Abstract
The issue of surgical site infections has become more critical during the last years. The number of airborne microbes depends on the number released by the staff in the room or supplied from neighbouring rooms. In order to minimize the risk of nosocomial infections during surgical procedures technical developments like ventilation systems were introduced in the operating room (OR). In this study several factors like clothing and types of ventilation systems have been investigated and their impact on the effectiveness for reducing microbial burden in the OR has been assessed. In case of OR-gowns we found a benefit for a disposable Swedish clothing concept regarding microbiological contamination in comparison with the German standard multiuse clothing. Moreover our study shows that there is comparable effectiveness of a fairly novel temperature controlled airflow ventilation system (TAF) compared to standard low turbulent uni-directional airflow (TAV).
1 Introduction
According to studies, surgical site infections are the most common nosocomial infections. [1] The German DIN 1946/4 (2008) demands a low turbulent uni-directional airflow system (TAV) for a class Ia OR used for infection sensitive surgeries [2]. In a room class Ia generally operations with a large wound area take place, e.g. open surgical procedures such as joint replacements. In contrast to this standard system a new temperature controlled airflow ventilation system (Opragon) was developed by the Swedish company Avidicare AB [3]. Opragon supplies the operative zone with slightly cooled, HEPA-filtered air (class H14) from an external air treatment unit equipped with a heating/cooling battery. The supply air is discharged through hemispherical air showers (air volume per shower = approx. 350 m3/h) and falls to the floor, where it is sucked into the side corners. It is crucial that the temperature of the air above the operative zone is cooler than the outer room air in the operating room. The higher density of the cooled air causes it to fall at a speed dictated by this temperature difference. This System was set up in the research OR at the Ostbayerische Technische Hochschule in Weiden for further studies.
The condition of OR clothing is also determined in a German directive, the DIN EN 13795 [4]. This clothing is necessary for the stability of hygiene in the OR and has to protect the medical staff and the patient from microbiological contaminations and infections. In contrast to the German OR scrubs, the Swedish single-use design has obvious differences like tightened cuffs or a closed neck region to avoid unintentional spreading of particles (Figure 1).

Comparison of German and Swedish OR clothing.
2 Material and methods
To examine the impact on the microbiological burden in the OR we performed active air samplings on culture plates (blood agar plates; BD). The samplings were done for 1 h with an interval of six plates for 10 min each. The overall volume was 1 m3 for each sampling. During the measurement a simulated surgical procedure was performed with seven participants according to the Swedish standard for ventilation systems in the OR SIS-TS 39:2012 [5]. Three locations in the OR were defined as measuring points: the OR table, the instrument table and the peripheral region of the OR near to an air exhaust. The plates were incubated for 72 h at 35 ± 1°C. After incubation the colonies were counted and documented as colony forming units/m3 (CFU/m3).
These measurements were repeated up to 144 times to determine the differences between the Swedish and the German OR clothing and also in three ORs with different ventilation systems.
3 Results
In case of the OR clothing a reduction of the microbial burden could be detected in our experiments by the use of the Swedish in contrast to the German gowns (Table 1).
Comparison of the differences in the microbiological burden in the OR with Swedish and German OR clothing.
| Location | German clothing (CFU/m3) | Swedish clothing (CFU/m3) |
|---|---|---|
| OR table | ||
| max. value | 9 | 1 |
| mean value | 2,5 | 0,3 |
| Instrument board | ||
| max. value | 13 | 2 |
| mean value | 3,67 | 0,42 |
| Periphery | ||
| max. value | 51 | 12 |
| mean value | 27,67 | 6,25 |
During the whole experiment a germ reduction of approx. 3–10 fold could be measured for the Swedish clothing compared with the German clothing.
Our benchmark studies for the different ventilation systems were done in the research OR at the University in Weiden for the temperature controlled ventilation (TAF), as well as in a class Ia OR TAV and a class Ib OR turbulent mixed ventilation (TML) in a collaborating hospital. The measurements were also performed according to the Swedish SIS-TS 39:2012 to obtain comparable results for the different ventilation systems. Again the same three locations were defined as measuring points: the OR table, the instrument board and the peripheral region of the OR near to an air exhaust. As a result the TAF ventilation system reaches similar if not better results than the standard low turbulent uni-directional airflow system for German class Ia OR. The class Ib OR with the TML showed the expected higher CFU counts for the bacterial burden (Table 2). Because of a minor difference and the generally very small values directly under the ventilation system (OR table) the measurements from all three locations (OR Table, Instrument board and Periphery) were combined to one mean value for a better clarity and comparability.
Comparison of the different ventilation systems for bacterial burden in the air as a mean value over all measurement points (n = 144 for TAF and n = 72 for TAV and TML).
| Ventilation system | Max. value (CFU/m3) | Overall mean value (CFU/m3) |
|---|---|---|
| TAF | 51 | 5 |
| TAV | 62 | 10 |
| TML | 154 | 38 |
4 Conclusion
Although no statistical Tests were performed due to the relatively small amount of measurements, our results indicate an at least similar efficiency of the new developed temperature based ventilation system compared with the hitherto standardly used TAV system for a class Ia OR. It should be discussed if the technologies should be treated equally.
Also we could show an influence of the OR clothing on the bacterial burden in the OR. Here the Swedish clothing concept is more favourable than the German. It should be discussed, if the advantage in hygiene is worth the probably higher costs for the single-use strategy.
These trends will be investigated further with a broader set of experiments to achieve a statistically assessable amount of Data.
Acknowledgement
The authors want to thank Peter Ekolind for his support with the Swedish documents and material.
Author’s Statement
Research funding: The author state no funding involved. Conflict of interest: Authors state no conflict of interest. Material and methods: Informed consent: Informed consent is not applicable. Ethical approval: The conducted research is not related to either human or animals use.
References
[1] Behnke M, Hansen S, Leistner R, Diaz LA, Gropmann A, Sohr D, et al. Nosocomial infection and antibiotic use: a second national prevalence study in Germany. Dtsch Arztebl Int. 2013;110:627–33.10.3238/arztebl.2013.0627Search in Google Scholar PubMed PubMed Central
[2] DIN 1946 Dezember 2008: Raumlufttechnik – Teil 4: Raumlufttechnische Anlagen in Gebäuden und Räumen des Gesundheitswesens 2008.Search in Google Scholar
[3] www.avidicare.deSearch in Google Scholar
[4] DIN EN 13795 Oktober 2013: OP-Abdecktücher, -mäntel und Rein-Luft-Kleidung zur Verwendung als Medizinprodukte für Patienten, Klinikpersonal und Geräte- Allgemeine Anforderungen für Hersteller, Wiederaufbereiter und Produkte, Prüfverfahren und Gebrauchsanforderungen; Deutsche Fassung EN 13795:2011 + A1:2013. Berlin: Beuth Verlag GmbH.Search in Google Scholar
©2016 Clemens Bulitta et al., licensee De Gruyter.
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
Articles in the same Issue
- Synthesis and characterization of PIL/pNIPAAm hybrid hydrogels
- Novel blood protein based scaffolds for cardiovascular tissue engineering
- Cell adhesion and viability of human endothelial cells on electrospun polymer scaffolds
- Effects of heat treatment and welding process on superelastic behaviour and microstructure of micro electron beam welded NiTi
- Long-term stable modifications of silicone elastomer for improved hemocompatibility
- The effect of thermal treatment on the mechanical properties of PLLA tubular specimens
- Biocompatible wear-resistant thick ceramic coating
- Protection of active implant electronics with organosilicon open air plasma coating for plastic overmolding
- Examination of dielectric strength of thin Parylene C films under various conditions
- Open air plasma deposited antimicrobial SiOx/TiOx composite films for biomedical applications
- Systemic analysis about residual chloroform in PLLA films
- A macrophage model of osseointegration
- Towards in silico prognosis using big data
- Technical concept and evaluation of a novel shoulder simulator with adaptive muscle force generation and free motion
- Usability evaluation of a locomotor therapy device considering different strategies
- Hypoxia-on-a-chip
- Integration of a semi-automatic in-vitro RFA procedure into an experimental setup
- Fabrication of MEMS-based 3D-μECoG-MEAs
- High speed digital interfacing for a neural data acquisition system
- Bionic forceps for the handling of sensitive tissue
- Experimental studies on 3D printing of barium titanate ceramics for medical applications
- Patient specific root-analogue dental implants – additive manufacturing and finite element analysis
- 3D printing – a key technology for tailored biomedical cell culture lab ware
- 3D printing of hydrogels in a temperature controlled environment with high spatial resolution
- Biocompatibility of photopolymers for additive manufacturing
- Biochemical piezoresistive sensors based on pH- and glucose-sensitive hydrogels for medical applications
- Novel wireless measurement system of pressure dedicated to in vivo studies
- Portable auricular device for real-time swallow and chew detection
- Detection of miRNA using a surface plasmon resonance biosensor and antibody amplification
- Simulation and evaluation of stimulation scenarios for targeted vestibular nerve excitation
- Deep brain stimulation: increasing efficiency by alternative waveforms
- Prediction of immediately occurring microsleep events from brain electric signals
- Determining cardiac vagal threshold from short term heart rate complexity
- Classification of cardiac excitation patterns during atrial fibrillation
- An algorithm to automatically determine the cycle length coverage to identify rotational activity during atrial fibrillation – a simulation study
- Deriving respiration from high resolution 12-channel-ECG during cycling exercise
- Reducing of gradient induced artifacts on the ECG signal during MRI examinations using Wilcoxon filter
- Automatic detection and mapping of double potentials in intracardiac electrograms
- Modeling the pelvic region for non-invasive pelvic intraoperative neuromonitoring
- Postprocessing algorithm for automated analysis of pelvic intraoperative neuromonitoring signals
- Best practice: surgeon driven application in pelvic operations
- Vasomotor assessment by camera-based photoplethysmography
- Classification of morphologic changes in photoplethysmographic waveforms
- Novel computation of pulse transit time from multi-channel PPG signals by wavelet transform
- Efficient design of FIR filter based low-pass differentiators for biomedical signal processing
- Nonlinear causal influences assessed by mutual compression entropy
- Comparative study of methods for solving the correspondence problem in EMD applications
- fNIRS for future use in auditory diagnostics
- Semi-automated detection of fractional shortening in zebrafish embryo heart videos
- Blood pressure measurement on the cheek
- Derivation of the respiratory rate from directly and indirectly measured respiratory signals using autocorrelation
- Left cardiac atrioventricular delay and inter-ventricular delay in cardiac resynchronization therapy responder and non-responder
- An automatic systolic peak detector of blood pressure waveforms using 4th order cumulants
- Real-time QRS detection using integrated variance for ECG gated cardiac MRI
- Preprocessing of unipolar signals acquired by a novel intracardiac mapping system
- In-vitro experiments to characterize ventricular electromechanics
- Continuous non-invasive monitoring of blood pressure in the operating room: a cuffless optical technology at the fingertip
- Application of microwave sensor technology in cardiovascular disease for plaque detection
- Artificial blood circulatory and special Ultrasound Doppler probes for detecting and sizing gaseous embolism
- Detection of microsleep events in a car driving simulation study using electrocardiographic features
- A method to determine the kink resistance of stents and stent delivery systems according to international standards
- Comparison of stented bifurcation and straight vessel 3D-simulation with a prior simulated velocity profile inlet
- Transient Euler-Lagrange/DEM simulation of stent thrombosis
- Automated control of the laser welding process of heart valve scaffolds
- Automation of a test bench for accessing the bendability of electrospun vascular grafts
- Influence of storage conditions on the release of growth factors in platelet-rich blood derivatives
- Cryopreservation of cells using defined serum-free cryoprotective agents
- New bioreactor vessel for tissue engineering of human nasal septal chondrocytes
- Determination of the membrane hydraulic permeability of MSCs
- Climate retainment in carbon dioxide incubators
- Multiple factors influencing OR ventilation system effectiveness
- Evaluation of an app-based stress protocol
- Medication process in Styrian hospitals
- Control tower to surgical theater
- Development of a skull phantom for the assessment of implant X-ray visibility
- Surgical navigation with QR codes
- Investigation of the pressure gradient of embolic protection devices
- Computer assistance in femoral derotation osteotomy: a bottom-up approach
- Automatic depth scanning system for 3D infrared thermography
- A service for monitoring the quality of intraoperative cone beam CT images
- Resectoscope with an easy to use twist mechanism for improved handling
- In vitro simulation of distribution processes following intramuscular injection
- Adjusting inkjet printhead parameters to deposit drugs into micro-sized reservoirs
- A flexible standalone system with integrated sensor feedback for multi-pad electrode FES of the hand
- Smart control for functional electrical stimulation with optimal pulse intensity
- Tactile display on the remaining hand for unilateral hand amputees
- Effects of sustained electrical stimulation on spasticity assessed by the pendulum test
- An improved tracking framework for ultrasound probe localization in image-guided radiosurgery
- Improvement of a subviral particle tracker by the use of a LAP-Kalman-algorithm
- Learning discriminative classification models for grading anal intraepithelial neoplasia
- Regularization of EIT reconstruction based on multi-scales wavelet transforms
- Assessing MRI susceptibility artefact through an indicator of image distortion
- EyeGuidance – a computer controlled system to guide eye movements
- A framework for feedback-based segmentation of 3D image stacks
- Doppler optical coherence tomography as a promising tool for detecting fluid in the human middle ear
- 3D Local in vivo Environment (LivE) imaging for single cell protein analysis of bone tissue
- Inside-Out access strategy using new trans-vascular catheter approach
- US/MRI fusion with new optical tracking and marker approach for interventional procedures inside the MRI suite
- Impact of different registration methods in MEG source analysis
- 3D segmentation of thyroid ultrasound images using active contours
- Designing a compact MRI motion phantom
- Cerebral cortex classification by conditional random fields applied to intraoperative thermal imaging
- Classification of indirect immunofluorescence images using thresholded local binary count features
- Analysis of muscle fatigue conditions using time-frequency images and GLCM features
- Numerical evaluation of image parameters of ETR-1
- Fabrication of a compliant phantom of the human aortic arch for use in Particle Image Velocimetry (PIV) experimentation
- Effect of the number of electrodes on the reconstructed lung shape in electrical impedance tomography
- Hardware dependencies of GPU-accelerated beamformer performances for microwave breast cancer detection
- Computer assisted assessment of progressing osteoradionecrosis of the jaw for clinical diagnosis and treatment
- Evaluation of reconstruction parameters of electrical impedance tomography on aorta detection during saline bolus injection
- Evaluation of open-source software for the lung segmentation
- Automatic determination of lung features of CF patients in CT scans
- Image analysis of self-organized multicellular patterns
- Effect of key parameters on synthesis of superparamagnetic nanoparticles (SPIONs)
- Radiopacity assessment of neurovascular implants
- Development of a desiccant based dielectric for monitoring humidity conditions in miniaturized hermetic implantable packages
- Development of an artifact-free aneurysm clip
- Enhancing the regeneration of bone defects by alkalizing the peri-implant zone – an in vitro approach
- Rapid prototyping of replica knee implants for in vitro testing
- Protecting ultra- and hyperhydrophilic implant surfaces in dry state from loss of wettability
- Advanced wettability analysis of implant surfaces
- Patient-specific hip prostheses designed by surgeons
- Plasma treatment on novel carbon fiber reinforced PEEK cages to enhance bioactivity
- Wear of a total intervertebral disc prosthesis
- Digital health and digital biomarkers – enabling value chains on health data
- Usability in the lifecycle of medical software development
- Influence of different test gases in a non-destructive 100% quality control system for medical devices
- Device development guided by user satisfaction survey on auricular vagus nerve stimulation
- Empirical assessment of the time course of innovation in biomedical engineering: first results of a comparative approach
- Effect of left atrial hypertrophy on P-wave morphology in a computational model
- Simulation of intracardiac electrograms around acute ablation lesions
- Parametrization of activation based cardiac electrophysiology models using bidomain model simulations
- Assessment of nasal resistance using computational fluid dynamics
- Resistance in a non-linear autoregressive model of pulmonary mechanics
- Inspiratory and expiratory elastance in a non-linear autoregressive model of pulmonary mechanics
- Determination of regional lung function in cystic fibrosis using electrical impedance tomography
- Development of parietal bone surrogates for parietal graft lift training
- Numerical simulation of mechanically stimulated bone remodelling
- Conversion of engineering stresses to Cauchy stresses in tensile and compression tests of thermoplastic polymers
- Numerical examinations of simplified spondylodesis models concerning energy absorption in magnetic resonance imaging
- Principle study on the signal connection at transabdominal fetal pulse oximetry
- Influence of Siluron® insertion on model drug distribution in the simulated vitreous body
- Evaluating different approaches to identify a three parameter gas exchange model
- Effects of fibrosis on the extracellular potential based on 3D reconstructions from histological sections of heart tissue
- From imaging to hemodynamics – how reconstruction kernels influence the blood flow predictions in intracranial aneurysms
- Flow optimised design of a novel point-of-care diagnostic device for the detection of disease specific biomarkers
- Improved FPGA controlled artificial vascular system for plethysmographic measurements
- Minimally spaced electrode positions for multi-functional chest sensors: ECG and respiratory signal estimation
- Automated detection of alveolar arches for nasoalveolar molding in cleft lip and palate treatment
- Control scheme selection in human-machine- interfaces by analysis of activity signals
- Event-based sampling for reducing communication load in realtime human motion analysis by wireless inertial sensor networks
- Automatic pairing of inertial sensors to lower limb segments – a plug-and-play approach
- Contactless respiratory monitoring system for magnetic resonance imaging applications using a laser range sensor
- Interactive monitoring system for visual respiratory biofeedback
- Development of a low-cost senor based aid for visually impaired people
- Patient assistive system for the shoulder joint
- A passive beating heart setup for interventional cardiology training
Articles in the same Issue
- Synthesis and characterization of PIL/pNIPAAm hybrid hydrogels
- Novel blood protein based scaffolds for cardiovascular tissue engineering
- Cell adhesion and viability of human endothelial cells on electrospun polymer scaffolds
- Effects of heat treatment and welding process on superelastic behaviour and microstructure of micro electron beam welded NiTi
- Long-term stable modifications of silicone elastomer for improved hemocompatibility
- The effect of thermal treatment on the mechanical properties of PLLA tubular specimens
- Biocompatible wear-resistant thick ceramic coating
- Protection of active implant electronics with organosilicon open air plasma coating for plastic overmolding
- Examination of dielectric strength of thin Parylene C films under various conditions
- Open air plasma deposited antimicrobial SiOx/TiOx composite films for biomedical applications
- Systemic analysis about residual chloroform in PLLA films
- A macrophage model of osseointegration
- Towards in silico prognosis using big data
- Technical concept and evaluation of a novel shoulder simulator with adaptive muscle force generation and free motion
- Usability evaluation of a locomotor therapy device considering different strategies
- Hypoxia-on-a-chip
- Integration of a semi-automatic in-vitro RFA procedure into an experimental setup
- Fabrication of MEMS-based 3D-μECoG-MEAs
- High speed digital interfacing for a neural data acquisition system
- Bionic forceps for the handling of sensitive tissue
- Experimental studies on 3D printing of barium titanate ceramics for medical applications
- Patient specific root-analogue dental implants – additive manufacturing and finite element analysis
- 3D printing – a key technology for tailored biomedical cell culture lab ware
- 3D printing of hydrogels in a temperature controlled environment with high spatial resolution
- Biocompatibility of photopolymers for additive manufacturing
- Biochemical piezoresistive sensors based on pH- and glucose-sensitive hydrogels for medical applications
- Novel wireless measurement system of pressure dedicated to in vivo studies
- Portable auricular device for real-time swallow and chew detection
- Detection of miRNA using a surface plasmon resonance biosensor and antibody amplification
- Simulation and evaluation of stimulation scenarios for targeted vestibular nerve excitation
- Deep brain stimulation: increasing efficiency by alternative waveforms
- Prediction of immediately occurring microsleep events from brain electric signals
- Determining cardiac vagal threshold from short term heart rate complexity
- Classification of cardiac excitation patterns during atrial fibrillation
- An algorithm to automatically determine the cycle length coverage to identify rotational activity during atrial fibrillation – a simulation study
- Deriving respiration from high resolution 12-channel-ECG during cycling exercise
- Reducing of gradient induced artifacts on the ECG signal during MRI examinations using Wilcoxon filter
- Automatic detection and mapping of double potentials in intracardiac electrograms
- Modeling the pelvic region for non-invasive pelvic intraoperative neuromonitoring
- Postprocessing algorithm for automated analysis of pelvic intraoperative neuromonitoring signals
- Best practice: surgeon driven application in pelvic operations
- Vasomotor assessment by camera-based photoplethysmography
- Classification of morphologic changes in photoplethysmographic waveforms
- Novel computation of pulse transit time from multi-channel PPG signals by wavelet transform
- Efficient design of FIR filter based low-pass differentiators for biomedical signal processing
- Nonlinear causal influences assessed by mutual compression entropy
- Comparative study of methods for solving the correspondence problem in EMD applications
- fNIRS for future use in auditory diagnostics
- Semi-automated detection of fractional shortening in zebrafish embryo heart videos
- Blood pressure measurement on the cheek
- Derivation of the respiratory rate from directly and indirectly measured respiratory signals using autocorrelation
- Left cardiac atrioventricular delay and inter-ventricular delay in cardiac resynchronization therapy responder and non-responder
- An automatic systolic peak detector of blood pressure waveforms using 4th order cumulants
- Real-time QRS detection using integrated variance for ECG gated cardiac MRI
- Preprocessing of unipolar signals acquired by a novel intracardiac mapping system
- In-vitro experiments to characterize ventricular electromechanics
- Continuous non-invasive monitoring of blood pressure in the operating room: a cuffless optical technology at the fingertip
- Application of microwave sensor technology in cardiovascular disease for plaque detection
- Artificial blood circulatory and special Ultrasound Doppler probes for detecting and sizing gaseous embolism
- Detection of microsleep events in a car driving simulation study using electrocardiographic features
- A method to determine the kink resistance of stents and stent delivery systems according to international standards
- Comparison of stented bifurcation and straight vessel 3D-simulation with a prior simulated velocity profile inlet
- Transient Euler-Lagrange/DEM simulation of stent thrombosis
- Automated control of the laser welding process of heart valve scaffolds
- Automation of a test bench for accessing the bendability of electrospun vascular grafts
- Influence of storage conditions on the release of growth factors in platelet-rich blood derivatives
- Cryopreservation of cells using defined serum-free cryoprotective agents
- New bioreactor vessel for tissue engineering of human nasal septal chondrocytes
- Determination of the membrane hydraulic permeability of MSCs
- Climate retainment in carbon dioxide incubators
- Multiple factors influencing OR ventilation system effectiveness
- Evaluation of an app-based stress protocol
- Medication process in Styrian hospitals
- Control tower to surgical theater
- Development of a skull phantom for the assessment of implant X-ray visibility
- Surgical navigation with QR codes
- Investigation of the pressure gradient of embolic protection devices
- Computer assistance in femoral derotation osteotomy: a bottom-up approach
- Automatic depth scanning system for 3D infrared thermography
- A service for monitoring the quality of intraoperative cone beam CT images
- Resectoscope with an easy to use twist mechanism for improved handling
- In vitro simulation of distribution processes following intramuscular injection
- Adjusting inkjet printhead parameters to deposit drugs into micro-sized reservoirs
- A flexible standalone system with integrated sensor feedback for multi-pad electrode FES of the hand
- Smart control for functional electrical stimulation with optimal pulse intensity
- Tactile display on the remaining hand for unilateral hand amputees
- Effects of sustained electrical stimulation on spasticity assessed by the pendulum test
- An improved tracking framework for ultrasound probe localization in image-guided radiosurgery
- Improvement of a subviral particle tracker by the use of a LAP-Kalman-algorithm
- Learning discriminative classification models for grading anal intraepithelial neoplasia
- Regularization of EIT reconstruction based on multi-scales wavelet transforms
- Assessing MRI susceptibility artefact through an indicator of image distortion
- EyeGuidance – a computer controlled system to guide eye movements
- A framework for feedback-based segmentation of 3D image stacks
- Doppler optical coherence tomography as a promising tool for detecting fluid in the human middle ear
- 3D Local in vivo Environment (LivE) imaging for single cell protein analysis of bone tissue
- Inside-Out access strategy using new trans-vascular catheter approach
- US/MRI fusion with new optical tracking and marker approach for interventional procedures inside the MRI suite
- Impact of different registration methods in MEG source analysis
- 3D segmentation of thyroid ultrasound images using active contours
- Designing a compact MRI motion phantom
- Cerebral cortex classification by conditional random fields applied to intraoperative thermal imaging
- Classification of indirect immunofluorescence images using thresholded local binary count features
- Analysis of muscle fatigue conditions using time-frequency images and GLCM features
- Numerical evaluation of image parameters of ETR-1
- Fabrication of a compliant phantom of the human aortic arch for use in Particle Image Velocimetry (PIV) experimentation
- Effect of the number of electrodes on the reconstructed lung shape in electrical impedance tomography
- Hardware dependencies of GPU-accelerated beamformer performances for microwave breast cancer detection
- Computer assisted assessment of progressing osteoradionecrosis of the jaw for clinical diagnosis and treatment
- Evaluation of reconstruction parameters of electrical impedance tomography on aorta detection during saline bolus injection
- Evaluation of open-source software for the lung segmentation
- Automatic determination of lung features of CF patients in CT scans
- Image analysis of self-organized multicellular patterns
- Effect of key parameters on synthesis of superparamagnetic nanoparticles (SPIONs)
- Radiopacity assessment of neurovascular implants
- Development of a desiccant based dielectric for monitoring humidity conditions in miniaturized hermetic implantable packages
- Development of an artifact-free aneurysm clip
- Enhancing the regeneration of bone defects by alkalizing the peri-implant zone – an in vitro approach
- Rapid prototyping of replica knee implants for in vitro testing
- Protecting ultra- and hyperhydrophilic implant surfaces in dry state from loss of wettability
- Advanced wettability analysis of implant surfaces
- Patient-specific hip prostheses designed by surgeons
- Plasma treatment on novel carbon fiber reinforced PEEK cages to enhance bioactivity
- Wear of a total intervertebral disc prosthesis
- Digital health and digital biomarkers – enabling value chains on health data
- Usability in the lifecycle of medical software development
- Influence of different test gases in a non-destructive 100% quality control system for medical devices
- Device development guided by user satisfaction survey on auricular vagus nerve stimulation
- Empirical assessment of the time course of innovation in biomedical engineering: first results of a comparative approach
- Effect of left atrial hypertrophy on P-wave morphology in a computational model
- Simulation of intracardiac electrograms around acute ablation lesions
- Parametrization of activation based cardiac electrophysiology models using bidomain model simulations
- Assessment of nasal resistance using computational fluid dynamics
- Resistance in a non-linear autoregressive model of pulmonary mechanics
- Inspiratory and expiratory elastance in a non-linear autoregressive model of pulmonary mechanics
- Determination of regional lung function in cystic fibrosis using electrical impedance tomography
- Development of parietal bone surrogates for parietal graft lift training
- Numerical simulation of mechanically stimulated bone remodelling
- Conversion of engineering stresses to Cauchy stresses in tensile and compression tests of thermoplastic polymers
- Numerical examinations of simplified spondylodesis models concerning energy absorption in magnetic resonance imaging
- Principle study on the signal connection at transabdominal fetal pulse oximetry
- Influence of Siluron® insertion on model drug distribution in the simulated vitreous body
- Evaluating different approaches to identify a three parameter gas exchange model
- Effects of fibrosis on the extracellular potential based on 3D reconstructions from histological sections of heart tissue
- From imaging to hemodynamics – how reconstruction kernels influence the blood flow predictions in intracranial aneurysms
- Flow optimised design of a novel point-of-care diagnostic device for the detection of disease specific biomarkers
- Improved FPGA controlled artificial vascular system for plethysmographic measurements
- Minimally spaced electrode positions for multi-functional chest sensors: ECG and respiratory signal estimation
- Automated detection of alveolar arches for nasoalveolar molding in cleft lip and palate treatment
- Control scheme selection in human-machine- interfaces by analysis of activity signals
- Event-based sampling for reducing communication load in realtime human motion analysis by wireless inertial sensor networks
- Automatic pairing of inertial sensors to lower limb segments – a plug-and-play approach
- Contactless respiratory monitoring system for magnetic resonance imaging applications using a laser range sensor
- Interactive monitoring system for visual respiratory biofeedback
- Development of a low-cost senor based aid for visually impaired people
- Patient assistive system for the shoulder joint
- A passive beating heart setup for interventional cardiology training