Successful extracorporeal membrane oxygenation resuscitation of patient with cardiogenic shock induced by phaeochromocytoma crisis mimicking hyperthyroidism: A case report
-
,
and
Abstract
A 29-year-old woman presented to the emergency department with the acute onset of palpitations, shortness of breath, and haemoptysis. She reported having an abortion (56 days of pregnancy) 1 week before admission because of hyperthyroidism diagnosis during pregnancy. The first diagnoses considered were cardiomyopathy associated with hyperthyroidism, acute left ventricular failure, and hyperthyroidism crisis. The young woman’s cardiocirculatory system collapsed within several hours. Hence, venoarterial extracorporeal membrane oxygenation (VA ECMO) was performed for this patient. Over the next 3 days after ECMO was established, repeat transthoracic echocardiography showed gradual improvements in biventricular function, and later the patient recovered almost completely. The patient’s blood pressure increased to 230/130 mm Hg when the ECMO catheter was removed, and then the diagnosis of phaeochromocytoma was suspected. Computed tomography showed a left suprarenal tumour. The tumour size was 5.8 cm × 5.7 cm with central necrosis. The vanillylmandelic acid concentration was 63.15 mg/24 h. Post-operation, pathology confirmed phaeochromocytoma. To our knowledge, this is the first case report of a patient with cardiogenic shock induced by phaeochromocytoma crisis mimicking hyperthyroidism which was successfully resuscitated by VA ECMO.
1 Introduction
Phaeochromocytoma arises from neuroectodermal tissue that secretes catecholamines and often presents various benign symptoms, such as headache, palpitations, and sweating, but can also present multiple organ failure. All kinds of acute diseases, such as acute coronary syndrome, cardiogenic shock, septic shock [1], preeclampsia, and amniotic fluid embolism [2], have been reported to be mimicked by phaeochromocytoma crisis (PCC). We are the first to report a patient with cardiogenic shock induced by PCC mimicking hyperthyroidism which was successfully resuscitated by venoarterial extracorporeal membrane oxygenation (VA ECMO).
2 Case report
A 29-year-old woman presented to the emergency department with the acute onset of palpitations, shortness of breath, and haemoptysis. She reported having an abortion (56 days of pregnancy) 1 week prior to admission because of a hyperthyroidism diagnosis during pregnancy; the thyroid function increased significantly (FT3: 7.03 pmol/L, FT4: 26.31 pmol/L, and TSH: 0.008 mIU/L). The patient denied using any drugs or tobacco, and there was no history of allergies. Her family history was normal. She was admitted to the endocrinology department under the consideration of cardiomyopathy associated with hyperthyroidism, acute left ventricular failure, and hyperthyroidism crisis as potential diagnoses.
On admission, she was conscious but displayed acrocyanosis, orthopnoea, excessive perspiration, moist cold skin, cough with pink bubbly expectorate, and respiratory distress. Her respiratory rate was 40 breaths/min, her oxygen saturation (SPO2) by pulse oximetry was 93% with an oxygen delivery rate of 15 L/min by hydrogen mass, and her heart rate was 156 beats/min with hypotension of 85/43 mm Hg with a dopamine dose of 8 µg/kg min. This dose was increased slowly. Her shell temperature was 36.3°C. Abdominal examination revealed a soft abdomen with no organ enlargement or mass. She had auscultation of the lungs with wheezes or crackles. Laboratory studies showed hyperglycaemia (glucose: 9.43 mmol/L), myocardial damage (troponin I: 29.02 ng/mL and creatine kinase-MB: 64 U/mL), and mild renal insufficiency (creatinine: 146.4 mmol/L and anuria lasting for 3 h); her PCT level was 24 ng/mL and her CRP level was 2.0 mg/L. Transthoracic echocardiography (TTE) showed the normal left ventricular size and significantly reduced left ventricular systolic function. The left ventricular ejection fraction (LVEF) was 15%. Chest X-ray revealed severe interstitial and alveolar oedema (Figure 1a). The patient was administered propylthiouracil, esmolol, dopamine, furosemide, and morphine. The patient’s condition was then exacerbated; non-invasive mechanical ventilation was used, and she was transferred to the ICU. She was started on continuous renal replacement therapy with epinephrine and norepinephrine infusion to support myotonic and vasopressin. Over the next few hours, despite efforts to maintain tissue perfusion, the patient’s condition worsened. Her vital signs (HR: 158 bpm, SPO2: 96%, and BP: 94/54 mm Hg) remained unstable despite high dose of norepinephrine (2.0 µg/kg/min), adrenaline (1.0 µg/kg/min), and dopamine (20 µg/kg/min) with ventilator support (FIO2: 100% and PEEP: 15 cm H2O). Blood gas analysis showed severe hyperlacticaemia and metabolic acidosis (pH: 7.300, Lac: 3.2 mmol/L, and BE: −10.0 mmol/L). Echocardiography revealed that the EF and global ventricular wall motion were much worse than before. PICCO showed severely low cardiac output and hyperpyrexia (T: 40.1°C, CI: 1.67, SI: 10.9, SVRI: 2,437, and EVLWI: 7.8). She was considered to be having hyperthyroidism crisis-induced cardiogenic shock. Mechanical ventilation was started, and the haemofiltration solution temperature was decreased to room temperature. Two hours later, the patient was still hyperpyrexic (40.3°C) and abruptly developed severe bradycardia; intermittent intravenous epinephrine was administered to maintain her heart rate.
Radiologic examination of the patient. (a) Chest X-ray showing serious interstitial and alveolar oedema. (b and c) Chest posteroanterior shows interstitial and alveolar oedema improved. (d) CT revealed a left suprarenal tumour of 5.8 cm × 5.7 cm in size with necrosis (white arrow).
As cardiocirculatory system collapse was anticipated and the underlying diagnosis was considered treatable, we decided to perform VA ECMO for this patient; she then underwent bedside percutaneous right femoral arterial (17 F) and venous (21 F) cannulation using the Seldinger technique VA ECMO (Figure 2). The patient was connected to a crystalloid-primed ECMO circuit (Maquet Cardiopulmonary AG, Germany). The initial ECMO flow rate was 3.83 L/min to maintain the mean blood pressure at 80 mm Hg with less than 10 mm Hg of pulse pressure. Continuous venovenous haemodiafiltration was discontinued. The ECMO temperature was set at 35°C to decrease hyperthermia. Less than 6 h later, the patient’s vital signs were almost stable (T: 38.2°C, HR: 95 bpm, SPO2: 99%, BP: 86/78 mm Hg, norepinephrine: 0.43 µg/kg/min, and adrenaline: 0.24 µg/kg/min) with continuous ECMO and inotropic agent and vasopressor support; her urine output was approximately 200 cc/h. Over the next 3 days after ECMO was established, repeat TTE showed gradual improvement in biventricular function. Norepinephrine and adrenaline were withdrawn on the third day (Figure 3). The patient’s cardiac condition remarkably improved. TTE on day 4 with an ECMO flow rate of 2.0 L/min revealed normal to hyperdynamic biventricular activity (LVEF: 55%) without any regional wall motion abnormalities, and she was weaned from ECMO later on the same day.
Patient with PCC treatment by VA ECMO.
Dynamic changes in blood pressure and dosage of vasopressors in the patient. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and dosages of norepinephrine (NE), epinephrine (E), dopamine (DA), and ECMO indicated. The dramatic cyclic blood pressure fluctuation during the catheter removed periods is particularly notable.
The patient’s blood pressure increased to 230/130 mm Hg when the catheter was removed; despite treatment with propofol and sufentanil at 200 mg/h and 50 µg separately, her blood pressure did improve and fluctuated from 130/60 mm Hg to 230/130 mm Hg in a short time. Intermittent sodium nitroprusside was required to control episodic hypertension; then, the diagnosis of phaeochromocytoma was suspected. Computed tomography revealed a left suprarenal tumour of 5.8 cm × 5.7 cm in size with central necrosis (Figure 1d). The vanillylmandelic acid concentration was 63.15 mg/24 h (normal value: 1.0–7.0 mg/24 h). A PCC diagnosis was made, and antihypertensive treatment with intravenous phentolamine and esmolol was gradually introduced in consultation with endocrinologists. The patient was transferred to the urology ward for preoperative preparation, and the tumour was eventually removed by laparoscopy. At last, pathology confirmed phaeochromocytoma (Figure 4). The patient was discharged from the hospital 1 week after the operation, and her blood pressure had returned to normal.
The histological diagnosis was pheochromocytoma of the adrenal medulla. (a) The tumor cells were distributed in nests under high magnification, with Sertoli cells and vascular sinuses visible around them. The tumor cells were polygonal and bubble-like with obvious nucleoli (HE ×400). (b) The expression of S-100 in the Sertoli cells (IHC ×400). (c) The expression of Syn in tumor cells (IHC ×400). (d) The expression of CgA in tumor cells (IHC ×400).
-
Informed consent: Informed consent has been obtained from all the individuals included in this study.
-
Ethical approval: The research related to human use has been complied with all the relevant national regulations, institutional policies, and in accordance with the tenets of the Helsinki Declaration, and has been approved by the Medical Ethics Committee of The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College).
3 Discussion
This phaeochromocytoma case demonstrates fulminant cardiomyopathy; however, the patient’s clinical manifestation gave no evidence of phaeochromocytoma diagnosis. Suspicion was first raised when the blood pressure fluctuated after the patient was weaned from ECMO and it was then confirmed by imaging and laboratory test. PCC has been defined as the release of large amounts of catecholamines resulting in severe organ dysfunction, especially haemodynamic instability and myocardial damage. PCC has been reported to mimic cardiomyopathy, myocardial infarction [3], pulmonary oedema, ARDS, sever haemoptysis [4], ischaemic or haemorrhagic stroke [5], acute kidney or liver injury, ischaemia of the ileus or bowel, metabolic disturbance, rhabdomyolysis, and thrombosis [6]. As far as we know, we are the first to report a patient with cardiogenic shock induced by PPC mimicking hyperthyroidism, which was successfully resuscitated by VA ECMO. Additionally, the patient recovered almost completely.
The rate of PCC misdiagnosis is very high. In a French multicentre cohort study [7] of PCC, among 34 PCC patients, 32 were under no suspicion of PCC before the complication leading to ICU admission; thus, the misdiagnosis rate was greater than 94%, and 8 of the 34 PCC patients were correctly diagnosed only during post-mortem. These eight patients died before the diagnosis was made [8]. In the current case, after the patient was admitted to the hospital, she rapidly developed fulminant cardiopulmonary failure without typical paroxysmal hypertension; although her thyroid hormone levels were not very high, and she did not show the characteristic clinical manifestations or thyroid gland sonographic findings of hyperthyroidism. High-quality research [9] has demonstrated that high thyroid hormone levels are not necessary to diagnose a thyroid storm, although with numerous doubtful points, which we chose to ignore. So, while “common things are common,” keeping an open mind regarding other possible differential diagnoses is essential in unusual cases [10]. Additionally, phaeochromocytoma should be considered in patients presenting with severe hemodynamic instability, particularly young patients [11].
An acute catecholamine crisis may be fatal before it is diagnosed [12]. Previous studies showed more than 85% mortality rate in the pheochromocytoma crisis [13]. The mortality rate of multisystem PCC was 45% based on a systematic review of 11 cases [14]. Numerous reports indicate that most patients with PCC crisis eventually die of heart failure and pulmonary oedema before diagnosis. And it does not respond to conventional treatment. Therefore, ECMO may be a lifesaving measure in these patients. Pheochromocytoma-related refractory cardiogenic shock requiring ECMO support has been reported by Haake et al. [15] and Suh et al. [16]. Previous reports have shown that ECMO, as an auxiliary means of cardiac resuscitation, can also achieve good results in patients with cardiac arrest [17]. Once ECMO is established, patients tend to improve quickly in a short time; it enables the use of alpha-blockers and fluid resuscitation, a contraindication because of the sustained hypotension and poor heart function. Therefore, this combination of hypotension and pathologic impairment treatment should achieve sustainable medical control in most cases. Mechanical circulatory support has a 92% survival rate of type B crisis. However, the control group had a 56% mortality rate, as described by Whitelaw et al. [18]. Since 2008, there have been frequent reports of the successful use of such circulatory support, as in the paper by Chao et al. [19] titled “Pheochromocytoma crisis is an absolute indication for ECMO.”
4 Conclusion
PCC mimics many conditions and is thus a masked killer. The misdiagnosis ratio was very high. For patients with unexplained cardiovascular impairment, especially in younger patients, we should consider the PCC.
-
Funding information: The authors state no funding involved.
-
Author contributions: X.Q.J., the corresponding author, was responsible for the conceptualization of the study and the revision and approval of this manuscript. Q.C.X. and T.W. designed and drafted the manuscript, collected data, and were responsible for its accuracy. All authors contributed to the data analysis and interpretation. All authors read and approved the final manuscript.
-
Conflict of interest: The authors state no conflict of interest.
-
Data availability statement: The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
References
[1] Abe I, Nomura M, Watanabe M, Shimada S, Kohno M, Matsuda Y, et al. Pheochromocytoma crisis caused by Campylobacter fetus. Int J Urol. 2012;19(5):465–7.10.1111/j.1442-2042.2011.02950.xSearch in Google Scholar PubMed
[2] Hudsmith JG, Thomas CE, Browne DA. Undiagnosed phaeochromocytoma mimicking severe preeclampsia in a pregnant woman at term. Int J Obstet Anesth. 2006;15(3):240–5.10.1016/j.ijoa.2005.11.003Search in Google Scholar PubMed
[3] Subramanyam S, Kreisberg RA. Pheochromocytoma: a cause of ST-segment elevation myocardial infarction, transient left ventricular dysfunction, and takotsubo cardiomyopathy. Endocr Pract. 2012 July 1;18(4):e77–80.10.4158/EP11346.CRSearch in Google Scholar PubMed
[4] Yoshida T, Ishihara H. Pheochromocytoma presenting as massive hemoptysis and acute respiratory failure. Am J Emerg Med. 2009 June 1;27(5):623–6.10.1016/j.ajem.2008.08.023Search in Google Scholar PubMed
[5] Kim MS, Muratore C, Snelling L, Mandelbaum DE, McEachern R, Mangray S, et al. Ischemic stroke and rhabdomyolysis in a 15-year-old girl with paraganglioma due to an SDHB exon 6 (Q214X) mutation. J Pediatr Endocrinol Metab. 2009 June 1;22(6):565–71.10.1515/JPEM.2009.22.6.565Search in Google Scholar PubMed
[6] Brauchlin AE, Rudiger A, Bachli EB, Schmid C, Maggiorini M. Portal vein thrombus and liver failure in a patient with pheochromocytoma crisis. Am J Emerg Med. 2009 June 1;27(5):630–3.10.1016/j.ajem.2008.09.002Search in Google Scholar PubMed
[7] Sauneuf B, Chudeau N, Champigneulle B, Bouffard C, Antona M, Pichon N, et al. Pheochromocytoma crisis in the ICU: a French multicenter cohort study with emphasis on rescue extracorporeal membrane oxygenation. Crit Care Med. 2017 July 1;45(7):e657–65.10.1097/CCM.0000000000002333Search in Google Scholar PubMed
[8] Cohen CD, Dent DM. Phaeochromocytoma and acute cardiovascular death (with special reference to myocardial infarction). Postgrad Med J. 1984 Feb 1;60(700):111–5.10.1136/pgmj.60.700.111Search in Google Scholar PubMed PubMed Central
[9] Akamizu T, Satoh T, Isozaki O, Suzuki A, Wakino S, Iburi T, et al. Diagnostic criteria, clinical features, and incidence of thyroid storm based on nationwide surveys. Thyroid. 2012 July 1;22(7):661–79.10.1089/thy.2011.0334Search in Google Scholar PubMed PubMed Central
[10] Mitchell L, Bellis F. Phaeochromocytoma – “the great mimic:” an unusual presentation. Emerg Med J. 2007 Sept 1;24(9):672–3.10.1136/emj.2007.049569Search in Google Scholar PubMed PubMed Central
[11] Flam B, Broome M, Frenckner B, Branstrom R, Bell M. Pheochromocytoma-induced inverted takotsubo-like cardiomyopathy leading to cardiogenic shock successfully treated with extracorporeal membrane oxygenation. J Intensive Care Med. 2015 Sept 1;30(6):365–72.10.1177/0885066614552992Search in Google Scholar PubMed
[12] Preuss J, Woenckhaus C, Schwesinger G, Madea B. Non-diagnosed pheochromocytoma as a cause of sudden death in a 49-year-old man: a case report with medico-legal implications. Forensic Sci Int. 2006 Jan 27;156(2–3):223–8.10.1016/j.forsciint.2005.05.025Search in Google Scholar PubMed
[13] Sauvage MR, Tulasne PA, Arnaud JP. Hypertensive accident in a surgical patient with unsuspected pheochromocytoma (author’s transl). Anesth Analg (Paris). 1979 March 1;36(3–4):155–8.Search in Google Scholar
[14] Uchida N, Ishiguro K, Suda T, Nishimura M. Pheochromocytoma multisystem crisis successfully treated by emergency surgery: report of a case. Surg Today. 2010 Oct 1;40(10):990–6.10.1007/s00595-009-4165-8Search in Google Scholar PubMed
[15] Haake H, Grun-Himmelmann K, Kania U, Trudzinski F, Lepper PM, Vom DJ. Treatment of an uncommon case of a cardiogenic shock: simultaneous use of a VA-ECMO and an Impella-CP(R). Med Klin Intensivmed Notfmed. 2018 March 1;113(2):131–4.10.1007/s00063-017-0324-7Search in Google Scholar PubMed
[16] Suh IW, Lee CW, Kim YH, Hong MK, Lee JW, Kim JJ, et al. Catastrophic catecholamine-induced cardiomyopathy mimicking acute myocardial infarction, rescued by extracorporeal membrane oxygenation (ECMO) in pheochromocytoma. J Korean Med Sci. 2008 April 1;23(2):350–4.10.3346/jkms.2008.23.2.350Search in Google Scholar PubMed PubMed Central
[17] Tseng LJ, Yu HY, Wang CH, Chi NH, Huang SC, Chou HW, et al. Impact of age-adjusted Charlson comorbidity on hospital survival and short-term outcome of patients with extracorporeal cardiopulmonary resuscitation. J Clin Med. 2018 Sept 29;7(10):313.10.3390/jcm7100313Search in Google Scholar PubMed PubMed Central
[18] Whitelaw BC, Prague JK, Mustafa OG, Schulte KM, Hopkins PA, Gilbert JA, et al. Phaeochromocytoma [corrected] crisis. Clin Endocrinol (Oxf). 2014 2014 Jan 1;80(1):13–22.10.1111/cen.12324Search in Google Scholar PubMed
[19] Chao A, Yeh YC, Yen TS, Chen YS. Phaeochromocytoma crisis – a rare indication for extracorporeal membrane oxygenation. Anaesthesia. 2008 Jan 1;63(1):86–8.10.1111/j.1365-2044.2007.05251.xSearch in Google Scholar PubMed
© 2021 Tao Wang et al., published by De Gruyter
This work is licensed under the Creative Commons Attribution 4.0 International License.
Articles in the same Issue
- Biomedical Sciences
- Research progress on the mechanism of orexin in pain regulation in different brain regions
- Adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer
- Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
- Iris metastasis of diffuse large B-cell lymphoma misdiagnosed as primary angle-closure glaucoma: A case report and review of the literature
- LncRNA PVT1 promotes cervical cancer progression by sponging miR-503 to upregulate ARL2 expression
- Two new inflammatory markers related to the CURB-65 score for disease severity in patients with community-acquired pneumonia: The hypersensitive C-reactive protein to albumin ratio and fibrinogen to albumin ratio
- Circ_0091579 enhances the malignancy of hepatocellular carcinoma via miR-1287/PDK2 axis
- Silencing XIST mitigated lipopolysaccharide (LPS)-induced inflammatory injury in human lung fibroblast WI-38 cells through modulating miR-30b-5p/CCL16 axis and TLR4/NF-κB signaling pathway
- Protocatechuic acid attenuates cerebral aneurysm formation and progression by inhibiting TNF-alpha/Nrf-2/NF-kB-mediated inflammatory mechanisms in experimental rats
- ABCB1 polymorphism in clopidogrel-treated Montenegrin patients
- Metabolic profiling of fatty acids in Tripterygium wilfordii multiglucoside- and triptolide-induced liver-injured rats
- miR-338-3p inhibits cell growth, invasion, and EMT process in neuroblastoma through targeting MMP-2
- Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model
- Circ_WWC3 overexpression decelerates the progression of osteosarcoma by regulating miR-421/PDE7B axis
- Knockdown of TUG1 rescues cardiomyocyte hypertrophy through targeting the miR-497/MEF2C axis
- MiR-146b-3p protects against AR42J cell injury in cerulein-induced acute pancreatitis model through targeting Anxa2
- miR-299-3p suppresses cell progression and induces apoptosis by downregulating PAX3 in gastric cancer
- Diabetes and COVID-19
- Discovery of novel potential KIT inhibitors for the treatment of gastrointestinal stromal tumor
- TEAD4 is a novel independent predictor of prognosis in LGG patients with IDH mutation
- circTLK1 facilitates the proliferation and metastasis of renal cell carcinoma by regulating miR-495-3p/CBL axis
- microRNA-9-5p protects liver sinusoidal endothelial cell against oxygen glucose deprivation/reperfusion injury
- Long noncoding RNA TUG1 regulates degradation of chondrocyte extracellular matrix via miR-320c/MMP-13 axis in osteoarthritis
- Duodenal adenocarcinoma with skin metastasis as initial manifestation: A case report
- Effects of Loofah cylindrica extract on learning and memory ability, brain tissue morphology, and immune function of aging mice
- Recombinant Bacteroides fragilis enterotoxin-1 (rBFT-1) promotes proliferation of colorectal cancer via CCL3-related molecular pathways
- Blocking circ_UBR4 suppressed proliferation, migration, and cell cycle progression of human vascular smooth muscle cells in atherosclerosis
- Gene therapy in PIDs, hemoglobin, ocular, neurodegenerative, and hemophilia B disorders
- Downregulation of circ_0037655 impedes glioma formation and metastasis via the regulation of miR-1229-3p/ITGB8 axis
- Vitamin D deficiency and cardiovascular risk in type 2 diabetes population
- Circ_0013359 facilitates the tumorigenicity of melanoma by regulating miR-136-5p/RAB9A axis
- Mechanisms of circular RNA circ_0066147 on pancreatic cancer progression
- lncRNA myocardial infarction-associated transcript (MIAT) knockdown alleviates LPS-induced chondrocytes inflammatory injury via regulating miR-488-3p/sex determining region Y-related HMG-box 11 (SOX11) axis
- Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis
- Hyperhomocysteinemia exacerbates ischemia-reperfusion injury-induced acute kidney injury by mediating oxidative stress, DNA damage, JNK pathway, and apoptosis
- Potential prognostic markers and significant lncRNA–mRNA co-expression pairs in laryngeal squamous cell carcinoma
- Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development
- ADHFE1 is a correlative factor of patient survival in cancer
- The association of transcription factor Prox1 with the proliferation, migration, and invasion of lung cancer
- Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?
- Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide
- T cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homology
- Anti-obesity effect and mechanism of mesenchymal stem cells influence on obese mice
- Long noncoding RNA HULC contributes to paclitaxel resistance in ovarian cancer via miR-137/ITGB8 axis
- Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress
- Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning
- Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities
- Silencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis
- Successful extracorporeal membrane oxygenation resuscitation of patient with cardiogenic shock induced by phaeochromocytoma crisis mimicking hyperthyroidism: A case report
- Effects of miR-185-5p on replication of hepatitis C virus
- Lidocaine has antitumor effect on hepatocellular carcinoma via the circ_DYNC1H1/miR-520a-3p/USP14 axis
- Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report
- Multimodal magnetic resonance imaging analysis in the characteristics of Wilson’s disease: A case report and literature review
- Therapeutic potential of anticoagulant therapy in association with cytokine storm inhibition in severe cases of COVID-19: A case report
- Neoadjuvant immunotherapy combined with chemotherapy for locally advanced squamous cell lung carcinoma: A case report and literature review
- Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood–brain barrier during kainic acid-induced brain damage
- Inhibition of ADAM10 ameliorates doxorubicin-induced cardiac remodeling by suppressing N-cadherin cleavage
- Invasive ductal carcinoma and small lymphocytic lymphoma/chronic lymphocytic leukemia manifesting as a collision breast tumor: A case report and literature review
- Clonal diversity of the B cell receptor repertoire in patients with coronary in-stent restenosis and type 2 diabetes
- CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression
- WDR74 promotes proliferation and metastasis in colorectal cancer cells through regulating the Wnt/β-catenin signaling pathway
- Down-regulation of IGHG1 enhances Protoporphyrin IX accumulation and inhibits hemin biosynthesis in colorectal cancer by suppressing the MEK-FECH axis
- Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis
- Scutellarin-induced A549 cell apoptosis depends on activation of the transforming growth factor-β1/smad2/ROS/caspase-3 pathway
- lncRNA NEAT1 regulates CYP1A2 and influences steroid-induced necrosis
- A two-microRNA signature predicts the progression of male thyroid cancer
- Isolation of microglia from retinas of chronic ocular hypertensive rats
- Changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study
- Calcineurin Aβ gene knockdown inhibits transient outward potassium current ion channel remodeling in hypertrophic ventricular myocyte
- Aberrant expression of PI3K/AKT signaling is involved in apoptosis resistance of hepatocellular carcinoma
- Clinical significance of activated Wnt/β-catenin signaling in apoptosis inhibition of oral cancer
- circ_CHFR regulates ox-LDL-mediated cell proliferation, apoptosis, and EndoMT by miR-15a-5p/EGFR axis in human brain microvessel endothelial cells
- Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells’ maturation and function
- Ubiquitin-conjugating enzyme E2T promotes tumor stem cell characteristics and migration of cervical cancer cells by regulating the GRP78/FAK pathway
- Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso
- Protective effect of Lactobacillus-containing probiotics on intestinal mucosa of rats experiencing traumatic hemorrhagic shock
- Glucocorticoids induce osteonecrosis of the femoral head through the Hippo signaling pathway
- Endothelial cell-derived SSAO can increase MLC20 phosphorylation in VSMCs
- Downregulation of STOX1 is a novel prognostic biomarker for glioma patients
- miR-378a-3p regulates glioma cell chemosensitivity to cisplatin through IGF1R
- The molecular mechanisms underlying arecoline-induced cardiac fibrosis in rats
- TGF-β1-overexpressing mesenchymal stem cells reciprocally regulate Th17/Treg cells by regulating the expression of IFN-γ
- The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia
- Red blood cell distribution width-standard deviation but not red blood cell distribution width-coefficient of variation as a potential index for the diagnosis of iron-deficiency anemia in mid-pregnancy women
- Small cell neuroendocrine carcinoma expressing alpha fetoprotein in the endometrium
- Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers
- Molecular characterization and phylogenetic studies of Echinococcus granulosus and Taenia multiceps coenurus cysts in slaughtered sheep in Saudi Arabia
- ITGB5 mutation discovered in a Chinese family with blepharophimosis-ptosis-epicanthus inversus syndrome
- ACTB and GAPDH appear at multiple SDS-PAGE positions, thus not suitable as reference genes for determining protein loading in techniques like Western blotting
- Facilitation of mouse skin-derived precursor growth and yield by optimizing plating density
- 3,4-Dihydroxyphenylethanol ameliorates lipopolysaccharide-induced septic cardiac injury in a murine model
- Downregulation of PITX2 inhibits the proliferation and migration of liver cancer cells and induces cell apoptosis
- Expression of CDK9 in endometrial cancer tissues and its effect on the proliferation of HEC-1B
- Novel predictor of the occurrence of DKA in T1DM patients without infection: A combination of neutrophil/lymphocyte ratio and white blood cells
- Investigation of molecular regulation mechanism under the pathophysiology of subarachnoid hemorrhage
- miR-25-3p protects renal tubular epithelial cells from apoptosis induced by renal IRI by targeting DKK3
- Bioengineering and Biotechnology
- Green fabrication of Co and Co3O4 nanoparticles and their biomedical applications: A review
- Agriculture
- Effects of inorganic and organic selenium sources on the growth performance of broilers in China: A meta-analysis
- Crop-livestock integration practices, knowledge, and attitudes among smallholder farmers: Hedging against climate change-induced shocks in semi-arid Zimbabwe
- Food Science and Nutrition
- Effect of food processing on the antioxidant activity of flavones from Polygonatum odoratum (Mill.) Druce
- Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
- Diversity of microbiota in Slovak summer ewes’ cheese “Bryndza”
- Comparison between voltammetric detection methods for abalone-flavoring liquid
- Composition of low-molecular-weight glutenin subunits in common wheat (Triticum aestivum L.) and their effects on the rheological properties of dough
- Application of culture, PCR, and PacBio sequencing for determination of microbial composition of milk from subclinical mastitis dairy cows of smallholder farms
- Investigating microplastics and potentially toxic elements contamination in canned Tuna, Salmon, and Sardine fishes from Taif markets, KSA
- From bench to bar side: Evaluating the red wine storage lesion
- Establishment of an iodine model for prevention of iodine-excess-induced thyroid dysfunction in pregnant women
- Plant Sciences
- Characterization of GMPP from Dendrobium huoshanense yielding GDP-D-mannose
- Comparative analysis of the SPL gene family in five Rosaceae species: Fragaria vesca, Malus domestica, Prunus persica, Rubus occidentalis, and Pyrus pyrifolia
- Identification of leaf rust resistance genes Lr34 and Lr46 in common wheat (Triticum aestivum L. ssp. aestivum) lines of different origin using multiplex PCR
- Investigation of bioactivities of Taxus chinensis, Taxus cuspidata, and Taxus × media by gas chromatography-mass spectrometry
- Morphological structures and histochemistry of roots and shoots in Myricaria laxiflora (Tamaricaceae)
- Transcriptome analysis of resistance mechanism to potato wart disease
- In silico analysis of glycosyltransferase 2 family genes in duckweed (Spirodela polyrhiza) and its role in salt stress tolerance
- Comparative study on growth traits and ions regulation of zoysiagrasses under varied salinity treatments
- Role of MS1 homolog Ntms1 gene of tobacco infertility
- Biological characteristics and fungicide sensitivity of Pyricularia variabilis
- In silico/computational analysis of mevalonate pyrophosphate decarboxylase gene families in Campanulids
- Identification of novel drought-responsive miRNA regulatory network of drought stress response in common vetch (Vicia sativa)
- How photoautotrophy, photomixotrophy, and ventilation affect the stomata and fluorescence emission of pistachios rootstock?
- Apoplastic histochemical features of plant root walls that may facilitate ion uptake and retention
- Ecology and Environmental Sciences
- The impact of sewage sludge on the fungal communities in the rhizosphere and roots of barley and on barley yield
- Domestication of wild animals may provide a springboard for rapid variation of coronavirus
- Response of benthic invertebrate assemblages to seasonal and habitat condition in the Wewe River, Ashanti region (Ghana)
- Molecular record for the first authentication of Isaria cicadae from Vietnam
- Twig biomass allocation of Betula platyphylla in different habitats in Wudalianchi Volcano, northeast China
- Animal Sciences
- Supplementation of probiotics in water beneficial growth performance, carcass traits, immune function, and antioxidant capacity in broiler chickens
- Predators of the giant pine scale, Marchalina hellenica (Gennadius 1883; Hemiptera: Marchalinidae), out of its natural range in Turkey
- Honey in wound healing: An updated review
- NONMMUT140591.1 may serve as a ceRNA to regulate Gata5 in UT-B knockout-induced cardiac conduction block
- Radiotherapy for the treatment of pulmonary hydatidosis in sheep
- Retraction
- Retraction of “Long non-coding RNA TUG1 knockdown hinders the tumorigenesis of multiple myeloma by regulating microRNA-34a-5p/NOTCH1 signaling pathway”
- Special Issue on Reuse of Agro-Industrial By-Products
- An effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli
- Special Issue on Computing and Artificial Techniques for Life Science Applications - Part II
- Relationship of Gensini score with retinal vessel diameter and arteriovenous ratio in senile CHD
- Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits
- Establishment of the New Zealand white rabbit animal model of fatty keratopathy associated with corneal neovascularization
- lncRNA MALAT1/miR-143 axis is a potential biomarker for in-stent restenosis and is involved in the multiplication of vascular smooth muscle cells
Articles in the same Issue
- Biomedical Sciences
- Research progress on the mechanism of orexin in pain regulation in different brain regions
- Adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer
- Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
- Iris metastasis of diffuse large B-cell lymphoma misdiagnosed as primary angle-closure glaucoma: A case report and review of the literature
- LncRNA PVT1 promotes cervical cancer progression by sponging miR-503 to upregulate ARL2 expression
- Two new inflammatory markers related to the CURB-65 score for disease severity in patients with community-acquired pneumonia: The hypersensitive C-reactive protein to albumin ratio and fibrinogen to albumin ratio
- Circ_0091579 enhances the malignancy of hepatocellular carcinoma via miR-1287/PDK2 axis
- Silencing XIST mitigated lipopolysaccharide (LPS)-induced inflammatory injury in human lung fibroblast WI-38 cells through modulating miR-30b-5p/CCL16 axis and TLR4/NF-κB signaling pathway
- Protocatechuic acid attenuates cerebral aneurysm formation and progression by inhibiting TNF-alpha/Nrf-2/NF-kB-mediated inflammatory mechanisms in experimental rats
- ABCB1 polymorphism in clopidogrel-treated Montenegrin patients
- Metabolic profiling of fatty acids in Tripterygium wilfordii multiglucoside- and triptolide-induced liver-injured rats
- miR-338-3p inhibits cell growth, invasion, and EMT process in neuroblastoma through targeting MMP-2
- Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model
- Circ_WWC3 overexpression decelerates the progression of osteosarcoma by regulating miR-421/PDE7B axis
- Knockdown of TUG1 rescues cardiomyocyte hypertrophy through targeting the miR-497/MEF2C axis
- MiR-146b-3p protects against AR42J cell injury in cerulein-induced acute pancreatitis model through targeting Anxa2
- miR-299-3p suppresses cell progression and induces apoptosis by downregulating PAX3 in gastric cancer
- Diabetes and COVID-19
- Discovery of novel potential KIT inhibitors for the treatment of gastrointestinal stromal tumor
- TEAD4 is a novel independent predictor of prognosis in LGG patients with IDH mutation
- circTLK1 facilitates the proliferation and metastasis of renal cell carcinoma by regulating miR-495-3p/CBL axis
- microRNA-9-5p protects liver sinusoidal endothelial cell against oxygen glucose deprivation/reperfusion injury
- Long noncoding RNA TUG1 regulates degradation of chondrocyte extracellular matrix via miR-320c/MMP-13 axis in osteoarthritis
- Duodenal adenocarcinoma with skin metastasis as initial manifestation: A case report
- Effects of Loofah cylindrica extract on learning and memory ability, brain tissue morphology, and immune function of aging mice
- Recombinant Bacteroides fragilis enterotoxin-1 (rBFT-1) promotes proliferation of colorectal cancer via CCL3-related molecular pathways
- Blocking circ_UBR4 suppressed proliferation, migration, and cell cycle progression of human vascular smooth muscle cells in atherosclerosis
- Gene therapy in PIDs, hemoglobin, ocular, neurodegenerative, and hemophilia B disorders
- Downregulation of circ_0037655 impedes glioma formation and metastasis via the regulation of miR-1229-3p/ITGB8 axis
- Vitamin D deficiency and cardiovascular risk in type 2 diabetes population
- Circ_0013359 facilitates the tumorigenicity of melanoma by regulating miR-136-5p/RAB9A axis
- Mechanisms of circular RNA circ_0066147 on pancreatic cancer progression
- lncRNA myocardial infarction-associated transcript (MIAT) knockdown alleviates LPS-induced chondrocytes inflammatory injury via regulating miR-488-3p/sex determining region Y-related HMG-box 11 (SOX11) axis
- Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis
- Hyperhomocysteinemia exacerbates ischemia-reperfusion injury-induced acute kidney injury by mediating oxidative stress, DNA damage, JNK pathway, and apoptosis
- Potential prognostic markers and significant lncRNA–mRNA co-expression pairs in laryngeal squamous cell carcinoma
- Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development
- ADHFE1 is a correlative factor of patient survival in cancer
- The association of transcription factor Prox1 with the proliferation, migration, and invasion of lung cancer
- Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?
- Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide
- T cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homology
- Anti-obesity effect and mechanism of mesenchymal stem cells influence on obese mice
- Long noncoding RNA HULC contributes to paclitaxel resistance in ovarian cancer via miR-137/ITGB8 axis
- Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress
- Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning
- Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities
- Silencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis
- Successful extracorporeal membrane oxygenation resuscitation of patient with cardiogenic shock induced by phaeochromocytoma crisis mimicking hyperthyroidism: A case report
- Effects of miR-185-5p on replication of hepatitis C virus
- Lidocaine has antitumor effect on hepatocellular carcinoma via the circ_DYNC1H1/miR-520a-3p/USP14 axis
- Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report
- Multimodal magnetic resonance imaging analysis in the characteristics of Wilson’s disease: A case report and literature review
- Therapeutic potential of anticoagulant therapy in association with cytokine storm inhibition in severe cases of COVID-19: A case report
- Neoadjuvant immunotherapy combined with chemotherapy for locally advanced squamous cell lung carcinoma: A case report and literature review
- Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood–brain barrier during kainic acid-induced brain damage
- Inhibition of ADAM10 ameliorates doxorubicin-induced cardiac remodeling by suppressing N-cadherin cleavage
- Invasive ductal carcinoma and small lymphocytic lymphoma/chronic lymphocytic leukemia manifesting as a collision breast tumor: A case report and literature review
- Clonal diversity of the B cell receptor repertoire in patients with coronary in-stent restenosis and type 2 diabetes
- CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression
- WDR74 promotes proliferation and metastasis in colorectal cancer cells through regulating the Wnt/β-catenin signaling pathway
- Down-regulation of IGHG1 enhances Protoporphyrin IX accumulation and inhibits hemin biosynthesis in colorectal cancer by suppressing the MEK-FECH axis
- Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis
- Scutellarin-induced A549 cell apoptosis depends on activation of the transforming growth factor-β1/smad2/ROS/caspase-3 pathway
- lncRNA NEAT1 regulates CYP1A2 and influences steroid-induced necrosis
- A two-microRNA signature predicts the progression of male thyroid cancer
- Isolation of microglia from retinas of chronic ocular hypertensive rats
- Changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study
- Calcineurin Aβ gene knockdown inhibits transient outward potassium current ion channel remodeling in hypertrophic ventricular myocyte
- Aberrant expression of PI3K/AKT signaling is involved in apoptosis resistance of hepatocellular carcinoma
- Clinical significance of activated Wnt/β-catenin signaling in apoptosis inhibition of oral cancer
- circ_CHFR regulates ox-LDL-mediated cell proliferation, apoptosis, and EndoMT by miR-15a-5p/EGFR axis in human brain microvessel endothelial cells
- Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells’ maturation and function
- Ubiquitin-conjugating enzyme E2T promotes tumor stem cell characteristics and migration of cervical cancer cells by regulating the GRP78/FAK pathway
- Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso
- Protective effect of Lactobacillus-containing probiotics on intestinal mucosa of rats experiencing traumatic hemorrhagic shock
- Glucocorticoids induce osteonecrosis of the femoral head through the Hippo signaling pathway
- Endothelial cell-derived SSAO can increase MLC20 phosphorylation in VSMCs
- Downregulation of STOX1 is a novel prognostic biomarker for glioma patients
- miR-378a-3p regulates glioma cell chemosensitivity to cisplatin through IGF1R
- The molecular mechanisms underlying arecoline-induced cardiac fibrosis in rats
- TGF-β1-overexpressing mesenchymal stem cells reciprocally regulate Th17/Treg cells by regulating the expression of IFN-γ
- The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia
- Red blood cell distribution width-standard deviation but not red blood cell distribution width-coefficient of variation as a potential index for the diagnosis of iron-deficiency anemia in mid-pregnancy women
- Small cell neuroendocrine carcinoma expressing alpha fetoprotein in the endometrium
- Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers
- Molecular characterization and phylogenetic studies of Echinococcus granulosus and Taenia multiceps coenurus cysts in slaughtered sheep in Saudi Arabia
- ITGB5 mutation discovered in a Chinese family with blepharophimosis-ptosis-epicanthus inversus syndrome
- ACTB and GAPDH appear at multiple SDS-PAGE positions, thus not suitable as reference genes for determining protein loading in techniques like Western blotting
- Facilitation of mouse skin-derived precursor growth and yield by optimizing plating density
- 3,4-Dihydroxyphenylethanol ameliorates lipopolysaccharide-induced septic cardiac injury in a murine model
- Downregulation of PITX2 inhibits the proliferation and migration of liver cancer cells and induces cell apoptosis
- Expression of CDK9 in endometrial cancer tissues and its effect on the proliferation of HEC-1B
- Novel predictor of the occurrence of DKA in T1DM patients without infection: A combination of neutrophil/lymphocyte ratio and white blood cells
- Investigation of molecular regulation mechanism under the pathophysiology of subarachnoid hemorrhage
- miR-25-3p protects renal tubular epithelial cells from apoptosis induced by renal IRI by targeting DKK3
- Bioengineering and Biotechnology
- Green fabrication of Co and Co3O4 nanoparticles and their biomedical applications: A review
- Agriculture
- Effects of inorganic and organic selenium sources on the growth performance of broilers in China: A meta-analysis
- Crop-livestock integration practices, knowledge, and attitudes among smallholder farmers: Hedging against climate change-induced shocks in semi-arid Zimbabwe
- Food Science and Nutrition
- Effect of food processing on the antioxidant activity of flavones from Polygonatum odoratum (Mill.) Druce
- Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
- Diversity of microbiota in Slovak summer ewes’ cheese “Bryndza”
- Comparison between voltammetric detection methods for abalone-flavoring liquid
- Composition of low-molecular-weight glutenin subunits in common wheat (Triticum aestivum L.) and their effects on the rheological properties of dough
- Application of culture, PCR, and PacBio sequencing for determination of microbial composition of milk from subclinical mastitis dairy cows of smallholder farms
- Investigating microplastics and potentially toxic elements contamination in canned Tuna, Salmon, and Sardine fishes from Taif markets, KSA
- From bench to bar side: Evaluating the red wine storage lesion
- Establishment of an iodine model for prevention of iodine-excess-induced thyroid dysfunction in pregnant women
- Plant Sciences
- Characterization of GMPP from Dendrobium huoshanense yielding GDP-D-mannose
- Comparative analysis of the SPL gene family in five Rosaceae species: Fragaria vesca, Malus domestica, Prunus persica, Rubus occidentalis, and Pyrus pyrifolia
- Identification of leaf rust resistance genes Lr34 and Lr46 in common wheat (Triticum aestivum L. ssp. aestivum) lines of different origin using multiplex PCR
- Investigation of bioactivities of Taxus chinensis, Taxus cuspidata, and Taxus × media by gas chromatography-mass spectrometry
- Morphological structures and histochemistry of roots and shoots in Myricaria laxiflora (Tamaricaceae)
- Transcriptome analysis of resistance mechanism to potato wart disease
- In silico analysis of glycosyltransferase 2 family genes in duckweed (Spirodela polyrhiza) and its role in salt stress tolerance
- Comparative study on growth traits and ions regulation of zoysiagrasses under varied salinity treatments
- Role of MS1 homolog Ntms1 gene of tobacco infertility
- Biological characteristics and fungicide sensitivity of Pyricularia variabilis
- In silico/computational analysis of mevalonate pyrophosphate decarboxylase gene families in Campanulids
- Identification of novel drought-responsive miRNA regulatory network of drought stress response in common vetch (Vicia sativa)
- How photoautotrophy, photomixotrophy, and ventilation affect the stomata and fluorescence emission of pistachios rootstock?
- Apoplastic histochemical features of plant root walls that may facilitate ion uptake and retention
- Ecology and Environmental Sciences
- The impact of sewage sludge on the fungal communities in the rhizosphere and roots of barley and on barley yield
- Domestication of wild animals may provide a springboard for rapid variation of coronavirus
- Response of benthic invertebrate assemblages to seasonal and habitat condition in the Wewe River, Ashanti region (Ghana)
- Molecular record for the first authentication of Isaria cicadae from Vietnam
- Twig biomass allocation of Betula platyphylla in different habitats in Wudalianchi Volcano, northeast China
- Animal Sciences
- Supplementation of probiotics in water beneficial growth performance, carcass traits, immune function, and antioxidant capacity in broiler chickens
- Predators of the giant pine scale, Marchalina hellenica (Gennadius 1883; Hemiptera: Marchalinidae), out of its natural range in Turkey
- Honey in wound healing: An updated review
- NONMMUT140591.1 may serve as a ceRNA to regulate Gata5 in UT-B knockout-induced cardiac conduction block
- Radiotherapy for the treatment of pulmonary hydatidosis in sheep
- Retraction
- Retraction of “Long non-coding RNA TUG1 knockdown hinders the tumorigenesis of multiple myeloma by regulating microRNA-34a-5p/NOTCH1 signaling pathway”
- Special Issue on Reuse of Agro-Industrial By-Products
- An effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli
- Special Issue on Computing and Artificial Techniques for Life Science Applications - Part II
- Relationship of Gensini score with retinal vessel diameter and arteriovenous ratio in senile CHD
- Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits
- Establishment of the New Zealand white rabbit animal model of fatty keratopathy associated with corneal neovascularization
- lncRNA MALAT1/miR-143 axis is a potential biomarker for in-stent restenosis and is involved in the multiplication of vascular smooth muscle cells
