Home The crystal structure of 6,6′-(((2-(dimethylamino)ethyl)azanediyl)bis(methylene))bis(2-chloro-4-methyl phenolate-κ4N,N′,O,O′)-(pyridine-2,6-dicarboxylato-N,O,O′)-titanium(IV), C27H27Cl2N3O6Ti
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The crystal structure of 6,6′-(((2-(dimethylamino)ethyl)azanediyl)bis(methylene))bis(2-chloro-4-methyl phenolate-κ4N,N′,O,O′)-(pyridine-2,6-dicarboxylato-N,O,O′)-titanium(IV), C27H27Cl2N3O6Ti

  • Mingjun Yang and Canghai Wang ORCID logo EMAIL logo
Published/Copyright: July 26, 2023
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Zeitschrift für Kristallographie - New Crystal Structures
From the journal Zeitschrift für Kristallographie - New Crystal Structures Volume 238 Issue 5

Abstract

C27H27Cl2N3O6Ti, monoclinic, P21/c (no. 14), a = 11.609(4) Å, b = 21.476(7) Å, c = 13.504(4) Å, β = 109.881(9)°, V = 3166.2(18) Å3, Z = 4, Rgt(F) = 0.0623, wRref(F2) = 0.1945, T = 100(1) K.

CCDC no.: 2112802

The crystal structure is shown in the figure. Table 1 contains crystallographic data and Table 2 contains the list of the atoms including atomic coordinates and displacement parameters.

Table 1:

Data collection and handling.

Crystal: Red block
Size: 0.3 × 0.2 × 0.2 mm
Wavelength: Ga Kα radiation (1.34139 Å)
μ: 2.81 mm−1
Diffractometer, scan mode: Bruker APEX-II, φ and ω-scans
θmax, completeness: 55°, >99 %
N(hkl)measured, N(hkl)unique, Rint: 23,033, 6002, 0.066
Criterion for Iobs, N(hkl)gt: Iobs > 2σ(Iobs), 4698
N(param)refined: 356
Programs: Bruker programs [1], SHELX [2]
Table 2:

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2).

x y z Uiso*/Ueq
C1 0.2589 (2) 0.41131 (14) 0.8174 (2) 0.0413 (7)
C2 0.3402 (3) 0.42048 (14) 0.9208 (2) 0.0435 (7)
C3 0.2926 (3) 0.42919 (16) 1.0017 (2) 0.0532 (8)
H3 0.348018 0.434930 1.071360 0.064*
C4 0.1677 (3) 0.42984 (19) 0.9851 (2) 0.0633 (10)
C5 0.0867 (3) 0.42064 (19) 0.8821 (3) 0.0644 (10)
H5 0.000695 0.420952 0.867787 0.077*
C6 0.1342 (3) 0.41088 (16) 0.7998 (2) 0.0510 (8)
C7 0.1199 (4) 0.4385 (3) 1.0762 (3) 0.0917 (15)
H7A 0.175148 0.417763 1.139073 0.137*
H7B 0.037860 0.420228 1.057589 0.137*
H7C 0.115811 0.483012 1.090507 0.137*
C8 0.4753 (2) 0.42474 (15) 0.94311 (19) 0.0439 (7)
H8A 0.517396 0.421511 1.020145 0.053*
H8B 0.493940 0.466349 0.920889 0.053*
C9 0.6609 (3) 0.39059 (15) 0.9235 (2) 0.0447 (7)
H9A 0.694830 0.388457 1.001366 0.054*
H9B 0.669906 0.434097 0.903057 0.054*
C10 0.7376 (2) 0.34920 (15) 0.8797 (2) 0.0425 (7)
C11 0.7039 (2) 0.33838 (13) 0.7709 (2) 0.0382 (6)
C12 0.7837 (3) 0.30544 (14) 0.7338 (2) 0.0457 (7)
C13 0.8939 (3) 0.28190 (16) 0.8015 (3) 0.0585 (9)
H13 0.947585 0.260027 0.774094 0.070*
C14 0.9249 (3) 0.29054 (17) 0.9091 (3) 0.0623 (9)
C15 0.8474 (3) 0.32472 (16) 0.9473 (2) 0.0538 (8)
H15 0.869725 0.331561 1.020910 0.065*
C16 1.0448 (4) 0.2641 (2) 0.9861 (3) 0.0914 (15)
H16A 1.029690 0.222503 1.009085 0.137*
H16B 1.075312 0.291548 1.047451 0.137*
H16C 1.105818 0.261235 0.950954 0.137*
C17 0.5060 (3) 0.31383 (15) 0.9304 (2) 0.0490 (8)
H17A 0.426916 0.314909 0.943204 0.059*
H17B 0.571451 0.305748 0.998628 0.059*
C18 0.5034 (3) 0.26138 (16) 0.8555 (2) 0.0579 (9)
H18A 0.586964 0.254564 0.853492 0.069*
H18B 0.476780 0.222582 0.880909 0.069*
C19 0.2909 (3) 0.26161 (17) 0.7360 (3) 0.0637 (10)
H19A 0.281298 0.216764 0.744194 0.096*
H19B 0.238271 0.274685 0.665669 0.096*
H19C 0.267481 0.284190 0.789355 0.096*
C20 0.4551 (4) 0.23123 (17) 0.6761 (3) 0.0722 (11)
H20A 0.532782 0.244719 0.669400 0.108*
H20B 0.390922 0.231575 0.606624 0.108*
H20C 0.464224 0.188969 0.705133 0.108*
C21 0.3097 (2) 0.43033 (14) 0.47948 (18) 0.0373 (6)
C22 0.2624 (3) 0.47220 (18) 0.3973 (2) 0.0580 (9)
H22 0.209480 0.458273 0.330581 0.070*
C23 0.2932 (3) 0.53433 (17) 0.4139 (2) 0.0589 (9)
H23 0.261369 0.563687 0.358682 0.071*
C24 0.3712 (3) 0.55361 (15) 0.5122 (2) 0.0527 (8)
H24 0.394618 0.596058 0.524707 0.063*
C25 0.4138 (2) 0.50994 (13) 0.5909 (2) 0.0385 (6)
C26 0.2893 (3) 0.36183 (16) 0.4790 (2) 0.0441 (7)
C27 0.4965 (3) 0.52033 (14) 0.7018 (2) 0.0445 (7)
Cl1 0.03329 (7) 0.39840 (5) 0.67310 (6) 0.0735 (3)
Cl2 0.74555 (7) 0.29269 (4) 0.59838 (6) 0.0579 (3)
N1 0.5277 (2) 0.37574 (11) 0.88961 (16) 0.0377 (6)
N2 0.4201 (2) 0.27546 (11) 0.74950 (17) 0.0466 (6)
N3 0.38382 (19) 0.44974 (10) 0.57411 (15) 0.0348 (5)
O1 0.30213 (16) 0.40155 (9) 0.73775 (13) 0.0406 (5)
O2 0.59491 (15) 0.35878 (9) 0.70494 (13) 0.0371 (4)
O3 0.34693 (19) 0.33679 (9) 0.57077 (13) 0.0460 (5)
O4 0.2265 (2) 0.33369 (12) 0.40193 (15) 0.0704 (7)
O5 0.51578 (18) 0.46968 (9) 0.75692 (14) 0.0449 (5)
O6 0.5372 (3) 0.57168 (11) 0.73191 (19) 0.0760 (8)
Ti1 0.43975 (4) 0.38270 (2) 0.70437 (3) 0.03157 (19)

1 Source of materials

The ONON ligand L1: 6,6′-(((2-(dimethylamino)ethyl)azanediyl)bis(methylene))bis(2-chloro-4-methyl phenol) was prepared according to the general procedure for 24 h as a white solid in a yield of 86 % [3]. The corresponding [ONON]-type Ti(IV) chelate was synthesized according to reported method [4]. Under an N2 atmosphere, L1 (2.5 mmol, 1000 mg) was dissolved in anhydrous tetrahydrofuran (40 mL), Ti(OiPr)4 (2.5 mmol, 0.74 mL) was then added to the solution. The reaction was stirring at room temperature for 1 h, 2.6-dipicolinlic acid (Dipic) (2.5 mmol, 417.8 mg) was added and the reaction was continued stirring for 4 h while monitoring the reaction progress by TLC. Upon completion, [L1Ti(IV)(Dipic)] was separated by flash column chromatography (petroleum ether/ethyl acetate = 3/1 and dichloromethane/methanol = 10/1) to obtain a red solid (2.2 mmol, 1352.8 mg, 89 %). Suitable crystals for X-ray diffraction measurements were obtained by slow diffusion of n-hexane to a dichloromethane solution of [L1Ti(IV)(Dipic)] at room temperature.

2 Experimental details

H atoms bonded to C atoms were positioned geometrically with C–H = 0.95 Å (aromatic), 0.99 Å (methylene) and 0.98 Å (methyl) and refined in a riding mode [Uiso(H) = 1.2 UeqC (aromatic and methylene)], 1.5 UeqC(methyl).

3 Comment

Titanocene dichloride ([Cp2Ti(IV)Cl2], TDC) [5] and Budotitane ((bis-(1-phenyl-1,3-butanedione)Ti(IV)) [6] entered clinical trials as antitumor drugs, but eventually failed due to their insufficient aqueous stability. In recent years, Salan Ti(IV) alkoxyl complexes have been widely studied as alkene polymerization catalysts and antitumor drugs [7, 8]. As a second chelating ligand, [SalanTi(IV)(Dipic)] formed by Dipic not only has excellent anti-tumor activity in vitro and in vivo, but also significantly improves its aqueous stability [9]. Based on its excellent stability, its radioisotopic complex [45Ti][SalanTi(IV)Dipic] is allowed to be used as a PET probe [10] and could via sonogashira reaction introduced alkynyl to enhance antitumor activity [11]. The [ONON]-type ligand is similar with Salan but has a flexible pendant donor side arm having O, N, O atoms on the backbone with a N atom from the pending arm. Studies on the antitumor activity of [ONON] Ti bis-chelates are relatively limited, to the best of our knowledge only one study has reported its antitumor activity [4]. Reported in this article [L1Ti(IV)(Dipic)] showed excellent antitumor activity against Hep G2 and Hela S3 cell lines.

As shown in the Figure, the central Ti cation is seven-coordinated by three nitrogen atoms and four carboxylate oxygen atoms, forming a distorted penta-dentated bipyramidal geometry. The bond lengths of four Ti–O and three Ti–N are ranging from 1.847(2) to 2.085(2) Å and from 2.194(2) to 2.363(2) Å, respectively.

Corresponding author: Canghai Wang, College of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, Gansu, P.R. China, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: Natural Science Foundation of Gansu Province of China (Nos. 20JR5RA470).

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2023-04-07
Accepted: 2023-07-04
Published Online: 2023-07-26
Published in Print: 2023-10-26

© 2023 the author(s), published by De Gruyter, Berlin/Boston

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  58. Crystal structure of catena-poly[bis(μ2-azido-k2N:N′)-(nitrato-K2N:N′)-bis(1,10-phenanthroline-K2N:N′)samarium(III)], C24H16N11O3Sm
  59. Crystal structure of (Z)-2-(4-((5-bromopentyl)oxy)benzylidene)-4,5,6-trimethoxybenzofuran-3(2H)-one, C23H25BrO6
  60. Crystal structure of bis(3,5-dimethyl-1H-pyrazol-4-ammonium) tetrafluoroterephthate, 2[C5H10N3][C8F4O4]
  61. Crystal structure of 2-amino-4-(2-fluoro-4-(trifluoromethyl)phenyl)-9-methoxy-1,4,5,6-tetrahydrobenzo[h]quinazolin-3-ium chloride, C20H18ClF4N3O
  62. Crystal structure of 6-(pyridin-3-yl)-1,3,5-triazine-2,4-diamine-sebacic acid (2/1), C13H17N6O2
https://doi.org/10.1515/ncrs-2023-0168
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Articles in the same Issue

  1. Frontmatter
  2. New Crystal Structures
  3. The crystal structure of (N-([1,1′:4′,1″-terphenyl]-4,4′-diethyl)-2-(bis(pyridin-2-ylmethyl)amino)acetamide-κ4N,N,N″, O)tri(nitrato-kO, O′) samarium(III) - methanol - acetonitrile (1/1/1), C40H39SmN8O14
  4. The crystal structure of 6,6′-(((2-(dimethylamino)ethyl)azanediyl)bis(methylene))bis(2-chloro-4-methyl phenolate-κ4N,N′,O,O′)-(pyridine-2,6-dicarboxylato-N,O,O′)-titanium(IV), C27H27Cl2N3O6Ti
  5. N′-[(1E)-(4–Fluorophenyl)methylidene]adamantane-1-carbohydrazide, C18H21FN2O
  6. Crystal structure of 4-bromo-3-nitro-1H-pyrazole-5-carboxylic acid monohydrate, C4H2N3BrO4·H2O
  7. Crystal structure of dipyridine-k1N-tris(2,2,6,6-tetramethyl-5-oxohept-3-en-3-olato-k2O,O′)dysprosium(III), DyC43H67O6N2
  8. Crystal structure of cyclo[tetraiodido-bis{μ2-1-[(benzotriazol-1-yl)methyl]-1-H-1,3-(2-isopropyl-imidazol)-k2N:N}dicadmiun(II)], C26H30N10Cd2I4
  9. The crystal structure of tert-butyl (E)-3-(2-(benzylideneamino)phenyl)-1H-indole-1-carboxylate, C26H24N2O2
  10. The crystal structure of 4-(3-carboxy-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4- dihydroquinolin-7-yl)-2-methylpiperazin-1-ium 2,5-dihydroxybenzoate methanol solvate, C27H32FN3O9
  11. Crystal structure of (μ2-1-(4,4′-bipyridine-κ2N:N′)-bis[diaqua-(4-iodopyridine-2,6-dicarboxylato-κ3O,N,O′)–cobalt(II)], C24H20Co2I2N4O12
  12. The crystal structure of dimethyl 4,4′-(10,20-diphenylporphyrin-5,15-diyl)dibenzoate dichloromethane solvate, C49H36N4O4Cl2
  13. (E)-2-((E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-ylidene)hydrazine-1-carbothioamide C14H23N3S1
  14. The crystal structure of [1-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinolin-2(1H)-one], C16H12F3NO
  15. Crystal structure of (E)-2-amino-N′-((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene)benzohydrazide – dimethylformamide – water (1/1/2), C15H16N4O3·C3H7NO·2H2O
  16. Crystal structure of 3-(4-bromophenyl)-5-methyl-1H-pyrazole, C10H9BrN2
  17. Crystal structure of 1,10-phenanthrolinium bromide dihydrate, C12H9N2Br
  18. Crystal structure of N-(4′-chloro-[1,1′-biphenyl]-2-yl)formamide, C13H10ClNO
  19. The crystal structure of nitroterephthalic acid, C8H5NO6
  20. Crystal structure of (2-((4-bromo-2,6-dichlorophenyl)amino)phenyl) (morpholino)methanone, C17H15BrCl2N2O2
  21. Crystal structure of tetraaqua-bis(ethanol-κO)-tetrakis(μ2-trifluoroacetate-κ2O:O′)-bis(trifluoroacetate-κ2O)digadolinium(III) Gd2C16H20O18F18
  22. The crystal structure of dimethyl 4,4′-[10,20-bis(2,6-difluorophenyl)porphyrin-5,15-diyl]dibenzoate chloroform solvate, C50H32Cl6F4N4O4
  23. The crystal structure of N,N′-((nitroazanediyl)bis(methylene))diacetamide, C6H12O4N4
  24. The crystal structure of [bis(2,2′-bipyridine-6-carboxylato-κ3N,N,O)magnesium(II)]dihydrate, C22H18N4O6Mg
  25. Crystal structure of poly[diaqua-(bis(μ2-1,4-bis(imidazol-1-ylmethyl)benzene)-κ2N,N′] cobalt(II)-tetraqua-bis(1,4-bis(imidazol-1-ylmethyl)benzene)-κ1N)-cobalt(II) di(2,5-thiophenedicarboxylate) dihydrate, C68H76Co2N16O16S2
  26. Crystal structure of poly[chlorido-μ2-chlorido-(μ2-1-[(2-ethyl-4-methyl-1H-imidazol-1-yl)methyl]-1H-benzotriazole-κN:N’)cadmium(II)], C13H15CdN5Cl2
  27. The crystal structure of (4-hydroxybenzenesulfonate)-k1O-6,6′-((1E,1′E)- (ethane-1,2-diylbis(azaneylylidene))bis(methaneylylidene)) bis(2-methoxyphenol)-κ2N,N,μ2O,O,κ2O, O)-(methanol)-cobalt(II) sodium(I), C25H27CoN2NaO9S
  28. Crystal structure of (1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)(4-((2-methyl-6-(trifluoromethyl)pyrimidin-4-yl)amino)piperidin-1-yl)methanone, C17H18F6N6O
  29. Crystal structure of bis{[(cyclohexylimino)(phenylimino)-l5-(methyl)diethylazane-κ2N:N′]-(ethyl)-zinc(II)]}, C38H62N6Zn2
  30. Crystal structure of 2-[(4-bromobenzyl)thio]-5-(5-bromothiophen-2-yl)-1,3,4-oxadiazole, C13H8Br2N2OS2
  31. Crystal structure of 10-methoxy-7,11b,12,13-tetrahydro-6H-pyrazino [2′,3′:5,6]pyrazino[2,1-a]isoquinoline, C15H16N4O
  32. The crystal structure of 1-propyl-2-nitro-imidazole oxide, C6H9N3O3
  33. The crystal structure of 3-nitrobenzene-1,2-dicarboxylic acid–2-ethoxybenzamide (1/1), C17H16N2O8
  34. The structure of RUB-1, (C8H16N)6[B6Si48O108], a boron containing levyne-type zeolite, occluding N-methyl-quinuclidinium in the cage-like pores
  35. The crystal structure of diaqua-(naphthalene-4,5-dicarboxylate-1,8-dicarboxylic anhydride-κ1O)-(4′-(4-(1H-benzimidazolyl-1-yl)phenyl)-2,2′:6′,2″-terpyridine-κ3N,N′,N″)–manganese(II) dihydrate, C42H27MnN5O9·2H2O
  36. Crystal structure of 6,6′-((1E,1′E)-hydrazine-1,2-diylidenebis(methanylylidene))bis (3-(3-bromopropoxy)phenol), C20H22Br2N2O4
  37. The crystal structure of 3-(2-hydroxyphenyl)-4-phenyl-6-(p-tolyl)-2H-pyran-2-one, C24H18O3
  38. Crystal structure of bis(μ2-2-(1,5-dimethyl–3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino)methyl)phenolato-κ4O:O,N,O′)-(nitrato-κ2O,O′)dicobalt(II), C36H32Co2N8O4
  39. Synthesis and crystal structure of (3E,5S,10S,13S,14S,17Z)-17-ethylidene-10,13-dimethylhexadecahydro-3H-cyclopenta[α] phenanthren-3-one O-(4-fluorobenzoyl) oxime, C28H36FNO2
  40. The crystal structure of 4-aminiumbiphenyl benzenesulfonate, C18H17NO3S
  41. Synthesis and crystal structure of 1-(7-hydroxy-3-(4-hydroxy-3-nitrophenyl)-4-oxo-4H-chromen-8-yl)-N,N-dimethylmethanaminiumnitrate, C18H17N3O9
  42. Crystal structure of N-(Ar)-N′-(Ar′)-formamidine, C14H12Br2N2O
  43. The crystal structure of 4-(2,4-dichlorophenyl)-2-(4-fluorophenyl)-5-methyl-1H-imidazole, C16H11Cl2FN2
  44. Crystal structure of 1-(4–chlorophenyl)-4-benzoyl-3-methyl-1H-pyrazol-5-ol, C17H13ClN2O2
  45. The crystal structure of 5-amino-1-methyl-4-nitroimidazole, C4H6O2N4
  46. Crystal structure of 1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene-N,N′-bis(1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-1,3,2-diazaborol-2-yl)-l2-germenediamine, C63H94B2GeN8
  47. The crystal structure of (bromido, chlorido)-tricarbonyl-(5,5′-dimethyl-2,2′-bipyridine)-rhenium(I), C15H12Br0.2Cl0.8N2O3Re1
  48. Crystal structure of [N(E),N′(E)]-N,N′-(1,4-phenylenedimethylidyne)bis-3,5-bis(propan-2-yl)-1H-pyrazol-4-amine, C26H36N6
  49. The crystal structure of poly[2-(4-carboxypyridin-3-yl)terephthalpoly[diaqua-(μ4-2-(6-carboxylatopyridin-3-yl)terephthalato-κ5O,N:O′:O″,O‴)]) cadmium(II)] dihydrate, C28H20Cd3N2O16
  50. Crystal structure of [tetraaqua-bis((3-carboxy-5-(pyridin-4-yl)benzoate-κ1N)cobalt(II)] tetrahydrate, C26H32CoN2O16
  51. Crystal structure of bis(μ2-azido-κ2N:N)-tetrakis(azido-κ1N)-tetrakis(1,10-phenanthroline-κ2N,N′)dibismuth(III), C48H32N26Bi2
  52. Crystal structure of (Z)-N-(4-(4-(4-((4,5,6-trimethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)phenoxy)butoxy)phenyl)acetamide, C30H31NO8
  53. Crystal structure of poly[diaqua-(μ2-1,3-di(1H-imidazol-1-yl)propane-κ2N:N′)-bis(μ2-5-carboxybenzene-1,3-dicarboxylato-O,O′:O″)-aqua-di-zinc dihydrate solvate], C27H28N4O16Zn2
  54. Crystal structure of 2-(3,5,5-trimethylcyclohex-2-en-1-ylidene)malononitrile, C12H14N2
  55. Crystal structure of chlorido-(5-nitro-2-phenylpyridine-κ2N,C)-[(methylsulfinyl)methane-κ1S]platinum(II), C13H13ClN2O3PtS
  56. The crystal structure of the co-crystal 1,4-dioxane–4,6-bis(nitroimino)-1,3,5-triazinan-2-one(2/1), C11H19N7O9
  57. Crystal structure of [N(E),N′(E)]-N,N′-(1,4-phenylenedimethylidyne)bis-3,5-dimethyl-1H-pyrazol-4-amine di-methanol solvate, C18H20N6·2(CH3OH)
  58. Crystal structure of catena-poly[bis(μ2-azido-k2N:N′)-(nitrato-K2N:N′)-bis(1,10-phenanthroline-K2N:N′)samarium(III)], C24H16N11O3Sm
  59. Crystal structure of (Z)-2-(4-((5-bromopentyl)oxy)benzylidene)-4,5,6-trimethoxybenzofuran-3(2H)-one, C23H25BrO6
  60. Crystal structure of bis(3,5-dimethyl-1H-pyrazol-4-ammonium) tetrafluoroterephthate, 2[C5H10N3][C8F4O4]
  61. Crystal structure of 2-amino-4-(2-fluoro-4-(trifluoromethyl)phenyl)-9-methoxy-1,4,5,6-tetrahydrobenzo[h]quinazolin-3-ium chloride, C20H18ClF4N3O
  62. Crystal structure of 6-(pyridin-3-yl)-1,3,5-triazine-2,4-diamine-sebacic acid (2/1), C13H17N6O2
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