Home Medicine Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
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Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019

  • Yunchao Wang , Junlin Jiang and Zhongxin Zhu EMAIL logo
Published/Copyright: November 29, 2024
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Open Medicine
From the journal Open Medicine Volume 19 Issue 1

Abstract

Background

High body mass index (BMI) is a significant risk factor for non-communicable diseases; however, its impact on disease burden in China remains understudied. This study aimed to analyze trends in the burden of type 2 diabetes mellitus (T2DM), stroke, and hypertensive heart disease (HHD) attributable to high BMI in China from 1990 to 2019.

Methods

We utilized data from the Global Burden of Disease 2019 study, quantifying disease burden through years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life years (DALYs). Joinpoint regression analysis was employed to determine temporal trends.

Results

The study revealed distinct gender-specific temporal trends. Men exhibited a consistent increase in disease burden across all three conditions. Women showed more nuanced patterns: a gradual rise in T2DM burden, an inverted U-shaped trend for stroke, and a U-shaped trend for HHD in terms of age-standardized DALYs. Age-specific analysis demonstrated that the burden of T2DM and stroke peaked in the 70–74-year age group, whereas HHD-related DALYs continued to increase with advancing age.

Conclusions

Our findings underscore the need for tailored obesity prevention and management strategies in Chinese healthcare settings, emphasizing early screening and intervention for high BMI, particularly in middle-aged and older adults.

Keywords: disease burden; type 2 diabetes mellitus; stroke; hypertension; body mass index

1 Introduction

Elevated body mass index (BMI ≥ 25 kg/m²) is a complex risk factor with far-reaching public health implications [1]. In recent decades, obesity rates have surged globally, driven by a multifaceted interplay of excessive calorie consumption, sedentary lifestyles, and diverse socio-environmental and genetic influences [2]. This trend poses significant health risks, as obesity is a well-established contributor to numerous non-communicable diseases (NCDs), including type 2 diabetes (T2DM), hypertension, stroke, and cardiovascular disorders [3,4,5].

China has witnessed a dramatic surge in NCDs over recent decades, driven by an aging population and increased exposure to major risk factors [6]. The Global Burden of Disease (GBD) study identifies T2DM, stroke, and hypertensive heart disease (HHD) as primary contributors to the disease burden attributable to high BMI [7,8]. However, research specifically examining the BMI-attributable burden of these diseases in China remains scarce. This knowledge gap is particularly concerning given China’s rapid economic development and lifestyle changes, which have fueled a significant rise in obesity rates [9,10].

To address this critical knowledge gap, our study aims to elucidate the temporal trends in the burden of T2DM, stroke, and HHD attributable to high BMI in China from 1990 to 2019, leveraging data from the GBD 2019 study. This 30-year analysis provides a comprehensive picture of how high BMI’s health impacts have evolved in China. Our findings contribute to the existing literature on NCD burden in China and offer valuable evidence to inform public health strategies aimed at mitigating the impact of high BMI on population health.

2 Methods

2.1 Data source and study design

The data utilized in this study are available on the Global Health Data Exchange GBD Results Tool (http://ghdx.healthdata.org/gbd-2019). Building upon its predecessor, GBD 2017, the 2019 iteration incorporates additional data sources and refined estimation methodologies [11,12,13]. The GBD Study provides the detailed information regarding 367 causes of death and disability and 87 risk factors for 204 countries and territories [11]. GBD produced sound and up-to-date evidence of trends at the global, regional, and national levels as a result of the shift in the global agenda and increased focus on NCD and injury. GBD studies used three main standardized modeling tools to process data, model, and generate each estimation of disease by age, location, sex, and year-Cause of Death Ensemble, DisMod-MR, and Spatiotemporal Gaussian Process Regression [14].

Our investigation focuses specifically on the temporal trends of T2DM, stroke, and HHD attributable to high BMI in China. For adults (ages 20+), high BMI was defined as BMI ≥ 25 kg/m2 [12]. To quantify disease burden, we employed multiple metrics: years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life years (DALYs). YLDs were calculated by multiplying the number of incident cases by the disability weight and mean disability duration. YLLs were derived by multiplying the estimated number of deaths by the standard life expectancy at the age of death. DALYs, representing the sum of YLDs and YLLs, provide a comprehensive measure of overall disease burden [15]. Our study is compliant with the Guidelines for Accurate and Transparent Health Estimates Reporting [16].

2.2 Statistical analysis

Joinpoint regression analysis was used to determine trends in YLDs, YLLs, and DALYs of T2DM, stroke, and HHD attributable to a high BMI. The maximum three joinpoints (four segments) were used to ensure the results were credible. For each trend segment identified by the mode, the annual percentage change (APC), calculated for each segmented line regression; average annual percent change (AAPC), calculated for the entire period; and 95% confidence interval (CI), were estimated [17]. The trend was considered decreasing (increasing) if APC and its 95% CI were both <0 (>0), and considered stable when the 95% CI overlapped with zero. Moreover, we analyzed the disease burden of different age groups in 2019. All analyses were performed using Joinpoint Regression Program (version 4.9.0.0, Statistical Methodology and Applications Branch, Surveillance Research Program, National Cancer Institute). P value <0.05 was considered significant.

3 Results

3.1 Disease burden of T2DM attributable to a high BMI

The trends in the sex-specific age-standardized YLDs, YLLs, and DALYs of T2DM attributable to a high BMI in China from 1990 to 2019 are shown in Figure 1a–c, and the results of sex-specific Joinpoint regression analyses are shown in Table 1. Generally, the age-standardized YLDs, YLLs, and DALYs have increased steadily over the three decades for men (AAPC: YLDs, 3.6, 95% CI, 3.2, 4.1; YLLs, 2.9, 95% CI, 2.7, 3.1; DALYs, 3.5, 95% CI, 3.3, 3.7). For women, age-standardized YLDs, YLLs, and DALYs largely increased near the period 2000–2004, and then continuously increased for YLDs and DALYs. For YLLs, the trend decreased in the period 2004–2014 and again increased in recent years. The age-standardized DALYs rates due to a high BMI by age in 2019 are shown in Figure 1d. For the comparison from 30 to 34 years to 90 to 94 years, DALYs first increased and then decreased after age 70–74 years for both men and women.

Figure 1 Burden of type 2 diabetes mellitus attributable to a high BMI by sex in China. (a) Age-standardized YLDs, rate per 100,000. (b) Age-standardized YLLs, rate per 100,000. (c) Age-standardized DALYs, rate per 100,000. (d) DALYs by age in 2019. Abbreviations: YLDs, years lived with disability; YLLs, years of life lost; DALYs, disability-adjusted life years.
Figure 1

Burden of type 2 diabetes mellitus attributable to a high BMI by sex in China. (a) Age-standardized YLDs, rate per 100,000. (b) Age-standardized YLLs, rate per 100,000. (c) Age-standardized DALYs, rate per 100,000. (d) DALYs by age in 2019. Abbreviations: YLDs, years lived with disability; YLLs, years of life lost; DALYs, disability-adjusted life years.

Table 1

Results of the Joinpoint regression models for trend analysis of burdens of type 2 diabetes mellitus attributable to a high BMI in China from 1990 to 2019

Category Sex Year APC 95% CI AAPC (1990–2019) 95% CI
Type 2 diabetes mellitus
YLDs Males 1990–2001 3.0* 2.6, 3.3 3.6* 3.2, 4.1
2001–2005 8.5* 5.8, 11.3
2005–2014 3.7* 3.2, 4.3
2014–2019 1.2* 0.0, 2.3
Females 1990–2001 2.5* 2.2, 2.8 2.7* 2.3, 3.1
2001–2004 9.4* 5.4, 13.6
2004–2009 2.7* 1.5, 3.9
2009–2019 1.0* 0.7, 1.3
YLLs Males 1990–1994 0.9* 0.3, 1.5 2.9* 2.7, 3.1
1994–2004 5.2* 5.0, 5.4
2004–2007 0.5 −1.4, 2.3
2007–2019 2.3* 2.2, 2.4
Females 1990–1996 1.0* 0.5, 1.5 1.2* 1.0, 1.4
1996–2004 4.9* 4.5, 5.3
2004–2014 −1.9* −2.2, −1.6
2014–2019 1.7* 1.0, 2.4
DALYs Males 1990–2001 3.2* 3.1, 3.4 3.5* 3.3, 3.7
2001–2004 8.4* 6.4, 10.5
2004–2014 3.3* 3.1, 3.4
2014–2019 1.6* 1.1, 2.0
Females 1990–2000 2.3* 2.3, 2.4 2.2* 2.1, 2.3
2000–2004 7.5* 6.9, 8.1
2004–2017 0.5* 0.5, 0.6
2017–2019 2.3* 1.2, 3.4

*Significantly different from 0 (P  <  0.05). Abbreviations. YLDs: years lived with disability; YLLs: years of life lost; DALYs: disability-adjusted life years; APC: annual percent change; AAPC: average annual percent change; CI: confidence interval.

3.2 Disease burden of stroke attributable to a high BMI

The trends in the sex-specific age-standardized YLDs, YLLs, and DALYs of stroke attributable to a high BMI in China from 1990 to 2019 are shown in Figure 2a–c, and the results of sex-specific Joinpoint regression analyses are shown in Table 2. The age-standardized YLDs, YLLs, and DALYs were higher in men than women. Generally, the age-standardized YLDs, YLLs, and DALYs have increased steadily over the three decades for men (AAPC: YLDs, 3.0, 95% CI, 2.8, 3.2; YLLs, 0.9, 95% CI, 0.7, 1.2; DALYs, 1.1, 95% CI, 0.8, 1.4). For women, there were a steady increasing trend for YLDs, a steady increasing trend from 1997 to 2003, and a largely decreasing from 2003 to 2015 for YLLs, and a steady increasing trend from 1999 to 2003, and a largely decreasing from 2003 to 2015 for DALYs. The age-standardized DALYs rates due to a high BMI by age in 2019 are shown in Figure 2d. For the comparison from 30 to 34 years to 90 to 94 years, DALYs first increased and then decreased after age 70–74 years for both men and women.

Figure 2 Burden of stroke attributable to a high BMI by sex in China. (a) Age-standardized YLDs, rate per 100,000. (b) Age-standardized YLLs, rate per 100,000. (c) Age-standardized DALYs, rate per 100,000. (d) DALYs by age in 2019. Abbreviations: YLDs, years lived with disability; YLLs, years of life lost; DALYs, disability-adjusted life years.
Figure 2

Burden of stroke attributable to a high BMI by sex in China. (a) Age-standardized YLDs, rate per 100,000. (b) Age-standardized YLLs, rate per 100,000. (c) Age-standardized DALYs, rate per 100,000. (d) DALYs by age in 2019. Abbreviations: YLDs, years lived with disability; YLLs, years of life lost; DALYs, disability-adjusted life years.

Table 2

Results of the Joinpoint regression models for trend analysis of burdens of stroke attributable to a high BMI in China from 1990 to 2019

Category Sex Year APC 95% CI AAPC (1990–2019) 95% CI
Stroke
YLDs Males 1990–1995 2.1* 1.7, 2.6 3.0* 2.8, 3.2
1995–2000 3.9* 3.3, 4.5
2000–2005 1.5* 0.9, 2.1
2005–2019 3.5* 3.4, 3.6
1990–1994 1.6* 1.2, 2.0 2.4* 2.3, 2.5
1994–2000 3.4* 3.1, 3.7
2000–2006 1.1* 0.8, 1.5
2006–2019 2.8* 2.7, 2.8
YLLs Males 1990–1995 0.4 −0.5, 1.2 0.9* 0.7, 1.2
1995–2001 2.8* 1.9, 3.7
2001–2012 0.8* 0.5, 1.1
2012–2019 −0.0 −0.5, 0.5
Females 1990–1997 −0.1 −0.4, 0.2 −0.9* −1.0, −0.7
1997–2003 1.6* 1.1, 2.2
2003–2015 −2.9* −3.0, −2.7
2015–2019 0.1 −0.6, 0.9
DALYs Males 1990–1995 0.5 −0.4, 1.3 1.1* 0.8, 1.4
1995–2001 2.8* 2.0, 3.7
2001–2012 0.9* 0.6, 1.2
2012–2019 0.3 −0.2, 0.8
Females 1990–1996 0.0 −0.4, 0.4 −0.4* −0.6, −0.3
1996–2003 1.5* 1.1, 1.9
2003–2015 −2.2* −2.3, −2.0
2015–2019 0.9* 0.1, 1.6

*Significantly different from 0 (P  <  0.05). Abbreviations. YLDs: years lived with disability; YLLs: years of life lost; DALYs: disability-adjusted life years; APC: annual percent change; AAPC: average annual percent change; CI: confidence interval.

3.3 Disease burden of HHD attributable to a high BMI

The trends in the sex-specific age-standardized YLDs, YLLs, and DALYs of HHD attributable to a high BMI in China from 1990 to 2019 are shown in Figure 3a–c, and the results of sex-specific Joinpoint regression analyses are shown in Table 3. For YLDs, there were steady increasing trends for both men and women from 1990 to 2019. For YLLs and DALYs, the change in trends was U-shaped for both men and women, with the turning point near 2005. The age-standardized DALYs rates due to a high BMI by age in 2019 are shown in Figure 2d. For the comparison from 30 to 34 years to 90 to 94 years, DALYs kept increasing with aging.

Figure 3 Burden of HHD attributable to a high BMI by sex in China. (a) Age-standardized YLDs, rate per 100,000. (b) Age-standardized YLLs, rate per 100,000. (c) Age-standardized DALYs, rate per 100,000. (d) DALYs by age in 2019. Abbreviations: YLDs, years lived with disability; YLLs, years of life lost; DALYs, disability-adjusted life years.
Figure 3

Burden of HHD attributable to a high BMI by sex in China. (a) Age-standardized YLDs, rate per 100,000. (b) Age-standardized YLLs, rate per 100,000. (c) Age-standardized DALYs, rate per 100,000. (d) DALYs by age in 2019. Abbreviations: YLDs, years lived with disability; YLLs, years of life lost; DALYs, disability-adjusted life years.

Table 3

Results of the Joinpoint regression models for trend analysis of burdens of HHD attributable to a high BMI in China from 1990 to 2019

Category Sex Year APC 95% CI AAPC (1990–2019) 95% CI
HHD
YLDs Males 1990–1993 0.6 −0.9, 2.1 2.4* 2.1, 2.6
1993–2006 2.3* 2.1, 2.5
2006–2010 4.1* 2.6, 5.7
2010–2019 2.3* 2.0, 2.5
Females 1990–2005 2.3* 2.3, 2.4 2.5* 2.4, 2.7
2005–2014 2.8* 2.7, 3.0
2014–2017 1.2 −0.0, 2.4
2017–2019 4.5* 3.3, 5.7
YLLs Males 1990–2000 −3.2* −3.4, −2.9 −0.2 −0.4, 0.1
2000–2005 −6.7* −7.6, −5.7
2005–2014 7.0* 6.6, 7.4
2014–2019 0.1 −0.6, 0.8
Females 1990–2000 −3.6* −3.9, −3.3 −1.4* −1.7, −1.1
2000–2006 −5.4* −6.2, −4.6
2006–2014 4.0* 3.4, 4.5
2014–2019 −0.4 −1.2, 0.5
DALYs Males 1990–2000 −2.8* −3.1, −2.6 0.0 −0.2, 0.2
2000–2005 −5.9* −6.7, −5.0
2005–2014 6.6* 6.3, 7.0
2014–2019 0.3 −0.4, 0.9
Females 1990–2000 −3.3* −3.5, 3.0 −1.1* −1.3, −0.8
2000–2006 −4.6* −5.3, −3.8
2006–2014 3.8* 3.3, 4.3
2014–2019 −0.0 −0.8, 0.8

*Significantly different from 0 (P  <  0.05). Abbreviations. YLDs: years lived with disability; YLLs: years of life lost; DALYs: disability-adjusted life years; APC: annual percent change; AAPC: average annual percent change; CI: confidence interval.

4 Discussion

This study provides a comprehensive analysis of the disease burden attributable to high BMI for T2DM, stroke, and HHD in China from 1990 to 2019, utilizing Joinpoint regression analyses. Our findings reveal distinct gender-specific temporal trends: men exhibited a consistent increase in disease burden across all three conditions, while women showed more nuanced patterns. Specifically, for women, we observed a gradual rise in T2DM burden, an inverted U-shaped trend for stroke, and a U-shaped trend for HHD in terms of age-standardized DALYs. Moreover, the age-specific analysis demonstrated that the burden of T2DM and stroke peaked in the 70–74-year age group, whereas HHD-related DALYs continued to increase with advancing age.

These findings align with global health projections. The World Health Organization (WHO) estimates that the global prevalence of diabetes mellitus will increase from 9.3% to 10.2% by 2030 [18]. The significant rise in the prevalence of individuals with BMI ≥ 25 kg/m2 in both genders is particularly concerning, given the strong association between elevated BMI and T2DM risk [19]. Previous GBD studies have identified BMI as the leading risk factor for T2DM-related mortality [20]. Longitudinal data from the China Health and Nutrition Survey corroborate these findings, demonstrating that substantial long-term BMI gain significantly increases T2DM risk among Chinese adults [21]. The intricate interplay between obesity and T2DM pathophysiology underscores the potential for synergistic therapeutic approaches [22].

Stroke remains a significant global health challenge, ranking as the third-leading cause of DALYs and the second-leading cause of death worldwide in 2019 [23]. GBD studies have highlighted the substantial potential for reducing stroke burden through mitigation of modifiable risk factors [24]. Consequently, WHO recommendations for effective stroke prevention strategies encompass interventions targeting hypertension, dyslipidemia, unhealthy diet, physical inactivity, and high BMI [25]. Notably, high BMI emerged as the second leading risk factor for stroke in 2019 and exhibited the fastest growth rate among stroke risk factors between 1990 and 2019 [23]. Meta-analyses have further substantiated the independent association between high BMI and progressively increasing stroke risk [26]. However, the “Obesity Paradox” theory, suggesting potentially better outcomes for patients with high BMI compared to leaner or malnourished individuals [27], underscores the need for further high-quality research to elucidate the complex relationship between obesity and stroke outcomes.

Hypertension, a leading risk factor for cardiovascular disease, contributes significantly to the rapidly increasing disease burden in China [28]. The likelihood of developing chronic hypertension and cardiovascular events rises with increased visceral adiposity [29]. Obesity-induced alterations in nocturnal blood pressure patterns and the potential for blood pressure reduction through weight loss highlight the intricate relationship between adiposity and cardiovascular health [30]. The pathophysiological mechanisms underlying obesity-related HHD are multifaceted, involving pro-inflammatory states, increased sympathetic tone, and enhanced reactive oxygen species production [29]. The complex interplay between HHD and obesity, influenced by myriad contributing factors, emphasizes the critical importance of prevention and early intervention strategies for both conditions.

To our knowledge, this study represents the first investigation of the burden of T2DM, stroke, and HHD attributable to high BMI in China, utilizing the latest GBD study estimates. However, several limitations warrant consideration. First, the GBD study uses complex statistical models to estimate disease burden across different countries and time periods. While these models are sophisticated and aim to provide the best possible estimates, they are still based on available data and certain assumptions. This modeling process can introduce uncertainties and potential biases, especially in areas where primary data might be limited or of varying quality. Second, Asian populations tend to have a higher percentage of body fat and increased health risks at lower BMI levels compared to Western populations, and The World Health Organization and several Asian countries have suggested lower BMI cut-offs for overweight and obesity in Asian populations. Thus, by using the standard ≥25 kg/m2 definition, the GBD study might underestimate the true burden of disease attributable to high BMI in China [31,32]. Finally, the absence of urban–rural stratification in our analysis, due to data limitations, highlights the importance of considering regional variations in epidemiological studies, especially in a country as large and diverse as China [33].

In conclusion, our findings underscore the need for tailored obesity prevention and management strategies in Chinese healthcare settings, emphasizing early screening and intervention for high BMI, particularly in middle-aged and older adults, and integrating BMI management into existing chronic disease prevention programs to address the increasing burden of high BMI-related diseases in China. Our findings highlight the urgent need for comprehensive public health policies that address the economic impact of increasing obesity-related disease burden, promote healthy diets and physical activity, and tackle the social determinants of obesity to mitigate healthcare costs, productivity losses, and overall societal impact in China.

  1. Funding information: The authors state no funding is involved.

  2. Author contributions: YCW and JLJ contributed to data collection, analysis, and writing of the manuscript. ZXZ contributed to study design and writing of the manuscript. The authors read and approved the final manuscript.

  3. Conflict of interest: The authors declare that they have no competing interests.

  4. Data availability statement: All data used in this study are freely available online at: http://ghdx.healthdata.org/gbd-results-tool.

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Received: 2023-07-13
Revised: 2024-09-13
Accepted: 2024-10-18
Published Online: 2024-11-29

© 2024 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Articles in the same Issue

  1. Research Articles
  2. EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway
  3. STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
  4. Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
  5. The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma
  6. METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
  7. Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
  8. Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty
  9. Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
  10. Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma
  11. Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue
  12. Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
  13. Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease
  14. METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients
  15. Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis
  16. Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay
  17. Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity
  18. Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound
  19. Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement
  20. miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization
  21. The analyses of human MCPH1 DNA repair machinery and genetic variations
  22. Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
  23. Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma
  24. Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
  25. The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
  26. Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis
  27. Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
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  31. Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study
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  34. Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
  35. FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
  36. Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
  37. Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
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  42. Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
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  46. Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
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  53. The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
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  55. Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
  56. Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
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  58. Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
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  142. The effect of COVID-19 lockdown on admission rates in Maternity Hospital
  143. Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
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  146. Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
  147. Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
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  157. Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
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  166. Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
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  175. Adverse reactions of piperacillin: A literature review of case reports
  176. Molecular mechanism and intervention measures of microvascular complications in diabetes
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  178. Molecular landscape of borderline ovarian tumours: A systematic review
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  180. Investigating hormesis, aging, and neurodegeneration: From bench to clinics
  181. Frankincense: A neuronutrient to approach Parkinson’s disease treatment
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  189. Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
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  213. Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
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  216. Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
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https://doi.org/10.1515/med-2024-1087
Keywords for this article
disease burden; type 2 diabetes mellitus; stroke; hypertension; body mass index
Creative Commons
BY 4.0

Articles in the same Issue

  1. Research Articles
  2. EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway
  3. STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
  4. Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
  5. The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma
  6. METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
  7. Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
  8. Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty
  9. Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
  10. Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma
  11. Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue
  12. Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
  13. Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease
  14. METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients
  15. Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis
  16. Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay
  17. Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity
  18. Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound
  19. Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement
  20. miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization
  21. The analyses of human MCPH1 DNA repair machinery and genetic variations
  22. Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
  23. Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma
  24. Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
  25. The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
  26. Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis
  27. Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
  28. Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer
  29. Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke
  30. The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
  31. Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study
  32. Lactate dehydrogenase to albumin ratio is associated with in-hospital mortality in patients with acute heart failure: Data from the MIMIC-III database
  33. CD36-mediated podocyte lipotoxicity promotes foot process effacement
  34. Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
  35. FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
  36. Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
  37. Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
  38. Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition
  39. Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy
  40. Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction
  41. High SEC61A1 expression predicts poor outcome of acute myeloid leukemia
  42. Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
  43. Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway
  44. Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
  45. Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
  46. Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
  47. Clinical analysis of incomplete rupture of the uterus secondary to previous cesarean section
  48. Abnormal sleep duration is associated with sarcopenia in older Chinese people: A large retrospective cross-sectional study
  49. No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study
  50. Identification and validation of autophagy-related genes in SSc
  51. Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming
  52. Evaluation of quality of life in patients with schizophrenia: An inpatient social welfare institution-based cross-sectional study
  53. The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
  54. Compilation of a self-management assessment scale for postoperative patients with aortic dissection
  55. Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
  56. Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
  57. Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2
  58. Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
  59. High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression
  60. Factors influencing cardiovascular system-related post-COVID-19 sequelae: A single-center cohort study
  61. HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis
  62. Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
  63. Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
  64. ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
  65. Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
  66. The role of enhanced expression of Cx43 in patients with ulcerative colitis
  67. Choosing a COVID-19 vaccination site might be driven by anxiety and body vigilance
  68. Role of ICAM-1 in triple-negative breast cancer
  69. Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
  70. HLA-DRB5 promotes immune thrombocytopenia via activating CD8+ T cells
  71. Efficacy and factors of myofascial release therapy combined with electrical and magnetic stimulation in the treatment of chronic pelvic pain syndrome
  72. Efficacy of tacrolimus monotherapy in primary membranous nephropathy
  73. Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking
  74. FBXO45 levels regulated ferroptosis renal tubular epithelial cells in a model of diabetic nephropathy by PLK1
  75. Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns
  76. Alpha-lipoic acid upregulates the PPARγ/NRF2/GPX4 signal pathway to inhibit ferroptosis in the pathogenesis of unexplained recurrent pregnancy loss
  77. Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study
  78. CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway
  79. miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
  80. Immune response analysis of solid organ transplantation recipients inoculated with inactivated COVID-19 vaccine: A retrospective analysis
  81. The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
  82. Clinical efficacy of dexamethasone combined with isoniazid in the treatment of tuberculous meningitis and its effect on peripheral blood T cell subsets
  83. Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis
  84. Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
  85. Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL2
  86. Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
  87. Risk factors of postoperative airway obstruction complications in children with oral floor mass
  88. Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction
  89. Physical activity and mental health trends in Korean adolescents: Analyzing the impact of the COVID-19 pandemic from 2018 to 2022
  90. Evaluating anemia in HIV-infected patients using chest CT
  91. Ponticulus posticus and skeletal malocclusion: A pilot study in a Southern Italian pre-orthodontic court
  92. Causal association of circulating immune cells and lymphoma: A Mendelian randomization study
  93. Assessment of the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals on treating renal fibrosis: A systematic review and meta-analysis
  94. Comprehensive landscape of integrator complex subunits and their association with prognosis and tumor microenvironment in gastric cancer
  95. New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: A drug Mendelian randomization study
  96. Population pharmacokinetics of meropenem in critically ill patients
  97. Comparison of the ability of newly inflammatory markers to predict complicated appendicitis
  98. Comparative morphology of the cruciate ligaments: A radiological study
  99. Immune landscape of hepatocellular carcinoma: The central role of TP53-inducible glycolysis and apoptosis regulator
  100. Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study
  101. SHP-1 mediates cigarette smoke extract-induced epithelial–mesenchymal transformation and inflammation in 16HBE cells
  102. Acute hyper-hypoxia accelerates the development of depression in mice via the IL-6/PGC1α/MFN2 signaling pathway
  103. The GJB3 correlates with the prognosis, immune cell infiltration, and therapeutic responses in lung adenocarcinoma
  104. Physical fitness and blood parameters outcomes of breast cancer survivor in a low-intensity circuit resistance exercise program
  105. Exploring anesthetic-induced gene expression changes and immune cell dynamics in atrial tissue post-coronary artery bypass graft surgery
  106. Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
  107. Analysis of the risk factors of the radiation-induced encephalopathy in nasopharyngeal carcinoma: A retrospective cohort study
  108. Reproductive outcomes in women with BRCA 1/2 germline mutations: A retrospective observational study and literature review
  109. Evaluation of upper airway ultrasonographic measurements in predicting difficult intubation: A cross-section of the Turkish population
  110. Prognostic and diagnostic value of circulating IGFBP2 in pancreatic cancer
  111. Postural stability after operative reconstruction of the AFTL in chronic ankle instability comparing three different surgical techniques
  112. Research trends related to emergence agitation in the post-anaesthesia care unit from 2001 to 2023: A bibliometric analysis
  113. Frequency and clinicopathological correlation of gastrointestinal polyps: A six-year single center experience
  114. ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
  115. Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
  116. Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
  117. The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae
  118. Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
  119. Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study
  120. Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway
  121. Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population
  122. Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
  123. Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study
  124. Decreased BIRC5-206 promotes epithelial–mesenchymal transition in nasopharyngeal carcinoma through sponging miR-145-5p
  125. Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
  126. Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis
  127. Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures
  128. The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial
  129. Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
  130. Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
  131. Parental control attitudes over their pre-school children’s diet
  132. The role of auto-HSCT in extranodal natural killer/T cell lymphoma
  133. Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy
  134. Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin
  135. ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
  136. The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study
  137. The unusual location of primary hydatid cyst: A case series study
  138. Intraoperative changes in electrophysiological monitoring can be used to predict clinical outcomes in patients with spinal cavernous malformation
  139. Obesity and risk of placenta accreta spectrum: A meta-analysis
  140. Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
  141. NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages
  142. The effect of COVID-19 lockdown on admission rates in Maternity Hospital
  143. Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
  144. Luteolin alleviates cerebral ischemia/reperfusion injury by regulating cell pyroptosis
  145. Therapeutic role of respiratory exercise in patients with tuberculous pleurisy
  146. Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
  147. Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
  148. DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy
  149. Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients
  150. Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
  151. Ferroptosis-related prognostic model of mantle cell lymphoma
  152. Observation of choking reaction and other related indexes in elderly painless fiberoptic bronchoscopy with transnasal high-flow humidification oxygen therapy
  153. A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022
  154. The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study
  155. Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
  156. Role of COX6C and NDUFB3 in septic shock and stroke
  157. Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
  158. Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
  159. Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation
  160. Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
  161. Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients
  162. Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
  163. Risk factors for progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fracture
  164. Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke
  165. The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
  166. Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
  167. Detection of serum FOXM1 and IGF2 in patients with ARDS and their correlation with disease and prognosis
  168. Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
  169. Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
  170. Review Articles
  171. Cutaneous signs of selected cardiovascular disorders: A narrative review
  172. XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
  173. A narrative review on adverse drug reactions of COVID-19 treatments on the kidney
  174. Emerging role and function of SPDL1 in human health and diseases
  175. Adverse reactions of piperacillin: A literature review of case reports
  176. Molecular mechanism and intervention measures of microvascular complications in diabetes
  177. Regulation of mesenchymal stem cell differentiation by autophagy
  178. Molecular landscape of borderline ovarian tumours: A systematic review
  179. Advances in synthetic lethality modalities for glioblastoma multiforme
  180. Investigating hormesis, aging, and neurodegeneration: From bench to clinics
  181. Frankincense: A neuronutrient to approach Parkinson’s disease treatment
  182. Sox9: A potential regulator of cancer stem cells in osteosarcoma
  183. Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients
  184. Advanced neuroimaging and criminal interrogation in lie detection
  185. Maternal factors for neural tube defects in offspring: An umbrella review
  186. The chemoprotective hormetic effects of rosmarinic acid
  187. CBD’s potential impact on Parkinson’s disease: An updated overview
  188. Progress in cytokine research for ARDS: A comprehensive review
  189. Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
  190. NRXN1-related disorders, attempt to better define clinical assessment
  191. Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
  192. Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
  193. Iron in ventricular remodeling and aneurysms post-myocardial infarction
  194. Case Reports
  195. Sirolimus potentiated angioedema: A case report and review of the literature
  196. Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report
  197. Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman’s disease: A case report
  198. Complete heart block associated with hepatitis A infection in a female child with fatal outcome
  199. Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review
  200. Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
  201. Advancing prenatal diagnosis: Echocardiographic detection of Scimitar syndrome in China – A case series
  202. Outcomes and complications of hemodialysis in patients with renal cancer following bilateral nephrectomy
  203. Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy
  204. Recurrent opportunistic infections in a HIV-negative patient with combined C6 and NFKB1 mutations: A case report, pedigree analysis, and literature review
  205. Letter to the Editor
  206. Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
  207. Erratum
  208. Erratum to “Bladder-embedded ectopic intrauterine device with calculus”
  209. Retraction
  210. Retraction of “XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis”
  211. Corrigendum
  212. Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”
  213. Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
  214. Special Issue The evolving saga of RNAs from bench to bedside - Part II
  215. Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma
  216. Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
  217. Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment
  218. Special Issue Advancements in oncology: bridging clinical and experimental research - Part I
  219. Ultrasound-guided transperineal vs transrectal prostate biopsy: A meta-analysis of diagnostic accuracy and complication rates
  220. Assessment of diagnostic value of unilateral systematic biopsy combined with targeted biopsy in detecting clinically significant prostate cancer
  221. SENP7 inhibits glioblastoma metastasis and invasion by dissociating SUMO2/3 binding to specific target proteins
  222. MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
  223. Analysis of postoperative complications in bladder cancer patients
  224. Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study
  225. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part I
  226. Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma
  227. Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer
  228. Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis
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