Home Neoadjuvant immunotherapy combined with chemotherapy for locally advanced squamous cell lung carcinoma: A case report and literature review
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Neoadjuvant immunotherapy combined with chemotherapy for locally advanced squamous cell lung carcinoma: A case report and literature review

  • Yuan Zheng , Wei Zhu , Xinjie Huang , Dongqun Lin and Yu Lin EMAIL logo
Published/Copyright: August 25, 2021
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Open Life Sciences
From the journal Open Life Sciences Volume 16 Issue 1

Abstract

The benefit of immunochemotherapy in treating resectable locally advanced non-small cell lung cancer (NSCLC) is not well established. Here, we report a case of resectable stage III NSCLC treated with neoadjuvant immunotherapy combined with chemotherapy before surgery. A 61 years old man was admitted to our hospital due to paroxysmal cough and was diagnosed as squamous cell carcinoma T4N2M0 in the upper lobe of the right lung, which was locally advanced and resectable. He was treated with 3 courses of paclitaxel 250 mg intravenous (IV), carboplatin 0.65 g IV, and durvalumab 620 mg IV followed by thoracoscopic upper lobectomy and lymph node dissection. There was considerable regression of the tumor before surgery, and the patient achieved a complete pathological response after surgery. Our case study demonstrates the benefit of durvalumab and chemotherapy in the treatment of resectable locally advanced NSCLC.

Keywords: durvalumab; chemotherapy; neoadjuvant immunotherapy; locally advanced resectable NSCLC; case report

1 Introduction

Lung cancer is the leading cause of cancer-related mortality in both men and women worldwide [1,2,3]. The standard treatment options for lung cancer include surgery, radiation therapy, chemotherapy, targeted therapy, and immunotherapy [4]. Surgical resection is the potential treatment option for lung cancer at early stages, whereas multidisciplinary approaches are used during advanced stages [5,6]. Around one-third of the patients diagnosed with lung cancer would have reached stage III, locally advanced disease, when diagnosed with non-small cell lung cancer (NSCLC) [7]. There was heterogeneity in the 5-year survival rate of stage III NSLC with only 36% in stage IIIA, while with 26% in stage IIIB [8]. Postoperative recurrence and metastasis are the main reasons for the low 5-year survival rate in patients with stage III NSCLC [9].

Despite curative resection in patients with NSCLC, 30–70% of patients will experience relapse resulting in death [6,10]. For locally advanced NSCLC, perioperative neoadjuvant therapy and adjuvant therapy are the better treatment choices to improve the prognosis of patients with surgery [2,6,11]. Multimodal approaches such as neoadjuvant chemotherapy, surgery, adjuvant chemotherapy, and radiotherapy are recommended to manage patients with resectable locally advanced NSCLC patients [8]. The survival rate was comparatively higher in NSCLC patients treated with multimodal approaches as compared to patients treated with surgery alone [8,12]. Immunotherapy and targeted therapy are currently new treatment options for NSCLC with positive treatment outcomes [3,8,13,14]. PACIFIC study showed that immunotherapy (durvalumab) combined with radiotherapy can significantly improve the long-term survival rate in patients with unresectable stage III lung cancer, thus becoming a practice-changing study and led to FDA approval [15]. However, there is no enough evidence-based data for the treatment of patients with stage III resectable NSCLC. A phase II multicenter exploratory study reported complete pathological response (CPR) in 71% of the patients, suggesting that immunotherapy combined with chemotherapy might provide positive treatment outcomes as neoadjuvant therapy in patients with resectable stage IIIA NSCLC [16]. However, no studies are evaluating the efficacy of neoadjuvant durvalumab + chemotherapy in resectable stage IIIA NSCLC prior to surgery to our knowledge, and hence, this case is unique. Here, we report and discuss a case of resectable stage III NSCLC treated with neoadjuvant immunotherapy combined with chemotherapy.

2 Case presentation

A 61 years old man (body weight: 62 kg; performance score (PS) score: 0–1) was admitted to our hospital on April 10, 2020, due to paroxysmal cough for 6 months. There was no complaint of having expectoration, hemoptysis, chest pain, hot flashes, and night sweats. The patient had a paroxysmal cough for 6 months, and he left it undiagnosed. On April 1, 2020, the patient underwent chest computed tomography (CT) examination as suggested by a local hospital physician. The CT scan reported a space of about 7.9 cm × 6.7 cm × 6.0 cm in the right upper lobe of the lungs. He was admitted to our hospital for treatment. He was a heavy smoker (20 cigarettes per day for 40 years) with no family history of cancer. The patient’s medical report during admission showed that the case was diagnosed as lung cancer [17].

On physical examination during admission, there was no swelling of superficial lymph nodes in the whole province. During chest examination, the respiratory sounds of the right upper lung were diminished, and the respiratory sounds of the other parts of the lungs were clear. No dry and wet rales were found in both lungs. The thetumor marker levels in the serum were neuron-specific enolase (NSE) 12.5 ng/mL, squamous cell carcinoma antigen (SCC Ag) 1.7 ng/mL, and cytokeratin 19 fragments 15.8 ng/mL. On April 13, 2020, a chest CT examination showed bronchial obstruction in the right upper lobe surrounded with soft tissue mass, with a size of about 7.9 cm × 6.7 cm × 6.0 cm (Figure 1). Based on the diagnostic assessment, this condition was considered a central type of lung cancer in the right upper lobe, with suspected atelectasis of the right upper lobe. Multiple lymph nodes in the right hilar and mediastinum (2R, 4R areas) were enlarged, and the enhanced scan showed slight enhancement. No metastatic lesions were observed during whole-body bone imaging, brain magnetic resonance imaging, adrenal color Doppler ultrasound, cervical lymph node color Doppler ultrasound, and liver color Doppler ultrasound. Fiberoptic bronchoscopy also revealed a bronchial obstruction in the right upper lobe of the lung (Figure 2a and b). Histopathological examination of the tumor in the upper lobe of the right lung showed a squamous cell carcinoma (Figure 2c and d). Immunohistochemistry assay was TTF-1 (−), p63 (+), CD5/6 (+), P40 (+), and CK7 (−). Hence, the patient was diagnosed with locally advanced lung carcinoma T4N2M0 in the upper lobe of the right lung.

Figure 1 Chest CT scan of the right upper lobe of the bronchus. The right upper lobe bronchus was occluded and the surrounding soft tissue mass was about 7.9 cm × 6.7 cm × 6.0 cm.
Figure 1

Chest CT scan of the right upper lobe of the bronchus. The right upper lobe bronchus was occluded and the surrounding soft tissue mass was about 7.9 cm × 6.7 cm × 6.0 cm.

Figure 2 Images of fiberoptic bronchoscopy and histopathology. (a and b) Obstruction of the right upper bronchial lobe. (c and d) Histopathology of fibrobronchoscopy showed squamous cell carcinoma. Immunohistochemistry: TTF-1 (−), p63 (+), CD5/6 (+), P40 (+), and CK7 (−).
Figure 2

Images of fiberoptic bronchoscopy and histopathology. (a and b) Obstruction of the right upper bronchial lobe. (c and d) Histopathology of fibrobronchoscopy showed squamous cell carcinoma. Immunohistochemistry: TTF-1 (−), p63 (+), CD5/6 (+), P40 (+), and CK7 (−).

Sleeve resection and lymph node dissection or neoadjuvant chemotherapy plus sleeve resection or radical radiotherapy was suggested to the patient. Based on the patient and his family’s consent, neoadjuvant immunotherapy combined with chemotherapy before surgery was considered. The first course of treatment was paclitaxel 250 mg intravenous (IV) + carboplatin 0.65 g IV and durvalumab 620 mg IV was given along with chemotherapy. On May 13, 2020, during re-examining the tumor markers, NSE was 13.8 ng/mL, SCC Ag was 1.4 ng/mL, and the cytokeratin 19 fragment was 1.9 ng/mL. The second course of treatment was carried out on May 14, 2020.

On June 10, 2020, the patient was subjected to chest CT enhanced re-examination. The CT scan showed the presence of bronchial stenosis and occlusion in the right upper lobe along with soft tissue mass shadow with a size of about 5.0 cm × 3.2 cm × 2.8 cm (Figure 3). The upper lobe of the right lung expanded than before, multiple lymph nodes in the right hilar and mediastinum (2R, 4R) increased, enhanced scan slightly strengthened, decreased, and shrunk compared with the previous scan. The third course of treatment was started on June 11, 2020. On July 8, 2020, the tumor marker levels were NSE 22.8 ng/mL, SCC Ag 0.8 ng/mL, and cytokeratin 19 fragments 3.1 ng/mL. Chest CT enhanced scan showed right upper lobe bronchial obstruction along with soft tissue mass shadow with a size of about 4.2 cm × 2.6 cm × 2.2 cm. The lesion was smaller, and the necrosis was more extensive than before. Multiple lymph nodes in the right hilar and mediastinum (2R, 4R) were enlarged and slightly enhanced on an enhanced scan, which was nearly the same as before.

Figure 3 Images of chest CT enhanced scan. (a,b) Bronchial stenosis and occlusion in the right upper lobe of the lung. (c,d) Histopathology of enhanced CT showed soft tissue mass shadow, the size was about 4.2 cm × 2.6 cm × 2.2 cm, the lesion was smaller and the necrotic area was larger compared to previous scan.
Figure 3

Images of chest CT enhanced scan. (a,b) Bronchial stenosis and occlusion in the right upper lobe of the lung. (c,d) Histopathology of enhanced CT showed soft tissue mass shadow, the size was about 4.2 cm × 2.6 cm × 2.2 cm, the lesion was smaller and the necrotic area was larger compared to previous scan.

The clinical efficacy evaluation performed on July 9, 2020, with fiberoptic bronchoscopy showed that after treatment with neoadjuvant immunotherapy and chemotherapy, the right upper lobe of the right lung, the bronchus of the right upper lobe, was unobstructed, and tracheobronchitis occurred (Figure 4a and b). In addition, a biopsy at the opening of segmental bronchus showed chronic inflammation of bronchial mucosa with no cancer.

Figure 4 Images of fiberoptic bronchoscopy and histopathology post-treatment. (a and b) Right upper lobe bronchus unobstructed, tracheobronchial bronchitis. (c and d) Histopathology of the tumor after surgery showed necrosis, histiocyte reaction, cholesterol crystal, inflammatory cell reaction under a microscope, and no residual tumor cells.
Figure 4

Images of fiberoptic bronchoscopy and histopathology post-treatment. (a and b) Right upper lobe bronchus unobstructed, tracheobronchial bronchitis. (c and d) Histopathology of the tumor after surgery showed necrosis, histiocyte reaction, cholesterol crystal, inflammatory cell reaction under a microscope, and no residual tumor cells.

After considerable tumor regression, thoracoscopic upper lobectomy and lymph node dissections were performed on July 14, 2020. During the surgery, the tumor subsided >1 cm distal to the bronchial opening of the right upper lobe. No cancer was observed during the surgery. On postoperative pathological reports, the size of the lung tissue was 12 cm × 10 cm × 5.5 cm, and the size of the tumor bed was 3 cm × 2 cm × 2 cm. Under a microscope, necrosis, histiocyte reaction, cholesterol crystal, and inflammatory cell reaction were observed. No residual tumor cells were found, in line with the post-treatment reaction (Figure 4c and d). Immunohistochemistry showed CK (−), CD68 (histiocyte +), and p63 (−). No cancer cells were observed in the bronchial stump.

  1. Informed consent: Informed consent has been obtained from all individuals included in this study.

  2. Ethical approval: The research related to human use has been complied with all the relevant national regulations, institutional policies and in accordance with the tenets of the Helsinki Declaration, and has been approved by the author's institutional review board or equivalent committee.

3 Discussion

This case report describes a case with resectable NSCLC treated with neoadjuvant chemotherapy (paclitaxel + carboplatin) + immunotherapy (durvalumab) followed by surgery.

Neoadjuvant chemotherapy combined with durvalumab achieved a satisfactory CPR demonstrating preliminary promise for this treatment strategy. These findings are consistent with the preliminary results of previous studies [16,18,19,20]. Furthermore, in a single-arm, phase I trial with neoadjuvant nivolumab before pulmonary resection in patients with resectable NSCLC (N = 22), the major pathological response (MPR) in the resected tumor was 45%, and recurrence-free survival was 73% after 18 months of surgery [18]. Hence, neoadjuvant nivolumab monotherapy was feasible and safe in patients with resectable early NSCLC and provided clinical evidence for further research.

Further, a few more studies were carried out to explore the effect of immunotherapy combined with chemotherapy at neoadjuvant settings [16,19,20]. An open-label, multicenter, single-arm phase 2 trial (NADIM trial) from Spain evaluated the efficacy of neoadjuvant chemotherapy (paclitaxel + carboplatin) plus nivolumab immunotherapy in patients with resectable stage IIIA NSCLC (N = 46) before surgery [16,19]. Around 83% of the patients had MPR, 71% of the patients achieved CPR, and tumor downstaging was observed in 90% of the patients after neoadjuvant treatment with immunotherapy plus chemotherapy [19]. The recent results of the NADIM trial showed PFS in 77.1% of the patients at 24 months of follow-up without any adverse event associated with surgery delay or death [16]. Yet another open-label, multicenter, single-arm, phase 2 trial from the USA evaluated the efficacy of immunotherapy + chemotherapy (atezolizumab, with carboplatin and nab-paclitaxel) as a neoadjuvant treatment before surgical resection in patients with resectable stage IB–IIIA NSCLC (N = 30) [20]. A high proportion of the patients (57%) achieved MPR during 12.9 months of median follow-up period with manageable adverse events. However, no studies are evaluating durvalumab in the neoadjuvant setting for NSLC to our knowledge. Hence, our case study added evidence for the chances of a cure for a potentially lethal locally advanced NSCLC by choosing neoadjuvant durvalumab + chemotherapy for the treatment. However, there is no standard preoperative neoadjuvant treatment course, and the treatment course of two to three cycles has been selected based on the previous studies.

In phase 3 PACIFIC trial, patients with stage III unresectable NSCLC treated with durvalumab in adjuvant settings showed significantly longer progression-free survival and overall survival than patients treated with placebo [7,15]. PACIFIC trial changed the management of stage III NSCLC establishing durvalumab as a standard of care in these patients [21]. However, there is no sufficient evidence on the efficacy of durvalumab + chemotherapy as neoadjuvant treatment in patients with resectable stage III NSCLC. The ongoing trials investigating the efficacy of neoadjuvant durvalumab in stage III NSCLC are yet to publish the final results (NCT02572843, NCT03800134). Hence, our case study provides early clinical evidence for achieving CPR in a patient with resectable stage III NSCLC on treating with neoadjuvant immunotherapy (durvalumab) combined with chemotherapy before surgery.

After considerable regression of the tumor in the patient, we opted for thoracoscopic upper lobectomy and lymph node dissection as the pulmonary edema was mild and the separation of tissue space was not difficult. In the neoadjuvant chemotherapy era, sleeve resection or lobectomy plus bronchoplasty was a reasonable surgical plan in the case of tumor growth and infiltration to the bronchial orifice before neoadjuvant therapy. At present, there is no definite conclusion about the clinical scope of lobectomy. However, in this case, we performed routine lobectomy and final pathological examination of the frozen bronchial resection edge. As the resected bronchial margin was negative for the tumor, we did not perform sleeve resection of the upper lung.

Further, there is no clear guidance in clinical practice for postoperative adjuvant treatment in patients with resectable stage III NSCLC. However, based on the study NADIM trial, we can consider immunoadjuvant therapy for 1 year after surgery or conventional adjuvant chemotherapy for 4 courses [16].

Further, based on the results of preliminary studies and our case study, it is still unclear whether neoadjuvant immunotherapy combined with chemotherapy can improve long-term patient prognosis. Hence, long follow-up results of these studies are warranted to confirm the efficacy and safety of neoadjuvant immunotherapy combined with chemotherapy in patients with resectable stage III NSCLC.

4 Conclusion

In this study, patients with resectable stage III NSCLC treated with neoadjuvant chemoimmunotherapy achieved a complete pathological response, thus providing clinical evidence for future research. However, advanced phase 3 studies with long-term follow-up are imperative to provide further evidence for the chances of cure for a potentially lethal locally advanced resectable NSCLC.

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  1. Funding information: The authors state no funding involved.

  2. Author contributions: Y.Z., Y.L., and D.L: conceptualization of the study. W.Z. and X.H.: data acquisition. Y.Z., W.Z., X.H., D.L, and Y.L.: manuscript preparation. Y.Z., W.Z., X.H., D.L, and Y.L.: manuscript revision. All authors have read and approved the final manuscript.

  3. Conflict of interest: The authors state no conflict of interest.

  4. Data availability statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

[1] Postmus PE, Kerr KM, Oudkerk M, Senan S, Waller DA, Vansteenkiste J, et al. Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2017 Jul;28:iv1–21.10.1093/annonc/mdx222Search in Google Scholar PubMed

[2] Yeh J, Marrone KA, Forde PM. Neoadjuvant and consolidation immuno-oncology therapy in stage III non-small cell lung cancer. J Thorac Dis. 2018 Feb;10(Suppl 3):S451–9.10.21037/jtd.2018.01.109Search in Google Scholar PubMed PubMed Central

[3] Indini A, Rijavec E, Bareggi C, Grossi F. Novel treatment strategies for early-stage lung cancer: the oncologist’s perspective. J Thorac Dis. 2020 Jun;12(6):3390–8.10.21037/jtd.2020.02.46Search in Google Scholar PubMed PubMed Central

[4] Lemjabbar-Alaoui H, Hassan O, Yang Y-W, Buchanan P. Lung cancer: biology and treatment options. Biochim Biophys Acta. 2015 Dec;1856(2):189–210.10.1016/j.bbcan.2015.08.002Search in Google Scholar PubMed PubMed Central

[5] Lackey A, Donington JS. Surgical management of lung cancer. Semin Intervent Radiol. 2013 Jun;30(2):133–40.10.1055/s-0033-1342954Search in Google Scholar PubMed PubMed Central

[6] Uramoto H, Tanaka F. Recurrence after surgery in patients with NSCLC. Transl Lung Cancer Res. 2014 Aug;3(4):242–9.Search in Google Scholar

[7] Antonia SJ, Villegas A, Daniel D, Vicente D, Murakami S, Hui R, et al. Durvalumab after chemoradiotherapy in stage III non-small-cell lung cancer. N Engl J Med. 2017 Nov 16;377(20):1919–29.10.1056/NEJMoa1709937Search in Google Scholar PubMed

[8] Huber RM, De Ruysscher D, Hoffmann H, Reu S, Tufman A. Interdisciplinary multimodality management of stage III non-small cell lung cancer. Eur Respir Rev. 2019;28(152):190024. 10.1183/16000617.0024-2019.Search in Google Scholar PubMed

[9] Ma L, Qiu B, Zhang J, Li Q-W, Wang B, Zhang X-H, et al. Survival and prognostic factors of non-small cell lung cancer patients with postoperative locoregional recurrence treated with radical radiotherapy. Chin J Cancer. 2017 Dec 11;36(1):93.10.1186/s40880-017-0261-0Search in Google Scholar PubMed PubMed Central

[10] Yoon SM, Shaikh T, Hallman M. Therapeutic management options for stage III non-small cell lung cancer. World J Clin Oncol. 2017 Feb 10;8(1):1–20.10.5306/wjco.v8.i1.1Search in Google Scholar PubMed PubMed Central

[11] Wozniak AJ, Gadgeel SM. Adjuvant therapy for resected non-small cell lung cancer. Ther Adv Med Oncol. 2009 Sep;1(2):109–18.10.1177/1758834009338634Search in Google Scholar PubMed PubMed Central

[12] Song W-A, Zhou N-K, Wang W, Chu X-Y, Liang C-Y, Tian X-D, et al. Survival benefit of neoadjuvant chemotherapy in non-small cell lung cancer: an updated meta-analysis of 13 randomized control trials. J Thorac Oncol. 2010 Apr;5(4):510–6.10.1097/JTO.0b013e3181cd3345Search in Google Scholar

[13] Ren S, Wang C, Shen J, Zhu C. Neoadjuvant immunotherapy with resectable non-small cell lung cancer: recent advances and future challenges. J Thorac Dis. 2020 Apr;12(4):1615–20.10.21037/jtd.2020.03.44Search in Google Scholar

[14] Uprety D, Mandrekar SJ, Wigle D, Roden AC, Adjei AA. Neoadjuvant immunotherapy for NSCLC: current concepts and future approaches. J Thorac Oncol. 2020 Aug 1;15(8):1281–97.10.1016/j.jtho.2020.05.020Search in Google Scholar

[15] Antonia SJ, Villegas A, Daniel D, Vicente D, Murakami S, Hui R, et al. Overall survival with durvalumab after chemoradiotherapy in stage III NSCLC. N Engl J Med. 2018 Dec 13;379(24):2342–50.10.1056/NEJMoa1809697Search in Google Scholar

[16] Provencio M, Nadal E, Insa A, García-Campelo MR, Casal-Rubio J, Dómine M, et al. Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial. Lancet Oncol. 2020 Nov 1;21(11):1413–22.10.1016/S1470-2045(20)30453-8Search in Google Scholar

[17] “WMA – The World Medical Association-Declaration of Helsinki.” The World Medical Association. www.wma.net/what-we-do/medical-ethics/declaration-of-helsinki/Search in Google Scholar

[18] Bott MJ, Yang SC, Park BJ, Adusumilli PS, Rusch VW, Isbell JM, et al. Initial results of pulmonary resection following neoadjuvant nivolumab in patients with resectable non-small cell lung cancer. J Thorac Cardiovasc Surg. 2019 Jul;158(1):269–76.10.1016/j.jtcvs.2018.11.124Search in Google Scholar

[19] Provencio M, Nadal E, Insa A, Garcia-Campelo R, Casal Rubio J, Domine M, et al. Neoadjuvant chemoimmunotherapy for the treatment of stage IIIA resectable non-small-cell lung cancer (NSCLC): a phase II multicenter exploratory study — final data of patients who underwent surgical assessment. JCO. 2019 May 20;37(15_suppl):8509–9.10.1200/JCO.2019.37.15_suppl.8509Search in Google Scholar

[20] Shu CA, Gainor JF, Awad MM, Chiuzan C, Grigg CM, Pabani A, et al. Neoadjuvant atezolizumab and chemotherapy in patients with resectable non-small-cell lung cancer: an open-label, multicentre, single-arm, phase 2 trial. Lancet Oncol. 2020 Jun;21(6):786–95.10.1016/S1470-2045(20)30140-6Search in Google Scholar

[21] Gray JE, Villegas A, Daniel D, Vicente D, Murakami S, Hui R, et al. Three-year overall survival with durvalumab after chemoradiotherapy in stage III NSCLC — update from PACIFIC. J Thorac Oncol. 2020 Feb;15(2):288–93.10.1016/j.jtho.2019.10.002Search in Google Scholar PubMed PubMed Central

Received: 2021-03-03
Revised: 2021-07-05
Accepted: 2021-07-13
Published Online: 2021-08-25

© 2021 Yuan Zheng et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  83. TGF-β1-overexpressing mesenchymal stem cells reciprocally regulate Th17/Treg cells by regulating the expression of IFN-γ
  84. The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia
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  86. Small cell neuroendocrine carcinoma expressing alpha fetoprotein in the endometrium
  87. Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers
  88. Molecular characterization and phylogenetic studies of Echinococcus granulosus and Taenia multiceps coenurus cysts in slaughtered sheep in Saudi Arabia
  89. ITGB5 mutation discovered in a Chinese family with blepharophimosis-ptosis-epicanthus inversus syndrome
  90. ACTB and GAPDH appear at multiple SDS-PAGE positions, thus not suitable as reference genes for determining protein loading in techniques like Western blotting
  91. Facilitation of mouse skin-derived precursor growth and yield by optimizing plating density
  92. 3,4-Dihydroxyphenylethanol ameliorates lipopolysaccharide-induced septic cardiac injury in a murine model
  93. Downregulation of PITX2 inhibits the proliferation and migration of liver cancer cells and induces cell apoptosis
  94. Expression of CDK9 in endometrial cancer tissues and its effect on the proliferation of HEC-1B
  95. Novel predictor of the occurrence of DKA in T1DM patients without infection: A combination of neutrophil/lymphocyte ratio and white blood cells
  96. Investigation of molecular regulation mechanism under the pathophysiology of subarachnoid hemorrhage
  97. miR-25-3p protects renal tubular epithelial cells from apoptosis induced by renal IRI by targeting DKK3
  98. Bioengineering and Biotechnology
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  103. Food Science and Nutrition
  104. Effect of food processing on the antioxidant activity of flavones from Polygonatum odoratum (Mill.) Druce
  105. Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China
  106. Diversity of microbiota in Slovak summer ewes’ cheese “Bryndza”
  107. Comparison between voltammetric detection methods for abalone-flavoring liquid
  108. Composition of low-molecular-weight glutenin subunits in common wheat (Triticum aestivum L.) and their effects on the rheological properties of dough
  109. Application of culture, PCR, and PacBio sequencing for determination of microbial composition of milk from subclinical mastitis dairy cows of smallholder farms
  110. Investigating microplastics and potentially toxic elements contamination in canned Tuna, Salmon, and Sardine fishes from Taif markets, KSA
  111. From bench to bar side: Evaluating the red wine storage lesion
  112. Establishment of an iodine model for prevention of iodine-excess-induced thyroid dysfunction in pregnant women
  113. Plant Sciences
  114. Characterization of GMPP from Dendrobium huoshanense yielding GDP-D-mannose
  115. Comparative analysis of the SPL gene family in five Rosaceae species: Fragaria vesca, Malus domestica, Prunus persica, Rubus occidentalis, and Pyrus pyrifolia
  116. Identification of leaf rust resistance genes Lr34 and Lr46 in common wheat (Triticum aestivum L. ssp. aestivum) lines of different origin using multiplex PCR
  117. Investigation of bioactivities of Taxus chinensis, Taxus cuspidata, and Taxus × media by gas chromatography-mass spectrometry
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  120. In silico analysis of glycosyltransferase 2 family genes in duckweed (Spirodela polyrhiza) and its role in salt stress tolerance
  121. Comparative study on growth traits and ions regulation of zoysiagrasses under varied salinity treatments
  122. Role of MS1 homolog Ntms1 gene of tobacco infertility
  123. Biological characteristics and fungicide sensitivity of Pyricularia variabilis
  124. In silico/computational analysis of mevalonate pyrophosphate decarboxylase gene families in Campanulids
  125. Identification of novel drought-responsive miRNA regulatory network of drought stress response in common vetch (Vicia sativa)
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  127. Apoplastic histochemical features of plant root walls that may facilitate ion uptake and retention
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  132. Molecular record for the first authentication of Isaria cicadae from Vietnam
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  136. Predators of the giant pine scale, Marchalina hellenica (Gennadius 1883; Hemiptera: Marchalinidae), out of its natural range in Turkey
  137. Honey in wound healing: An updated review
  138. NONMMUT140591.1 may serve as a ceRNA to regulate Gata5 in UT-B knockout-induced cardiac conduction block
  139. Radiotherapy for the treatment of pulmonary hydatidosis in sheep
  140. Retraction
  141. Retraction of “Long non-coding RNA TUG1 knockdown hinders the tumorigenesis of multiple myeloma by regulating microRNA-34a-5p/NOTCH1 signaling pathway”
  142. Special Issue on Reuse of Agro-Industrial By-Products
  143. An effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli
  144. Special Issue on Computing and Artificial Techniques for Life Science Applications - Part II
  145. Relationship of Gensini score with retinal vessel diameter and arteriovenous ratio in senile CHD
  146. Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits
  147. Establishment of the New Zealand white rabbit animal model of fatty keratopathy associated with corneal neovascularization
  148. lncRNA MALAT1/miR-143 axis is a potential biomarker for in-stent restenosis and is involved in the multiplication of vascular smooth muscle cells
https://doi.org/10.1515/biol-2021-0083
Keywords for this article
durvalumab; chemotherapy; neoadjuvant immunotherapy; locally advanced resectable NSCLC; case report
Creative Commons
BY 4.0

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  142. Special Issue on Reuse of Agro-Industrial By-Products
  143. An effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli
  144. Special Issue on Computing and Artificial Techniques for Life Science Applications - Part II
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  146. Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits
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  148. lncRNA MALAT1/miR-143 axis is a potential biomarker for in-stent restenosis and is involved in the multiplication of vascular smooth muscle cells
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