.5–2.5 and 2.5–3.5 ng/mL, respectively.

The drug concentration has reached its peak at this time and the patient’s breathing condition needs to be observed. If breathing pauses occur, brief artificial ventilation should be given until the patient’s spontaneous breathing is restored. The patient’s spontaneous breathing should be retained during surgery, and the Bis value should be maintained between 50 and 60. During surgery, research group may encounter the following situations: (1) SpO2 < 92%, patients should be provided with mandibular support and face mask pressure oxygen supply. If necessary, tracheal intubation is performed. (2) When blood pressure is 20% lower than the preoperative baseline, vasoactive drugs such as ephedrine or hydroxylamine should be administered to patients. (3) Body movement reaction, administer a BOLUS dose of propofol/remifentanil until the body movement reaction disappears.

Control group: Laryngeal mask general anesthesia was used, and patients were intravenously injected with midazolam 0.03 mg/kg, propofol 1 mg/kg, sufentanil 0.5 µg/kg, and rocuronium 0.6 mg/kg for anesthesia induction. After induction, a laryngeal mask (Tampa, single lumen steel wire reinforced type) was inserted. Intravenous infusion of 3–4 mg/(kg h) propofol and 3–4 µg/(kg h) remifentanil was administered for anesthesia maintenance. If there is a leakage or displacement of the laryngeal mask during surgery, resulting in insufficient ventilation and a decrease in SpO2, and the patient still does not improve after adjusting the position of the laryngeal mask, deepening anesthesia, or adding muscle relaxants, emergency tracheal intubation should be performed.

2.3 Observation indicators

Observation indicators mainly included: (1) Hemodynamics: Using the Mindray BeneView T6 monitor, monitor the hemodynamic parameters of the two groups of patients before anesthesia induction (T0), at the time of insertion of a laryngeal mask or nasopharyngeal airway (T1), and at the time of extraction (T2), including mean arterial pressure (MAP), heart rate (HR), and pulse oxygen saturation (SpO2). (2) Stress response: Measure the serum cortisol (Cor) and norepinephrine (NE) levels of patients. Detection method: Before surgery (T3) and 0.5 h (T5), 6 h (T6), and 24 h (T8) after surgery, 3 mL of venous blood was collected from patients, maintained at a rate of 3,000 r/min, and centrifuged for 10 min to obtain serum. The patient’s Cor and NE were detected using Roche electrochemiluminescence method. (3) Anesthesia effect: Evaluate the patient’s awakening time (T4) and subjective pain sensation and retention time at 6 h (T6), 12 h (T7), 24 h (T8), and 48 h (T9) after surgery. Among them, subjective pain perception was evaluated using the Visual Analog Scale (VAS), with a score of 0–10, and the higher the score, the more severe the pain [11,12]. The retention time refers to the time from preoperative preparation to postoperative recovery of the patient in the operating room. (4) Postoperative recovery: The patient’s postoperative recovery time and perioperative satisfaction. Among them, patient satisfaction is measured through a self-made questionnaire survey, which is divided into three levels: very satisfied, satisfied, and dissatisfied. (5) Establishment of airway time: Refer to the time required from placing a nasopharyngeal airway or laryngeal mask to achieving ventilation. (6) Adverse reactions: Including the following situations: SpO2 < 92%, body movement, number of unplanned tracheal intubation cases, and number of cases with blood on the surface after removing the airway (used to evaluate mucosal damage, abbreviated as bleeding cases) [13].

2.4 Statistical analysis

Statistical data were analyzed using SPSS 22.0 software. The measurement data are represented by mean and standard deviation, and independent sample t-test is used for intergroup comparison. In the study, hemodynamic indicators, stress response indicators, VAS scores at different times, retention time, and postoperative recovery time are used as measurement data. The count data are represented by n (%), and χ 2 test is used in intergroup comparison. Patient satisfaction and adverse reactions in the study are the count data. P < 0.05 is considered statistically significant.

  1. Ethical approval: This study was approved by the Medical Ethics Committee of our hospital.

  2. Informed consent: Informed consent form was signed by the patients.

3 Results

3.1 Demographic data

There was no statistically significant difference in general information such as gender, age, disease course, and stone diameter between the two groups (P > 0.05), as shown in Table 1.

Table 1

Comparison of general situation between the two groups

Index Research group (n = 60) Control group (n = 60) t/χ 2 P
Male [n (%)] 36 (60.00) 37 (61.67) 0.035 0.852
Female [n (%)] 24 (40.00) 23 (38.33)
Age 41.51 ± 7.56 42.81 ± 8.66 −0.883 0.379
Disease course (month) 21.10 ± 3.16 21.62 ± 2.58 −0.993 0.323
Stone diameter (cm) 1.12 ± 0.46 1.11 ± 0.34 0.252 0.801

3.2 Comparison of hemodynamics between two groups of patients

The distribution and mean value of HR, MAP, and SpO2 of the two groups at T0, T1, and T2 are shown in Figures 1–3. Taking the distribution of the measured values of HR of the S group at T0 as an example, the box diagram contains the upper adjacent, lower adjacent, and median of the distribution of the measured values. The box part represents the interval of most measured values.

Figure 1 Distribution and mean value of MAP of the two groups.
Figure 1

Distribution and mean value of MAP of the two groups.

Figure 2 Distribution and mean value of HR of the two groups.
Figure 2

Distribution and mean value of HR of the two groups.

Figure 3 Distribution and mean value of SpO2 of the two groups.
Figure 3

Distribution and mean value of SpO2 of the two groups.

The MAP and HR at T1 were significantly lower than those at T0 and T2 (P < 0.05), and there was no significant difference in SpO2 at each time point (P > 0.05) between the two groups of patients. There was no significant difference in MAP, HR, and SpO2 between the two groups of patients at different time points (P > 0.05), as shown in Table 2.

Table 2

Comparison of hemodynamic parameters between the two groups (x̄ ± s)

Index Research group (n = 60) Control group (n = 60) t P
MAP (mmHg)
T0 88.72 ± 6.44* 89.31 ± 6.78* −0.482 0.631
T1 79.64 ± 4.41 80.81 ± 3.44 −1.397 0.165
T2 85.21 ± 4.01* 86.42 ± 4.21* −1.612 0.110
HR (times/min)
T0 79.51 ± 14.68* 79.77 ± 14.84* −0.096 0.924
T1 70.26 ± 15.14 72.19 ± 15.23 −0.679 0.498
T2 76.14 ± 16.03* 78.97 ± 15.99* −0.971 0.334
SpO 2 (%)
T0 98.87 ± 0.82 98.81 ± 0.90 0.370 0.712
T1 97.95 ± 1.22 98.34 ± 1.31 −1.209 0.230
T2 98.16 ± 0.90 97.95 ± 0.80 1.312 0.192

Note: Compared to T1 time, *P < 0.05 for other time points within the group.

3.3 Comparison of stress responses between two groups of patients

The distribution and mean value of Cor and NE in the two groups after operation are shown in Figures 4 and 5. There was no significant difference in the Cor between the two groups at T3, T5, T6, T8 (P > 0.05). Compared with the Cor of patients in both groups in T3, the Cor of patients in both groups significantly increased at T5, T6, T8 (P < 0.05). There was no significant difference in the NE between the two groups at T3, T5, T6, T8 (P > 0.05). Compared with the NE of patients in both groups in T3, the NE of patients in both groups significantly increased at T5, T6, T8 (P < 0.05), as shown in Table 3.

Figure 4 Distribution and mean value of Cor of the two groups.
Figure 4

Distribution and mean value of Cor of the two groups.

Figure 5 Distribution and mean value of NE of the two groups.
Figure 5

Distribution and mean value of NE of the two groups.

Table 3

Comparison of stress responses between the two groups (x̄ ± s)

Index Research group (n = 60) Control group (n = 60) t P
Cor (nmol/L)
T3 276.46 ± 20.59 276.80 ± 20.25 −0.106 0.916
T5 398.67 ± 22.41* 402.16 ± 25.24* −0.766 0.445
T6 369.92 ± 21.01* 371.73 ± 23.61* −0.470 0.639
T8 335.87 ± 26.50* 342.34 ± 27.49* −1.333 0.185
NE (pg/L)
T3 214.32 ± 10.14 213.81 ± 10.89 0.255 0.799
T5 286.12 ± 17.36* 290.61 ± 15.83* −1.475 0.143
T6 256.12 ± 13.95* 261.35 ± 14.86* −1.949 0.054
T8 228.55 ± 25.44* 233.13 ± 27.65* −9.69 0.335

Note: Compared to preoperative time, *P < 0.05 was observed at other times within the group.

3.4 Comparison of VAS scores between two groups of patients at different postoperative times

The distribution and mean value of VAS scores of patients in the two groups after operation are shown in Figure 6. There was no statistically significant difference (P > 0.05) in the VAS scores of the two groups of patients at each postoperative time, as shown in Table 4.

Figure 6 Distribution and mean value of VAS of the two groups.
Figure 6

Distribution and mean value of VAS of the two groups.

Table 4

Comparison of VAS scores between the two groups at different time after operation (x̄ ± s)

VAS score Research group (n = 60) Control group (n = 60) t P
T4 2.86 ± 0.59 3.01 ± 0.39 −1.693 0.093
T6 2.56 ± 0.53 2.74 ± 0.75 −1.570 0.119
T7 2.21 ± 0.27 2.32 ± 0.34 −1.021 0.309
T8 2.07 ± 0.47 2.14 ± 0.37 −0.907 0.367
T9 1.89 ± 0.21 1.94 ± 0.47 −0.597 0.552

3.5 Comparison of retention time, airway establishment time, postoperative recovery time, and patient satisfaction between two groups of patients

There was no statistically significant difference in the retention time and postoperative recovery time between the two groups of patients (P > 0.05). There was a statistically significant difference (P < 0.05) in the time and satisfaction of establishing airways between the two groups of patients, as shown in Table 5.

Table 5

The retention time, postoperative recovery time, time for airway establishment, and patient satisfaction of the two groups [(x̄ ± s), n (%)]

Index Research group (n = 60) Control group (n = 60) t/χ2 P
Detention time (min) 61.19 ± 15.93 63.71 ± 16.13 −0.861 0.391
Establishing airway time (s) 13.42 ± 2.43 28.37 ± 3.97 −24.774 0.000
Postoperative recovery time (days) 4.77 ± 1.55 4.89 ± 1.54 −0.430 0.668
Patient satisfaction [n (%)] 59 (98.33) 53 (88.33) 4.821 0.028

3.6 Comparison of adverse reactions between two groups of patients

The number of cases with blood in the control group was significantly higher than that in the research group, and the difference was statistically significant (P < 0.05), as shown in Table 6.

Table 6

Comparison of adverse reactions between the two groups [n (%)]

Index Research group (n = 60) Control group (n = 60) χ 2 P
SpO2 < 92% [n (%)] 2 (3.33) 1 (1.67) 0.342 0.559
Physical movement [n (%)] 1 (1.67) 0 (0.00) 1.008 0.315
Number of cases with blood [n (%)] 3 (5.00) 12 (20.00) 6.171 0.013
Unplanned tracheal intubation n [(%)] 0 (0.00) 1 (1.67) 1.008 0.315

4 Discussion

Ureteroscopic holmium laser lithotripsy requires high standards for anesthesia. While general anesthesia offers rapid onset, effective anesthesia, and high stone clearance rates, it also brings about delays in recovery, pulmonary complications, and hemodynamic fluctuations. This is especially true for tracheal intubation general anesthesia, which significantly elevates patients’ stress responses. In particular, general anesthesia with tracheal intubation will greatly increase the patient’s stress response [2,3,14]. The surgery and anesthesia method have a significant impact on hemodynamics and stress level of patients. Therefore, optimizing the anesthesia method and selecting anesthetic drugs reasonably can be used to reduce the impact of surgery and anesthesia on hemodynamics and stress level. Research indicates that the use of laryngeal mask general anesthesia in ureteroscopic holmium laser lithotripsy supports stable hemodynamics and reduces stress responses in patients. However, there are also issues such as poor sealing effect, increased oral secretions, and affecting patient comfort [15,16]. Nasopharyngeal airway-assisted ventilation can fully preserve the patient’s autonomous breathing, and its application in intravenous anesthesia can quickly alleviate respiratory obstruction and prevent intraoperative hypoxemia [17]. Therefore, it is worth exploring whether the application of intravenous general anesthesia under nasopharyngeal airway-assisted ventilation in ureteroscopic holmium laser lithotripsy can achieve better results in clinical application.

Related studies have found that the application of propofol remifentanil combined with laryngeal mask ventilation in ureteroscopic holmium laser lithotripsy has a significant anesthetic effect, can maintain patient hemodynamic stability, and help reduce patient stress response [15,16]. The results of this study showed that there were no significant differences in VAS scores, hemodynamic indicators, and stress response indicators between the research group and the control group at various postoperative times. The above results indicate that the application of intravenous general anesthesia under nasopharyngeal airway-assisted ventilation in ureteroscopic holmium laser lithotripsy has a significant effect, which could achieve the same effect as general anesthesia with laryngeal mask and further verifies the conclusions of refs [15,16].

The underlying cause was examined from the standpoint of the anesthesia protocol. The control group employed traditional general anesthesia with laryngeal masks, whereas the research group utilized intravenous general anesthesia supported by nasopharyngeal airway ventilation. Dexmedetomidine and hydromorphone were co-administered during the procedure. As a new type of highly selective α-2 adrenergic receptor agonist, dexmedetomidine can reduce the response of adrenergic nerves to pain stimuli by inhibiting sympathetic nerve excitation, effectively inhibiting patient sympathetic activity, achieving advantages such as pain relief, sedation, and respiratory inhibition. When used in compound anesthesia surgery, dexmedetomidine can effectively improve patient’s awakening quality, buffer blood pressure fluctuations, maintain hemodynamic stability, and alleviate patient stress reactions [18,19]. Hydromorphone is a semi-synthetic opioid drug, which belongs to opioid receptor agonist. It can act on opioid δ receptor and μ receptor to achieve analgesic effect. It can also regulate the absorption and release of neurotransmitters, effectively reduce patient stress reactions, improve patient inflammation levels, and promote more stable hemodynamic fluctuations [20,21]. From the perspective of ventilation tools, compared with the laryngeal mask airway, the nasopharynx airway in the research group is a kind of non-endotracheal tube airway with soft material and placed outside the acoustic door. It has the advantages of shallow insertion depth and less stimulation. Compared with the laryngeal mask, it does not cause irritation to the tracheal mucosa or compression of the airbag. Besides, patients have good tolerance to nasopharynx airway, which helps maintain a stable internal environment and effectively alleviate stress reactions. In addition, some scholars believe that the use of nasopharyngeal airway-assisted ventilation is convenient for anesthesiologists to manage the patient’s breathing and circulation during surgery, thereby reducing the risk of fluctuations, maintaining relative stability of patient hemodynamic indicators, and alleviating stress reactions [22].

The research results also showed that there was no significant difference in retention time and postoperative recovery time between the two groups of patients. There was no significant difference in the number of intraoperative SpO2 < 92%, body movement response, and unplanned tracheal intubation between the two groups of patients, further indicating that both ventilation modes of general anesthesia can achieve good anesthesia effects. It is worth mentioning that there were two cases of tongue falling back in the research group, resulting in SpO2 < 92%, and SpO2 immediately increased to more than 98% after mandible support. In the control group, there was one case of displacement of the laryngeal mask. After adjusting the position and deepening anesthesia, ventilation was still unable to improve, leading to emergency tracheal intubation after SpO2 < 92%. The possible reasons may be that the laryngeal mask will undergo force deformation after inflation and there is no easily fixed physical structure. Due to factors such as the depth of anesthesia and changes in patient positioning, there is a risk of rotation and displacement, which can lead to inadequate ventilation and decreased pulse oximetry. The research group exhibited a significantly shorter airway establishment time compared to the control group. The possible reason is that the laryngeal mask has poor airtightness combined with individual anatomical differences, making it prone to air leakage. After placement, the laryngeal mask may be necessary to adjust the position until there is no air leakage. The above analysis also indicates that the placement of the nasopharyngeal airway is easier and the operation is simpler and more feasible. Patients in the research group reported significantly higher levels of satisfaction compared to those in the control group. This is attributed to the fact that the placement of laryngeal mask often leads to postoperative pain and discomfort in the throat area. In contrast, patients exhibited greater tolerance toward nasopharyngeal airway. Nevertheless, the incidence of bleeding cases during general anesthesia with laryngeal mask was notably higher than that with nasopharyngeal airway. The reason is speculated that the placement of the laryngeal mask requires more physiological bending structures, and there is a certain pressure when inflating and sealing the laryngeal cavity. Due to individual differences in patients and inflating pressure, it is easy to cause mucosal damage [23].

In summary, general anesthesia under nasopharyngeal airway or laryngeal mask ventilation modes can meet the requirements of sedation and analgesia for this surgery, with comparable anesthesia effects, which is beneficial for patient hemodynamic stability and reducing stress reactions. However, the operation of intravenous general anesthesia under nasopharyngeal airway-assisted ventilation is simpler, which can further reduce postoperative mucosal damage and other adverse reactions, improve patient satisfaction, and has certain promotion and application value in clinical practice.

Acknowledgements

Not applicable.

  1. Funding information: General research project under the management of the institute (MS202113).

  2. Author contributions: Xuandong Jia conceived of the study and conducted the trials. Min Wang drafted the manuscript. All authors read and approved the final manuscript.

  3. Conflict of interest: The authors declare no conflicts of interest.

  4. Data availability statement: Data used for the analysis in this study are within this article.

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Received: 2024-06-16
Revised: 2024-08-21
Accepted: 2024-08-27
Published Online: 2024-09-23

© 2024 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Articles in the same Issue

  1. Research Articles
  2. EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway
  3. STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
  4. Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
  5. The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma
  6. METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
  7. Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
  8. Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty
  9. Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
  10. Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma
  11. Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue
  12. Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
  13. Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease
  14. METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients
  15. Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis
  16. Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay
  17. Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity
  18. Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound
  19. Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement
  20. miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization
  21. The analyses of human MCPH1 DNA repair machinery and genetic variations
  22. Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
  23. Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma
  24. Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
  25. The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
  26. Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis
  27. Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
  28. Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer
  29. Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke
  30. The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
  31. Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study
  32. Lactate dehydrogenase to albumin ratio is associated with in-hospital mortality in patients with acute heart failure: Data from the MIMIC-III database
  33. CD36-mediated podocyte lipotoxicity promotes foot process effacement
  34. Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
  35. FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
  36. Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
  37. Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
  38. Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition
  39. Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy
  40. Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction
  41. High SEC61A1 expression predicts poor outcome of acute myeloid leukemia
  42. Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
  43. Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway
  44. Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
  45. Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
  46. Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
  47. Clinical analysis of incomplete rupture of the uterus secondary to previous cesarean section
  48. Abnormal sleep duration is associated with sarcopenia in older Chinese people: A large retrospective cross-sectional study
  49. No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study
  50. Identification and validation of autophagy-related genes in SSc
  51. Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming
  52. Evaluation of quality of life in patients with schizophrenia: An inpatient social welfare institution-based cross-sectional study
  53. The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
  54. Compilation of a self-management assessment scale for postoperative patients with aortic dissection
  55. Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
  56. Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
  57. Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2
  58. Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
  59. High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression
  60. Factors influencing cardiovascular system-related post-COVID-19 sequelae: A single-center cohort study
  61. HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis
  62. Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
  63. Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
  64. ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
  65. Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
  66. The role of enhanced expression of Cx43 in patients with ulcerative colitis
  67. Choosing a COVID-19 vaccination site might be driven by anxiety and body vigilance
  68. Role of ICAM-1 in triple-negative breast cancer
  69. Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
  70. HLA-DRB5 promotes immune thrombocytopenia via activating CD8+ T cells
  71. Efficacy and factors of myofascial release therapy combined with electrical and magnetic stimulation in the treatment of chronic pelvic pain syndrome
  72. Efficacy of tacrolimus monotherapy in primary membranous nephropathy
  73. Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking
  74. FBXO45 levels regulated ferroptosis renal tubular epithelial cells in a model of diabetic nephropathy by PLK1
  75. Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns
  76. Alpha-lipoic acid upregulates the PPARγ/NRF2/GPX4 signal pathway to inhibit ferroptosis in the pathogenesis of unexplained recurrent pregnancy loss
  77. Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study
  78. CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway
  79. miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
  80. Immune response analysis of solid organ transplantation recipients inoculated with inactivated COVID-19 vaccine: A retrospective analysis
  81. The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
  82. Clinical efficacy of dexamethasone combined with isoniazid in the treatment of tuberculous meningitis and its effect on peripheral blood T cell subsets
  83. Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis
  84. Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
  85. Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL2
  86. Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
  87. Risk factors of postoperative airway obstruction complications in children with oral floor mass
  88. Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction
  89. Physical activity and mental health trends in Korean adolescents: Analyzing the impact of the COVID-19 pandemic from 2018 to 2022
  90. Evaluating anemia in HIV-infected patients using chest CT
  91. Ponticulus posticus and skeletal malocclusion: A pilot study in a Southern Italian pre-orthodontic court
  92. Causal association of circulating immune cells and lymphoma: A Mendelian randomization study
  93. Assessment of the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals on treating renal fibrosis: A systematic review and meta-analysis
  94. Comprehensive landscape of integrator complex subunits and their association with prognosis and tumor microenvironment in gastric cancer
  95. New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: A drug Mendelian randomization study
  96. Population pharmacokinetics of meropenem in critically ill patients
  97. Comparison of the ability of newly inflammatory markers to predict complicated appendicitis
  98. Comparative morphology of the cruciate ligaments: A radiological study
  99. Immune landscape of hepatocellular carcinoma: The central role of TP53-inducible glycolysis and apoptosis regulator
  100. Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study
  101. SHP-1 mediates cigarette smoke extract-induced epithelial–mesenchymal transformation and inflammation in 16HBE cells
  102. Acute hyper-hypoxia accelerates the development of depression in mice via the IL-6/PGC1α/MFN2 signaling pathway
  103. The GJB3 correlates with the prognosis, immune cell infiltration, and therapeutic responses in lung adenocarcinoma
  104. Physical fitness and blood parameters outcomes of breast cancer survivor in a low-intensity circuit resistance exercise program
  105. Exploring anesthetic-induced gene expression changes and immune cell dynamics in atrial tissue post-coronary artery bypass graft surgery
  106. Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
  107. Analysis of the risk factors of the radiation-induced encephalopathy in nasopharyngeal carcinoma: A retrospective cohort study
  108. Reproductive outcomes in women with BRCA 1/2 germline mutations: A retrospective observational study and literature review
  109. Evaluation of upper airway ultrasonographic measurements in predicting difficult intubation: A cross-section of the Turkish population
  110. Prognostic and diagnostic value of circulating IGFBP2 in pancreatic cancer
  111. Postural stability after operative reconstruction of the AFTL in chronic ankle instability comparing three different surgical techniques
  112. Research trends related to emergence agitation in the post-anaesthesia care unit from 2001 to 2023: A bibliometric analysis
  113. Frequency and clinicopathological correlation of gastrointestinal polyps: A six-year single center experience
  114. ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
  115. Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
  116. Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
  117. The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae
  118. Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
  119. Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study
  120. Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway
  121. Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population
  122. Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
  123. Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study
  124. Decreased BIRC5-206 promotes epithelial–mesenchymal transition in nasopharyngeal carcinoma through sponging miR-145-5p
  125. Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
  126. Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis
  127. Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures
  128. The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial
  129. Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
  130. Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
  131. Parental control attitudes over their pre-school children’s diet
  132. The role of auto-HSCT in extranodal natural killer/T cell lymphoma
  133. Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy
  134. Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin
  135. ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
  136. The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study
  137. The unusual location of primary hydatid cyst: A case series study
  138. Intraoperative changes in electrophysiological monitoring can be used to predict clinical outcomes in patients with spinal cavernous malformation
  139. Obesity and risk of placenta accreta spectrum: A meta-analysis
  140. Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
  141. NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages
  142. The effect of COVID-19 lockdown on admission rates in Maternity Hospital
  143. Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
  144. Luteolin alleviates cerebral ischemia/reperfusion injury by regulating cell pyroptosis
  145. Therapeutic role of respiratory exercise in patients with tuberculous pleurisy
  146. Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
  147. Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
  148. DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy
  149. Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients
  150. Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
  151. Ferroptosis-related prognostic model of mantle cell lymphoma
  152. Observation of choking reaction and other related indexes in elderly painless fiberoptic bronchoscopy with transnasal high-flow humidification oxygen therapy
  153. A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022
  154. The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study
  155. Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
  156. Role of COX6C and NDUFB3 in septic shock and stroke
  157. Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
  158. Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
  159. Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation
  160. Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
  161. Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients
  162. Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
  163. Risk factors for progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fracture
  164. Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke
  165. The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
  166. Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
  167. Detection of serum FOXM1 and IGF2 in patients with ARDS and their correlation with disease and prognosis
  168. Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
  169. Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
  170. Review Articles
  171. Cutaneous signs of selected cardiovascular disorders: A narrative review
  172. XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
  173. A narrative review on adverse drug reactions of COVID-19 treatments on the kidney
  174. Emerging role and function of SPDL1 in human health and diseases
  175. Adverse reactions of piperacillin: A literature review of case reports
  176. Molecular mechanism and intervention measures of microvascular complications in diabetes
  177. Regulation of mesenchymal stem cell differentiation by autophagy
  178. Molecular landscape of borderline ovarian tumours: A systematic review
  179. Advances in synthetic lethality modalities for glioblastoma multiforme
  180. Investigating hormesis, aging, and neurodegeneration: From bench to clinics
  181. Frankincense: A neuronutrient to approach Parkinson’s disease treatment
  182. Sox9: A potential regulator of cancer stem cells in osteosarcoma
  183. Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients
  184. Advanced neuroimaging and criminal interrogation in lie detection
  185. Maternal factors for neural tube defects in offspring: An umbrella review
  186. The chemoprotective hormetic effects of rosmarinic acid
  187. CBD’s potential impact on Parkinson’s disease: An updated overview
  188. Progress in cytokine research for ARDS: A comprehensive review
  189. Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
  190. NRXN1-related disorders, attempt to better define clinical assessment
  191. Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
  192. Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
  193. Iron in ventricular remodeling and aneurysms post-myocardial infarction
  194. Case Reports
  195. Sirolimus potentiated angioedema: A case report and review of the literature
  196. Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report
  197. Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman’s disease: A case report
  198. Complete heart block associated with hepatitis A infection in a female child with fatal outcome
  199. Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review
  200. Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
  201. Advancing prenatal diagnosis: Echocardiographic detection of Scimitar syndrome in China – A case series
  202. Outcomes and complications of hemodialysis in patients with renal cancer following bilateral nephrectomy
  203. Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy
  204. Recurrent opportunistic infections in a HIV-negative patient with combined C6 and NFKB1 mutations: A case report, pedigree analysis, and literature review
  205. Letter to the Editor
  206. Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
  207. Erratum
  208. Erratum to “Bladder-embedded ectopic intrauterine device with calculus”
  209. Retraction
  210. Retraction of “XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis”
  211. Corrigendum
  212. Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”
  213. Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
  214. Special Issue The evolving saga of RNAs from bench to bedside - Part II
  215. Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma
  216. Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
  217. Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment
  218. Special Issue Advancements in oncology: bridging clinical and experimental research - Part I
  219. Ultrasound-guided transperineal vs transrectal prostate biopsy: A meta-analysis of diagnostic accuracy and complication rates
  220. Assessment of diagnostic value of unilateral systematic biopsy combined with targeted biopsy in detecting clinically significant prostate cancer
  221. SENP7 inhibits glioblastoma metastasis and invasion by dissociating SUMO2/3 binding to specific target proteins
  222. MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
  223. Analysis of postoperative complications in bladder cancer patients
  224. Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study
  225. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part I
  226. Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma
  227. Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer
  228. Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis
https://doi.org/10.1515/med-2024-1046
Keywords for this article
ureteroscopic holmium laser lithotripsy; nasopharyngeal airway; laryngeal mask; intravenous general anesthesia
Creative Commons
BY 4.0

Articles in the same Issue

  1. Research Articles
  2. EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway
  3. STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
  4. Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
  5. The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma
  6. METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
  7. Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
  8. Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty
  9. Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
  10. Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma
  11. Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue
  12. Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
  13. Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease
  14. METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients
  15. Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis
  16. Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay
  17. Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity
  18. Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound
  19. Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement
  20. miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization
  21. The analyses of human MCPH1 DNA repair machinery and genetic variations
  22. Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
  23. Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma
  24. Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
  25. The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
  26. Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis
  27. Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
  28. Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer
  29. Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke
  30. The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
  31. Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study
  32. Lactate dehydrogenase to albumin ratio is associated with in-hospital mortality in patients with acute heart failure: Data from the MIMIC-III database
  33. CD36-mediated podocyte lipotoxicity promotes foot process effacement
  34. Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
  35. FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
  36. Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
  37. Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
  38. Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition
  39. Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy
  40. Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction
  41. High SEC61A1 expression predicts poor outcome of acute myeloid leukemia
  42. Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
  43. Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway
  44. Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
  45. Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
  46. Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
  47. Clinical analysis of incomplete rupture of the uterus secondary to previous cesarean section
  48. Abnormal sleep duration is associated with sarcopenia in older Chinese people: A large retrospective cross-sectional study
  49. No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study
  50. Identification and validation of autophagy-related genes in SSc
  51. Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming
  52. Evaluation of quality of life in patients with schizophrenia: An inpatient social welfare institution-based cross-sectional study
  53. The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
  54. Compilation of a self-management assessment scale for postoperative patients with aortic dissection
  55. Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
  56. Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
  57. Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2
  58. Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
  59. High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression
  60. Factors influencing cardiovascular system-related post-COVID-19 sequelae: A single-center cohort study
  61. HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis
  62. Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
  63. Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
  64. ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
  65. Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
  66. The role of enhanced expression of Cx43 in patients with ulcerative colitis
  67. Choosing a COVID-19 vaccination site might be driven by anxiety and body vigilance
  68. Role of ICAM-1 in triple-negative breast cancer
  69. Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
  70. HLA-DRB5 promotes immune thrombocytopenia via activating CD8+ T cells
  71. Efficacy and factors of myofascial release therapy combined with electrical and magnetic stimulation in the treatment of chronic pelvic pain syndrome
  72. Efficacy of tacrolimus monotherapy in primary membranous nephropathy
  73. Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking
  74. FBXO45 levels regulated ferroptosis renal tubular epithelial cells in a model of diabetic nephropathy by PLK1
  75. Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns
  76. Alpha-lipoic acid upregulates the PPARγ/NRF2/GPX4 signal pathway to inhibit ferroptosis in the pathogenesis of unexplained recurrent pregnancy loss
  77. Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study
  78. CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway
  79. miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
  80. Immune response analysis of solid organ transplantation recipients inoculated with inactivated COVID-19 vaccine: A retrospective analysis
  81. The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
  82. Clinical efficacy of dexamethasone combined with isoniazid in the treatment of tuberculous meningitis and its effect on peripheral blood T cell subsets
  83. Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis
  84. Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
  85. Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL2
  86. Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
  87. Risk factors of postoperative airway obstruction complications in children with oral floor mass
  88. Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction
  89. Physical activity and mental health trends in Korean adolescents: Analyzing the impact of the COVID-19 pandemic from 2018 to 2022
  90. Evaluating anemia in HIV-infected patients using chest CT
  91. Ponticulus posticus and skeletal malocclusion: A pilot study in a Southern Italian pre-orthodontic court
  92. Causal association of circulating immune cells and lymphoma: A Mendelian randomization study
  93. Assessment of the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals on treating renal fibrosis: A systematic review and meta-analysis
  94. Comprehensive landscape of integrator complex subunits and their association with prognosis and tumor microenvironment in gastric cancer
  95. New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: A drug Mendelian randomization study
  96. Population pharmacokinetics of meropenem in critically ill patients
  97. Comparison of the ability of newly inflammatory markers to predict complicated appendicitis
  98. Comparative morphology of the cruciate ligaments: A radiological study
  99. Immune landscape of hepatocellular carcinoma: The central role of TP53-inducible glycolysis and apoptosis regulator
  100. Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study
  101. SHP-1 mediates cigarette smoke extract-induced epithelial–mesenchymal transformation and inflammation in 16HBE cells
  102. Acute hyper-hypoxia accelerates the development of depression in mice via the IL-6/PGC1α/MFN2 signaling pathway
  103. The GJB3 correlates with the prognosis, immune cell infiltration, and therapeutic responses in lung adenocarcinoma
  104. Physical fitness and blood parameters outcomes of breast cancer survivor in a low-intensity circuit resistance exercise program
  105. Exploring anesthetic-induced gene expression changes and immune cell dynamics in atrial tissue post-coronary artery bypass graft surgery
  106. Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
  107. Analysis of the risk factors of the radiation-induced encephalopathy in nasopharyngeal carcinoma: A retrospective cohort study
  108. Reproductive outcomes in women with BRCA 1/2 germline mutations: A retrospective observational study and literature review
  109. Evaluation of upper airway ultrasonographic measurements in predicting difficult intubation: A cross-section of the Turkish population
  110. Prognostic and diagnostic value of circulating IGFBP2 in pancreatic cancer
  111. Postural stability after operative reconstruction of the AFTL in chronic ankle instability comparing three different surgical techniques
  112. Research trends related to emergence agitation in the post-anaesthesia care unit from 2001 to 2023: A bibliometric analysis
  113. Frequency and clinicopathological correlation of gastrointestinal polyps: A six-year single center experience
  114. ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
  115. Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
  116. Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
  117. The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae
  118. Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
  119. Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study
  120. Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway
  121. Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population
  122. Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
  123. Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study
  124. Decreased BIRC5-206 promotes epithelial–mesenchymal transition in nasopharyngeal carcinoma through sponging miR-145-5p
  125. Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
  126. Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis
  127. Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures
  128. The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial
  129. Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
  130. Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
  131. Parental control attitudes over their pre-school children’s diet
  132. The role of auto-HSCT in extranodal natural killer/T cell lymphoma
  133. Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy
  134. Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin
  135. ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
  136. The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study
  137. The unusual location of primary hydatid cyst: A case series study
  138. Intraoperative changes in electrophysiological monitoring can be used to predict clinical outcomes in patients with spinal cavernous malformation
  139. Obesity and risk of placenta accreta spectrum: A meta-analysis
  140. Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
  141. NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages
  142. The effect of COVID-19 lockdown on admission rates in Maternity Hospital
  143. Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
  144. Luteolin alleviates cerebral ischemia/reperfusion injury by regulating cell pyroptosis
  145. Therapeutic role of respiratory exercise in patients with tuberculous pleurisy
  146. Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
  147. Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
  148. DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy
  149. Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients
  150. Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
  151. Ferroptosis-related prognostic model of mantle cell lymphoma
  152. Observation of choking reaction and other related indexes in elderly painless fiberoptic bronchoscopy with transnasal high-flow humidification oxygen therapy
  153. A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022
  154. The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study
  155. Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
  156. Role of COX6C and NDUFB3 in septic shock and stroke
  157. Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
  158. Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
  159. Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation
  160. Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
  161. Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients
  162. Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
  163. Risk factors for progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fracture
  164. Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke
  165. The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
  166. Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
  167. Detection of serum FOXM1 and IGF2 in patients with ARDS and their correlation with disease and prognosis
  168. Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
  169. Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
  170. Review Articles
  171. Cutaneous signs of selected cardiovascular disorders: A narrative review
  172. XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
  173. A narrative review on adverse drug reactions of COVID-19 treatments on the kidney
  174. Emerging role and function of SPDL1 in human health and diseases
  175. Adverse reactions of piperacillin: A literature review of case reports
  176. Molecular mechanism and intervention measures of microvascular complications in diabetes
  177. Regulation of mesenchymal stem cell differentiation by autophagy
  178. Molecular landscape of borderline ovarian tumours: A systematic review
  179. Advances in synthetic lethality modalities for glioblastoma multiforme
  180. Investigating hormesis, aging, and neurodegeneration: From bench to clinics
  181. Frankincense: A neuronutrient to approach Parkinson’s disease treatment
  182. Sox9: A potential regulator of cancer stem cells in osteosarcoma
  183. Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients
  184. Advanced neuroimaging and criminal interrogation in lie detection
  185. Maternal factors for neural tube defects in offspring: An umbrella review
  186. The chemoprotective hormetic effects of rosmarinic acid
  187. CBD’s potential impact on Parkinson’s disease: An updated overview
  188. Progress in cytokine research for ARDS: A comprehensive review
  189. Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
  190. NRXN1-related disorders, attempt to better define clinical assessment
  191. Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
  192. Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
  193. Iron in ventricular remodeling and aneurysms post-myocardial infarction
  194. Case Reports
  195. Sirolimus potentiated angioedema: A case report and review of the literature
  196. Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report
  197. Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman’s disease: A case report
  198. Complete heart block associated with hepatitis A infection in a female child with fatal outcome
  199. Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review
  200. Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
  201. Advancing prenatal diagnosis: Echocardiographic detection of Scimitar syndrome in China – A case series
  202. Outcomes and complications of hemodialysis in patients with renal cancer following bilateral nephrectomy
  203. Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy
  204. Recurrent opportunistic infections in a HIV-negative patient with combined C6 and NFKB1 mutations: A case report, pedigree analysis, and literature review
  205. Letter to the Editor
  206. Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
  207. Erratum
  208. Erratum to “Bladder-embedded ectopic intrauterine device with calculus”
  209. Retraction
  210. Retraction of “XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis”
  211. Corrigendum
  212. Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”
  213. Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
  214. Special Issue The evolving saga of RNAs from bench to bedside - Part II
  215. Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma
  216. Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
  217. Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment
  218. Special Issue Advancements in oncology: bridging clinical and experimental research - Part I
  219. Ultrasound-guided transperineal vs transrectal prostate biopsy: A meta-analysis of diagnostic accuracy and complication rates
  220. Assessment of diagnostic value of unilateral systematic biopsy combined with targeted biopsy in detecting clinically significant prostate cancer
  221. SENP7 inhibits glioblastoma metastasis and invasion by dissociating SUMO2/3 binding to specific target proteins
  222. MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
  223. Analysis of postoperative complications in bladder cancer patients
  224. Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study
  225. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part I
  226. Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma
  227. Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer
  228. Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis
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