Startseite Medizin Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
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Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review

  • Kevin J. Yang EMAIL logo und Porus D. Mistry
Veröffentlicht/Copyright: 3. Dezember 2024
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Aus der Zeitschrift Open Medicine Band 19 Heft 1

Abstract

Introduction

Complex regional pain syndrome (CRPS) is a chronic pain condition most often triggered by direct injury to an extremity that is characterized by disproportionate pain, sensory abnormalities, and autonomic dysfunction. Early research into intravenous lidocaine therapy for CRPS has demonstrated promise, but clinical evidence remains scarce. We report on 12 patients with chronic CRPS who underwent intravenous lidocaine therapy and discuss our findings in the context of the existing literature.

Results

Patients ages ranged from 25 to 64 years. Duration of CRPS ranged from 4 to 25 years. The majority of patients (8/12, 67%) reported adequate subjective pain relief with intravenous lidocaine therapy, whereas four patients reported inadequate subjective pain relief with therapy. All patients were being treated with at least one other pharmacotherapy. Three patients experienced minor side effects.

Conclusions

Our cases, taken with existing evidence, suggest that intravenous lidocaine for the treatment of chronic CRPS is safe and may decrease the pain associated with chronic CRPS. However, this study lacks adequate sample size to make those conclusions confidently. We recommend a randomized placebo-controlled multicenter clinical trial to establish the efficacy and side effect profile of systemic intravenous lidocaine more confidently for the treatment of pain due to chronic CRPS.

Keywords: causalgia; chronic pain; complex regional pain syndrome; lidocaine; neuropathic pain; reflex sympathetic dystrophy

1 Introduction

Complex regional pain syndrome (CRPS) is a chronic pain condition characterized by disproportionate pain, sensory abnormalities, and autonomic dysfunction. CRPS is most often triggered by direct injury to an extremity, including trauma and surgery. The pathophysiology of CRPS is thought to result from the interplay of neuroinflammatory, vascular, and central nervous system (CNS) mechanisms. Dysregulation of the sympathetic nervous system, neurogenic inflammation, and maladaptive plasticity in the CNS contribute to the perpetuation of pain and sensory symptoms observed in CRPS [1]. Many CRPS patients present with the acute form, which often self-resolves within a year of inciting injury. However, some patients will progress to the chronic form, in which patients suffer from long-term debilitating pain [1].

CRPS is classified into two subtypes: Type I, formerly known as reflex sympathetic dystrophy and Type II, previously termed causalgia. Type I CRPS occurs without identifiable nerve injury, whereas Type II CRPS is associated with confirmed nerve damage [1]. Both types manifest with similar clinical features, including severe pain, edema, changes in skin temperature, and motor dysfunction. To aid in diagnosis of CRPS, the Budapest criteria, established by the International Association for the Study of Pain, provides a standardized framework encompassing clinical signs and symptoms characteristic of CRPS [2].

While various treatment modalities exist for chronic CRPS management, ranging from physical therapy to pharmacotherapy and interventional procedures, a significant proportion of patients experience inadequate pain relief or intolerable side effects [3]. For refractory cases, therapeutic options are limited, emphasizing the urgent need for novel therapies.

Preclinical studies have demonstrated promising results regarding the efficacy of intravenous lidocaine infusion in alleviating CRPS-related pain and symptoms. Those studies uncovered that, subsequent to injury of peripheral nerves, there is an augmentation in tetrodotoxin-resistant sodium channels within primary nociceptive afferent fibers alongside minute dorsal root ganglia neurons involved in pain transmission, resulting in notable physiological alterations [4–6]. The infusion of lidocaine intravenously obstructs these particular channels, hindering repetitive depolarization in a manner contingent upon usage [7].

Those findings have prompted further exploration of lidocaine as a potential therapeutic agent in human subjects. Prior randomized placebo-controlled trial of intravenous lidocaine to treat neuropathic pain (5 mg/kg/h over 6 h) demonstrated 4 h pain relief after cessation of the infusion without causing adverse side effects [8]. A prior retrospective review of 49 patients who underwent intravenous lidocaine (titrated to a lidocaine blood concentration of 5 mg/L of blood delivered daily over the course of 5 days) for treatment of chronic, refractory CRPS demonstrated a significant decrease in mechanical and thermal allodynia for 3 months, lessened associated inflammatory components of CRPS, minimal side effects, and no severe complications [9].

Clinical evidence supporting the use of lidocaine infusion in CRPS management remains scarce. As such, we aim to add to the body of evidence evaluating the effectiveness of lidocaine infusion as a therapy for the treatment of CRPS. We present a case series of patients who underwent systemic intravenous lidocaine infusion for the treatment of chronic CRPS and report on whether each patient experienced subjective pain relief. We then report on our literature review of intravenous lidocaine for the treatment of chronic CRPS and discuss our findings in the context of the existing literature.

2 Methods

2.1 Chart review

This study was a retrospective chart review. A list of all past and present patients who were treated with intravenous lidocaine at the University of Southern California (USC) Pain Center’s associated intravenous infusion center was obtained. The medical indication for each of these patient’s intravenous lidocaine therapy were found by reviewing each patient’s electronic medical records. Those patients whose indication for intravenous lidocaine therapy was CRPS were included in the study.

For those patients included in the study, whether or not the patient’s follow-up visit records included a qualitative description of positive response to lidocaine infusion was recorded; this parameter was used as our measure of subjective adequate pain relief. Other data collected are presented in Section 3. Inclusion was limited to patients who met the Budapest criteria for CRPS. This study was reviewed and determined to be exempt §46.104(d) (4) on 4 March 2024 by the USC Institutional Review Board. This study was performed in accordance with CARE guidelines. All patient details have been de-identified.

2.2 Patient treatment

All patients first underwent electrocardiogram, complete metabolic panel, and magnesium level testing prior to initiation of lidocaine infusion therapy. During their first infusion session, all patients were started on a lidocaine infusion dose of 2 mg/kg/h, administered over 4 h. If tolerated, the dosage was increased to a goal of 4 mg/kg/h the following day. All subsequent infusion sessions were 4 h in duration. Subsequent infusions were repeated on a schedule of two consecutive days of infusion per month at the tolerated dose. During all infusion sessions, patients were continuously monitored by infusion unit nurses with a physician immediately available at all times. All patients were provided standard of care treatment, had full information regarding expected benefits and possible complications of intravenous lidocaine therapy. All patients gave informed consent to treatment.

2.3 Literature review

A comprehensive literature review was conducted to identify relevant studies on the use of intravenous lidocaine for the treatment of CRPS. The search was performed exclusively using the PubMed database (https://pubmed.ncbi.nlm.nih.gov/). The search strategy aimed to capture all studies evaluating IV lidocaine in the context of CRPS management. The following search query was used to retrieve relevant articles: (“lidocaine”[Title/Abstract] OR “intravenous lidocaine”[Title/Abstract]) AND (“complex regional pain syndrome”[Title/Abstract] OR “CRPS”[Title/Abstract]). This query was designed to include both key terms for lidocaine and CRPS, accounting for potential variations in terminology. No filters were applied to limit publication date or study type to ensure a broad inclusion of available literature. Articles identified through the search were screened based on their relevance to the topic, and studies specifically investigating the use of intravenous lidocaine for treating CRPS were selected for inclusion in the review.

3 Results

We found a total of 12 patients being treated for CRPS by intravenous lidocaine infusion. Patient ages ranged from late 20s to 60s. Nine of our patients were female and three were male. Duration of CRPS ranged from 4 to 25 years. Eight patients reported adequate subjective pain relief with intravenous lidocaine therapy, whereas four patients reported inadequate subjective pain relief with therapy. Three patients experienced minor side effects. One patient experienced perioral numbness at infusion rate of 4 mg/kg/h, which resolved on reduction of the infusion rate to 3 mg/kg/h. One patient experienced mental fogginess when their infusion rate was increased from 2 to 4 mg/kg/h, which resolved on reduction of the infusion rate to 3 mg/kg/h. One patient experienced dizziness during one infusion session, which self-resolved over the course of the infusion. Patient demographics, details about patient CRPS condition, details about patient lidocaine infusion therapy parameters, response to therapy, and complications associated with therapy are reported in Table 1. Our data revealed no clear relationship between number of infusions, lidocaine dosage, CRPS duration, and adequate pain relief.

Table 1

Patient demographics, details about CRPS condition, details about lidocaine infusion, response to lidocaine infusion, and complications of therapy

Patient number Age Sex Site of pain Duration of CRPS (years) Number of infusions Initial lidocaine dose (mg/kg/h) Most recent lidocaine dose (mg/kg/h) Adequate subjective pain relief? If inadequate pain relief, change made Complications
1 Late 40s F RUE, BLE 25 16 2 4 No Added IV ketamine infusions
2 Late 30s F RUE 5 5 2 4 Yes
3 Late 30s F RUE, LUE 11 42 2 4 Yes
4 Late 50s F RLE 20 10 2 4 No Stopped lidocaine infusion
5 Early 50s F RUE, BLE 14 19 2 4 Yes
6 Early 40s F LLE Unknown 5 2 4 Yes
7 Late 20s F RUE 4 3 2 3 Yes
8 Early 60s F Bilateral feet 7 25 2 3 Yes Patient experienced perioral numbness at infusion rate of 4 mg/kg/h. Resolved on reduction of infusion rate to 3 mg/kg/h
9 Early 60s F Left knee 9 3 2 3 Yes Patient experienced mental fogginess when uptitrated from 2 to 4 mg/kg/h. Subsequently reduced to 3 mg/kg/h
10 Late 50s M LLE 16 6 2 4 Yes
11 Late 20s M LLE 7 4 2 4 No Stopped lidocaine infusion Dizziness (resolved during infusion)
12 Early 50s M BLE 9 2 2 4.75 No Stopped lidocaine infusion

Note: F = female, M = male, RUE = right upper extremity, RLE = right lower extremity, BLE = bilateral lower extremities, LUE = left upper extremity, LLE = left lower extremity, BUE = bilateral upper extremities, IV = intravenous, mg/kg/h = milligrams of lidocaine per patient’s weight in kilograms per hour of infusion.

All patients were being treated with at least one other pharmacotherapy for the management of CRPS-related pain at the time of initiating lidocaine infusion therapy. The additional pharmacotherapy of each patient is reported in Table 2.

Table 2

Additional pharmacotherapy for pain of each patient at time of lidocaine infusion therapy

Patient number NSAID Antidepressants Anticonvulsants Spasmolytics Opioids Oral ketamine Transdermal ketamine Intramuscular ketamine IV Ketamine Benzodiazepines Transdermal lidocaine (patch)
1 Yes Yes Yes Yes Yes
2 Yes Yes Yes Yes Yes Yes
3 Yes Yes Yes Yes
4 Yes Yes Yes Yes Yes Yes Yes
5 Yes Yes Yes Yes Yes
6 Yes Yes Yes
7 Yes
8 Yes Yes Yes Yes Yes Yes Yes Yes
9 Yes Yes Yes Yes
10 Yes Yes
11 Yes
12 Yes Yes

Note: NSAID = non-steroidal anti-inflammatory drug, IV = intravenous.

4 Discussion

We report on 12 patients who underwent systemic intravenous lidocaine infusion for the treatment of chronic CRPS. Of our patients, the majority of them (8/12, or 67%) experienced clinically significant reduction in pain symptoms. While our sample size is not large enough to demonstrate a meaningful correlation between intravenous lidocaine therapy and pain relief, our pain relief findings are consistent with the two other currently published studies investigating the efficacy of systemic intravenous lidocaine for the treatment of CRPS.

Schwartzman et al. investigated the efficacy of systemic intravenous lidocaine titrated to lidocaine blood concentration of 5 mg/L of blood delivered daily over the course of 5 days for the treatment of chronic CRPS with a sample size of 49 patients [9]. Schwartzman et al. found improvement in dynamic and static mechano-allodynia, deep muscle pain, joint pain, and thermal allodynia (cold stimulus) in all patients at 3 months following infusion, with return to baseline by 6 months following infusion. Their study reports that the most profound improvement was on thermal and mechanical allodynia. They also reported a statistically significant but a much less robust improvement of movement symptoms of CRPS, including weakness, spasms, dystonia, and tremor.

Wallace et al. also investigated the efficacy of systemic intravenous lidocaine for the treatment of pain associated with CRPS Types I and II [10]. In their randomized, double-blind, placebo-controlled, crossover study, 16 patients received a systemic infusion of lidocaine. Spontaneous and evoked pain scores and neurosensory testing within the painful area were measured when patient plasma levels of lidocaine reached 1, 2, and 3 μm/mL of lidocaine and were compared to baseline measurements. All patients also underwent the same testing while undergoing intravenous diphenhydramine infusion (separated from lidocaine therapy by a washout period of 1 week) as a control. The authors found that lidocaine infusion caused a significant elevation of the hot pain thresholds in the affected area. Furthermore, the authors found a significant decrease in hyperalgesia when patients receiving lidocaine were stroked with a cotton wisp or exposed to cold. While this study reports statistically significant pain improvement in multiple forms, it fails to evaluate response to therapy for any significant amount of time following treatment, limiting the clinical significance of the authors’ findings.

The only other study uncovered by our literature search reporting on pain relief from systemic intravenous lidocaine in CRPS patients was a case report by Rickard and Kish [11]. These authors report on a patient with CRPS who underwent three intravenous lidocaine infusions in an intensive care unit setting, each providing significant pain relief. During the first admission, the patient received 1 mg/kg/h over 4 h. During the second admission, the patient underwent infusion at a rate of 1.5 mg/kg/h for 4 h, followed by a third infusion 3 days later at 2 mg/kg/h for 4 h.

Three patients in this study experienced minor adverse effects. One patient experienced perioral numbness, which resolved on reduction of the infusion rate from 4 to 3 mg/kg/h. One patient experienced mental fogginess when their infusion rate was increased from 2 to 4 mg/kg/h, which resolved on reduction of the infusion rate to 3 mg/kg/h. One patient experienced self-resolving dizziness during one infusion session. As such, the side effects reported by patients in this study were mild and temporary in nature. Of the side effects noted by Wallace et al. in their study, only light headedness was significantly higher in the lidocaine treatment group compared to the control group. It is possible that the “mental fogginess” and “dizziness” described by two of our patients is the same phenomenon as the “light-headedness” experienced by the Wallace et al. patients. Schwartzman et al. reported complications in 16 patients, all of which did not persist beyond 12 h after cessation of treatment. Most were mild and included, nausea, fatigue, mild cardiac side effects, mild neurological side effects, and mild psychiatric side effects. One patient experienced seizure. Of note, none of the complications reported by our patients were reported by Schwartzman et al. That fact, alongside the variety of complications reported by Schwartzman et al., suggest that complications of intravenous lidocaine therapy have widely variable presentations. All currently reported complications of lidocaine infusion therapy were benign.

All the patients included in this study were being treated with other medications at the time of initiating systemic intravenous lidocaine therapy. Concurrent treatment with various agents can theoretically complicate the use of systemic IV lidocaine in treating CRPS. Seven patients were being treated with antidepressants; tricyclic antidepressants in particular are known to increase the risk of cardiac arrythmias, which may potentially compound the cardiac side effects of intravenous lidocaine. Five patients were treated with spasmolytics, including tizanidine, which has hypotensive effects that could be exacerbated by lidocaine’s vasodilatory properties. The potential for those effects emphasizes the importance of cardiac monitoring during lidocaine infusion sessions. Spasmolytics, in addition to anticonvulsants, opioids, and benzodiazepine medications are known to have sedative and CNS depressive effects, which could be compounded by the sedative effect of intravenous lidocaine infusion. Those potential interactions suggest that CNS monitoring in such patients may be appropriate. It is important to note that such interactions are theoretical and merit further study.

Other forms of lidocaine administration for the treatment of CRPS-related pain have also been investigated. Several studies have examined using intravenous regional anesthesia (IVRA, also referred to as Bier block) techniques to administer lidocaine in solution with other agents for the treatment of CRPS in a specific extremity. Varitimidis et al. studied 168 patients with CRPS Type I of the upper extremity using a Bier block with 25 mL of 0.5% lidocaine and 125 mg of methylprednisolone, reporting significant improvements in pain relief, grip strength, and total active motion after an average of 4.8 sessions [12]. In a comparative study by Nascimento et al., IVRA using lidocaine and clonidine were shown to be as effective as sympathetic ganglion blocks for pain management in CRPS, though IVRA had fewer side effects and was easier to perform [13]. Eckmann et al. investigated the use of ketorolac and lidocaine for IVRA in patients with lower extremity CRPS, finding only short-term pain reduction, with pain typically returning within a week [14].

Topical lidocaine for CRPS pain management has also been explored. In a randomized placebo-controlled trial by Fallico et al., 150 patients were divided into three groups: lidocaine injections with oral citalopram, lidocaine injections with oral placebo, and placebo injections with oral placebo [15]. The combined treatment of lidocaine and citalopram significantly improved impairment sum scores (ISS) from 47.6 to 12.6, compared to lidocaine alone (ISS 47.5–21.5) and placebo (ISS 47.2–29.9), showing greater efficacy of the combined treatment over both placebo treatments. Additionally, a case report by Hanlan et al. described a patient with CRPS of the right upper extremity who experienced significant pain relief from topical lidocaine 5%, which allowed her to engage in physical therapy and improved her hand’s swelling and appearance over the course of her rehabilitation [16].

The reason why systemic intravenous lidocaine may be effective as therapy for CRPS may lie in lidocaine’s potential to modulate pain signaling pathways and suppress abnormal sensory processing. Lidocaine’s well-established efficacy as a local anesthetic results from the drug’s sodium channel-blocking activity, which transmit pain signals along the nerves. By inhibiting sodium channels, lidocaine dampens the transmission of pain signals from the affected area to the brain. Lidocaine has also been shown to block N-methyl-d-aspartate receptors [17], which contribute to the development and maintenance of chronic pain. By antagonizing these receptors, lidocaine may help reduce the hypersensitivity and central sensitization associated with CRPS.

Chronic inflammation has also been implicated in the pathophysiology of CRPS. The concentrations of proinflammatory cytokines, such as interleukin-1 (IL-1), IL-6, IL-8, and tumor necrosis factor (TNF)-α are elevated in the serum, cerebrospinal fluid, and skin blister fluid of CRPS patients [18]. Conversely, levels of anti-inflammatory cytokines such as IL-4, IL-10, and transforming growth factor-β are reduced in the serum of those patients [18]. Lidocaine has been shown to possess anti-inflammatory properties [19]. Specifically, lidocaine has been associated with a significant reduction in the following pro-inflammatory markers: TNF-α, IL-1RA, IL-8, IL-17, high mobility group box-1, and c-reactive protein [20]. As such, lidocaine may act by inhibiting the release of certain pro-inflammatory mediators associated with CRPS from immune cells and reducing the recruitment of inflammatory cells to the site of injury, thus reducing CRPS-related symptoms.

Furthermore, intravenous lidocaine has been reported to modulate sympathetic activity, possibly by blocking sympathetic ganglia or by modulating neurotransmitter release [21]. CRPS is characterized by dysregulation of the sympathetic nervous system, leading to abnormal vasoconstriction and other autonomic disturbances [22]. Thus, by blocking sympathetic ganglia or by modulating neurotransmitter release, intravenous lidocaine may alleviate the symptoms associated with sympathetic dysfunction in CRPS.

Lidocaine has also been shown to exert neuromodulatory effects on various neuronal circuits involved in pain processing [23]. By altering neuronal excitability and synaptic transmission, lidocaine may help normalize aberrant neural activity associated with chronic pain conditions like CRPS.

This case series, alongside the accompanying literature review, suggests that systemic intravenous lidocaine for the treatment of chronic CRPS is safe and may decrease the pain associated with chronic CRPS. However, this study lacks adequate sample size to make those conclusions confidently. High potential for bias and confounding factors in our dataset further limit the generalizability of this study. Given the present paucity of data in the existing literature, we recommend a randomized placebo-controlled multicenter clinical trial to establish the efficacy, duration of relief, and side effect profile of intravenous lidocaine more confidently for the treatment of pain due to chronic CRPS. Studies comparing the efficacy of systemic intravenous lidocaine to lidocaine administered by IVRA and topical lidocaine for the management of CRPS-related pain are also merited.

Acknowledgements

The authors report no acknowledgements.

  1. Funding information: Authors report no sources of funding.

  2. Author contributions: K.J.Y. contributed to conceptualization, project administration. writing of the original draft, and review and editing of subsequent drafts. P.D.M. contributed to conceptualization, review and editing of drafts, and supervision.

  3. Conflict of interest: Authors report no conflicts of interest.

  4. Data availability statement: Full data are already available with publication.

References

[1] Bruehl S. Complex regional pain syndrome. BMJ. 2015;351:h2730. Epub 20150729. 10.1136/bmj.h2730. PubMed PMID: 26224572.Suche in Google Scholar PubMed

[2] Harden NR, Bruehl S, Perez RS, Birklein F, Marinus J, Maihofner C, et al. Validation of proposed diagnostic criteria (the “Budapest Criteria”) for complex regional pain syndrome. Pain. 2010;150(2):268–74. Epub 20100520. 10.1016/j.pain.2010.04.030. PubMed PMID: 20493633; PubMed Central PMCID: PMC2914601.Suche in Google Scholar PubMed PubMed Central

[3] Harden RN, McCabe CS, Goebel A, Massey M, Suvar T, Grieve S, et al. Complex regional pain syndrome: practical diagnostic and treatment guidelines. Pain Med. 2022;23(Suppl 1):S1–53. 10.1093/pm/pnac046. PubMed PMID: 35687369; PubMed Central PMCID: PMC9186375.Suche in Google Scholar PubMed PubMed Central

[4] Rabert DK, Koch BD, Ilnicka M, Obernolte RA, Naylor SL, Herman RC, et al. A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A. Pain. 1998;78(2):107–14. 10.1016/S0304-3959(98)00120-1. PubMed PMID: 9839820.Suche in Google Scholar PubMed

[5] Tanaka M, Cummins TR, Ishikawa K, Dib-Hajj SD, Black JA, Waxman SG. SNS Na+ channel expression increases in dorsal root ganglion neurons in the carrageenan inflammatory pain model. Neuroreport. 1998;9(6):967–72. 10.1097/00001756-199804200-00003. PubMed PMID: 9601651.Suche in Google Scholar PubMed

[6] Lai J, Hunter JC, Porreca F. The role of voltage-gated sodium channels in neuropathic pain. Curr Opin Neurobiol. 2003;13(3):291–7. 10.1016/s0959-4388(03)00074-6. PubMed PMID: 12850213.Suche in Google Scholar PubMed

[7] Leffler A, Reiprich A, Mohapatra DP, Nau C. Use-dependent block by lidocaine but not amitriptyline is more pronounced in tetrodotoxin (TTX)-resistant Nav1.8 than in TTX-sensitive Na+ channels. J Pharmacol Exp Ther. 2007;320(1):354–64. PubMed PMID: 17005919. 10.1124/jpet.106.109025. Epub 20060927.Suche in Google Scholar PubMed

[8] Tremont-Lukats IW, Hutson PR, Backonja MM. A randomized, double-masked, placebo-controlled pilot trial of extended IV lidocaine infusion for relief of ongoing neuropathic pain. Clin J Pain. 2006;22(3):266–71. 10.1097/01.ajp.0000169673.57062.40. PubMed PMID: 16514327.Suche in Google Scholar PubMed

[9] Schwartzman RJ, Patel M, Grothusen JR, Alexander GM. Efficacy of 5-day continuous lidocaine infusion for the treatment of refractory complex regional pain syndrome. Pain Med. 2009;10(2):401–12. 10.1111/j.1526-4637.2009.00573.x. PubMed PMID: 19284488.Suche in Google Scholar PubMed

[10] Wallace MS, Ridgeway BM, Leung AY, Gerayli A, Yaksh TL. Concentration–effect relationship of intravenous lidocaine on the allodynia of complex regional pain syndrome types I and II. Anesthesiology. 2000;92(1):75–83. 10.1097/00000542-200001000-00017. PubMed PMID: 10638902.Suche in Google Scholar PubMed

[11] Rickard JP, Kish T. Systemic intravenous lidocaine for the treatment of complex regional pain syndrome: a case report and literature review. Am J Ther. 2016;23(5):e1266–9. 10.1097/MJT.0000000000000345. PubMed PMID: 26398854.Suche in Google Scholar PubMed

[12] Varitimidis SE, Papatheodorou LK, Dailiana ZH, Poultsides L, Malizos KN. Complex regional pain syndrome type I as a consequence of trauma or surgery to upper extremity: management with intravenous regional anaesthesia, using lidocaine and methyloprednisolone. J Hand Surg Eur Vol. 2011;36(9):771–7. Epub 20110630. 10.1177/1753193411413852. PubMed PMID: 21719518.Suche in Google Scholar PubMed

[13] Nascimento MS, Klamt JG, Prado WA. Intravenous regional block is similar to sympathetic ganglion block for pain management in patients with complex regional pain syndrome type I. Braz J Med Biol Res. 2010;43(12):1239–44. Epub 20101112. 10.1590/s0100-879x2010007500123. PubMed PMID: 21085893.Suche in Google Scholar PubMed

[14] Eckmann MS, Ramamurthy S, Griffin JG. Intravenous regional ketorolac and lidocaine in the treatment of complex regional pain syndrome of the lower extremity: a randomized, double-blinded, crossover study. Clin J Pain. 2011;27(3):203–6. 10.1097/AJP.0b013e3181fd5150. PubMed PMID: 21358290.Suche in Google Scholar PubMed

[15] Fallico N, Padmanabhan R, Rahman S, Somma F, Spagnoli AM. A randomised placebo-controlled clinical trial on the efficacy of local lidocaine injections and oral citalopram for the treatment of complex regional pain syndrome. J Plast Reconstr Aesthet Surg. 2022;75(3):970–9. Epub 20211114. 10.1016/j.bjps.2021.11.022. PubMed PMID: 34903493.Suche in Google Scholar PubMed

[16] Hanlan AK, Mah-Jones D, Mills PB. Early adjunct treatment with topical lidocaine results in improved pain and function in a patient with complex regional pain syndrome. Pain Physician. 2014;17(5):E629–35. PubMed PMID: 25247913.10.36076/ppj.2014/17/E629Suche in Google Scholar

[17] Yang X, Wei X, Mu Y, Li Q, Liu J. A review of the mechanism of the central analgesic effect of lidocaine. Medicine (Baltimore). 2020;99(17):e19898. 10.1097/MD.0000000000019898. PubMed PMID: 32332666; PubMed Central PMCID: PMC7440315.Suche in Google Scholar PubMed PubMed Central

[18] Wen B, Pan Y, Cheng J, Xu L, Xu J. The role of neuroinflammation in complex regional pain syndrome: a comprehensive review. J Pain Res. 2023;16:3061–73. Epub 20230906. 10.2147/JPR.S423733. PubMed PMID: 37701560; PubMed Central PMCID: PMC10493102.Suche in Google Scholar PubMed PubMed Central

[19] Caracas HC, Maciel JV, Martins PM, de Souza MM, Maia LC. The use of lidocaine as an anti-inflammatory substance: a systematic review. J Dent. 2009;37(2):93–7. Epub 20081205. 10.1016/j.jdent.2008.10.005. PubMed PMID: 19058888.Suche in Google Scholar PubMed

[20] Castro I, Carvalho P, Vale N, Monjardino T, Mourão J. Systemic anti-inflammatory effects of intravenous lidocaine in surgical patients: a systematic review and meta-analysis. J Clin Med. 2023;12(11). Epub 20230531. 10.3390/jcm12113772. PubMed PMID: 37297968; PubMed Central PMCID: PMC10253813.Suche in Google Scholar PubMed PubMed Central

[21] Li X, Chen H, Zhu Y, Li Y, Zhang T, Tang J. Lidocaine reduces pain behaviors by inhibiting the expression of Nav1.7 and Nav1.8 and diminishing sympathetic sprouting in SNI rats. Mol Pain. 2022;18.10.1177/17448069221124925Suche in Google Scholar

[22] Jänig W, Baron R. Complex regional pain syndrome is a disease of the central nervous system. Clin Auton Res. 2002;12(3):150–64. 10.1007/s10286-002-0022-1. PubMed PMID: 12269546.Suche in Google Scholar PubMed

[23] Spagnoli AM, Fino P, Fioramonti P, Corrias F, Lo Torto F, Scuderi N. Neuromodulation in the treatment of hand’s scars. Ann Ital Chir. 2012;83(2):103–7. PubMed PMID: 22462328.Suche in Google Scholar
Received: 2024-05-14
Revised: 2024-09-18
Accepted: 2024-11-07
Published Online: 2024-12-03

© 2024 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  32. Lactate dehydrogenase to albumin ratio is associated with in-hospital mortality in patients with acute heart failure: Data from the MIMIC-III database
  33. CD36-mediated podocyte lipotoxicity promotes foot process effacement
  34. Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
  35. FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
  36. Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
  37. Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
  38. Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition
  39. Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy
  40. Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction
  41. High SEC61A1 expression predicts poor outcome of acute myeloid leukemia
  42. Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
  43. Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway
  44. Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
  45. Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
  46. Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
  47. Clinical analysis of incomplete rupture of the uterus secondary to previous cesarean section
  48. Abnormal sleep duration is associated with sarcopenia in older Chinese people: A large retrospective cross-sectional study
  49. No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study
  50. Identification and validation of autophagy-related genes in SSc
  51. Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming
  52. Evaluation of quality of life in patients with schizophrenia: An inpatient social welfare institution-based cross-sectional study
  53. The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
  54. Compilation of a self-management assessment scale for postoperative patients with aortic dissection
  55. Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
  56. Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
  57. Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2
  58. Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
  59. High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression
  60. Factors influencing cardiovascular system-related post-COVID-19 sequelae: A single-center cohort study
  61. HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis
  62. Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
  63. Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
  64. ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
  65. Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
  66. The role of enhanced expression of Cx43 in patients with ulcerative colitis
  67. Choosing a COVID-19 vaccination site might be driven by anxiety and body vigilance
  68. Role of ICAM-1 in triple-negative breast cancer
  69. Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
  70. HLA-DRB5 promotes immune thrombocytopenia via activating CD8+ T cells
  71. Efficacy and factors of myofascial release therapy combined with electrical and magnetic stimulation in the treatment of chronic pelvic pain syndrome
  72. Efficacy of tacrolimus monotherapy in primary membranous nephropathy
  73. Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking
  74. FBXO45 levels regulated ferroptosis renal tubular epithelial cells in a model of diabetic nephropathy by PLK1
  75. Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns
  76. Alpha-lipoic acid upregulates the PPARγ/NRF2/GPX4 signal pathway to inhibit ferroptosis in the pathogenesis of unexplained recurrent pregnancy loss
  77. Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study
  78. CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway
  79. miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
  80. Immune response analysis of solid organ transplantation recipients inoculated with inactivated COVID-19 vaccine: A retrospective analysis
  81. The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
  82. Clinical efficacy of dexamethasone combined with isoniazid in the treatment of tuberculous meningitis and its effect on peripheral blood T cell subsets
  83. Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis
  84. Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
  85. Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL2
  86. Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
  87. Risk factors of postoperative airway obstruction complications in children with oral floor mass
  88. Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction
  89. Physical activity and mental health trends in Korean adolescents: Analyzing the impact of the COVID-19 pandemic from 2018 to 2022
  90. Evaluating anemia in HIV-infected patients using chest CT
  91. Ponticulus posticus and skeletal malocclusion: A pilot study in a Southern Italian pre-orthodontic court
  92. Causal association of circulating immune cells and lymphoma: A Mendelian randomization study
  93. Assessment of the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals on treating renal fibrosis: A systematic review and meta-analysis
  94. Comprehensive landscape of integrator complex subunits and their association with prognosis and tumor microenvironment in gastric cancer
  95. New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: A drug Mendelian randomization study
  96. Population pharmacokinetics of meropenem in critically ill patients
  97. Comparison of the ability of newly inflammatory markers to predict complicated appendicitis
  98. Comparative morphology of the cruciate ligaments: A radiological study
  99. Immune landscape of hepatocellular carcinoma: The central role of TP53-inducible glycolysis and apoptosis regulator
  100. Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study
  101. SHP-1 mediates cigarette smoke extract-induced epithelial–mesenchymal transformation and inflammation in 16HBE cells
  102. Acute hyper-hypoxia accelerates the development of depression in mice via the IL-6/PGC1α/MFN2 signaling pathway
  103. The GJB3 correlates with the prognosis, immune cell infiltration, and therapeutic responses in lung adenocarcinoma
  104. Physical fitness and blood parameters outcomes of breast cancer survivor in a low-intensity circuit resistance exercise program
  105. Exploring anesthetic-induced gene expression changes and immune cell dynamics in atrial tissue post-coronary artery bypass graft surgery
  106. Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
  107. Analysis of the risk factors of the radiation-induced encephalopathy in nasopharyngeal carcinoma: A retrospective cohort study
  108. Reproductive outcomes in women with BRCA 1/2 germline mutations: A retrospective observational study and literature review
  109. Evaluation of upper airway ultrasonographic measurements in predicting difficult intubation: A cross-section of the Turkish population
  110. Prognostic and diagnostic value of circulating IGFBP2 in pancreatic cancer
  111. Postural stability after operative reconstruction of the AFTL in chronic ankle instability comparing three different surgical techniques
  112. Research trends related to emergence agitation in the post-anaesthesia care unit from 2001 to 2023: A bibliometric analysis
  113. Frequency and clinicopathological correlation of gastrointestinal polyps: A six-year single center experience
  114. ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
  115. Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
  116. Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
  117. The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae
  118. Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
  119. Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study
  120. Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway
  121. Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population
  122. Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
  123. Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study
  124. Decreased BIRC5-206 promotes epithelial–mesenchymal transition in nasopharyngeal carcinoma through sponging miR-145-5p
  125. Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
  126. Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis
  127. Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures
  128. The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial
  129. Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
  130. Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
  131. Parental control attitudes over their pre-school children’s diet
  132. The role of auto-HSCT in extranodal natural killer/T cell lymphoma
  133. Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy
  134. Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin
  135. ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
  136. The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study
  137. The unusual location of primary hydatid cyst: A case series study
  138. Intraoperative changes in electrophysiological monitoring can be used to predict clinical outcomes in patients with spinal cavernous malformation
  139. Obesity and risk of placenta accreta spectrum: A meta-analysis
  140. Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
  141. NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages
  142. The effect of COVID-19 lockdown on admission rates in Maternity Hospital
  143. Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
  144. Luteolin alleviates cerebral ischemia/reperfusion injury by regulating cell pyroptosis
  145. Therapeutic role of respiratory exercise in patients with tuberculous pleurisy
  146. Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
  147. Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
  148. DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy
  149. Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients
  150. Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
  151. Ferroptosis-related prognostic model of mantle cell lymphoma
  152. Observation of choking reaction and other related indexes in elderly painless fiberoptic bronchoscopy with transnasal high-flow humidification oxygen therapy
  153. A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022
  154. The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study
  155. Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
  156. Role of COX6C and NDUFB3 in septic shock and stroke
  157. Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
  158. Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
  159. Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation
  160. Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
  161. Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients
  162. Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
  163. Risk factors for progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fracture
  164. Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke
  165. The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
  166. Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
  167. Detection of serum FOXM1 and IGF2 in patients with ARDS and their correlation with disease and prognosis
  168. Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
  169. Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
  170. Review Articles
  171. Cutaneous signs of selected cardiovascular disorders: A narrative review
  172. XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
  173. A narrative review on adverse drug reactions of COVID-19 treatments on the kidney
  174. Emerging role and function of SPDL1 in human health and diseases
  175. Adverse reactions of piperacillin: A literature review of case reports
  176. Molecular mechanism and intervention measures of microvascular complications in diabetes
  177. Regulation of mesenchymal stem cell differentiation by autophagy
  178. Molecular landscape of borderline ovarian tumours: A systematic review
  179. Advances in synthetic lethality modalities for glioblastoma multiforme
  180. Investigating hormesis, aging, and neurodegeneration: From bench to clinics
  181. Frankincense: A neuronutrient to approach Parkinson’s disease treatment
  182. Sox9: A potential regulator of cancer stem cells in osteosarcoma
  183. Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients
  184. Advanced neuroimaging and criminal interrogation in lie detection
  185. Maternal factors for neural tube defects in offspring: An umbrella review
  186. The chemoprotective hormetic effects of rosmarinic acid
  187. CBD’s potential impact on Parkinson’s disease: An updated overview
  188. Progress in cytokine research for ARDS: A comprehensive review
  189. Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
  190. NRXN1-related disorders, attempt to better define clinical assessment
  191. Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
  192. Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
  193. Iron in ventricular remodeling and aneurysms post-myocardial infarction
  194. Case Reports
  195. Sirolimus potentiated angioedema: A case report and review of the literature
  196. Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report
  197. Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman’s disease: A case report
  198. Complete heart block associated with hepatitis A infection in a female child with fatal outcome
  199. Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review
  200. Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
  201. Advancing prenatal diagnosis: Echocardiographic detection of Scimitar syndrome in China – A case series
  202. Outcomes and complications of hemodialysis in patients with renal cancer following bilateral nephrectomy
  203. Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy
  204. Recurrent opportunistic infections in a HIV-negative patient with combined C6 and NFKB1 mutations: A case report, pedigree analysis, and literature review
  205. Letter to the Editor
  206. Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
  207. Erratum
  208. Erratum to “Bladder-embedded ectopic intrauterine device with calculus”
  209. Retraction
  210. Retraction of “XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis”
  211. Corrigendum
  212. Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”
  213. Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
  214. Special Issue The evolving saga of RNAs from bench to bedside - Part II
  215. Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma
  216. Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
  217. Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment
  218. Special Issue Advancements in oncology: bridging clinical and experimental research - Part I
  219. Ultrasound-guided transperineal vs transrectal prostate biopsy: A meta-analysis of diagnostic accuracy and complication rates
  220. Assessment of diagnostic value of unilateral systematic biopsy combined with targeted biopsy in detecting clinically significant prostate cancer
  221. SENP7 inhibits glioblastoma metastasis and invasion by dissociating SUMO2/3 binding to specific target proteins
  222. MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
  223. Analysis of postoperative complications in bladder cancer patients
  224. Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study
  225. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part I
  226. Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma
  227. Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer
  228. Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis
https://doi.org/10.1515/med-2024-1102
Schlagwörter für diesen Artikel
causalgia; chronic pain; complex regional pain syndrome; lidocaine; neuropathic pain; reflex sympathetic dystrophy
Creative Commons
BY 4.0

Artikel in diesem Heft

  1. Research Articles
  2. EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway
  3. STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
  4. Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
  5. The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma
  6. METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
  7. Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
  8. Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty
  9. Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
  10. Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma
  11. Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue
  12. Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
  13. Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease
  14. METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients
  15. Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis
  16. Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay
  17. Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity
  18. Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound
  19. Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement
  20. miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization
  21. The analyses of human MCPH1 DNA repair machinery and genetic variations
  22. Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
  23. Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma
  24. Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
  25. The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
  26. Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis
  27. Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
  28. Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer
  29. Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke
  30. The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
  31. Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study
  32. Lactate dehydrogenase to albumin ratio is associated with in-hospital mortality in patients with acute heart failure: Data from the MIMIC-III database
  33. CD36-mediated podocyte lipotoxicity promotes foot process effacement
  34. Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
  35. FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
  36. Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
  37. Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
  38. Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition
  39. Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy
  40. Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction
  41. High SEC61A1 expression predicts poor outcome of acute myeloid leukemia
  42. Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
  43. Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway
  44. Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
  45. Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
  46. Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
  47. Clinical analysis of incomplete rupture of the uterus secondary to previous cesarean section
  48. Abnormal sleep duration is associated with sarcopenia in older Chinese people: A large retrospective cross-sectional study
  49. No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study
  50. Identification and validation of autophagy-related genes in SSc
  51. Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming
  52. Evaluation of quality of life in patients with schizophrenia: An inpatient social welfare institution-based cross-sectional study
  53. The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
  54. Compilation of a self-management assessment scale for postoperative patients with aortic dissection
  55. Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
  56. Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
  57. Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2
  58. Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
  59. High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression
  60. Factors influencing cardiovascular system-related post-COVID-19 sequelae: A single-center cohort study
  61. HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis
  62. Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
  63. Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
  64. ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
  65. Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
  66. The role of enhanced expression of Cx43 in patients with ulcerative colitis
  67. Choosing a COVID-19 vaccination site might be driven by anxiety and body vigilance
  68. Role of ICAM-1 in triple-negative breast cancer
  69. Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
  70. HLA-DRB5 promotes immune thrombocytopenia via activating CD8+ T cells
  71. Efficacy and factors of myofascial release therapy combined with electrical and magnetic stimulation in the treatment of chronic pelvic pain syndrome
  72. Efficacy of tacrolimus monotherapy in primary membranous nephropathy
  73. Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking
  74. FBXO45 levels regulated ferroptosis renal tubular epithelial cells in a model of diabetic nephropathy by PLK1
  75. Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns
  76. Alpha-lipoic acid upregulates the PPARγ/NRF2/GPX4 signal pathway to inhibit ferroptosis in the pathogenesis of unexplained recurrent pregnancy loss
  77. Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study
  78. CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway
  79. miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
  80. Immune response analysis of solid organ transplantation recipients inoculated with inactivated COVID-19 vaccine: A retrospective analysis
  81. The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
  82. Clinical efficacy of dexamethasone combined with isoniazid in the treatment of tuberculous meningitis and its effect on peripheral blood T cell subsets
  83. Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis
  84. Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
  85. Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL2
  86. Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
  87. Risk factors of postoperative airway obstruction complications in children with oral floor mass
  88. Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction
  89. Physical activity and mental health trends in Korean adolescents: Analyzing the impact of the COVID-19 pandemic from 2018 to 2022
  90. Evaluating anemia in HIV-infected patients using chest CT
  91. Ponticulus posticus and skeletal malocclusion: A pilot study in a Southern Italian pre-orthodontic court
  92. Causal association of circulating immune cells and lymphoma: A Mendelian randomization study
  93. Assessment of the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals on treating renal fibrosis: A systematic review and meta-analysis
  94. Comprehensive landscape of integrator complex subunits and their association with prognosis and tumor microenvironment in gastric cancer
  95. New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: A drug Mendelian randomization study
  96. Population pharmacokinetics of meropenem in critically ill patients
  97. Comparison of the ability of newly inflammatory markers to predict complicated appendicitis
  98. Comparative morphology of the cruciate ligaments: A radiological study
  99. Immune landscape of hepatocellular carcinoma: The central role of TP53-inducible glycolysis and apoptosis regulator
  100. Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study
  101. SHP-1 mediates cigarette smoke extract-induced epithelial–mesenchymal transformation and inflammation in 16HBE cells
  102. Acute hyper-hypoxia accelerates the development of depression in mice via the IL-6/PGC1α/MFN2 signaling pathway
  103. The GJB3 correlates with the prognosis, immune cell infiltration, and therapeutic responses in lung adenocarcinoma
  104. Physical fitness and blood parameters outcomes of breast cancer survivor in a low-intensity circuit resistance exercise program
  105. Exploring anesthetic-induced gene expression changes and immune cell dynamics in atrial tissue post-coronary artery bypass graft surgery
  106. Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
  107. Analysis of the risk factors of the radiation-induced encephalopathy in nasopharyngeal carcinoma: A retrospective cohort study
  108. Reproductive outcomes in women with BRCA 1/2 germline mutations: A retrospective observational study and literature review
  109. Evaluation of upper airway ultrasonographic measurements in predicting difficult intubation: A cross-section of the Turkish population
  110. Prognostic and diagnostic value of circulating IGFBP2 in pancreatic cancer
  111. Postural stability after operative reconstruction of the AFTL in chronic ankle instability comparing three different surgical techniques
  112. Research trends related to emergence agitation in the post-anaesthesia care unit from 2001 to 2023: A bibliometric analysis
  113. Frequency and clinicopathological correlation of gastrointestinal polyps: A six-year single center experience
  114. ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
  115. Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
  116. Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
  117. The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae
  118. Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
  119. Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study
  120. Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway
  121. Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population
  122. Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
  123. Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study
  124. Decreased BIRC5-206 promotes epithelial–mesenchymal transition in nasopharyngeal carcinoma through sponging miR-145-5p
  125. Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
  126. Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis
  127. Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures
  128. The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial
  129. Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
  130. Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
  131. Parental control attitudes over their pre-school children’s diet
  132. The role of auto-HSCT in extranodal natural killer/T cell lymphoma
  133. Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy
  134. Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin
  135. ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
  136. The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study
  137. The unusual location of primary hydatid cyst: A case series study
  138. Intraoperative changes in electrophysiological monitoring can be used to predict clinical outcomes in patients with spinal cavernous malformation
  139. Obesity and risk of placenta accreta spectrum: A meta-analysis
  140. Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
  141. NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages
  142. The effect of COVID-19 lockdown on admission rates in Maternity Hospital
  143. Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
  144. Luteolin alleviates cerebral ischemia/reperfusion injury by regulating cell pyroptosis
  145. Therapeutic role of respiratory exercise in patients with tuberculous pleurisy
  146. Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
  147. Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
  148. DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy
  149. Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients
  150. Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
  151. Ferroptosis-related prognostic model of mantle cell lymphoma
  152. Observation of choking reaction and other related indexes in elderly painless fiberoptic bronchoscopy with transnasal high-flow humidification oxygen therapy
  153. A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022
  154. The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study
  155. Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
  156. Role of COX6C and NDUFB3 in septic shock and stroke
  157. Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
  158. Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
  159. Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation
  160. Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
  161. Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients
  162. Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
  163. Risk factors for progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fracture
  164. Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke
  165. The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
  166. Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
  167. Detection of serum FOXM1 and IGF2 in patients with ARDS and their correlation with disease and prognosis
  168. Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
  169. Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
  170. Review Articles
  171. Cutaneous signs of selected cardiovascular disorders: A narrative review
  172. XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
  173. A narrative review on adverse drug reactions of COVID-19 treatments on the kidney
  174. Emerging role and function of SPDL1 in human health and diseases
  175. Adverse reactions of piperacillin: A literature review of case reports
  176. Molecular mechanism and intervention measures of microvascular complications in diabetes
  177. Regulation of mesenchymal stem cell differentiation by autophagy
  178. Molecular landscape of borderline ovarian tumours: A systematic review
  179. Advances in synthetic lethality modalities for glioblastoma multiforme
  180. Investigating hormesis, aging, and neurodegeneration: From bench to clinics
  181. Frankincense: A neuronutrient to approach Parkinson’s disease treatment
  182. Sox9: A potential regulator of cancer stem cells in osteosarcoma
  183. Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients
  184. Advanced neuroimaging and criminal interrogation in lie detection
  185. Maternal factors for neural tube defects in offspring: An umbrella review
  186. The chemoprotective hormetic effects of rosmarinic acid
  187. CBD’s potential impact on Parkinson’s disease: An updated overview
  188. Progress in cytokine research for ARDS: A comprehensive review
  189. Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
  190. NRXN1-related disorders, attempt to better define clinical assessment
  191. Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
  192. Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
  193. Iron in ventricular remodeling and aneurysms post-myocardial infarction
  194. Case Reports
  195. Sirolimus potentiated angioedema: A case report and review of the literature
  196. Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report
  197. Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman’s disease: A case report
  198. Complete heart block associated with hepatitis A infection in a female child with fatal outcome
  199. Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review
  200. Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
  201. Advancing prenatal diagnosis: Echocardiographic detection of Scimitar syndrome in China – A case series
  202. Outcomes and complications of hemodialysis in patients with renal cancer following bilateral nephrectomy
  203. Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy
  204. Recurrent opportunistic infections in a HIV-negative patient with combined C6 and NFKB1 mutations: A case report, pedigree analysis, and literature review
  205. Letter to the Editor
  206. Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
  207. Erratum
  208. Erratum to “Bladder-embedded ectopic intrauterine device with calculus”
  209. Retraction
  210. Retraction of “XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis”
  211. Corrigendum
  212. Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”
  213. Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
  214. Special Issue The evolving saga of RNAs from bench to bedside - Part II
  215. Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma
  216. Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
  217. Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment
  218. Special Issue Advancements in oncology: bridging clinical and experimental research - Part I
  219. Ultrasound-guided transperineal vs transrectal prostate biopsy: A meta-analysis of diagnostic accuracy and complication rates
  220. Assessment of diagnostic value of unilateral systematic biopsy combined with targeted biopsy in detecting clinically significant prostate cancer
  221. SENP7 inhibits glioblastoma metastasis and invasion by dissociating SUMO2/3 binding to specific target proteins
  222. MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
  223. Analysis of postoperative complications in bladder cancer patients
  224. Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study
  225. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part I
  226. Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma
  227. Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer
  228. Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis
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Heruntergeladen am 25.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/med-2024-1102/html
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