Abstract
Dried lemongrass (DLG) herb is high in total phenolic compounds (1,388 mg gallic acid equivalent/100 g), antioxidant scavenging activity (57.88%), and dietary fibers (19.61%), and it also imparts lemon flavor, minerals, and several health benefits. Therefore, it is considered a cost-effective and functional ingredient for various food systems. A trial was conducted to incorporate DLG into a functional low-fat lemon frozen dessert as a fat mimetic and to assess its impacts on physicochemical, rheological, total phenolic compounds, antioxidant scavenging activity, sensory properties, and production costs. A control full-fat frozen dairy dessert (FFD) with 6% fat was prepared for comparison. DLG was added to a low-fat frozen dessert (LFD) with 1% fat at ratios of 0, 0.5, 1.0, and 1.5%. Results showed that FFD had higher rheological characteristics, melting resistance, production costs, and sensory properties compared to LFD. The use of DLG increased mix specific gravity, freezing point depression, apparent viscosity, consistency coefficient index, overrun, total phenolic compounds, and antioxidant scavenging activity while decreasing the pH value compared to LFD. Adding 0.5–1.0% DLG to LFD significantly improved overall acceptability and reduced production costs by 23.80 and 18.56%, respectively. The functional LFD with 0.5–1% DLG achieved comparable quality characteristics to the full-fat treatment.
Graphical abstract
Methodology of functional low-fat frozen dairy dessert production, FFD: full-fat vanilla frozen dairy dessert with 6% fat to serve as a control, LFD: low-fat vanilla frozen dairy dessert (1% fat), T1: as low-fat frozen dairy dessert (1%) supplemented with 0.5% dried lemongrass (DLG), T2: as low-fat frozen dairy dessert (1%) supplemented with 1% DLG, T3: as low-fat frozen dairy dessert (1%) supplemented with 1.5% DLG.

1 Introduction
The tropical plant lemongrass contains a number of concentrated secondary metabolites known as aromatic oils, which serve a variety of functions within the plant system. It contains a variety of chemical substances, including benzenoids, terpenoids, organic sulfur, and nitrogenous compounds. Citral, a combination of two stereoisomeric monoterpene aldehydes, gives lemongrass its distinctive lemon-like odor [1]. It is grown in several countries, including India, Thailand, Korea, Japan, and Egypt [2]. It is well known for its therapeutic benefits, nutritional value, and flavoring industry. People prefer powder-dried leaves to fresh ones because they have a longer shelf life and are simpler to prepare [3]. Its dried form contained 5.1–6.2% crude fat, 27.1–27.6% crude fibers, 7.88–8.13% protein, 53.7–54.6% carbohydrates, 1607.5–1678.8 mg GAE/100 g total phenolic compounds, and flavonoids with high antioxidant activity (AA). It also contains calcium, magnesium, manganese, zinc, copper, iron, potassium, and vitamins (A and C) [4,5,6]. Lemongrass is regarded as one of the particularly useful herbs for human nutrition due to its low cost and versatility as an ingredient in functional foods. Cymbopogon flexuosus, also known as lemongrass, has been used as a folk remedy since ancient times because of its exceptional medicinal properties, which include relieving rheumatic and other pains as well as having a healing effect on ulcers, cancer, and a strong immune system [2,7,8]. Lemongrass has recently gained global attention due to its wide range of industrial applications. Furthermore, it is rich in flavonoids and phenolic compounds, essential oils, and other phytochemical constituents with pharmacological properties that may benefit health, such as anti-inflammatory, anti-obesity, antibacterial, antifungal, anti-nociceptive, and anti-oxidant effects [8]. A number of attempts have been made to improve the flavoring of food, boost AA, or lengthen the shelf life of various food items, including cookies [6], beef burgers [9], orange juice [10], herbal pomegranate aqualete [11], tofu [12], fermented fish [13], yoghurt, yoghurt drink, soy ice cream, and quarg cheese as a natural preservative [14–16]. Also, C. citratus essential oil is commonly used in herbal teas, soups, and curries. It is also suitable for poultry, fish, and seafood [17]. This plant is not poisonous to test organisms and does not exhibit any hypnotic properties [18,19]. Frozen dessert is a complex, aerated food high in nutrients. It includes a variety of flavors, proteins, fats, carbohydrates, and minerals. Milk fat plays a crucial role in frozen dessert’s structural and textural qualities [20–22]. Many chronic diseases, including obesity, cardiovascular disease, and cancer, are thought to be linked to high saturated fat intake [23]. When the fat level of frozen dessert mixes is reduced, the resulting product has a higher melting rate, inferior body and texture properties, a lack of rich flavor, and fewer visible air bubbles than FFI [23]. Food scientists looking forward to develop low-fat frozen dairy desserts based on novel fat substitutes without sacrificing functionality [24–29]. The limited available literature on the use of dried lemongrass (DLG) in frozen dessert production, Chanmchan et al. [30] developed a reduced-sugar herbal ice cream using lemongrass extract. However, in this study, DLG was used as the main source of fiber and as a primary source of antioxidants and phenolic compounds. It was conceived that including DLG in frozen dairy dessert mixes could improve the quality of LFD by lowering production costs. Furthermore, we investigated the functional effects of combining DLG (0.5, 1, and 1.5%) on the physicochemical, rheological, antioxidant scavenging activity, total phenolic compounds, sensory characteristics, and production cost of low-fat frozen dessert, evaluated during storage at −18°C for 28 days.
2 Materials and methods
2.1 Materials
Lemongrass was obtained from a local market. Fresh skim milk (0.3% fat and 9.2% solids non fat (SNF)) and cream (52% fat and 4.05% solids non-fat) were obtained from the Pilot Plant of the Dairy Department, Suez Canal University. Skim milk powder (97% total solids, a product of Dairy America™, USA), vanilla, and sugar (sucrose) were purchased from a local market. Carboxymethyl cellulose (CMC) was purchased from Misr Food Additives. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) was obtained from Sigma Chemical Co. (Saint Louis, MO, USA). The chemicals and solvents utilized consisted of analytical grade.
2.2 Preparing frozen dairy dessert
The frozen dessert mixes (Table 1) were produced according to Marshall and Arbuckle (1996). Skim milk powder is initially mixed with sugar and CMC to generate a “dry mix.” Fresh skim milk was heated to 40°C, and then, fresh cream was incorporated as the temperature went up to 65°C, and the “dry mix” was gradually incorporated while carefully mixing. The mixture was heated at 80°C for 5 min, then immediately subsequent to cooling to 4–5°C. During aging and cooling at 5°C, vanilla powder was added to FFD (6% fat, 10% SNF, 0.30% CMC, 15% sugar) and all low-fat treatments (1% fat, 12% SNF, 15% sugar, 0.30% CMC), while DLG was added at four levels of 0, 0.5, 1.0, and 1.5% to LFD, T1, T2, and T3, respectively. The various mixes were cold stored for 2 h, frozen, and whipped in an ice cream maker (Taylormate™ Model 152, Taylor Company, Blackhawk Blvd., USA). The resultant frozen dessert was collected at −5.5°C, placed in 100 mL plastic cups, covered, hardened at −25°C for one day, and stored at −18°C for analysis. Each treatment was made three times.
The formulation used for making 100 kg of different frozen dairy dessert mixes
| kg/100 kg | |||||
|---|---|---|---|---|---|
| Ingredients | FFD | LFD | T1 | T2 | T3 |
| Sugar | 15 | 15 | 15 | 15 | 15 |
| Skim milk | 70.252 | 78.152 | 77.597 | 77.043 | 76.488 |
| Skim milk powder | 3.315 | 5.076 | 5.127 | 5.178 | 5.230 |
| cream | 11.131 | 1.472 | 1.476 | 1.479 | 1.482 |
| CMC | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 |
| DLG | 0 | 0 | 0.5 | 1.0 | 1.5 |
CMC: carboxymethyl cellulose.
FFD: full-fat vanilla frozen dessert with 6% fat to serve as control.
LGD: low-fat vanilla frozen dessert (1% fat).
T1: low-fat frozen dessert (1%) supplemented with 0.5% DLG.
T2: low-fat frozen dessert (1%) supplemented with 1% DLG.
T3: low-fat frozen dessert (1%) supplemented with 1.5% DLG.
2.3 Preparation of DLG
Fresh lemongrass leaves were cut into approximately 1 cm2 followed by oven drying at 50–60°C. After cooling, the samples were weighed again until a constant weight was recorded. The DLG was ground into fine powder using a high-speed laboratory miller (Braun PowerMax MX 2000 Blender, Germany) as described by Lonkar et al. [31] and frozen at −18°C until use.
2.4 Analysis of DLG
The moisture, protein, total carbohydrates, ash, dietary fibers, and pH values of DLG were analyzed using the AOAC [32]. The iron (Fe), calcium (Ca), and magnesium (Mg) contents of the lemongrass samples were determined according to the methods described by [32–34]. A 0.5 g DLG sample was placed in a 250 mL round-bottom flask. Next, a mixture of acids (2 mL HCl, 3 mL HNO3, and 2 mL HClO4) was added. The round-bottom flask was connected to a reflux condenser and heated to a temperature of 270°C for 1.5 h on a Kjeldahl apparatus hot plate. The digested samples were allowed to cool for ten minutes without detaching the condenser, followed by an additional ten minutes of cooling to room temperature with the condenser removed. To remove any remaining debris, the mixture was diluted with 20 mL of deionized water and filtered through Whatman filter paper No. 42 (Germany) into a 50 mL volumetric flask. The round-bottom flask was further rinsed with 10 mL of deionized water, which was then added to the filtrate. The flask was then filled to the mark with deionized water. Digestion was performed in triplicate for each sample. Standard solutions of Fe, Mg, and Ca were prepared for calibration, and distilled water was used for dilution. The atomic absorption spectroscopy (AAS) instrument was equipped with hollow cathode lamps specific to the elements under study. Triplicate blank samples were digested following the same procedure as the lemongrass samples.
Finally, all the digests were stored in a refrigerator until analysis AAS. Calcium is often determined using a nitrous oxide-acetylene flame because it provides a hotter flame, which reduces chemical interferences, particularly from phosphate. Magnesium is typically analyzed using an air-acetylene flame. The air-acetylene flame is sufficiently hot to atomize magnesium without excessive ionization, which could otherwise reduce sensitivity. Iron is also usually determined using a graphite cuvette with an air-acetylene flame. This flame temperature is adequate to dissociate the iron atoms without causing ionization or chemical interferences. For Ca, strontium (Sr) was used as a matrix modifier to prevent the formation of calcium-phosphate or calcium-sulfate complexes that can reduce the signal. For Mg, palladium was used as a matrix modifier to stabilize magnesium and reduce volatility during the atomization process. For Fe, ammonium phosphate (NH₄H₂PO₄) was used to prevent the formation of refractory oxides of iron. To calibrate the AAS, a range of standard solutions with expected concentrations of calcium, magnesium, and iron were prepared. The appropriate hollow cathode lamps were installed in the AAS instrument, and the following wavelengths were programmed for each element: 248.3 nm for Fe, 285.2 nm for Mg, and 422.7 nm for Ca. After aspirating each standard solution into the AAS, the device plotted each element’s absorbance against concentration to create calibration curves. Additional dilution was performed if the sample concentration exceeded this range. The concentration of each element in the sample solution was determined by the AAS software, with results typically reported in mg/L or ppm. The concentrations were then converted to mg/g using the appropriate formula to express the results in terms of the original DLG sample.
The detection limit for Ca is approximately 0.01–0.05 mg/L (10–50 µg/L), for Mg is approximately 0.001–0.005 mg/L (1–5 µg/L), and for Fe is approximately 0.02–0.05 mg/L (20–50 µg/L).
2.5 Antioxidant scavenging activity and total phenolic compounds analyses
Five grams of the sample were combined in 50 mL of 50% ethanol, agitated for 1 h at room temperature, and filtered through Whatman No. 1 filter paper. Total phenolic compounds (TPC) were analyzed in the ethanolic extract provided by Singleton and Rossi [35] and expressed in mg of gallic acid equivalents per 100 g of sample. Antioxidant scavenging activity (AA) of milk was evaluated in this ethanolic extract by using a DPPH assay [36,37]. For a short while, 1 g of the material was diluted in 95% ethanol. The diluted samples were well combined and centrifuged for 20 min at 4°C at 440 g, and the supernatants were separated for additional examination. A 100 M solution of DPPH in methanol was combined 1:1 with 100 L of samples in a 96-well plate. Following a 30-min incubation period, the samples’ DPPH radical scavenging activity was assessed spectrophotometrically at 517 nm and estimated using the formula below:
2.6 Evaluation of the frozen dessert mix and the final product
Frozen dessert mixes have been examined for specific gravity, freezing point, and weight per gallon of the mix in kilograms as stated by Marshall and Arbuckle [38]. The rheological characteristics of the mix were evaluated after 2 h of aging using a Brookfield viscometer (Brookfield Engineering Laboratories, USA) with a SC4-21 spindle spinning at 50 rpm. At 10°C, shear rates ranging from 23.3 to 232.5 s−1 were measured. Each rheological characteristic underwent three tests. The following were calculated using the measured values of shear stresses and apparent dynamics viscosity: yield stress, plastic viscosity, consistency coefficient index, flow behavior index, and dynamic viscosity (at 50 rpm). Specific gravity, weight per gallon, overrun, and melting rate were analyzed on the frozen dessert samples [38,39]. The sensory organoleptic attributes of fresh frozen dessert from different treatments were assessed by 15 panelists among the staff members. Before being assessed by the senses, the frozen dessert samples were tempered between −15 and −12°C. Scoring evaluation was according to Gafour et al. [40] for flavor (50°C), body and texture (30°C), melting properties (10°C), and color (10°C).
2.7 Production cost
Manufacturing costs for the different mixes were calculated using the current market prices for the ingredients used in frozen dairy dessert production by USD as follows:
| Raw material | Skim milk 0.3% fat | Sugar | Skim milk powder | Cream 55% | CMC | DLG |
|---|---|---|---|---|---|---|
| Price (USD)/kg | 0.47 | 1 | 60 | 5.33 | 4 | 13.33 |
2.8 Microbiological analysis of fermented whey-based beverages
According to Standard Methods for the Examination of Dairy Products [41], the fermented beverage samples were microbiologically analyzed for aerobic bacterial, mold, and yeast count and coliform group.
2.9 Statistical analyses
All assessments were done in triplicates, and The General Linear Model procedure described by Snedcor and Cochran [42] was used in the analysis of variance with one factorial (treatments). Costat was used with Windows software version 6.311, and the least significant difference (±SD) test was used to determine a significant difference (p < 0.01).
3 Results and discussion
3.1 Chemical composition of DLG
Table 2 demonstrates that DLG had higher total solids content (93.83%), with total carbohydrates accounting for the majority (57.33%), as well as good protein content (4.82%), crude fat (5.24%), dietary fibers (19.61%), and ash (6.38%). Aftab et al. [43] and Soars et al. [44] reported similar findings. Lemongrass chemical composition can vary depending on the plant part used, drying conditions, soil salinity, maturity stage, water content in the soil, and time of harvesting [45]. Lemongrass has been shown to have high antimicrobial and AA, which may be explained by its high concentration of bioactive components such as phenolics, anthocyanins, alkaloids, flavonoids, tannins, saponins, isoflavones, terpenes, steroids, coumarins, isocatechins, lignins, catechins, and ascorbic acid [46]. As a result of the phenolic compound concentration, DLG had more TPC and AA than fresh lemongrass. Overall, the drying process increased the total solids of DLG, and as a result, it contained more ash, particularly calcium, magnesium, and iron, than the fresh form. The dried form of lemongrass contained more magnesium (269.5 mg/100 g), calcium (808.9 mg/100 g), and iron (73.6 mg/100 g) [6]. DLG was a great supplier of iron (73.6 mg/100 g), an essential trace element in human nutrition [47]. Milk and its products are relatively low in iron [48], so incorporating DLG into dairy products would improve their nutritional and health benefits. Thus, DLG can be used as a functional ingredient in low-fat frozen dessert.
The proximate analysis of fresh lemongrass and dried form (average of three replicates)
| Constituents | Fresh form | Dried form |
|---|---|---|
| Moisture % | 78.23 ± 1.23 | 6.17 ± 0.23 |
| Crude fibers % | 4.54 ± 0.00 | 19.61 ± 0.40 |
| Protein % | 0.93 ± 0.00 | 4.82 ± 0.12 |
| Total carbohydrates % | 12.69 ± 0.12 | 57.33 ± 1.20 |
| Crude fat % | 1.42 ± 0.01 | 5.24 ± 0.05 |
| Ash % | 1.70 ± 0.02 | 6.83 ± 0.01 |
| Total phenolic compounds (mg gallic acid equivalent/100 g) | 385.4 ± 3.5 | 1388 ± 6.50 |
| Antioxidant scavenging activity % | 13.54 ± 0.11 | 57.88 ± 0.41 |
| Calcium (mg/100 g) | 50.5 ± 0.35 | 808.9 ± 3.50 |
| Magnesium (mg/100 g) | 20.6 ± 0.30 | 269.5 ± 2.14 |
| Iron (mg/100 g) | 6.89 ± 0.05 | 73.6 ± 0.09 |
Means (three different determinations) ± standard deviation (SD).
3.2 Characterization of frozen dessert mixes
Table 3 indicates that different LFD mixes had higher weight (kg) and specific gravity values than full-fat ones, which could be attributed to their higher solids content, not fat, and lower fat content when compared to full-fat one. The addition of DLG resulted in significant increases (p < 0.01) in weight per gallon and specific gravity, which were proportional to the DLG ratio. The increases in specific gravity seen with different low-fat treatments can be explained by the fact that DLG has a specific gravity of 1.355. Because it affects the starting average size and thermodynamic instability of the created ice crystals, which leads to their gradual expansion, freezing point depression (FPD) is an important indicator for monitoring frozen dessert quality [25,49]. As reported by Cognè et al. [50], the FPD of the control frozen dessert mix was −2.46°C. Significant differences in FPD between FFD and CLF were found by statistical analysis because of the variations in SNF contents. The freezing point of frozen dessert is decreased, according to Ohmes et al. [51] when fat is eliminated and replaced with milk solids in place of fat or liquid ingredients. The incorporation of DLG in LFD increased the frozen dessert’s FPD due to an excess of soluble constituents. Soukoulis et al. [52] found a significant (p < 0.01) impact of fiber source on FPD. Thus, the fiber found in wheat, oats, and pectin increased FPD. The pH values of various low-fat mixes were lower than those of full-fat mix, owing to the increase in SNF. Furthermore, the acidic nature of DLG caused the pH of T1, T2, and T3 mixes to drop significantly. Sekhavatizadeh et al. [53] reported a similar finding when they made Kashk with high lemongrass content. Table 3 displays the rheological characteristics of different frozen dessert mixtures. FFD had significantly higher plastic viscosity, apparent viscosity, consistency coefficient index, and yield stress than LFD. This demonstrates the importance of milk fat in forming and supporting the structural characteristics of frozen dessert [20,54]. The incorporation of DLG significantly increased (p < 0.01) the viscosity and consistency coefficient index but decreased the flow behavior index of T1, T2, and T3 compared to LFD. The percentage of added DLG influenced the changes in rheological parameters. These findings could be attributed to the lower pH of these treatments, which resulted in the electric bonding of casein micelles as well as the thickening effect of hydrated DLG fibers [52].
Effect of using different ratios of DLG on the physical and rheological properties of different frozen dessert mixes
| Properties | FFD | LFD | T1 | T2 | T3 |
|---|---|---|---|---|---|
| Specific gravity (g/mL) | 1.0975 ± 0.00e | 1.1084 ± 0.00d | 1.1122 ± 0.00c | 1.1168 ± 0.00b | 1.1235 ± 0.00a |
| Weight per gallon (kg) | 4.9889 ± 0.00e | 5.0385 ± 0.01d | 5.0557 ± 0.00c | 5.0766 ± 0.00b | 5.0980 ± 0.01a |
| Freezing point (°C) | −2.46 ± 0.02a | −2.52 ± 0.02b | −2.54 ± 0.02c | −2.56 ± 0.02d | −2.58 ± 0.02e |
| pH value | 6.58 ± 0.02a | 6.54 ± 0.02b | 6.50 ± 0.02c | 6.47 ± 0.02d | 6.43 ± 0.02e |
| Apparent viscosity (mPas) | 205 ± 2.90c | 125 ± 1.80d | 198 ± 2.50c | 245 ± 3.60b | 310 ± 4.10a |
| Plastic viscosity (mPas) | 141.6 ± 0.80b | 60.9 ± 0.50e | 73.7 ± 0.60d | 113.5 ± 0.80c | 149.7 ± 0.90a |
| Yield stress (N/m2) | 0.87 ± 0.08a | 0.52 ± 0.04e | 0.56 ± 0.05d | 0.62 ± 0.06c | 0.68 ± 0.07b |
| Flow behavior index | 0.515 ± 0.05e | 0.622 ± 0.06a | 0.606 ± 0.06b | 0.586 ± 0.06d | 0.594 ± 0.06c |
| Consistency coefficient index (mPas) | 177.3 ± 1.90a | 94.9 ± 1.20e | 131.9 ± 1.50d | 158.5 ± 1.70b | 147.1 ± 1.60c |
Means with the same column with different superscripts (a, b, c, …) are significantly different ± standard deviation (SD) (p < 0.01).
FFD: full-fat vanilla frozen dessert with 6% fat to serve as control.
LFD: low-fat vanilla frozen dessert (1% fat).
T1: low-fat frozen dessert (1%) supplemented with 0.5% DLG.
T2: low-fat frozen dessert (1%) supplemented with 1% DLG.
T3: low-fat frozen dessert (1%) supplemented with 1.5% DLG.
3.3 Frozen dairy dessert characteristics
Table 4 and Figure 1 show that specific gravity and weight per gallon for different mixes were higher than those of the final products because of the incorporation of air into the frozen dessert matrix during the pre-freezing phase. FFD had a higher overrun (%) than LFD because of the higher rheological characteristics. So, the weight per gallon and the specific gravity of FFD were lower than those of the LFD. While incorporating 0.5–1.5% DLG for T1, T2, and T3 increased the overrun percentage as compared to LFD, this phenomenon was correlated to the impact of using the DLG to enhance the mix’s viscosity. Figure 1 shows the full melting rates of various frozen dessert samples as affected by fat reduction and DLG use. Melting resistance refers to the taken time for frozen dessert to melt at 25 ± 1°C. The control full-fat frozen dessert sample melted slower than the LFD. This could be due to fat’s fundamental role in frozen dessert’s structural properties and lower heat conductivity, which would explain the earlier effects [52]. Khalil and Kholoud [55,56] reported similar findings. Incorporation of DLG into frozen dessert of T1, T2, and T3 led to higher melting resistance as compared to LFD (Figure 1). The added solids in DLG, including dietary fiber content, may have contributed to a consistent, smooth body, and texture, as well as higher rheological characteristics with increased melting resistance [57].
Effect of using different ratios of DLG on the physical properties of the resultant frozen dessert treatments (average of three replicates)
| Properties | FFD | LFD | T1 | T2 | T3 |
|---|---|---|---|---|---|
| Specific gravity (g/mL) | 0.684 ± 0.01e | 0.750 ± 0.10a | 0.741 ± 0.10b | 0.733 ± 0.01c | 0.722 ± 0.01d |
| Weight (kg) | 11.783 ± 0.05e | 12.920 ± 0.05a | 12.764 ± 0.05b | 12.628 ± 0.05c | 12.438 ± 0.05d |
| % overrun | 60.45 ± 0.24a | 47.79 ± 0.16e | 50.09 ± 0.19d | 52.36 ± 0.24c | 55.33 ± 0.28b |
Means with the same column with different superscripts (a, b, c, …) significantly different ± standard deviation (SD) (p < 0.01).
FFD: full-fat vanilla frozen dessert with 6% fat to serve as control.
LFD: low-fat vanilla frozen dessert (1% fat).
T1: low-fat frozen dessert (1%) supplemented with 0.5% DLG.
T2: low-fat frozen dessert (1%) supplemented with 1% DLG.
T3: low-fat frozen dessert (1%) supplemented with 1.5% DLG .

The differences in melting rate expressed as % loss of different frozen dairy dessert samples at intervals during 1 h at 25°C (average of three replicates).
3.4 Bioactive compounds of frozen dessert
Figure 2a and b depicts the adjustments in TPC and AA of frozen dessert treatments during frozen storage as influenced by DLG throughout 28 days of frozen storage. FFD had lower TPC and AA than LFD. It has been demonstrated that LFD has higher protein content with higher AA [58]. While using 0.5–1.5% DLG in frozen dessert significantly increased (p < 0.01) the TPC and AA levels of treated samples. TPC and AA for all samples decreased gradually over longer frozen storage periods, possibly due to frozen dessert oxidation. Eldeeb et al. [59] found similar results when they sampled frozen yoghurt with DLG. Also, this finding is in agree with Yosefiyan et al. [29], who indicated that adding dried persimmon peel powder has the potential to be applied as an added-value ingredient in the ice cream industry to improve the functional characteristics of its products.

Effect of using different percentages of DLG on total phenolic compounds (TPC) expressed as mg gallic acid equivalent/100 g (a) and antioxidant scavenging activity (AA) % (b) of different frozen dairy dessert samples during the freeze storage (average of three replicates).
3.5 Production cost
Table 5 presents the processing costs of various frozen dessert treatments as a result of using DLG and lowering the fat content, which were calculated using the local market prices. FFD had the most expensive production costs. Production costs were lowered by 29.06% because of the mix’s decreased usage of cream due to the 1% fat specification. Utilizing substantial DLG at ratios of 0.5, 1.0, and 1.5% for T1, T2, and T3 reduced production costs by 23.80, 18.56, and 13.30%, respectively, when compared to FFD. However, these prices were considerably higher than that of LFD because of the higher price of DLG (13.33 USD) than other dairy ingredients. Similar results were observed by Abdeldaiem et al. [26], who indicated that the production cost and profit of the ice cream supplemented with corn powders were lower compared to the control sample.
Effect of using different ratios of DLG on cost of production of frozen dessert treatments (USD) (average of three replicates)
| Properties | FFD | LFD | T1 | T2 | T3 |
|---|---|---|---|---|---|
| Cost of production | 128.24 ± 0.75a | 90.98 ± 0.11e | 97.91 ± 0.07d | 104.44 ± 0.09c | 111.18 ± 0.31b |
| % reduction of cost as compared to full-fat one | — | 29.05 ± 0.12a | 23.80 ± 0.09b | 18.56 ± 0.07c | 13.30 ± 0.22d |
Means with the same column with different superscripts (a, b, c, …) significantly different ± standard deviation (SD) (p < 0.01).
FFD: full-fat vanilla frozen dessert with 6% fat to serve as control.
LFD: low-fat vanilla frozen dessert (1% fat).
T1: low-fat frozen dessert (1%) supplemented with 0.5% DLG.
T2: low-fat frozen dessert (1%) supplemented with 1% DLG.
T3: low-fat frozen dessert (1%) supplemented with 1.5% DLG.
3.6 Sensory properties
Table 6 displays the sensory attribute scores for various frozen dessert treatments as affected by fat reduction and using DLG during 28 days of frozen storage. FFD had a creamy taste and a rich mouth feel, and it received the highest scores for body, texture, and flavor among all treatments. It has been established that milk fat contributes to the formation and quality of frozen dessert generally [20]. Panelists described the decreased-fat frozen dessert as having a more icy body and texture, fewer air bubbles, and stability. Incorporating DLG fibers into the frozen dessert matrix improved the good body and texture characteristic with the intensity of lemon flavor as well as total acceptability scores as compared to LFD. Generally, the incorporation of DLG fibers in the ice cream improved the body and texture of the finished product and reduced the proportion of frozen water in the resultant ice cream [52]. On the other hand, using 1.5% DLG in frozen dessert had an adverse effect on the flavor characterized by an unacceptable stronger lemon flavor with lower total acceptability scores than those made with 0.5–1% DLG. Similar findings were reported by using DLG in frozen yoghurt by Eldeeb et al. [59].
Effect of using different ratios of DLG on sensory evaluation of frozen dessert treatments (average of three replicates)
| Properties | FFD | LFD | T1 | T2 | T3 |
|---|---|---|---|---|---|
| After 1 day of freeze storage | |||||
| Flavor (50 points) | 48.0 | 40.0 | 47.5 | 47.0 | 46.5 |
| Body and texture (30 points) | 28.5 | 23.5 | 27.5 | 28.0 | 28.0 |
| Melting properties (10 points) | 9.5 | 7.5 | 8.5 | 8.5 | 8.0 |
| Color (10 points) | 9.5 | 8.0 | 9 | 9.0 | 8.5 |
| Total acceptability | 95.5 ± 0.7a | 79.0 ± 0.7d | 92.5 ± 0.7b | 92.5 ± 0.7b | 91.0 ± 0.7c |
| After 28 days of freeze storage | |||||
| Flavor (50 points) | 46.5 | 38 | 46 | 46 | 45.5 |
| Body and texture (30 points) | 28 | 22.0 | 27.0 | 27.0 | 27.5 |
| Melting properties (10 points) | 9.0 | 6.5 | 8.5 | 8.5 | 8.0 |
| Color (10 points) | 8.5 | 7.5 | 8.5 | 8.5 | 8.0 |
| Total acceptability | 92.0 ± 0.3a | 74.0 ± 0.3d | 90.0 ± 0.2b | 90.0 ± 0.3b | 89.0 ± 0.3c |
Means with the same column with different superscripts (a, b, c, …) significantly different ± standard deviation (SD) (p < 0.01).
FFD: full-fat vanilla frozen dessert with 6% fat to serve as control.
LFD: low-fat vanilla frozen dessert (1% fat).
T1: low-fat frozen dessert (1%) supplemented with 0.5% DLG.
T2: low-fat frozen dessert (1%) supplemented with 1% DLG.
T3: low-fat frozen dessert (1%) supplemented with 1.5% DLG.
3.7 Microbiological properties
No presence of coliform bacteria, mold, or yeasts was observed in any of the samples throughout the storage period (28 days), and this may be explained by the good manufacturing practices of the product and hygienic settings. These results are in agreement with [60,61].
4 Conclusions
Ultimately, it could be concluded that DLG can be successfully used in the production of low-fat frozen dairy dessert as a functional ingredient to impart a mild lemon flavor, dietary fibers, and phenolic compounds, thereby improving product quality and anti-oxidative activity. As a result, it is recommended to use DLG in the preparation of low-fat frozen dessert at a ratio of 0.5–1.0% to obtain a product with good quality characteristics while lowering production costs by 18.56–23.80%, respectively. The use of DLG can be expanded beyond frozen desserts to other low-fat dairy products, such as yogurt, cheese, and smoothies, to capitalize on its functional and nutritional benefits. Further research should focus on optimizing the ratio of DLG in various dairy products to ensure the best balance between flavor, texture, and health benefits. While 0.5–1.0% is recommended for frozen desserts, other products might require different concentrations. Further investigation into the health impacts of regular consumption of DLG-infused dairy products can help establish their role in promoting well-being, potentially positioning them as functional foods in the market.
Acknowledgments
The authors thank Researchers Supporting Project number (RSPD2024R641), King Saud University, Riyadh, Saudi Arabia, for funding this research.
-
Author contributions: Rafik A. M. Khalil: conceptualization, data curation, formal analysis, investigation, methodology, resources, software, supervision, writing – review & editing. Talaat H. El-Sawah: data curation, formal analysis, writing – original draft. Tawfiq Alsulami: writing – review & editing, funding acquisition. Ayah T. Zaidalkilani: writing – review & editing, funding acquisition. Ammar AL-Farga: writing – review & editing, funding acquisition. Wael F. Elkot: conceptualization, data curation, formal analysis, investigation, methodology, resources, software, supervision, writing – review & editing.
-
Conflict of interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article. The authors have declared that there is no conflict of interest.
-
Ethical approval: Ethics approval was not required for this research.
-
Data availability statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
References
[1] Majewska E, Kozlowska M, Gruszczynska-Sekowska E, Kowalska D, Tarnowska K. Lemongrass (Cymbopogon citratus) essential oil: extraction, composition bioactivity and uses for food preservation-a review. Polish J Food Nutr Sci. 2019;69(4):327–41.10.31883/pjfns/113152Suche in Google Scholar
[2] Singh SR, Kumar A. Lemongrass a wonder herb of Poaceae Family: An overview. Biol Forum Int J. 2021;13(2):298–308.Suche in Google Scholar
[3] AlWaili MA. Protective effects of lemongrass (Cymbopogon citratus STAPF) extract mediated mitochondrial fission and glucose uptake inhibition in SW1417. Food Sci Technol. 2023;43:e94522.10.1590/fst.94522Suche in Google Scholar
[4] Ranade SS, Thiagarajan P. Lemon grass. Int J Pharma Sci Res. 2015;35(2):162–7.Suche in Google Scholar
[5] Kiani HS, Aly A, Shama ZHZ, Kubra KT, Azam M, Zahid HF. Phytochemical composition and pharmacological potential of Lemongrass (Cymbopogon) and impact on gut microbiota. Appl Chem. 2022;2:229–46.10.3390/appliedchem2040016Suche in Google Scholar
[6] Fayad SS, Nasser MEA. Using lemongrass in functional food production. Alex Sci Exch J. 2023;44(2):237–41.10.21608/asejaiqjsae.2023.307123Suche in Google Scholar
[7] Fenwick GR, Lutomski L, Nieman C. Licorice; glycyrrhiza global. composition, uses and analyses. Food Chem. 1990;38:119–43. J Food Sci. 54(1):74–6 .10.1016/0308-8146(90)90159-2Suche in Google Scholar
[8] Thasrin FJ, Anitha V. Nutritional and nutraceutical potentials of lemongrass (Cymbopogon citratus). Int J Curr Sci Res Rev. 2023;6(5):2881–6.Suche in Google Scholar
[9] Awad SMS. Utilization of lemongrass leaves powder (Cymbopogon citratus) in improving beef burger. Austr J Basic Appl Sci. 2019;18(3):8–17.Suche in Google Scholar
[10] Adjou E, Ahoussi ED, Dègnon RG, Mongazi C, Soumanou MM, Sohounhloue D. Effects of essential oil from Cymbopogon citratus leaves and its susceptibility on the quality of fresh orange juice during storage. Int J Health Anim Sci Food Saf. 2017;4(1).Suche in Google Scholar
[11] Chaturvedi N, Sahrawat N, Gupta D. Development of functional herbal pomegranate aqualete enriched with coffea arabica and Cymbopogon citratus. J Nat Prod Res. 2017;3(2):119–21.Suche in Google Scholar
[12] Hamad A, Neurleili E, Pradani DY, Djalil AD, Haratanti D. Application of lemongrass as natural preservatives of tofu. J Teknol ind Pangan. 2019;30(2):100–9.10.6066/jtip.2019.30.2.100Suche in Google Scholar
[13] Dègnon RG, Allagbé AC, Adjou ES, Dahouenon-Ahoussi E. Antifungal activities of Cymbopogon citratus essential oil against Aspergillus species isolated from fermented fish products of Southern Benin. J Food Qual Hazards Cont. 2019;6(2):53–7.10.18502/jfqhc.6.2.955Suche in Google Scholar
[14] Abd-El Fattah Sh M, Abo Sree YH, Bayoum HM, Eissa HA. The use of lemongrass extracts as antimicrobial and food additive potential in yoghurt. J Am Sci. 2010;6(11):582–94.Suche in Google Scholar
[15] Natisri S, Mahattanatawee K, Thaiudom S. Improving the flavor of soy ice cream by adding lemongrass or Pandan leaf extracts. Food Appl Biosci. 2014;13(1):469–84.10.12982/CMUJNS.2014.0050Suche in Google Scholar
[16] Elkot WF, El-Deeb AM, Hefny SG, Bakr AShT. Antioxidant activity, rheological, and sensory properties of functional goat milk yoghurt drink using some plant extracts. Aswan Univ J Sci Technol. 2023;1(2):109–23.10.21608/aujst.2023.312710Suche in Google Scholar
[17] Anggraeni NI, Hidayat IW, Rachman SD. Bioactivity of essential oil from lemongrass (Cymbopogon citratus Stapf.) as an antioxidant agent. AIP Conf Proc. 2017;1927:030007.10.1063/1.5021200Suche in Google Scholar
[18] Negrelle RRB, Gomes EC. Cymbopogon Citratus (DC) Stapf: chemical composition and biological activities. Rev Bras PI Med Botucatu. 2007;9(1):80–92.Suche in Google Scholar
[19] Aibinu I, Adenipekun T, Adelowotan T, Ogunsanya T, Odugbemi T. Evaluation of the antimicrobial properties of different parts of Citrus aurantifolia (lime fruit) as used locally. Afr J Tradit Complement Alt Med. 2007;4(2):185.Suche in Google Scholar
[20] Turgut T, Cakmacki S. Investigation of the possible use of probiotics in ice cream manufacture. Int J Dairy Technol. 2009;62:444–51.10.1111/j.1471-0307.2009.00494.xSuche in Google Scholar
[21] Elkot WF, Ismail HA, Rayan AM. Enhancing the functional properties and nutritional quality of ice milk with sebesten fruits (Cordia myxa L.). Egypt J Food Sci. 2017;45:125–34.Suche in Google Scholar
[22] Şimşek B, Gün I. Some physicochemical, rheological and sensory properties of flavored ice cream. J Eng Sci. 2021;10(2):598–605.10.28948/ngumuh.911167Suche in Google Scholar
[23] Rolon ML, Bakke AJ, Coupland JN, Hayes JE, Roberts RF. Effect of fat content on the physical properties and consumer acceptability of vanilla ice cream. J Dairy Sci. 2017;100:5217–24.10.3168/jds.2016-12379Suche in Google Scholar PubMed
[24] Shahi SK, Didar Z, Hesarinejad MA, Vazifedoost M. Optimized pulsed electric field-assisted extraction of biosurfactants from Chubak (Acanthophyllum squarrosum) root and application in ice cream. J Sci Food Agric. 2021;101(9):3693–706.10.1002/jsfa.11000Suche in Google Scholar PubMed
[25] Ghaderi S, Tehrani MM, Hesarinejad MA. Qualitative analysis of the structural, thermal and rheological properties of a plant ice cream based on soy and sesame milks. Food Sci Nut. 2021;9:1289–98.10.1002/fsn3.2037Suche in Google Scholar PubMed PubMed Central
[26] Abdeldaiem AM, Ali AH, Mousa AH, Elkot WF, Simal-Gandara J. Ice cream supplemented with roasted and grilled corn powders: Physical properties, rheology, antioxidant activity, color, sensory evaluation, and production cost. Int J Gast Food Sci. 2023;32:100692.10.1016/j.ijgfs.2023.100692Suche in Google Scholar
[27] El-Maksoud AA, Hesarinejad MA, Abedelmaksoud TG. Exploring the potential of sprouted soybean and sesame hull to increase nutritional value of ice cream. Food Syst. 2023;6(3):403–8.10.21323/2618-9771-2023-6-3-403-408Suche in Google Scholar
[28] Shadordizadeh T, Mahdian E, Hesarinejad MA. Application of encapsulated Indigofera tinctoria extract as a natural antioxidant and colorant in ice cream. Food Sci Nut. 2023;11:1940–51.10.1002/fsn3.3228Suche in Google Scholar PubMed PubMed Central
[29] Yosefiyan M, Mahdian E, Kordjazi A, Hesarinejad MA. Freeze-dried persimmon peel: A potential ingredient for functional ice cream. Heliyon. 2024;10:e25488.10.1016/j.heliyon.2024.e25488Suche in Google Scholar PubMed PubMed Central
[30] Chamchan R, Sinchaipanit P, Disnil S, Jittinandana S, Nitithamyong A, On-nom N. Formulation of reduced sugar herbal ice cream using lemongrass or ginger extract. Br Food J. 2017;119(10):2172–82.10.1108/BFJ-10-2016-0502Suche in Google Scholar
[31] Lonkar PB, Chavan UD, Pawar VD, Bansode VV, Amarowicz R. Studies on preparation and preservation of lemongrass (Cymbopogon flexuosus (Steud) Wats) powder for tea. Emirates J Food Agric. 2013;25(8):585–92.10.9755/ejfa.v25i8.15218Suche in Google Scholar
[32] AOAC. Official methods of analysis. 19th edn. USA: Association of Official Analysis Chemists Inc; 2007.Suche in Google Scholar
[33] Jorhem L. Determination of metals in foodstuffs by atomic absorption spectrophotometer after dry ashing. NMKL interlaboratory study of lead, cadmium, zinc, copper, iron, chromium and nickel. J AOAC Int. 1993;76:798.10.1093/jaoac/76.4.798Suche in Google Scholar
[34] Birhanu N, Yohannes W, Singh B. Determination of selected major and trace metals in lemongrass (Cymbopogon citratus) by microwave plasma-atomic emission spectrometry. Ethiop J Sci. 2021;44(2):205–14.10.4314/sinet.v44i2.7Suche in Google Scholar
[35] Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic–phosphotungstic acid reagents. Am J Enol Vitic. 1965;16:144.10.5344/ajev.1965.16.3.144Suche in Google Scholar
[36] Burits M, Bucar F. Antioxidant activity of Nigella sativa essential oil. Phyto Res. 2000;14:323.10.1002/1099-1573(200008)14:5<323::AID-PTR621>3.0.CO;2-QSuche in Google Scholar
[37] Cuendet MKH, Potterat O. Iridoidglucosides with free radical scavenging properties from Fagraea blumei. Helvetica Chim Acta. 1997;80:1144.10.1002/hlca.19970800411Suche in Google Scholar
[38] Marshall RT, Arbuckle WS. Ice cream. 5th edn. New York, USA: Chapman and Hall; 1996.10.1007/978-1-4613-0477-7Suche in Google Scholar
[39] Segall KI, Goff HD. A modified ice cream processing routine that promotes fat destabilization in the absence of added emulsifier. Int Dairy J. 2002;12:1013.10.1016/S0958-6946(02)00117-6Suche in Google Scholar
[40] Gafour WA, Essawy EAY, Salem AS. Incorporation of natural antioxidants into ice cream. Egypt J Dairy Sci. 2007;35:117.Suche in Google Scholar
[41] Marshall RT. Standard methods for the examination of dairy products. Washington, DC, USA: American Public Health Association; 1992.Suche in Google Scholar
[42] Snedcor GW, Cochran WG. Statistical methods. 6th edn. Iowa, U.S.A: Iowa State University Press; 1967.Suche in Google Scholar
[43] Aftab K, Ali MD, Aijaz P, Beena N, Gulzar HJ, Sheikh K. Determination of different trace and essential element in lemongrass samples by x-ray flouresence spectroscopy technique. Int Food Res J. 2011;18:265–70.Suche in Google Scholar
[44] Soares MO, Alves RC, Pires PC, Oliveira MBP, Vinha AF. Angolan Cymbopogon citratus used for therapeutic benefits: Nutritional composition and influence of solvents in phytochemicals content and antioxidant activity of leaf extracts. Food Chem Toxic. 2013;60:413–8.10.1016/j.fct.2013.07.064Suche in Google Scholar
[45] Idrees M, Naeem M, Khan M, Aftab T, Tariq M. Alleviation of salt stress in lemongrass by salicylic acid. Protoplasma. 2012;249(3):709–18.10.1007/s00709-011-0314-1Suche in Google Scholar
[46] Tavares F, Costa G, Francisco V, Liberal J, Figueirinha A, Lopes MC, et al. Cymbopogon citratus industrial waste as a potential source of bioactive compounds. J Sci Food Agric. 2015;95:2652–9.10.1002/jsfa.6999Suche in Google Scholar PubMed
[47] Rodolfo, AJ. Ascorbic acid supplementation and vitamin A fortification of anemic Filipino children and its effect on iron nutriture. Vol. 277 AAT. PhD thesis. United States – New York: Cornell University; 1983. p. 8309470.Suche in Google Scholar
[48] Flynn A. Minerals and trace elements in milk. Adv Food Nutr Res. 1992;36:209.10.1016/S1043-4526(08)60106-0Suche in Google Scholar
[49] Hartel RW. Crystallization in foods. 1st edn. Gaithersburg, Maryland: Aspen Publishers Inc; 2001.Suche in Google Scholar
[50] Cognè C, Andrieu J, Laurent P, Besson A, Nocquet J. Experimental data and modeling of thermal properties of ice cream. J Food Eng. 2003;58:331.10.1016/S0260-8774(02)00396-5Suche in Google Scholar
[51] Ohmes RL, Marshall RT, Heymann H. Sensory and physical properties of ice creams containing milk fat or fat replacers. J Dairy Sci. 1998;81:1222.10.3168/jds.S0022-0302(98)75682-6Suche in Google Scholar PubMed
[52] Soukoulis C, Lebesi D, Tzia C. Enrichment of ice cream with dietary fibre: Effects on rheological properties, ice crystallization and glass transition phenomena. Food Chem. 2009;115:665–73.10.1016/j.foodchem.2008.12.070Suche in Google Scholar
[53] Sekhavatizadeh SS, Banisaeed K, Hasanzadeh M, Khalatbari-Limaki S, Amininezhad H. Physicochemical properties of kashk supplemented with encapsulated lemongrass extract. Foods Raw Mater. 2023;11(1):141–51.10.21603/2308-4057-2023-1-560Suche in Google Scholar
[54] Elkot WF. Functional dairy foods: A review. J Agroa Process Technol. 2022;28(3):223–5.Suche in Google Scholar
[55] Khalil RAM, Kholoud IB. Novel functional low fat ice cream flavoured with roasted date seed. Egypt J Dairy Sci. 2016;44:137–49.Suche in Google Scholar
[56] Khalil RAM, Kholoud IB. Preparation and properties of low fat ice cream supplemented with baked sweet potato puree. Egypt J Dairy Sci. 2019;47:61–70.Suche in Google Scholar
[57] Regand A, Goff HD. Structure and ice recrystallisation in frozen stabilised ice cream model systems. Food Hydroc. 2003;17:95–102.10.1016/S0268-005X(02)00042-5Suche in Google Scholar
[58] Lindmark-Mansson H, Akesson B. Antioxidative factors in milk. Br J Nutr. 2000;84:103.10.1017/S0007114500002324Suche in Google Scholar PubMed
[59] Eldeeb GS, Abouelnaga M, Mosilhey SM. Improving quality properties of frozen yogurt by fortification with lemongrass (Cymbopogon citratus) as prebiotic. J Food Sci Suez Canal Univ. 2021;8(1):1–8.10.21608/scuj.2021.178514Suche in Google Scholar
[60] Elkot WF, Ateteallah AH, Al-Moalem MH, Shahein MR, Alblihed MA, Abdo W, et al. Functional, physicochemical, rheological, microbiological, and organoleptic properties of synbiotic ice cream produced from camel milk using black rice powder and Lactobacillus acidophilus LA-5. Fermentation. 2022;8:187. 10.3390/fermentation8040187.Suche in Google Scholar
[61] Shahein MR, Elkot WF, Albezrah NKA, Abdel-Hafez LJM, Alharbi MA, Massoud D, et al. Insights into the microbiological and physicochemical properties of bio-frozen yoghurt made with probiotic strains in combination with Jerusalem artichoke tubers powder. Fermentation. 2022;8:390.10.3390/fermentation8080390Suche in Google Scholar
© 2024 the author(s), published by De Gruyter
This work is licensed under the Creative Commons Attribution 4.0 International License.
Artikel in diesem Heft
- Regular Articles
- Porous silicon nanostructures: Synthesis, characterization, and their antifungal activity
- Biochar from de-oiled Chlorella vulgaris and its adsorption on antibiotics
- Phytochemicals profiling, in vitro and in vivo antidiabetic activity, and in silico studies on Ajuga iva (L.) Schreb.: A comprehensive approach
- Synthesis, characterization, in silico and in vitro studies of novel glycoconjugates as potential antibacterial, antifungal, and antileishmanial agents
- Sonochemical synthesis of gold nanoparticles mediated by potato starch: Its performance in the treatment of esophageal cancer
- Computational study of ADME-Tox prediction of selected phytochemicals from Punica granatum peels
- Phytochemical analysis, in vitro antioxidant and antifungal activities of extracts and essential oil derived from Artemisia herba-alba Asso
- Two triazole-based coordination polymers: Synthesis and crystal structure characterization
- Phytochemical and physicochemical studies of different apple varieties grown in Morocco
- Synthesis of multi-template molecularly imprinted polymers (MT-MIPs) for isolating ethyl para-methoxycinnamate and ethyl cinnamate from Kaempferia galanga L., extract with methacrylic acid as functional monomer
- Nutraceutical potential of Mesembryanthemum forsskaolii Hochst. ex Bioss.: Insights into its nutritional composition, phytochemical contents, and antioxidant activity
- Evaluation of influence of Butea monosperma floral extract on inflammatory biomarkers
- Cannabis sativa L. essential oil: Chemical composition, anti-oxidant, anti-microbial properties, and acute toxicity: In vitro, in vivo, and in silico study
- The effect of gamma radiation on 5-hydroxymethylfurfural conversion in water and dimethyl sulfoxide
- Hollow mushroom nanomaterials for potentiometric sensing of Pb2+ ions in water via the intercalation of iodide ions into the polypyrrole matrix
- Determination of essential oil and chemical composition of St. John’s Wort
- Computational design and in vitro assay of lantadene-based novel inhibitors of NS3 protease of dengue virus
- Anti-parasitic activity and computational studies on a novel labdane diterpene from the roots of Vachellia nilotica
- Microbial dynamics and dehydrogenase activity in tomato (Lycopersicon esculentum Mill.) rhizospheres: Impacts on growth and soil health across different soil types
- Correlation between in vitro anti-urease activity and in silico molecular modeling approach of novel imidazopyridine–oxadiazole hybrids derivatives
- Spatial mapping of indoor air quality in a light metro system using the geographic information system method
- Iron indices and hemogram in renal anemia and the improvement with Tribulus terrestris green-formulated silver nanoparticles applied on rat model
- Integrated track of nano-informatics coupling with the enrichment concept in developing a novel nanoparticle targeting ERK protein in Naegleria fowleri
- Cytotoxic and phytochemical screening of Solanum lycopersicum–Daucus carota hydro-ethanolic extract and in silico evaluation of its lycopene content as anticancer agent
- Protective activities of silver nanoparticles containing Panax japonicus on apoptotic, inflammatory, and oxidative alterations in isoproterenol-induced cardiotoxicity
- pH-based colorimetric detection of monofunctional aldehydes in liquid and gas phases
- Investigating the effect of resveratrol on apoptosis and regulation of gene expression of Caco-2 cells: Unravelling potential implications for colorectal cancer treatment
- Metformin inhibits knee osteoarthritis induced by type 2 diabetes mellitus in rats: S100A8/9 and S100A12 as players and therapeutic targets
- Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized rats
- Synthesis of new analogs of N-substituted(benzoylamino)-1,2,3,6-tetrahydropyridines
- Response of yield and quality of Japonica rice to different gradients of moisture deficit at grain-filling stage in cold regions
- Preparation of an inclusion complex of nickel-based β-cyclodextrin: Characterization and accelerating the osteoarthritis articular cartilage repair
- Empagliflozin-loaded nanomicelles responsive to reactive oxygen species for renal ischemia/reperfusion injury protection
- Preparation and pharmacodynamic evaluation of sodium aescinate solid lipid nanoparticles
- Assessment of potentially toxic elements and health risks of agricultural soil in Southwest Riyadh, Saudi Arabia
- Theoretical investigation of hydrogen-rich fuel production through ammonia decomposition
- Biosynthesis and screening of cobalt nanoparticles using citrus species for antimicrobial activity
- Investigating the interplay of genetic variations, MCP-1 polymorphism, and docking with phytochemical inhibitors for combatting dengue virus pathogenicity through in silico analysis
- Ultrasound induced biosynthesis of silver nanoparticles embedded into chitosan polymers: Investigation of its anti-cutaneous squamous cell carcinoma effects
- Copper oxide nanoparticles-mediated Heliotropium bacciferum leaf extract: Antifungal activity and molecular docking assays against strawberry pathogens
- Sprouted wheat flour for improving physical, chemical, rheological, microbial load, and quality properties of fino bread
- Comparative toxicity assessment of fisetin-aided artificial intelligence-assisted drug design targeting epibulbar dermoid through phytochemicals
- Acute toxicity and anti-inflammatory activity of bis-thiourea derivatives
- Anti-diabetic activity-guided isolation of α-amylase and α-glucosidase inhibitory terpenes from Capsella bursa-pastoris Linn.
- GC–MS analysis of Lactobacillus plantarum YW11 metabolites and its computational analysis on familial pulmonary fibrosis hub genes
- Green formulation of copper nanoparticles by Pistacia khinjuk leaf aqueous extract: Introducing a novel chemotherapeutic drug for the treatment of prostate cancer
- Improved photocatalytic properties of WO3 nanoparticles for Malachite green dye degradation under visible light irradiation: An effect of La doping
- One-pot synthesis of a network of Mn2O3–MnO2–poly(m-methylaniline) composite nanorods on a polypyrrole film presents a promising and efficient optoelectronic and solar cell device
- Groundwater quality and health risk assessment of nitrate and fluoride in Al Qaseem area, Saudi Arabia
- A comparative study of the antifungal efficacy and phytochemical composition of date palm leaflet extracts
- Processing of alcohol pomelo beverage (Citrus grandis (L.) Osbeck) using saccharomyces yeast: Optimization, physicochemical quality, and sensory characteristics
- Specialized compounds of four Cameroonian spices: Isolation, characterization, and in silico evaluation as prospective SARS-CoV-2 inhibitors
- Identification of a novel drug target in Porphyromonas gingivalis by a computational genome analysis approach
- Physico-chemical properties and durability of a fly-ash-based geopolymer
- FMS-like tyrosine kinase 3 inhibitory potentials of some phytochemicals from anti-leukemic plants using computational chemical methodologies
- Wild Thymus zygis L. ssp. gracilis and Eucalyptus camaldulensis Dehnh.: Chemical composition, antioxidant and antibacterial activities of essential oils
- 3D-QSAR, molecular docking, ADMET, simulation dynamic, and retrosynthesis studies on new styrylquinolines derivatives against breast cancer
- Deciphering the influenza neuraminidase inhibitory potential of naturally occurring biflavonoids: An in silico approach
- Determination of heavy elements in agricultural regions, Saudi Arabia
- Synthesis and characterization of antioxidant-enriched Moringa oil-based edible oleogel
- Ameliorative effects of thistle and thyme honeys on cyclophosphamide-induced toxicity in mice
- Study of phytochemical compound and antipyretic activity of Chenopodium ambrosioides L. fractions
- Investigating the adsorption mechanism of zinc chloride-modified porous carbon for sulfadiazine removal from water
- Performance repair of building materials using alumina and silica composite nanomaterials with electrodynamic properties
- Effects of nanoparticles on the activity and resistance genes of anaerobic digestion enzymes in livestock and poultry manure containing the antibiotic tetracycline
- Effect of copper nanoparticles green-synthesized using Ocimum basilicum against Pseudomonas aeruginosa in mice lung infection model
- Cardioprotective effects of nanoparticles green formulated by Spinacia oleracea extract on isoproterenol-induced myocardial infarction in mice by the determination of PPAR-γ/NF-κB pathway
- Anti-OTC antibody-conjugated fluorescent magnetic/silica and fluorescent hybrid silica nanoparticles for oxytetracycline detection
- Curcumin conjugated zinc nanoparticles for the treatment of myocardial infarction
- Identification and in silico screening of natural phloroglucinols as potential PI3Kα inhibitors: A computational approach for drug discovery
- Exploring the phytochemical profile and antioxidant evaluation: Molecular docking and ADMET analysis of main compounds from three Solanum species in Saudi Arabia
- Unveiling the molecular composition and biological properties of essential oil derived from the leaves of wild Mentha aquatica L.: A comprehensive in vitro and in silico exploration
- Analysis of bioactive compounds present in Boerhavia elegans seeds by GC-MS
- Homology modeling and molecular docking study of corticotrophin-releasing hormone: An approach to treat stress-related diseases
- LncRNA MIR17HG alleviates heart failure via targeting MIR17HG/miR-153-3p/SIRT1 axis in in vitro model
- Development and validation of a stability indicating UPLC-DAD method coupled with MS-TQD for ramipril and thymoquinone in bioactive SNEDDS with in silico toxicity analysis of ramipril degradation products
- Biosynthesis of Ag/Cu nanocomposite mediated by Curcuma longa: Evaluation of its antibacterial properties against oral pathogens
- Development of AMBER-compliant transferable force field parameters for polytetrafluoroethylene
- Treatment of gestational diabetes by Acroptilon repens leaf aqueous extract green-formulated iron nanoparticles in rats
- Development and characterization of new ecological adsorbents based on cardoon wastes: Application to brilliant green adsorption
- A fast, sensitive, greener, and stability-indicating HPLC method for the standardization and quantitative determination of chlorhexidine acetate in commercial products
- Assessment of Se, As, Cd, Cr, Hg, and Pb content status in Ankang tea plantations of China
- Effect of transition metal chloride (ZnCl2) on low-temperature pyrolysis of high ash bituminous coal
- Evaluating polyphenol and ascorbic acid contents, tannin removal ability, and physical properties during hydrolysis and convective hot-air drying of cashew apple powder
- Development and characterization of functional low-fat frozen dairy dessert enhanced with dried lemongrass powder
- Scrutinizing the effect of additive and synergistic antibiotics against carbapenem-resistant Pseudomonas aeruginosa
- Preparation, characterization, and determination of the therapeutic effects of copper nanoparticles green-formulated by Pistacia atlantica in diabetes-induced cardiac dysfunction in rat
- Antioxidant and antidiabetic potentials of methoxy-substituted Schiff bases using in vitro, in vivo, and molecular simulation approaches
- Anti-melanoma cancer activity and chemical profile of the essential oil of Seseli yunnanense Franch
- Molecular docking analysis of subtilisin-like alkaline serine protease (SLASP) and laccase with natural biopolymers
- Overcoming methicillin resistance by methicillin-resistant Staphylococcus aureus: Computational evaluation of napthyridine and oxadiazoles compounds for potential dual inhibition of PBP-2a and FemA proteins
- Exploring novel antitubercular agents: Innovative design of 2,3-diaryl-quinoxalines targeting DprE1 for effective tuberculosis treatment
- Drimia maritima flowers as a source of biologically potent components: Optimization of bioactive compound extractions, isolation, UPLC–ESI–MS/MS, and pharmacological properties
- Estimating molecular properties, drug-likeness, cardiotoxic risk, liability profile, and molecular docking study to characterize binding process of key phyto-compounds against serotonin 5-HT2A receptor
- Fabrication of β-cyclodextrin-based microgels for enhancing solubility of Terbinafine: An in-vitro and in-vivo toxicological evaluation
- Phyto-mediated synthesis of ZnO nanoparticles and their sunlight-driven photocatalytic degradation of cationic and anionic dyes
- Monosodium glutamate induces hypothalamic–pituitary–adrenal axis hyperactivation, glucocorticoid receptors down-regulation, and systemic inflammatory response in young male rats: Impact on miR-155 and miR-218
- Quality control analyses of selected honey samples from Serbia based on their mineral and flavonoid profiles, and the invertase activity
- Eco-friendly synthesis of silver nanoparticles using Phyllanthus niruri leaf extract: Assessment of antimicrobial activity, effectiveness on tropical neglected mosquito vector control, and biocompatibility using a fibroblast cell line model
- Green synthesis of silver nanoparticles containing Cichorium intybus to treat the sepsis-induced DNA damage in the liver of Wistar albino rats
- Quality changes of durian pulp (Durio ziberhinus Murr.) in cold storage
- Study on recrystallization process of nitroguanidine by directly adding cold water to control temperature
- Determination of heavy metals and health risk assessment in drinking water in Bukayriyah City, Saudi Arabia
- Larvicidal properties of essential oils of three Artemisia species against the chemically insecticide-resistant Nile fever vector Culex pipiens (L.) (Diptera: Culicidae): In vitro and in silico studies
- Design, synthesis, characterization, and theoretical calculations, along with in silico and in vitro antimicrobial proprieties of new isoxazole-amide conjugates
- The impact of drying and extraction methods on total lipid, fatty acid profile, and cytotoxicity of Tenebrio molitor larvae
- A zinc oxide–tin oxide–nerolidol hybrid nanomaterial: Efficacy against esophageal squamous cell carcinoma
- Research on technological process for production of muskmelon juice (Cucumis melo L.)
- Physicochemical components, antioxidant activity, and predictive models for quality of soursop tea (Annona muricata L.) during heat pump drying
- Characterization and application of Fe1−xCoxFe2O4 nanoparticles in Direct Red 79 adsorption
- Torilis arvensis ethanolic extract: Phytochemical analysis, antifungal efficacy, and cytotoxicity properties
- Magnetite–poly-1H pyrrole dendritic nanocomposite seeded on poly-1H pyrrole: A promising photocathode for green hydrogen generation from sanitation water without using external sacrificing agent
- HPLC and GC–MS analyses of phytochemical compounds in Haloxylon salicornicum extract: Antibacterial and antifungal activity assessment of phytopathogens
- Efficient and stable to coking catalysts of ethanol steam reforming comprised of Ni + Ru loaded on MgAl2O4 + LnFe0.7Ni0.3O3 (Ln = La, Pr) nanocomposites prepared via cost-effective procedure with Pluronic P123 copolymer
- Nitrogen and boron co-doped carbon dots probe for selectively detecting Hg2+ in water samples and the detection mechanism
- Heavy metals in road dust from typical old industrial areas of Wuhan: Seasonal distribution and bioaccessibility-based health risk assessment
- Phytochemical profiling and bioactivity evaluation of CBD- and THC-enriched Cannabis sativa extracts: In vitro and in silico investigation of antioxidant and anti-inflammatory effects
- Investigating dye adsorption: The role of surface-modified montmorillonite nanoclay in kinetics, isotherms, and thermodynamics
- Antimicrobial activity, induction of ROS generation in HepG2 liver cancer cells, and chemical composition of Pterospermum heterophyllum
- Study on the performance of nanoparticle-modified PVDF membrane in delaying membrane aging
- Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes
- Review Articles
- Structural aspects of Pt(η3-X1N1X2)(PL) (X1,2 = O, C, or Se) and Pt(η3-N1N2X1)(PL) (X1 = C, S, or Se) derivatives
- Biosurfactants in biocorrosion and corrosion mitigation of metals: An overview
- Stimulus-responsive MOF–hydrogel composites: Classification, preparation, characterization, and their advancement in medical treatments
- Electrochemical dissolution of titanium under alternating current polarization to obtain its dioxide
- Special Issue on Recent Trends in Green Chemistry
- Phytochemical screening and antioxidant activity of Vitex agnus-castus L.
- Phytochemical study, antioxidant activity, and dermoprotective activity of Chenopodium ambrosioides (L.)
- Exploitation of mangliculous marine fungi, Amarenographium solium, for the green synthesis of silver nanoparticles and their activity against multiple drug-resistant bacteria
- Study of the phytotoxicity of margines on Pistia stratiotes L.
- Special Issue on Advanced Nanomaterials for Energy, Environmental and Biological Applications - Part III
- Impact of biogenic zinc oxide nanoparticles on growth, development, and antioxidant system of high protein content crop (Lablab purpureus L.) sweet
- Green synthesis, characterization, and application of iron and molybdenum nanoparticles and their composites for enhancing the growth of Solanum lycopersicum
- Green synthesis of silver nanoparticles from Olea europaea L. extracted polysaccharides, characterization, and its assessment as an antimicrobial agent against multiple pathogenic microbes
- Photocatalytic treatment of organic dyes using metal oxides and nanocomposites: A quantitative study
- Antifungal, antioxidant, and photocatalytic activities of greenly synthesized iron oxide nanoparticles
- Special Issue on Phytochemical and Pharmacological Scrutinization of Medicinal Plants
- Hepatoprotective effects of safranal on acetaminophen-induced hepatotoxicity in rats
- Chemical composition and biological properties of Thymus capitatus plants from Algerian high plains: A comparative and analytical study
- Chemical composition and bioactivities of the methanol root extracts of Saussurea costus
- In vivo protective effects of vitamin C against cyto-genotoxicity induced by Dysphania ambrosioides aqueous extract
- Insights about the deleterious impact of a carbamate pesticide on some metabolic immune and antioxidant functions and a focus on the protective ability of a Saharan shrub and its anti-edematous property
- A comprehensive review uncovering the anticancerous potential of genkwanin (plant-derived compound) in several human carcinomas
- A study to investigate the anticancer potential of carvacrol via targeting Notch signaling in breast cancer
- Assessment of anti-diabetic properties of Ziziphus oenopolia (L.) wild edible fruit extract: In vitro and in silico investigations through molecular docking analysis
- Optimization of polyphenol extraction, phenolic profile by LC-ESI-MS/MS, antioxidant, anti-enzymatic, and cytotoxic activities of Physalis acutifolia
- Phytochemical screening, antioxidant properties, and photo-protective activities of Salvia balansae de Noé ex Coss
- Antihyperglycemic, antiglycation, anti-hypercholesteremic, and toxicity evaluation with gas chromatography mass spectrometry profiling for Aloe armatissima leaves
- Phyto-fabrication and characterization of gold nanoparticles by using Timur (Zanthoxylum armatum DC) and their effect on wound healing
- Does Erodium trifolium (Cav.) Guitt exhibit medicinal properties? Response elements from phytochemical profiling, enzyme-inhibiting, and antioxidant and antimicrobial activities
- Integrative in silico evaluation of the antiviral potential of terpenoids and its metal complexes derived from Homalomena aromatica based on main protease of SARS-CoV-2
- 6-Methoxyflavone improves anxiety, depression, and memory by increasing monoamines in mice brain: HPLC analysis and in silico studies
- Simultaneous extraction and quantification of hydrophilic and lipophilic antioxidants in Solanum lycopersicum L. varieties marketed in Saudi Arabia
- Biological evaluation of CH3OH and C2H5OH of Berberis vulgaris for in vivo antileishmanial potential against Leishmania tropica in murine models
Artikel in diesem Heft
- Regular Articles
- Porous silicon nanostructures: Synthesis, characterization, and their antifungal activity
- Biochar from de-oiled Chlorella vulgaris and its adsorption on antibiotics
- Phytochemicals profiling, in vitro and in vivo antidiabetic activity, and in silico studies on Ajuga iva (L.) Schreb.: A comprehensive approach
- Synthesis, characterization, in silico and in vitro studies of novel glycoconjugates as potential antibacterial, antifungal, and antileishmanial agents
- Sonochemical synthesis of gold nanoparticles mediated by potato starch: Its performance in the treatment of esophageal cancer
- Computational study of ADME-Tox prediction of selected phytochemicals from Punica granatum peels
- Phytochemical analysis, in vitro antioxidant and antifungal activities of extracts and essential oil derived from Artemisia herba-alba Asso
- Two triazole-based coordination polymers: Synthesis and crystal structure characterization
- Phytochemical and physicochemical studies of different apple varieties grown in Morocco
- Synthesis of multi-template molecularly imprinted polymers (MT-MIPs) for isolating ethyl para-methoxycinnamate and ethyl cinnamate from Kaempferia galanga L., extract with methacrylic acid as functional monomer
- Nutraceutical potential of Mesembryanthemum forsskaolii Hochst. ex Bioss.: Insights into its nutritional composition, phytochemical contents, and antioxidant activity
- Evaluation of influence of Butea monosperma floral extract on inflammatory biomarkers
- Cannabis sativa L. essential oil: Chemical composition, anti-oxidant, anti-microbial properties, and acute toxicity: In vitro, in vivo, and in silico study
- The effect of gamma radiation on 5-hydroxymethylfurfural conversion in water and dimethyl sulfoxide
- Hollow mushroom nanomaterials for potentiometric sensing of Pb2+ ions in water via the intercalation of iodide ions into the polypyrrole matrix
- Determination of essential oil and chemical composition of St. John’s Wort
- Computational design and in vitro assay of lantadene-based novel inhibitors of NS3 protease of dengue virus
- Anti-parasitic activity and computational studies on a novel labdane diterpene from the roots of Vachellia nilotica
- Microbial dynamics and dehydrogenase activity in tomato (Lycopersicon esculentum Mill.) rhizospheres: Impacts on growth and soil health across different soil types
- Correlation between in vitro anti-urease activity and in silico molecular modeling approach of novel imidazopyridine–oxadiazole hybrids derivatives
- Spatial mapping of indoor air quality in a light metro system using the geographic information system method
- Iron indices and hemogram in renal anemia and the improvement with Tribulus terrestris green-formulated silver nanoparticles applied on rat model
- Integrated track of nano-informatics coupling with the enrichment concept in developing a novel nanoparticle targeting ERK protein in Naegleria fowleri
- Cytotoxic and phytochemical screening of Solanum lycopersicum–Daucus carota hydro-ethanolic extract and in silico evaluation of its lycopene content as anticancer agent
- Protective activities of silver nanoparticles containing Panax japonicus on apoptotic, inflammatory, and oxidative alterations in isoproterenol-induced cardiotoxicity
- pH-based colorimetric detection of monofunctional aldehydes in liquid and gas phases
- Investigating the effect of resveratrol on apoptosis and regulation of gene expression of Caco-2 cells: Unravelling potential implications for colorectal cancer treatment
- Metformin inhibits knee osteoarthritis induced by type 2 diabetes mellitus in rats: S100A8/9 and S100A12 as players and therapeutic targets
- Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized rats
- Synthesis of new analogs of N-substituted(benzoylamino)-1,2,3,6-tetrahydropyridines
- Response of yield and quality of Japonica rice to different gradients of moisture deficit at grain-filling stage in cold regions
- Preparation of an inclusion complex of nickel-based β-cyclodextrin: Characterization and accelerating the osteoarthritis articular cartilage repair
- Empagliflozin-loaded nanomicelles responsive to reactive oxygen species for renal ischemia/reperfusion injury protection
- Preparation and pharmacodynamic evaluation of sodium aescinate solid lipid nanoparticles
- Assessment of potentially toxic elements and health risks of agricultural soil in Southwest Riyadh, Saudi Arabia
- Theoretical investigation of hydrogen-rich fuel production through ammonia decomposition
- Biosynthesis and screening of cobalt nanoparticles using citrus species for antimicrobial activity
- Investigating the interplay of genetic variations, MCP-1 polymorphism, and docking with phytochemical inhibitors for combatting dengue virus pathogenicity through in silico analysis
- Ultrasound induced biosynthesis of silver nanoparticles embedded into chitosan polymers: Investigation of its anti-cutaneous squamous cell carcinoma effects
- Copper oxide nanoparticles-mediated Heliotropium bacciferum leaf extract: Antifungal activity and molecular docking assays against strawberry pathogens
- Sprouted wheat flour for improving physical, chemical, rheological, microbial load, and quality properties of fino bread
- Comparative toxicity assessment of fisetin-aided artificial intelligence-assisted drug design targeting epibulbar dermoid through phytochemicals
- Acute toxicity and anti-inflammatory activity of bis-thiourea derivatives
- Anti-diabetic activity-guided isolation of α-amylase and α-glucosidase inhibitory terpenes from Capsella bursa-pastoris Linn.
- GC–MS analysis of Lactobacillus plantarum YW11 metabolites and its computational analysis on familial pulmonary fibrosis hub genes
- Green formulation of copper nanoparticles by Pistacia khinjuk leaf aqueous extract: Introducing a novel chemotherapeutic drug for the treatment of prostate cancer
- Improved photocatalytic properties of WO3 nanoparticles for Malachite green dye degradation under visible light irradiation: An effect of La doping
- One-pot synthesis of a network of Mn2O3–MnO2–poly(m-methylaniline) composite nanorods on a polypyrrole film presents a promising and efficient optoelectronic and solar cell device
- Groundwater quality and health risk assessment of nitrate and fluoride in Al Qaseem area, Saudi Arabia
- A comparative study of the antifungal efficacy and phytochemical composition of date palm leaflet extracts
- Processing of alcohol pomelo beverage (Citrus grandis (L.) Osbeck) using saccharomyces yeast: Optimization, physicochemical quality, and sensory characteristics
- Specialized compounds of four Cameroonian spices: Isolation, characterization, and in silico evaluation as prospective SARS-CoV-2 inhibitors
- Identification of a novel drug target in Porphyromonas gingivalis by a computational genome analysis approach
- Physico-chemical properties and durability of a fly-ash-based geopolymer
- FMS-like tyrosine kinase 3 inhibitory potentials of some phytochemicals from anti-leukemic plants using computational chemical methodologies
- Wild Thymus zygis L. ssp. gracilis and Eucalyptus camaldulensis Dehnh.: Chemical composition, antioxidant and antibacterial activities of essential oils
- 3D-QSAR, molecular docking, ADMET, simulation dynamic, and retrosynthesis studies on new styrylquinolines derivatives against breast cancer
- Deciphering the influenza neuraminidase inhibitory potential of naturally occurring biflavonoids: An in silico approach
- Determination of heavy elements in agricultural regions, Saudi Arabia
- Synthesis and characterization of antioxidant-enriched Moringa oil-based edible oleogel
- Ameliorative effects of thistle and thyme honeys on cyclophosphamide-induced toxicity in mice
- Study of phytochemical compound and antipyretic activity of Chenopodium ambrosioides L. fractions
- Investigating the adsorption mechanism of zinc chloride-modified porous carbon for sulfadiazine removal from water
- Performance repair of building materials using alumina and silica composite nanomaterials with electrodynamic properties
- Effects of nanoparticles on the activity and resistance genes of anaerobic digestion enzymes in livestock and poultry manure containing the antibiotic tetracycline
- Effect of copper nanoparticles green-synthesized using Ocimum basilicum against Pseudomonas aeruginosa in mice lung infection model
- Cardioprotective effects of nanoparticles green formulated by Spinacia oleracea extract on isoproterenol-induced myocardial infarction in mice by the determination of PPAR-γ/NF-κB pathway
- Anti-OTC antibody-conjugated fluorescent magnetic/silica and fluorescent hybrid silica nanoparticles for oxytetracycline detection
- Curcumin conjugated zinc nanoparticles for the treatment of myocardial infarction
- Identification and in silico screening of natural phloroglucinols as potential PI3Kα inhibitors: A computational approach for drug discovery
- Exploring the phytochemical profile and antioxidant evaluation: Molecular docking and ADMET analysis of main compounds from three Solanum species in Saudi Arabia
- Unveiling the molecular composition and biological properties of essential oil derived from the leaves of wild Mentha aquatica L.: A comprehensive in vitro and in silico exploration
- Analysis of bioactive compounds present in Boerhavia elegans seeds by GC-MS
- Homology modeling and molecular docking study of corticotrophin-releasing hormone: An approach to treat stress-related diseases
- LncRNA MIR17HG alleviates heart failure via targeting MIR17HG/miR-153-3p/SIRT1 axis in in vitro model
- Development and validation of a stability indicating UPLC-DAD method coupled with MS-TQD for ramipril and thymoquinone in bioactive SNEDDS with in silico toxicity analysis of ramipril degradation products
- Biosynthesis of Ag/Cu nanocomposite mediated by Curcuma longa: Evaluation of its antibacterial properties against oral pathogens
- Development of AMBER-compliant transferable force field parameters for polytetrafluoroethylene
- Treatment of gestational diabetes by Acroptilon repens leaf aqueous extract green-formulated iron nanoparticles in rats
- Development and characterization of new ecological adsorbents based on cardoon wastes: Application to brilliant green adsorption
- A fast, sensitive, greener, and stability-indicating HPLC method for the standardization and quantitative determination of chlorhexidine acetate in commercial products
- Assessment of Se, As, Cd, Cr, Hg, and Pb content status in Ankang tea plantations of China
- Effect of transition metal chloride (ZnCl2) on low-temperature pyrolysis of high ash bituminous coal
- Evaluating polyphenol and ascorbic acid contents, tannin removal ability, and physical properties during hydrolysis and convective hot-air drying of cashew apple powder
- Development and characterization of functional low-fat frozen dairy dessert enhanced with dried lemongrass powder
- Scrutinizing the effect of additive and synergistic antibiotics against carbapenem-resistant Pseudomonas aeruginosa
- Preparation, characterization, and determination of the therapeutic effects of copper nanoparticles green-formulated by Pistacia atlantica in diabetes-induced cardiac dysfunction in rat
- Antioxidant and antidiabetic potentials of methoxy-substituted Schiff bases using in vitro, in vivo, and molecular simulation approaches
- Anti-melanoma cancer activity and chemical profile of the essential oil of Seseli yunnanense Franch
- Molecular docking analysis of subtilisin-like alkaline serine protease (SLASP) and laccase with natural biopolymers
- Overcoming methicillin resistance by methicillin-resistant Staphylococcus aureus: Computational evaluation of napthyridine and oxadiazoles compounds for potential dual inhibition of PBP-2a and FemA proteins
- Exploring novel antitubercular agents: Innovative design of 2,3-diaryl-quinoxalines targeting DprE1 for effective tuberculosis treatment
- Drimia maritima flowers as a source of biologically potent components: Optimization of bioactive compound extractions, isolation, UPLC–ESI–MS/MS, and pharmacological properties
- Estimating molecular properties, drug-likeness, cardiotoxic risk, liability profile, and molecular docking study to characterize binding process of key phyto-compounds against serotonin 5-HT2A receptor
- Fabrication of β-cyclodextrin-based microgels for enhancing solubility of Terbinafine: An in-vitro and in-vivo toxicological evaluation
- Phyto-mediated synthesis of ZnO nanoparticles and their sunlight-driven photocatalytic degradation of cationic and anionic dyes
- Monosodium glutamate induces hypothalamic–pituitary–adrenal axis hyperactivation, glucocorticoid receptors down-regulation, and systemic inflammatory response in young male rats: Impact on miR-155 and miR-218
- Quality control analyses of selected honey samples from Serbia based on their mineral and flavonoid profiles, and the invertase activity
- Eco-friendly synthesis of silver nanoparticles using Phyllanthus niruri leaf extract: Assessment of antimicrobial activity, effectiveness on tropical neglected mosquito vector control, and biocompatibility using a fibroblast cell line model
- Green synthesis of silver nanoparticles containing Cichorium intybus to treat the sepsis-induced DNA damage in the liver of Wistar albino rats
- Quality changes of durian pulp (Durio ziberhinus Murr.) in cold storage
- Study on recrystallization process of nitroguanidine by directly adding cold water to control temperature
- Determination of heavy metals and health risk assessment in drinking water in Bukayriyah City, Saudi Arabia
- Larvicidal properties of essential oils of three Artemisia species against the chemically insecticide-resistant Nile fever vector Culex pipiens (L.) (Diptera: Culicidae): In vitro and in silico studies
- Design, synthesis, characterization, and theoretical calculations, along with in silico and in vitro antimicrobial proprieties of new isoxazole-amide conjugates
- The impact of drying and extraction methods on total lipid, fatty acid profile, and cytotoxicity of Tenebrio molitor larvae
- A zinc oxide–tin oxide–nerolidol hybrid nanomaterial: Efficacy against esophageal squamous cell carcinoma
- Research on technological process for production of muskmelon juice (Cucumis melo L.)
- Physicochemical components, antioxidant activity, and predictive models for quality of soursop tea (Annona muricata L.) during heat pump drying
- Characterization and application of Fe1−xCoxFe2O4 nanoparticles in Direct Red 79 adsorption
- Torilis arvensis ethanolic extract: Phytochemical analysis, antifungal efficacy, and cytotoxicity properties
- Magnetite–poly-1H pyrrole dendritic nanocomposite seeded on poly-1H pyrrole: A promising photocathode for green hydrogen generation from sanitation water without using external sacrificing agent
- HPLC and GC–MS analyses of phytochemical compounds in Haloxylon salicornicum extract: Antibacterial and antifungal activity assessment of phytopathogens
- Efficient and stable to coking catalysts of ethanol steam reforming comprised of Ni + Ru loaded on MgAl2O4 + LnFe0.7Ni0.3O3 (Ln = La, Pr) nanocomposites prepared via cost-effective procedure with Pluronic P123 copolymer
- Nitrogen and boron co-doped carbon dots probe for selectively detecting Hg2+ in water samples and the detection mechanism
- Heavy metals in road dust from typical old industrial areas of Wuhan: Seasonal distribution and bioaccessibility-based health risk assessment
- Phytochemical profiling and bioactivity evaluation of CBD- and THC-enriched Cannabis sativa extracts: In vitro and in silico investigation of antioxidant and anti-inflammatory effects
- Investigating dye adsorption: The role of surface-modified montmorillonite nanoclay in kinetics, isotherms, and thermodynamics
- Antimicrobial activity, induction of ROS generation in HepG2 liver cancer cells, and chemical composition of Pterospermum heterophyllum
- Study on the performance of nanoparticle-modified PVDF membrane in delaying membrane aging
- Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes
- Review Articles
- Structural aspects of Pt(η3-X1N1X2)(PL) (X1,2 = O, C, or Se) and Pt(η3-N1N2X1)(PL) (X1 = C, S, or Se) derivatives
- Biosurfactants in biocorrosion and corrosion mitigation of metals: An overview
- Stimulus-responsive MOF–hydrogel composites: Classification, preparation, characterization, and their advancement in medical treatments
- Electrochemical dissolution of titanium under alternating current polarization to obtain its dioxide
- Special Issue on Recent Trends in Green Chemistry
- Phytochemical screening and antioxidant activity of Vitex agnus-castus L.
- Phytochemical study, antioxidant activity, and dermoprotective activity of Chenopodium ambrosioides (L.)
- Exploitation of mangliculous marine fungi, Amarenographium solium, for the green synthesis of silver nanoparticles and their activity against multiple drug-resistant bacteria
- Study of the phytotoxicity of margines on Pistia stratiotes L.
- Special Issue on Advanced Nanomaterials for Energy, Environmental and Biological Applications - Part III
- Impact of biogenic zinc oxide nanoparticles on growth, development, and antioxidant system of high protein content crop (Lablab purpureus L.) sweet
- Green synthesis, characterization, and application of iron and molybdenum nanoparticles and their composites for enhancing the growth of Solanum lycopersicum
- Green synthesis of silver nanoparticles from Olea europaea L. extracted polysaccharides, characterization, and its assessment as an antimicrobial agent against multiple pathogenic microbes
- Photocatalytic treatment of organic dyes using metal oxides and nanocomposites: A quantitative study
- Antifungal, antioxidant, and photocatalytic activities of greenly synthesized iron oxide nanoparticles
- Special Issue on Phytochemical and Pharmacological Scrutinization of Medicinal Plants
- Hepatoprotective effects of safranal on acetaminophen-induced hepatotoxicity in rats
- Chemical composition and biological properties of Thymus capitatus plants from Algerian high plains: A comparative and analytical study
- Chemical composition and bioactivities of the methanol root extracts of Saussurea costus
- In vivo protective effects of vitamin C against cyto-genotoxicity induced by Dysphania ambrosioides aqueous extract
- Insights about the deleterious impact of a carbamate pesticide on some metabolic immune and antioxidant functions and a focus on the protective ability of a Saharan shrub and its anti-edematous property
- A comprehensive review uncovering the anticancerous potential of genkwanin (plant-derived compound) in several human carcinomas
- A study to investigate the anticancer potential of carvacrol via targeting Notch signaling in breast cancer
- Assessment of anti-diabetic properties of Ziziphus oenopolia (L.) wild edible fruit extract: In vitro and in silico investigations through molecular docking analysis
- Optimization of polyphenol extraction, phenolic profile by LC-ESI-MS/MS, antioxidant, anti-enzymatic, and cytotoxic activities of Physalis acutifolia
- Phytochemical screening, antioxidant properties, and photo-protective activities of Salvia balansae de Noé ex Coss
- Antihyperglycemic, antiglycation, anti-hypercholesteremic, and toxicity evaluation with gas chromatography mass spectrometry profiling for Aloe armatissima leaves
- Phyto-fabrication and characterization of gold nanoparticles by using Timur (Zanthoxylum armatum DC) and their effect on wound healing
- Does Erodium trifolium (Cav.) Guitt exhibit medicinal properties? Response elements from phytochemical profiling, enzyme-inhibiting, and antioxidant and antimicrobial activities
- Integrative in silico evaluation of the antiviral potential of terpenoids and its metal complexes derived from Homalomena aromatica based on main protease of SARS-CoV-2
- 6-Methoxyflavone improves anxiety, depression, and memory by increasing monoamines in mice brain: HPLC analysis and in silico studies
- Simultaneous extraction and quantification of hydrophilic and lipophilic antioxidants in Solanum lycopersicum L. varieties marketed in Saudi Arabia
- Biological evaluation of CH3OH and C2H5OH of Berberis vulgaris for in vivo antileishmanial potential against Leishmania tropica in murine models