Startseite Medizin Frankincense: A neuronutrient to approach Parkinson’s disease treatment
Artikel Open Access

Frankincense: A neuronutrient to approach Parkinson’s disease treatment

  • Vittorio Calabrese , Naomi Osakabe , Foziya Khan , Uwe Wenzel , Sergio Modafferi , Lidia Nicolosi , Tilman Fritsch , Ursula M. Jacob , Ali S. Abdelhameed und Luay Rashan EMAIL logo
Veröffentlicht/Copyright: 17. Juni 2024
Artikel downloaden (PDF)
Open Medicine
Aus der Zeitschrift Open Medicine Band 19 Heft 1

Abstract

Parkinson’s disease (PD), characterized by tremor, slowness of movement, stiffness, and poor balance, is due to a significant loss of dopaminergic neurons in the substantia nigra pars compacta and dopaminergic nerve terminals in the striatum with deficit of dopamine. To date the mechanisms sustaining PD pathogenesis are under investigation; however, a solid body of experimental evidence involves neuroinflammation, mitochondrial dysfunction, oxidative stress, and apoptotic cell death as the crucial factors operating in the pathogenesis of PD. Nutrition is known to modulate neuroinflammatory processes implicated in the pathogenesis and progression of this neurodegenerative disorder. Consistent with this notion, the Burseraceae family, which includes the genera Boswellia and Commiphora, are attracting emerging interest in the treatment of a wide range of pathological conditions, including neuroinflammation and cognitive decline. Bioactive components present in these species have been shown to improve cognitive function and to protect neurons from degeneration in in vitro, animal, as well as clinical research. These effects are mediated through the anti-inflammatory, antiamyloidogenic, anti-apoptotic, and antioxidative properties of bioactive components. Although many studies have exploited possible therapeutic approaches, data from human studies are lacking and their neuroprotective potential makes them a promising option for preventing and treating major neurodegenerative disorders.

Keywords: antioxidants; hormesis; Parkinson’s disease; vitagenes

1 Neuronutrition and Parkinson’s disease (PD)

It is widely recognized that a progressive deterioration of physiological functions and metabolic processes underlies the pathogenic determinism of aging [1,2,3,4]. Thus, one of prominent idea of modern society remains the concept of healthy aging. As a disease associated with the elderly, in PD patients, a significant neuronal loss is the consequence of multifactorial events, primarily overproduction of reactive oxygen species (ROS) by mitochondria causing DNA oxidation and damage, apoptosis, and ferroptotic death of dopaminergic neurons [5,6,7,8]. In these settings, no efficient clinical treatment has been developed yet; however, increasing evidence indicates that nutritional antioxidants can delay the onset of disorders associated with aging, in spite of absence of active anti-aging drugs available. Once neurodegeneration begins, it can only be slowed but not stopped, emphasizing the clinical relevance of the disease.

After Alzheimer’s disease (AD), PD – which shows an increased frequency after the age of 50 years – represents the second most prevalent form of neurodegeneration, with selective loss of dopaminergic neurons in the pars compacta substantia nigra and significant drop of striatal dopamine content responsible for major clinical disturbances observed in this disease [5]. A large body of experimental evidence highlights a fundamental role of oxidative and nitrosative stress in the pathogenesis of PD [6], mainly due to the pro-oxidant action of catechols, including DOPA and dopamine, which undergo redox cycling processes generating cytotoxic products, primarily through formation of covalent bonds between their quinone redox active forms and important macromolecules, such as proteins and peptides where thiol groups are the primary target of oxidative attack [7]. Consistent with this notion, excitotoxic mechanisms are promoted by mitochondrially encoded defects occurring at levels of complex subunits, primarily complex I of the electron transport chain [8], which ensues in bioenergetic transduction defects, with impairment of oxidative phosphorylation, ATP, and glutathione depletion, and ultimately enhanced vulnerability to excitotoxic insults [9]. Studies from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in mice as well as in primates have provided corroborating evidence that neuronal NO synthase inhibition induces neuroprotection, raising the conceivable possibility that the use of excitatory amino acid antagonists of neuronal NO synthase inhibitors might provide a rational for novel interventions in PD therapeutics [10].

Frankincense is derived from the Boswellia sacra Flück tree and represents a common source of traditional medicine. The word “frankincense” has got its origin from a very old French word, “franc encens,” which means “pure incense” or “pure and noble high-quality incense” [11]. The sweet aroma of smoldering frankincense gum has been used for centuries. The Boswellia sacra Flück tree, when cut at the base, exudes a toughened resin or gum-like substance [12]. Figure 1 illustrates the B. sacra tree, which belongs to the Boswellia genus. The Boswellia genus comprises 25 species that are widely distributed across various regions such as India, the Arabian Peninsula, North Africa, Somalia, Ethiopia, and Eritrea [13]. Boswellia sacra Flueck, one of the 25 species in the family Boswellia (Burseraceae), has been used for centuries as an incense ingredient due to its fragrant gums and resins. Southwest Oman, the Hadramawt, and the Mahra areas of Yemen are the only places on the Arabian Peninsula where we can find this native species [14,15]. Since before the dawn of recorded history, frankincense has been one of the most highly prized commodities [16]. Frankincense is known to be produced by several Boswellia species, mainly from B. carterii (Somalia), B. sacra (Oman), and B. serrata (India) [17]. Figure 2 illustrates the chemical structure of common boswellic acids found in frankincense. Literature data suggest that Boswellia resin possesses antioxidative properties, which is consistent with the presence of primary terpenic natural phenolic compounds, such as cis-Verbenol, Pinene, Hepthene trimethyl, and trans-Ocimeneare, as determined by gas chromatographic analysis, which were associated with a significant total phenol content (TPC), as well as to a 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity [18,19]. Consistently, antioxidants such as limonene (22.4%) and esters such as duva-3,9,13-trien-1,5a-diol-1-acetate (21.4%) are the main compounds responsible for antioxidant activity [20]. Frankincense is composed of essential oil (5–9%), gum (20–23%), and resin (60%). Ingredients analysis to identify individual compounds showed a variety of bioactive substances including terpenoids, phenols, flavonoids, and phenylpropanoid [21]. The main active components isolated from oleo-gum resin of B. serrata are boswellic acid (BA), which possesses a wide range of biological and pharmacological effects, are endowed with neuroprotective activities [22,23,24]. BAs, pentacyclic triterpenic acids, show multiple biological effects, including anti-inflammation, antioxidative, and anti-excitotoxicity, all impacting therapeutically neurological disorders. In particular, neuroprotection induced by BAs is connected with an action on neurotoxic aggregates, which are decreased by BA treatment, an effect associated with decreased oxidative stress and amelioration of cognitive defects. Consistent with these notions, among the most important active principles within the multi-component mixture of Boswellia serrata resin, there is the pentacyclic triterpenoid Acetyl 11-keto-b-boswellic acid (AKBA). Boswellia serrata resin extracts (BAs) not only show an in vivo antioxidant activity in many pathological conditions, such as stroke, but also bowel disease, myocardial I/R injury, and pulmonary fibrosis. The neuroprotective potential of pentacyclic triterpenoid has recently gained increasing attention as, for instance, oleanolic acid shows protective effects on cerebral ischemic damage and H2O2-induced injury in vitro. Recently, it has been shown that a naturally occurring pentacyclic triterpenoid, ursolic acid, exerts neuroprotection in mice exposed to cerebral ischemia through the activation of Nrf2 pathway. Another study has provided experimental evidence that AKBA may have even a better antioxidant effect compared with ursolic acid. Based on these studies, AKBA, sharing similar chemical structure with ursolic acid, may promote the neuroprotection via the Nrf2 pathway [25]. Only recently, due to its action on proliferative processes, migration, metastasis, angiogenesis, and apoptosis promotion, BA has been proposed as interesting compound and effective agent against brain tumorigenesis [26]. Moreover, the antioxidative therapeutic potential from Boswellia serrata has been demonstrated in cerebro-vascular systems [26], as well as in mice in a rotenone-induced model of PD, where a significant attenuation of nigrostriatal dopaminergic neuronal loss has been demonstrated, an effect associated with reduced accumulation of α-synuclein and modulation of AMPK phosphorylation, as also shown in SHSY5 cells [27]. These results suggest that Boswellia-derived compounds protect dopaminergic neurons from rotenone neurotoxicity via activation of the AMPK signal and reduction in α-synuclein aggregation and associated neuroinflammation [22,28,29].

Figure 1 Boswellia sacra in Wadi Dawkah, a natural park of frankincense-producing trees in Oman.
Figure 1

Boswellia sacra in Wadi Dawkah, a natural park of frankincense-producing trees in Oman.

Figure 2 Chemical structure of main constituents of genus Boswellia.
Figure 2

Chemical structure of main constituents of genus Boswellia.

Recent investigations from our laboratory have provided compelling evidence that a single oral dose of 500 mg/kg Boswellia sacra administered 1 h after the trauma was capable of decreasing anxiety and altered locomotor activity, which are post-traumatic stress disorder markers, while ameliorating spatial learning and memory processes. When measuring biochemical markers of oxidative insult promoted by trauma-induced neuroinflammatory changes, we measured decreased levels of lipid peroxidation, as well as proinflammatory cytokines after Boswellia treatment, with parallel increase in antioxidant enzymes superoxide dismutase (SOD) and glutathione-Peroxidases. We also observed in the same experimental conditions that the increase in caspase-3, caspase-8, caspase-9, Bcl-2, and cytochrome C were diminished by Boswellia administration, with increases in Bcl2, indicating a significant regulatory action of apoptotic pathways [22,30].

1.1 Caenorhabditis elegans as a model for investigating the impact of redox modulators on PD

Since α-synuclein is considered to represent an amyloidogenic and pathogenic protein leading to the degeneration of dopaminergic neurons and the phenotype of PD, most of the C. elegans Parkinson´s models rely on the transgenic expression of α-synuclein under control of a dopaminergic or a pan-neuronal promoter [31,32]. Often, α-synuclein is fused to fluorescent proteins in order to enable the visualization of cellular degeneration as well [33]. However, in the absence of α-synuclein, specific labeling of dopaminergic neurons (two ADE and four CEP neurons in the head plus two PDE neurons in the posterior part of the body) by a fluorescent marker, which is expressed under the dopamine transporter promoter (Pdat-1), can serve the evaluation of dopaminergic degeneration. This has been exemplified by investigating the degeneration of dopaminergic neurons in response to the neurotoxin 6-hydroxydopamine (6-OHDA) in strains in which the dopaminergic forms of thioredoxin reductase or thioredoxin, i.e., trxr-1 and trx-5, were knocked out [34]. Increased degeneration of dopaminergic neurons in response to 6-OHDA was observed in the strain with trx-5 null alleles but even more pronounced in the strain with trxr-1 null alleles [34]. In a vicious cycle, redox imbalance is inevitably linked to mitochondrial dysfunction. In this context, it has been demonstrated that in C. elegans expressing α-synuclein in fusion with yellow fluorescent protein (YFP) under control of a muscle cell promoter, silencing of nuo-5 (linked to oxidative phosphorylation], F25B4.7 (shows ATP transmembrane transporter activity), and C05D11.9 (endowed with ribonuclease activity) led to increased α-synuclein aggregation and the attenuation of the mitochondrial quality control system, as exemplified by reduced transcript levels of a number of chaperones [35]. The most downregulated gene was hsp-60 [35], which suggests a decreased SOD-2 expression in association with increased mitochondrial oxidative stress and impaired respiration [36]. Using models that express α-synuclein fused to green fluorescent protein in dopaminergic neurons or fused to YFP transgenically overexpressed in body wall muscle cells, tyrosol, a polyphenol from extra virgin olive oil, was shown to reduce ROS and enhance the expression of chaperones and antioxidative enzymes [37]. Those effects were associated with reduced degeneration of dopaminergic neurons and ameliorated motility impairment in the strain expressing α-synuclein in muscle cells. Using the same C. elegans strain with the body wall muscle cell expression of α-synuclein, sesquiterpenoids from Artemisia pallens decreased the levels of aggregated α-synuclein [38]. One of them, bicyclogermacrene, increased the transcript levels of the SOD-1, SOD-2, and SOD-4 genes, encoding isoforms of the antioxidative enzyme, finally suggesting that the selected sesquiterpenoid acts through maintenance of cellular redox state and proteostasis (Table 1).

Table 1

Antioxidants present in Frankincense

Antioxidant Results
Terpenes are natural phenolic compounds Primary compounds in frankincense are cis-verbenol, pinene, hepthene trimethyl, and trans-Ocimeneare
Bilayer films of gelatin/frankincense with varying concentrations of Hyssopus officinalis and ascorbic acid Significant changes in TPC and DPPH radical-scavenging activity
Other antioxidants Limonene (22.4%) and esters such as duva-3,9,13-trien-1,5a-diol-1- acetate (1.4%)
Limonene, spathulenol, curzerene, beta selinene, isocericenine, myrcenol, and germacrene Antioxidant and free radical scavenging properties and plays a significant role in fighting diseases that are related to the oxidative damage. Sesquiterpenoids have been found to possess antibacterial, antifungal, and anesthetic properties

2 Conclusion and future directions

Redox modulation of endogenous cellular resilience via cellular stress response signal pathway represents a novel convergent mechanism to approach therapeutically diseases associated with oxidative damage, such in neurodegenerative disorders [2]. Maintenance of repair processes at efficient functioning level is fundamental for brain cells survival and, consequently, overall quality of life. This is accomplished by a complex network of longevity assurance processes based on the expression and activity of redox regulated genes, termed vitagenes [39,40,41,42,43]. Consistent to this notion, upregulation of vitagenes likely results in a decreased occurrence of age-related disorders, with optimization of biochemical mechanisms underlying aging, as well as age-related processes. In this perspective, prolongation of a healthy life span may be a reachable clinical endpoint. For instance, in the United States with exponentially increasingly aged population, predictions indicate that the number of AD patients will reach 14 million in the mid-twenty-first century, if no effective interventions will be established [44,45,46,47]. This implies an immense economic and personal burden on USA nation welfare system, with similar conditions applying worldwide. Strong evidence exists to suggest that oxidative stress and impaired proteome, lipidome, and metabolome system networks sustain in a vicious cycle in the pathogenesis of major neurodegenerative disorders. With respect to this, brain-accessible redox active compounds, such as natural polyphenols, may represent a potentially active mean to implement therapeutic strategy limiting the onset of all degenerative diseases associated with oxidative stress, such as major brain neurological disorders. Moreover, vitagene system operates efficiently in the context of a longevity network which, by regulating hormetic nutrition processes in the whole organism, as well as at the level of single cells and tissues, by modulation of the energy status, regulate and optimize the functional state of mitochondria, mitochondrial ROS concentration, and ultimately coordinating biochemical information flow within signaling pathways, result in increasing life span. This highlights the central roles of HSF1 and Nrf2/keap1 neurobiology in stress resistance and proteostasis, whose enhanced activity during development and early adulthood is important for the stability of the proteome and the health of the cell across the entire lifespan. PD is a multifaceted disease with a convergence of multiple genetic, environmental, and cellular factors. Consistent with this evidence, while antioxidants and anti-inflammatory compounds may benefit, the disease’s complexity suggests that a single treatment approach may not address all aspects of PD pathogenesis, rather a multitargeted approach is warranted. In the present study, we evidence a lack of data from human studies, which is a significant limitation, as without robust clinical evidence, it is challenging to assess the true therapeutic potential of these compounds in humans. As we already started in our laboratory, clinical intervention trials are necessary to clearly elucidate the redox active therapeutic potential of these compounds impacting efficiently the disease pathogenesis, as well as the course of its progression. On the other hand, to date, we are not aware of negative impact on the neuroinflammatory component of PD pathogenesis either in animal-based models or in clinical studies. In addition, here we discuss the involvement of oxidative stress, mitochondrial dysfunction, and neuroinflammation, operating in a vicious cycle in the PD pathogenesis; however, it is important to note that the precise mechanisms by which these compounds exert their effects are not fully understood, and further research is needed to elucidate completely these mechanisms. More in general. while the potential benefits of Boswellia-derived compounds in PD are intriguing, more rigorous clinical studies are needed to establish their efficacy and safety in human populations. Additionally, a comprehensive understanding of their mechanisms of action and potential interactions with other PD therapies is crucial for their successful integration into PD multitargeted treatment strategies.

# These authors equally contributed as first authors.

tel: +96823237357

  1. Funding information: This study was supported by grants from “Piano di incentivi per la Ricerca, Linea Intervento 2 PIACERI, 2020–2022,” University of Catania, Italy; and Researchers Supporting Project number [RSPD2024R750], King Saud University, Riyadh, Saudi Arabia.

  2. Author contributions: Conceptualization: V.C.; N.O.; L.R.; Data curation: L.N.; S.M.; F.K.; Funding acquisition: A. S. A., L.R.; V.C.; Resources: A.S.A.; L.R. V.C.; Methodology: T.F.; U.M.J; Project administration: U.M.J.; T.F.; Supervision: V.C.; L.R.; Writing—original draft: V.C.; L.R.; N.O.; U.W.. All authors have read and agreed to the published version of the manuscript.

  3. Conflict of interest: Vittorio Calabrese serves as Editor in Chief for Open Medicine, but it did not influenced peer-review process. The authors declare that they have no conflicts of interest.

  4. Data availability statement: Data sharing is not applicable to this article as no datasets were generated or analysed during the current study.

References

[1] Calabrese V, Mancuso C, Ravagna A, Perluigi M, Cini C, De Marco C, et al. In vivo induction of heat shock proteins in the substantia nigra following L-DOPA administration is associated with increased activity of mitochondrial complex I and nitrosative stress in rats: regulation by glutathione redox state. J Neurochem. 2007;101:709–17. 10.1111/j.1471-4159.2006.04367.x.Suche in Google Scholar PubMed

[2] Calabrese V, Cornelius C, Dinkova-Kostova AT, Calabrese EJ, Mattson MP. Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal. 2010;29(12):1034–7. 10.1177/0960327110383641.Suche in Google Scholar PubMed

[3] Calabrese V, Fariello RG. Regional distribution of malonaldehyde in mouse brain. Biochem Pharmacol. 1988;37:2287–8. 10.1016/0006-2952[88]90595-3.Suche in Google Scholar

[4] Siracusa R, Scuto M, Fusco R, Trovato A, Ontario ML, Crea R, et al. Anti-inflammatory and anti-oxidant activity of hidrox in rotenone-induced Parkinson’s disease in mice. Antioxid [Basel]. 2020;9:82. 10.3390/antiox9090824.Suche in Google Scholar PubMed PubMed Central

[5] Di Rosa G, Brunetti G, Scuto M, Trovato Salinaro A, Calabrese EJ, Crea R, et al. Healthspan enhancement by olive polyphenols in C. elegans wild type and Parkinson’s models. Int J Mol Sci. 2020;21:3893. 10.3390/ijms21113893.Suche in Google Scholar PubMed PubMed Central

[6] Brunetti G, Di Rosa G, Scuto M, Leri M, Stefani M, Schmitz-Linneweber C, et al. Healthspan maintenance and prevention of Parkinson’s-like phenotypes with hydroxytyrosol and oleuropein aglycone in C. elegans. Int J Mol Sci. 2020;21:2588. 10.3390/ijms21072588.Suche in Google Scholar PubMed PubMed Central

[7] Calabrese V, Jacob UM, Fritsch T, Abdelhameed AS, Osakabe N. Redoxomics in ageing and neurodegenerative disorders: from bench to clinics. Transl Med UniSa. 2023;25(2):50–1. 10.37825/2239-9747.1045.Suche in Google Scholar PubMed PubMed Central

[8] Calabrese EJ, Mattson MP, Dhawan G, Kapoor R, Calabrese V, Giordano J. Hormesis: A potential strategic approach to the treatment of neurodegenerative disease. Int Rev Neurobiol. 2020;155:271–30. 10.1016/bs.irn.2020.03.024.Suche in Google Scholar PubMed

[9] Nam Y, Na J, Ma SX, Park H, Park H, Lee E, et al. DJ-1 protects cell death from a mitochondrial oxidative stress due to GBA1 deficiency. Genes Genomics. 2024;46(5):519–29. 10.1007/s13258-024-01506-w. Epub ahead of print.Suche in Google Scholar PubMed

[10] Hu XL, Lv XY, Wang R, Long H, Feng JH, Wang BL, et al. Optimization of N-phenylpropenoyl-l-amino acids as potent and selective inducible nitric oxide synthase inhibitors for Parkinson’s disease. J Med Chem. 2021;64:7760–77. 10.1021/acs.jmedchem.1c00578.Suche in Google Scholar PubMed

[11] Efferth T, Oesch F. Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities. Semin Cancer Biol. 2022;80:39–57.10.1016/j.semcancer.2020.01.015Suche in Google Scholar PubMed

[12] Almeida-da-Silva CLC, Sivakumar N, Asadi H, Chang-Chien A, Qoronfleh MW, Ojcius DM, et al. Effects of frankincense compounds on infection, inflammation, and oral health. Molecules. 2022;27:41–74. 10.3390/molecules27134174.Suche in Google Scholar PubMed PubMed Central

[13] Assefa M, Dekebo H, Kassa H, Habtu A, Fitwi G, Redi-Abshiro M. Biophysical and chemical investigations of frankincense of Boswellia papyrifera from North and Northwestern Ethiopia. J Chem Pharm Res. 2012;4:1074–89.Suche in Google Scholar

[14] Raffaelli M, Mosti M, Tardelli M. Boswellia sacra Flueck in the Hasik area [Eastern Dhofar, Oman] and a list of the surrounding flora. Webbia. 2006;61:245–51.10.1080/00837792.2006.10670804Suche in Google Scholar

[15] Rashan L, Hakkim FL, Idrees M, Essa MM, Velusamy T, Al-Baloshi M, et al. Boswellia gum resin and essential oils: Potential health benefits − An evidence based review. Int J Nutr Pharmacol Neurol Dis. 2019;9:53–71.10.4103/ijnpnd.ijnpnd_11_19Suche in Google Scholar

[16] Van Wyk BE. A review of commercially important African medicinal plants. J Ethnopharmacol. 2015;176:118–34.10.1016/j.jep.2015.10.031Suche in Google Scholar PubMed

[17] Bokelmann JM. Medicinal herbs in primary care: An evidence-guided reference for healthcare providers. In Frankincense/Boswellia [Boswellia serrata/sacra/carterii]: Bark Resin; Bokelmann, J.M., Ed.; Medicinal herbs in primary case. Elsevier: Amsterdam, The Netherlands; 2021. p. 351–60.10.1016/B978-0-323-84676-9.00046-5Suche in Google Scholar

[18] Sharma A, Chhikara S, Ghodekar S, Bhatia S, Kharya M, Gajbhiye V, et al. Phytochemical and pharmacological investigations on Boswellia serrata. Pharmacogn Rev. 2009;3(5):206.Suche in Google Scholar

[19] Sharma AU, Jain J, Kharya MD, Namdeo A, Mahadik KR. Antioxidant activity of aqueous extract of Boswellia serrata. J Chem Biol Physic Sci. 2011;1:60–71.Suche in Google Scholar

[20] Hartmann RM, Fillmann HS, Martins MI, Meurer L, Marroni NP. Boswellia serrata has beneficial antiinflammatory and antioxidant properties in a model of experimental colitis. Phytother Res. 2014;28:1392–8.10.1002/ptr.5142Suche in Google Scholar PubMed

[21] Ayub MA, Hanif MA, Sarfraz RA, Shahid M. Biological activity of Boswellia serrata Roxb. oleo gum resin essential oil: effects of extraction by supercritical carbon dioxide and traditional methods. Int J Food Prop. 2018;21:808–20.10.1080/10942912.2018.1439957Suche in Google Scholar

[22] Interdonato L, Marino Y, Impellizzeri D, D’Amico R, Siracusa R, Fusco R, et al. Autophagy machinery plays an essential role in traumatic brain injury-induced apoptosis and its related behavioral abnormalities in mice: focus on Boswellia Sacra gum resin. Front Physiol. 2024;14:1320960. 10.3389/fphys.2023.1320960.Suche in Google Scholar PubMed PubMed Central

[23] Ding Y, Chen M, Wang M, Li Y, Wen A. Posttreatment with 11-keto-β-boswellic acid ameliorates cerebral ischemia–reperfusion injury: Nrf2/HO-1 pathway as a potential mechanism. Mol Neurobiol. 2015;52:1430–9.10.1007/s12035-014-8929-9Suche in Google Scholar PubMed

[24] Ebrahimpour S, Fazeli M, Mehri S, Taherianfard M, Hosseinzadeh H. Boswellic acid improves cognitive function in a rat model through its antioxidant activity: neuroprotective effect of boswellic acid. J Pharmacopunct. 2017;20(1):10.10.3831/KPI.2017.20.001Suche in Google Scholar PubMed PubMed Central

[25] Ding Y, Chen M, Wang M, Wang M, Zhang T, Park J, et al. Neuroprotection by acetyl-11-keto-β-Boswellic acid, in ischemic brain injury involves the Nrf2/HO-1 defense pathway. Sci Rep. 2014;4:7002. 10.1038/srep07002.Suche in Google Scholar PubMed PubMed Central

[26] Rajabian A, Farzanehfar M, Hosseini H, Arab FL, Nikkhah A. Boswellic acids as promising agents for the management of brain diseases. Life Sci. 2023;312:121196. 10.1016/j.lfs.2022.121196. Epub 2022 Nov 16.Suche in Google Scholar PubMed

[27] Shadfar S, Khanal S, Bohara G, Kim G, Sadigh-Eteghad S, Ghavami S, et al. Methanolic extract of Boswellia serrata Gum protects the nigral dopaminergic neurons from rotenone-induced neurotoxicity. Mol Neurobiol. 2022;59:5874–90. 10.1007/s12035-022-02943-y.Suche in Google Scholar PubMed PubMed Central

[28] Mohamed TM, Youssef MAM, Bakry AA, El-Keiy MM. Alzheimer’s disease improved through the activity of mitochondrial chain complexes and their gene expression in rats by boswellic acid. Metab Brain Dis. 2021;36:255–64.10.1007/s11011-020-00639-7Suche in Google Scholar PubMed

[29] Ameen AM, Elkazaz AY, Mohammad HMF, Barakat BM. Anti-inflammatory and neuroprotective activity of boswellic acids in rotenone parkinsonian rats. Can J Physiol Pharmacol. 2017;95:819–29. 10.1139/cjpp-2016-0158.Suche in Google Scholar PubMed

[30] Zhang M, Shan H, Chang P, Wang T, Dong W, Chen X, et al. Hydrogen sulfide offers neuroprotection on traumatic brain injury in parallel with reduced apoptosis and autophagy in mice. PLoS One. 2014;9(1):e87241. 10.1371/journal.pone.0087241.Suche in Google Scholar PubMed PubMed Central

[31] Lakso M, Vartiainen S, Moilanen AM, Sirviö J, Thomas JH, Nass R, et al. Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein. Neurochem. 2003 Jul;86(1):165–72. 10.1046/j.1471-4159.2003.01809.x.Suche in Google Scholar PubMed

[32] Kuwahara T, Koyama A, Koyama S, Yoshina S, Ren CH, Kato T, et al. A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans. Hum Mol Genet. 2008 Oct;17(19):2997–3009. 10.1093/hmg/ddn198.Suche in Google Scholar PubMed

[33] Cooper JF, Van Raamsdonk JM. Modeling Parkinson’s disease in C. elegans. J Parkinsons Dis. 2018;8(1):17–32. 10.3233/JPD-171258.Suche in Google Scholar PubMed PubMed Central

[34] Arodin L, Miranda-Vizuete A, Swoboda P, Fernandes AP. Protective effects of the thioredoxin and glutaredoxin systems in dopamine-induced cell death. Free Radic Biol Med. 2014 Aug;73:328–36. 10.1016/j.freeradbiomed.2014.05.011.Suche in Google Scholar PubMed

[35] Sarkar A, Hameed R, Mishra A, Bhatta RS, Nazir A. Genetic modulators associated with regulatory surveillance of mitochondrial quality control, play a key role in regulating stress pathways and longevity in C. elegans. Life Sci. 2022 Feb;290:120226. 10.1016/j.lfs.2021.120226.Suche in Google Scholar PubMed

[36] Szegő ÉM, Dominguez-Meijide A, Gerhardt E, König A, Koss DJ, Li W, et al. Cytosolic trapping of a mitochondrial heat shock protein is an early pathological event in synucleinopathies. Cell Rep. 2019 Jul;28(1):65–77.e6. 10.1016/j.celrep.2019.06.009.Suche in Google Scholar PubMed

[37] Garcia-Moreno JC, Porta de la Riva M, Martínez-Lara E, Siles E, Cañuelo A. Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson’s disease. Neurobiol Aging. 2019 Oct;82:60–8. 10.1016/j.neurobiolaging. 2019.07.003.Suche in Google Scholar

[38] Trivedi M, Singh S, Pandey T, Gupta SK, Verma RS, Pandey R. Sesquiterpenoids isolated from davana (Artemisia pallens Wall. ex DC) mitigates parkinsonism in Caenorhabditis elegans disease model. Biochem Biophys Res Commun. 2022 Jun;609:15–22. 10.1016/j.bbrc.2022.04.005.Suche in Google Scholar PubMed

[39] Armas FV, D’Angiulli A. Neuroinflammation and neurodegeneration of the central nervous system from air pollutants: A scoping review. Toxics. 2022;10(11):666. 10.3390/toxics10110666.Suche in Google Scholar PubMed PubMed Central

[40] Cordaro M, Modafferi S, D’Amico R, Fusco R, Genovese T, Peritore AF, et al. Natural compounds such as hericium erinaceus and coriolus versicolor modulate neuroinflammation, oxidative stress and lipoxin A4 expression in rotenone-induced Parkinson’s disease in mice. Biomedicines. 2022;10(10):2505. 10.3390/biomedicines10102505.Suche in Google Scholar PubMed PubMed Central

[41] Modafferi S, Lupo G, Tomasello M, Rampulla F, Ontario M, Scuto M, et al. Antioxidants, hormetic nutrition, and autism. Curr Neuropharmacol. 2024;22(7):1156–68. 10.2174/1570159X21666230817085811.Suche in Google Scholar PubMed PubMed Central

[42] Osakabe N, Modafferi S, Ontario ML, Rampulla F, Zimbone V, Migliore MR, et al. Polyphenols in inner ear neurobiology, health and disease: from bench to clinics. Medicina [Kaunas]. 2023;59:2045. 10.3390/medicina59112045.Suche in Google Scholar PubMed PubMed Central

[43] Di Paola R, Siracusa R, Fusco R, Ontario M, Cammilleri G, Pantano L, et al. Redox modulation of meniere disease by coriolus versicolor treatment, a nutritional mushroom approach with neuroprotective potential. Curr Neuropharmacol. 2023 Dec 8. 10.2174/1570159X22666231206153936.Suche in Google Scholar PubMed

[44] Calabrese EJ, Nascarella M, Pressman P, Hayes AW, Dhawan G, Kapoor R, et al. Hormesis determines lifespan. Ageing Res Rev. 2024;94:102181. 10.1016/j.arr.2023.102181.Suche in Google Scholar PubMed

[45] Calabrese EJ, Osakabe N, Di Paola R, Siracusa R, Fusco R, D’Amico R, et al. Hormesis defines the limits of lifespan. Ageing Res Rev. 2023;91:102074. 10.1016/j.arr.2023.102074.Suche in Google Scholar PubMed

[46] Butterfield DA, Boyd-Kimball D, Reed TT. Cellular stress response (Hormesis) in response to bioactive nutraceuticals with relevance to Alzheimer disease. Antioxid Redox Signal. 2023;38:643–69. 10.1089/ars.2022.0214.Suche in Google Scholar PubMed PubMed Central

[47] Perluigi M, Di Domenico F, Butterfield DA. Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease. Physiol Rev. 2024;104:103–97. 10.1152/physrev.00030.2022.Suche in Google Scholar PubMed

Received: 2024-04-20
Revised: 2024-06-03
Accepted: 2024-06-05
Published Online: 2024-06-17

© 2024 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Artikel in diesem Heft

  1. Research Articles
  2. EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway
  3. STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
  4. Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
  5. The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma
  6. METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
  7. Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
  8. Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty
  9. Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
  10. Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma
  11. Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue
  12. Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
  13. Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease
  14. METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients
  15. Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis
  16. Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay
  17. Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity
  18. Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound
  19. Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement
  20. miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization
  21. The analyses of human MCPH1 DNA repair machinery and genetic variations
  22. Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
  23. Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma
  24. Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
  25. The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
  26. Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis
  27. Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
  28. Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer
  29. Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke
  30. The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
  31. Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study
  32. Lactate dehydrogenase to albumin ratio is associated with in-hospital mortality in patients with acute heart failure: Data from the MIMIC-III database
  33. CD36-mediated podocyte lipotoxicity promotes foot process effacement
  34. Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
  35. FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
  36. Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
  37. Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
  38. Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition
  39. Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy
  40. Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction
  41. High SEC61A1 expression predicts poor outcome of acute myeloid leukemia
  42. Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
  43. Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway
  44. Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
  45. Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
  46. Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
  47. Clinical analysis of incomplete rupture of the uterus secondary to previous cesarean section
  48. Abnormal sleep duration is associated with sarcopenia in older Chinese people: A large retrospective cross-sectional study
  49. No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study
  50. Identification and validation of autophagy-related genes in SSc
  51. Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming
  52. Evaluation of quality of life in patients with schizophrenia: An inpatient social welfare institution-based cross-sectional study
  53. The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
  54. Compilation of a self-management assessment scale for postoperative patients with aortic dissection
  55. Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
  56. Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
  57. Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2
  58. Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
  59. High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression
  60. Factors influencing cardiovascular system-related post-COVID-19 sequelae: A single-center cohort study
  61. HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis
  62. Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
  63. Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
  64. ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
  65. Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
  66. The role of enhanced expression of Cx43 in patients with ulcerative colitis
  67. Choosing a COVID-19 vaccination site might be driven by anxiety and body vigilance
  68. Role of ICAM-1 in triple-negative breast cancer
  69. Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
  70. HLA-DRB5 promotes immune thrombocytopenia via activating CD8+ T cells
  71. Efficacy and factors of myofascial release therapy combined with electrical and magnetic stimulation in the treatment of chronic pelvic pain syndrome
  72. Efficacy of tacrolimus monotherapy in primary membranous nephropathy
  73. Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking
  74. FBXO45 levels regulated ferroptosis renal tubular epithelial cells in a model of diabetic nephropathy by PLK1
  75. Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns
  76. Alpha-lipoic acid upregulates the PPARγ/NRF2/GPX4 signal pathway to inhibit ferroptosis in the pathogenesis of unexplained recurrent pregnancy loss
  77. Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study
  78. CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway
  79. miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
  80. Immune response analysis of solid organ transplantation recipients inoculated with inactivated COVID-19 vaccine: A retrospective analysis
  81. The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
  82. Clinical efficacy of dexamethasone combined with isoniazid in the treatment of tuberculous meningitis and its effect on peripheral blood T cell subsets
  83. Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis
  84. Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
  85. Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL2
  86. Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
  87. Risk factors of postoperative airway obstruction complications in children with oral floor mass
  88. Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction
  89. Physical activity and mental health trends in Korean adolescents: Analyzing the impact of the COVID-19 pandemic from 2018 to 2022
  90. Evaluating anemia in HIV-infected patients using chest CT
  91. Ponticulus posticus and skeletal malocclusion: A pilot study in a Southern Italian pre-orthodontic court
  92. Causal association of circulating immune cells and lymphoma: A Mendelian randomization study
  93. Assessment of the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals on treating renal fibrosis: A systematic review and meta-analysis
  94. Comprehensive landscape of integrator complex subunits and their association with prognosis and tumor microenvironment in gastric cancer
  95. New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: A drug Mendelian randomization study
  96. Population pharmacokinetics of meropenem in critically ill patients
  97. Comparison of the ability of newly inflammatory markers to predict complicated appendicitis
  98. Comparative morphology of the cruciate ligaments: A radiological study
  99. Immune landscape of hepatocellular carcinoma: The central role of TP53-inducible glycolysis and apoptosis regulator
  100. Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study
  101. SHP-1 mediates cigarette smoke extract-induced epithelial–mesenchymal transformation and inflammation in 16HBE cells
  102. Acute hyper-hypoxia accelerates the development of depression in mice via the IL-6/PGC1α/MFN2 signaling pathway
  103. The GJB3 correlates with the prognosis, immune cell infiltration, and therapeutic responses in lung adenocarcinoma
  104. Physical fitness and blood parameters outcomes of breast cancer survivor in a low-intensity circuit resistance exercise program
  105. Exploring anesthetic-induced gene expression changes and immune cell dynamics in atrial tissue post-coronary artery bypass graft surgery
  106. Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
  107. Analysis of the risk factors of the radiation-induced encephalopathy in nasopharyngeal carcinoma: A retrospective cohort study
  108. Reproductive outcomes in women with BRCA 1/2 germline mutations: A retrospective observational study and literature review
  109. Evaluation of upper airway ultrasonographic measurements in predicting difficult intubation: A cross-section of the Turkish population
  110. Prognostic and diagnostic value of circulating IGFBP2 in pancreatic cancer
  111. Postural stability after operative reconstruction of the AFTL in chronic ankle instability comparing three different surgical techniques
  112. Research trends related to emergence agitation in the post-anaesthesia care unit from 2001 to 2023: A bibliometric analysis
  113. Frequency and clinicopathological correlation of gastrointestinal polyps: A six-year single center experience
  114. ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
  115. Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
  116. Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
  117. The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae
  118. Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
  119. Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study
  120. Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway
  121. Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population
  122. Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
  123. Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study
  124. Decreased BIRC5-206 promotes epithelial–mesenchymal transition in nasopharyngeal carcinoma through sponging miR-145-5p
  125. Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
  126. Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis
  127. Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures
  128. The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial
  129. Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
  130. Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
  131. Parental control attitudes over their pre-school children’s diet
  132. The role of auto-HSCT in extranodal natural killer/T cell lymphoma
  133. Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy
  134. Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin
  135. ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
  136. The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study
  137. The unusual location of primary hydatid cyst: A case series study
  138. Intraoperative changes in electrophysiological monitoring can be used to predict clinical outcomes in patients with spinal cavernous malformation
  139. Obesity and risk of placenta accreta spectrum: A meta-analysis
  140. Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
  141. NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages
  142. The effect of COVID-19 lockdown on admission rates in Maternity Hospital
  143. Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
  144. Luteolin alleviates cerebral ischemia/reperfusion injury by regulating cell pyroptosis
  145. Therapeutic role of respiratory exercise in patients with tuberculous pleurisy
  146. Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
  147. Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
  148. DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy
  149. Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients
  150. Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
  151. Ferroptosis-related prognostic model of mantle cell lymphoma
  152. Observation of choking reaction and other related indexes in elderly painless fiberoptic bronchoscopy with transnasal high-flow humidification oxygen therapy
  153. A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022
  154. The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study
  155. Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
  156. Role of COX6C and NDUFB3 in septic shock and stroke
  157. Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
  158. Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
  159. Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation
  160. Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
  161. Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients
  162. Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
  163. Risk factors for progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fracture
  164. Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke
  165. The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
  166. Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
  167. Detection of serum FOXM1 and IGF2 in patients with ARDS and their correlation with disease and prognosis
  168. Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
  169. Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
  170. Review Articles
  171. Cutaneous signs of selected cardiovascular disorders: A narrative review
  172. XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
  173. A narrative review on adverse drug reactions of COVID-19 treatments on the kidney
  174. Emerging role and function of SPDL1 in human health and diseases
  175. Adverse reactions of piperacillin: A literature review of case reports
  176. Molecular mechanism and intervention measures of microvascular complications in diabetes
  177. Regulation of mesenchymal stem cell differentiation by autophagy
  178. Molecular landscape of borderline ovarian tumours: A systematic review
  179. Advances in synthetic lethality modalities for glioblastoma multiforme
  180. Investigating hormesis, aging, and neurodegeneration: From bench to clinics
  181. Frankincense: A neuronutrient to approach Parkinson’s disease treatment
  182. Sox9: A potential regulator of cancer stem cells in osteosarcoma
  183. Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients
  184. Advanced neuroimaging and criminal interrogation in lie detection
  185. Maternal factors for neural tube defects in offspring: An umbrella review
  186. The chemoprotective hormetic effects of rosmarinic acid
  187. CBD’s potential impact on Parkinson’s disease: An updated overview
  188. Progress in cytokine research for ARDS: A comprehensive review
  189. Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
  190. NRXN1-related disorders, attempt to better define clinical assessment
  191. Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
  192. Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
  193. Iron in ventricular remodeling and aneurysms post-myocardial infarction
  194. Case Reports
  195. Sirolimus potentiated angioedema: A case report and review of the literature
  196. Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report
  197. Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman’s disease: A case report
  198. Complete heart block associated with hepatitis A infection in a female child with fatal outcome
  199. Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review
  200. Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
  201. Advancing prenatal diagnosis: Echocardiographic detection of Scimitar syndrome in China – A case series
  202. Outcomes and complications of hemodialysis in patients with renal cancer following bilateral nephrectomy
  203. Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy
  204. Recurrent opportunistic infections in a HIV-negative patient with combined C6 and NFKB1 mutations: A case report, pedigree analysis, and literature review
  205. Letter to the Editor
  206. Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
  207. Erratum
  208. Erratum to “Bladder-embedded ectopic intrauterine device with calculus”
  209. Retraction
  210. Retraction of “XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis”
  211. Corrigendum
  212. Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”
  213. Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
  214. Special Issue The evolving saga of RNAs from bench to bedside - Part II
  215. Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma
  216. Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
  217. Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment
  218. Special Issue Advancements in oncology: bridging clinical and experimental research - Part I
  219. Ultrasound-guided transperineal vs transrectal prostate biopsy: A meta-analysis of diagnostic accuracy and complication rates
  220. Assessment of diagnostic value of unilateral systematic biopsy combined with targeted biopsy in detecting clinically significant prostate cancer
  221. SENP7 inhibits glioblastoma metastasis and invasion by dissociating SUMO2/3 binding to specific target proteins
  222. MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
  223. Analysis of postoperative complications in bladder cancer patients
  224. Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study
  225. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part I
  226. Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma
  227. Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer
  228. Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis
https://doi.org/10.1515/med-2024-0988
Schlagwörter für diesen Artikel
antioxidants; hormesis; Parkinson’s disease; vitagenes
Creative Commons
BY 4.0

Artikel in diesem Heft

  1. Research Articles
  2. EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway
  3. STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
  4. Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
  5. The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma
  6. METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
  7. Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
  8. Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty
  9. Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
  10. Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma
  11. Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue
  12. Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
  13. Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease
  14. METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients
  15. Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis
  16. Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay
  17. Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity
  18. Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound
  19. Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement
  20. miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization
  21. The analyses of human MCPH1 DNA repair machinery and genetic variations
  22. Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
  23. Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma
  24. Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
  25. The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
  26. Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis
  27. Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
  28. Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer
  29. Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke
  30. The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
  31. Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study
  32. Lactate dehydrogenase to albumin ratio is associated with in-hospital mortality in patients with acute heart failure: Data from the MIMIC-III database
  33. CD36-mediated podocyte lipotoxicity promotes foot process effacement
  34. Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
  35. FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
  36. Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
  37. Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
  38. Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition
  39. Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy
  40. Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction
  41. High SEC61A1 expression predicts poor outcome of acute myeloid leukemia
  42. Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
  43. Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway
  44. Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
  45. Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
  46. Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
  47. Clinical analysis of incomplete rupture of the uterus secondary to previous cesarean section
  48. Abnormal sleep duration is associated with sarcopenia in older Chinese people: A large retrospective cross-sectional study
  49. No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study
  50. Identification and validation of autophagy-related genes in SSc
  51. Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming
  52. Evaluation of quality of life in patients with schizophrenia: An inpatient social welfare institution-based cross-sectional study
  53. The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
  54. Compilation of a self-management assessment scale for postoperative patients with aortic dissection
  55. Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
  56. Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
  57. Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2
  58. Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
  59. High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression
  60. Factors influencing cardiovascular system-related post-COVID-19 sequelae: A single-center cohort study
  61. HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis
  62. Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
  63. Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
  64. ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
  65. Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
  66. The role of enhanced expression of Cx43 in patients with ulcerative colitis
  67. Choosing a COVID-19 vaccination site might be driven by anxiety and body vigilance
  68. Role of ICAM-1 in triple-negative breast cancer
  69. Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
  70. HLA-DRB5 promotes immune thrombocytopenia via activating CD8+ T cells
  71. Efficacy and factors of myofascial release therapy combined with electrical and magnetic stimulation in the treatment of chronic pelvic pain syndrome
  72. Efficacy of tacrolimus monotherapy in primary membranous nephropathy
  73. Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking
  74. FBXO45 levels regulated ferroptosis renal tubular epithelial cells in a model of diabetic nephropathy by PLK1
  75. Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns
  76. Alpha-lipoic acid upregulates the PPARγ/NRF2/GPX4 signal pathway to inhibit ferroptosis in the pathogenesis of unexplained recurrent pregnancy loss
  77. Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study
  78. CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway
  79. miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
  80. Immune response analysis of solid organ transplantation recipients inoculated with inactivated COVID-19 vaccine: A retrospective analysis
  81. The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
  82. Clinical efficacy of dexamethasone combined with isoniazid in the treatment of tuberculous meningitis and its effect on peripheral blood T cell subsets
  83. Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis
  84. Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
  85. Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL2
  86. Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
  87. Risk factors of postoperative airway obstruction complications in children with oral floor mass
  88. Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction
  89. Physical activity and mental health trends in Korean adolescents: Analyzing the impact of the COVID-19 pandemic from 2018 to 2022
  90. Evaluating anemia in HIV-infected patients using chest CT
  91. Ponticulus posticus and skeletal malocclusion: A pilot study in a Southern Italian pre-orthodontic court
  92. Causal association of circulating immune cells and lymphoma: A Mendelian randomization study
  93. Assessment of the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals on treating renal fibrosis: A systematic review and meta-analysis
  94. Comprehensive landscape of integrator complex subunits and their association with prognosis and tumor microenvironment in gastric cancer
  95. New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: A drug Mendelian randomization study
  96. Population pharmacokinetics of meropenem in critically ill patients
  97. Comparison of the ability of newly inflammatory markers to predict complicated appendicitis
  98. Comparative morphology of the cruciate ligaments: A radiological study
  99. Immune landscape of hepatocellular carcinoma: The central role of TP53-inducible glycolysis and apoptosis regulator
  100. Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study
  101. SHP-1 mediates cigarette smoke extract-induced epithelial–mesenchymal transformation and inflammation in 16HBE cells
  102. Acute hyper-hypoxia accelerates the development of depression in mice via the IL-6/PGC1α/MFN2 signaling pathway
  103. The GJB3 correlates with the prognosis, immune cell infiltration, and therapeutic responses in lung adenocarcinoma
  104. Physical fitness and blood parameters outcomes of breast cancer survivor in a low-intensity circuit resistance exercise program
  105. Exploring anesthetic-induced gene expression changes and immune cell dynamics in atrial tissue post-coronary artery bypass graft surgery
  106. Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
  107. Analysis of the risk factors of the radiation-induced encephalopathy in nasopharyngeal carcinoma: A retrospective cohort study
  108. Reproductive outcomes in women with BRCA 1/2 germline mutations: A retrospective observational study and literature review
  109. Evaluation of upper airway ultrasonographic measurements in predicting difficult intubation: A cross-section of the Turkish population
  110. Prognostic and diagnostic value of circulating IGFBP2 in pancreatic cancer
  111. Postural stability after operative reconstruction of the AFTL in chronic ankle instability comparing three different surgical techniques
  112. Research trends related to emergence agitation in the post-anaesthesia care unit from 2001 to 2023: A bibliometric analysis
  113. Frequency and clinicopathological correlation of gastrointestinal polyps: A six-year single center experience
  114. ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
  115. Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
  116. Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
  117. The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae
  118. Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
  119. Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study
  120. Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway
  121. Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population
  122. Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
  123. Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study
  124. Decreased BIRC5-206 promotes epithelial–mesenchymal transition in nasopharyngeal carcinoma through sponging miR-145-5p
  125. Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
  126. Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis
  127. Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures
  128. The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial
  129. Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
  130. Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
  131. Parental control attitudes over their pre-school children’s diet
  132. The role of auto-HSCT in extranodal natural killer/T cell lymphoma
  133. Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy
  134. Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin
  135. ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
  136. The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study
  137. The unusual location of primary hydatid cyst: A case series study
  138. Intraoperative changes in electrophysiological monitoring can be used to predict clinical outcomes in patients with spinal cavernous malformation
  139. Obesity and risk of placenta accreta spectrum: A meta-analysis
  140. Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
  141. NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages
  142. The effect of COVID-19 lockdown on admission rates in Maternity Hospital
  143. Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
  144. Luteolin alleviates cerebral ischemia/reperfusion injury by regulating cell pyroptosis
  145. Therapeutic role of respiratory exercise in patients with tuberculous pleurisy
  146. Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
  147. Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
  148. DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy
  149. Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients
  150. Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
  151. Ferroptosis-related prognostic model of mantle cell lymphoma
  152. Observation of choking reaction and other related indexes in elderly painless fiberoptic bronchoscopy with transnasal high-flow humidification oxygen therapy
  153. A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022
  154. The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study
  155. Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
  156. Role of COX6C and NDUFB3 in septic shock and stroke
  157. Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
  158. Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
  159. Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation
  160. Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
  161. Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients
  162. Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
  163. Risk factors for progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fracture
  164. Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke
  165. The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
  166. Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
  167. Detection of serum FOXM1 and IGF2 in patients with ARDS and their correlation with disease and prognosis
  168. Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
  169. Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
  170. Review Articles
  171. Cutaneous signs of selected cardiovascular disorders: A narrative review
  172. XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
  173. A narrative review on adverse drug reactions of COVID-19 treatments on the kidney
  174. Emerging role and function of SPDL1 in human health and diseases
  175. Adverse reactions of piperacillin: A literature review of case reports
  176. Molecular mechanism and intervention measures of microvascular complications in diabetes
  177. Regulation of mesenchymal stem cell differentiation by autophagy
  178. Molecular landscape of borderline ovarian tumours: A systematic review
  179. Advances in synthetic lethality modalities for glioblastoma multiforme
  180. Investigating hormesis, aging, and neurodegeneration: From bench to clinics
  181. Frankincense: A neuronutrient to approach Parkinson’s disease treatment
  182. Sox9: A potential regulator of cancer stem cells in osteosarcoma
  183. Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients
  184. Advanced neuroimaging and criminal interrogation in lie detection
  185. Maternal factors for neural tube defects in offspring: An umbrella review
  186. The chemoprotective hormetic effects of rosmarinic acid
  187. CBD’s potential impact on Parkinson’s disease: An updated overview
  188. Progress in cytokine research for ARDS: A comprehensive review
  189. Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
  190. NRXN1-related disorders, attempt to better define clinical assessment
  191. Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
  192. Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
  193. Iron in ventricular remodeling and aneurysms post-myocardial infarction
  194. Case Reports
  195. Sirolimus potentiated angioedema: A case report and review of the literature
  196. Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report
  197. Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman’s disease: A case report
  198. Complete heart block associated with hepatitis A infection in a female child with fatal outcome
  199. Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review
  200. Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
  201. Advancing prenatal diagnosis: Echocardiographic detection of Scimitar syndrome in China – A case series
  202. Outcomes and complications of hemodialysis in patients with renal cancer following bilateral nephrectomy
  203. Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy
  204. Recurrent opportunistic infections in a HIV-negative patient with combined C6 and NFKB1 mutations: A case report, pedigree analysis, and literature review
  205. Letter to the Editor
  206. Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
  207. Erratum
  208. Erratum to “Bladder-embedded ectopic intrauterine device with calculus”
  209. Retraction
  210. Retraction of “XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis”
  211. Corrigendum
  212. Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”
  213. Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
  214. Special Issue The evolving saga of RNAs from bench to bedside - Part II
  215. Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma
  216. Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
  217. Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment
  218. Special Issue Advancements in oncology: bridging clinical and experimental research - Part I
  219. Ultrasound-guided transperineal vs transrectal prostate biopsy: A meta-analysis of diagnostic accuracy and complication rates
  220. Assessment of diagnostic value of unilateral systematic biopsy combined with targeted biopsy in detecting clinically significant prostate cancer
  221. SENP7 inhibits glioblastoma metastasis and invasion by dissociating SUMO2/3 binding to specific target proteins
  222. MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
  223. Analysis of postoperative complications in bladder cancer patients
  224. Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study
  225. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part I
  226. Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma
  227. Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer
  228. Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis
Jetzt anmelden und 20% sparen
Institutioneller Zugang
Wie funktioniert Authentifizierung?
Haben Sie eine Idee, wie wir unsere Website verbessern können?
Bitte schreiben Sie uns.
© 2025 De Gruyter Brill
Heruntergeladen am 25.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/med-2024-0988/html
Button zum nach oben scrollen