Startseite Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in Rats
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Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in Rats

  • Yu Shi , Feng Wang , A-Zhen Hu , Qing-Wen Wang , Jue-Lian Wu , Ming-Hua Li , Guang-Hui Cui , Li Liu , Si-Bin Huang , Yu Zhang , Han-Qing Liu EMAIL logo und Yun Chen EMAIL logo
Veröffentlicht/Copyright: 3. August 2018
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Open Chemistry
Aus der Zeitschrift Open Chemistry Band 16 Heft 1

Abstract

The aim of this study was to determine the effects of Jinniu Capsule on methamphetamine (METH)-induced conditioned place preference (CPP) in rats and identify the underlying mechanisms. An intraperitoneal injection of 3 mg/kg METH was used for CPP training in rats. The effects of Jinniu Capsule following a single dose on rat CPP and repeat dosing on METH withdrawal were evaluated. Western Blot analysis was used to measure protein expression of the PI3K-AKT-mTOR signaling pathway to determine the mechanisms of Jinniu Capsule. A single dose of Jinniu Capsule did not influence METH-induced CPP in rats. However, repeat dosing for 7 days significantly promoted METH withdrawal. Furthermore, METH withdrawal activated the PI3K-AKT-mTOR signaling pathway phosphorylation cascade, and Jinniu Capsule partly blocked this cascade. Jinniu Capsule demonstrated potential in promoting METH withdrawal in a rat CPP model, which may be related to its influence on the PI3K-AKT-mTOR signaling pathway.

Keywords: methamphetamine; conditioned place preference; Jinniu Capsule; withdrawal; mTOR signaling pathway

1 Introduction

Methamphetamine (METH) is a highly addictive psychostimulant drug that is easily synthesized from inexpensive and readily obtainable chemicals. METH can produce euphoria and stimulant effects, similar to those produced by other stimulants such as cocaine, and it is the second most frequently abused group of drugs worldwide. Based on the 2016 United Nations Office on Drugs and Crime World Drug Report, there are 33 million METH users worldwide. In China, there were 2.505 million drug addicts in 2016, of which 60.5% used synthetic drugs, with METH being the most widely used. METH abuse remains a global health challenge despite intense research interest in the development of pharmacological treatments. There are no pharmacological treatments specifically for METH addiction. The effective management of METH dependence remains elusive and the large majority of METH users relapse following treatment. Therefore, novel approaches to manage METH addiction are urgently needed [1,2,3,4].

Traditional Chinese medicine (TCM), which has been used to treat opiate dependence and withdrawal for over 200 years in China, offers potential alternatives to the pharmacotherapies currently used in allopathic medicine. TCM affects many body systems simultaneously, and has greater safety and fewer adverse effects, which may provide ideal treatment opportunities for drug addiction and withdrawal symptoms [5, 6]. Jinniu Capsule is composed of herbs and extracts of Hypericum Perforatum, Gastrodia Elata, Radix Paeoniae Alba, Calculus Bovis Artifactus, Salvia Miltiorrhiza, Pearl, Ginseng, Eleutherococcus Senticosus, and Spina Date Seed. Jinniu Capsules are safe for short- and long-term recommended dosages use in humans. The therapeutic effects of Jinniu Capsule on morphine withdrawal syndrome in rats and monkeys were observed in preclinical studies. Clinical trials demonstrated that Jinniu Capsules were safe and well-tolerated in healthy individuals with few side effects, and were effective and safe in the management of opiate withdrawal with no severe adverse events during treatment [7]. The purpose of this study was to observe the effects of Jinniu Capsule on METH-induced Conditioned Place Preference (CPP) in rats.

2 Materials and methods

2.1 Reagents

Jinniu Capsule, provided by Yiyuan Pharma Pte Ltd. (Gordon Industrial Building, Singapore), was dissolved in 1% carboxymethylcellulose sodium solution to a concentration of 100 mg/mL. METH (purity > 99%) was provided by Compulsory isolation detoxification of Shenzhen, 3 mg/mL solution was prepared with normal saline.

2.2 Animals

Sprague-Dawley rats, weighing 200–250 g, were purchased from Guangdong Medical Laboratory Animal Center (Foshan city, Guangdong, China). Animals were kept in plastic cages in a specific pathogen-free environment. A 12-h light/dark cycle, 19.2–25.1°C and 42%–59% relative humidity was maintained. Rats were acclimated for 5 days before treatment and allowed ad libitum access to food and water. The study was performed in accordance with the International Guidelines on the Care and Use of Animals for Scientific Purposes, and the protocol was approved by the Ethics Committee of Peking University Shenzhen Hospital.

2.3 CPP

The equipment for CPP training and testing consisted of five identical polyvinyl chloride (PVC) boxes. As shown in Figure 1 A, the box consisted of three chambers: two large side chambers with different floor textures (bar floor in left vs grid floor in right, respectively) separated by a smaller chamber with a smooth PVC floor. The three distinct chambers were separated by manual guillotine doors. Baseline preference (preconditioning test, Pre-C) was determined before CPP training, and the rats were initially placed in the middle chamber with the doors removed for 15 min. The times spent in the different chambers during the 15 min period were measured by a computer. Most rats showed a natural preference for the left chamber with the bar floor texture (Figure 1 B); therefore, the right chamber was set as the METH-paired chamber and the left chamber was the saline-paired chamber. Rats which showed strong unconditioned preference (> 540 s) in one of the three chambers were excluded. Conditioning was performed using an unbiased, balanced protocol. On the subsequent CPP training days, each rat was trained for 10 consecutive days with alternate injections of drug (METH 3 mg/kg, i.p.) and saline (1 mL/kg, i.p.). Rats were confined to the corresponding chambers for 45 min after drug or saline injection. The expression of METH-induced CPP (post-conditioning test, Post-C) was tested the day after the end of CPP training. The CPP score was defined as the time spent in the right chamber (METH-paired) minus that spent in the left chamber (saline-paired) [8,9,10].

Figure 1 METH-induced CPP in rats. (A) CPP training and testing equipment consisted of two large side chambers with different floor textures (bar floor in the left vs grid floor in the right, respectively) and a smaller middle chamber with a smooth PVC floor; (B) Historical laboratory data of rat’s natural preference, n = 630; (C) Protocol of CPP training and test; (D) Comparison of METH and saline, n = 10, the CPP score was defined as the time spent in the right chamber (METH-paired) minus that spent in the left chamber (saline-paired). Means ± SD, aaP< 0.01 vs left chamber; bP< 0.05 vs Pre-C test; cP < 0.05 vs saline group; ccP < 0.01 vs saline group. Pre-C: preconditioning test; Post-C: postconditioning test.
Figure 1

METH-induced CPP in rats. (A) CPP training and testing equipment consisted of two large side chambers with different floor textures (bar floor in the left vs grid floor in the right, respectively) and a smaller middle chamber with a smooth PVC floor; (B) Historical laboratory data of rat’s natural preference, n = 630; (C) Protocol of CPP training and test; (D) Comparison of METH and saline, n = 10, the CPP score was defined as the time spent in the right chamber (METH-paired) minus that spent in the left chamber (saline-paired). Means ± SD, aaP< 0.01 vs left chamber; bP< 0.05 vs Pre-C test; cP < 0.05 vs saline group; ccP < 0.01 vs saline group. Pre-C: preconditioning test; Post-C: postconditioning test.

2.4 Western Blot analysis

Rats were sacrificed 30 min after the end of the 15-min CPP test. Rat brains were removed, and the nucleus accumbens (NAc) was removed and placed in a 1.5-mL microtube containing ice-cold lysis buffer (Thermo Fisher Scientific, Waltham, MA, USA), 1 mM phenyl methane sulfonyl fluoride (Thermo Fisher Scientific, USA), 1 mM Na3VO4 (Sigma-Aldrich, St. Louis, MO USA), and 20 mM NaF (Sigma-Aldrich, St. Louis, MO USA) [11, 12]. The mixture was incubated for 30 min at 4°C and then centrifuged at 12,000 g for 15 min at 4°C. Protein samples were adjusted to the same concentration based on microspectrophotometer measurement, then 5 × loading buffer was added, and albuminous degeneration was performed for 10 min at 98°C. Aliquots of the samples (5.0-μL) were loaded into the wells of polyacrylamide gels and separated by electrophoresis at 80–120 V, respectively. The proteins were electrophoretically transferred onto Polyvinylidene Fluoride transfer membranes (Millipore, Bedford, MA, USA) for 1.5 h at 0.33 A. Primary antibodies were incubated with the membranes overnight at 4°C. After washing with Tris-buffered saline containing Tween (three times × 10 min), horseradish peroxidase-conjugated secondary antibody diluted to 1:2000 in blocking buffer was added and the membranes were incubated for 1 h at room temperature on a shaker. The ECL Chemiluminescence detection kit (Millipore, Bedford, MA, USA) was used to determine protein expression using a chemiluminescence detector (Tanon 5220S; Guangzhou Ewell Bio-technology Co., Ltd., Guangzhou, Guangdong, China). Target protein levels were normalized to β-actin and analyzed with Quantity One software (version 4.4.0; Bio-Rad, Hercules, CA, USA).

Anti-phospho-phosphatidylinositol 3-kinase (PI3K) R1 antibody (cat. no. PA5-17387), anti-PI3KR1 antibody (cat. no. PA5-38904), anti-protein kinase B (AKT) antibody (cat. no. AHO1112), anti-mammalian target of rapamycin (mTOR) antibody (cat. no. PA5-34663), anti-phospho-p70 ribosomal S6 kinase (p70s6k) antibody (cat. no. 701083), anti-p70s6k antibody (cat. no. MA5-15141), anti-phosphoribosomal protein s6 (rps6) antibody (cat. no. MA5-15140), anti-rps6 antibody (cat. no. MA5-15164), anti-phosphoeIF4E antibody (cat. no. PA5-17919) and anti-protein synthesis initiation factor 4E (eIF4E) antibody (cat. no. PA5-41751) were provided by Invitrogen Corporation (Carlsbad, CA, USA). Anti-phospho-AKT antibody (cat. no. #4060) and anti-phospho-mTOR antibody (cat. no. #5536) were purchased from Cell Signaling Technology (Danvers, MA, USA). All primary antibodies were diluted 1000 times with western blot antibody diluent.

2.5 Statistical analysis

All statistical analyses were performed using SPSS 17.0 software (SPSS, Inc., Chicago, IL, USA). Data are expressed as the means ± standard deviation (SD). One-way analysis of variance was used to compare inter-group differences. A probability (P) value of < 0.05 was considered statistically significant.

3 Results

3.1 METH-induced CPP

To assess CPP induced by METH, 20 male rats with no strong unconditioned preference (> 540 s) in each chamber were divided into 2 groups (n=10 per group). The Pre-C test was determined before CPP training. This was followed by 10 days CPP training as described above. The Post-C test was carried out the day after the end of CPP training. The time the rats spent in the left, middle and right chambers and the CPP scores in the METH and saline groups were compared (Figure 1 C).

As shown in Figure 1 D, training with 3 mg/kg METH induced obvious CPP in male rats, and the time rats spent in the 3 chambers was not significantly different between the saline and METH group in the Pre-C test. However, after 10 days training, rats in the METH group showed CPP, the time rats in the METH group spent in the left chamber decreased compared to that in the saline group (P < 0.05), and significantly decreased compared with the Pre-C test (P < 0.05). The changes in the right chamber (METH-paired) were the reverse of the left chamber, the time spent by rats in the METH group was longer than that in the saline group (P < 0.01) and in the Pre-C test (P < 0.05). The CPP scores in the METH group were significantly higher than those in the saline group.

3.2 Effects of single dose Jinniu Capsule on METH-induced CPP

To determine the effects of Jinniu Capsule on METH-induced CPP, 30 male rats with no strong unconditioned preference were divided into three groups (n = 10 per group). The Pre-C test and CPP training were performed as described above. The Post-C test was carried out the day after the end of CPP training. Thirty min before the test, Jinniu Capsule at a dose of 0.8 g/kg was administered intragastrically to rats in the METH + Jinniu Capsule (METH+JN) group, and the same volume of 1% Carboxymethylcellulose Sodium solution was administered to rats in the METH and control groups.

As shown in Figure 2, the time rats in the METH+JN group spent in the left and right chambers and the CPP scores were not significantly different to those in the METH group in the Pre-C and Post-C tests. These findings indicated that a single dose of Jinniu Capsule had no marked influence on METH-induced CPP.

Figure 2 Effects of single dose Jinniu Capsule on METH-induced CPP. Means ± SD, n = 10, aP < 0.05 vs control group; aaP < 0.01 vs control group. Pre-C: preconditioning test; Post-C: postconditioning test. The doses of METH and Jinniu Capsule were 3 mg/kg and 0.8 g/kg respectively. The Pre-C and Post-C tests were performed, and Jinniu Capsule was administered 30 min before Post-C test.
Figure 2

Effects of single dose Jinniu Capsule on METH-induced CPP. Means ± SD, n = 10, aP < 0.05 vs control group; aaP < 0.01 vs control group. Pre-C: preconditioning test; Post-C: postconditioning test. The doses of METH and Jinniu Capsule were 3 mg/kg and 0.8 g/kg respectively. The Pre-C and Post-C tests were performed, and Jinniu Capsule was administered 30 min before Post-C test.

3.3 Effects of Jinniu Capsule on METH withdrawal

To determine the effects of Jinniu Capsule on METH withdrawal, 30 male rats with no strong unconditioned preference were divided into three groups (n = 10 per group). The Pre-C test and CPP training were performed as described above. The day after the end of CPP training, Jinniu Capsule at a dose of 0.8 g/kg was administered intragastrically to rats every day in the METH + JN group, and the same volume of 1% carboxymethylcellulose sodium solution was administered to rats in the METH and control groups. The Post-C test and post treatment (Post-T) test were carried out on Day 1 and Day 7 after the end of CPP training, respectively.

As shown in Figure 3, METH-induced CPP did not change 7 days after CPP training in the METH group, as the time rats in the METH group spent in the left and right chambers and the CPP scores were not obviously different to those in the control group (P < 0.05, P < 0.01). Jinniu Capsule administered for 7 days significantly decreased the CPP scores compared with the METH group (P < 0.01). These findings indicated that long-term administration of Jinniu Capsule may promote METH withdrawal.

Figure 3 Effects of repeat doses of Jinniu Capsule on METH withdrawal in the CPP test. Means ± SD, n = 10, aP < 0.05 vs control group; aaP < 0.01 vs control group; bP < 0.05 vs METH group; bbP < 0.01 vs METH group. Pre-C: preconditioning test; Post-C: postconditioning test; Post-T: post treatment test. The doses of METH and Jinniu Capsule were 3 mg/kg and 0.8 g/kg respectively. The Pre-C, Post-C and Post-T tests were performed; Jinniu Capsule was administered every day for totally 7 days after the CPP training.
Figure 3

Effects of repeat doses of Jinniu Capsule on METH withdrawal in the CPP test. Means ± SD, n = 10, aP < 0.05 vs control group; aaP < 0.01 vs control group; bP < 0.05 vs METH group; bbP < 0.01 vs METH group. Pre-C: preconditioning test; Post-C: postconditioning test; Post-T: post treatment test. The doses of METH and Jinniu Capsule were 3 mg/kg and 0.8 g/kg respectively. The Pre-C, Post-C and Post-T tests were performed; Jinniu Capsule was administered every day for totally 7 days after the CPP training.

3.4 Mechanisms of Jinniu Capsule on METH withdrawal

The mTOR, a serine/threonine protein kinase that regulates cell growth and survival by controlling translation in response to nutrients and growth factors, has been demonstrated to be involved in neuronal adaptations that underlie drug addiction and learning and memory. mTOR signaling pathway in NAc were confirmed as the critical factor for cue-induced reinstatement of drug seeking in rats. To identify the mechanisms of Jinniu Capsule on METH withdrawal, all rats in Experiment 3 were sacrificed, the NAc was obtained from each rat and western blot analysis was performed as described above.

The phosphorylation of PI3K, AKT, mTOR, p70s6k, rps6, and eIF4E were examined.

As shown in Figure 4, the phosphorylation cascade of PI3K, AKT, mTOR, p70s6k, rps6, and eIF4E were activated by 7 days METH withdrawal in rat NAc in the CPP tests (P < 0.05, P < 0.05). Jinniu Capsule partly blocked phosphorylation of the above proteins (P < 0.05, P < 0.05).

Figure 4 Influence of METH and Jinniu Capsule on the PI3K-AKT-mTOR signaling pathway phosphorylation cascade. Means ± SD, n = 6, aP < 0.05 vs saline group; aaP < 0.01 vs saline group; bP < 0.05 vs METH group; bbP < 0.01 vs METH group. NAc of rats was obtained and the phosphorylation of PI3K, AKT, mTOR, p70s6k, rps6, and eIF4E were examined.
Figure 4

Influence of METH and Jinniu Capsule on the PI3K-AKT-mTOR signaling pathway phosphorylation cascade. Means ± SD, n = 6, aP < 0.05 vs saline group; aaP < 0.01 vs saline group; bP < 0.05 vs METH group; bbP < 0.01 vs METH group. NAc of rats was obtained and the phosphorylation of PI3K, AKT, mTOR, p70s6k, rps6, and eIF4E were examined.

4 Discussion

METH is abused worldwide and there is lack of effective treatments specifically for METH addiction. TCM such as Jinniu Capsule has demonstrated great potential in treating drug addiction. In previous studies, Jinniu Capsule showed therapeutic effects on morphine withdrawal syndrome both in animals and in clinical trials [7]. However, the effects of Jinniu Capsule on METH addiction are still unknown. In this study, we found that the administration of Jinniu Capsule for 7 days promoted METH withdrawal in rat CPP tests.

Relapse is the main difficulty in addiction withdrawal. Cue-induced drug-seeking in rodents progressively increases after withdrawal of cocaine, heroin, METH, and alcohol. The NAc is very important in the reward pathway, memory, and relapse. To identify the mechanisms of Jinniu Capsule, we observed changes in the signaling pathways in the NAc.

mTORC1 is a serine and threonine kinase that regulates cell growth, survival and proliferation by controlling translation in response to nutrients and growth factors, and has been demonstrated to be involved in the neuronal adaptations that underlie drug-related behaviors such as reward seeking and excessive drug intake [13]. Luo [14] found that mTOR signaling in the NAc shell, but not the core, is critical for the augmentation effect of trefoil factor 3 (TFF3) on behavioral response to cocaine. James [15] examined the role of mTORC1 in cocaine-related behaviors such as cocaine taking, withdrawal, and reinstatement of cocaine seeking, and found that withdrawal from cocaine self-administration increased the indices of mTORC1 activity in the NAc. Intra-cerebroventricular rapamycin reduced p-p70s6k, Ca2+/Calmodulin-dependent kinase II alpha (CAMKIIa) and AMPA receptor subunits (GluAs).

The phosphorylation of mTORC1 is regulated by the PI3K-AKT signaling pathway. Research has shown that psychoactive substances can induce cascade phosphorylation of PI3K-AKT. For example, following an intra-cerebroventricular injection of morphine, AKT was recruited to the synaptosomal membrane and activated by Thr308 and Ser473 phosphorylation [16]. Phentermine induces conditioned reward effects via activation of the PI3K-AKT signaling pathway in the NAc [17]. The PI3K inhibitors wortmannin and LY294002 decreased morphine-induced microglial migration, which is dependent on the PI3K-AKT pathway [18]. Activation of the μ-opioid receptor (OPRM1) by morphine induced time-dependent mTOR activation, and LY294002 blocked the late phase of mTOR activation [19].

In the present study, we found that after 7 days withdrawal in a METH-induced rat CPP model, the PI3K-AKT-mTORC1 phosphorylation cascade was activated in the NAc, and repeated administration of Jinniu Capsule for 7 days partly blocked the METH-induced PI3K-AKT-mTORC1 phosphorylation cascade. This may be the potential mechanisms by which Jinniu Capsule promotes METH withdrawal.

Furthermore, we observed phosphorylation downstream of mTORC1 such as phosphorylation of p70s6k, rps6 and eIF4E, which are also known to be regulatory factors in drug seeking and relapse. Similar to PI3K-AKT-mTORC1, p70s6k, rps6, and eIF4E in rat NAc were also phosphorylated after 7 days METH withdrawal in the CPP test; Jinniu Capsule also inhibited the phosphorylation of these kinases. Wang [20] found that the mTOR signaling pathway in the NAc core, but not the shell, was critical for cue-induced reinstatement of cocaine seeking in rats, and exposure to a cocaine-related cue increased p70s6k and rps6. Polakiewicz [21] found that μ-opioid agonists stimulated three different effectors of the PI3K-dependent signaling cascade; a specific agonist stimulated the activity of AKT, and upon μ-opioid receptor stimulation, p70s6k was activated and phosphorylated at Thr 389 and at Thr 421/Ser 424. The specific agonist stimulated the activity of AKT-stimulated phosphorylation of 4E-binding protein 1 and impaired its ability to bind the translation initiation factor eIF4E.

5 Conclusion

Jinniu Capsule demonstrated potential in promoting METH withdrawal in a rat CPP model, which may be related to its influence on the PI3K-AKT-mTOR signaling pathway.

Acknowledgements

We thank Health and Family Planning Commission of Shenzhen (201605018), Shenzhen Science and Technology Planning Project (JCYJ20160427185055877, ZDSYS201504301045406), Shenzhen “Sanming” project (SZSM201512026), Guangdong Bureau of Traditional Chinese Medicine Project (20171228) and Health and Family Planning Commission of Guangdong (B2018090) for financial support, and Compulsory isolation detoxification of Shenzhen for kindly providing the METH.

  1. Disclosure Statement: The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Received: 2018-04-04
Accepted: 2018-05-16
Published Online: 2018-08-03

© 2018 Yu Shi et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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  16. Experimental study on the regulation of the cholinergic pathway in renal macrophages by microRNA-132 to alleviate inflammatory response
  17. Synthesis, characterization, in-vitro antimicrobial properties, molecular docking and DFT studies of 3-{(E)-[(4,6-dimethylpyrimidin-2-yl)imino]methyl} naphthalen-2-ol and Heteroleptic Mn(II), Co(II), Ni(II) and Zn(II) complexes
  18. M-Polynomials and Topological Indices of Dominating David Derived Networks
  19. Human Health Risk Assessment of Trace Metals in Surface Water Due to Leachate from the Municipal Dumpsite by Pollution Index: A Case Study from Ndawuse River, Abuja, Nigeria
  20. Analysis of Bowel Diseases from Blood Serum by Autofluorescence and Atomic Force Microscopy Techniques
  21. Hydrographic parameters and distribution of dissolved Cu, Ni, Zn and nutrients near Jeddah desalination plant
  22. Relationships between diatoms and environmental variables in industrial water biotopes of Trzuskawica S.A. (Poland)
  23. Optimum Conversion of Major Ginsenoside Rb1 to Minor Ginsenoside Rg3(S) by Pulsed Electric Field-Assisted Acid Hydrolysis Treatment
  24. Antioxidant, Anti-microbial Properties and Chemical Composition of Cumin Essential Oils Extracted by Three Methods
  25. Regulatory mechanism of ulinastatin on autophagy of macrophages and renal tubular epithelial cells
  26. Investigation of the sustained-release mechanism of hydroxypropyl methyl cellulose skeleton type Acipimox tablets
  27. Bio-accumulation of Polycyclic Aromatic Hydrocarbons in the Grey Mangrove (Avicennia marina) along Arabian Gulf, Saudi Coast
  28. Dynamic Change of Secondary Metabolites and spectrum-effect relationship of Malus halliana Koehne flowers during blooming
  29. Lipids constituents from Gardenia aqualla Stapf & Hutch
  30. Effect of using microwaves for catalysts preparation on the catalytic acetalization of glycerol with furfural to obtain fuel additives
  31. Effect of Humic Acid on the Degradation of Methylene Blue by Peroxymonosulfate
  32. Serum containing drugs of Gua Lou Xie Bai decoction (GLXB-D) can inhibit TGF-β1-Induced Epithelial to Mesenchymal Transition (EMT) in A549 Cells
  33. Antiulcer Activity of Different Extracts of Anvillea garcinii and Isolation of Two New Secondary Metabolites
  34. Analysis of Metabolites in Cabernet Sauvignon and Shiraz Dry Red Wines from Shanxi by 1H NMR Spectroscopy Combined with Pattern Recognition Analysis
  35. Can water temperature impact litter decomposition under pollution of copper and zinc mixture
  36. Released from ZrO2/SiO2 coating resveratrol inhibits senescence and oxidative stress of human adipose-derived stem cells (ASC)
  37. Validated thin-layer chromatographic method for alternative and simultaneous determination of two anti-gout agents in their fixed dose combinations
  38. Fast removal of pollutants from vehicle emissions during cold-start stage
  39. Review Article
  40. Catalytic activities of heterogeneous catalysts obtained by copolymerization of metal-containing 2-(acetoacetoxy)ethyl methacrylate
  41. Antibiotic Residue in the Aquatic Environment: Status in Africa
  42. Regular Articles
  43. Mercury fractionation in gypsum using temperature desorption and mass spectrometric detection
  44. Phytosynthetic Ag doped ZnO nanoparticles: Semiconducting green remediators
  45. Epithelial–Mesenchymal Transition Induced by SMAD4 Activation in Invasive Growth Hormone-Secreting Adenomas
  46. Physicochemical properties of stabilized sewage sludge admixtures by modified steel slag
  47. In Vitro Cytotoxic and Antiproliferative Activity of Cydonia oblonga flower petals, leaf and fruit pellet ethanolic extracts. Docking simulation of the active flavonoids on anti-apoptotic protein Bcl-2
  48. Synthesis and Characterization of Pd exchanged MMT Clay for Mizoroki-Heck Reaction
  49. A new selective, and sensitive method for the determination of lixivaptan, a vasopressin 2 (V2)-receptor antagonist, in mouse plasma and its application in a pharmacokinetic study
  50. Anti-EGFL7 antibodies inhibit rat prolactinoma MMQ cells proliferation and PRL secretion
  51. Density functional theory calculations, vibration spectral analysis and molecular docking of the antimicrobial agent 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl] sulfanyl}pyrimidin-4(3H)-one
  52. Effect of Nano Zeolite on the Transformation of Cadmium Speciation and Its Uptake by Tobacco in Cadmium-contaminated Soil
  53. Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in Rats
  54. Calculating the Degree-based Topological Indices of Dendrimers
  55. Efficient optimization and mineralization of UV absorbers: A comparative investigation with Fenton and UV/H2O2
  56. Metabolites of Tryptophane and Phenylalanine as Markers of Small Bowel Ischemia-Reperfusion Injury
  57. Adsorption and determination of polycyclic aromatic hydrocarbons in water through the aggregation of graphene oxide
  58. The role of NR2C2 in the prolactinomas
  59. Chromium removal from industrial wastewater using Phyllostachys pubescens biomass loaded Cu-S nanospheres
  60. Hydrotalcite Anchored Ruthenium Catalyst for CO2 Hydrogenation Reaction
  61. Preparation of Calcium Fluoride using Phosphogypsum by Orthogonal Experiment
  62. The mechanism of antibacterial activity of corylifolinin against three clinical bacteria from Psoralen corylifolia L
  63. 2-formyl-3,6-bis(hydroxymethyl)phenyl benzoate in Electrochemical Dry Cell
  64. Electro-photocatalytic degradation of amoxicillin using calcium titanate
  65. Effect of Malus halliana Koehne Polysaccharides on Functional Constipation
  66. Structural Properties and Nonlinear Optical Responses of Halogenated Compounds: A DFT Investigation on Molecular Modelling
  67. DMFDMA catalyzed synthesis of 2-((Dimethylamino)methylene)-3,4-dihydro-9-arylacridin-1(2H)-ones and their derivatives: in-vitro antifungal, antibacterial and antioxidant evaluations
  68. Production of Methanol as a Fuel Energy from CO2 Present in Polluted Seawater - A Photocatalytic Outlook
  69. Study of different extraction methods on finger print and fatty acid of raw beef fat using fourier transform infrared and gas chromatography-mass spectrometry
  70. Determination of trace fluoroquinolones in water solutions and in medicinal preparations by conventional and synchronous fluorescence spectrometry
  71. Extraction and determination of flavonoids in Carthamus tinctorius
  72. Therapeutic Application of Zinc and Vanadium Complexes against Diabetes Mellitus a Coronary Disease: A review
  73. Study of calcined eggshell as potential catalyst for biodiesel formation using used cooking oil
  74. Manganese oxalates - structure-based Insights
  75. Topological Indices of H-Naphtalenic Nanosheet
  76. Long-Term Dissolution of Glass Fibers in Water Described by Dissolving Cylinder Zero-Order Kinetic Model: Mass Loss and Radius Reduction
  77. Topological study of the para-line graphs of certain pentacene via topological indices
  78. A brief insight into the prediction of water vapor transmissibility in highly impermeable hybrid nanocomposites based on bromobutyl/epichlorohydrin rubber blends
  79. Comparative sulfite assay by voltammetry using Pt electrodes, photometry and titrimetry: Application to cider, vinegar and sugar analysis
  80. MicroRNA delivery mediated by PEGylated polyethylenimine for prostate cancer therapy
  81. Reversible Fluorescent Turn-on Sensors for Fe3+ based on a Receptor Composed of Tri-oxygen Atoms of Amide Groups in Water
  82. Sonocatalytic degradation of methyl orange in aqueous solution using Fe-doped TiO2 nanoparticles under mechanical agitation
  83. Hydrotalcite Anchored Ruthenium Catalyst for CO2 Hydrogenation Reaction
  84. Production and Analysis of Recycled Ammonium Perrhenate from CMSX-4 superalloys
  85. Topical Issue on Agriculture
  86. New phosphorus biofertilizers from renewable raw materials in the aspect of cadmium and lead contents in soil and plants
  87. Survey of content of cadmium, calcium, chromium, copper, iron, lead, magnesium, manganese, mercury, sodium and zinc in chamomile and green tea leaves by electrothermal or flame atomizer atomic absorption spectrometry
  88. Biogas digestate – benefits and risks for soil fertility and crop quality – an evaluation of grain maize response
  89. A numerical analysis of heat transfer in a cross-current heat exchanger with controlled and newly designed air flows
  90. Freshwater green macroalgae as a biosorbent of Cr(III) ions
  91. The main influencing factors of soil mechanical characteristics of the gravity erosion environment in the dry-hot valley of Jinsha river
  92. Free amino acids in Viola tricolor in relation to different habitat conditions
  93. The influence of filler amount on selected properties of new experimental resin dental composite
  94. Effect of poultry wastewater irrigation on nitrogen, phosphorus and carbon contents in farmland soil
  95. Response of spring wheat to NPK and S fertilization. The content and uptake of macronutrients and the value of ionic ratios
  96. The Effect of Macroalgal Extracts and Near Infrared Radiation on Germination of Soybean Seedlings: Preliminary Research Results
  97. Content of Zn, Cd and Pb in purple moor-grass in soils heavily contaminated with heavy metals around a zinc and lead ore tailing landfill
  98. Topical Issue on Research for Natural Bioactive Products
  99. Synthesis of (±)-3,4-dimethoxybenzyl-4-methyloctanoate as a novel internal standard for capsinoid determination by HPLC-ESI-MS/MS(QTOF)
  100. Repellent activity of monoterpenoid esters with neurotransmitter amino acids against yellow fever mosquito, Aedes aegypti
  101. Effect of Flammulina velutipes (golden needle mushroom, eno-kitake) polysaccharides on constipation
  102. Bioassay-directed fractionation of a blood coagulation factor Xa inhibitor, betulinic acid from Lycopus lucidus
  103. Antifungal and repellent activities of the essential oils from three aromatic herbs from western Himalaya
  104. Chemical composition and microbiological evaluation of essential oil from Hyssopus officinalis L. with white and pink flowers
  105. Bioassay-guided isolation and identification of Aedes aegypti larvicidal and biting deterrent compounds from Veratrum lobelianum
  106. α-Terpineol, a natural monoterpene: A review of its biological properties
  107. Utility of essential oils for development of host-based lures for Xyleborus glabratus (Coleoptera: Curculionidae: Scolytinae), vector of laurel wilt
  108. Phenolic composition and antioxidant potential of different organs of Kazakh Crataegus almaatensis Pojark: A comparison with the European Crataegus oxyacantha L. flowers
  109. Isolation of eudesmane type sesquiterpene ketone from Prangos heyniae H.Duman & M.F.Watson essential oil and mosquitocidal activity of the essential oils
  110. Comparative analysis of the polyphenols profiles and the antioxidant and cytotoxicity properties of various blue honeysuckle varieties
  111. Special Issue on ICCESEN 2017
  112. Modelling world energy security data from multinomial distribution by generalized linear model under different cumulative link functions
  113. Pine Cone and Boron Compounds Effect as Reinforcement on Mechanical and Flammability Properties of Polyester Composites
  114. Artificial Neural Network Modelling for Prediction of SNR Effected by Probe Properties on Ultrasonic Inspection of Austenitic Stainless Steel Weldments
  115. Calculation and 3D analyses of ERR in the band crack front contained in a rectangular plate made of multilayered material
  116. Improvement of fuel properties of biodiesel with bioadditive ethyl levulinate
  117. Properties of AlSi9Cu3 metal matrix micro and nano composites produced via stir casting
  118. Investigation of Antibacterial Properties of Ag Doped TiO2 Nanofibers Prepared by Electrospinning Process
  119. Modeling of Total Phenolic contents in Various Tea samples by Experimental Design Methods
  120. Nickel doping effect on the structural and optical properties of indium sulfide thin films by SILAR
  121. The effect mechanism of Ginnalin A as a homeopathic agent on various cancer cell lines
  122. Excitation functions of proton induced reactions of some radioisotopes used in medicine
  123. Oxide ionic conductivity and microstructures of Pr and Sm co-doped CeO2-based systems
  124. Rapid Synthesis of Metallic Reinforced in Situ Intermetallic Composites in Ti-Al-Nb System via Resistive Sintering
  125. Oxidation Behavior of NiCr/YSZ Thermal Barrier Coatings (TBCs)
  126. Clustering Analysis of Normal Strength Concretes Produced with Different Aggregate Types
  127. Magnetic Nano-Sized Solid Acid Catalyst Bearing Sulfonic Acid Groups for Biodiesel Synthesis
  128. The biological activities of Arabis alpina L. subsp. brevifolia (DC.) Cullen against food pathogens
  129. Humidity properties of Schiff base polymers
  130. Free Vibration Analysis of Fiber Metal Laminated Straight Beam
  131. Comparative study of in vitro antioxidant, acetylcholinesterase and butyrylcholinesterase activity of alfalfa (Medicago sativa L.) collected during different growth stages
  132. Isothermal Oxidation Behavior of Gadolinium Zirconate (Gd2Zr2O7) Thermal Barrier Coatings (TBCs) produced by Electron Beam Physical Vapor Deposition (EB-PVD) technique
  133. Optimization of Adsorption Parameters for Ultra-Fine Calcite Using a Box-Behnken Experimental Design
  134. The Microstructural Investigation of Vermiculite-Infiltrated Electron Beam Physical Vapor Deposition Thermal Barrier Coatings
  135. Modelling Porosity Permeability of Ceramic Tiles using Fuzzy Taguchi Method
  136. Experimental and theoretical study of a novel naphthoquinone Schiff base
  137. Physicochemical properties of heat treated sille stone for ceramic industry
  138. Sand Dune Characterization for Preparing Metallurgical Grade Silicon
  139. Catalytic Applications of Large Pore Sulfonic Acid-Functionalized SBA-15 Mesoporous Silica for Esterification
  140. One-photon Absorption Characterizations, Dipole Polarizabilities and Second Hyperpolarizabilities of Chlorophyll a and Crocin
  141. The Optical and Crystallite Characterization of Bilayer TiO2 Films Coated on Different ITO layers
  142. Topical Issue on Bond Activation
  143. Metal-mediated reactions towards the synthesis of a novel deaminolysed bisurea, dicarbamolyamine
  144. The structure of ortho-(trifluoromethyl)phenol in comparison to its homologues – A combined experimental and theoretical study
  145. Heterogeneous catalysis with encapsulated haem and other synthetic porphyrins: Harnessing the power of porphyrins for oxidation reactions
  146. Recent Advances on Mechanistic Studies on C–H Activation Catalyzed by Base Metals
  147. Reactions of the organoplatinum complex [Pt(cod) (neoSi)Cl] (neoSi = trimethylsilylmethyl) with the non-coordinating anions SbF6– and BPh4–
  148. Erratum
  149. Investigation on Two Compounds of O, O’-dithiophosphate Derivatives as Corrosion Inhibitors for Q235 Steel in Hydrochloric Acid Solution
https://doi.org/10.1515/chem-2018-0074
Schlagwörter für diesen Artikel
methamphetamine; conditioned place preference; Jinniu Capsule; withdrawal; mTOR signaling pathway
Creative Commons
BY-NC-ND 4.0

Artikel in diesem Heft

  1. Regular Articles
  2. The effect of CuO modification for a TiO2 nanotube confined CeO2 catalyst on the catalytic combustion of butane
  3. The preparation and antibacterial activity of cellulose/ZnO composite: a review
  4. Linde Type A and nano magnetite/NaA zeolites: cytotoxicity and doxorubicin loading efficiency
  5. Performance and thermal decomposition analysis of foaming agent NPL-10 for use in heavy oil recovery by steam injection
  6. Spectroscopic (FT-IR, FT-Raman, UV, 1H and 13C NMR) insights, electronic profiling and DFT computations on ({(E)-[3-(1H-imidazol-1-yl)-1-phenylpropylidene] amino}oxy)(4-nitrophenyl)methanone, an imidazole-bearing anti-Candida agent
  7. A Simplistic Preliminary Assessment of Ginstling-Brounstein Model for Solid Spherical Particles in the Context of a Diffusion-Controlled Synthesis
  8. M-Polynomials And Topological Indices Of Zigzag And Rhombic Benzenoid Systems
  9. Photochemical Transformation of some 3-benzyloxy-2-(benzo[b]thiophen-2-yl)-4Hchromen-4-ones: A Remote Substituent Effect
  10. Dynamic Changes of Secondary Metabolites and Antioxidant Activity of Ligustrum lucidum During Fruit Growth
  11. Studies on the flammability of polypropylene/ammonium polyphosphate and montmorillonite by using the cone calorimeter test
  12. DSC, FT-IR, NIR, NIR-PCA and NIR-ANOVA for determination of chemical stability of diuretic drugs: impact of excipients
  13. Antioxidant and Hepatoprotective Effects of Methanolic Extracts of Zilla spinosa and Hammada elegans Against Carbon Tetrachlorideinduced Hepatotoxicity in Rats
  14. Prunus cerasifera Ehrh. fabricated ZnO nano falcates and its photocatalytic and dose dependent in vitro bio-activity
  15. Organic biocides hosted in layered double hydroxides: enhancing antimicrobial activity
  16. Experimental study on the regulation of the cholinergic pathway in renal macrophages by microRNA-132 to alleviate inflammatory response
  17. Synthesis, characterization, in-vitro antimicrobial properties, molecular docking and DFT studies of 3-{(E)-[(4,6-dimethylpyrimidin-2-yl)imino]methyl} naphthalen-2-ol and Heteroleptic Mn(II), Co(II), Ni(II) and Zn(II) complexes
  18. M-Polynomials and Topological Indices of Dominating David Derived Networks
  19. Human Health Risk Assessment of Trace Metals in Surface Water Due to Leachate from the Municipal Dumpsite by Pollution Index: A Case Study from Ndawuse River, Abuja, Nigeria
  20. Analysis of Bowel Diseases from Blood Serum by Autofluorescence and Atomic Force Microscopy Techniques
  21. Hydrographic parameters and distribution of dissolved Cu, Ni, Zn and nutrients near Jeddah desalination plant
  22. Relationships between diatoms and environmental variables in industrial water biotopes of Trzuskawica S.A. (Poland)
  23. Optimum Conversion of Major Ginsenoside Rb1 to Minor Ginsenoside Rg3(S) by Pulsed Electric Field-Assisted Acid Hydrolysis Treatment
  24. Antioxidant, Anti-microbial Properties and Chemical Composition of Cumin Essential Oils Extracted by Three Methods
  25. Regulatory mechanism of ulinastatin on autophagy of macrophages and renal tubular epithelial cells
  26. Investigation of the sustained-release mechanism of hydroxypropyl methyl cellulose skeleton type Acipimox tablets
  27. Bio-accumulation of Polycyclic Aromatic Hydrocarbons in the Grey Mangrove (Avicennia marina) along Arabian Gulf, Saudi Coast
  28. Dynamic Change of Secondary Metabolites and spectrum-effect relationship of Malus halliana Koehne flowers during blooming
  29. Lipids constituents from Gardenia aqualla Stapf & Hutch
  30. Effect of using microwaves for catalysts preparation on the catalytic acetalization of glycerol with furfural to obtain fuel additives
  31. Effect of Humic Acid on the Degradation of Methylene Blue by Peroxymonosulfate
  32. Serum containing drugs of Gua Lou Xie Bai decoction (GLXB-D) can inhibit TGF-β1-Induced Epithelial to Mesenchymal Transition (EMT) in A549 Cells
  33. Antiulcer Activity of Different Extracts of Anvillea garcinii and Isolation of Two New Secondary Metabolites
  34. Analysis of Metabolites in Cabernet Sauvignon and Shiraz Dry Red Wines from Shanxi by 1H NMR Spectroscopy Combined with Pattern Recognition Analysis
  35. Can water temperature impact litter decomposition under pollution of copper and zinc mixture
  36. Released from ZrO2/SiO2 coating resveratrol inhibits senescence and oxidative stress of human adipose-derived stem cells (ASC)
  37. Validated thin-layer chromatographic method for alternative and simultaneous determination of two anti-gout agents in their fixed dose combinations
  38. Fast removal of pollutants from vehicle emissions during cold-start stage
  39. Review Article
  40. Catalytic activities of heterogeneous catalysts obtained by copolymerization of metal-containing 2-(acetoacetoxy)ethyl methacrylate
  41. Antibiotic Residue in the Aquatic Environment: Status in Africa
  42. Regular Articles
  43. Mercury fractionation in gypsum using temperature desorption and mass spectrometric detection
  44. Phytosynthetic Ag doped ZnO nanoparticles: Semiconducting green remediators
  45. Epithelial–Mesenchymal Transition Induced by SMAD4 Activation in Invasive Growth Hormone-Secreting Adenomas
  46. Physicochemical properties of stabilized sewage sludge admixtures by modified steel slag
  47. In Vitro Cytotoxic and Antiproliferative Activity of Cydonia oblonga flower petals, leaf and fruit pellet ethanolic extracts. Docking simulation of the active flavonoids on anti-apoptotic protein Bcl-2
  48. Synthesis and Characterization of Pd exchanged MMT Clay for Mizoroki-Heck Reaction
  49. A new selective, and sensitive method for the determination of lixivaptan, a vasopressin 2 (V2)-receptor antagonist, in mouse plasma and its application in a pharmacokinetic study
  50. Anti-EGFL7 antibodies inhibit rat prolactinoma MMQ cells proliferation and PRL secretion
  51. Density functional theory calculations, vibration spectral analysis and molecular docking of the antimicrobial agent 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl] sulfanyl}pyrimidin-4(3H)-one
  52. Effect of Nano Zeolite on the Transformation of Cadmium Speciation and Its Uptake by Tobacco in Cadmium-contaminated Soil
  53. Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in Rats
  54. Calculating the Degree-based Topological Indices of Dendrimers
  55. Efficient optimization and mineralization of UV absorbers: A comparative investigation with Fenton and UV/H2O2
  56. Metabolites of Tryptophane and Phenylalanine as Markers of Small Bowel Ischemia-Reperfusion Injury
  57. Adsorption and determination of polycyclic aromatic hydrocarbons in water through the aggregation of graphene oxide
  58. The role of NR2C2 in the prolactinomas
  59. Chromium removal from industrial wastewater using Phyllostachys pubescens biomass loaded Cu-S nanospheres
  60. Hydrotalcite Anchored Ruthenium Catalyst for CO2 Hydrogenation Reaction
  61. Preparation of Calcium Fluoride using Phosphogypsum by Orthogonal Experiment
  62. The mechanism of antibacterial activity of corylifolinin against three clinical bacteria from Psoralen corylifolia L
  63. 2-formyl-3,6-bis(hydroxymethyl)phenyl benzoate in Electrochemical Dry Cell
  64. Electro-photocatalytic degradation of amoxicillin using calcium titanate
  65. Effect of Malus halliana Koehne Polysaccharides on Functional Constipation
  66. Structural Properties and Nonlinear Optical Responses of Halogenated Compounds: A DFT Investigation on Molecular Modelling
  67. DMFDMA catalyzed synthesis of 2-((Dimethylamino)methylene)-3,4-dihydro-9-arylacridin-1(2H)-ones and their derivatives: in-vitro antifungal, antibacterial and antioxidant evaluations
  68. Production of Methanol as a Fuel Energy from CO2 Present in Polluted Seawater - A Photocatalytic Outlook
  69. Study of different extraction methods on finger print and fatty acid of raw beef fat using fourier transform infrared and gas chromatography-mass spectrometry
  70. Determination of trace fluoroquinolones in water solutions and in medicinal preparations by conventional and synchronous fluorescence spectrometry
  71. Extraction and determination of flavonoids in Carthamus tinctorius
  72. Therapeutic Application of Zinc and Vanadium Complexes against Diabetes Mellitus a Coronary Disease: A review
  73. Study of calcined eggshell as potential catalyst for biodiesel formation using used cooking oil
  74. Manganese oxalates - structure-based Insights
  75. Topological Indices of H-Naphtalenic Nanosheet
  76. Long-Term Dissolution of Glass Fibers in Water Described by Dissolving Cylinder Zero-Order Kinetic Model: Mass Loss and Radius Reduction
  77. Topological study of the para-line graphs of certain pentacene via topological indices
  78. A brief insight into the prediction of water vapor transmissibility in highly impermeable hybrid nanocomposites based on bromobutyl/epichlorohydrin rubber blends
  79. Comparative sulfite assay by voltammetry using Pt electrodes, photometry and titrimetry: Application to cider, vinegar and sugar analysis
  80. MicroRNA delivery mediated by PEGylated polyethylenimine for prostate cancer therapy
  81. Reversible Fluorescent Turn-on Sensors for Fe3+ based on a Receptor Composed of Tri-oxygen Atoms of Amide Groups in Water
  82. Sonocatalytic degradation of methyl orange in aqueous solution using Fe-doped TiO2 nanoparticles under mechanical agitation
  83. Hydrotalcite Anchored Ruthenium Catalyst for CO2 Hydrogenation Reaction
  84. Production and Analysis of Recycled Ammonium Perrhenate from CMSX-4 superalloys
  85. Topical Issue on Agriculture
  86. New phosphorus biofertilizers from renewable raw materials in the aspect of cadmium and lead contents in soil and plants
  87. Survey of content of cadmium, calcium, chromium, copper, iron, lead, magnesium, manganese, mercury, sodium and zinc in chamomile and green tea leaves by electrothermal or flame atomizer atomic absorption spectrometry
  88. Biogas digestate – benefits and risks for soil fertility and crop quality – an evaluation of grain maize response
  89. A numerical analysis of heat transfer in a cross-current heat exchanger with controlled and newly designed air flows
  90. Freshwater green macroalgae as a biosorbent of Cr(III) ions
  91. The main influencing factors of soil mechanical characteristics of the gravity erosion environment in the dry-hot valley of Jinsha river
  92. Free amino acids in Viola tricolor in relation to different habitat conditions
  93. The influence of filler amount on selected properties of new experimental resin dental composite
  94. Effect of poultry wastewater irrigation on nitrogen, phosphorus and carbon contents in farmland soil
  95. Response of spring wheat to NPK and S fertilization. The content and uptake of macronutrients and the value of ionic ratios
  96. The Effect of Macroalgal Extracts and Near Infrared Radiation on Germination of Soybean Seedlings: Preliminary Research Results
  97. Content of Zn, Cd and Pb in purple moor-grass in soils heavily contaminated with heavy metals around a zinc and lead ore tailing landfill
  98. Topical Issue on Research for Natural Bioactive Products
  99. Synthesis of (±)-3,4-dimethoxybenzyl-4-methyloctanoate as a novel internal standard for capsinoid determination by HPLC-ESI-MS/MS(QTOF)
  100. Repellent activity of monoterpenoid esters with neurotransmitter amino acids against yellow fever mosquito, Aedes aegypti
  101. Effect of Flammulina velutipes (golden needle mushroom, eno-kitake) polysaccharides on constipation
  102. Bioassay-directed fractionation of a blood coagulation factor Xa inhibitor, betulinic acid from Lycopus lucidus
  103. Antifungal and repellent activities of the essential oils from three aromatic herbs from western Himalaya
  104. Chemical composition and microbiological evaluation of essential oil from Hyssopus officinalis L. with white and pink flowers
  105. Bioassay-guided isolation and identification of Aedes aegypti larvicidal and biting deterrent compounds from Veratrum lobelianum
  106. α-Terpineol, a natural monoterpene: A review of its biological properties
  107. Utility of essential oils for development of host-based lures for Xyleborus glabratus (Coleoptera: Curculionidae: Scolytinae), vector of laurel wilt
  108. Phenolic composition and antioxidant potential of different organs of Kazakh Crataegus almaatensis Pojark: A comparison with the European Crataegus oxyacantha L. flowers
  109. Isolation of eudesmane type sesquiterpene ketone from Prangos heyniae H.Duman & M.F.Watson essential oil and mosquitocidal activity of the essential oils
  110. Comparative analysis of the polyphenols profiles and the antioxidant and cytotoxicity properties of various blue honeysuckle varieties
  111. Special Issue on ICCESEN 2017
  112. Modelling world energy security data from multinomial distribution by generalized linear model under different cumulative link functions
  113. Pine Cone and Boron Compounds Effect as Reinforcement on Mechanical and Flammability Properties of Polyester Composites
  114. Artificial Neural Network Modelling for Prediction of SNR Effected by Probe Properties on Ultrasonic Inspection of Austenitic Stainless Steel Weldments
  115. Calculation and 3D analyses of ERR in the band crack front contained in a rectangular plate made of multilayered material
  116. Improvement of fuel properties of biodiesel with bioadditive ethyl levulinate
  117. Properties of AlSi9Cu3 metal matrix micro and nano composites produced via stir casting
  118. Investigation of Antibacterial Properties of Ag Doped TiO2 Nanofibers Prepared by Electrospinning Process
  119. Modeling of Total Phenolic contents in Various Tea samples by Experimental Design Methods
  120. Nickel doping effect on the structural and optical properties of indium sulfide thin films by SILAR
  121. The effect mechanism of Ginnalin A as a homeopathic agent on various cancer cell lines
  122. Excitation functions of proton induced reactions of some radioisotopes used in medicine
  123. Oxide ionic conductivity and microstructures of Pr and Sm co-doped CeO2-based systems
  124. Rapid Synthesis of Metallic Reinforced in Situ Intermetallic Composites in Ti-Al-Nb System via Resistive Sintering
  125. Oxidation Behavior of NiCr/YSZ Thermal Barrier Coatings (TBCs)
  126. Clustering Analysis of Normal Strength Concretes Produced with Different Aggregate Types
  127. Magnetic Nano-Sized Solid Acid Catalyst Bearing Sulfonic Acid Groups for Biodiesel Synthesis
  128. The biological activities of Arabis alpina L. subsp. brevifolia (DC.) Cullen against food pathogens
  129. Humidity properties of Schiff base polymers
  130. Free Vibration Analysis of Fiber Metal Laminated Straight Beam
  131. Comparative study of in vitro antioxidant, acetylcholinesterase and butyrylcholinesterase activity of alfalfa (Medicago sativa L.) collected during different growth stages
  132. Isothermal Oxidation Behavior of Gadolinium Zirconate (Gd2Zr2O7) Thermal Barrier Coatings (TBCs) produced by Electron Beam Physical Vapor Deposition (EB-PVD) technique
  133. Optimization of Adsorption Parameters for Ultra-Fine Calcite Using a Box-Behnken Experimental Design
  134. The Microstructural Investigation of Vermiculite-Infiltrated Electron Beam Physical Vapor Deposition Thermal Barrier Coatings
  135. Modelling Porosity Permeability of Ceramic Tiles using Fuzzy Taguchi Method
  136. Experimental and theoretical study of a novel naphthoquinone Schiff base
  137. Physicochemical properties of heat treated sille stone for ceramic industry
  138. Sand Dune Characterization for Preparing Metallurgical Grade Silicon
  139. Catalytic Applications of Large Pore Sulfonic Acid-Functionalized SBA-15 Mesoporous Silica for Esterification
  140. One-photon Absorption Characterizations, Dipole Polarizabilities and Second Hyperpolarizabilities of Chlorophyll a and Crocin
  141. The Optical and Crystallite Characterization of Bilayer TiO2 Films Coated on Different ITO layers
  142. Topical Issue on Bond Activation
  143. Metal-mediated reactions towards the synthesis of a novel deaminolysed bisurea, dicarbamolyamine
  144. The structure of ortho-(trifluoromethyl)phenol in comparison to its homologues – A combined experimental and theoretical study
  145. Heterogeneous catalysis with encapsulated haem and other synthetic porphyrins: Harnessing the power of porphyrins for oxidation reactions
  146. Recent Advances on Mechanistic Studies on C–H Activation Catalyzed by Base Metals
  147. Reactions of the organoplatinum complex [Pt(cod) (neoSi)Cl] (neoSi = trimethylsilylmethyl) with the non-coordinating anions SbF6– and BPh4–
  148. Erratum
  149. Investigation on Two Compounds of O, O’-dithiophosphate Derivatives as Corrosion Inhibitors for Q235 Steel in Hydrochloric Acid Solution
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Heruntergeladen am 6.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/chem-2018-0074/html
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