Home Medicine Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study
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Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study

  • Sijin Li , Yawen Zhang , Haiying Li , Zeyang He , An Li , Jiao Yan and Daocheng Li EMAIL logo
Published/Copyright: December 12, 2024
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Open Medicine
From the journal Open Medicine Volume 19 Issue 1

Abstract

Purpose

This study compared the efficacy and safety of carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel in treating locally advanced cervical cancer (LACC).

Methods

A total of 48 patients were enrolled between January 2019 and December 2022 and randomly assigned to the experimental group (carboplatin + arsenic trioxide, n = 24) or control group (carboplatin + docetaxel, n = 24). The clinical efficacy, adverse reactions, and serological markers were analyzed.

Results

There was no significant difference in baseline characteristics or total effective rates between the two groups (72.22% vs 68.42%, P > 0.05). Both groups showed significant reductions in serum squamous cell carcinoma antigen levels after chemotherapy (P < 0.05), but no significant difference was observed between groups (6.00 ± 11.36 ng/mL vs 8.42 ± 12.17 ng/mL, P > 0.05). Additionally, there was no significant difference in the incidence of adverse reactions (P > 0.05).

Conclusion

Arsenic trioxide combined with carboplatin as a preoperative neoadjuvant chemotherapy for LACC is not worse than docetaxel combined with carboplatin in terms of short-term efficacy and safety during the treatment of LACC.

Keywords: locally advanced cervical cancer; arsenic trioxide; carboplatin; docetaxel; neoadjuvant chemotherapy

1 Introduction

Cervical cancer is the second most frequent common gynecological cancer in the world and is seriously harmful to the health of women with 500,000 new cases and hundred thousand deaths per year [1]. Locally advanced cervical cancer (LACC) accounts for about one third of all cervical cancer patients, while the disease is often diagnosed at an advanced stage. LACC is characterized by difficult surgery, easy recurrence, and metastasis. In spite of improvements in prevention and screening of LACC, approximately 67% of patients will have locally advanced stage and the 5-year survival rate is only 30–80% [2]. The spread of pelvic tumors to lymph nodes or distant metastasis is the main cause of poor prognosis in LACC. A significant number of patients will experience recurrence and die from metastatic disease. Using platinum-based regimen during concurrent chemoradiotherapy (CCRT) has been the standard of care for LACC according to the National Comprehensive Cancer Network (NCCN) guidelines [3]. Moreover, with a lack of radiotherapy equipment and severe radiotherapy-related complications, there is an increasing risk of occurrence of second tumor [4]. Some regions still prefer to recommend surgery after neoadjuvant chemotherapy (NACT), especially in young patients. Paclitaxel drugs combined with platinum drug regimens are commonly used in NACT. However, severe allergic reactions have occurred in some people taking paclitaxel drugs, and NACT is ineffective in certain cases leading to disease progression [5]. Therefore, it is necessary to find more effective NACT regimens for LACC patients. Traditional Chinese medicines arsenic trioxide (As2O3) have been used for hundreds of years, and recently it is widely accepted as an alternative treatment for acute promyelocytic leukemia (APL) and liver cancer [6]. It was found that degradation of retinoic acid receptor alpha (PML-RARα) oncogene was the main mechanism of As2O3 in the treatment of APL. At present, the anti-tumor mechanisms of As2O3 have been found to include but are not limited to, induction of caspase-3, generation of reactive oxygen species (ROS), alteration of the cell cycle, reduction of stem cell markers, and inhibition of glioma-associated oncogene family zinc finger (GLI) transcription factors [7]. However, whether it can be used in LACC patients is currently unknown. On this basis, our department started a phase II clinical study to explore the effect of As2O3 plus carboplatin in the therapy of LACC and compare the efficacy and safety of carboplatin combined with As2O3 versus carboplatin combined with docetaxel during neoadjuvant treatment.

2 Methods

2.1 Study design and participants

It was a single-center, phase II, open-label randomized prospective clinical trial (Clinical trial registration number: ChiCTR1900023822), and 44 LACC patients from the First Affiliated Hospital of Guangzhou University of Chinese medicine were enrolled to explore the effects of carboplatin combined with As2O3 versus carboplatin combined with docetaxel during neoadjuvant treatment. A central randomization system is used for experimental group (carboplatin combined with As2O3) and control group (carboplatin combined with docetaxel), respectively.

2.2 Study population

Patients with LACC were eligible for the trial. The inclusion and exclusion criteria have been set by the investigators.

Inclusion criteria included: (1) all patients need to sign an informed consent form; (2) aged 20–70 years old, female; (3) pathologically and radiographically confirmed as treatment-naive, LACC patients with stage IB2–IIB (the 2009 International Federation of Gynecology and Obstetrics [FIGO]) staging; (4) Karnofsky performance status scale ≥70; and (5) the blood cell counts, serum creatinine, aspartate aminotransferase, alanine aminotransferase, and bilirubin were normal.

2.3 Exclusion criteria

Patients who met any of the following criteria were excluded: (1) history of recurrence or distant metastasis; (2) history of surgery, chemotherapy, radiotherapy, or immunotherapy; (3) history of malignancies or concurrent malignancies; (4) females in pregnancy or lactation; (5) history of allergy to arsenic; and (6) previously participated in other clinical trials in the past 3 months.

2.4 Study endpoints

Study endpoints included: (1) deterioration; (2) severe bone marrow suppression; (3) history of surgery, chemotherapy, radiotherapy, or immunotherapy; (4) alanine transaminase or aspartate aminotransferase above three folds or creatinine above two folds, the upper limit of normal; (5) abnormal cardiac function during treatment, such as frequent ventricular premature beats; (6) patient who cannot tolerate the treatment, and side effects such as skin and mucosal lesions, where severe drug extravasation occurred; (7) metastasis during the treatment; and (8). poor compliance and cannot be followed up.

2.5 Randomization and masking

We randomly assigned eligible patients to either study group according to the ratio of 1:1. Therapy assignment was unmasked in the two following manners: (1) the investigators obtained informed consent from eligible patients and (2) the details of treatment allocations were opened sealed opaquely.

2.6 Procedures

All patients who were diagnosed underwent cervical biopsy. Pelvic examination was also performed to determine the stage of FIGO. Furthermore, blood tests, MRI, and ultrasonography of the abdomen and pelvis were also performed before random assignment. Patients received either two cycles of As2O3 (8 mg/m2) plus carboplatin once every 3 weeks or two cycles of docetaxel (75 mg/m2) plus carboplatin once every 3 weeks. The amount of carboplatin was calculated according to the region of curves 5–6. Clinical responses were evaluated after the second chemotherapy cycle. Patients who had no response or disease progression in the NACT received CCRT. However, if patients responded to the treatment of two cycle of NACT, they accepted Piver-Rutledge class III radical abdominal hysterectomy and underwent laparoscopic para-aortic lymph node dissection if necessary.

2.7 Statistical analysis

Statistical analysis was performed through the Statistic Package for Social Science (SPSS) 20.0 software (IBM, Armonk, NY, USA). The sample size of this study was small, and the data with multi-class attributes were used. Fisher’s exact test provides an accurate, reliable, and easy to implement statistical analysis method for small sample categorical data, which is especially suitable for pilot studies, exploratory studies, and studies conducted when large samples are not available. We therefore used Fisher’s test to analyze the data we obtained. Student’s t-test was carried out for the comparison of continuous variables by mean ± standard deviation, while χ 2 test was used to compare categorical variables. P-value < 0.05 was considered to be statistically significant.

  1. Ethical approval: This study was approved by the Ethical Committee of The First Affiliated Hospital of Guangzhou University of Chinese Medicine (approval no. K-2019-023). This study was conducted in accordance with the Declaration of Helsinki and followed the ethical standards of China.

  2. Informed consent: Signed written informed consents were obtained from the patients and/or guardians.

3 Results

3.1 Patient characteristics

A total of 48 patients with stage IB2-IIB cervical cancer were enrolled in this study between January 2019 and May 2022 and were randomly assigned to either the experimental group (carboplatin combined with As2O3, n = 24) or the control group (carboplatin combined with docetaxel, n = 24). Patient characteristics are summarized in Table 1. The data cutoff date for this analysis was May 31, 2022. All enrolled patients have signed the informed consent, and all relevant investigations were performed according to the principles of the Declaration of Helsinki. Eighteen patients among the experimental group had completed two courses of chemotherapy and surgical treatments, and five patients had completed two courses of chemotherapy (three of them were lost to follow-up and two patients requested transfer to another hospital for further treatment), and one patient was lost to follow-up after completing one course of chemotherapy. Meanwhile, 19 patients of the control group had completed two courses of chemotherapy and surgical treatments, three patients had completed two courses of chemotherapy (one patient was automatically transferred to a specialist hospital for treatment and two patients were lost to follow-up), and two patients had completed one course of chemotherapy (two patients were lost to follow-up) (Table 2).

Table 1

Baseline characteristics of the patients included in this study

As2O3 plus carboplatin group (n = 24) Docetaxel plus carboplatin group (n = 24) P-value P-value*
Age (years) 55.33 ± 8.96 54.83 ± 11.82 0.870 0.870
BMI (kg/m2) 23.70 ± 3.82 23.07 ± 3.90 0.560 0.560
Previous pregnancies 3.71 ± 1.58 3.88 ± 1.92 0.744 0.744
Previous live births 2.96 ± 1.55 3.00 ± 1.82 0.932 0.932
Previous miscarriages 0.75 ± 1.11 0.86 ± 0.95 0.884 0.884
Hypertension 0.7 1.000
 Yes 6(25.00%) 5(20.83%)
 No 18(75.00%) 19(79.17%)
Diabetes 0.551 1.000
 Yes 2(8.33%) 1(4.17%)
 No 22(91.70%) 23(95.83%)
Cardiopathy 0.296 0.609
 Yes 3(12.50%) 1(4.17%)
 No 21(87.50%) 23(95.83%)
Delivery method 0.532 1.000
 Vaginal delivery 22(91.67%) 20(83.33%)
 Cesarean delivery 2(8.33%) 1(4.17%)
FIGO stage 0.845 —
 IB2 6(25.00%) 7(29.17%)
 IIA 12(50.00%) 10(41.66%)
 IIB 6(25.00%) 7(29.17%)
Histological subtypes 0.600 —
 Squamous cell carcinoma 22(91.67%) 23(95.83%)
 Adenocarcinoma 1(4.17%) 0(0.00%)
 Others** 1(4.17%) 1(4.17%)

Data are mean ± SD/n(%). *P-values were calculated with independent t-test, if it is a continuous variable and calculated with unadjusted χ 2 test, if it is a categorical variable; **including adenosquamous carcinoma and clear cell carcinoma.

Table 2

Treatment accomplishment in both the groups

As2O3 plus carboplatin group Docetaxel plus carboplatin group
Two cycles of NACT plus surgery 18(75.00%) 19(79.17%)
Two cycles of NACT 5(20.83%) 3(12.50%)
One cycle of NACT 1(4.17%) 2(8.33%)

Data are n(%).

3.2 Tumor response

Response Evaluation Criteria in Solid Tumors, version 1.1CIST 1.1) was used to evaluate the clinical efficacy. This standard is the most widely accepted and used imaging response evaluation standard in clinical trials of solid tumors. The effect is divided into complete response, partial response, stable disease, or progressive disease [8]. The clinical effects are shown in Table 3. Compared to the control group, the total effective rates of the experimental group were 72.22 and 68.42%, respectively. There was no statistically significant difference between the two groups, P > 0.05.

Table 3

Short-term clinical efficacy in both groups

Treatment N Complete response + partial response Stable disease Progressive disease Total effective rates (%) χ 2 P*
As2O3 plus carboplatin 18 13(72.22%) 5(27.79%) 0 72.22 0.800 1.000
Docetaxel plus carboplatin 19 13(68.42%) 6(31.58%) 0 68.42

Data are n(%). *P-values were calculated with Fisher’s exact test.

3.3 Serological response

Squamous cell carcinoma (SCC) is a protein over-expressed in the occurrence and development of cervical cancer, which is often used to evaluate the prognosis of cervical cancer [9]. The level of SCC was decreased significantly before and after chemotherapy in both the groups. Compared with before chemotherapy, there was a statistical difference in the decrease of SCC after chemotherapy, P < 0.05 (Tables 4 and 5). While comparing the decline of SCC before and after treatment in the two groups, there was no statistical difference between the two groups, P > 0.05 (Table 6).

Table 4

Comparison of serum SCC before chemotherapy and before surgery in As2O3 plus carboplatin group

SCC (ng/mL) N Before chemotherapy Before surgery t P
Normal 5 1.02 ± 0.40 1.08 ± 0.35 −0.548 0.806
Abnormal 13 18.62 ± 20.65 12.62 ± 15.84 0.831 0.414

Data are mean ± SD/n(%).

Table 5

Comparison of serum SCC before chemotherapy and before surgery in docetaxel plus carboplatin group

SCC (ng/mL) N Before chemotherapy Before surgery t P
Normal 8 0.91 ± 0.33 0.79 ± 0.43 0.655 0.655
Abnormal 11 13.37 ± 20.28 4.95 ± 9.47 2.295 0.045

Data are mean ± SD/n(%).

Table 6

Serum SCC in both the groups

SCC (ng/mL) As2O3 plus carboplatin group Docetaxel plus carboplatin group t P
Before chemotherapy 18.62 ± 20.65 13.37 ± 20.28 0.626 0.538
Before surgery 12.62 ± 15.84 4.95 ± 9.47 1.406 0.174
Difference value 6.00 ± 11.36 8.42 ± 12.17 −0.505 0.619

Data are mean ± SD/n(%).

3.4 Intraoperative bleeding and duration of operation

The intraoperative bleeding and duration of operation of the two groups were contrasted. The average intraoperative bleeding of the experimental group and the control group was 547.22 ± 475.74 mL vs 533.16 ± 486.65 mL, P > 0.05), and the average duration of operation was 224.67 ± 32.87 min vs 225.32 ± 64.11 min, P > 0.05, there were no statistically significant difference between the two groups (Table 7).

Table 7

Surgery related indicators in both the groups

As2O3 plus carboplatin group Docetaxel plus carboplatin group t P
N 18 19
Intraoperative bleeding (mL) 547.22 ± 475.74 533.16 ± 486.65 0.09 0.929
Length of surgery (min) 224.67 ± 32.87 225.32 ± 64.11 0.038 0.970

Data are mean ± SD/n(%).

3.5 Safety and toxicity

Hematological indicators before the first chemotherapy were used as baseline data in patients who have completed two chemotherapy sessions and surgery, and the hematological indicators before the second chemotherapy and surgery served as indicators of hematological changes under the action of chemotherapy drugs. While for the patients who have completed only two chemotherapy sessions, hematological indicators before the first chemotherapy were used as baseline data, and hematological indicator changes before and after the second chemotherapy were collected. For patients who have completed only one chemotherapy session, the hematological indicators before the first chemotherapy were used as baseline data, and the changes of hematological indicators after the first chemotherapy were collected. In summary, a total of 84 hematology evaluation results were collected for statistical analysis, as shown in Table 8. For the incidence of adverse reactions in the blood system and liver and kidney function, the comparison between the two groups of patients was also not statistically different (P > 0.05). The gastrointestinal adverse reactions that occurred during the two chemotherapy treatments in the two groups were also collected and there were no significant difference between the two groups (Table 9). Others adverse reactions that occurred during the two chemotherapy treatments in the two groups were also collected and there was no visible statistical difference between the two groups (Table 10).

Table 8

Hematological adverse events reported during treatment in both the groups

As2O3 plus carboplatin group Docetaxel plus carboplatin group P-value P-value*
N 47 45
Leucopenia 0.114
 0 33(70.21%) 28(62.22%)
 I 12(25.53%) 8(17.77%)
 II 2(4.26%) 7(15.55%)
 III 0(0.00%) 2(4.44%)
Neutropenia 0.360
 0 31(65.96%) 23(51.11%)
 I 10(21.28%) 12(26.67%)
 II 5(10.64%) 6(13.33%)
 III 1(2.13%) 4(8.88%)
Anemia 0.137
 0 29(61.70%) 34(75.56%)
 I 15(31.91%) 11(24.44%)
 II 3(6.38%) 0(0.00%)
Thrombocytopenia 0.325 1.000
 0 46(97.87%) 45(100.00%)
 I 1(2.13%) 0(0.00%)
Hepatotoxicity 0.577
 0 42(89.36%) 42(93.33%)
 I 4(8.51%) 3(6.66%)
 II 1(2.13%) 0(0.00%)
Nephrotoxicity 0.184 0.362
 0 43(91.49%) 44(97.77%)
 I 4(8.51%) 1(2.22%)

Data are n(%). *P-values were calculated with Fisher’s exact test.

Table 9

Gastrointestinal adverse events reported during treatment in both the groups

As2O3 plus carboplatin group Docetaxel plus carboplatin group P-value P-value*
N 47 45
Nausea 0.738
 0 26(55.32) 29(62.22%)
 I 3(6.38%) 4(8.88%)
 II 14(29.79%) 9(20.00%)
 III 4(8.51%) 4(8.88%)
Diarrhea 0.325 1.000
 0 46(97.87%) 45(100.00%)
 I 1(2.13%) 0(0.00%)
Constipate 0.450 0.575
 0 38(80.85%) 39(86.67%)
 I 9(19.15%) 6(13.33%)

Data are n(%). *P-values were calculated with Fisher’s exact test.

Table 10

Others adverse events reported during treatment in both the groups

As2O3 plus carboplatin group Docetaxel plus carboplatin group P-value P-value*
N 47 45
Allergic reaction 0.975 1.000
0 46(97.87%) 44(97.88%)
I 1(2.13%) 1(2.22%)
Ache 0.300
0 41(87.23%) 39(86.67%)
I 6(12.77%) 4(8.88%)
II 0(0.00%) 2(4.44%)
Mucositis 0.325 1.000
0 46(97.87%) 45(100.00%)
I 1(2.13%) 0(0.00%)
Neurotoxicity 0.162 0.495
0 45(95.74%) 45(100.00%)
I 2(4.26%) 0(0.00%)

Data are n(%). *P-values were calculated with Fisher’s exact test.

4 Discussion

Our innovative use of As2O3 combined with carboplatin in the treatment of LACC has produced similar efficacy and tolerable side effects as docetaxel combined with carboplatin, which provides a new insight for cervical cancer’s treatment. This study aims to evaluate the clinical effects of As2O3 combined with carboplatin in LACC and compared with paclitaxel combined with carboplatin drugs to explore another effective, safe, and economical drug for LACC. Our data showed that there was no significant difference in the efficacy and safety between the two groups. The total effective rates of the experimental group and the control group were 72.22 and 68.42%, respectively. The serum SCC was also not statistically significant between the two groups. In addition, the average blood loss during operation, the average operation time, and the incidence of adverse reactions were also not statistically different. These data indicated that As2O3 has been shown to successfully improve survival outcomes in patients with LACC. Although our data provided another option for the treatment of LACC, there are still some limitations in the research process. The number of patients included in this study is limited, and more samples are needed to further prove the effectiveness and universality of this therapy. Unfortunately, due to the dropout of patients in this study, we did not obtain enough information from this study. In addition, this study only collected the adverse reactions of chemotherapy in patients during hospitalization. Due to the large difference in hospitalization time between the two groups, the 18 patients in the experimental group had much longer hospital stay than those in the control group, so the safety evaluation may be biased. Therefore, we expect to further improve the study of long-term side effects of chemotherapy during follow-up. Our data show that the As2O3 plus carboplatin provides more options for the treatment of LACC.

As2O3 is one of the effective components of arsenic in traditional Chinese medicine. Ben cao gang mu (Compendium of Materia Medica) has recorded that “arsenic is a poisonous medicine.” This is because As2O3 has a narrow therapeutic window, and it is easy to produce toxic side effects. But with the right preparation method and appropriate dosage, As2O3 can be used to treat tumors as a traditional Chinese medicine. Since the 1970s, clinical studies in China showed that As2O3 is an effective treatment for APL patients in obtaining high clinical complete remission rates and small side effects such as bone marrow suppression. In 2001, it was approved by the US Food and Drug Administration for the treatment of APL [6]. Later studies found that As2O3 has been extended for the treatment of breast cancer [10], lung cancer [11,12], gastric cancer [13,14], liver cancer [15,16], bladder cancer [17], cervical cancer [18], and other solid tumors. As2O3 has also been demonstrated to induce significant clinical benefits of antitumor effects in a wide range of solid tumors including gallbladder cancer [19], pancreatic cancer [20], lung cancer [21], and liver cancer. Due to the lower cost and smaller side effects, As2O3 has attracted more and more attention in the gynecological tumor. Currently research studies have demonstrated the role of As2O3 in suppressing the proliferation of tumor cells and induce mitochondria apoptosis [22,23] or up-regulating intracellular ROS induced lipid peroxidation [24] of cervical cancer cells both in vitro and in vivo. The NCCN guideline insights show that the combination with platinum-based chemotherapy drugs serve as effective drugs for the treatment of cervical cancer [25]. The combination of carboplatin and docetaxel is an effective and well-tolerated treatment for patients with advanced cervical cancer. However, whether the combination of As2O3 and carboplatin has the same anti-tumor effect and less side effects compared to the combination of carboplatin and docetaxel needs further clinical study. Previous clinical trials have demonstrated that the synergism of As2O3 and platinum drugs inhibited the cell growth and induced cell apoptosis of tumor cells in a dose-dependent manner, such as oral cancer cells [26], hepatocarcinoma cells [27], colorectal cancer cells [28], and non-small cell lung cancer cells [29]. In vivo experiments also show that As2O3 combined with platinum drugs can inhibit the growth of transplanted tumors in mouse model [30]. Moreover, there is no increased toxic side effect in this combination [31]. Based on the experience of As2O3 combination both in vitro and in vivo of tumor model, we innovatively used As2O3 combined with carboplatin to treat LACC patients, and observed its efficacy and safety.

Conclusively, we found that As2O3 combined with carboplatin, as a chemotherapy regimen for LACC is not worse than docetaxel combined with carboplatin in terms of short-term efficacy and safety during the treatment of LACC. It provides a new chemotherapy regimen for the treatment of LACC patients, and also provides a new idea for the treatment of advanced and recurrent cervical cancer.

Abbreviations

APL

acute promyelocytic leukemia

CCRT

concurrent chemoradiotherapy

FIGO

Federation of Gynecology and Obstetrics

LACC

locally advanced cervical cancer

NACT

neoadjuvant chemotherapy

NCCN

National Comprehensive Cancer Network

Acknowledgements

We thank Prof. Luo Songping and Prof. Gao Jie for their kindly support in the design and statistical analysis of this study.

  1. Funding information: This work was supported by the Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine (Project No: 20194005) “Project name: Study on the mechanism of PI3/AKT/mTOR signaling pathway mediated by arsenic trioxide to regulate carboplatin resistance of Hela cells to cervical cancer.” Medical Science and Technology Research Fund of Guangdong Province (Project No. B2024039) “Project name: Study on the mechanism of NPM1-mediated P53-dependent iron death mediated by arsenic trioxide against cisplatin resistance in cervical cancer Hela cells.”

  2. Author contributions: S.L. and D.L. designed the study; Y.Z., H.L., and Z.H. collected the data; A.L. and J.Y. analyzed the data; S.L. and D.L. prepared the manuscript. All authors read and approved the final manuscript.

  3. Conflict of interest: The authors declare no conflict of interest.

  4. Statement: This manuscript has a pre-print: https://www.researchsquare.com/article/rs-2030928/v1.

  5. Data availability statement: All data generated or analyzed during this study are included in this article. The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.

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Received: 2024-09-23
Revised: 2024-11-07
Accepted: 2024-11-08
Published Online: 2024-12-12

© 2024 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Articles in the same Issue

  1. Research Articles
  2. EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway
  3. STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
  4. Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
  5. The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma
  6. METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
  7. Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
  8. Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty
  9. Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
  10. Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma
  11. Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue
  12. Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
  13. Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease
  14. METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients
  15. Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis
  16. Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay
  17. Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity
  18. Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound
  19. Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement
  20. miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization
  21. The analyses of human MCPH1 DNA repair machinery and genetic variations
  22. Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
  23. Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma
  24. Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
  25. The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
  26. Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis
  27. Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
  28. Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer
  29. Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke
  30. The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
  31. Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study
  32. Lactate dehydrogenase to albumin ratio is associated with in-hospital mortality in patients with acute heart failure: Data from the MIMIC-III database
  33. CD36-mediated podocyte lipotoxicity promotes foot process effacement
  34. Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
  35. FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
  36. Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
  37. Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
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  39. Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy
  40. Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction
  41. High SEC61A1 expression predicts poor outcome of acute myeloid leukemia
  42. Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
  43. Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway
  44. Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
  45. Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
  46. Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
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  142. The effect of COVID-19 lockdown on admission rates in Maternity Hospital
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  147. Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
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  180. Investigating hormesis, aging, and neurodegeneration: From bench to clinics
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https://doi.org/10.1515/med-2024-1106
Keywords for this article
locally advanced cervical cancer; arsenic trioxide; carboplatin; docetaxel; neoadjuvant chemotherapy
Creative Commons
BY 4.0

Articles in the same Issue

  1. Research Articles
  2. EDNRB inhibits the growth and migration of prostate cancer cells by activating the cGMP-PKG pathway
  3. STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
  4. Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population
  5. The pyroptosis-related signature predicts prognosis and influences the tumor immune microenvironment in dedifferentiated liposarcoma
  6. METTL3 attenuates ferroptosis sensitivity in lung cancer via modulating TFRC
  7. Identification and validation of molecular subtypes and prognostic signature for stage I and stage II gastric cancer based on neutrophil extracellular traps
  8. Novel lumbar plexus block versus femoral nerve block for analgesia and motor recovery after total knee arthroplasty
  9. Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction
  10. Study on the radiotherapy effect and serum neutral granulocyte lymphocyte ratio and inflammatory factor expression of nasopharyngeal carcinoma
  11. Transcriptome analysis of effects of Tecrl deficiency on cardiometabolic and calcium regulation in cardiac tissue
  12. Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
  13. Serum levels of HMW adiponectin and its receptors are associated with cytokine levels and clinical characteristics in chronic obstructive pulmonary disease
  14. METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients
  15. Understand how machine learning impact lung cancer research from 2010 to 2021: A bibliometric analysis
  16. Pressure ulcers in German hospitals: Analysis of reimbursement and length of stay
  17. Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity
  18. Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound
  19. Feasibility of 3-dimensional printed models in simulated training and teaching of transcatheter aortic valve replacement
  20. miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization
  21. The analyses of human MCPH1 DNA repair machinery and genetic variations
  22. Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy
  23. Comprehensive analysis based on the disulfidptosis-related genes identifies hub genes and immune infiltration for pancreatic adenocarcinoma
  24. Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis
  25. The clinical value of the hepatic venous pressure gradient in patients undergoing hepatic resection for hepatocellular carcinoma with or without liver cirrhosis
  26. Development and validation of a novel model to predict pulmonary embolism in cardiology suspected patients: A 10-year retrospective analysis
  27. Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
  28. Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer
  29. Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke
  30. The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
  31. Evaluating the impact of childhood BMI on the risk of coronavirus disease 2019: A Mendelian randomization study
  32. Lactate dehydrogenase to albumin ratio is associated with in-hospital mortality in patients with acute heart failure: Data from the MIMIC-III database
  33. CD36-mediated podocyte lipotoxicity promotes foot process effacement
  34. Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
  35. FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage
  36. Challenges in treating primary immune thrombocytopenia patients undergoing COVID-19 vaccination: A retrospective study
  37. Let-7 family regulates HaCaT cell proliferation and apoptosis via the ΔNp63/PI3K/AKT pathway
  38. Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition
  39. Postoperative cognitive dysfunction in elderly patients with colorectal cancer: A randomized controlled study comparing goal-directed and conventional fluid therapy
  40. Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction
  41. High SEC61A1 expression predicts poor outcome of acute myeloid leukemia
  42. Comparison of polymerase chain reaction and next-generation sequencing with conventional urine culture for the diagnosis of urinary tract infections: A meta-analysis
  43. Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway
  44. Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis
  45. Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1
  46. Autologous liver transplantation for unresectable hepatobiliary malignancies in enhanced recovery after surgery model
  47. Clinical analysis of incomplete rupture of the uterus secondary to previous cesarean section
  48. Abnormal sleep duration is associated with sarcopenia in older Chinese people: A large retrospective cross-sectional study
  49. No genetic causality between obesity and benign paroxysmal vertigo: A two-sample Mendelian randomization study
  50. Identification and validation of autophagy-related genes in SSc
  51. Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming
  52. Evaluation of quality of life in patients with schizophrenia: An inpatient social welfare institution-based cross-sectional study
  53. The possible role of oxidative stress marker glutathione in the assessment of cognitive impairment in multiple sclerosis
  54. Compilation of a self-management assessment scale for postoperative patients with aortic dissection
  55. Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
  56. Effect of anterior femoral cortical notch grade on postoperative function and complications during TKA surgery: A multicenter, retrospective study
  57. Clinical characteristics and assessment of risk factors in patients with influenza A-induced severe pneumonia after the prevalence of SARS-CoV-2
  58. Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
  59. High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression
  60. Factors influencing cardiovascular system-related post-COVID-19 sequelae: A single-center cohort study
  61. HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis
  62. Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
  63. Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
  64. ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
  65. Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
  66. The role of enhanced expression of Cx43 in patients with ulcerative colitis
  67. Choosing a COVID-19 vaccination site might be driven by anxiety and body vigilance
  68. Role of ICAM-1 in triple-negative breast cancer
  69. Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
  70. HLA-DRB5 promotes immune thrombocytopenia via activating CD8+ T cells
  71. Efficacy and factors of myofascial release therapy combined with electrical and magnetic stimulation in the treatment of chronic pelvic pain syndrome
  72. Efficacy of tacrolimus monotherapy in primary membranous nephropathy
  73. Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking
  74. FBXO45 levels regulated ferroptosis renal tubular epithelial cells in a model of diabetic nephropathy by PLK1
  75. Optimizing anesthesia strategies to NSCLC patients in VATS procedures: Insights from drug requirements and patient recovery patterns
  76. Alpha-lipoic acid upregulates the PPARγ/NRF2/GPX4 signal pathway to inhibit ferroptosis in the pathogenesis of unexplained recurrent pregnancy loss
  77. Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study
  78. CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway
  79. miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
  80. Immune response analysis of solid organ transplantation recipients inoculated with inactivated COVID-19 vaccine: A retrospective analysis
  81. The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
  82. Clinical efficacy of dexamethasone combined with isoniazid in the treatment of tuberculous meningitis and its effect on peripheral blood T cell subsets
  83. Comparison of short-segment and long-segment fixation in treatment of degenerative scoliosis and analysis of factors associated with adjacent spondylolisthesis
  84. Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
  85. Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL2
  86. Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
  87. Risk factors of postoperative airway obstruction complications in children with oral floor mass
  88. Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction
  89. Physical activity and mental health trends in Korean adolescents: Analyzing the impact of the COVID-19 pandemic from 2018 to 2022
  90. Evaluating anemia in HIV-infected patients using chest CT
  91. Ponticulus posticus and skeletal malocclusion: A pilot study in a Southern Italian pre-orthodontic court
  92. Causal association of circulating immune cells and lymphoma: A Mendelian randomization study
  93. Assessment of the renal function and fibrosis indexes of conventional western medicine with Chinese medicine for dredging collaterals on treating renal fibrosis: A systematic review and meta-analysis
  94. Comprehensive landscape of integrator complex subunits and their association with prognosis and tumor microenvironment in gastric cancer
  95. New target-HMGCR inhibitors for the treatment of primary sclerosing cholangitis: A drug Mendelian randomization study
  96. Population pharmacokinetics of meropenem in critically ill patients
  97. Comparison of the ability of newly inflammatory markers to predict complicated appendicitis
  98. Comparative morphology of the cruciate ligaments: A radiological study
  99. Immune landscape of hepatocellular carcinoma: The central role of TP53-inducible glycolysis and apoptosis regulator
  100. Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study
  101. SHP-1 mediates cigarette smoke extract-induced epithelial–mesenchymal transformation and inflammation in 16HBE cells
  102. Acute hyper-hypoxia accelerates the development of depression in mice via the IL-6/PGC1α/MFN2 signaling pathway
  103. The GJB3 correlates with the prognosis, immune cell infiltration, and therapeutic responses in lung adenocarcinoma
  104. Physical fitness and blood parameters outcomes of breast cancer survivor in a low-intensity circuit resistance exercise program
  105. Exploring anesthetic-induced gene expression changes and immune cell dynamics in atrial tissue post-coronary artery bypass graft surgery
  106. Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
  107. Analysis of the risk factors of the radiation-induced encephalopathy in nasopharyngeal carcinoma: A retrospective cohort study
  108. Reproductive outcomes in women with BRCA 1/2 germline mutations: A retrospective observational study and literature review
  109. Evaluation of upper airway ultrasonographic measurements in predicting difficult intubation: A cross-section of the Turkish population
  110. Prognostic and diagnostic value of circulating IGFBP2 in pancreatic cancer
  111. Postural stability after operative reconstruction of the AFTL in chronic ankle instability comparing three different surgical techniques
  112. Research trends related to emergence agitation in the post-anaesthesia care unit from 2001 to 2023: A bibliometric analysis
  113. Frequency and clinicopathological correlation of gastrointestinal polyps: A six-year single center experience
  114. ACSL4 mediates inflammatory bowel disease and contributes to LPS-induced intestinal epithelial cell dysfunction by activating ferroptosis and inflammation
  115. Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts
  116. Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
  117. The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae
  118. Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway
  119. Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study
  120. Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway
  121. Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population
  122. Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy
  123. Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study
  124. Decreased BIRC5-206 promotes epithelial–mesenchymal transition in nasopharyngeal carcinoma through sponging miR-145-5p
  125. Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
  126. Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis
  127. Tibial periosteum flap combined with autologous bone grafting in the treatment of Gustilo-IIIB/IIIC open tibial fractures
  128. The application of intravenous general anesthesia under nasopharyngeal airway assisted ventilation undergoing ureteroscopic holmium laser lithotripsy: A prospective, single-center, controlled trial
  129. Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
  130. Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
  131. Parental control attitudes over their pre-school children’s diet
  132. The role of auto-HSCT in extranodal natural killer/T cell lymphoma
  133. Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy
  134. Echinacoside inhibits PASMCs calcium overload to prevent hypoxic pulmonary artery remodeling by regulating TRPC1/4/6 and calmodulin
  135. ADAR1 plays a protective role in proximal tubular cells under high glucose conditions by attenuating the PI3K/AKT/mTOR signaling pathway
  136. The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study
  137. The unusual location of primary hydatid cyst: A case series study
  138. Intraoperative changes in electrophysiological monitoring can be used to predict clinical outcomes in patients with spinal cavernous malformation
  139. Obesity and risk of placenta accreta spectrum: A meta-analysis
  140. Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
  141. NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages
  142. The effect of COVID-19 lockdown on admission rates in Maternity Hospital
  143. Temporal muscle thickness is not a prognostic predictor in patients with high-grade glioma, an experience at two centers in China
  144. Luteolin alleviates cerebral ischemia/reperfusion injury by regulating cell pyroptosis
  145. Therapeutic role of respiratory exercise in patients with tuberculous pleurisy
  146. Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
  147. Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
  148. DMD mutations in pediatric patients with phenotypes of Duchenne/Becker muscular dystrophy
  149. Combination of C-reactive protein and fibrinogen-to-albumin ratio as a novel predictor of all-cause mortality in heart failure patients
  150. Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
  151. Ferroptosis-related prognostic model of mantle cell lymphoma
  152. Observation of choking reaction and other related indexes in elderly painless fiberoptic bronchoscopy with transnasal high-flow humidification oxygen therapy
  153. A bibliometric analysis of Prader-Willi syndrome from 2002 to 2022
  154. The causal effects of childhood sunburn occasions on melanoma: A univariable and multivariable Mendelian randomization study
  155. Oxidative stress regulates glycogen synthase kinase-3 in lymphocytes of diabetes mellitus patients complicated with cerebral infarction
  156. Role of COX6C and NDUFB3 in septic shock and stroke
  157. Trends in disease burden of type 2 diabetes, stroke, and hypertensive heart disease attributable to high BMI in China: 1990–2019
  158. Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
  159. Investigating the role of oviductal mucosa–endometrial co-culture in modulating factors relevant to embryo implantation
  160. Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study
  161. Elevated serum miR-142-5p correlates with ischemic lesions and both NSE and S100β in ischemic stroke patients
  162. Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
  163. Risk factors for progressive kyphosis after percutaneous kyphoplasty in osteoporotic vertebral compression fracture
  164. Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke
  165. The potential risk factors of postoperative cognitive dysfunction for endovascular therapy in acute ischemic stroke with general anesthesia
  166. Fluoxetine inhibited RANKL-induced osteoclastic differentiation in vitro
  167. Detection of serum FOXM1 and IGF2 in patients with ARDS and their correlation with disease and prognosis
  168. Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
  169. Differences in mortality risk by levels of physical activity among persons with disabilities in South Korea
  170. Review Articles
  171. Cutaneous signs of selected cardiovascular disorders: A narrative review
  172. XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis
  173. A narrative review on adverse drug reactions of COVID-19 treatments on the kidney
  174. Emerging role and function of SPDL1 in human health and diseases
  175. Adverse reactions of piperacillin: A literature review of case reports
  176. Molecular mechanism and intervention measures of microvascular complications in diabetes
  177. Regulation of mesenchymal stem cell differentiation by autophagy
  178. Molecular landscape of borderline ovarian tumours: A systematic review
  179. Advances in synthetic lethality modalities for glioblastoma multiforme
  180. Investigating hormesis, aging, and neurodegeneration: From bench to clinics
  181. Frankincense: A neuronutrient to approach Parkinson’s disease treatment
  182. Sox9: A potential regulator of cancer stem cells in osteosarcoma
  183. Early detection of cardiovascular risk markers through non-invasive ultrasound methodologies in periodontitis patients
  184. Advanced neuroimaging and criminal interrogation in lie detection
  185. Maternal factors for neural tube defects in offspring: An umbrella review
  186. The chemoprotective hormetic effects of rosmarinic acid
  187. CBD’s potential impact on Parkinson’s disease: An updated overview
  188. Progress in cytokine research for ARDS: A comprehensive review
  189. Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review
  190. NRXN1-related disorders, attempt to better define clinical assessment
  191. Lidocaine infusion for the treatment of complex regional pain syndrome: Case series and literature review
  192. Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis
  193. Iron in ventricular remodeling and aneurysms post-myocardial infarction
  194. Case Reports
  195. Sirolimus potentiated angioedema: A case report and review of the literature
  196. Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report
  197. Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman’s disease: A case report
  198. Complete heart block associated with hepatitis A infection in a female child with fatal outcome
  199. Elevation of D-dimer in eosinophilic gastrointestinal diseases in the absence of venous thrombosis: A case series and literature review
  200. Four years of natural progressive course: A rare case report of juvenile Xp11.2 translocations renal cell carcinoma with TFE3 gene fusion
  201. Advancing prenatal diagnosis: Echocardiographic detection of Scimitar syndrome in China – A case series
  202. Outcomes and complications of hemodialysis in patients with renal cancer following bilateral nephrectomy
  203. Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy
  204. Recurrent opportunistic infections in a HIV-negative patient with combined C6 and NFKB1 mutations: A case report, pedigree analysis, and literature review
  205. Letter to the Editor
  206. Letter to the Editor: Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
  207. Erratum
  208. Erratum to “Bladder-embedded ectopic intrauterine device with calculus”
  209. Retraction
  210. Retraction of “XRCC1 and hOGG1 polymorphisms and endometrial carcinoma: A meta-analysis”
  211. Corrigendum
  212. Corrigendum to “Investigating hormesis, aging, and neurodegeneration: From bench to clinics”
  213. Corrigendum to “Frankincense: A neuronutrient to approach Parkinson’s disease treatment”
  214. Special Issue The evolving saga of RNAs from bench to bedside - Part II
  215. Machine-learning-based prediction of a diagnostic model using autophagy-related genes based on RNA sequencing for patients with papillary thyroid carcinoma
  216. Unlocking the future of hepatocellular carcinoma treatment: A comprehensive analysis of disulfidptosis-related lncRNAs for prognosis and drug screening
  217. Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment
  218. Special Issue Advancements in oncology: bridging clinical and experimental research - Part I
  219. Ultrasound-guided transperineal vs transrectal prostate biopsy: A meta-analysis of diagnostic accuracy and complication rates
  220. Assessment of diagnostic value of unilateral systematic biopsy combined with targeted biopsy in detecting clinically significant prostate cancer
  221. SENP7 inhibits glioblastoma metastasis and invasion by dissociating SUMO2/3 binding to specific target proteins
  222. MARK1 suppress malignant progression of hepatocellular carcinoma and improves sorafenib resistance through negatively regulating POTEE
  223. Analysis of postoperative complications in bladder cancer patients
  224. Carboplatin combined with arsenic trioxide versus carboplatin combined with docetaxel treatment for LACC: A randomized, open-label, phase II clinical study
  225. Special Issue Exploring the biological mechanism of human diseases based on MultiOmics Technology - Part I
  226. Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma
  227. Identification of signatures associated with microsatellite instability and immune characteristics to predict the prognostic risk of colon cancer
  228. Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis
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