Startseite Quercitrin protects human bronchial epithelial cells from oxidative damage
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Quercitrin protects human bronchial epithelial cells from oxidative damage

  • Dan Yu , Fan Wang , Shuming Ye , Shuo Yang , Ning Yu , Xinyan Zhou und Nian Zhang EMAIL logo
Veröffentlicht/Copyright: 22. Februar 2022
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Open Medicine
Aus der Zeitschrift Open Medicine Band 17 Heft 1

Abstract

Chronic obstructive pulmonary disease (COPD) is mainly caused by cigarette smoking (CS), with oxidative stress being one key component during its pathogenesis. This study aimed to investigate the effects of quercitrin (QE) on cigarette smoke extract (CSE)-induced cell apoptosis and oxidative stress in human bronchial epithelial cells (HBECs) and its underlying mechanism. HBECs were treated with 2% CSE for 24 h to establish in vitro COPD cellular models. CCK-8 assay and flow cytometry analysis were performed to evaluate cell viability and apoptosis, respectively. Western blotting was applied to examine protein levels and ELISA kits were used to examine contents of the indicated oxidant/antioxidant markers. The results demonstrated that CSE promoted apoptosis and suppressed viability of HBECs and QE reversed these effects. CSE caused increase in T-AOC, superoxide dismutase, and glutathione (GSH) peroxidase contents and decrease in MDA, reactive oxygen species , and GSH contents in HBECs, which were rescued by QE treatment. The CSE-induced Nrf2 nuclear translocation and elevation of NAD(P)H: quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1) expression were also reversed by QE in HBECs. The mitogen-activated protein kinase (MAPK) signaling was activated by CSE and further suppressed by QE in HBECs. Collectively, QE exerts a protective role in HBECs against cell apoptosis and oxidative damage via inactivation of the Nrf2/HO-1/NQO1 pathway and the MAPK/ERK pathway.

Keywords: chronic obstructive pulmonary disease; quercitrin; oxidative stress; the Nrf2/HO-1/NQO1 pathway; the MAPK/ERK pathway

1 Introduction

It has been estimated that chronic obstructive pulmonary disease (COPD) ranks third among leading causes of mortality by 2020 [1]. COPD is characterized by chronic airway inflammation and progressively irreversible airflow limitation [2]. Cigarette smoking (CS) is considered as the predominant factor, accounting for approximately 80–90% of all COPD cases [3]. Oxidative stress is one key component in COPD pathogenesis [4]. Oxidative stress refers to the imbalance of oxidation and antioxidation in the body attacked by harmful stimulating factors [5]. It can directly damage lung tissues and cause gene expression of proinflammatory mediator, exudation of inflammatory cells, and oxidative inactivation of protease, thereby facilitating the development of COPD [6]. Superoxide dismutase (SOD), reactive oxygen species (ROS), glutathione (GSH), and GSH peroxidase (GSH-Px) are markers of oxidative stress [7]. Heme oxygenase-1 (HO-1) is a crucial endogenous enzyme that catalyzes heme decomposition and generates carbon monoxide, biliverdin, and ferrous iron to modulate apoptosis, inflammation, and oxidative stress [8]. NAD(P)H: quinone oxidoreductase 1 (NQO1) is also a significant enzyme related to cell apoptosis and oxidative stress [9,10]. Therefore, exploring the mechanism underlying the oxidative stress in COPD is of great significance for clinical treatment of COPD.

Flavonoids possessing anti-inflammatory and antioxidant activities, easily infiltrate the blood–brain barrier and provide neuroprotection in a series of animal and cellular models of neurological diseases [11,12]. Quercitrin (QE) (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl6-deoxyalpha-l-mannopyranoside) is a class of natural flavonoids in the leaves, flowers, and fruits of numerous plants [13,14]. QE was demonstrated to have anti-apoptosis, anti-inflammatory, and anti-oxidative effects [15,16]. Previous reports showed that QE markedly attenuated inflammatory response in the livers of mice as well as reduced acute systemic inflammation in lipopolysaccharide (LPS)-induced models [17]. QE can alleviate apoptosis and inflammation in cytokine-induced models [18]. It has been revealed that QE displays organ protective properties in the kidney, liver, and pancreas by elevating the antioxidant status [19]. Therefore, we aimed to explore the function of QE on apoptosis and oxidative stress in COPD.

Mitogen-activated protein kinase (MAPK) signaling pathway plays a key role in regulating lung inflammation, and can be activated in a cell-stimulus-specific manner [20]. The activation of MAPK signaling pathway involving p38 and ERK has been reported in cigarette smoke extract (CSE)-exposed human bronchial epithelial cells (HBECs) or in COPD patients [21,22]. We intended to explore whether this signaling is involved in cell apoptosis and oxidative stress during COPD progression.

Herein we intended to figure out the specific role of QE in COPD. We established CSE-stimulated cellular models of COPD to elucidate the potential mechanisms of QE on apoptosis and oxidative stress in HBECs, which may provide a potential new direction for COPD treatment.

2 Materials and methods

2.1 CSE preparation

The smoke from 10 cigarettes was bubbled through 25 mL of media. The suspension was titrated to pH 7.4, filter-sterilized, and regarded as 100% CSE. The CSE sample was diluted with phosphate buffer saline (PBS, Invitrogen, Carlsbad, CA, USA) to gain concentrations of 2%, and CSE was frozen in aliquots at −80°C.

2.2 Cell culture and treatment

HBECs were obtained from Chinese Academy of Cell Resource Center (Shanghai, China) and were incubated in Roswell Park Memorial Institute 1640 (RPMI-1640; Sigma-Aldrich, St. Louis, MO, USA) medium containing 10% fetal bovine serum (FBS; Invitrogen) in 5% CO2 at 37°C. QE was purchased from Sigma-Aldrich and dissolved in dimethyl sulfoxide (final concentration 0.05%) for cell culture. Cells were treated with QE at different concentrations (0 or 22.4 µg/mL) for 24 h. CSE cellular models were divided into four groups: saline + Con group (0% CSE and 0 µg/mL QE), saline + CSE group (2% CSE and 0 µg/mL QE), QE + Con group (0% CSE and 22.4 µg/mL QE), and QE + CSE group (2% CSE and 22.4 µg/mL QE).

2.3 CCK-8 assay

The viability of HBECs was measured by CCK-8 assay. In brief, the cells were dispersed evenly in the medium and then seeded at a density of 4 × 104 cells/well in 96-well plates. Next day, after the cells were treated with indicated reagents, 10 µL of CCK-8 solution (Sigma-Aldrich) was added into each well, followed by 2 h of incubation. The optical density at 450 nm was determined using a microplate reader (Thermo Scientific, Rockford, IL, USA).

2.4 Flow cytometry analysis

Flow cytometry was used to evaluate the apoptosis of HBECs. Cells at a density of 5 × 104 cells/well were seeded into 6-well plates, and then harvested and washed. After indicated treatment, cells were resuspended and stained with 5 mL of Annexin V-fluorescein isothiocyanate (FITC) and 1 mL of Propidium Iodide (PI) (Beyotime Biotechnology, Beijing, China) in the dark at room temperature for 10 min. Cell apoptosis rate was analyzed using a FACScan flow cytometry (BD Bioscience, San Jose, CA, USA).

2.5 Western blot analysis

Proteins were extracted by RIPA lysis buffer (Beyotime Biotechnology). A nuclear/cytoplasmic isolation kit (Beyotime Biotechnology) was used to obtain cytoplasmic and nuclear extracts. Protein extracts were determined using the BCA assay kit (Sigma-Aldrich). Samples containing equal amount of protein were separated in 10% sodium dodecyl sulfate polyacrylamide gel electrophoresis and transferred onto a nitrocellulose membrane. After blocking with 5% non-fat milk, the membrane was incubated with primary antibodies including anti-Bcl-2 (ab32124, 1:1,000, Abcam, Cambridge, UK), anti-Bax (ab182733, 1:2,000, Abcam), anti-cleaved caspase-3 (ab2302, 1:500, Abcam), anti-HO-1 (ab52947, 1:2,000, Abcam), anti-NQO1 (ab80588, 1:10,000, Abcam), anti-Nrf2 (ab137550, 1:500, Abcam), anti-ERK (ab32537, 1:1,000, Abcam), anti-pERK (ab76299, 1:5,000, Abcam), anti-p38 (ab182453, 1:1,000, Abcam), anti-p-p38 (ab178867, 1:1,000, Abcam), anti-Lamin A/C (ab133256, 1:10,000, Abcam), and anti-β-actin (ab8227, 1:3,000, Abcam) overnight at 4°C. Then, the membranes were incubated with horseradish peroxidase-conjugated secondary antibodies for 2 h at room temperature after being washed with TBST for three times. The signals of protein bands were observed by a chemiluminescence detection system (Thermo Fisher Scientific). Protein expression was normalized to Lamin A/C for nuclear protein and β-actin for total/cytoplasmic protein. The experiment was repeated in triplicate independently.

2.6 Measurement of oxidative stress markers

Commercially available ELISA kits (Thermo Scientific) were used to measure total antioxidant capacity (T-AOC), malondialdehyde (MDA), ROS, GSH, SOD, and GSH-Px in HBECs. Results were normalized to protein concentration in HBECs.

2.7 Statistical analysis

Data are presented as the mean value ± standard deviation (SD) from at least three independent experiments. Comparisons between two groups or among multiple groups were analyzed by Student’s t test or one-way analysis of variance (ANOVA) followed by Tukey’s post hoc test using software Prism 7.0 (GraphPad). P < 0.05 was considered statistically significant.

3 Results

3.1 The molecular structure formula of QE

First, we discovered the molecular structure formula of QE, as shown in Figure 1. QE solubility in polar solvents and its absorption were improved by the sugar portion bound to the aglycone portion [23].

Figure 1 The molecular structure formula of QE.
Figure 1

The molecular structure formula of QE.

3.2 QE rescues the decreased viability and increased apoptosis of CSE-treated HBECs

To explore the biological function of QE in COPD, we mimicked COPD characteristics by establishing CSE-induced cellular models. HBECs were treated with 2% CSE for 24 h. First, CCK-8 assay was performed to evaluate cell viability. The results suggested that CSE treatment attenuated cell viability and QE stimulation partially restored cell viability (Figure 2a). Moreover, flow cytometry analysis suggested that the apoptosis of HBECs was promoted by CES stimulation and rescued by QE treatment (Figure 2b and c). In addition, western blotting depicted that Bax and cleaved caspase-3 protein levels in HBECs were upregulated by CSE stimulation, while Bcl-2 protein level was downregulated after CSE treatment. However, the changes in the protein levels of Bax, Bcl-2, and cleaved caspase-3 caused by CSE stimulation were reversed by QE treatment (Figure 2d–g). Collectively, QE can rescue CSE-induced reduction in lung epithelial cell viability and elevation in cell apoptosis.

Figure 2 Effects of QE on the viability and apoptosis of CSE-treated HBECs. (a) CCK-8 assay was applied to measure lung epithelial cell viability in saline + Con group, saline + CSE group, QE + Con group, and QE + CSE group. (b and c) Flow cytometry analysis was used to evaluate lung epithelial cell apoptosis in each group. (d–g) Western blotting was performed to detect protein levels of Bax, Bcl-2, and cleaved caspase-3 in HBECs in each group. *p < 0.05, **p < 0.01, and ***p < 0.001.
Figure 2

Effects of QE on the viability and apoptosis of CSE-treated HBECs. (a) CCK-8 assay was applied to measure lung epithelial cell viability in saline + Con group, saline + CSE group, QE + Con group, and QE + CSE group. (b and c) Flow cytometry analysis was used to evaluate lung epithelial cell apoptosis in each group. (d–g) Western blotting was performed to detect protein levels of Bax, Bcl-2, and cleaved caspase-3 in HBECs in each group. *p < 0.05, **p < 0.01, and ***p < 0.001.

3.3 QE rescues the CSE-induced oxidant/antioxidant imbalance in HBECs

To investigate the anti-oxidative capacity of QE, the content of oxidative/anti-oxidative markers in HBECs were evaluated using ELISA kits. Levels of T-AOC, SOD, and GSH-Px were reduced, while levels of MDA, ROS, and GSH were elevated by CSE exposure (Figure 3a–f). This indicated that CSE led to oxidant damage in HBECs. However, the subsequent QE treatment rescued the elevation of MDA, ROS, and GSH contents as well as reduction in T-AOC, SOD, and GSH-Px contents caused by CSE (Figure 3a–f). Overall, QE alleviates CSE-induced oxidative damage in HBECs.

Figure 3 Effects of QE on the contents of oxidative/anti-oxidative markers in CSE-treated HBECs. (a–f) ELISA was used to measure the concentrations of T-AOC, MDA, ROS, GSH, SOD, and GSH-Px in HBECs in saline + Con group, saline + CSE group, QE + Con group, and QE + CSE group. *p < 0.05 and **p < 0.01.
Figure 3

Effects of QE on the contents of oxidative/anti-oxidative markers in CSE-treated HBECs. (a–f) ELISA was used to measure the concentrations of T-AOC, MDA, ROS, GSH, SOD, and GSH-Px in HBECs in saline + Con group, saline + CSE group, QE + Con group, and QE + CSE group. *p < 0.05 and **p < 0.01.

3.4 QE suppresses CSE-induced activation of Nrf2 and antioxidant enzymes HO-1 and NQO-1 in HBECs

Subsequently, we explored the influence of QE on enzyme expression. Through western blotting, we found that CSE treatment markedly upregulated NQO1 and HO-1 protein expression in HBECs compared to saline + Con group, while NQO1 and HO-1 protein levels were significantly decreased in QE + CSE group vs saline + CSE group. QE alone had no significant effect on NQO1 and HO-1 protein level (Figure 4a). Next we evaluated the influence of QE on Nrf2 translocation under CSE treatment since Nrf2 is a key regulator of cytoprotective genes in response to oxidative stress [24]. Nrf2 was observed translocating from cytoplasmic fractions to nuclear fractions in saline + CSE group, while the translocation was rescued by QE treatment in HBECs (Figure 4b). The levels of both cytoplasmic and nuclear Nrf2 showed no significant difference in Saline + Con group and QE + Con group, suggesting that QE alone had no marked effect on CSE-induced Nrf2 translocation. In summary, QE suppresses CSE-induced activation of Nrf2 and antioxidant enzymes HO-1 and NQO-1 in HBECs, thereby alleviating CSE-induced oxidative damage.

Figure 4 Effects of QE on CSE-induced HO-1, NQO1 enzyme expression, and the Nrf2 translocation in HBECs. (a) Western blotting was used to examine protein levels of NQO1 and HO-1 in HBECs in saline + Con group, saline + CSE group, QE + Con group, and QE + CSE group. (b) Western blotting was used to detect cytoplasmic and nuclear Nrf2 protein expression in HBECs under indicated treatment. *p < 0.05, **p < 0.01, and ***p < 0.001.
Figure 4

Effects of QE on CSE-induced HO-1, NQO1 enzyme expression, and the Nrf2 translocation in HBECs. (a) Western blotting was used to examine protein levels of NQO1 and HO-1 in HBECs in saline + Con group, saline + CSE group, QE + Con group, and QE + CSE group. (b) Western blotting was used to detect cytoplasmic and nuclear Nrf2 protein expression in HBECs under indicated treatment. *p < 0.05, **p < 0.01, and ***p < 0.001.

3.5 QE inactivates the MAPK/ERK signaling pathway in HBECs

We further investigated the underlying mechanism of oxidative stress and apoptosis in HBECs. Previous report has demonstrated that several signaling pathways regulate CSE-induced oxidative stress, involving the MAPK signaling pathway [25]. Western blotting illustrated that the increased phosphorylation of p38 and ERK in HBECs was observed under CSE stimulation in saline + CSE group, which was reversed by QE treatment in QE + CSE group (Figure 5a). Therefore, QE inhibits CSE-induced activation of the MAPK/ERK signaling pathway in HBECs.

Figure 5 Effects of QE on the MAPK/ERK signaling pathway in CSE-treated HBECs. (a) Western blotting was performed to assess protein levels of ERK, p-ERK, p38, and p-p38 in HBECs in saline + Con group, saline + CSE group, QE + Con group, and QE + CSE group. **p < 0.01 and ***p < 0.001.
Figure 5

Effects of QE on the MAPK/ERK signaling pathway in CSE-treated HBECs. (a) Western blotting was performed to assess protein levels of ERK, p-ERK, p38, and p-p38 in HBECs in saline + Con group, saline + CSE group, QE + Con group, and QE + CSE group. **p < 0.01 and ***p < 0.001.

4 Discussion

In the present study, we demonstrated the protective influence of QE on CSE-induced apoptosis and oxidative stress in HBECs via Nrf2 and MAPK pathways. In our report, we found that CSE promoted apoptosis and induced oxidant/antioxidant imbalance in HBECs, which were rescued by QE treatment. These findings suggested that QE protects HBECs from CSE-induced apoptosis and oxidative damage.

The oxidatant/antioxidant balance depends on the regulation of the endogenous antioxidant defense system [26]. Herein we found that T-AOC, an indicator of total antioxidant status that reflects the degree of oxidative damage in cells [27], was significantly downregulated in CSE-treated HBECs, while antagonized by QE administration. The content of MDA often reflects the degree of lipid peroxidation in tissues and indirectly shows the degree of cell damage [28]. In our report, we discovered a significant increase in MDA content in HBECs under CSE treatment. Nevertheless, as expected, our results indicated that MDA accumulation in HBECs due to CSE was reduced by QE stimulation. Previous reports demonstrated that excessive production of ROS or inadequate anti-oxidative capacity may change the cellular redox balance, thus causing oxidative stress [29]. ROS emitted by cigarette smoke and produced from the structural or inflammatory cells results in direct or indirect damage of lipids, proteins, and nucleic acids, and participate in the pathogenesis of many diseases [30,31,32]. Consistent with this notion, we found that the ROS content in the CSE-treated HBECs was increased; however, the increased ROS was reversed by QE application. In mammalian cells, GSH serves as a main antioxidant that directly or indirectly scavenges free radicals and other reactive nitrogen species via enzymatic reaction [33]. This report revealed that CSE exposure caused a significant increase in GSH concentration, and QE reversed this effect in HBECs. Additionally, SOD enzymes prevent the production of toxic hydroxyl radical via scavenging superoxide anion into hydrogen peroxide and molecular oxygen [34]. In our report, SOD content was reduced by CSE and rescued by QE in HBECs. Furthermore, it has been revealed that GSH-Px is the most abundant and appears to have a major role in ROS defense based on in vitro studies [35]. Herein we found that GSH-Px showed decrease under CSE stimulation and further showed reversal under QE treatment in HBECs. These findings suggested that QE alleviates CSE-induced oxidative stress injury in HBECs.

Nrf2 is one of the main cellular defense lines against oxidative stress [36]. Nrf2, as a key transcription factor regulating antioxidant stress, plays an important role in inducing the body’s antioxidant response [37]. Under steady state conditions, unactivated Nrf2 exists in the cytoplasm and is linked to the cytoplasmic protein Keap1 [38]. Keap1 inhibits Nrf2 by retaining Nrf2 in the cytoplasm and enhancing its proteasome degradation through ubiquitination [38]. Under oxidative stress, Nrf2 will be released from the Keap1/Nrf2 complex and transferred to the nucleus, thereby activating Nrf2 and its downstream-regulated genes in the nucleus, including HO-1 and NQO1 [39]. HO-1 is a crucial antioxidative enzyme, which catalyzes the decomposition of heme and generates biliverdin and carbon monoxide, eliminating ROS and maintaining the intracellular redox homeostasis [40]. NQO1 is a quinone oxidoreductase that prevents the production of semiquinone radicals, which are important sources of ROS [41,42]. In animals, Nrf2 activation has been found to attenuate CSE-induced emphysema and airway inflammation in mice [30]. QE was demonstrated to mediate the expression of Nrf2 and the activity of antioxidant response element (ARE)-reporter gene, thus regulating Nrf2/ARE-mediated antioxidant defense mechanism [43]. Previously, in LPS-induced lung injury in mice, the protein level of Cytosol Nrf2 was reduced after LPS treatment, while it was partially restored after GRh2 treatment, which indicated that GRh2 showed antioxidant effects by inhibiting Nrf2 nuclear translocation [44]. In the present study, we discovered that Cytosol Nrf2 was reduced, while Nucleus Nfr2 was elevated after CSE treatment, which suggested that CSE induced oxidative stress and the subsequent Nrf2 nuclear translocation. Nevertheless, QE reversed the effects of CSE on Nrf2. Additionally, the elevation in HO-1 and NQO1 levels caused by CSE was restored by QE treatment. Therefore, QE suppressed CSE-induced oxidative stress, thereby restraining Nrf2 nuclear translocation and activation antioxidant enzymes HO-1 and NQO-1. Furthermore, the MAPK pathway is one of the signaling pathway in lung diseases and is closely associated with oxidative stress [45,46]. QE has been reported to suppress the phosphorylation of p38 MAPK and ERK, and downregulate MAPK signaling pathways before [47,48]. In our research, the protein level of p-ERK and p-p38 was elevated by CSE and attenuated by QE, which indicated the suppressive function of QE on activation of the MAPK pathway. These findings suggested that QE exerts a protective role against oxidative damage and apoptosis in HBECs through the inactivation of the Nrf2 and MAPK pathways.

There also exist some limitations in this study. First, the function of QE on cell apoptosis and oxidative stress in COPD was evaluated only by treating HBECs with CSE to establish in vitro cellular model. The conduction of in vivo experiments using animal models of COPD will make our results more convincing. Second, chronic inflammation is also a crucial factor attributing to the pathogenesis of COPD. QE extracted from Houttuynia cordata used for treating inflammation-related disorders was reported to markedly repress lung inflammatory response in the mouse model of LPS-induced acute lung injury [49]. However, our study only investigated and proved that QE can inhibit CSE-induced cell apoptosis and oxidative stress in HBECs. Therefore, whether QE protects HBECs from CSE-induced inflammation required further exploration in future studies.

In conclusion, our research innovatively put forward and confirmed that QE can reverse CSE-induced oxidative stress and apoptosis in HBECs by inactivating the Nrf2 and MAPK signaling pathways. This report suggested that QE has the potential to be developed as an effective agent for improving clinical treatment of COPD.

These authors contributed equally to the work.

Acknowledgements

Thanks to all lab members involved in this study.

  1. Funding information: The work was supported by Health Commission of Hubei Provincial (WJ2019H415) and Wuhan Municipal Health Commission (WZ19A08): A preliminary study on the mechanism of the treatment of COPD with the method of resolving phlegm, promoting blood circulation.

  2. Conflict of interest: Authors state no conflict of interest.

  3. Data availability statement: The datasets used or analyzed during the current study are available from the corresponding author on reasonable request.

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Received: 2021-07-14
Revised: 2021-11-19
Accepted: 2021-11-23
Published Online: 2022-02-22

© 2022 Dan Yu et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Artikel in diesem Heft

  1. Research Articles
  2. AMBRA1 attenuates the proliferation of uveal melanoma cells
  3. A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma
  4. Differences in complications between hepatitis B-related cirrhosis and alcohol-related cirrhosis
  5. Effect of gestational diabetes mellitus on lipid profile: A systematic review and meta-analysis
  6. Long noncoding RNA NR2F1-AS1 stimulates the tumorigenic behavior of non-small cell lung cancer cells by sponging miR-363-3p to increase SOX4
  7. Promising novel biomarkers and candidate small-molecule drugs for lung adenocarcinoma: Evidence from bioinformatics analysis of high-throughput data
  8. Plasmapheresis: Is it a potential alternative treatment for chronic urticaria?
  9. The biomarkers of key miRNAs and gene targets associated with extranodal NK/T-cell lymphoma
  10. Gene signature to predict prognostic survival of hepatocellular carcinoma
  11. Effects of miRNA-199a-5p on cell proliferation and apoptosis of uterine leiomyoma by targeting MED12
  12. Does diabetes affect paraneoplastic thrombocytosis in colorectal cancer?
  13. Is there any effect on imprinted genes H19, PEG3, and SNRPN during AOA?
  14. Leptin and PCSK9 concentrations are associated with vascular endothelial cytokines in patients with stable coronary heart disease
  15. Pericentric inversion of chromosome 6 and male fertility problems
  16. Staple line reinforcement with nebulized cyanoacrylate glue in laparoscopic sleeve gastrectomy: A propensity score-matched study
  17. Retrospective analysis of crescent score in clinical prognosis of IgA nephropathy
  18. Expression of DNM3 is associated with good outcome in colorectal cancer
  19. Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation
  20. CRRT influences PICCO measurements in febrile critically ill patients
  21. SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis
  22. lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells
  23. circ_AKT3 knockdown suppresses cisplatin resistance in gastric cancer
  24. Prognostic value of nicotinamide N-methyltransferase in human cancers: Evidence from a meta-analysis and database validation
  25. GPC2 deficiency inhibits cell growth and metastasis in colon adenocarcinoma
  26. A pan-cancer analysis of the oncogenic role of Holliday junction recognition protein in human tumors
  27. Radiation increases COL1A1, COL3A1, and COL1A2 expression in breast cancer
  28. Association between preventable risk factors and metabolic syndrome
  29. miR-29c-5p knockdown reduces inflammation and blood–brain barrier disruption by upregulating LRP6
  30. Cardiac contractility modulation ameliorates myocardial metabolic remodeling in a rabbit model of chronic heart failure through activation of AMPK and PPAR-α pathway
  31. Quercitrin protects human bronchial epithelial cells from oxidative damage
  32. Smurf2 suppresses the metastasis of hepatocellular carcinoma via ubiquitin degradation of Smad2
  33. circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury
  34. Sonoclot’s usefulness in prediction of cardiopulmonary arrest prognosis: A proof of concept study
  35. Four drug metabolism-related subgroups of pancreatic adenocarcinoma in prognosis, immune infiltration, and gene mutation
  36. Decreased expression of miR-195 mediated by hypermethylation promotes osteosarcoma
  37. LMO3 promotes proliferation and metastasis of papillary thyroid carcinoma cells by regulating LIMK1-mediated cofilin and the β-catenin pathway
  38. Cx43 upregulation in HUVECs under stretch via TGF-β1 and cytoskeletal network
  39. Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey
  40. Histopathologic findings on removed stomach after sleeve gastrectomy. Do they influence the outcome?
  41. Analysis of the expression and prognostic value of MT1-MMP, β1-integrin and YAP1 in glioma
  42. Optimal diagnosis of the skin cancer using a hybrid deep neural network and grasshopper optimization algorithm
  43. miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells
  44. Clinical value of SIRT1 as a prognostic biomarker in esophageal squamous cell carcinoma, a systematic meta-analysis
  45. circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8
  46. miR-22-5p regulates the self-renewal of spermatogonial stem cells by targeting EZH2
  47. hsa-miR-340-5p inhibits epithelial–mesenchymal transition in endometriosis by targeting MAP3K2 and inactivating MAPK/ERK signaling
  48. circ_0085296 inhibits the biological functions of trophoblast cells to promote the progression of preeclampsia via the miR-942-5p/THBS2 network
  49. TCD hemodynamics findings in the subacute phase of anterior circulation stroke patients treated with mechanical thrombectomy
  50. Development of a risk-stratification scoring system for predicting risk of breast cancer based on non-alcoholic fatty liver disease, non-alcoholic fatty pancreas disease, and uric acid
  51. Tollip promotes hepatocellular carcinoma progression via PI3K/AKT pathway
  52. circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis
  53. Human amniotic fluid as a source of stem cells
  54. lncRNA NONRATT013819.2 promotes transforming growth factor-β1-induced myofibroblastic transition of hepatic stellate cells by miR24-3p/lox
  55. NORAD modulates miR-30c-5p-LDHA to protect lung endothelial cells damage
  56. Idiopathic pulmonary fibrosis telemedicine management during COVID-19 outbreak
  57. Risk factors for adverse drug reactions associated with clopidogrel therapy
  58. Serum zinc associated with immunity and inflammatory markers in Covid-19
  59. The relationship between night shift work and breast cancer incidence: A systematic review and meta-analysis of observational studies
  60. LncRNA expression in idiopathic achalasia: New insight and preliminary exploration into pathogenesis
  61. Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway
  62. Moscatilin suppresses the inflammation from macrophages and T cells
  63. Zoledronate promotes ECM degradation and apoptosis via Wnt/β-catenin
  64. Epithelial-mesenchymal transition-related genes in coronary artery disease
  65. The effect evaluation of traditional vaginal surgery and transvaginal mesh surgery for severe pelvic organ prolapse: 5 years follow-up
  66. Repeated partial splenic artery embolization for hypersplenism improves platelet count
  67. Low expression of miR-27b in serum exosomes of non-small cell lung cancer facilitates its progression by affecting EGFR
  68. Exosomal hsa_circ_0000519 modulates the NSCLC cell growth and metastasis via miR-1258/RHOV axis
  69. miR-455-5p enhances 5-fluorouracil sensitivity in colorectal cancer cells by targeting PIK3R1 and DEPDC1
  70. The effect of tranexamic acid on the reduction of intraoperative and postoperative blood loss and thromboembolic risk in patients with hip fracture
  71. Isocitrate dehydrogenase 1 mutation in cholangiocarcinoma impairs tumor progression by sensitizing cells to ferroptosis
  72. Artemisinin protects against cerebral ischemia and reperfusion injury via inhibiting the NF-κB pathway
  73. A 16-gene signature associated with homologous recombination deficiency for prognosis prediction in patients with triple-negative breast cancer
  74. Lidocaine ameliorates chronic constriction injury-induced neuropathic pain through regulating M1/M2 microglia polarization
  75. MicroRNA 322-5p reduced neuronal inflammation via the TLR4/TRAF6/NF-κB axis in a rat epilepsy model
  76. miR-1273h-5p suppresses CXCL12 expression and inhibits gastric cancer cell invasion and metastasis
  77. Clinical characteristics of pneumonia patients of long course of illness infected with SARS-CoV-2
  78. circRNF20 aggravates the malignancy of retinoblastoma depending on the regulation of miR-132-3p/PAX6 axis
  79. Linezolid for resistant Gram-positive bacterial infections in children under 12 years: A meta-analysis
  80. Rack1 regulates pro-inflammatory cytokines by NF-κB in diabetic nephropathy
  81. Comprehensive analysis of molecular mechanism and a novel prognostic signature based on small nuclear RNA biomarkers in gastric cancer patients
  82. Smog and risk of maternal and fetal birth outcomes: A retrospective study in Baoding, China
  83. Let-7i-3p inhibits the cell cycle, proliferation, invasion, and migration of colorectal cancer cells via downregulating CCND1
  84. β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis
  85. Possible impact of COVID-19 pandemic and lockdown on suicide behavior among patients in Southeast Serbia
  86. In vitro antimicrobial activity of ozonated oil in liposome eyedrop against multidrug-resistant bacteria
  87. Potential biomarkers for inflammatory response in acute lung injury
  88. A low serum uric acid concentration predicts a poor prognosis in adult patients with candidemia
  89. Antitumor activity of recombinant oncolytic vaccinia virus with human IL2
  90. ALKBH5 inhibits TNF-α-induced apoptosis of HUVECs through Bcl-2 pathway
  91. Risk prediction of cardiovascular disease using machine learning classifiers
  92. Value of ultrasonography parameters in diagnosing polycystic ovary syndrome
  93. Bioinformatics analysis reveals three key genes and four survival genes associated with youth-onset NSCLC
  94. Identification of autophagy-related biomarkers in patients with pulmonary arterial hypertension based on bioinformatics analysis
  95. Protective effects of glaucocalyxin A on the airway of asthmatic mice
  96. Overexpression of miR-100-5p inhibits papillary thyroid cancer progression via targeting FZD8
  97. Bioinformatics-based analysis of SUMOylation-related genes in hepatocellular carcinoma reveals a role of upregulated SAE1 in promoting cell proliferation
  98. Effectiveness and clinical benefits of new anti-diabetic drugs: A real life experience
  99. Identification of osteoporosis based on gene biomarkers using support vector machine
  100. Tanshinone IIA reverses oxaliplatin resistance in colorectal cancer through microRNA-30b-5p/AVEN axis
  101. miR-212-5p inhibits nasopharyngeal carcinoma progression by targeting METTL3
  102. Association of ST-T changes with all-cause mortality among patients with peripheral T-cell lymphomas
  103. LINC00665/miRNAs axis-mediated collagen type XI alpha 1 correlates with immune infiltration and malignant phenotypes in lung adenocarcinoma
  104. The perinatal factors that influence the excretion of fecal calprotectin in premature-born children
  105. Effect of femoral head necrosis cystic area on femoral head collapse and stress distribution in femoral head: A clinical and finite element study
  106. Does the use of 3D-printed cones give a chance to postpone the use of megaprostheses in patients with large bone defects in the knee joint?
  107. lncRNA HAGLR modulates myocardial ischemia–reperfusion injury in mice through regulating miR-133a-3p/MAPK1 axis
  108. Protective effect of ghrelin on intestinal I/R injury in rats
  109. In vivo knee kinematics of an innovative prosthesis design
  110. Relationship between the height of fibular head and the incidence and severity of knee osteoarthritis
  111. lncRNA WT1-AS attenuates hypoxia/ischemia-induced neuronal injury during cerebral ischemic stroke via miR-186-5p/XIAP axis
  112. Correlation of cardiac troponin T and APACHE III score with all-cause in-hospital mortality in critically ill patients with acute pulmonary embolism
  113. LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axis
  114. Endothelial cell-specific molecule 1 (ESM1) promoted by transcription factor SPI1 acts as an oncogene to modulate the malignant phenotype of endometrial cancer
  115. SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial–mesenchymal transition
  116. Visfatin is negatively associated with coronary artery lesions in subjects with impaired fasting glucose
  117. Treatment and outcomes of mechanical complications of acute myocardial infarction during the Covid-19 era: A comparison with the pre-Covid-19 period. A systematic review and meta-analysis
  118. Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland
  119. Oncogenic role of TWF2 in human tumors: A pan-cancer analysis
  120. Mean corpuscular hemoglobin predicts the length of hospital stay independent of severity classification in patients with acute pancreatitis
  121. Association of gallstone and polymorphisms of UGT1A1*27 and UGT1A1*28 in patients with hepatitis B virus-related liver failure
  122. TGF-β1 upregulates Sar1a expression and induces procollagen-I secretion in hypertrophic scarring fibroblasts
  123. Antisense lncRNA PCNA-AS1 promotes esophageal squamous cell carcinoma progression through the miR-2467-3p/PCNA axis
  124. NK-cell dysfunction of acute myeloid leukemia in relation to the renin–angiotensin system and neurotransmitter genes
  125. The effect of dilution with glucose and prolonged injection time on dexamethasone-induced perineal irritation – A randomized controlled trial
  126. miR-146-5p restrains calcification of vascular smooth muscle cells by suppressing TRAF6
  127. Role of lncRNA MIAT/miR-361-3p/CCAR2 in prostate cancer cells
  128. lncRNA NORAD promotes lung cancer progression by competitively binding to miR-28-3p with E2F2
  129. Noninvasive diagnosis of AIH/PBC overlap syndrome based on prediction models
  130. lncRNA FAM230B is highly expressed in colorectal cancer and suppresses the maturation of miR-1182 to increase cell proliferation
  131. circ-LIMK1 regulates cisplatin resistance in lung adenocarcinoma by targeting miR-512-5p/HMGA1 axis
  132. LncRNA SNHG3 promoted cell proliferation, migration, and metastasis of esophageal squamous cell carcinoma via regulating miR-151a-3p/PFN2 axis
  133. Risk perception and affective state on work exhaustion in obstetrics during the COVID-19 pandemic
  134. lncRNA-AC130710/miR-129-5p/mGluR1 axis promote migration and invasion by activating PKCα-MAPK signal pathway in melanoma
  135. SNRPB promotes cell cycle progression in thyroid carcinoma via inhibiting p53
  136. Xylooligosaccharides and aerobic training regulate metabolism and behavior in rats with streptozotocin-induced type 1 diabetes
  137. Serpin family A member 1 is an oncogene in glioma and its translation is enhanced by NAD(P)H quinone dehydrogenase 1 through RNA-binding activity
  138. Silencing of CPSF7 inhibits the proliferation, migration, and invasion of lung adenocarcinoma cells by blocking the AKT/mTOR signaling pathway
  139. Ultrasound-guided lumbar plexus block versus transversus abdominis plane block for analgesia in children with hip dislocation: A double-blind, randomized trial
  140. Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm
  141. Identification of a novel necroptosis-associated miRNA signature for predicting the prognosis in head and neck squamous cell carcinoma
  142. Delayed femoral vein ligation reduces operative time and blood loss during hip disarticulation in patients with extremity tumors
  143. The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients
  144. Longitudinal analysis of factors related to Helicobacter pylori infection in Chinese adults
  145. HOXA10 enhances cell proliferation and suppresses apoptosis in esophageal cancer via activating p38/ERK signaling pathway
  146. Meta-analysis of early-life antibiotic use and allergic rhinitis
  147. Marital status and its correlation with age, race, and gender in prognosis of tonsil squamous cell carcinomas
  148. HPV16 E6E7 up-regulates KIF2A expression by activating JNK/c-Jun signal, is beneficial to migration and invasion of cervical cancer cells
  149. Amino acid profiles in the tissue and serum of patients with liver cancer
  150. Pain in critically ill COVID-19 patients: An Italian retrospective study
  151. Immunohistochemical distribution of Bcl-2 and p53 apoptotic markers in acetamiprid-induced nephrotoxicity
  152. Estradiol pretreatment in GnRH antagonist protocol for IVF/ICSI treatment
  153. Long non-coding RNAs LINC00689 inhibits the apoptosis of human nucleus pulposus cells via miR-3127-5p/ATG7 axis-mediated autophagy
  154. The relationship between oxygen therapy, drug therapy, and COVID-19 mortality
  155. Monitoring hypertensive disorders in pregnancy to prevent preeclampsia in pregnant women of advanced maternal age: Trial mimicking with retrospective data
  156. SETD1A promotes the proliferation and glycolysis of nasopharyngeal carcinoma cells by activating the PI3K/Akt pathway
  157. The role of Shunaoxin pills in the treatment of chronic cerebral hypoperfusion and its main pharmacodynamic components
  158. TET3 governs malignant behaviors and unfavorable prognosis of esophageal squamous cell carcinoma by activating the PI3K/AKT/GSK3β/β-catenin pathway
  159. Associations between morphokinetic parameters of temporary-arrest embryos and the clinical prognosis in FET cycles
  160. Long noncoding RNA WT1-AS regulates trophoblast proliferation, migration, and invasion via the microRNA-186-5p/CADM2 axis
  161. The incidence of bronchiectasis in chronic obstructive pulmonary disease
  162. Integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancer
  163. Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway
  164. Comparison of hospitalized patients with severe pneumonia caused by COVID-19 and influenza A (H7N9 and H1N1): A retrospective study from a designated hospital
  165. lncRNA ZFAS1 promotes intervertebral disc degeneration by upregulating AAK1
  166. Pathological characteristics of liver injury induced by N,N-dimethylformamide: From humans to animal models
  167. lncRNA ELFN1-AS1 enhances the progression of colon cancer by targeting miR-4270 to upregulate AURKB
  168. DARS-AS1 modulates cell proliferation and migration of gastric cancer cells by regulating miR-330-3p/NAT10 axis
  169. Dezocine inhibits cell proliferation, migration, and invasion by targeting CRABP2 in ovarian cancer
  170. MGST1 alleviates the oxidative stress of trophoblast cells induced by hypoxia/reoxygenation and promotes cell proliferation, migration, and invasion by activating the PI3K/AKT/mTOR pathway
  171. Bifidobacterium lactis Probio-M8 ameliorated the symptoms of type 2 diabetes mellitus mice by changing ileum FXR-CYP7A1
  172. circRNA DENND1B inhibits tumorigenicity of clear cell renal cell carcinoma via miR-122-5p/TIMP2 axis
  173. EphA3 targeted by miR-3666 contributes to melanoma malignancy via activating ERK1/2 and p38 MAPK pathways
  174. Pacemakers and methylprednisolone pulse therapy in immune-related myocarditis concomitant with complete heart block
  175. miRNA-130a-3p targets sphingosine-1-phosphate receptor 1 to activate the microglial and astrocytes and to promote neural injury under the high glucose condition
  176. Review Articles
  177. Current management of cancer pain in Italy: Expert opinion paper
  178. Hearing loss and brain disorders: A review of multiple pathologies
  179. The rationale for using low-molecular weight heparin in the therapy of symptomatic COVID-19 patients
  180. Amyotrophic lateral sclerosis and delayed onset muscle soreness in light of the impaired blink and stretch reflexes – watch out for Piezo2
  181. Interleukin-35 in autoimmune dermatoses: Current concepts
  182. Recent discoveries in microbiota dysbiosis, cholangiocytic factors, and models for studying the pathogenesis of primary sclerosing cholangitis
  183. Advantages of ketamine in pediatric anesthesia
  184. Congenital adrenal hyperplasia. Role of dentist in early diagnosis
  185. Migraine management: Non-pharmacological points for patients and health care professionals
  186. Atherogenic index of plasma and coronary artery disease: A systematic review
  187. Physiological and modulatory role of thioredoxins in the cellular function
  188. Case Reports
  189. Intrauterine Bakri balloon tamponade plus cervical cerclage for the prevention and treatment of postpartum haemorrhage in late pregnancy complicated with acute aortic dissection: Case series
  190. A case of successful pembrolizumab monotherapy in a patient with advanced lung adenocarcinoma: Use of multiple biomarkers in combination for clinical practice
  191. Unusual neurological manifestations of bilateral medial medullary infarction: A case report
  192. Atypical symptoms of malignant hyperthermia: A rare causative mutation in the RYR1 gene
  193. A case report of dermatomyositis with the missed diagnosis of non-small cell lung cancer and concurrence of pulmonary tuberculosis
  194. A rare case of endometrial polyp complicated with uterine inversion: A case report and clinical management
  195. Spontaneous rupturing of splenic artery aneurysm: Another reason for fatal syncope and shock (Case report and literature review)
  196. Fungal infection mimicking COVID-19 infection – A case report
  197. Concurrent aspergillosis and cystic pulmonary metastases in a patient with tongue squamous cell carcinoma
  198. Paraganglioma-induced inverted takotsubo-like cardiomyopathy leading to cardiogenic shock successfully treated with extracorporeal membrane oxygenation
  199. Lineage switch from lymphoma to myeloid neoplasms: First case series from a single institution
  200. Trismus during tracheal extubation as a complication of general anaesthesia – A case report
  201. Simultaneous treatment of a pubovesical fistula and lymph node metastasis secondary to multimodal treatment for prostate cancer: Case report and review of the literature
  202. Two case reports of skin vasculitis following the COVID-19 immunization
  203. Ureteroiliac fistula after oncological surgery: Case report and review of the literature
  204. Synchronous triple primary malignant tumours in the bladder, prostate, and lung harbouring TP53 and MEK1 mutations accompanied with severe cardiovascular diseases: A case report
  205. Huge mucinous cystic neoplasms with adhesion to the left colon: A case report and literature review
  206. Commentary
  207. Commentary on “Clinicopathological features of programmed cell death-ligand 1 expression in patients with oral squamous cell carcinoma”
  208. Rapid Communication
  209. COVID-19 fear, post-traumatic stress, growth, and the role of resilience
  210. Erratum
  211. Erratum to “Tollip promotes hepatocellular carcinoma progression via PI3K/AKT pathway”
  212. Erratum to “Effect of femoral head necrosis cystic area on femoral head collapse and stress distribution in femoral head: A clinical and finite element study”
  213. Erratum to “lncRNA NORAD promotes lung cancer progression by competitively binding to miR-28-3p with E2F2”
  214. Retraction
  215. Expression and role of ABIN1 in sepsis: In vitro and in vivo studies
  216. Retraction to “miR-519d downregulates LEP expression to inhibit preeclampsia development”
  217. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part II
  218. Usefulness of close surveillance for rectal cancer patients after neoadjuvant chemoradiotherapy
https://doi.org/10.1515/med-2022-0416
Schlagwörter für diesen Artikel
chronic obstructive pulmonary disease; quercitrin; oxidative stress; the Nrf2/HO-1/NQO1 pathway; the MAPK/ERK pathway
Creative Commons
BY 4.0

Artikel in diesem Heft

  1. Research Articles
  2. AMBRA1 attenuates the proliferation of uveal melanoma cells
  3. A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma
  4. Differences in complications between hepatitis B-related cirrhosis and alcohol-related cirrhosis
  5. Effect of gestational diabetes mellitus on lipid profile: A systematic review and meta-analysis
  6. Long noncoding RNA NR2F1-AS1 stimulates the tumorigenic behavior of non-small cell lung cancer cells by sponging miR-363-3p to increase SOX4
  7. Promising novel biomarkers and candidate small-molecule drugs for lung adenocarcinoma: Evidence from bioinformatics analysis of high-throughput data
  8. Plasmapheresis: Is it a potential alternative treatment for chronic urticaria?
  9. The biomarkers of key miRNAs and gene targets associated with extranodal NK/T-cell lymphoma
  10. Gene signature to predict prognostic survival of hepatocellular carcinoma
  11. Effects of miRNA-199a-5p on cell proliferation and apoptosis of uterine leiomyoma by targeting MED12
  12. Does diabetes affect paraneoplastic thrombocytosis in colorectal cancer?
  13. Is there any effect on imprinted genes H19, PEG3, and SNRPN during AOA?
  14. Leptin and PCSK9 concentrations are associated with vascular endothelial cytokines in patients with stable coronary heart disease
  15. Pericentric inversion of chromosome 6 and male fertility problems
  16. Staple line reinforcement with nebulized cyanoacrylate glue in laparoscopic sleeve gastrectomy: A propensity score-matched study
  17. Retrospective analysis of crescent score in clinical prognosis of IgA nephropathy
  18. Expression of DNM3 is associated with good outcome in colorectal cancer
  19. Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation
  20. CRRT influences PICCO measurements in febrile critically ill patients
  21. SLCO4A1-AS1 mediates pancreatic cancer development via miR-4673/KIF21B axis
  22. lncRNA ACTA2-AS1 inhibits malignant phenotypes of gastric cancer cells
  23. circ_AKT3 knockdown suppresses cisplatin resistance in gastric cancer
  24. Prognostic value of nicotinamide N-methyltransferase in human cancers: Evidence from a meta-analysis and database validation
  25. GPC2 deficiency inhibits cell growth and metastasis in colon adenocarcinoma
  26. A pan-cancer analysis of the oncogenic role of Holliday junction recognition protein in human tumors
  27. Radiation increases COL1A1, COL3A1, and COL1A2 expression in breast cancer
  28. Association between preventable risk factors and metabolic syndrome
  29. miR-29c-5p knockdown reduces inflammation and blood–brain barrier disruption by upregulating LRP6
  30. Cardiac contractility modulation ameliorates myocardial metabolic remodeling in a rabbit model of chronic heart failure through activation of AMPK and PPAR-α pathway
  31. Quercitrin protects human bronchial epithelial cells from oxidative damage
  32. Smurf2 suppresses the metastasis of hepatocellular carcinoma via ubiquitin degradation of Smad2
  33. circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury
  34. Sonoclot’s usefulness in prediction of cardiopulmonary arrest prognosis: A proof of concept study
  35. Four drug metabolism-related subgroups of pancreatic adenocarcinoma in prognosis, immune infiltration, and gene mutation
  36. Decreased expression of miR-195 mediated by hypermethylation promotes osteosarcoma
  37. LMO3 promotes proliferation and metastasis of papillary thyroid carcinoma cells by regulating LIMK1-mediated cofilin and the β-catenin pathway
  38. Cx43 upregulation in HUVECs under stretch via TGF-β1 and cytoskeletal network
  39. Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey
  40. Histopathologic findings on removed stomach after sleeve gastrectomy. Do they influence the outcome?
  41. Analysis of the expression and prognostic value of MT1-MMP, β1-integrin and YAP1 in glioma
  42. Optimal diagnosis of the skin cancer using a hybrid deep neural network and grasshopper optimization algorithm
  43. miR-223-3p alleviates TGF-β-induced epithelial-mesenchymal transition and extracellular matrix deposition by targeting SP3 in endometrial epithelial cells
  44. Clinical value of SIRT1 as a prognostic biomarker in esophageal squamous cell carcinoma, a systematic meta-analysis
  45. circ_0020123 promotes cell proliferation and migration in lung adenocarcinoma via PDZD8
  46. miR-22-5p regulates the self-renewal of spermatogonial stem cells by targeting EZH2
  47. hsa-miR-340-5p inhibits epithelial–mesenchymal transition in endometriosis by targeting MAP3K2 and inactivating MAPK/ERK signaling
  48. circ_0085296 inhibits the biological functions of trophoblast cells to promote the progression of preeclampsia via the miR-942-5p/THBS2 network
  49. TCD hemodynamics findings in the subacute phase of anterior circulation stroke patients treated with mechanical thrombectomy
  50. Development of a risk-stratification scoring system for predicting risk of breast cancer based on non-alcoholic fatty liver disease, non-alcoholic fatty pancreas disease, and uric acid
  51. Tollip promotes hepatocellular carcinoma progression via PI3K/AKT pathway
  52. circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis
  53. Human amniotic fluid as a source of stem cells
  54. lncRNA NONRATT013819.2 promotes transforming growth factor-β1-induced myofibroblastic transition of hepatic stellate cells by miR24-3p/lox
  55. NORAD modulates miR-30c-5p-LDHA to protect lung endothelial cells damage
  56. Idiopathic pulmonary fibrosis telemedicine management during COVID-19 outbreak
  57. Risk factors for adverse drug reactions associated with clopidogrel therapy
  58. Serum zinc associated with immunity and inflammatory markers in Covid-19
  59. The relationship between night shift work and breast cancer incidence: A systematic review and meta-analysis of observational studies
  60. LncRNA expression in idiopathic achalasia: New insight and preliminary exploration into pathogenesis
  61. Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway
  62. Moscatilin suppresses the inflammation from macrophages and T cells
  63. Zoledronate promotes ECM degradation and apoptosis via Wnt/β-catenin
  64. Epithelial-mesenchymal transition-related genes in coronary artery disease
  65. The effect evaluation of traditional vaginal surgery and transvaginal mesh surgery for severe pelvic organ prolapse: 5 years follow-up
  66. Repeated partial splenic artery embolization for hypersplenism improves platelet count
  67. Low expression of miR-27b in serum exosomes of non-small cell lung cancer facilitates its progression by affecting EGFR
  68. Exosomal hsa_circ_0000519 modulates the NSCLC cell growth and metastasis via miR-1258/RHOV axis
  69. miR-455-5p enhances 5-fluorouracil sensitivity in colorectal cancer cells by targeting PIK3R1 and DEPDC1
  70. The effect of tranexamic acid on the reduction of intraoperative and postoperative blood loss and thromboembolic risk in patients with hip fracture
  71. Isocitrate dehydrogenase 1 mutation in cholangiocarcinoma impairs tumor progression by sensitizing cells to ferroptosis
  72. Artemisinin protects against cerebral ischemia and reperfusion injury via inhibiting the NF-κB pathway
  73. A 16-gene signature associated with homologous recombination deficiency for prognosis prediction in patients with triple-negative breast cancer
  74. Lidocaine ameliorates chronic constriction injury-induced neuropathic pain through regulating M1/M2 microglia polarization
  75. MicroRNA 322-5p reduced neuronal inflammation via the TLR4/TRAF6/NF-κB axis in a rat epilepsy model
  76. miR-1273h-5p suppresses CXCL12 expression and inhibits gastric cancer cell invasion and metastasis
  77. Clinical characteristics of pneumonia patients of long course of illness infected with SARS-CoV-2
  78. circRNF20 aggravates the malignancy of retinoblastoma depending on the regulation of miR-132-3p/PAX6 axis
  79. Linezolid for resistant Gram-positive bacterial infections in children under 12 years: A meta-analysis
  80. Rack1 regulates pro-inflammatory cytokines by NF-κB in diabetic nephropathy
  81. Comprehensive analysis of molecular mechanism and a novel prognostic signature based on small nuclear RNA biomarkers in gastric cancer patients
  82. Smog and risk of maternal and fetal birth outcomes: A retrospective study in Baoding, China
  83. Let-7i-3p inhibits the cell cycle, proliferation, invasion, and migration of colorectal cancer cells via downregulating CCND1
  84. β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis
  85. Possible impact of COVID-19 pandemic and lockdown on suicide behavior among patients in Southeast Serbia
  86. In vitro antimicrobial activity of ozonated oil in liposome eyedrop against multidrug-resistant bacteria
  87. Potential biomarkers for inflammatory response in acute lung injury
  88. A low serum uric acid concentration predicts a poor prognosis in adult patients with candidemia
  89. Antitumor activity of recombinant oncolytic vaccinia virus with human IL2
  90. ALKBH5 inhibits TNF-α-induced apoptosis of HUVECs through Bcl-2 pathway
  91. Risk prediction of cardiovascular disease using machine learning classifiers
  92. Value of ultrasonography parameters in diagnosing polycystic ovary syndrome
  93. Bioinformatics analysis reveals three key genes and four survival genes associated with youth-onset NSCLC
  94. Identification of autophagy-related biomarkers in patients with pulmonary arterial hypertension based on bioinformatics analysis
  95. Protective effects of glaucocalyxin A on the airway of asthmatic mice
  96. Overexpression of miR-100-5p inhibits papillary thyroid cancer progression via targeting FZD8
  97. Bioinformatics-based analysis of SUMOylation-related genes in hepatocellular carcinoma reveals a role of upregulated SAE1 in promoting cell proliferation
  98. Effectiveness and clinical benefits of new anti-diabetic drugs: A real life experience
  99. Identification of osteoporosis based on gene biomarkers using support vector machine
  100. Tanshinone IIA reverses oxaliplatin resistance in colorectal cancer through microRNA-30b-5p/AVEN axis
  101. miR-212-5p inhibits nasopharyngeal carcinoma progression by targeting METTL3
  102. Association of ST-T changes with all-cause mortality among patients with peripheral T-cell lymphomas
  103. LINC00665/miRNAs axis-mediated collagen type XI alpha 1 correlates with immune infiltration and malignant phenotypes in lung adenocarcinoma
  104. The perinatal factors that influence the excretion of fecal calprotectin in premature-born children
  105. Effect of femoral head necrosis cystic area on femoral head collapse and stress distribution in femoral head: A clinical and finite element study
  106. Does the use of 3D-printed cones give a chance to postpone the use of megaprostheses in patients with large bone defects in the knee joint?
  107. lncRNA HAGLR modulates myocardial ischemia–reperfusion injury in mice through regulating miR-133a-3p/MAPK1 axis
  108. Protective effect of ghrelin on intestinal I/R injury in rats
  109. In vivo knee kinematics of an innovative prosthesis design
  110. Relationship between the height of fibular head and the incidence and severity of knee osteoarthritis
  111. lncRNA WT1-AS attenuates hypoxia/ischemia-induced neuronal injury during cerebral ischemic stroke via miR-186-5p/XIAP axis
  112. Correlation of cardiac troponin T and APACHE III score with all-cause in-hospital mortality in critically ill patients with acute pulmonary embolism
  113. LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axis
  114. Endothelial cell-specific molecule 1 (ESM1) promoted by transcription factor SPI1 acts as an oncogene to modulate the malignant phenotype of endometrial cancer
  115. SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial–mesenchymal transition
  116. Visfatin is negatively associated with coronary artery lesions in subjects with impaired fasting glucose
  117. Treatment and outcomes of mechanical complications of acute myocardial infarction during the Covid-19 era: A comparison with the pre-Covid-19 period. A systematic review and meta-analysis
  118. Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland
  119. Oncogenic role of TWF2 in human tumors: A pan-cancer analysis
  120. Mean corpuscular hemoglobin predicts the length of hospital stay independent of severity classification in patients with acute pancreatitis
  121. Association of gallstone and polymorphisms of UGT1A1*27 and UGT1A1*28 in patients with hepatitis B virus-related liver failure
  122. TGF-β1 upregulates Sar1a expression and induces procollagen-I secretion in hypertrophic scarring fibroblasts
  123. Antisense lncRNA PCNA-AS1 promotes esophageal squamous cell carcinoma progression through the miR-2467-3p/PCNA axis
  124. NK-cell dysfunction of acute myeloid leukemia in relation to the renin–angiotensin system and neurotransmitter genes
  125. The effect of dilution with glucose and prolonged injection time on dexamethasone-induced perineal irritation – A randomized controlled trial
  126. miR-146-5p restrains calcification of vascular smooth muscle cells by suppressing TRAF6
  127. Role of lncRNA MIAT/miR-361-3p/CCAR2 in prostate cancer cells
  128. lncRNA NORAD promotes lung cancer progression by competitively binding to miR-28-3p with E2F2
  129. Noninvasive diagnosis of AIH/PBC overlap syndrome based on prediction models
  130. lncRNA FAM230B is highly expressed in colorectal cancer and suppresses the maturation of miR-1182 to increase cell proliferation
  131. circ-LIMK1 regulates cisplatin resistance in lung adenocarcinoma by targeting miR-512-5p/HMGA1 axis
  132. LncRNA SNHG3 promoted cell proliferation, migration, and metastasis of esophageal squamous cell carcinoma via regulating miR-151a-3p/PFN2 axis
  133. Risk perception and affective state on work exhaustion in obstetrics during the COVID-19 pandemic
  134. lncRNA-AC130710/miR-129-5p/mGluR1 axis promote migration and invasion by activating PKCα-MAPK signal pathway in melanoma
  135. SNRPB promotes cell cycle progression in thyroid carcinoma via inhibiting p53
  136. Xylooligosaccharides and aerobic training regulate metabolism and behavior in rats with streptozotocin-induced type 1 diabetes
  137. Serpin family A member 1 is an oncogene in glioma and its translation is enhanced by NAD(P)H quinone dehydrogenase 1 through RNA-binding activity
  138. Silencing of CPSF7 inhibits the proliferation, migration, and invasion of lung adenocarcinoma cells by blocking the AKT/mTOR signaling pathway
  139. Ultrasound-guided lumbar plexus block versus transversus abdominis plane block for analgesia in children with hip dislocation: A double-blind, randomized trial
  140. Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm
  141. Identification of a novel necroptosis-associated miRNA signature for predicting the prognosis in head and neck squamous cell carcinoma
  142. Delayed femoral vein ligation reduces operative time and blood loss during hip disarticulation in patients with extremity tumors
  143. The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients
  144. Longitudinal analysis of factors related to Helicobacter pylori infection in Chinese adults
  145. HOXA10 enhances cell proliferation and suppresses apoptosis in esophageal cancer via activating p38/ERK signaling pathway
  146. Meta-analysis of early-life antibiotic use and allergic rhinitis
  147. Marital status and its correlation with age, race, and gender in prognosis of tonsil squamous cell carcinomas
  148. HPV16 E6E7 up-regulates KIF2A expression by activating JNK/c-Jun signal, is beneficial to migration and invasion of cervical cancer cells
  149. Amino acid profiles in the tissue and serum of patients with liver cancer
  150. Pain in critically ill COVID-19 patients: An Italian retrospective study
  151. Immunohistochemical distribution of Bcl-2 and p53 apoptotic markers in acetamiprid-induced nephrotoxicity
  152. Estradiol pretreatment in GnRH antagonist protocol for IVF/ICSI treatment
  153. Long non-coding RNAs LINC00689 inhibits the apoptosis of human nucleus pulposus cells via miR-3127-5p/ATG7 axis-mediated autophagy
  154. The relationship between oxygen therapy, drug therapy, and COVID-19 mortality
  155. Monitoring hypertensive disorders in pregnancy to prevent preeclampsia in pregnant women of advanced maternal age: Trial mimicking with retrospective data
  156. SETD1A promotes the proliferation and glycolysis of nasopharyngeal carcinoma cells by activating the PI3K/Akt pathway
  157. The role of Shunaoxin pills in the treatment of chronic cerebral hypoperfusion and its main pharmacodynamic components
  158. TET3 governs malignant behaviors and unfavorable prognosis of esophageal squamous cell carcinoma by activating the PI3K/AKT/GSK3β/β-catenin pathway
  159. Associations between morphokinetic parameters of temporary-arrest embryos and the clinical prognosis in FET cycles
  160. Long noncoding RNA WT1-AS regulates trophoblast proliferation, migration, and invasion via the microRNA-186-5p/CADM2 axis
  161. The incidence of bronchiectasis in chronic obstructive pulmonary disease
  162. Integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancer
  163. Inhibition of miR-21 improves pulmonary vascular responses in bronchopulmonary dysplasia by targeting the DDAH1/ADMA/NO pathway
  164. Comparison of hospitalized patients with severe pneumonia caused by COVID-19 and influenza A (H7N9 and H1N1): A retrospective study from a designated hospital
  165. lncRNA ZFAS1 promotes intervertebral disc degeneration by upregulating AAK1
  166. Pathological characteristics of liver injury induced by N,N-dimethylformamide: From humans to animal models
  167. lncRNA ELFN1-AS1 enhances the progression of colon cancer by targeting miR-4270 to upregulate AURKB
  168. DARS-AS1 modulates cell proliferation and migration of gastric cancer cells by regulating miR-330-3p/NAT10 axis
  169. Dezocine inhibits cell proliferation, migration, and invasion by targeting CRABP2 in ovarian cancer
  170. MGST1 alleviates the oxidative stress of trophoblast cells induced by hypoxia/reoxygenation and promotes cell proliferation, migration, and invasion by activating the PI3K/AKT/mTOR pathway
  171. Bifidobacterium lactis Probio-M8 ameliorated the symptoms of type 2 diabetes mellitus mice by changing ileum FXR-CYP7A1
  172. circRNA DENND1B inhibits tumorigenicity of clear cell renal cell carcinoma via miR-122-5p/TIMP2 axis
  173. EphA3 targeted by miR-3666 contributes to melanoma malignancy via activating ERK1/2 and p38 MAPK pathways
  174. Pacemakers and methylprednisolone pulse therapy in immune-related myocarditis concomitant with complete heart block
  175. miRNA-130a-3p targets sphingosine-1-phosphate receptor 1 to activate the microglial and astrocytes and to promote neural injury under the high glucose condition
  176. Review Articles
  177. Current management of cancer pain in Italy: Expert opinion paper
  178. Hearing loss and brain disorders: A review of multiple pathologies
  179. The rationale for using low-molecular weight heparin in the therapy of symptomatic COVID-19 patients
  180. Amyotrophic lateral sclerosis and delayed onset muscle soreness in light of the impaired blink and stretch reflexes – watch out for Piezo2
  181. Interleukin-35 in autoimmune dermatoses: Current concepts
  182. Recent discoveries in microbiota dysbiosis, cholangiocytic factors, and models for studying the pathogenesis of primary sclerosing cholangitis
  183. Advantages of ketamine in pediatric anesthesia
  184. Congenital adrenal hyperplasia. Role of dentist in early diagnosis
  185. Migraine management: Non-pharmacological points for patients and health care professionals
  186. Atherogenic index of plasma and coronary artery disease: A systematic review
  187. Physiological and modulatory role of thioredoxins in the cellular function
  188. Case Reports
  189. Intrauterine Bakri balloon tamponade plus cervical cerclage for the prevention and treatment of postpartum haemorrhage in late pregnancy complicated with acute aortic dissection: Case series
  190. A case of successful pembrolizumab monotherapy in a patient with advanced lung adenocarcinoma: Use of multiple biomarkers in combination for clinical practice
  191. Unusual neurological manifestations of bilateral medial medullary infarction: A case report
  192. Atypical symptoms of malignant hyperthermia: A rare causative mutation in the RYR1 gene
  193. A case report of dermatomyositis with the missed diagnosis of non-small cell lung cancer and concurrence of pulmonary tuberculosis
  194. A rare case of endometrial polyp complicated with uterine inversion: A case report and clinical management
  195. Spontaneous rupturing of splenic artery aneurysm: Another reason for fatal syncope and shock (Case report and literature review)
  196. Fungal infection mimicking COVID-19 infection – A case report
  197. Concurrent aspergillosis and cystic pulmonary metastases in a patient with tongue squamous cell carcinoma
  198. Paraganglioma-induced inverted takotsubo-like cardiomyopathy leading to cardiogenic shock successfully treated with extracorporeal membrane oxygenation
  199. Lineage switch from lymphoma to myeloid neoplasms: First case series from a single institution
  200. Trismus during tracheal extubation as a complication of general anaesthesia – A case report
  201. Simultaneous treatment of a pubovesical fistula and lymph node metastasis secondary to multimodal treatment for prostate cancer: Case report and review of the literature
  202. Two case reports of skin vasculitis following the COVID-19 immunization
  203. Ureteroiliac fistula after oncological surgery: Case report and review of the literature
  204. Synchronous triple primary malignant tumours in the bladder, prostate, and lung harbouring TP53 and MEK1 mutations accompanied with severe cardiovascular diseases: A case report
  205. Huge mucinous cystic neoplasms with adhesion to the left colon: A case report and literature review
  206. Commentary
  207. Commentary on “Clinicopathological features of programmed cell death-ligand 1 expression in patients with oral squamous cell carcinoma”
  208. Rapid Communication
  209. COVID-19 fear, post-traumatic stress, growth, and the role of resilience
  210. Erratum
  211. Erratum to “Tollip promotes hepatocellular carcinoma progression via PI3K/AKT pathway”
  212. Erratum to “Effect of femoral head necrosis cystic area on femoral head collapse and stress distribution in femoral head: A clinical and finite element study”
  213. Erratum to “lncRNA NORAD promotes lung cancer progression by competitively binding to miR-28-3p with E2F2”
  214. Retraction
  215. Expression and role of ABIN1 in sepsis: In vitro and in vivo studies
  216. Retraction to “miR-519d downregulates LEP expression to inhibit preeclampsia development”
  217. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part II
  218. Usefulness of close surveillance for rectal cancer patients after neoadjuvant chemoradiotherapy
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Heruntergeladen am 11.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/med-2022-0416/html
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