Home Physical Sciences Green synthesis of silver nanoparticles containing Cichorium intybus to treat the sepsis-induced DNA damage in the liver of Wistar albino rats
Article Open Access

Green synthesis of silver nanoparticles containing Cichorium intybus to treat the sepsis-induced DNA damage in the liver of Wistar albino rats

  • Yang Liu , Zhiyun Liu , Tejin Ba , Shuanglin Zhang , Bagenna Bao , Haibo Mu , Li Kong and Feihu Zhang EMAIL logo
Published/Copyright: October 28, 2024
Download Article (PDF)
Open Chemistry
From the journal Open Chemistry Volume 22 Issue 1

Abstract

Sepsis is a severe reaction of the body to an infection, presenting a critical medical crisis. It represents an imbalance between the body’s anti- and pro-inflammatory reactions. The occurrence of sepsis, which leads to multiple-organ failure and increased mortality, is marked by dysfunction in the lungs, heart, kidneys, and liver. The involvement of reactive oxygen species is believed to contribute to the progression of sepsis. Data suggest potential advantages of phenolic compounds derived from plants in combating sepsis. Plant polyphenols can be antioxidants by scavenging free radicals, chelating metals, and binding to proteins. In this research, silver nanoparticles (AgNPs) were produced by the aqueous extract of Cichorium intybus leaf for the purpose of treating sepsis-induced DNA harm. The recent study focused on the biological aspect including the cytotoxicity properties on normal (HUVEC) cell line. The AgNPs were analyzed by transmission electron microscopy (TEM), scanning electron microscopy (SEM), fourier-transform infrared spectroscopy, X-ray powder diffraction, and UV-Vis. The TEM and SEM images of AgNPs exhibited the average size of 35.29 nm with spherical morphology. In the in vivo study, the animals were categorized into four groups: sepsis-induced, sham, AgNPs-20, and AgNPs-100. AgNPs treatment resulted in a significant decrease in tissues damage (p < 0.01). The sepsis-induced group showed a significantly elevated malondialdehyde (MDA) level in comparison to the sham group (p < 0.01). Nevertheless, the groups that received AgNPs experienced a decrease in MDA levels and an increase in glutathione and superoxide dismutases levels (p < 0.01). Additionally, the rats treated with AgNPs exhibited a reduction in the IL-1β mRNA expression levels (p < 0.01).

Keywords: Cichorium intybus ; cytotoxicity; sepsis-induced DNA damage; silver ‎ nanoparticles

1 Introduction

Sepsis, a primary contributor to worldwide mortality rates, develops as a consequence of the body’s immune reaction to an infection, leading to severe organ failure. The prognosis for sepsis is serious. Approximately 30% of those who survive may experience prolonged dysfunction and cognitive impairment, resulting in a significant societal and personal burden [1,2,3]. The guidelines for managing sepsis emphasize three key elements: regulating the body’s response to sepsis, controlling infections, and maintaining hemodynamic stability. Additional interventions encompass organ support measures that are not specific, such as implementing renal replacement therapy, administering corticosteroids, providing hemodynamic support, utilizing mechanical ventilation, and administering oxygen therapy [2,3,4]. Sepsis management frequently relies on a multimodal approach tailored to the severity of the condition. In cases of mild single-organ dysfunction, appropriate support measures are usually sufficient, whereas multiple-organ dysfunction may necessitate more aggressive, invasive treatments. Antibiotic therapies are the established norm in clinical protocols for sepsis [3,4]. Nevertheless, a significant majority of sepsis fatalities, approximately 70–80%, can be attributed to enduring infections, highlighting the prevalent issue of antibiotic resistance and the insufficiency of potent antibiotics. Furthermore, despite the prompt administration of antibiotics being highly effective, the immune response of the host to sepsis can initiate the widespread release of reactive oxygen species (ROS), diverse cytokines, and other biomolecules [4]. This overwhelming reaction can swiftly fail multiple organs and ultimately lead to mortality. New clinical evidence has revealed that even though over 60% of individuals with sepsis manage to survive the initial inflammatory response, they subsequently experience a prolonged period of immunosuppression [3,4]. This state is marked by paralysis and the death of immune cells, which hampers their ability to eliminate invasive pathogens. Consequently, patients become more susceptible to hospital-acquired infections and face a higher risk of mortality. As a result, researchers are currently investigating novel adjuvant treatments, including antioxidants, immunomodulators, and anti-inflammatory agents [3,4,5]. Nevertheless, numerous antioxidants and anti-inflammatory substances face limitations such as brief duration of action, inability to specifically target certain cells or tissues, and inadequate solubility in water along with low bioavailability [2,4]. Furthermore, due to cellular enzyme actions, certain peptides exhibited notable anti-inflammatory properties in laboratory studies, yet failed to demonstrate the same impact in live organisms. Moreover, the intricate pathophysiology associated with multi-channel cytokine storms necessitates a comprehensive strategy, as a single-drug method may prove ineffective [3,4].

Nanotechnology has provided a new avenue for addressing the significant challenges posed by drug resistance and adverse effects. By utilizing natural or synthetic materials as carriers, drugs can be introduced by different methods within a drug-delivery nanosystem. Additionally, nanotechnology may encompass nano-drug crystals which are responsible for the direct processing of raw drugs [5,6]. Traditional methods for synthesizing silver nanoparticles (AgNPs) often require extreme conditions, incur significant expenses, and contribute to environmental contamination. In this regard, researchers are diligently exploring sustainable and environmentally friendly alternatives to traditional chemical synthesis techniques [5,6,7]. This has resulted in the advancement of environmentally friendly formulation ways, particularly highlighting the significant progress made in the herb-mediated formulation of AgNPs. Particularly noteworthy is the ability of plant extracts to function as stabilizing and reducing agents [7,8,9]. This capability paves the way for innovative approaches to cost-effective and environmentally sustainable nanoparticle (NP) synthesis, resulting in improved stability and size uniformity [7,8]. Additionally, AgNPs inspired by biological systems and sourced from plants demonstrate fascinating pharmacological characteristics, rendering them exceptionally promising for medical applications owing to their nanoscale dimensions and biocompatibility [7,8,9,10]. Bioengineered NPs sourced from natural materials signify an innovative advancement in the fight against several diseases [11,12]. The research highlights their exceptional antimicrobial effectiveness and diverse mechanisms of action [12]. The outlook for the future is promising, presenting opportunities for cost efficiency and scalability via sustainable synthesis techniques. Nevertheless, it is essential to tackle issues related to regulatory challenges, toxicity, and environmental factors [11,12].

Most nanocarriers lack any specific function (although certain unique nanocarriers may exhibit internal activities like photothermal performance, antioxidant performance, etc.) [5,6]. On the other hand, drugs possess surface and nano-size characteristics as they enter a novel system, thereby altering their metabolic and distribution pathway. Consequently, this alteration leads to a distinct drug effect compared to raw drugs [5]. The proper physical and chemical properties of nanotechnology, including shape, surface chemistry, charge, size, etc., along with their potential surface functionalization, contribute to their significant potential in accurately treating sepsis [5,6,7]. For instance, particles with a size between 0.5 and 5 μm demonstrate superb pulmonary-targeting capabilities due to their potential to get caught in pulmonary capillaries [6,7,8,9]. Nanosystems for drug delivery can be engineered with particle sizes that are smaller than the fenestrations of the endothelium, allowing for precise targeting of the renal tubule. This is necessary because nanocarriers must navigate through endothelial fenestrations anatomical barriers and become lodged in the space between the glomerular basement membrane and endothelial fenestrations [5,6,10,11]. In preclinical models, the efficacy of various silver systems in managing sepsis and septic shock has been demonstrated, showcasing their remarkable treatment effects [9,10,11]. AgNP systems, acting as antibacterial agents, can serve as bases engaging with inflammatory cells to rebalance homeostasis, immobilize endotoxin adsorbents, and promptly identify sepsis biomarkers [10,11]. Various NP platforms are suggested as potential vehicles for anti-sepsis treatments because of the distinctive characteristics of NPs, including their pharmacokinetic/biodistribution profiles, surface functionalization, and small size [13,14]. NP systems can undergo surface modifications and form conjugates with different molecules on their surface. This modification allows for an extended circulation time within the body, as it prevents removal by immune cells. Moreover, it enables the targeted delivery of drug-loaded substances to specific cells, proteins, and inflammatory sites, thus enhancing therapeutic efficacy [15,16].

The Cichorium intybus leaf aqueous extract was utilized in this study to formulate AgNPs, with the aim of addressing damages induced by sepsis in several tissues of animals. The primary focus of this recent investigation was on the biological aspect, wherein the cells treated with NPs were subjected to the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay for 48 h to assess their cytotoxic properties on normal (HUVEC) cell lines. The formulated AgNPs were subjected to characterization by various analytical tests, including X-ray powder diffraction (XRD), scanning electron microscopy (SEM), ultraviolet–visible spectrophotometry (UV-Vis), transmission electron microscopy (TEM), and fourier-transform infrared spectroscopy (FT-IR).

2 Experimental

2.1 Preparation of plant extract

The freshly gathered leaves of C. intybus were washed to remove any contaminants and dirt, and subsequently dried in the shade to prepare them for powdering. Then, 30 g of powdered material were introduced into a 0.3 L conical flask, accompanied by 0.2 L of water. The mixture was then heated by a magnetic stirrer. Subsequently, the solution was filtered by the Whatman filter paper, and the extract from the leaves was employed in the AgNPs synthesis [17].

2.2 Green synthesis of NPs

AgNPs were prepared using AgNO3 through extraction. To formulate AgNPs, AgNO3 (1 mM) solution was added to the C. intybus extract. The resulting mixture of the AgNO3 and extract was then stored in a dark place at 25°C. This allowed the conversion of Ag to Ag+ to occur. Next, to acquire AgNPs, the solution that contains AgNPs was centrifuged for 0.5 h at 4,000 rpm. The solution present in the upper part of the tube was discarded, while the AgNPs settled at the bottom of the tube were mixed with water and subjected to centrifugation once again.

2.3 Chemical characterization

For the FT-IR measurement, approximately 3 mg of AgNPs was thoroughly blended with 0.098 g of potassium bromide using a pestle and mortar. Additionally, the well-blended powder was processed through a pellet-making machine to produce a pellet. Ultimately, the pellet was positioned alongside a blank KBr pellet for measuring at 400–4,000 cm−1. UV-visible spectroscopy was employed to monitor the bio-depletion of Ag ions in an aqueous solution. The investigation of UV-Vis spectroscopy was conducted over a wavelength range of 200 to 800 nm. In cases where the color was darker, 2 mL of double distilled water was mixed with the collected samples before the scanning process commenced. Approximately 4–5 mg of AgNPs was applied using a brush onto the double-sided carbon-coated tape, which was subsequently affixed to an aluminum stub for the FE-SEM image. Ultimately, the sample mounted on the aluminum stub was positioned in the FE-SEM sample holder, where images were captured at various resolutions using an operating current of 20 kV extra high tension and a working distance of 8.5 mm. The crystallographic arrangement of AgNPs and the identification of their phases were established through the analysis of XRD patterns. The AgNPs sample underwent analysis within the 2θ degree range of 0°–80°, utilizing a step width of 0.02 and a scanning speed of 10.00° per minute. The most recent measurement recorded was 50 mA. The thoroughly dried AgNPs powder was placed in the sample holder, after which the spectra were collected.

2.4 MTT assay

In this study, after culturing 105 cells in plates, they were incubated at 37°C and 5% CO2 for 24 h to follow the cytotoxicity potentials of AgNPs, ranging from 0 µg/mL to 1000 µg/mL against the normal cells. After the above treatment, the MTT assay with the standard protocol of a 4 h incubation was performed. In the end, the cell viability average percentage was gained after following the absorbance at 490 nm and the below equation [18]:

% Cell viability = Absorbance of AgNps treated cells Absorbance of untreated cells × 100 .

2.5 In vivo design

In a recent study, a total of 80 rats, each weighing between 220 and 230 g, were utilized. Sepsis was induced in all subjects, with the control group exception, through the cecal ligation and puncture method. After the anesthesia, a midline laparotomy measuring 1 cm was conducted under sterile conditions. The cecum was secured firmly between the cecal floor and the ileocecal cap utilizing a 4/0 silk suture. A 16-gauge needle was employed to create four perforations from the mesentery’s opposite side to the cecum. Following this procedure, the cecum was realigned and secured with 4/0 silk sutures [19].

In vivo groups:

  1. AgNPs (20 µg/kg) group: administration of the AgNPs (20 µg/kg) after inducing the sepsis.

  2. AgNPs (100 µg/kg) group: administration of the AgNPs (100 µg/kg) after inducing the sepsis.

  3. Control group.

  4. Untreated group.

Upon completion of the study, the animals were humanely euthanized. Subsequently, the duodenum, stomach, liver, lungs, and kidneys were removed and rinsed with a saline solution [19].

The malondialdehyde (MDA) (µM/mg protein), glutathione (GSH) (mM/mg protein), and superoxide dismutases (SOD) (U/mg protein) concentrations in several tissues were measured by the techniques described by Sun et al. [20], Sedlak and Lindsay [21], and Ohkawa et al. [22], respectively.

The quantification of TNF-α and IL-1β mRNA expression levels in tissues was conducted utilizing the methodology established by Livak and Schmittgen [23].

2.6 Statistical analysis

Origin Pro version 9.1 software was used for the statistical analysis of the data. Each experiment was conducted in triplicate. ANOVA was utilized alongside the least significant difference test to determine notable changes (p < 0.01).

3 Results and discussion

3.1 Chemical characterization of AgNPs

Figure 1 showcases the silver nanoparticles FT-IR spectrum, illustrating the peaks related to the Ag–O presence at 519, 628, and 718 cm−1, which validate the Ag NPs formation. As it was reported in the previous studies, there are clear peaks with the minor deviations in the green-mediated Ag NPs [24,25]. The spectrum peaks reported are related to the C. intybus extract organic compounds. The previous reports about the plant extract indicated the presence of triterpenes, flavonoid, and phenolic compounds in the surface of Ag NPs [24,25,26,27,28,29,30]. In our study, the peaks related to the O–H, C–H, C═C, C═O, –C–O and C–O–C were reported in 3382, 2929, 1387, 1612, 1103 and 1037 cm−1, respectively.

Figure 1 FT-IR analysis of NPs@Cichorium intybus.
Figure 1

FT-IR analysis of NPs@Cichorium intybus.

Figure 2 illustrates a representative UV-vis spectrum of NPs produced using plant extract. It is attributed to the surface surface plasmon resonance phenomenon excitation. The spectra exhibit a characteristic absorbance peak at 452 nm, signifying the synthesis of AgNPs through the utilization of the C. intybus.

Figure 2 UV-vis analysis of NPs@Cichorium intybus.
Figure 2

UV-vis analysis of NPs@Cichorium intybus.

TEM and SEM are highly effective methods for analyzing surface characteristics, such as NP dimensions, structure, and form. The SEM and TEM pictures of the AgNPs reveal their consistent spherical shape. Based on the results, the mean size of AgNPs measures 35.29 nm (Figures 3 and 4). Our findings are further corroborated by earlier research [31].

Figure 3 SEM image of NPs@Cichorium intybus.
Figure 3

SEM image of NPs@Cichorium intybus.

Figure 4 TEM image of NPs@Cichorium intybus.
Figure 4

TEM image of NPs@Cichorium intybus.

The XRD is widely recognized as an effective technique for investigating various NPs. The XRD pattern presented in Figure 5 demonstrates the production of NPs@Cichorium intybus through an environmentally friendly approach. The findings confirm the presence of crystalline NPs@Cichorium intybus characterized by a small size. The 2θ value data was compared against the standard JCPD card 04-0783 database for verification. The identified peaks at 2θ values of 77.4, 65.1, and 37.8 corresponded to the crystal planes 311, 220, and 111, respectively. The NPs were determined to possess a crystal size of 41.52 nm, as calculated using Scherer’s equation.

Figure 5 XRD analysis of NPs@Cichorium intybus.
Figure 5

XRD analysis of NPs@Cichorium intybus.

3.2 Therapeutic efficacy of AgNPs on sepsis

The recent study examined the cytotoxic effects of AgNPs on the normal cell line known as HUVEC. Figure 6 illustrates that the IC50 value for the AgNPs exceeds 1,000 µg/mL. No significant toxicity was observed at concentrations below 1,000 µg/mL.

Figure 6 Activities of NPs@Cichorium intybus on the normal cell viability (%).
Figure 6

Activities of NPs@Cichorium intybus on the normal cell viability (%).

In the present study, the impact of AgNPs (20 and 100 µg/kg) on inflammatory mediators mRNA including IL-1 and TNF-α, oxidant–antioxidant balance, and their influence on gene expression levels were assessed in various organs. The TNF-α mRNA levels were lower in the CLP + 20 and 100 µg/kg group compared to the control group (Figures 7 and 8). AgNPs helped decrease oxidative stress by boosting endogenous antioxidants and improving the free radicals scavenging (Figures 9–13). AgNPs’ strong antioxidant ability may be linked to the sepsis cytokine cascade suppression.

Figure 7 Potential of NPs@Cichorium intybus on the TNF-α mRNA expression.
Figure 7

Potential of NPs@Cichorium intybus on the TNF-α mRNA expression.

Figure 8 Potential of NPs@Cichorium intybus on the IL-1β mRNA expression.
Figure 8

Potential of NPs@Cichorium intybus on the IL-1β mRNA expression.

Figure 9 Potential of NPs@Cichorium intybus on the MDA, GSH, and SOD in the duodenum.
Figure 9

Potential of NPs@Cichorium intybus on the MDA, GSH, and SOD in the duodenum.

Figure 10 Potential of NPs@Cichorium intybus on the MDA, GSH, and SOD in the stomach.
Figure 10

Potential of NPs@Cichorium intybus on the MDA, GSH, and SOD in the stomach.

Figure 11 Potential of NPs@Cichorium intybus on the MDA, GSH, and SOD in the lung.
Figure 11

Potential of NPs@Cichorium intybus on the MDA, GSH, and SOD in the lung.

Figure 12 Potential of NPs@Cichorium intybus on the MDA, GSH, and SOD in the kidney.
Figure 12

Potential of NPs@Cichorium intybus on the MDA, GSH, and SOD in the kidney.

Figure 13 Potential of NPs@Cichorium intybus on the MDA, GSH, and SOD in the liver.
Figure 13

Potential of NPs@Cichorium intybus on the MDA, GSH, and SOD in the liver.

In the comparison between the several organs of septic rats and the control group, it was seen that the AgNPs administration resulted in an increase in glutathione and superoxide dismutase levels. Additionally, there was a remarkable reduction in the levels of malondialdehyde (p < 0.01). The NPs@Cichorium intybus (100 µg/kg) demonstrated superior antioxidative properties compared to the dose of 20 µg/kg for all the evaluated parameters (Figures 9–13).

The advancement of novel sepsis therapy is heavily reliant on comprehending the physiological mechanisms associated with sepsis. The pathology of sepsis involves hemostatic systems, inflammatory agents, encompassing the various cell types’ activation and intricate and interconnected responses [32]. Within the context of sepsis, the TLR4 on the endothelium interacts with TNF-α, kinins, IL-6, IL-1, and C5a and bind to their specific receptors. Consequently, the endothelium was stimulated, possibly resulting in the onset of the sepsis cascade as a result of different surrounding factors like hyperglycemia, disrupted homeostasis, temperature changes, decreased blood flow, and lack of oxygen [5,6]. The extracellular mediator’s engagement with their respective receptors results in the subsequent signaling pathways activation, such as MAPK and PKC. The pathways can alter the gene expression patterns by various transcription factors [33]. The cell adhesion molecules increased expression on the endothelium surfaces, including E-selectin, ICAM-1, P-selectin, VCAM-1 and can enhance the circulating, rolling, and attachment leukocytes movement [5,6]. The phenotype of these cells is further modified by leukocyte–endothelial interactions. As the activation process takes place, the formation of ROS may be induced by NADPH oxidase, leading to the NO release and a rise in cell permeability [6]. According to this information, sepsis can be addressed by different approaches, including focusing on the inflammatory area with TNF-α and ICAM-1 or regulating the body’s ROS level with NPs production technology. Effective NPs for treating sepsis are categorized based on size and physicochemical characteristics [5,6].

The phytocomponent-conjugated AgNPs have been thoroughly investigated for a range of remedial uses, including anticancer, anti-inflammatory, antioxidant, antimicrobial, anticoagulant, and antidiabetic properties. The attachment of silver-based nanomaterial to plants decreases their harm to living organisms and boosts their ability to treat ailments [34,35,36]. The capping agents and phytochemicals variety found in plant extracts, combined with the diminutive large surface area and size of AgNPs, facilitates the effective capping agents adsorption onto the NPs [34,37]. The remedial efficacy of phytoconjugated AgNPs is improved across different biomedical applications. The antimicrobial and anti-inflammatory functions of AgNPs primarily rely on the mechanistic action of regulating the ROS, ICAM-1, TNF-α, IL-1β SOD, GSH, and MDA to eliminate inflammatory agents or diseases such as sepsis [34,35,36,37].

4 Conclusion

A sustainable and environmentally friendly method was employed in this research to efficiently synthesize spherical AgNPs (35.29 nm). The synthesis process utilized the C. intybus leaf extract. The 2,2-diphenyl-1-picrylhydrazyl radical scavenger exhibited impressive antioxidant properties. Various concentrations and consistent external conditions resulted in a significant enhancement of all morphological characteristics in wheat seedlings. Upon comparing the tissues of septic animals with those of the control group, it was discovered that the NPs@Cichorium intybus administration led to an increase in enzymes and a significant reduction in MDA levels. The TNF-α mRNA expression in the CLP + 20 and 100 µg/kg group exhibited a decrease. The high antioxidant potential of AgNPs could be linked to the cytokine cascade suppression during sepsis. These NPs decreased the oxidative stress by bolstering endogenous antioxidants and boosting the free radicals scavenging efficacies. The findings of the current investigation propose that AgNPs have the potential to serve as phytotoxic, antioxidants, and antibiotics agents in the forthcoming years due to their cost-effectiveness, non-toxic nature, anti-septic properties, and remarkable efficacy.

# Yang Liu is the first author and Zhiyun Liu is the co-first author.

  1. Funding information: This work was supported by the Shandong Provincial Natural Science Foundation (ZR2020QH308). Exploring the Mechanism of Banxia Xiexin Tang in Reducing Intestinal Mucosal Epithelial Cell Damage in Sepsis by Regulating Smad3 Expression and Inducing Increased Autophagy.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and consented to its submission to the journal, reviewed all the results, and approved the final version of the manuscript. Y.L.: conceptualization, data curation, formal analysis, investigation, methodology, project administration, resources, supervision, validation, visualization, writing –  original draft, and review & editing; Z.L.: conceptualization, data curation, formal analysis, investigation, methodology, project administration, supervision, validation, visualization, writing – original draft, and review & editing; T.B.: conceptualization, investigation, methodology, project administration, supervision, validation, visualization, writing – original draft, and review & editing; S.Z.: conceptualization, data curation, formal analysis, investigation, methodology, supervision, validation, visualization, writing – original draft, and review & editing; B.B.: conceptualization, data curation, formal analysis, investigation, methodology, project administration, validation, visualization, writing – original draft, and review & editing; H.M.: conceptualization, data curation, formal analysis, project administration, resources, supervision, validation, visualization, writing – original draft, and review & editing; L.K.: conceptualization, data curation, project administration, resources, supervision, validation, visualization, writing – original draft, and review & editing; F.Z.: conceptualization, data curation, formal analysis, investigation, methodology, project administration, resources, supervision, validation, visualization, writing – original draft, and review & editing.

  3. Conflict of interest: Authors state no conflict of interest.

  4. Ethical approval: The conducted research is not related to either human or animals use.

  5. Data availability statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

[1] Hunt A. Sepsis: an overview of the signs, symptoms, diagnosis, treatment and pathophysiology. Emerg Nurse. 2019;27:32–41.10.7748/en.2019.e1926Search in Google Scholar PubMed

[2] Pant A, Mackraj I, Govender T. Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology. J Biomed Sci. 2021;28(1):6.10.1186/s12929-020-00702-6Search in Google Scholar PubMed PubMed Central

[3] Schrag SJ, Farley MM, Petit S, Reingold A, Weston EJ, Pondo T, et al. Epidemiology of invasive early-onset neonatal sepsis, 2005 to 2014. Pediatrics. 2016;138(6):e20162013.10.1542/peds.2016-2013Search in Google Scholar PubMed

[4] Popescu CR, Cavanagh MMM, Tembo B, Chiume M, Lufesi N, Goldfarb DM, et al. Neonatal sepsis in low-income countries: epidemiology, diagnosis and prevention. Expert Rev Anti Infect Ther. 2020;18(5):443–52.10.1080/14787210.2020.1732818Search in Google Scholar PubMed

[5] Majeed S, Saravanan M, Danish M, Zakariya NA, Ibrahim MN, Rizvi EH, et al. Bioengineering of green-synthesized TAT peptide-functionalized silver nanoparticles for apoptotic cell-death mediated therapy of breast adenocarcinoma. Talanta. 2023 Feb;253:124026.10.1016/j.talanta.2022.124026Search in Google Scholar

[6] Barabadi H, Noqani H, Jounaki K, Nasiri A, Karami K, Jahani R. Functionalized bioengineered metal-based nanomaterials for cancer therapy. In Functionalized nanomaterials for cancer research. Elsevier, Netherland: Academic Press; 2024 Jan. p. 219–60.10.1016/B978-0-443-15518-5.00024-0Search in Google Scholar

[7] Rather GA, Nanda A, Pandit MA, Yahya S, Barabadi H, Saravanan M. Biosynthesis of zinc oxide nanoparticles using Bergenia ciliate aqueous extract and evaluation of their photocatalytic and antioxidant potential. Inorg Chem Commun. 2021 Dec;134:109020.10.1016/j.inoche.2021.109020Search in Google Scholar

[8] Barabadi H, Mobaraki K, Ashouri F, Noqani H, Jounaki K, Mostafavi E. Nanobiotechnological approaches in antinociceptive therapy: animal-based evidence for analgesic nanotherapeutics of bioengineered silver and gold nanomaterials. Adv Colloid Interface Sci. 2023 Jun;316:102917.10.1016/j.cis.2023.102917Search in Google Scholar PubMed

[9] Barabadi H, Jounaki K, Pishgahzadeh E, Morad H, Sadeghian-Abadi S, Vahidi H, et al. Antiviral potential of green-synthesized silver nanoparticles. In Handbook of microbial. nanotechnology. Elsevier, Netherland: Academic Press; 2022 Jan. p. 285–310.10.1016/B978-0-12-823426-6.00030-9Search in Google Scholar

[10] Barabadi H, Noqani H, Ashouri F, Prasad A, Jounaki K, Mobaraki K, et al. Nanobiotechnological approaches in anticoagulant therapy: the role of bioengineered silver and gold nanomaterials. Talanta. 2023 May;256:124279.10.1016/j.talanta.2023.124279Search in Google Scholar PubMed

[11] Mostafavi E, Zarepour A, Barabadi H, Zarrabi A, Truong LB, Medina-Cruz D. Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: beginning a new era in cancer theragnostic. Biotechnol Rep. 2022 Jun 1;34:e00714.10.1016/j.btre.2022.e00714Search in Google Scholar PubMed PubMed Central

[12] Nayak D, Chopra H, Chakrabartty I, Saravanan M, Barabadi H, Mohanta YK. Opportunities and challenges for bioengineered metallic nanoparticles as future nanomedicine. Bioeng nanomater wound healing infection control. 2023 Jan. p. 517–40.10.1016/B978-0-323-95376-4.00012-5Search in Google Scholar

[13] Lakkireddy HR, Bazile DV. Nano-carriers for drug routeing – towards a new era. J Drug Target. 2019;27(5–6):525–41.10.1080/1061186X.2018.1561891Search in Google Scholar PubMed

[14] Hou XC, Zhang XF, Zhao WY, Zeng CX, Deng BB, McComb DW, et al. Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis. Nat Nanotechnol. 2020;15:41.10.1038/s41565-019-0600-1Search in Google Scholar PubMed PubMed Central

[15] Yu H, Jin FY, Liu D, Shu GF, Wang XJ, Qi J, et al. ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury. Theranostics. 2020;10(5):2342–57.10.7150/thno.40395Search in Google Scholar PubMed PubMed Central

[16] Qie YQ, Yuan HF, von Roemeling CA, Chen YX, Liu XJ, Shih KD, et al. Surface modification of nanoparticles enables selective evasion of phagocytic clearance by distinct macrophage phenotypes. Sci Rep-Uk. 2016;6(1):1–11.10.1038/srep26269Search in Google Scholar PubMed PubMed Central

[17] Juibari MM, Abbasalizadeh S, Jouzani GS, Noruzi M. Intensified biosynthesis of silver nanoparticles using a native extremophilic Ureibacillus thermosphaericus strain. Mater Lett. 2011;65:1014–7.10.1016/j.matlet.2010.12.056Search in Google Scholar

[18] Pirabbasi E, Zangeneh MM, Zangeneh A, Moradi R, Kalantar M. Chemical characterization and effect of Ziziphora clinopodioides green-synthesized silver nanoparticles on cytotoxicity, antioxidant, and antidiabetic activities in streptozotocin-induced hepatotoxicity in Wistar diabetic male rats. Food Sci Nutr. 2024 Mar;12(5):3443–51.10.1002/fsn3.4008Search in Google Scholar PubMed PubMed Central

[19] Zhou L, Yao Y, Wang Q, Wang P, Hong S, Kong Li. Effects of green decorated AgNPs on lignin-modified magnetic nanoparticles mediated by Cydonia on cecal ligation and puncture-induced sepsis. Open Chem. 2023;21(1):20230142.10.1515/chem-2023-0142Search in Google Scholar

[20] Sun Y, Oberley LW, Li YA. Simple method for clinical assay of superoxide dismutase. Clin Chem. 1988;34:497–500.10.1093/clinchem/34.3.497Search in Google Scholar

[21] Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem. 1968;25:191–205.10.1016/0003-2697(68)90092-4Search in Google Scholar PubMed

[22] Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351–8.10.1016/0003-2697(79)90738-3Search in Google Scholar PubMed

[23] Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 2001;25:402–28.10.1006/meth.2001.1262Search in Google Scholar PubMed

[24] Elemike EE, Onwudiwe DC, Ekennia AC, Ehiri RC, Nnaji NJ. Phytosynthesis of silver nanoparticles using aqueous leaf extracts of Lippia citriodora: antimicrobial, larvicidal and photocatalytic evaluations. Mater Sci Eng C. 2017;75:980–9.10.1016/j.msec.2017.02.161Search in Google Scholar PubMed

[25] Loo YY, Rukayadi Y, Nor-Khaizura M-A-R, Kuan CH, Chieng BW, Nishibuchi M, et al. In vitro antimicrobial activity of green synthesized silver nanoparticles against selected gram-negative foodborne pathogens. Front Microbiol. 2018;9:1555.10.3389/fmicb.2018.01555Search in Google Scholar PubMed PubMed Central

[26] Vanaja M, Gnanajobitha G, Paulkumar K, Rajeshkumar S, Malarkodi C, Annadurai G. Phytosynthesis of silver nanoparticles by Cissus quadrangularis: influence of physicochemical factors. J Nanostruct Chem. 2013;3:17.10.1186/2193-8865-3-17Search in Google Scholar

[27] Salem SS, El-Belely EF, Niedbała G, Alnoman MM, Hassan SE-D, Eid AM, et al. Bactericidal and in-vitro cytotoxic efficacy of silver nanoparticles (Ag-NPs) fabricated by endophytic actinomycetes and their use as coating for the textile fabrics. Nanomaterials. 2020;10:2082.10.3390/nano10102082Search in Google Scholar PubMed PubMed Central

[28] Kang JH, Chae JB, Kim C. A multi-functional chemosensor for highly selective ratiometric fluorescent detection of silver (I) ion and dual turn-on fluorescent and colorimetric detection of sulfide. R Soc Open Sci. 2018;5:180293.10.1098/rsos.180293Search in Google Scholar PubMed PubMed Central

[29] Elumalai K, Velmurugan S. Green synthesis, characterization and antimicrobial activities of zinc oxide nanoparticles from the leaf extract of Azadirachta indica (L.). Appl Surf Sci. 2015;345:329–36.10.1016/j.apsusc.2015.03.176Search in Google Scholar

[30] Alqadi M, Abo Noqtah O, Alzoubi F, Alzouby J, Aljarrah K. PH effect on the aggregation of silver nanoparticles synthesized by chemical reduction. Mater Sci Pol. 2014;32:107–11.10.2478/s13536-013-0166-9Search in Google Scholar

[31] Khan FA, Zahoor M, Jalal A, Rahman AU. Green synthesis of silver nanoparticles by using Ziziphus nummularia leaves aqueous extract and their biological activities. J Nanomater. 2016;2016:8026843.10.1155/2016/8026843Search in Google Scholar

[32] Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood. 2003;101(10):3765–77.10.1182/blood-2002-06-1887Search in Google Scholar PubMed

[33] Huang M, Cai SL, Su JQ. The pathogenesis of sepsis and potential therapeutic targets. Int J Mol Sci. 2019;20(21):5376.10.3390/ijms20215376Search in Google Scholar PubMed PubMed Central

[34] Majeed M, Hakeem KR, Rehman RU. Synergistic effect of plant extract coupled silver nanoparticles in various therapeutic applications – present insights and bottlenecks. Chemosphere. 2022 Feb;288(Pt 2):132527.10.1016/j.chemosphere.2021.132527Search in Google Scholar PubMed

[35] Fahimirad S, Ajalloueian F, Ghorbanpour M. Synthesis and therapeutic potential of silver nanomaterials derived from plant extracts. Ecotoxicol Environ Saf. 2019 Jan;168:260–78.10.1016/j.ecoenv.2018.10.017Search in Google Scholar PubMed

[36] Singh H, Du J, Singh P, Yi TH. Ecofriendly synthesis of silver and gold nanoparticles by Euphrasia officinalis leaf extract and its biomedical applications. Artif Cell Nanomed Biotechnol. 2018 Sep;46(6):1163–70.10.1080/21691401.2017.1362417Search in Google Scholar PubMed

[37] Saratale RG, Benelli G, Kumar G, Kim DS, Saratale GD. Bio-fabrication of silver nanoparticles using the leaf extract of an ancient herbal medicine, dandelion (Taraxacum officinale), evaluation of their antioxidant, anticancer potential, and antimicrobial activity against phytopathogens. Environ Sci Pollut Res Int. 2018 Apr;25(11):10392–406.10.1007/s11356-017-9581-5Search in Google Scholar PubMed

Received: 2024-04-10
Revised: 2024-08-10
Accepted: 2024-09-06
Published Online: 2024-10-28

© 2024 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Articles in the same Issue

  1. Regular Articles
  2. Porous silicon nanostructures: Synthesis, characterization, and their antifungal activity
  3. Biochar from de-oiled Chlorella vulgaris and its adsorption on antibiotics
  4. Phytochemicals profiling, in vitro and in vivo antidiabetic activity, and in silico studies on Ajuga iva (L.) Schreb.: A comprehensive approach
  5. Synthesis, characterization, in silico and in vitro studies of novel glycoconjugates as potential antibacterial, antifungal, and antileishmanial agents
  6. Sonochemical synthesis of gold nanoparticles mediated by potato starch: Its performance in the treatment of esophageal cancer
  7. Computational study of ADME-Tox prediction of selected phytochemicals from Punica granatum peels
  8. Phytochemical analysis, in vitro antioxidant and antifungal activities of extracts and essential oil derived from Artemisia herba-alba Asso
  9. Two triazole-based coordination polymers: Synthesis and crystal structure characterization
  10. Phytochemical and physicochemical studies of different apple varieties grown in Morocco
  11. Synthesis of multi-template molecularly imprinted polymers (MT-MIPs) for isolating ethyl para-methoxycinnamate and ethyl cinnamate from Kaempferia galanga L., extract with methacrylic acid as functional monomer
  12. Nutraceutical potential of Mesembryanthemum forsskaolii Hochst. ex Bioss.: Insights into its nutritional composition, phytochemical contents, and antioxidant activity
  13. Evaluation of influence of Butea monosperma floral extract on inflammatory biomarkers
  14. Cannabis sativa L. essential oil: Chemical composition, anti-oxidant, anti-microbial properties, and acute toxicity: In vitro, in vivo, and in silico study
  15. The effect of gamma radiation on 5-hydroxymethylfurfural conversion in water and dimethyl sulfoxide
  16. Hollow mushroom nanomaterials for potentiometric sensing of Pb2+ ions in water via the intercalation of iodide ions into the polypyrrole matrix
  17. Determination of essential oil and chemical composition of St. John’s Wort
  18. Computational design and in vitro assay of lantadene-based novel inhibitors of NS3 protease of dengue virus
  19. Anti-parasitic activity and computational studies on a novel labdane diterpene from the roots of Vachellia nilotica
  20. Microbial dynamics and dehydrogenase activity in tomato (Lycopersicon esculentum Mill.) rhizospheres: Impacts on growth and soil health across different soil types
  21. Correlation between in vitro anti-urease activity and in silico molecular modeling approach of novel imidazopyridine–oxadiazole hybrids derivatives
  22. Spatial mapping of indoor air quality in a light metro system using the geographic information system method
  23. Iron indices and hemogram in renal anemia and the improvement with Tribulus terrestris green-formulated silver nanoparticles applied on rat model
  24. Integrated track of nano-informatics coupling with the enrichment concept in developing a novel nanoparticle targeting ERK protein in Naegleria fowleri
  25. Cytotoxic and phytochemical screening of Solanum lycopersicum–Daucus carota hydro-ethanolic extract and in silico evaluation of its lycopene content as anticancer agent
  26. Protective activities of silver nanoparticles containing Panax japonicus on apoptotic, inflammatory, and oxidative alterations in isoproterenol-induced cardiotoxicity
  27. pH-based colorimetric detection of monofunctional aldehydes in liquid and gas phases
  28. Investigating the effect of resveratrol on apoptosis and regulation of gene expression of Caco-2 cells: Unravelling potential implications for colorectal cancer treatment
  29. Metformin inhibits knee osteoarthritis induced by type 2 diabetes mellitus in rats: S100A8/9 and S100A12 as players and therapeutic targets
  30. Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized rats
  31. Synthesis of new analogs of N-substituted(benzoylamino)-1,2,3,6-tetrahydropyridines
  32. Response of yield and quality of Japonica rice to different gradients of moisture deficit at grain-filling stage in cold regions
  33. Preparation of an inclusion complex of nickel-based β-cyclodextrin: Characterization and accelerating the osteoarthritis articular cartilage repair
  34. Empagliflozin-loaded nanomicelles responsive to reactive oxygen species for renal ischemia/reperfusion injury protection
  35. Preparation and pharmacodynamic evaluation of sodium aescinate solid lipid nanoparticles
  36. Assessment of potentially toxic elements and health risks of agricultural soil in Southwest Riyadh, Saudi Arabia
  37. Theoretical investigation of hydrogen-rich fuel production through ammonia decomposition
  38. Biosynthesis and screening of cobalt nanoparticles using citrus species for antimicrobial activity
  39. Investigating the interplay of genetic variations, MCP-1 polymorphism, and docking with phytochemical inhibitors for combatting dengue virus pathogenicity through in silico analysis
  40. Ultrasound induced biosynthesis of silver nanoparticles embedded into chitosan polymers: Investigation of its anti-cutaneous squamous cell carcinoma effects
  41. Copper oxide nanoparticles-mediated Heliotropium bacciferum leaf extract: Antifungal activity and molecular docking assays against strawberry pathogens
  42. Sprouted wheat flour for improving physical, chemical, rheological, microbial load, and quality properties of fino bread
  43. Comparative toxicity assessment of fisetin-aided artificial intelligence-assisted drug design targeting epibulbar dermoid through phytochemicals
  44. Acute toxicity and anti-inflammatory activity of bis-thiourea derivatives
  45. Anti-diabetic activity-guided isolation of α-amylase and α-glucosidase inhibitory terpenes from Capsella bursa-pastoris Linn.
  46. GC–MS analysis of Lactobacillus plantarum YW11 metabolites and its computational analysis on familial pulmonary fibrosis hub genes
  47. Green formulation of copper nanoparticles by Pistacia khinjuk leaf aqueous extract: Introducing a novel chemotherapeutic drug for the treatment of prostate cancer
  48. Improved photocatalytic properties of WO3 nanoparticles for Malachite green dye degradation under visible light irradiation: An effect of La doping
  49. One-pot synthesis of a network of Mn2O3–MnO2–poly(m-methylaniline) composite nanorods on a polypyrrole film presents a promising and efficient optoelectronic and solar cell device
  50. Groundwater quality and health risk assessment of nitrate and fluoride in Al Qaseem area, Saudi Arabia
  51. A comparative study of the antifungal efficacy and phytochemical composition of date palm leaflet extracts
  52. Processing of alcohol pomelo beverage (Citrus grandis (L.) Osbeck) using saccharomyces yeast: Optimization, physicochemical quality, and sensory characteristics
  53. Specialized compounds of four Cameroonian spices: Isolation, characterization, and in silico evaluation as prospective SARS-CoV-2 inhibitors
  54. Identification of a novel drug target in Porphyromonas gingivalis by a computational genome analysis approach
  55. Physico-chemical properties and durability of a fly-ash-based geopolymer
  56. FMS-like tyrosine kinase 3 inhibitory potentials of some phytochemicals from anti-leukemic plants using computational chemical methodologies
  57. Wild Thymus zygis L. ssp. gracilis and Eucalyptus camaldulensis Dehnh.: Chemical composition, antioxidant and antibacterial activities of essential oils
  58. 3D-QSAR, molecular docking, ADMET, simulation dynamic, and retrosynthesis studies on new styrylquinolines derivatives against breast cancer
  59. Deciphering the influenza neuraminidase inhibitory potential of naturally occurring biflavonoids: An in silico approach
  60. Determination of heavy elements in agricultural regions, Saudi Arabia
  61. Synthesis and characterization of antioxidant-enriched Moringa oil-based edible oleogel
  62. Ameliorative effects of thistle and thyme honeys on cyclophosphamide-induced toxicity in mice
  63. Study of phytochemical compound and antipyretic activity of Chenopodium ambrosioides L. fractions
  64. Investigating the adsorption mechanism of zinc chloride-modified porous carbon for sulfadiazine removal from water
  65. Performance repair of building materials using alumina and silica composite nanomaterials with electrodynamic properties
  66. Effects of nanoparticles on the activity and resistance genes of anaerobic digestion enzymes in livestock and poultry manure containing the antibiotic tetracycline
  67. Effect of copper nanoparticles green-synthesized using Ocimum basilicum against Pseudomonas aeruginosa in mice lung infection model
  68. Cardioprotective effects of nanoparticles green formulated by Spinacia oleracea extract on isoproterenol-induced myocardial infarction in mice by the determination of PPAR-γ/NF-κB pathway
  69. Anti-OTC antibody-conjugated fluorescent magnetic/silica and fluorescent hybrid silica nanoparticles for oxytetracycline detection
  70. Curcumin conjugated zinc nanoparticles for the treatment of myocardial infarction
  71. Identification and in silico screening of natural phloroglucinols as potential PI3Kα inhibitors: A computational approach for drug discovery
  72. Exploring the phytochemical profile and antioxidant evaluation: Molecular docking and ADMET analysis of main compounds from three Solanum species in Saudi Arabia
  73. Unveiling the molecular composition and biological properties of essential oil derived from the leaves of wild Mentha aquatica L.: A comprehensive in vitro and in silico exploration
  74. Analysis of bioactive compounds present in Boerhavia elegans seeds by GC-MS
  75. Homology modeling and molecular docking study of corticotrophin-releasing hormone: An approach to treat stress-related diseases
  76. LncRNA MIR17HG alleviates heart failure via targeting MIR17HG/miR-153-3p/SIRT1 axis in in vitro model
  77. Development and validation of a stability indicating UPLC-DAD method coupled with MS-TQD for ramipril and thymoquinone in bioactive SNEDDS with in silico toxicity analysis of ramipril degradation products
  78. Biosynthesis of Ag/Cu nanocomposite mediated by Curcuma longa: Evaluation of its antibacterial properties against oral pathogens
  79. Development of AMBER-compliant transferable force field parameters for polytetrafluoroethylene
  80. Treatment of gestational diabetes by Acroptilon repens leaf aqueous extract green-formulated iron nanoparticles in rats
  81. Development and characterization of new ecological adsorbents based on cardoon wastes: Application to brilliant green adsorption
  82. A fast, sensitive, greener, and stability-indicating HPLC method for the standardization and quantitative determination of chlorhexidine acetate in commercial products
  83. Assessment of Se, As, Cd, Cr, Hg, and Pb content status in Ankang tea plantations of China
  84. Effect of transition metal chloride (ZnCl2) on low-temperature pyrolysis of high ash bituminous coal
  85. Evaluating polyphenol and ascorbic acid contents, tannin removal ability, and physical properties during hydrolysis and convective hot-air drying of cashew apple powder
  86. Development and characterization of functional low-fat frozen dairy dessert enhanced with dried lemongrass powder
  87. Scrutinizing the effect of additive and synergistic antibiotics against carbapenem-resistant Pseudomonas aeruginosa
  88. Preparation, characterization, and determination of the therapeutic effects of copper nanoparticles green-formulated by Pistacia atlantica in diabetes-induced cardiac dysfunction in rat
  89. Antioxidant and antidiabetic potentials of methoxy-substituted Schiff bases using in vitro, in vivo, and molecular simulation approaches
  90. Anti-melanoma cancer activity and chemical profile of the essential oil of Seseli yunnanense Franch
  91. Molecular docking analysis of subtilisin-like alkaline serine protease (SLASP) and laccase with natural biopolymers
  92. Overcoming methicillin resistance by methicillin-resistant Staphylococcus aureus: Computational evaluation of napthyridine and oxadiazoles compounds for potential dual inhibition of PBP-2a and FemA proteins
  93. Exploring novel antitubercular agents: Innovative design of 2,3-diaryl-quinoxalines targeting DprE1 for effective tuberculosis treatment
  94. Drimia maritima flowers as a source of biologically potent components: Optimization of bioactive compound extractions, isolation, UPLC–ESI–MS/MS, and pharmacological properties
  95. Estimating molecular properties, drug-likeness, cardiotoxic risk, liability profile, and molecular docking study to characterize binding process of key phyto-compounds against serotonin 5-HT2A receptor
  96. Fabrication of β-cyclodextrin-based microgels for enhancing solubility of Terbinafine: An in-vitro and in-vivo toxicological evaluation
  97. Phyto-mediated synthesis of ZnO nanoparticles and their sunlight-driven photocatalytic degradation of cationic and anionic dyes
  98. Monosodium glutamate induces hypothalamic–pituitary–adrenal axis hyperactivation, glucocorticoid receptors down-regulation, and systemic inflammatory response in young male rats: Impact on miR-155 and miR-218
  99. Quality control analyses of selected honey samples from Serbia based on their mineral and flavonoid profiles, and the invertase activity
  100. Eco-friendly synthesis of silver nanoparticles using Phyllanthus niruri leaf extract: Assessment of antimicrobial activity, effectiveness on tropical neglected mosquito vector control, and biocompatibility using a fibroblast cell line model
  101. Green synthesis of silver nanoparticles containing Cichorium intybus to treat the sepsis-induced DNA damage in the liver of Wistar albino rats
  102. Quality changes of durian pulp (Durio ziberhinus Murr.) in cold storage
  103. Study on recrystallization process of nitroguanidine by directly adding cold water to control temperature
  104. Determination of heavy metals and health risk assessment in drinking water in Bukayriyah City, Saudi Arabia
  105. Larvicidal properties of essential oils of three Artemisia species against the chemically insecticide-resistant Nile fever vector Culex pipiens (L.) (Diptera: Culicidae): In vitro and in silico studies
  106. Design, synthesis, characterization, and theoretical calculations, along with in silico and in vitro antimicrobial proprieties of new isoxazole-amide conjugates
  107. The impact of drying and extraction methods on total lipid, fatty acid profile, and cytotoxicity of Tenebrio molitor larvae
  108. A zinc oxide–tin oxide–nerolidol hybrid nanomaterial: Efficacy against esophageal squamous cell carcinoma
  109. Research on technological process for production of muskmelon juice (Cucumis melo L.)
  110. Physicochemical components, antioxidant activity, and predictive models for quality of soursop tea (Annona muricata L.) during heat pump drying
  111. Characterization and application of Fe1−xCoxFe2O4 nanoparticles in Direct Red 79 adsorption
  112. Torilis arvensis ethanolic extract: Phytochemical analysis, antifungal efficacy, and cytotoxicity properties
  113. Magnetite–poly-1H pyrrole dendritic nanocomposite seeded on poly-1H pyrrole: A promising photocathode for green hydrogen generation from sanitation water without using external sacrificing agent
  114. HPLC and GC–MS analyses of phytochemical compounds in Haloxylon salicornicum extract: Antibacterial and antifungal activity assessment of phytopathogens
  115. Efficient and stable to coking catalysts of ethanol steam reforming comprised of Ni + Ru loaded on MgAl2O4 + LnFe0.7Ni0.3O3 (Ln = La, Pr) nanocomposites prepared via cost-effective procedure with Pluronic P123 copolymer
  116. Nitrogen and boron co-doped carbon dots probe for selectively detecting Hg2+ in water samples and the detection mechanism
  117. Heavy metals in road dust from typical old industrial areas of Wuhan: Seasonal distribution and bioaccessibility-based health risk assessment
  118. Phytochemical profiling and bioactivity evaluation of CBD- and THC-enriched Cannabis sativa extracts: In vitro and in silico investigation of antioxidant and anti-inflammatory effects
  119. Investigating dye adsorption: The role of surface-modified montmorillonite nanoclay in kinetics, isotherms, and thermodynamics
  120. Antimicrobial activity, induction of ROS generation in HepG2 liver cancer cells, and chemical composition of Pterospermum heterophyllum
  121. Study on the performance of nanoparticle-modified PVDF membrane in delaying membrane aging
  122. Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes
  123. Review Articles
  124. Structural aspects of Pt(η3-X1N1X2)(PL) (X1,2 = O, C, or Se) and Pt(η3-N1N2X1)(PL) (X1 = C, S, or Se) derivatives
  125. Biosurfactants in biocorrosion and corrosion mitigation of metals: An overview
  126. Stimulus-responsive MOF–hydrogel composites: Classification, preparation, characterization, and their advancement in medical treatments
  127. Electrochemical dissolution of titanium under alternating current polarization to obtain its dioxide
  128. Special Issue on Recent Trends in Green Chemistry
  129. Phytochemical screening and antioxidant activity of Vitex agnus-castus L.
  130. Phytochemical study, antioxidant activity, and dermoprotective activity of Chenopodium ambrosioides (L.)
  131. Exploitation of mangliculous marine fungi, Amarenographium solium, for the green synthesis of silver nanoparticles and their activity against multiple drug-resistant bacteria
  132. Study of the phytotoxicity of margines on Pistia stratiotes L.
  133. Special Issue on Advanced Nanomaterials for Energy, Environmental and Biological Applications - Part III
  134. Impact of biogenic zinc oxide nanoparticles on growth, development, and antioxidant system of high protein content crop (Lablab purpureus L.) sweet
  135. Green synthesis, characterization, and application of iron and molybdenum nanoparticles and their composites for enhancing the growth of Solanum lycopersicum
  136. Green synthesis of silver nanoparticles from Olea europaea L. extracted polysaccharides, characterization, and its assessment as an antimicrobial agent against multiple pathogenic microbes
  137. Photocatalytic treatment of organic dyes using metal oxides and nanocomposites: A quantitative study
  138. Antifungal, antioxidant, and photocatalytic activities of greenly synthesized iron oxide nanoparticles
  139. Special Issue on Phytochemical and Pharmacological Scrutinization of Medicinal Plants
  140. Hepatoprotective effects of safranal on acetaminophen-induced hepatotoxicity in rats
  141. Chemical composition and biological properties of Thymus capitatus plants from Algerian high plains: A comparative and analytical study
  142. Chemical composition and bioactivities of the methanol root extracts of Saussurea costus
  143. In vivo protective effects of vitamin C against cyto-genotoxicity induced by Dysphania ambrosioides aqueous extract
  144. Insights about the deleterious impact of a carbamate pesticide on some metabolic immune and antioxidant functions and a focus on the protective ability of a Saharan shrub and its anti-edematous property
  145. A comprehensive review uncovering the anticancerous potential of genkwanin (plant-derived compound) in several human carcinomas
  146. A study to investigate the anticancer potential of carvacrol via targeting Notch signaling in breast cancer
  147. Assessment of anti-diabetic properties of Ziziphus oenopolia (L.) wild edible fruit extract: In vitro and in silico investigations through molecular docking analysis
  148. Optimization of polyphenol extraction, phenolic profile by LC-ESI-MS/MS, antioxidant, anti-enzymatic, and cytotoxic activities of Physalis acutifolia
  149. Phytochemical screening, antioxidant properties, and photo-protective activities of Salvia balansae de Noé ex Coss
  150. Antihyperglycemic, antiglycation, anti-hypercholesteremic, and toxicity evaluation with gas chromatography mass spectrometry profiling for Aloe armatissima leaves
  151. Phyto-fabrication and characterization of gold nanoparticles by using Timur (Zanthoxylum armatum DC) and their effect on wound healing
  152. Does Erodium trifolium (Cav.) Guitt exhibit medicinal properties? Response elements from phytochemical profiling, enzyme-inhibiting, and antioxidant and antimicrobial activities
  153. Integrative in silico evaluation of the antiviral potential of terpenoids and its metal complexes derived from Homalomena aromatica based on main protease of SARS-CoV-2
  154. 6-Methoxyflavone improves anxiety, depression, and memory by increasing monoamines in mice brain: HPLC analysis and in silico studies
  155. Simultaneous extraction and quantification of hydrophilic and lipophilic antioxidants in Solanum lycopersicum L. varieties marketed in Saudi Arabia
  156. Biological evaluation of CH3OH and C2H5OH of Berberis vulgaris for in vivo antileishmanial potential against Leishmania tropica in murine models
https://doi.org/10.1515/chem-2024-0097
Keywords for this article
Cichorium intybus; cytotoxicity; sepsis-induced DNA damage; silver ‎ nanoparticles
Creative Commons
BY 4.0

Articles in the same Issue

  1. Regular Articles
  2. Porous silicon nanostructures: Synthesis, characterization, and their antifungal activity
  3. Biochar from de-oiled Chlorella vulgaris and its adsorption on antibiotics
  4. Phytochemicals profiling, in vitro and in vivo antidiabetic activity, and in silico studies on Ajuga iva (L.) Schreb.: A comprehensive approach
  5. Synthesis, characterization, in silico and in vitro studies of novel glycoconjugates as potential antibacterial, antifungal, and antileishmanial agents
  6. Sonochemical synthesis of gold nanoparticles mediated by potato starch: Its performance in the treatment of esophageal cancer
  7. Computational study of ADME-Tox prediction of selected phytochemicals from Punica granatum peels
  8. Phytochemical analysis, in vitro antioxidant and antifungal activities of extracts and essential oil derived from Artemisia herba-alba Asso
  9. Two triazole-based coordination polymers: Synthesis and crystal structure characterization
  10. Phytochemical and physicochemical studies of different apple varieties grown in Morocco
  11. Synthesis of multi-template molecularly imprinted polymers (MT-MIPs) for isolating ethyl para-methoxycinnamate and ethyl cinnamate from Kaempferia galanga L., extract with methacrylic acid as functional monomer
  12. Nutraceutical potential of Mesembryanthemum forsskaolii Hochst. ex Bioss.: Insights into its nutritional composition, phytochemical contents, and antioxidant activity
  13. Evaluation of influence of Butea monosperma floral extract on inflammatory biomarkers
  14. Cannabis sativa L. essential oil: Chemical composition, anti-oxidant, anti-microbial properties, and acute toxicity: In vitro, in vivo, and in silico study
  15. The effect of gamma radiation on 5-hydroxymethylfurfural conversion in water and dimethyl sulfoxide
  16. Hollow mushroom nanomaterials for potentiometric sensing of Pb2+ ions in water via the intercalation of iodide ions into the polypyrrole matrix
  17. Determination of essential oil and chemical composition of St. John’s Wort
  18. Computational design and in vitro assay of lantadene-based novel inhibitors of NS3 protease of dengue virus
  19. Anti-parasitic activity and computational studies on a novel labdane diterpene from the roots of Vachellia nilotica
  20. Microbial dynamics and dehydrogenase activity in tomato (Lycopersicon esculentum Mill.) rhizospheres: Impacts on growth and soil health across different soil types
  21. Correlation between in vitro anti-urease activity and in silico molecular modeling approach of novel imidazopyridine–oxadiazole hybrids derivatives
  22. Spatial mapping of indoor air quality in a light metro system using the geographic information system method
  23. Iron indices and hemogram in renal anemia and the improvement with Tribulus terrestris green-formulated silver nanoparticles applied on rat model
  24. Integrated track of nano-informatics coupling with the enrichment concept in developing a novel nanoparticle targeting ERK protein in Naegleria fowleri
  25. Cytotoxic and phytochemical screening of Solanum lycopersicum–Daucus carota hydro-ethanolic extract and in silico evaluation of its lycopene content as anticancer agent
  26. Protective activities of silver nanoparticles containing Panax japonicus on apoptotic, inflammatory, and oxidative alterations in isoproterenol-induced cardiotoxicity
  27. pH-based colorimetric detection of monofunctional aldehydes in liquid and gas phases
  28. Investigating the effect of resveratrol on apoptosis and regulation of gene expression of Caco-2 cells: Unravelling potential implications for colorectal cancer treatment
  29. Metformin inhibits knee osteoarthritis induced by type 2 diabetes mellitus in rats: S100A8/9 and S100A12 as players and therapeutic targets
  30. Effect of silver nanoparticles formulated by Silybum marianum on menopausal urinary incontinence in ovariectomized rats
  31. Synthesis of new analogs of N-substituted(benzoylamino)-1,2,3,6-tetrahydropyridines
  32. Response of yield and quality of Japonica rice to different gradients of moisture deficit at grain-filling stage in cold regions
  33. Preparation of an inclusion complex of nickel-based β-cyclodextrin: Characterization and accelerating the osteoarthritis articular cartilage repair
  34. Empagliflozin-loaded nanomicelles responsive to reactive oxygen species for renal ischemia/reperfusion injury protection
  35. Preparation and pharmacodynamic evaluation of sodium aescinate solid lipid nanoparticles
  36. Assessment of potentially toxic elements and health risks of agricultural soil in Southwest Riyadh, Saudi Arabia
  37. Theoretical investigation of hydrogen-rich fuel production through ammonia decomposition
  38. Biosynthesis and screening of cobalt nanoparticles using citrus species for antimicrobial activity
  39. Investigating the interplay of genetic variations, MCP-1 polymorphism, and docking with phytochemical inhibitors for combatting dengue virus pathogenicity through in silico analysis
  40. Ultrasound induced biosynthesis of silver nanoparticles embedded into chitosan polymers: Investigation of its anti-cutaneous squamous cell carcinoma effects
  41. Copper oxide nanoparticles-mediated Heliotropium bacciferum leaf extract: Antifungal activity and molecular docking assays against strawberry pathogens
  42. Sprouted wheat flour for improving physical, chemical, rheological, microbial load, and quality properties of fino bread
  43. Comparative toxicity assessment of fisetin-aided artificial intelligence-assisted drug design targeting epibulbar dermoid through phytochemicals
  44. Acute toxicity and anti-inflammatory activity of bis-thiourea derivatives
  45. Anti-diabetic activity-guided isolation of α-amylase and α-glucosidase inhibitory terpenes from Capsella bursa-pastoris Linn.
  46. GC–MS analysis of Lactobacillus plantarum YW11 metabolites and its computational analysis on familial pulmonary fibrosis hub genes
  47. Green formulation of copper nanoparticles by Pistacia khinjuk leaf aqueous extract: Introducing a novel chemotherapeutic drug for the treatment of prostate cancer
  48. Improved photocatalytic properties of WO3 nanoparticles for Malachite green dye degradation under visible light irradiation: An effect of La doping
  49. One-pot synthesis of a network of Mn2O3–MnO2–poly(m-methylaniline) composite nanorods on a polypyrrole film presents a promising and efficient optoelectronic and solar cell device
  50. Groundwater quality and health risk assessment of nitrate and fluoride in Al Qaseem area, Saudi Arabia
  51. A comparative study of the antifungal efficacy and phytochemical composition of date palm leaflet extracts
  52. Processing of alcohol pomelo beverage (Citrus grandis (L.) Osbeck) using saccharomyces yeast: Optimization, physicochemical quality, and sensory characteristics
  53. Specialized compounds of four Cameroonian spices: Isolation, characterization, and in silico evaluation as prospective SARS-CoV-2 inhibitors
  54. Identification of a novel drug target in Porphyromonas gingivalis by a computational genome analysis approach
  55. Physico-chemical properties and durability of a fly-ash-based geopolymer
  56. FMS-like tyrosine kinase 3 inhibitory potentials of some phytochemicals from anti-leukemic plants using computational chemical methodologies
  57. Wild Thymus zygis L. ssp. gracilis and Eucalyptus camaldulensis Dehnh.: Chemical composition, antioxidant and antibacterial activities of essential oils
  58. 3D-QSAR, molecular docking, ADMET, simulation dynamic, and retrosynthesis studies on new styrylquinolines derivatives against breast cancer
  59. Deciphering the influenza neuraminidase inhibitory potential of naturally occurring biflavonoids: An in silico approach
  60. Determination of heavy elements in agricultural regions, Saudi Arabia
  61. Synthesis and characterization of antioxidant-enriched Moringa oil-based edible oleogel
  62. Ameliorative effects of thistle and thyme honeys on cyclophosphamide-induced toxicity in mice
  63. Study of phytochemical compound and antipyretic activity of Chenopodium ambrosioides L. fractions
  64. Investigating the adsorption mechanism of zinc chloride-modified porous carbon for sulfadiazine removal from water
  65. Performance repair of building materials using alumina and silica composite nanomaterials with electrodynamic properties
  66. Effects of nanoparticles on the activity and resistance genes of anaerobic digestion enzymes in livestock and poultry manure containing the antibiotic tetracycline
  67. Effect of copper nanoparticles green-synthesized using Ocimum basilicum against Pseudomonas aeruginosa in mice lung infection model
  68. Cardioprotective effects of nanoparticles green formulated by Spinacia oleracea extract on isoproterenol-induced myocardial infarction in mice by the determination of PPAR-γ/NF-κB pathway
  69. Anti-OTC antibody-conjugated fluorescent magnetic/silica and fluorescent hybrid silica nanoparticles for oxytetracycline detection
  70. Curcumin conjugated zinc nanoparticles for the treatment of myocardial infarction
  71. Identification and in silico screening of natural phloroglucinols as potential PI3Kα inhibitors: A computational approach for drug discovery
  72. Exploring the phytochemical profile and antioxidant evaluation: Molecular docking and ADMET analysis of main compounds from three Solanum species in Saudi Arabia
  73. Unveiling the molecular composition and biological properties of essential oil derived from the leaves of wild Mentha aquatica L.: A comprehensive in vitro and in silico exploration
  74. Analysis of bioactive compounds present in Boerhavia elegans seeds by GC-MS
  75. Homology modeling and molecular docking study of corticotrophin-releasing hormone: An approach to treat stress-related diseases
  76. LncRNA MIR17HG alleviates heart failure via targeting MIR17HG/miR-153-3p/SIRT1 axis in in vitro model
  77. Development and validation of a stability indicating UPLC-DAD method coupled with MS-TQD for ramipril and thymoquinone in bioactive SNEDDS with in silico toxicity analysis of ramipril degradation products
  78. Biosynthesis of Ag/Cu nanocomposite mediated by Curcuma longa: Evaluation of its antibacterial properties against oral pathogens
  79. Development of AMBER-compliant transferable force field parameters for polytetrafluoroethylene
  80. Treatment of gestational diabetes by Acroptilon repens leaf aqueous extract green-formulated iron nanoparticles in rats
  81. Development and characterization of new ecological adsorbents based on cardoon wastes: Application to brilliant green adsorption
  82. A fast, sensitive, greener, and stability-indicating HPLC method for the standardization and quantitative determination of chlorhexidine acetate in commercial products
  83. Assessment of Se, As, Cd, Cr, Hg, and Pb content status in Ankang tea plantations of China
  84. Effect of transition metal chloride (ZnCl2) on low-temperature pyrolysis of high ash bituminous coal
  85. Evaluating polyphenol and ascorbic acid contents, tannin removal ability, and physical properties during hydrolysis and convective hot-air drying of cashew apple powder
  86. Development and characterization of functional low-fat frozen dairy dessert enhanced with dried lemongrass powder
  87. Scrutinizing the effect of additive and synergistic antibiotics against carbapenem-resistant Pseudomonas aeruginosa
  88. Preparation, characterization, and determination of the therapeutic effects of copper nanoparticles green-formulated by Pistacia atlantica in diabetes-induced cardiac dysfunction in rat
  89. Antioxidant and antidiabetic potentials of methoxy-substituted Schiff bases using in vitro, in vivo, and molecular simulation approaches
  90. Anti-melanoma cancer activity and chemical profile of the essential oil of Seseli yunnanense Franch
  91. Molecular docking analysis of subtilisin-like alkaline serine protease (SLASP) and laccase with natural biopolymers
  92. Overcoming methicillin resistance by methicillin-resistant Staphylococcus aureus: Computational evaluation of napthyridine and oxadiazoles compounds for potential dual inhibition of PBP-2a and FemA proteins
  93. Exploring novel antitubercular agents: Innovative design of 2,3-diaryl-quinoxalines targeting DprE1 for effective tuberculosis treatment
  94. Drimia maritima flowers as a source of biologically potent components: Optimization of bioactive compound extractions, isolation, UPLC–ESI–MS/MS, and pharmacological properties
  95. Estimating molecular properties, drug-likeness, cardiotoxic risk, liability profile, and molecular docking study to characterize binding process of key phyto-compounds against serotonin 5-HT2A receptor
  96. Fabrication of β-cyclodextrin-based microgels for enhancing solubility of Terbinafine: An in-vitro and in-vivo toxicological evaluation
  97. Phyto-mediated synthesis of ZnO nanoparticles and their sunlight-driven photocatalytic degradation of cationic and anionic dyes
  98. Monosodium glutamate induces hypothalamic–pituitary–adrenal axis hyperactivation, glucocorticoid receptors down-regulation, and systemic inflammatory response in young male rats: Impact on miR-155 and miR-218
  99. Quality control analyses of selected honey samples from Serbia based on their mineral and flavonoid profiles, and the invertase activity
  100. Eco-friendly synthesis of silver nanoparticles using Phyllanthus niruri leaf extract: Assessment of antimicrobial activity, effectiveness on tropical neglected mosquito vector control, and biocompatibility using a fibroblast cell line model
  101. Green synthesis of silver nanoparticles containing Cichorium intybus to treat the sepsis-induced DNA damage in the liver of Wistar albino rats
  102. Quality changes of durian pulp (Durio ziberhinus Murr.) in cold storage
  103. Study on recrystallization process of nitroguanidine by directly adding cold water to control temperature
  104. Determination of heavy metals and health risk assessment in drinking water in Bukayriyah City, Saudi Arabia
  105. Larvicidal properties of essential oils of three Artemisia species against the chemically insecticide-resistant Nile fever vector Culex pipiens (L.) (Diptera: Culicidae): In vitro and in silico studies
  106. Design, synthesis, characterization, and theoretical calculations, along with in silico and in vitro antimicrobial proprieties of new isoxazole-amide conjugates
  107. The impact of drying and extraction methods on total lipid, fatty acid profile, and cytotoxicity of Tenebrio molitor larvae
  108. A zinc oxide–tin oxide–nerolidol hybrid nanomaterial: Efficacy against esophageal squamous cell carcinoma
  109. Research on technological process for production of muskmelon juice (Cucumis melo L.)
  110. Physicochemical components, antioxidant activity, and predictive models for quality of soursop tea (Annona muricata L.) during heat pump drying
  111. Characterization and application of Fe1−xCoxFe2O4 nanoparticles in Direct Red 79 adsorption
  112. Torilis arvensis ethanolic extract: Phytochemical analysis, antifungal efficacy, and cytotoxicity properties
  113. Magnetite–poly-1H pyrrole dendritic nanocomposite seeded on poly-1H pyrrole: A promising photocathode for green hydrogen generation from sanitation water without using external sacrificing agent
  114. HPLC and GC–MS analyses of phytochemical compounds in Haloxylon salicornicum extract: Antibacterial and antifungal activity assessment of phytopathogens
  115. Efficient and stable to coking catalysts of ethanol steam reforming comprised of Ni + Ru loaded on MgAl2O4 + LnFe0.7Ni0.3O3 (Ln = La, Pr) nanocomposites prepared via cost-effective procedure with Pluronic P123 copolymer
  116. Nitrogen and boron co-doped carbon dots probe for selectively detecting Hg2+ in water samples and the detection mechanism
  117. Heavy metals in road dust from typical old industrial areas of Wuhan: Seasonal distribution and bioaccessibility-based health risk assessment
  118. Phytochemical profiling and bioactivity evaluation of CBD- and THC-enriched Cannabis sativa extracts: In vitro and in silico investigation of antioxidant and anti-inflammatory effects
  119. Investigating dye adsorption: The role of surface-modified montmorillonite nanoclay in kinetics, isotherms, and thermodynamics
  120. Antimicrobial activity, induction of ROS generation in HepG2 liver cancer cells, and chemical composition of Pterospermum heterophyllum
  121. Study on the performance of nanoparticle-modified PVDF membrane in delaying membrane aging
  122. Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes
  123. Review Articles
  124. Structural aspects of Pt(η3-X1N1X2)(PL) (X1,2 = O, C, or Se) and Pt(η3-N1N2X1)(PL) (X1 = C, S, or Se) derivatives
  125. Biosurfactants in biocorrosion and corrosion mitigation of metals: An overview
  126. Stimulus-responsive MOF–hydrogel composites: Classification, preparation, characterization, and their advancement in medical treatments
  127. Electrochemical dissolution of titanium under alternating current polarization to obtain its dioxide
  128. Special Issue on Recent Trends in Green Chemistry
  129. Phytochemical screening and antioxidant activity of Vitex agnus-castus L.
  130. Phytochemical study, antioxidant activity, and dermoprotective activity of Chenopodium ambrosioides (L.)
  131. Exploitation of mangliculous marine fungi, Amarenographium solium, for the green synthesis of silver nanoparticles and their activity against multiple drug-resistant bacteria
  132. Study of the phytotoxicity of margines on Pistia stratiotes L.
  133. Special Issue on Advanced Nanomaterials for Energy, Environmental and Biological Applications - Part III
  134. Impact of biogenic zinc oxide nanoparticles on growth, development, and antioxidant system of high protein content crop (Lablab purpureus L.) sweet
  135. Green synthesis, characterization, and application of iron and molybdenum nanoparticles and their composites for enhancing the growth of Solanum lycopersicum
  136. Green synthesis of silver nanoparticles from Olea europaea L. extracted polysaccharides, characterization, and its assessment as an antimicrobial agent against multiple pathogenic microbes
  137. Photocatalytic treatment of organic dyes using metal oxides and nanocomposites: A quantitative study
  138. Antifungal, antioxidant, and photocatalytic activities of greenly synthesized iron oxide nanoparticles
  139. Special Issue on Phytochemical and Pharmacological Scrutinization of Medicinal Plants
  140. Hepatoprotective effects of safranal on acetaminophen-induced hepatotoxicity in rats
  141. Chemical composition and biological properties of Thymus capitatus plants from Algerian high plains: A comparative and analytical study
  142. Chemical composition and bioactivities of the methanol root extracts of Saussurea costus
  143. In vivo protective effects of vitamin C against cyto-genotoxicity induced by Dysphania ambrosioides aqueous extract
  144. Insights about the deleterious impact of a carbamate pesticide on some metabolic immune and antioxidant functions and a focus on the protective ability of a Saharan shrub and its anti-edematous property
  145. A comprehensive review uncovering the anticancerous potential of genkwanin (plant-derived compound) in several human carcinomas
  146. A study to investigate the anticancer potential of carvacrol via targeting Notch signaling in breast cancer
  147. Assessment of anti-diabetic properties of Ziziphus oenopolia (L.) wild edible fruit extract: In vitro and in silico investigations through molecular docking analysis
  148. Optimization of polyphenol extraction, phenolic profile by LC-ESI-MS/MS, antioxidant, anti-enzymatic, and cytotoxic activities of Physalis acutifolia
  149. Phytochemical screening, antioxidant properties, and photo-protective activities of Salvia balansae de Noé ex Coss
  150. Antihyperglycemic, antiglycation, anti-hypercholesteremic, and toxicity evaluation with gas chromatography mass spectrometry profiling for Aloe armatissima leaves
  151. Phyto-fabrication and characterization of gold nanoparticles by using Timur (Zanthoxylum armatum DC) and their effect on wound healing
  152. Does Erodium trifolium (Cav.) Guitt exhibit medicinal properties? Response elements from phytochemical profiling, enzyme-inhibiting, and antioxidant and antimicrobial activities
  153. Integrative in silico evaluation of the antiviral potential of terpenoids and its metal complexes derived from Homalomena aromatica based on main protease of SARS-CoV-2
  154. 6-Methoxyflavone improves anxiety, depression, and memory by increasing monoamines in mice brain: HPLC analysis and in silico studies
  155. Simultaneous extraction and quantification of hydrophilic and lipophilic antioxidants in Solanum lycopersicum L. varieties marketed in Saudi Arabia
  156. Biological evaluation of CH3OH and C2H5OH of Berberis vulgaris for in vivo antileishmanial potential against Leishmania tropica in murine models
Sign up now to receive a 20% welcome discount
Institutional Access
How does access work?
Have an idea on how to improve our website?
Please write us.
© 2025 De Gruyter Brill
Downloaded on 6.12.2025 from https://www.degruyterbrill.com/document/doi/10.1515/chem-2024-0097/html
Scroll to top button