Home Medicine Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
Article Open Access

Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea

  • SeungCheor Lee , Yeowool Lee , Saengryeol Park , So-Youn Park and In-Hwan Oh EMAIL logo
Published/Copyright: December 31, 2024
Download Article (PDF)
Open Medicine
From the journal Open Medicine Volume 19 Issue 1

Abstract

Aim

The World Health Organization’s recommendation of at least 150 min of physical activity per week is important for increasing the lifespan of persons with disabilities (PWDs).

Methods

Conduct a survival analysis to examine the relationship between physical activity and mortality using cohort data from the National Health Insurance Service in South Korea from 2017 to 2021. The survival analysis included 259,146 PWDs, with a maximum follow-up of 57 months, and adjustments for covariates, including physical activity level, comorbidities, smoking, and alcohol consumption.

Results

People who exercised >150 min weekly had a lower risk of death compared to those who exercised less (adjusted hazard ratio [AHR]: 0.727, 95% confidence interval [CI]: 0.674–0.784). The risk of death increased with increasing age (AHR: 1.08, 95% CI: 1.077–1.083), smokers had a higher risk of death than non-smokers (AHR: 1.487, 95% CI: 1.396–1.583), and the risk of death increased with increasing Charlson comorbidity index scores (AHR: 1.228, 95% CI: 1.22–1.237).

Conclusion

Even after adjusting for socioeconomic and other risk factors, PWDs who are physically inactive have a higher risk of death. Customized physical activity policies for PWDs are needed to reduce health inequities.

Keywords: physical activity; mortality; survival analysis; persons with disabilities; Republic of Korea

1 Introduction

The World Health Organization (WHO) recommends at least 150 min of physical activity per week [1]. However, according to a study that evaluated the participation of persons with disabilities (PWDs) in physical activity, 60% did not regularly meet this goal [2]. Another study reported that PWDs, compared with those without disabilities, were less likely to perform physical activity and had a higher risk of obesity, and only 39.4% of PWDs in South Korea had a body mass index within the normal range [3]. Consequently, PWDs are more likely to be at higher risk of cardiovascular disease, which can lead to premature death [4]. We already know that physical activity is beneficial to health, but there is a disparity between persons without disabilities and PWDs, and this study aims to increase physical activity among PWDs.

The most noticeable change in the recently revised WHO Physical Activity Guidelines is the warning that people of all ages, including children and adolescents, should not be sedentary [5]. In previous guidelines, the WHO suggested a minimum activity duration of 10 min for a single session, but the revised guidelines emphasize steady movement with no limit to physical activity. For your health, achieving the minimum physical activity recommendations in the guideline is most important. PWDs and prolonged sedentary behaviors, including those at high risk, pregnant women, and people with chronic diseases, should aim to achieve the same minimum of 150 min of physical activity per week as people without disabilities, and strength training is recommended at least twice a week for each body part [5]. The new revised guidelines recognize that every movement counts, and staying active is important, including taking the stairs or doing chores, to maintain health. Scientific research on the adverse health consequences of prolonged sitting is also cited [6].

Health inequality of individuals with disabilities is conceptualized as “a health gap between groups or within a group of persons with disabilities that arises as a result of unequal access to health and medical services as a result of deprivation of the right to health of persons with disabilities and continuous social discrimination against persons with disabilities, and the absence of a system to prevent and manage secondary disabilities” [7]. Therefore, PWDs are relatively vulnerable and likely to develop chronic diseases at an early age [8]. Previous studies have suggested that PWDs have a higher prevalence of chronic diseases and are more likely to have serious complications or reduced life expectancy [9]. Aside from comorbid diseases, the other main factors affecting mortality rates are health risk factors such as smoking, drinking, and physical inactivity [10]. A lack of physical activity is associated with premature death and can increase mortality in the general population [10]. A recent study reported that sufficient physical activity is related to even lower coronavirus disease-related infections and mortality [11]. However, the relationship between physical activity and mortality among PWDs has not been extensively studied.

Socioeconomic factors such as occupation, education level, and income levels are closely related to mortality [12]. In particular, minority groups may have a lower socioeconomic status than other groups because of social discrimination. In addition, the socioeconomic gap between individuals with and without disabilities may be further widened owing to limitations caused by physical or mental impairments resulting from interactions with the social environment [12]. When researching the health of PWDs, studies analyzing factors related to physical activity and death should consider both health and socioeconomic factors. Therefore, understanding and developing associations between health and socioeconomic risk factors when designing health promotion programs for PWDs may be effective in reducing mortality risk.

Until now, no studies have analyzed the relationship between health risk factors, socioeconomic factors, and mortality and focused on the amount of physical activity among PWDs in Korea. Therefore, this study investigated the association between physical activity and mortality using data from the National Health Insurance Service (NHIS), which is representative of the Korean population.

2 Methods

2.1 Data source and participants

This research is an analytical study using cohort data and examined factors affecting mortality risk among PWDs using data from the NHIS, which is representative of South Korea. We used health examination records from 2017 to 2021, with a maximum follow-up period of 57 months for deaths in survival analysis. The NHIS covers approximately 97% of the South Korean population and provides mandatory health checkups every 2 years [13]. In addition, the health insurance data include information on medical treatments and health checkups, which encompasses health behaviors such as smoking, drinking, and physical activity. For this study, of 2,970,808 people with registered disabilities as of September 30, 2021, we selected 1,757,322 people who participated in health checkups provided by the NHIS. Of these, 1,498,176 were excluded because of missing data on the amount of physical activity, region of residence, income quintile, and smoking and drinking status. Therefore, 251,995 people with non-terminal disabilities and 7,151 people with terminal disabilities were selected as final participants (Figure 1). The NHIS data record patient demographics, consultation history, diagnosis history, prescriptions, and more of people who receive health screenings in the country. The dataset analyzed for this study was provided by the NHIS public database (NHIS-2022-1-223). The dataset is fee-based and was provided to the authors after a reasonable application process and approval by the NHIS. Additional access to the dataset is available with permission from the NHIS.

Figure 1 Flowchart of the selection process for analysis.
Figure 1

Flowchart of the selection process for analysis.

2.2 Definition of study variables

2.2.1 PWDs

In South Korea, PWDs are registered with the Ministry of Health and Welfare and diagnosed by a doctor under the Disability Welfare Act, to measure the degree and type of disability. Disabilities were classified based on the severity as mild or severe; the disability type was classified as a legally prescribed physical disability, disability due to brain lesions, hearing disability, visual disability, speech disability, intellectual disability, autistic disorder, mental disorder, cardiac dysfunction, kidney dysfunction, respiratory dysfunction, hepatic dysfunction (or liver dysfunction), facial disfigurement, intestinal fistula/urinary fistula, or epilepsy [14].

2.2.2 Physical activity

Physical activity levels were categorized into two groups based on WHO guidelines as follows: the physical inactivity group (i.e., less than 150 min of physical activity per week) and the physical activity attainment group (i.e., more than 150 min of physical activity per week). Physical activity was measured using a self-report questionnaire based on the NHIS health checkup information. Moderate-intensity physical activity was measured using the following question: “During the last week, how many times a week and for how many hours a day did you engage in physical activity at a moderate level for more than 10 min (e.g., fast walking, doubles tennis, riding bicycle, and cleaning)?” High-intensity physical activity was assessed using the following question: “During the last week, how many days a week and for how many hours a day did you engage in physical activity at a vigorous level for more than 10 min (e.g., running, aerobic, fast riding a bicycle)?” Physical activity level was classified as either more or less than 150 min per week [1]. Physical activity was defined based on the physical activity guidelines of at least 150 min of moderate-intensity or the equivalent high-intensity physical activity per week, where 1 min of high-intensity physical activity is equivalent to 2 min of moderate-intensity physical activity. This classification has been widely used in the literature [15].

2.2.3 Covariates

We adjusted for covariates associated with mortality, including physical activity, sex, age, health insurance type, income quintile, reemployment status, smoking status, drinking status, comorbidities, and region of residence. Health insurance types were categorized as medical aid, local residents, and employed. Income levels were categorized as medical aid, 1, 2, 3, 4, and 5, with higher numbers indicating a higher income. Medical aid was provided as part of basic living assistance, and people with medical aid did not pay insurance premiums.

Reemployment referred to being reemployed as a worker in the same region. Residential areas were categorized by the city and province in South Korea. The cities were Seoul, Busan, Incheon, Gwangju, Daegu, Daejeon, Ulsan, and Sejong, and the provinces were Gangwon, Gyeonggi, Chungcheongnam, Chungcheongbuk, Gyeongsangnam, Gyeongsangbuk, Jeollanam, Jeollabuk, and Jeju.

Comorbidities were comprehensively evaluated using the Charlson comorbidity index (CCI), which can be applied to various diseases. The CCI uses administrative data as a data source and is widely used in research because it reflects the severity of comorbidities. Comorbidities refer to other diseases the patient has, aside from the main diagnosis (e.g., diabetes and hypertension). CCI scores were classified using the average scores based on the medical records.

Smoking and alcohol drinking statuses were assessed using a self-report questionnaire. Smoking status was measured using the question, “Have you ever smoked over five packs of cigarettes (100 pieces) in your lifetime?” Drinking status was assessed using the question, “How many times do you drink alcohol per week?”

2.3 Statistical analyses

The chi-squared test and survival analyses were used to analyze the data. Statistical analyses were performed using SAS version 9.4 (SAS Institute Inc., Cary, NC, USA), and the significance level for all statistical tests was set at 5%. The chi-squared test was performed to assess the characteristics of PWDs related to physical activity. Survival analysis was performed to analyze the factors affecting the mortality risk of PWDs. The Cox proportional hazard model was used by setting survival and death as dependent variables. The study’s maximum follow-up period was 57 months.

  1. Informed consent: Since de-identified data were used, the requirement for informed consent was waived.

  2. Ethical approval: This study was approved by the Institutional Review Board of Chonnam National University (no. 1040198-210923-HR-146-01).

3 Results

Overall, 251,995 patients with disabilities lived and 7,151 died. In terms of severity, 80.2% of disabilities were classified as mild and 19.8% as severe in the non-physical activity group, with a 1.8% higher prevalence of severe disabilities compared to that in the physical activity group. In the non-physically active group, 68.4% were men and 31.6% were women, with an approximately 1.82 times higher prevalence of women compared to that in the physical activity group. The mean ages of the physically inactive and active groups were 64.5 (±13.20) and 58.9 (±12.34) years, respectively. Income levels were three times higher in the non-physically active group than in the physically active group, with a medical aid prevalence of 2.7%. The mean CCI score was 5.7 (±3.24) for the non-physical activity group and 5 (±3.21) for the physical activity group (Table 1).

Table 1

Socioeconomic characteristics according to physical activity of persons with disabilities

Physical activity (150 min per week) p
<150 ≥150
n (mean) % (SD) n (mean) % (SD)
Severity of disability Mild 158,866 80.2% 50,052 82.0% <0.001
Severe 39,243 19.8% 10,985 18.0%
Sex Male 135,500 68.4% 50,465 82.7% <0.001
Female 62,609 31.6% 10,572 17.3%
Age (years) 64.6 ± 13.20 58.9 ± 12.34 <0.001
Health insurance type Medical aid 5,349 2.7% 561 0.9% <0.001
Region (no work) 26,401 13.3% 5,040 8.3%
Workplace 166,359 84.0% 55,436 90.8%
Income quintile Medical aid 5,349 2.7% 561 0.9% <0.001
1 46,483 23.5% 11,228 18.4%
2 35,932 18.1% 11,712 19.2%
3 33,614 17.0% 10,841 17.8%
4 37,199 18.8% 12,717 20.8%
5 39,532 20.0% 13,978 22.9%
Reemployment No 196,143 99.0% 60,458 99.1% 0.223
Yes 1,966 1.0% 579 0.9%
Smoking No 153,052 77.3% 45,227 74.1% <0.001
Yes 45,057 22.7% 15,810 25.9%
Drinking No 145,546 73.5% 38,565 63.2% <0.001
Yes 52,563 26.5% 22,472 36.8%
Charlson comorbidity index score 5.7 ± 3.24 5.0 ± 3.21 <0.001
Survival 191,765 76.1% 60,230 23.9% <0.001
Death 6,344 88.7% 807 11.3%
Total 198,109 76.4% 61,037 23.6% <0.001

Note. n: number; SD: standard deviation. Adjusting: disability types, region of residence.

The only case in which people with hepatic dysfunction (or liver dysfunction) exercised more than 150 min per week was among the disabled group (51.5%). The frequency of the disability type in participants who exercised for less than 150 min per week was as follows: autistic disorder, 52.7%; intestinal fistula/urinary fistula dysfunction, 55.7%; visual disability, 56.5%; facial disfigurement, 57.1%; speech disability, 57.8%; hearing disability, 58.8%; physical disability, 58.9%; cardiac dysfunction, 59.3%; kidney dysfunction, 61%; epilepsy dysfunction, 63.7%; brain lesion disability, 63.8%; respiratory dysfunction, 65.8%; intellectual disability, 67.5%; and mental disorder, 71.2% (Table 2).

Table 2

Analysis of frequency according to disability types and physical activity

Physical activity (150 min per week) p
<150 ≥150
Variables n % n %
Disability types Physical disability 99,241 58.9% 36,119 41.1% <0.001
Disability of brain lesion 9,173 63.8% 2,219 36.2%
Visual disability 20,768 56.5% 6,804 43.5%
Hearing disability 45,456 58.8% 9,947 41.2%
Speech disability 1,279 57.8% 408 42.2%
Intellectual disorder (mental retardation) 9,121 67.5% 2,224 32.5%
Autistic disorder 514 52.7% 269 47.3%
Mental disorder 2,686 71.2% 542 28.8%
Kidney dysfunction 6,213 61.0% 1,388 39.0%
Cardiac dysfunction 350 59.3% 98 40.7%
Respiratory dysfunction 861 65.8% 139 34.2%
Hepatic dysfunction (or liver dysfunction) 930 48.5% 378 51.5%
Facial disfigurement 272 57.1% 132 42.9%
Intestinal fistular/urinary fistular dysfunction 877 55.7% 273 44.3%
Epilepsy dysfunction 368 63.7% 97 36.3%
Total 198,109 59.9% 61,037 40.1% <0.001

Note. n: number.

Survival analyses were performed to analyze factors affecting the mortality risk, and the maximum follow-up period was 4 years and 9 months. Those who exercised for more than 150 min per week had a 0.727 times (adjusted hazard ratio [AHR]) lower risk of death than that had by those who exercised less (95% confidence interval [CI]: 0.674–0.784). Females with a disability were 0.726 times (AHR) less likely to die than males (95% CI: 0.685–0.769), and the risk of death was 1.08 times (AHR) higher with increasing age (95% CI: 1.077–1.083). Higher-income quintiles were associated with a lower risk of death, with the 5th quintile having a 0.603-times (AHR) lower risk of death compared to the medical aid group (95% CI: 0.539–0.674). Regarding reemployment, employed patients had a 0.672-times (AHR) lower risk of death than that of unemployed patients (95% CI: 0.457–0.988). Smokers had a 1.487-times (AHR) higher risk of death (95% CI: 1.396–1.583) than that of non-smokers, and increasing CCI scores were linked to a 1.228-times (AHR) higher risk of death (95% CI: 1.22–1.237).

People with visual disabilities had a 1.444-times (AHR; 95% CI: 1.318–1.582) higher risk of death than people with physical disabilities. Likewise, people with hearing disabilities (AHR: 1.792; 95% CI: 1.679–1.913), hepatic dysfunction (AHR: 2.673; 95% CI: 2.115–3.378), speech disabilities (AHR: 2.973; 95% CI: 2.289–3.863), cardiac dysfunction (AHR: 3.003; 95% CI: 2.073–4.351), and brain lesion disabilities (AHR: 3.028; 95% CI: 2.778–3.301) had a higher risk of death. Those with kidney function disability (AHR: 3.457; 95% CI: 3.112–3.841), intellectual disability (AHR: 3.619; 95% CI: 2.899–4.517), intestinal fistula/urinary fistula (AHR: 3.631; 95% CI: 3.043–4.334), mental disability (AHR: 4.22; 95% CI: 3.328–5.351), epilepsy (AHR: 4.453; 95% CI: 2.721–7.29), and respiratory dysfunction (AHR: 5.321; 95% CI: 4.411–6.42) had a higher risk of death (Table 3).

Table 3

Survival analysis of mortality risk by physical activity in persons with disabilities

Univariate model Multivariate model
Variables Crude HR 95% CI Adjusted HR 95% CI
Physical activity (150 min a week) <150 1 1
≥150 0.416 0.386–0.447 0.727 0.674–0.784
Disability types Physical disability 1 1
Disability of brain lesion 5.205 4.793–5.654 3.028 2.778–3.301
Visual disability 1.509 1.378–1.653 1.444 1.318–1.582
Hearing disability 4.392 4.143–4.656 1.792 1.679–1.913
Speech disability 2.189 1.686–2.841 2.973 2.289–3.863
Intellectual disorder (mental retardation) 0.532 0.432–0.656 3.619 2.899–4.517
Autistic disorder 0 0–2.59 0.001 0–2.358
Mental disorder 1.806 1.439–2.266 4.22 3.328–5.351
Kidney dysfunction 6.173 5.636–6.761 3.457 3.112–3.841
Cardiac dysfunction 3.848 2.667–5.551 3.003 2.073–4.351
Respiratory dysfunction 7.528 6.295–9.003 5.321 4.411–6.42
Hepatic dysfunction (or liver dysfunction) 3.444 2.731–4.343 2.673 2.115–3.378
Facial disfigurement 0.575 0.216–1.533 1.517 0.568–4.047
Intestinal fistula/urinary fistula dysfunction 8.604 7.225–10.246 3.631 3.043–4.334
Epilepsy dysfunction 1.919 1.173–3.138 4.453 2.721–7.29
Severity of disability Mild 1 1
Severe 0.945 0.894–1 0.856 0.799–0.917
Sex Male 1 1
Female 1.056 1.001–1.113 0.726 0.685–0.769
Age Per year 1.098 1.096–1.101 1.08 1.077–1.083
Income quintile Medical aid 1 1
1 0.238 0.213–0.266 0.509 0.454–0.57
2 0.219 0.195–0.245 0.499 0.444–0.562
3 0.239 0.213–0.268 0.633 0.562–0.712
4 0.233 0.208–0.261 0.62 0.552–0.697
5 0.384 0.345–0.428 0.603 0.539–0.674
Reemployment No 1 1
Yes 0.491 0.334–0.722 0.672 0.457–0.988
Smoking No 1 1
Yes 0.726 0.685–0.769 1.487 1.396–1.583
Drinking No 1 1
Yes 0.449 0.422–0.478 0.945 0.883–1.012
CCI score M (SD) 1.347 1.339–1.354 1.228 1.22–1.237

Note. CCI: Charlson comorbidity index; CI: confidence interval; HR: hazard ratio; M: mean; SD: standard deviation. Adjusting: region of residence.

4 Discussion

In this study, only 40.1% of the PWDs met the WHO guidelines of more than 150 min of physical activity per week. The 2020 revised WHO guidelines set the recommended level of physical activity for PWDs at 150 min or more per week, which was the same for persons without disabilities [5]. This study also found that among PWDs, those with higher levels of physical activity had lower mortality rates (crude hazard ratio [CHR]: 0.416, 95% CI: 0.674–0.784). Therefore, the high mortality rates of those with disabilities could be partly related to low physical activity. The relationship between physical activity levels and death was also significant when adjusting for other factors related to physical activity levels, such as disability severity, disability type, income level, smoking, and alcohol consumption (AHR: 0.727, 95% CI: 0.674–0.784). These results therefore indicate that policies may be needed to increase physical activity levels and consequently lower mortality among PWDs. Regular physical activity can help improve health, maintain physical function, and improve the quality of life with little time and cost [16].

Meanwhile, a study on exercise participation among PWDs found that only 40% of PWDs exercise regularly [2]. Most participants who do not exercise regularly are severely disabled and are highly constrained by the lack of desired programs and a fear of injury during exercise. Therefore, in the future, customized exercise programs for PWDs should be developed to ensure safety by considering the risks that may arise from various disability characteristics. In addition, compensation for exercise differences by income is lacking [17], and this needs to be complemented by policy.

This study only included PWDs who participated in health screenings and reported their physical activity. Therefore, PWDs who participated in health screenings and indicated their physical activity levels are assumed to have relatively high levels of health [18]. Caution should be exercised when considering groups of PWDs who do not routinely receive health checks or indicate their physical activity levels, as lower actual physical activity levels may have a greater impact on mortality.

Another notable finding is the relationship between other health risk behaviors and mortality. In another study, smoking contributed to less physical activity in PWDs [19]. In this survival analysis, when only smoking was considered, smoking was not significantly associated with mortality (CHR: 0.726, 95% CI: 0.685–0.769), but when other factors were adjusted, smoking increased the risk of death (AHR: 1.487, 95% CI: 1.396–1.583). Introducing policies that simultaneously change health behaviors, such as combined interventions that improve smoking and physical activity, could further reduce mortality.

PWDs have poorer health behaviors than people without disabilities owing to their circumstances [9]. PWDs have difficulty participating in exercise and physical activities because of issues with accessibility, economic problems, physical problems, professional leadership problems, and lack of laws and institutional devices [16]. PWDs are more likely to be physically inactive and obese and have diabetes, metabolic syndrome, and lipid disorders, all of which are risk factors for cardiovascular diseases [10]. High levels of physical activity are associated with various health benefits. Physical activity prevents cardiovascular diseases, such as heart disease, high blood pressure, and cerebrovascular disease, and chronic diseases, such as diabetes and cancer, by enhancing cardiopulmonary function and muscle strength [18]. Furthermore, regular participation in physical activity can help maintain independence and prevent secondary health problems caused by disability [20]. These findings emphasize the need to develop and implement policies to increase physical activity levels among PWDs by making the appropriate environments.

In addition, the ability of PWDs to be physically active may vary depending on the type and severity of their disability. For example, the types of physical activity performed by the groups with respiratory and visual impairments differ, and the ability to perform physical activity vary, even in those with severe and mild disabilities [21]. Therefore, to ensure an appropriate level of physical activity among those with disabilities, developing a program tailored to the type and degree of disability is necessary.

A limitation of this study was that owing to limited data, the role of sedentary behavior, which is expected to have increased during the pandemic, was not included in the physical activity questionnaire. Furthermore, although the WHO has defined sedentary behavior, whether moderate-intensity activity is included is unclear. Future studies should include these variables to measure physical activity.

5 Conclusion

This study using data representative of the population of South Korea demonstrated that the low level of physical activity among the group with disabilities is closely related to high mortality levels, after adjusting for other factors that may be related to physical activity and mortality. Males; older adults; PWDs such as respiratory, epilepsy, and mental disorders; people with a low income; unemployed patients; smokers, and patients with high CCI scores are at higher risk of death. Our study confirmed that physical inactivity affects mortality after adjusting for CCI scores, smoking, and alcohol consumption among PWDs. Thus, it is important to increase physical activity to prevent complications and increase longevity in PWDs. Therefore, it is necessary to develop customized exercise support policies that consider disability-specific characteristics and severity for populations at high risk of mortality.

Abbreviations

AHR

adjusted hazard ratio

CCI

Charlson comorbidity index

CI

confidence interval

NHIS

National Health Insurance Service

PWDs

persons with disabilities

WHO

World Health Organization

tel: +82-2-961-2304

Acknowledgments

The authors thank the Korea National Rehabilitation Center and Kyung Hee University Medical School and Chonnam National University for supporting this study.

  1. Funding information: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI21C2122).

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and consented to its submission to the journal, reviewed all the results, and approved the final version of the manuscript. SL, YL, and SP drafted the manuscript and performed the statistical analysis; S-YP and I-HO conceived the study, participated in its design and coordination, and helped to draft the manuscript.

  3. Conflict of interest: Authors state no conflict of interest.

  4. Data availability statement: This study used the public database (NHIS-2022-1-223) of the National Health Insurance Service. Additional access to the datasets may be granted upon permission from the National Health Insurance Service.

References

[1] World Health Organization. Global status report on noncommunicable diseases 2014 [Internet]. 2014. [cited 2023 Oct 21]. https://www.who.int/publications/i/item/9789241564854.Search in Google Scholar

[2] Kim S, Kim J. Comparison of participation in exercise, attitude to exercise, and exercise barriers of persons with disabilities according to disability characteristics. Korea J Sports Sci. 2021;30(4):37–48.10.35159/kjss.2021.8.30.4.37Search in Google Scholar

[3] Korea Institute for Health and Social Affairs. Survey on the status of disabled, 2017. [cited 2024 Sep 3]. http://www.mohw.go.kr/react/jb/sjb030301vw.jsp?PAR_MENU_ID=03&MENU_ID=032901&CONT_SEQ=345972.Search in Google Scholar

[4] National Rehabilitation Center. 2017 health care project for the disabled, 2018. [cited 2024 Oct 1]. http://www.nrc.go.kr/research/board/boardView.do?bn=newsView&fno=37&menu_cd=05_02_00_01&no=15732&bno=15732&board_id=NRC_NOTICE_BOARD.Search in Google Scholar

[5] World Health Organization. WHO guidelines on physical activity and sedentary behaviour. [cited 2024 Oct 10]. https://www.who.int/publications/i/item/9789240015128.Search in Google Scholar

[6] US Department of Health and Human Services. Physical activity guidelines advisory committee scientific report. [cited 2024 May 1]. https://health.gov/sites/default/files/2019-09/PAG_Advisory_Committee_Report.pdf.Search in Google Scholar

[7] Shin YR, Kim CS, Cho HJ, Yoo DC. Exploring for the conceptualization of health inequality of people with disabilities. J Crit Soc Policy. 2017;56(8):205–36.Search in Google Scholar

[8] Korea Disabled People’s Development Institute. The disabled white book. 2017. [cited 2024 Oct 27]. https://www.koddi.or.kr/data/research01_view.jsp?brdNum=7404293&brdTp=&searchParamUrl=brdType%3DRSH%26amp%3BbrdRshYnData%3Ddata%26amp%3Bpage%3D1%26amp%3BpageSize%3D20.Search in Google Scholar

[9] Kim JY, Kang MW, Seo WY, Lee JW. Chronic diseases, health behaviors, and mortality in persons with disabilities: an analysis of the National Health Insurance Service-Health screening (NHIS-HEALS) database. Health Soc Welf Rev. 2020;40(2):121–50.Search in Google Scholar

[10] Durstine JL, Gordon B, Wang Z, Luo X. Chronic disease and the link to physical activity. J Sport Health Sci. 2013;2(1):3–11.10.1016/j.jshs.2012.07.009Search in Google Scholar

[11] Park S, Kim H, Park SY, Oh IH. Pre-pandemic physical activity as a predictor of infection and mortality associated with COVID-19: Evidence from the National Health Insurance Service. Front Public Health. 2023;11:1072198.10.3389/fpubh.2023.1072198Search in Google Scholar PubMed PubMed Central

[12] Korea Institute for Health and Social Affairs. The multiple disparity of people with disabilities in Korea and the response of social policies. 2020. [cited 2024 Sep 20]. http://repository.kihasa.re.kr/handle/201002/37242.Search in Google Scholar

[13] Lee J, Lee JS, Park SH, Shin SA, Kim K. Cohort profile: The National Health Insurance Service–National Sample Cohort (NHIS-NSC), South Korea. Int J Epidemiol. 2017;46(2):e15.10.1093/ije/dyv319Search in Google Scholar PubMed

[14] Korea Ministry of Health and Welfare. Disability Rating Criteria, 2012. [cited 2024 Oct 4]. http://www.mohw.go.kr/react/jb/sjb030301vw.jsp?PAR_MENU_ID=03&MENU_ID=0320&CONT_SEQ=177408.Search in Google Scholar

[15] Park S, Park SY, Cheong HK, Oh IH. Moderate-to-vigorous physical activity and risk of all-cause mortality in people with anxiety disorders in South Korea. Int J Sport Exerc Psychol. 2023;21(2):217–29.10.1080/1612197X.2022.2066708Search in Google Scholar

[16] Kim JT. Study on policy to improve the participation in sports for all of people with disabilities. Korean J Phys Educ. 2016;55:763–71.Search in Google Scholar

[17] Park JY. The actual status of participation of the elderly with disabilities in sports for all and invigoration of their participation. Korea J Sports Sci. 2020;29:1–14.10.35159/kjss.2020.10.29.5.1Search in Google Scholar

[18] Korea Institute for Health and Social Affairs. Establishment of an efficient management system for advanced outcome of the National Health Screening Policy, 2009. [cited 2024 May 15]. https://khis-primo.hosted.exlibrisgroup.com/permalink/f/mltik9/82KHU_ALMA21116241780004426.Search in Google Scholar

[19] Lee SC, Cheong HK, Park S, Park SY, Oh IH. Differences in physical activity levels by sociodemographic and health risk factors among persons with disabilities in South Korea. Asia-Pacific J Public Health. 2024;36(5):478–85.10.1177/10105395241256158Search in Google Scholar PubMed

[20] Kim KS, Koo KM. Analysis of motivation for physical activity participation in individuals with disabilities: A systematic review. Korea J Sports Sci. 2017;26:285–95.10.35159/kjss.2017.12.26.6.285Search in Google Scholar

[21] Park J. The acceptance of a disability and the life satisfaction of individuals with severe physical disabilities. Korean J Phys Mult Health Disabil. 2015;58(1):1–28.10.20971/kcpmd.2015.58.1.1Search in Google Scholar
Received: 2024-08-25
Revised: 2024-11-07
Accepted: 2024-11-25
Published Online: 2024-12-31

© 2024 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Articles in the same Issue

  1. Research Articles
  2. EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway
  3. STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
  4. Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
  5. The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma
  6. METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
  7. Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
  8. Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty
  9. Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
  10. Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma
  11. Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue
  12. Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
  13. Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease
  14. METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients
  15. Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis
  16. Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay
  17. Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity
  18. Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound
  19. Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement
  20. miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization
  21. The analyses of human MCPH1 DNA repair machinery and genetic variations
  22. Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
  23. Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma
  24. Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
  25. The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
  26. Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis
  27. Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
  28. Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer
  29. Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke
  30. The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
  31. Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study
  32. Lactate dehydrogenase to albumin ratio is associated with in-hospital mortality in patients with acute heart failure: Data from the MIMIC-III database
  33. CD36-mediated podocyte lipotoxicity promotes foot process effacement
  34. Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
  35. FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
  36. Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
  37. Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
  38. Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition
  39. Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy
  40. Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction
  41. High SEC61A1 expression predicts poor outcome of acute myeloid leukemia
  42. Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
  43. Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway
  44. Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
  45. Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
  46. Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
  47. Clinical analysis of incomplete rupture of the uterus secondary to previous cesarean section
  48. Abnormal sleep duration is associated with sarcopenia in older Chinese people: A large retrospective cross-sectional study
  49. No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study
  50. Identification and validation of autophagy-related genes in SSc
  51. Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming
  52. Evaluation of quality of life in patients with schizophrenia: An inpatient social welfare institution-based cross-sectional study
  53. The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
  54. Compilation of a self-management assessment scale for postoperative patients with aortic dissection
  55. Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
  56. Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
  57. Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2
  58. Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
  59. High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression
  60. Factors influencing cardiovascular system-related post-COVID-19 sequelae: A single-center cohort study
  61. HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis
  62. Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
  63. Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
  64. ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
  65. Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
  66. The role of enhanced expression of Cx43 in patients with ulcerative colitis
  67. Choosing a COVID-19 vaccination site might be driven by anxiety and body vigilance
  68. Role of ICAM-1 in triple-negative breast cancer
  69. Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
  70. HLA-DRB5 promotes immune thrombocytopenia via activating CD8+ T cells
  71. Efficacy and factors of myofascial release therapy combined with electrical and magnetic stimulation in the treatment of chronic pelvic pain syndrome
  72. Efficacy of tacrolimus monotherapy in primary membranous nephropathy
  73. Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking
  74. FBXO45 levels regulated ferroptosis renal tubular epithelial cells in a model of diabetic nephropathy by PLK1
  75. Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns
  76. Alpha-lipoic acid upregulates the PPARγ/NRF2/GPX4 signal pathway to inhibit ferroptosis in the pathogenesis of unexplained recurrent pregnancy loss
  77. Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study
  78. CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway
  79. miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
  80. Immune response analysis of solid organ transplantation recipients inoculated with inactivated COVID-19 vaccine: A retrospective analysis
  81. The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
  82. Clinical efficacy of dexamethasone combined with isoniazid in the treatment of tuberculous meningitis and its effect on peripheral blood T cell subsets
  83. Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis
  84. Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
  85. Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL2
  86. Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
  87. Risk factors of postoperative airway obstruction complications in children with oral floor mass
  88. Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction
  89. Physical activity and mental health trends in Korean adolescents: Analyzing the impact of the COVID-19 pandemic from 2018 to 2022
  90. Evaluating anemia in HIV-infected patients using chest CT
  91. Ponticulus posticus and skeletal malocclusion: A pilot study in a Southern Italian pre-orthodontic court
  92. Causal association of circulating immune cells and lymphoma: A Mendelian randomization study
  93. Assessment of the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals on treating renal fibrosis: A systematic review and meta-analysis
  94. Comprehensive landscape of integrator complex subunits and their association with prognosis and tumor microenvironment in gastric cancer
  95. New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: A drug Mendelian randomization study
  96. Population pharmacokinetics of meropenem in critically ill patients
  97. Comparison of the ability of newly inflammatory markers to predict complicated appendicitis
  98. Comparative morphology of the cruciate ligaments: A radiological study
  99. Immune landscape of hepatocellular carcinoma: The central role of TP53-inducible glycolysis and apoptosis regulator
  100. Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study
  101. SHP-1 mediates cigarette smoke extract-induced epithelial–mesenchymal transformation and inflammation in 16HBE cells
  102. Acute hyper-hypoxia accelerates the development of depression in mice via the IL-6/PGC1α/MFN2 signaling pathway
  103. The GJB3 correlates with the prognosis, immune cell infiltration, and therapeutic responses in lung adenocarcinoma
  104. Physical fitness and blood parameters outcomes of breast cancer survivor in a low-intensity circuit resistance exercise program
  105. Exploring anesthetic-induced gene expression changes and immune cell dynamics in atrial tissue post-coronary artery bypass graft surgery
  106. Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
  107. Analysis of the risk factors of the radiation-induced encephalopathy in nasopharyngeal carcinoma: A retrospective cohort study
  108. Reproductive outcomes in women with BRCA 1/2 germline mutations: A retrospective observational study and literature review
  109. Evaluation of upper airway ultrasonographic measurements in predicting difficult intubation: A cross-section of the Turkish population
  110. Prognostic and diagnostic value of circulating IGFBP2 in pancreatic cancer
  111. Postural stability after operative reconstruction of the AFTL in chronic ankle instability comparing three different surgical techniques
  112. Research trends related to emergence agitation in the post-anaesthesia care unit from 2001 to 2023: A bibliometric analysis
  113. Frequency and clinicopathological correlation of gastrointestinal polyps: A six-year single center experience
  114. ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
  115. Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
  116. Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
  117. The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae
  118. Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
  119. Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study
  120. Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway
  121. Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population
  122. Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
  123. Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study
  124. Decreased BIRC5-206 promotes epithelial–mesenchymal transition in nasopharyngeal carcinoma through sponging miR-145-5p
  125. Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
  126. Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis
  127. Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures
  128. The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial
  129. Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
  130. Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
  131. Parental control attitudes over their pre-school children’s diet
  132. The role of auto-HSCT in extranodal natural killer/T cell lymphoma
  133. Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy
  134. Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin
  135. ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
  136. The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study
  137. The unusual location of primary hydatid cyst: A case series study
  138. Intraoperative changes in electrophysiological monitoring can be used to predict clinical outcomes in patients with spinal cavernous malformation
  139. Obesity and risk of placenta accreta spectrum: A meta-analysis
  140. Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
  141. NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages
  142. The effect of COVID-19 lockdown on admission rates in Maternity Hospital
  143. Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
  144. Luteolin alleviates cerebral ischemia/reperfusion injury by regulating cell pyroptosis
  145. Therapeutic role of respiratory exercise in patients with tuberculous pleurisy
  146. Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
  147. Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
  148. DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy
  149. Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients
  150. Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
  151. Ferroptosis-related prognostic model of mantle cell lymphoma
  152. Observation of choking reaction and other related indexes in elderly painless fiberoptic bronchoscopy with transnasal high-flow humidification oxygen therapy
  153. A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022
  154. The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study
  155. Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
  156. Role of COX6C and NDUFB3 in septic shock and stroke
  157. Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
  158. Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
  159. Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation
  160. Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
  161. Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients
  162. Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
  163. Risk factors for progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fracture
  164. Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke
  165. The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
  166. Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
  167. Detection of serum FOXM1 and IGF2 in patients with ARDS and their correlation with disease and prognosis
  168. Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
  169. Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
  170. Review Articles
  171. Cutaneous signs of selected cardiovascular disorders: A narrative review
  172. XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
  173. A narrative review on adverse drug reactions of COVID-19 treatments on the kidney
  174. Emerging role and function of SPDL1 in human health and diseases
  175. Adverse reactions of piperacillin: A literature review of case reports
  176. Molecular mechanism and intervention measures of microvascular complications in diabetes
  177. Regulation of mesenchymal stem cell differentiation by autophagy
  178. Molecular landscape of borderline ovarian tumours: A systematic review
  179. Advances in synthetic lethality modalities for glioblastoma multiforme
  180. Investigating hormesis, aging, and neurodegeneration: From bench to clinics
  181. Frankincense: A neuronutrient to approach Parkinson’s disease treatment
  182. Sox9: A potential regulator of cancer stem cells in osteosarcoma
  183. Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients
  184. Advanced neuroimaging and criminal interrogation in lie detection
  185. Maternal factors for neural tube defects in offspring: An umbrella review
  186. The chemoprotective hormetic effects of rosmarinic acid
  187. CBD’s potential impact on Parkinson’s disease: An updated overview
  188. Progress in cytokine research for ARDS: A comprehensive review
  189. Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
  190. NRXN1-related disorders, attempt to better define clinical assessment
  191. Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
  192. Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
  193. Iron in ventricular remodeling and aneurysms post-myocardial infarction
  194. Case Reports
  195. Sirolimus potentiated angioedema: A case report and review of the literature
  196. Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report
  197. Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman’s disease: A case report
  198. Complete heart block associated with hepatitis A infection in a female child with fatal outcome
  199. Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review
  200. Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
  201. Advancing prenatal diagnosis: Echocardiographic detection of Scimitar syndrome in China – A case series
  202. Outcomes and complications of hemodialysis in patients with renal cancer following bilateral nephrectomy
  203. Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy
  204. Recurrent opportunistic infections in a HIV-negative patient with combined C6 and NFKB1 mutations: A case report, pedigree analysis, and literature review
  205. Letter to the Editor
  206. Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
  207. Erratum
  208. Erratum to “Bladder-embedded ectopic intrauterine device with calculus”
  209. Retraction
  210. Retraction of “XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis”
  211. Corrigendum
  212. Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”
  213. Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
  214. Special Issue The evolving saga of RNAs from bench to bedside - Part II
  215. Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma
  216. Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
  217. Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment
  218. Special Issue Advancements in oncology: bridging clinical and experimental research - Part I
  219. Ultrasound-guided transperineal vs transrectal prostate biopsy: A meta-analysis of diagnostic accuracy and complication rates
  220. Assessment of diagnostic value of unilateral systematic biopsy combined with targeted biopsy in detecting clinically significant prostate cancer
  221. SENP7 inhibits glioblastoma metastasis and invasion by dissociating SUMO2/3 binding to specific target proteins
  222. MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
  223. Analysis of postoperative complications in bladder cancer patients
  224. Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study
  225. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part I
  226. Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma
  227. Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer
  228. Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis
https://doi.org/10.1515/med-2024-1118
Keywords for this article
physical activity; mortality; survival analysis; persons with disabilities; Republic of Korea
Creative Commons
BY 4.0

Articles in the same Issue

  1. Research Articles
  2. EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway
  3. STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
  4. Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
  5. The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma
  6. METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
  7. Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
  8. Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty
  9. Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
  10. Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma
  11. Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue
  12. Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
  13. Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease
  14. METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients
  15. Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis
  16. Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay
  17. Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity
  18. Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound
  19. Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement
  20. miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization
  21. The analyses of human MCPH1 DNA repair machinery and genetic variations
  22. Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
  23. Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma
  24. Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
  25. The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
  26. Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis
  27. Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
  28. Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer
  29. Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke
  30. The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
  31. Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study
  32. Lactate dehydrogenase to albumin ratio is associated with in-hospital mortality in patients with acute heart failure: Data from the MIMIC-III database
  33. CD36-mediated podocyte lipotoxicity promotes foot process effacement
  34. Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
  35. FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
  36. Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
  37. Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
  38. Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition
  39. Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy
  40. Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction
  41. High SEC61A1 expression predicts poor outcome of acute myeloid leukemia
  42. Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
  43. Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway
  44. Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
  45. Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
  46. Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
  47. Clinical analysis of incomplete rupture of the uterus secondary to previous cesarean section
  48. Abnormal sleep duration is associated with sarcopenia in older Chinese people: A large retrospective cross-sectional study
  49. No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study
  50. Identification and validation of autophagy-related genes in SSc
  51. Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming
  52. Evaluation of quality of life in patients with schizophrenia: An inpatient social welfare institution-based cross-sectional study
  53. The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
  54. Compilation of a self-management assessment scale for postoperative patients with aortic dissection
  55. Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
  56. Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
  57. Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2
  58. Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
  59. High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression
  60. Factors influencing cardiovascular system-related post-COVID-19 sequelae: A single-center cohort study
  61. HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis
  62. Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
  63. Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
  64. ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
  65. Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
  66. The role of enhanced expression of Cx43 in patients with ulcerative colitis
  67. Choosing a COVID-19 vaccination site might be driven by anxiety and body vigilance
  68. Role of ICAM-1 in triple-negative breast cancer
  69. Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
  70. HLA-DRB5 promotes immune thrombocytopenia via activating CD8+ T cells
  71. Efficacy and factors of myofascial release therapy combined with electrical and magnetic stimulation in the treatment of chronic pelvic pain syndrome
  72. Efficacy of tacrolimus monotherapy in primary membranous nephropathy
  73. Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking
  74. FBXO45 levels regulated ferroptosis renal tubular epithelial cells in a model of diabetic nephropathy by PLK1
  75. Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns
  76. Alpha-lipoic acid upregulates the PPARγ/NRF2/GPX4 signal pathway to inhibit ferroptosis in the pathogenesis of unexplained recurrent pregnancy loss
  77. Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study
  78. CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway
  79. miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
  80. Immune response analysis of solid organ transplantation recipients inoculated with inactivated COVID-19 vaccine: A retrospective analysis
  81. The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
  82. Clinical efficacy of dexamethasone combined with isoniazid in the treatment of tuberculous meningitis and its effect on peripheral blood T cell subsets
  83. Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis
  84. Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
  85. Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL2
  86. Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
  87. Risk factors of postoperative airway obstruction complications in children with oral floor mass
  88. Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction
  89. Physical activity and mental health trends in Korean adolescents: Analyzing the impact of the COVID-19 pandemic from 2018 to 2022
  90. Evaluating anemia in HIV-infected patients using chest CT
  91. Ponticulus posticus and skeletal malocclusion: A pilot study in a Southern Italian pre-orthodontic court
  92. Causal association of circulating immune cells and lymphoma: A Mendelian randomization study
  93. Assessment of the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals on treating renal fibrosis: A systematic review and meta-analysis
  94. Comprehensive landscape of integrator complex subunits and their association with prognosis and tumor microenvironment in gastric cancer
  95. New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: A drug Mendelian randomization study
  96. Population pharmacokinetics of meropenem in critically ill patients
  97. Comparison of the ability of newly inflammatory markers to predict complicated appendicitis
  98. Comparative morphology of the cruciate ligaments: A radiological study
  99. Immune landscape of hepatocellular carcinoma: The central role of TP53-inducible glycolysis and apoptosis regulator
  100. Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study
  101. SHP-1 mediates cigarette smoke extract-induced epithelial–mesenchymal transformation and inflammation in 16HBE cells
  102. Acute hyper-hypoxia accelerates the development of depression in mice via the IL-6/PGC1α/MFN2 signaling pathway
  103. The GJB3 correlates with the prognosis, immune cell infiltration, and therapeutic responses in lung adenocarcinoma
  104. Physical fitness and blood parameters outcomes of breast cancer survivor in a low-intensity circuit resistance exercise program
  105. Exploring anesthetic-induced gene expression changes and immune cell dynamics in atrial tissue post-coronary artery bypass graft surgery
  106. Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
  107. Analysis of the risk factors of the radiation-induced encephalopathy in nasopharyngeal carcinoma: A retrospective cohort study
  108. Reproductive outcomes in women with BRCA 1/2 germline mutations: A retrospective observational study and literature review
  109. Evaluation of upper airway ultrasonographic measurements in predicting difficult intubation: A cross-section of the Turkish population
  110. Prognostic and diagnostic value of circulating IGFBP2 in pancreatic cancer
  111. Postural stability after operative reconstruction of the AFTL in chronic ankle instability comparing three different surgical techniques
  112. Research trends related to emergence agitation in the post-anaesthesia care unit from 2001 to 2023: A bibliometric analysis
  113. Frequency and clinicopathological correlation of gastrointestinal polyps: A six-year single center experience
  114. ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
  115. Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
  116. Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
  117. The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae
  118. Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
  119. Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study
  120. Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway
  121. Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population
  122. Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
  123. Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study
  124. Decreased BIRC5-206 promotes epithelial–mesenchymal transition in nasopharyngeal carcinoma through sponging miR-145-5p
  125. Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
  126. Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis
  127. Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures
  128. The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial
  129. Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
  130. Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
  131. Parental control attitudes over their pre-school children’s diet
  132. The role of auto-HSCT in extranodal natural killer/T cell lymphoma
  133. Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy
  134. Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin
  135. ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
  136. The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study
  137. The unusual location of primary hydatid cyst: A case series study
  138. Intraoperative changes in electrophysiological monitoring can be used to predict clinical outcomes in patients with spinal cavernous malformation
  139. Obesity and risk of placenta accreta spectrum: A meta-analysis
  140. Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
  141. NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages
  142. The effect of COVID-19 lockdown on admission rates in Maternity Hospital
  143. Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
  144. Luteolin alleviates cerebral ischemia/reperfusion injury by regulating cell pyroptosis
  145. Therapeutic role of respiratory exercise in patients with tuberculous pleurisy
  146. Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
  147. Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
  148. DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy
  149. Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients
  150. Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
  151. Ferroptosis-related prognostic model of mantle cell lymphoma
  152. Observation of choking reaction and other related indexes in elderly painless fiberoptic bronchoscopy with transnasal high-flow humidification oxygen therapy
  153. A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022
  154. The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study
  155. Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
  156. Role of COX6C and NDUFB3 in septic shock and stroke
  157. Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
  158. Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
  159. Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation
  160. Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
  161. Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients
  162. Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
  163. Risk factors for progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fracture
  164. Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke
  165. The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
  166. Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
  167. Detection of serum FOXM1 and IGF2 in patients with ARDS and their correlation with disease and prognosis
  168. Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
  169. Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
  170. Review Articles
  171. Cutaneous signs of selected cardiovascular disorders: A narrative review
  172. XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
  173. A narrative review on adverse drug reactions of COVID-19 treatments on the kidney
  174. Emerging role and function of SPDL1 in human health and diseases
  175. Adverse reactions of piperacillin: A literature review of case reports
  176. Molecular mechanism and intervention measures of microvascular complications in diabetes
  177. Regulation of mesenchymal stem cell differentiation by autophagy
  178. Molecular landscape of borderline ovarian tumours: A systematic review
  179. Advances in synthetic lethality modalities for glioblastoma multiforme
  180. Investigating hormesis, aging, and neurodegeneration: From bench to clinics
  181. Frankincense: A neuronutrient to approach Parkinson’s disease treatment
  182. Sox9: A potential regulator of cancer stem cells in osteosarcoma
  183. Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients
  184. Advanced neuroimaging and criminal interrogation in lie detection
  185. Maternal factors for neural tube defects in offspring: An umbrella review
  186. The chemoprotective hormetic effects of rosmarinic acid
  187. CBD’s potential impact on Parkinson’s disease: An updated overview
  188. Progress in cytokine research for ARDS: A comprehensive review
  189. Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
  190. NRXN1-related disorders, attempt to better define clinical assessment
  191. Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
  192. Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
  193. Iron in ventricular remodeling and aneurysms post-myocardial infarction
  194. Case Reports
  195. Sirolimus potentiated angioedema: A case report and review of the literature
  196. Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report
  197. Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman’s disease: A case report
  198. Complete heart block associated with hepatitis A infection in a female child with fatal outcome
  199. Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review
  200. Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
  201. Advancing prenatal diagnosis: Echocardiographic detection of Scimitar syndrome in China – A case series
  202. Outcomes and complications of hemodialysis in patients with renal cancer following bilateral nephrectomy
  203. Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy
  204. Recurrent opportunistic infections in a HIV-negative patient with combined C6 and NFKB1 mutations: A case report, pedigree analysis, and literature review
  205. Letter to the Editor
  206. Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
  207. Erratum
  208. Erratum to “Bladder-embedded ectopic intrauterine device with calculus”
  209. Retraction
  210. Retraction of “XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis”
  211. Corrigendum
  212. Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”
  213. Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
  214. Special Issue The evolving saga of RNAs from bench to bedside - Part II
  215. Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma
  216. Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
  217. Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment
  218. Special Issue Advancements in oncology: bridging clinical and experimental research - Part I
  219. Ultrasound-guided transperineal vs transrectal prostate biopsy: A meta-analysis of diagnostic accuracy and complication rates
  220. Assessment of diagnostic value of unilateral systematic biopsy combined with targeted biopsy in detecting clinically significant prostate cancer
  221. SENP7 inhibits glioblastoma metastasis and invasion by dissociating SUMO2/3 binding to specific target proteins
  222. MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
  223. Analysis of postoperative complications in bladder cancer patients
  224. Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study
  225. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part I
  226. Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma
  227. Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer
  228. Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis
Sign up now to receive a 20% welcome discount
Institutional Access
How does access work?
Have an idea on how to improve our website?
Please write us.
© 2025 De Gruyter Brill
Downloaded on 25.12.2025 from https://www.degruyterbrill.com/document/doi/10.1515/med-2024-1118/html
Scroll to top button