Home Moraxella lacunata infection accompanied by acute glomerulonephritis
Article Open Access

Moraxella lacunata infection accompanied by acute glomerulonephritis

  • Nami Sawada , Tamaki Morohashi , Tomokazu Mutoh , Tsukasa Kuwana , Junko Yamaguchi , Kosaku Kinoshita EMAIL logo , Ichiro Morioka and Hiroyuki Hao
Published/Copyright: October 1, 2020
Download Article (PDF)
Open Medicine
From the journal Open Medicine Volume 15 Issue 1

Abstract

Moraxella lacunata (M. lacunata) is a Gram-negative bacterium, which rarely causes serious infection. This is a rare case report of acute glomerulonephritis diagnosed by pathological findings in a child accompanied by M. lacunata infection. The patient showed hematuria, proteinuria and hyperkalemia requiring emergency hemodialysis. After hospitalization, M. lacunata bacteremia became apparent. Pathological findings showed an increase in glomerulus inflammatory cells and glomerular C3 deposition was observed in the renal tissue biopsy. Final diagnosis was endocapillary proliferative glomerulonephritis. Clinical reports of M. lacunata infection requiring emergency hemodialysis in children are rare. Previous reports have suggested that lowered immune competency with chronic kidney disease may be a risk factor associated with serious invasive cases of M. lacunata infection. However, detailed clinical laboratory data and pathological findings have not been identified in previous case reports. Our case directly indicated complement activity and acute glomerulonephritis with M. lacunata infection. Although there are various causes for acute glomerulonephritis, infection-related glomerulonephritis (IRGN) is an important concept. M. lacunata infection might have a potential risk for IRGN with dysregulation of complement activity leading to serious and invasive clinical conditions than previously considered.

Keywords: Moraxella lacunata; children; complement activity; hemodialysis; sepsis

1 Introduction

Moraxella lacunata (M. lacunata) is a Gram-negative bacterium found in healthy commensal flora of the upper respiratory tract. M. lacunata rarely causes infection such as conjunctivitis, keratitis endophthalmitis, endocarditis and septic arthritis [1,2]. M. lacunata usually responds to antibiotics such as beta-lactams, aminoglycosides and quinolones [2]. According to a review of previous case reports, cases of systemic M. lacunata infection with acute kidney injury requiring emergency hemodialysis are few [2]. Moreover, in the previous reports, detailed clinical information and pathology of kidney injury have not been clarified, and there are few reports on acute glomerulonephritis in child patients with M. lacunata infection. Consequently, this is considered to be a rare case report demonstrating clinical laboratory data and pathological findings of a patient with M. lacunata infection (infection-related glomerulonephritis [IRGN] [3,4]) in children. In addition, this case report includes a literature review of systemic M. lacunata infections with acute kidney injury.

2 Case report

This is a case of 12-year-old boy with no noteworthy medical history. Ten days before hospital admission, the patient experienced abdominal pain and diarrhea. A day before admission, enlarged lymph nodes that showed tenderness were observed on the right side of the neck. Palpebral edema, hematuria and hyperkalemia (serum potassium: 7.0 mmol/L) were diagnosed at the initial physical examination by the primary care doctor. The patient received a calcium gluconate (0.085 g) IV and three glucose–insulin infusion (40 mL of 50% glucose and 8 U of regular insulin) IVs. After these IV treatments, serum potassium level decreased to 5.8 mmol/L, temporarily. Symptoms of the respiratory tract such as pharyngitis were not observed and rapid antigen detection test for group A Streptococcus by throat swab was negative.

The patient visited the hospital emergency department due to kidney injury with recurrence of hyperkalemia. Serum sodium and potassium were 138 and 7.7 mmol/L, respectively. Tented T waves on his ECG and acute lymphadenitis in the neck were also observed. Blood pressure at hospital arrival was 165/93 mm Hg, pulse was 78 beats per minute and body temperature was 37.6°C on admission. On physical examination, bilateral eyelid edema and lymph node enlargement with tenderness in the right front area of the neck were observed. However, sore throat, skin lesions, abdominal tenderness, hepatosplenomegaly and bilateral inguinal lymphadenopathy were not observed. In addition, insect bites and signs of systemic infection were also not observed.

Laboratory data upon admission, as shown in Table 1, included white blood cell count: 12,700/μL; hemoglobin: 8.1 g/dL; and platelets: 3,16,000/μL. Blood urea nitrogen was 77.9 mg/dL and serum creatinine concentration was 1.15 mg/dL (the normal range of his age is 0.40–0.61 mg/dL). The patient was placed in the admitted intensive care unit (ICU) due to refractory hyperkalemia with acute kidney injury (estimated glomerular filtration rate was calculated to be 59 mL/min/1.73 m2 and urine output was <5 mL/h for the first 24 h with a median of 15 mL/h between 6 and 48 h after admission). Both Acute Kidney Injury Network and Kidney Disease: Improving Global Outcomes criteria indicated stage 2. A second rapid antigen detection test for group A Streptococcus by the throat swab was negative. Antistreptolysin-O (ASO) titre was 689 IU/mL (normal range < 300) and antistreptokinase (ASK) titre was 5,120 IU/mL (normal range <5,120).

Table 1

Laboratory data on admission

WBC (4.0–8.0 × 103/μL)12.7CRP (<0.2 mg/dL)0.78
Neurocyte (%)78.1Presepsin (<500 pg/mL)159
Lymphocyte (%)15.9Procalcitonin (<0.5 ng/mL)0.24
Monocyte (%)3.9FDP (<5 μg/mL)9.3
Eosinocyte (%)1.9D-dimmer (<1 μg/mL)4.90
RBC (4.5–5.5 × 106/μL)3.14Na (136–148 mmol/L)138
Hgb (14–17 g/dL)8.1K (3.6–5.0 mmol/L)7.7
Hct (40–50%)25.0Cl (98–109 mmol/L)109
Platelet (158–348 × 103/μL)316Ca (8.8–10.8 mg/dL)8.8
T-Bil (0.3–1.2 mg/dL)0.53P (2.4–4.5 mg/dL)5.5
D-Bil (0.05–0.4 mg/dL)0.14Mg (1.7–2.3 mg/dL)2.8
AST (8–38 U/L)20
ALT (4–44 U/L)10Urine analysis
LD (106–220 U/L)241Urine pH 5.5
ALP (117–335 U/L)390Urine gravity 1.010
G-GT (12–73 U/L)11Urine protein3+
CK (54–253 U/L)52Urine occult blood3+
TP (6.5–8.0 g/dL)7.4Urine sugar—
Albumin (3.8–5.3 g/dL)2.8
Blood sugar (70–110 mg/dL)87
UN (8–19 mg/dL)77.9
Creatinine (0.40–0.61 mg/dL)1.15

Other clinical data including immunological test data are listed in Table 2. Serum concentrations of complement (C) 3, C4 and 50% hemolytic complement activity (CH50) were 4 mg/dL (normal range: 73–138), 12 mg/dL (normal range: 11–31) and <10.0 U/mL (normal range: 30–45), respectively. Immunoglobulin values of IgG (normal range: 861–1,747 mg/dL), IgA (normal range: 93–393 mg/dL) and IgM (normal range: 33–83 mg/dL) were 2,649, 330 and 99 mg/dL, respectively. Other immunological tests for Sjögren’s syndrome, lupus erythematosus and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis were negative. Urine sediment contained white blood cells, and urine blood and urine protein were both 3+. A third rapid antigen detection test for group A Streptococcus by the throat swab on the second hospital day was also negative. Only normal commensal flora grew in the throat culture, and group A beta-hemolytic Streptococcus did not appear.

Table 2

Immunological test

IgG (861–1,747 mg/dL)2,649CMV IgGNegative
IgA ( 93–393 IU/L)330CMV IgMNegative
IgM (33–183 mg/dL)99EBV-VCA IgMNegative
C3 (73–138 mg/dL)4EBV-VCA IgGNegative
C4 (11–31 mg/dL)12Anti-GBM antibodyNegative
CH50 (30–45 U/mL)<10.0Anti-nuclear antibodyNegative
Anti-SS-A/B antibodyNegative
ASO (<300 IU/mL)Anti-dsDNA antibodyNegative
On adm689Anti-PR3-ANCA antibodyNegative
2 wks after adm922MPO-ANCA antibodyNegative
4 wks after adm369Anti-CCP antibodyNegative
12 wks after adm236Human parvovirus b19 antigenNegative
ASK (<5120 IU/mL) HBs antibodyNegative
On adm5,120HCV antibodyNegative
2 wks after adm5,120Treponema pallidumNegative
4 wks after admNAHIVNegative
12 wks after adm640FilariaNegative
MalariaNegative
T-SPOT testNegative

adm: admission; wks: weeks; NA: not available; C: complement; ASO: antistreptolysin‐O; ASK: antistreptokinase; HBs: hepatitis B surface; anti-SSA/B autoantibodies: anti-Sjögren’s-syndrome-related antigen A/B; GBM: glomerular basement membrane; Antineutrophil cytoplasmic antibodies (ANCA, MPO, PR3); anti-CCP: anti-cyclic citrullinated peptide; anti-dsDNA: anti-double stranded DNA; ANCA: antineutrophil cytoplasmic antibody; MPO: myeloperoxidase; PR3-ANCA: proteinase 3-antineutrophil cytoplasmic antibody; T-SPOT: a type of enzyme-linked immune absorbent spot (ELISpot) assay used for tuberculosis diagnosis, and belongs to the group of INF gamma release assays.

Antibiotic therapy (Ampicillin/Sulbactam: ABPC/SBT 3g q6hr) for acute lymphadenitis accompanied with leukocytosis was initiated. Emergency hemodialysis was performed for hyperkalemia showing tented T waves on the ECG. Hyperkalemia gradually improved after hemodialysis. Three days after admission, urine output exceeded 0.5 mL/kg/h and blood potassium level decreased to 4.7 mmoL/L (Table 3), so continuous hemodialysis was discontinued. However, body temperature increased to 40.0°C (serum white blood cell count was 28,200/μL, C-reactive protein [CRP] was 6.92 mg/dL, quick SOFA was 2; respiration rate was 24/min, heart rate was 132/min, and his consciousness level was lethargic). On day 4, M. lacunata was detected by two sets of blood cultures, which were collected on the third day during the fever. Consequently, M. lacunata bacteremia became apparent. M. lacunata infection was speculated to originate with lymphadenitis, as conjunctivitis, keratitis endophthalmitis, endocarditis and septic arthritis were ruled out according to other laboratory data and transesophageal echocardiography during clinical course. In addition, antibiotics were switched to Cefotaxime: CTX 1g q12hr on day 8.

Table 3

Trends of laboratory data after admission

Admission days123468101525
WBC (4.0–8.0 × 103/μL)12.711.211.528.214.211.49.17.67.2
CRP (<0.2 mg/dL)0.780.740.846.923.712.191.061.020.57
Platelet (158–348 × 103/μL)316289341297219225215387260
T-Bil (0.3–1.2 mg/dL)0.530.450.510.490.400.320.340.240.22
Creatinine (0.40–0.61 mg/dL)1.151.011.592.021.220.790.690.640.73
K (3.6–5.0 mmol/L)7.75.74.74.44.54.54.64.34.4
Admission days173090150270
C3 (73–138 mg/dL)4.07.044.072.074.079.0
CH50 (30–45 U/mL)1010.443.551.456.758.2

C: complement.

Percutaneous renal biopsy was performed on day 11 (Figure 1). Pathological findings indicated increased infiltration of inflammatory cells into the glomerular tuft and narrowing of the vascular lumen. Immunofluorescence studies were also performed for IgG, IgA, IgM, C3, C4 and C1q (Complement component 1q) antibodies. Glomerular C3 deposition (starry sky pattern) was observed, but IgG and other immunoglobulin depositions were not detected in the renal tissue biopsy by the fluorescent antibody method. Final pathological diagnosis was endocapillary proliferative glomerulonephritis and was clinically consistent with acute kidney injury.

The patient did not show any serologic evidence preceding streptococcal infection, however, sequential changes in serum ASO or ASK titre indicated a peak infection around 2 weeks after hospital admission and then gradually decreased during next 12 weeks (Table 2).

Figure 1 Pathological observation by percutaneous renal biopsy. (a) PAS stain. (b) Fluorescent antibody method. (c) Electronic microscope. According to pathological observation, glomerulus inflammatory cells infiltrating into the glomerular tuft increased. Glomerular C3 deposition (starry sky pattern) was observed by fluorescent antibody method. Electronic microscope finding of a portion of a glomerulus. Subepithelial dense deposit (hump; black arrow) and intramembranous deposits (white arrows) are shown. C3: complement 3.
Figure 1

Pathological observation by percutaneous renal biopsy. (a) PAS stain. (b) Fluorescent antibody method. (c) Electronic microscope. According to pathological observation, glomerulus inflammatory cells infiltrating into the glomerular tuft increased. Glomerular C3 deposition (starry sky pattern) was observed by fluorescent antibody method. Electronic microscope finding of a portion of a glomerulus. Subepithelial dense deposit (hump; black arrow) and intramembranous deposits (white arrows) are shown. C3: complement 3.

The patient was moved from ICU to the general ward and antibiotics were discontinued on day 15. Urine protein and hematuria were still positive on day 20, so oral administration of prednisolone (60 mg/day) was initiated and reduced to 30 mg/day on day 34, to 15 mg/day on day 48, to 5 mg/day on day 62 and was discontinued on day 76. C3 was gradually normalized on day 30 (Table 3). He was finally discharged on day 42 with good recovery, negative urine protein on day 96 and recovery of hematuria on day 162.

  1. Informed consent: Written informed consent was obtained from the patient’s family before hospital discharge for this case report.

3 Discussion

Previously, some clinical case reports on patients with M. lacunata infection have been published. Among these, three cases of chronic kidney disease (end-stage kidney disease [2], Lupus nephritis [5] and diabetic nephropathy [6]) with hemodialysis and one case of M. lacunata infectious arthritis with a nephrotic syndrome [7] were included. However, a clinical case where a patient who visited the hospital emergency due to acute kidney injury requiring emergency hemodialysis has not been reported. Our patient had no noteworthy medical history, such as chronic kidney disease, and was admitted with acute kidney injury. Moreover, M. lacunata infection became apparent after hospitalization. Previous case reports have considered that chronic kidney disease may be a risk factor associated with serious invasive cases of M. lacunata infection, suggesting immune suppression or activation of a complement pathway [5,8,9]. However, activation of a complement pathway has not been clinically proven and detailed laboratory data and pathological findings have not been provided in previous case reports. Our patient directly demonstrated activation of the complement pathway and was diagnosed with endocapillary proliferative glomerulonephritis. Sepsis-related acute kidney injury is commonly considered to affect renal vasoconstriction and progress to acute tubular necrosis [10]. According to pathological findings in this case, however, infiltration of inflammatory cells into the glomerular tuft with deposition of C3 was indicated and final pathological diagnosis was acute endocapillary proliferative glomerulonephritis accompanying M. lacunata infection. In this case, clinically low serum C3 could also be identified, which supports the hypothesis of previous case reports [5,8,9].

Acute glomerulonephritis develops from various causes and infections are an important cause in the concept of IRGN [3,4]. Hypocomplementemia is exhibited with IRGN, and C3 is depressed with or without depression of C4 [11]. In this case, symptoms of bacterial infection were present with depression of C3 when acute glomerulonephritis was diagnosed. As no clinical evidence of group A Streptococcus infection were observed in his past history, this case is considered to be clinically consistent with IRGN. Common cause of acute glomerulonephritis in children is now recognized as an immunologically mediated complication [12]. Initial clinical symptoms are a sore throat such as pharyngitis, edema and hematuria, and hypertension. These are typical symptoms for acute glomerulonephritis diagnosis. This case deteriorated into acute kidney injury requiring emergency hemodialysis in a 2-week clinical course. M. lacunata infection may carry the risk of dysregulation of complement activity, leading to serious and invasive clinical conditions which interact with each other to a greater extent than previously considered [1,2,7]. Although various bacteria may be the cause of IRGN and the fact that some genetic factors may affect IRGN have been considered [4], whether M. lacunata itself is a potential cause for IRGN remains unclear. However, it is of critical concern if M. lacunata infection could be a risk of IRGN, affecting the activation of the complement pathway.

Some reports have indicated that invasive case of M. lacunata infection is observed in patients with chronic disease, such as heart disease, arterial hypertension and chronic renal disease [1,2,5,7]. In general, Ampicillin/Sulbactam: ABPC/SBT or beta-lactam antibiotics Cephalosporin, such as Cefotaxime and Ceftriaxone, are effective for M. lacunata bacteria infection itself, except for beta-lactamase-producing M. lacunata [2,13]. The combination of aminoglycoside with β-lactam antibiotics is recommended for infective endocarditis of specific bacteria (Enterococcus and Staphylococcus in artificial valve patients) [14], and this combination antibiotics therapy may be useful in patients with infective endocarditis of M. lacunata as well [2,15]. Although dependent on any medical history of chronic disease or systemic complications, outcome of infection/bacteremia caused by M. lacunata itself is relatively favorable [2,15]. In our case, infectious symptoms promptly improved after antibiotic therapy, but additional treatment for renal dysfunction was needed. Rapid clinical evaluation to determine the presence of organ dysfunction is required in cases of serious invasive disease of M. lacunata bacteria infection in addition to antibiotic therapy.

In conclusion, this is a rare case report of M. lacunata infection with acute kidney injury requiring emergency hemodialysis, which was diagnosed as endocapillary proliferative glomerulonephritis. This also directly indicated clinically lowered immune competency in serious, invasive cases of M. lacunata infection.

N. Sawada and T. Morohashi contributed equally to this work

tel: +81-3-3972-8111, ext: 2800, 2826, fax: +81-3-5964-8037

  1. Conflict of interest: The authors confirm that there was no conflict of interest regarding this subject.

References

[1] Takahashi S, Murata K, Ozawa K, Yamada H, Kawakami H, Nakayama A, et al. Moraxella species: infectious microbes identified by use of time-of-flight mass spectrometry. Jpn J Ophthalmol. 2019;63:328–36. 10.1007/s10384-019-00669-4.Search in Google Scholar PubMed

[2] Nakayama A, Yamanaka K, Hayashi H, Ohkusu K. Moraxella lacunata infection associated with septicemia, endocarditis, and bilateral septic arthritis in a patient undergoing hemodialysis: a case report and review of literature. J Infect Chemother. 2014;20:61–4. 10.1016/j.jiac.2013.06.002.Search in Google Scholar PubMed

[3] Nadasdy T, Hebert LA. Infection-related glomerulonephritis: understanding mechanisms. Semin Nephrol. 2011;31:369–75. 10.1016/j.semnephrol.2011.06.008.Search in Google Scholar PubMed

[4] Nasr SH, Radhakrishnan J, D’Agati VD. Bacterial infection-related glomerulonephritis in adults. Kidney Int. 2013;83:792–803. 10.1038/ki.2012.407.Search in Google Scholar PubMed

[5] Woodbury A, Jorgensen J, Owens A, Henao-Martinez A. Moraxella lacunata septic arthritis in a patient with lupus nephritis. J Clin Microbiol. 2009;47:3787–8. 10.1128/JCM.01403-09.Search in Google Scholar PubMed PubMed Central

[6] Ray U, Kar S. Invasive infection due to Moraxella lacunata, an unusual pathogen. Southeast Asian J Trop Med Public Health. 2006;37:1183–6.Search in Google Scholar

[7] Juvin P, Boulot-Tolle M, Triller R, Juvin E. Moraxella lacunata infectious arthritis. J R Soc Med. 1991;84:629–30.10.1177/014107689108401027Search in Google Scholar

[8] Goldblum SE, Reed WP. Host defenses and immunologic alterations associated with chronic hemodialysis. Ann Intern Med. 1980;93:597–613. 10.7326/0003-4819-93-4-597.Search in Google Scholar PubMed

[9] Kato S, Chmielewski M, Honda H, Pecoits-Filho R, Matsuo S, Yuzawa Y, et al. Aspects of immune dysfunction in end-stage renal disease. Clin J Am Soc Nephrol. 2008;3:1526–33. 10.2215/CJN.00950208.Search in Google Scholar PubMed PubMed Central

[10] Schrier RW, Wang W. Acute renal failure and sepsis. N Engl J Med. 2004;351:159–69. 10.1056/NEJMra032401.Search in Google Scholar PubMed

[11] Moroni G, Pozzi C, Quaglini S, Segagni S, Banfi G, Baroli A, et al. Long-term prognosis of diffuse proliferative glomerulonephritis associated with infection in adults. Nephrol Dial Transpl. 2002;17:1204–11. 10.1093/ndt/17.7.1204.Search in Google Scholar PubMed

[12] Eison TM, Ault BH, Jones DP, Chesney RW, Wyatt RJ. Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis. Pediatr Nephrol. 2011;26:165–80. 10.1007/s00467-010-1554-6.Search in Google Scholar PubMed

[13] Nagano N, Sato J, Cordevant C, Nagano Y, Taguchi F, Inoue M. Presumed endocarditis caused by BRO beta-lactamase-producing Moraxella lacunata in an infant with Fallot’s tetrad. J Clin Microbiol. 2003;41:5310e2. 10.1128/jcm.41.11.5310-5312.2003.Search in Google Scholar

[14] Habib G, Lancellotti P, Antunes MJ, Casalta JP, Zotti FD, Dulgheru R, et al. 2015 ESC Guidelines for the management of infective endocarditis: the task force for the management of infective endocarditis of the European society of cardiology (ESC). Endorsed by: European association for cardio-thoracic surgery (EACTS), the European association of nuclear medicine (EANM). Eur Heart J. 2015;36:3075–128. 10.1093/eurheartj/ehv319.Search in Google Scholar PubMed

[15] Maayan H, Cohen-Poradosu R, Halperin E, Rudensky B, Schlesinger Y, Yinnon AM, et al. Infective endocarditis due to Moraxella lacunata: report of 4 patients and review of published cases of Moraxella endocarditis. Scand J Infect Dis. 2004;36:878–81. 10.1080/00365540410024925.Search in Google Scholar PubMed

Received: 2020-05-24
Revised: 2020-08-21
Accepted: 2020-09-03
Published Online: 2020-10-01

© 2020 Nami Sawada et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

Articles in the same Issue

  1. Research Article
  2. MicroRNA-451b participates in coronary heart disease by targeting VEGFA
  3. Case Report
  4. A combination therapy for Kawasaki disease with severe complications: a case report
  5. Vitamin E for prevention of biofilm-caused Healthcare-associated infections
  6. Research Article
  7. Differential diagnosis: retroperitoneal fibrosis and oncological diseases
  8. Optimization of the Convolutional Neural Networks for Automatic Detection of Skin Cancer
  9. NEAT1 promotes LPS-induced inflammatory injury in macrophages by regulating miR-17-5p/TLR4
  10. Plasma matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 as prognostic biomarkers in critically ill patients
  11. Effects of extracorporeal magnetic stimulation in fecal incontinence
  12. Case Report
  13. Mixed germ cell tumor of the endometrium: a case report and literature review
  14. Bowel perforation after ventriculoperitoneal-shunt placement: case report and review of the literature
  15. Research Article
  16. Prognostic value of lncRNA HOTAIR in colorectal cancer : a meta-analysis
  17. Case Report
  18. Treatment of insulinomas by laparoscopic radiofrequency ablation: case reports and literature review
  19. Research Article
  20. The characteristics and nomogram for primary lung papillary adenocarcinoma
  21. Undiagnosed pheochromocytoma presenting as a pancreatic tumor: A case report
  22. Bioinformatics Analysis of the Expression of ATP binding cassette subfamily C member 3 (ABCC3) in Human Glioma
  23. Diagnostic value of recombinant heparin-binding hemagglutinin adhesin protein in spinal tuberculosis
  24. Primary cutaneous DLBCL non-GCB type: challenges of a rare case
  25. LINC00152 knock-down suppresses esophageal cancer by EGFR signaling pathway
  26. Case Report
  27. Life-threatening anaemia in patient with hereditary haemorrhagic telangiectasia (Rendu-Osler-Weber syndrome)
  28. Research Article
  29. QTc interval predicts disturbed circadian blood pressure variation
  30. Shoulder ultrasound in the diagnosis of the suprascapular neuropathy in athletes
  31. The number of negative lymph nodes is positively associated with survival in esophageal squamous cell carcinoma patients in China
  32. Differentiation of pontine infarction by size
  33. RAF1 expression is correlated with HAF, a parameter of liver computed tomographic perfusion, and may predict the early therapeutic response to sorafenib in advanced hepatocellular carcinoma patients
  34. LncRNA ZEB1-AS1 regulates colorectal cancer cells by miR-205/YAP1 axis
  35. Tissue coagulation in laser hemorrhoidoplasty – an experimental study
  36. Classification of pathological types of lung cancer from CT images by deep residual neural networks with transfer learning strategy
  37. Enhanced Recovery after Surgery for Lung Cancer Patients
  38. Case Report
  39. Streptococcus pneumoniae-associated thrombotic microangiopathy in an immunosuppressed adult
  40. Research Article
  41. The characterization of Enterococcus genus: resistance mechanisms and inflammatory bowel disease
  42. Case Report
  43. Inflammatory fibroid polyp: an unusual cause of abdominal pain in the upper gastrointestinal tract A case report
  44. Research Article
  45. microRNA-204-5p participates in atherosclerosis via targeting MMP-9
  46. LncRNA LINC00152 promotes laryngeal cancer progression by sponging miR-613
  47. Can keratin scaffolds be used for creating three-dimensional cell cultures?
  48. miRNA-186 improves sepsis induced renal injury via PTEN/PI3K/AKT/P53 pathway
  49. Case Report
  50. Delayed bowel perforation after routine distal loopogram prior to ileostomy closure
  51. Research Article
  52. Diagnostic accuracy of MALDI-TOF mass spectrometry for the direct identification of clinical pathogens from urine
  53. The R219K polymorphism of the ATP binding cassette subfamily A member 1 gene and susceptibility to ischemic stroke in Chinese population
  54. miR-92 regulates the proliferation, migration, invasion and apoptosis of glioma cells by targeting neogenin
  55. Clinicopathological features of programmed cell death-ligand 1 expression in patients with oral squamous cell carcinoma
  56. NF2 inhibits proliferation and cancer stemness in breast cancer
  57. Body composition indices and cardiovascular risk in type 2 diabetes. CV biomarkers are not related to body composition
  58. S100A6 promotes proliferation and migration of HepG2 cells via increased ubiquitin-dependent degradation of p53
  59. Review Article
  60. Focus on localized laryngeal amyloidosis: management of five cases
  61. Research Article
  62. NEAT1 aggravates sepsis-induced acute kidney injury by sponging miR-22-3p
  63. Pericentric inversion in chromosome 1 and male infertility
  64. Increased atherogenic index in the general hearing loss population
  65. Prognostic role of SIRT6 in gastrointestinal cancers: a meta-analysis
  66. The complexity of molecular processes in osteoarthritis of the knee joint
  67. Interleukin-6 gene −572 G > C polymorphism and myocardial infarction risk
  68. Case Report
  69. Severe anaphylactic reaction to cisatracurium during anesthesia with cross-reactivity to atracurium
  70. Research Article
  71. Rehabilitation training improves nerve injuries by affecting Notch1 and SYN
  72. Case Report
  73. Myocardial amyloidosis following multiple myeloma in a 38-year-old female patient: A case report
  74. Research Article
  75. Identification of the hub genes RUNX2 and FN1 in gastric cancer
  76. miR-101-3p sensitizes non-small cell lung cancer cells to irradiation
  77. Distinct functions and prognostic values of RORs in gastric cancer
  78. Clinical impact of post-mortem genetic testing in cardiac death and cardiomyopathy
  79. Efficacy of pembrolizumab for advanced/metastatic melanoma: a meta-analysis
  80. Review Article
  81. The role of osteoprotegerin in the development, progression and management of abdominal aortic aneurysms
  82. Research Article
  83. Identification of key microRNAs of plasma extracellular vesicles and their diagnostic and prognostic significance in melanoma
  84. miR-30a-3p participates in the development of asthma by targeting CCR3
  85. microRNA-491-5p protects against atherosclerosis by targeting matrix metallopeptidase-9
  86. Bladder-embedded ectopic intrauterine device with calculus
  87. Case Report
  88. Mycobacterial identification on homogenised biopsy facilitates the early diagnosis and treatment of laryngeal tuberculosis
  89. Research Article
  90. The will of young minors in the terminal stage of sickness: A case report
  91. Extended perfusion protocol for MS lesion quantification
  92. Identification of four genes associated with cutaneous metastatic melanoma
  93. Case Report
  94. Thalidomide-induced serious RR interval prolongation (longest interval >5.0 s) in multiple myeloma patient with rectal cancer: A case report
  95. Research Article
  96. Voluntary exercise and cardiac remodeling in a myocardial infarction model
  97. Electromyography as an intraoperative test to assess the quality of nerve anastomosis – experimental study on rats
  98. Case Report
  99. CT findings of severe novel coronavirus disease (COVID-19): A case report of Heilongjiang Province, China
  100. Commentary
  101. Directed differentiation into insulin-producing cells using microRNA manipulation
  102. Research Article
  103. Culture-negative infective endocarditis (CNIE): impact on postoperative mortality
  104. Extracorporeal shock wave therapy for the treatment of chronic pelvic pain syndrome
  105. Plasma microRNAs in human left ventricular reverse remodelling
  106. Bevacizumab for non-small cell lung cancer patients with brain metastasis: A meta-analysis
  107. Risk factors for cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage
  108. Problems and solutions of personal protective equipment doffing in COVID-19
  109. Evaluation of COVID-19 based on ACE2 expression in normal and cancer patients
  110. Review Article
  111. Gastroenterological complications in kidney transplant patients
  112. Research Article
  113. CXCL13 concentration in latent syphilis patients with treatment failure
  114. A novel age-biomarker-clinical history prognostic index for heart failure with reduced left ventricular ejection fraction
  115. Case Report
  116. Clinicopathological analysis of composite lymphoma: A two-case report and literature review
  117. Trastuzumab-induced thrombocytopenia after eight cycles of trastuzumab treatment
  118. Research Article
  119. Inhibition of vitamin D analog eldecalcitol on hepatoma in vitro and in vivo
  120. CCTs as new biomarkers for the prognosis of head and neck squamous cancer
  121. Effect of glucagon-like peptide-1 receptor agonists on adipokine level of nonalcoholic fatty liver disease in rats fed high-fat diet
  122. 72 hour Holter monitoring, 7 day Holter monitoring, and 30 day intermittent patient-activated heart rhythm recording in detecting arrhythmias in cryptogenic stroke patients free from arrhythmia in a screening 24 h Holter
  123. FOXK2 downregulation suppresses EMT in hepatocellular carcinoma
  124. Case Report
  125. Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
  126. Research Article
  127. Clinical prediction for outcomes of patients with acute-on-chronic liver failure associated with HBV infection: A new model establishment
  128. Case Report
  129. Combination of chest CT and clinical features for diagnosis of 2019 novel coronavirus pneumonia
  130. Research Article
  131. Clinical significance and potential mechanisms of miR-223-3p and miR-204-5p in squamous cell carcinoma of head and neck: a study based on TCGA and GEO
  132. Review Article
  133. Hemoperitoneum caused by spontaneous rupture of hepatocellular carcinoma in noncirrhotic liver. A case report and systematic review
  134. Research Article
  135. Voltage-dependent anion channels mediated apoptosis in refractory epilepsy
  136. Prognostic factors in stage I gastric cancer: A retrospective analysis
  137. Circulating irisin is linked to bone mineral density in geriatric Chinese men
  138. Case Report
  139. A family study of congenital dysfibrinogenemia caused by a novel mutation in the FGA gene: A case report
  140. Research Article
  141. CBCT for estimation of the cemento-enamel junction and crestal bone of anterior teeth
  142. Case Report
  143. Successful de-escalation antibiotic therapy using cephamycins for sepsis caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae bacteremia: A sequential 25-case series
  144. Research Article
  145. Influence factors of extra-articular manifestations in rheumatoid arthritis
  146. Assessment of knowledge of use of electronic cigarette and its harmful effects among young adults
  147. Predictive factors of progression to severe COVID-19
  148. Procedural sedation and analgesia for percutaneous trans-hepatic biliary drainage: Randomized clinical trial for comparison of two different concepts
  149. Acute chemoradiotherapy toxicity in cervical cancer patients
  150. IGF-1 regulates the growth of fibroblasts and extracellular matrix deposition in pelvic organ prolapse
  151. NANOG regulates the proliferation of PCSCs via the TGF-β1/SMAD pathway
  152. An immune-relevant signature of nine genes as a prognostic biomarker in patients with gastric carcinoma
  153. Computer-aided diagnosis of skin cancer based on soft computing techniques
  154. MiR-1225-5p acts as tumor suppressor in glioblastoma via targeting FNDC3B
  155. miR-300/FA2H affects gastric cancer cell proliferation and apoptosis
  156. Hybrid treatment of fibroadipose vascular anomaly: A case report
  157. Surgical treatment for common hepatic aneurysm. Original one-step technique
  158. Neuropsychiatric symptoms, quality of life and caregivers’ burden in dementia
  159. Predictor of postoperative dyspnea for Pierre Robin Sequence infants
  160. Long non-coding RNA FOXD2-AS1 promotes cell proliferation, metastasis and EMT in glioma by sponging miR-506-5p
  161. Analysis of expression and prognosis of KLK7 in ovarian cancer
  162. Circular RNA circ_SETD2 represses breast cancer progression via modulating the miR-155-5p/SCUBE2 axis
  163. Glial cell induced neural differentiation of bone marrow stromal cells
  164. Case Report
  165. Moraxella lacunata infection accompanied by acute glomerulonephritis
  166. Research Article
  167. Diagnosis of complication in lung transplantation by TBLB + ROSE + mNGS
  168. Case Report
  169. Endometrial cancer in a renal transplant recipient: A case report
  170. Research Article
  171. Downregulation of lncRNA FGF12-AS2 suppresses the tumorigenesis of NSCLC via sponging miR-188-3p
  172. Case Report
  173. Splenic abscess caused by Streptococcus anginosus bacteremia secondary to urinary tract infection: a case report and literature review
  174. Research Article
  175. Advances in the role of miRNAs in the occurrence and development of osteosarcoma
  176. Rheumatoid arthritis increases the risk of pleural empyema
  177. Effect of miRNA-200b on the proliferation and apoptosis of cervical cancer cells by targeting RhoA
  178. LncRNA NEAT1 promotes gastric cancer progression via miR-1294/AKT1 axis
  179. Key pathways in prostate cancer with SPOP mutation identified by bioinformatic analysis
  180. Comparison of low-molecular-weight heparins in thromboprophylaxis of major orthopaedic surgery – randomized, prospective pilot study
  181. Case Report
  182. A case of SLE with COVID-19 and multiple infections
  183. Research Article
  184. Circular RNA hsa_circ_0007121 regulates proliferation, migration, invasion, and epithelial–mesenchymal transition of trophoblast cells by miR-182-5p/PGF axis in preeclampsia
  185. SRPX2 boosts pancreatic cancer chemoresistance by activating PI3K/AKT axis
  186. Case Report
  187. A case report of cervical pregnancy after in vitro fertilization complicated by tuberculosis and a literature review
  188. Review Article
  189. Serrated lesions of the colon and rectum: Emergent epidemiological data and molecular pathways
  190. Research Article
  191. Biological properties and therapeutic effects of plant-derived nanovesicles
  192. Case Report
  193. Clinical characterization of chromosome 5q21.1–21.3 microduplication: A case report
  194. Research Article
  195. Serum calcium levels correlates with coronary artery disease outcomes
  196. Rapunzel syndrome with cholangitis and pancreatitis – A rare case report
  197. Review Article
  198. A review of current progress in triple-negative breast cancer therapy
  199. Case Report
  200. Peritoneal-cutaneous fistula successfully treated at home: A case report and literature review
  201. Research Article
  202. Trim24 prompts tumor progression via inducing EMT in renal cell carcinoma
  203. Degradation of connexin 50 protein causes waterclefts in human lens
  204. GABRD promotes progression and predicts poor prognosis in colorectal cancer
  205. The lncRNA UBE2R2-AS1 suppresses cervical cancer cell growth in vitro
  206. LncRNA FOXD3-AS1/miR-135a-5p function in nasopharyngeal carcinoma cells
  207. MicroRNA-182-5p relieves murine allergic rhinitis via TLR4/NF-κB pathway
https://doi.org/10.1515/med-2020-0234
Keywords for this article
Moraxella lacunata; children; complement activity; hemodialysis; sepsis
Creative Commons
BY 4.0

Articles in the same Issue

  1. Research Article
  2. MicroRNA-451b participates in coronary heart disease by targeting VEGFA
  3. Case Report
  4. A combination therapy for Kawasaki disease with severe complications: a case report
  5. Vitamin E for prevention of biofilm-caused Healthcare-associated infections
  6. Research Article
  7. Differential diagnosis: retroperitoneal fibrosis and oncological diseases
  8. Optimization of the Convolutional Neural Networks for Automatic Detection of Skin Cancer
  9. NEAT1 promotes LPS-induced inflammatory injury in macrophages by regulating miR-17-5p/TLR4
  10. Plasma matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 as prognostic biomarkers in critically ill patients
  11. Effects of extracorporeal magnetic stimulation in fecal incontinence
  12. Case Report
  13. Mixed germ cell tumor of the endometrium: a case report and literature review
  14. Bowel perforation after ventriculoperitoneal-shunt placement: case report and review of the literature
  15. Research Article
  16. Prognostic value of lncRNA HOTAIR in colorectal cancer : a meta-analysis
  17. Case Report
  18. Treatment of insulinomas by laparoscopic radiofrequency ablation: case reports and literature review
  19. Research Article
  20. The characteristics and nomogram for primary lung papillary adenocarcinoma
  21. Undiagnosed pheochromocytoma presenting as a pancreatic tumor: A case report
  22. Bioinformatics Analysis of the Expression of ATP binding cassette subfamily C member 3 (ABCC3) in Human Glioma
  23. Diagnostic value of recombinant heparin-binding hemagglutinin adhesin protein in spinal tuberculosis
  24. Primary cutaneous DLBCL non-GCB type: challenges of a rare case
  25. LINC00152 knock-down suppresses esophageal cancer by EGFR signaling pathway
  26. Case Report
  27. Life-threatening anaemia in patient with hereditary haemorrhagic telangiectasia (Rendu-Osler-Weber syndrome)
  28. Research Article
  29. QTc interval predicts disturbed circadian blood pressure variation
  30. Shoulder ultrasound in the diagnosis of the suprascapular neuropathy in athletes
  31. The number of negative lymph nodes is positively associated with survival in esophageal squamous cell carcinoma patients in China
  32. Differentiation of pontine infarction by size
  33. RAF1 expression is correlated with HAF, a parameter of liver computed tomographic perfusion, and may predict the early therapeutic response to sorafenib in advanced hepatocellular carcinoma patients
  34. LncRNA ZEB1-AS1 regulates colorectal cancer cells by miR-205/YAP1 axis
  35. Tissue coagulation in laser hemorrhoidoplasty – an experimental study
  36. Classification of pathological types of lung cancer from CT images by deep residual neural networks with transfer learning strategy
  37. Enhanced Recovery after Surgery for Lung Cancer Patients
  38. Case Report
  39. Streptococcus pneumoniae-associated thrombotic microangiopathy in an immunosuppressed adult
  40. Research Article
  41. The characterization of Enterococcus genus: resistance mechanisms and inflammatory bowel disease
  42. Case Report
  43. Inflammatory fibroid polyp: an unusual cause of abdominal pain in the upper gastrointestinal tract A case report
  44. Research Article
  45. microRNA-204-5p participates in atherosclerosis via targeting MMP-9
  46. LncRNA LINC00152 promotes laryngeal cancer progression by sponging miR-613
  47. Can keratin scaffolds be used for creating three-dimensional cell cultures?
  48. miRNA-186 improves sepsis induced renal injury via PTEN/PI3K/AKT/P53 pathway
  49. Case Report
  50. Delayed bowel perforation after routine distal loopogram prior to ileostomy closure
  51. Research Article
  52. Diagnostic accuracy of MALDI-TOF mass spectrometry for the direct identification of clinical pathogens from urine
  53. The R219K polymorphism of the ATP binding cassette subfamily A member 1 gene and susceptibility to ischemic stroke in Chinese population
  54. miR-92 regulates the proliferation, migration, invasion and apoptosis of glioma cells by targeting neogenin
  55. Clinicopathological features of programmed cell death-ligand 1 expression in patients with oral squamous cell carcinoma
  56. NF2 inhibits proliferation and cancer stemness in breast cancer
  57. Body composition indices and cardiovascular risk in type 2 diabetes. CV biomarkers are not related to body composition
  58. S100A6 promotes proliferation and migration of HepG2 cells via increased ubiquitin-dependent degradation of p53
  59. Review Article
  60. Focus on localized laryngeal amyloidosis: management of five cases
  61. Research Article
  62. NEAT1 aggravates sepsis-induced acute kidney injury by sponging miR-22-3p
  63. Pericentric inversion in chromosome 1 and male infertility
  64. Increased atherogenic index in the general hearing loss population
  65. Prognostic role of SIRT6 in gastrointestinal cancers: a meta-analysis
  66. The complexity of molecular processes in osteoarthritis of the knee joint
  67. Interleukin-6 gene −572 G > C polymorphism and myocardial infarction risk
  68. Case Report
  69. Severe anaphylactic reaction to cisatracurium during anesthesia with cross-reactivity to atracurium
  70. Research Article
  71. Rehabilitation training improves nerve injuries by affecting Notch1 and SYN
  72. Case Report
  73. Myocardial amyloidosis following multiple myeloma in a 38-year-old female patient: A case report
  74. Research Article
  75. Identification of the hub genes RUNX2 and FN1 in gastric cancer
  76. miR-101-3p sensitizes non-small cell lung cancer cells to irradiation
  77. Distinct functions and prognostic values of RORs in gastric cancer
  78. Clinical impact of post-mortem genetic testing in cardiac death and cardiomyopathy
  79. Efficacy of pembrolizumab for advanced/metastatic melanoma: a meta-analysis
  80. Review Article
  81. The role of osteoprotegerin in the development, progression and management of abdominal aortic aneurysms
  82. Research Article
  83. Identification of key microRNAs of plasma extracellular vesicles and their diagnostic and prognostic significance in melanoma
  84. miR-30a-3p participates in the development of asthma by targeting CCR3
  85. microRNA-491-5p protects against atherosclerosis by targeting matrix metallopeptidase-9
  86. Bladder-embedded ectopic intrauterine device with calculus
  87. Case Report
  88. Mycobacterial identification on homogenised biopsy facilitates the early diagnosis and treatment of laryngeal tuberculosis
  89. Research Article
  90. The will of young minors in the terminal stage of sickness: A case report
  91. Extended perfusion protocol for MS lesion quantification
  92. Identification of four genes associated with cutaneous metastatic melanoma
  93. Case Report
  94. Thalidomide-induced serious RR interval prolongation (longest interval >5.0 s) in multiple myeloma patient with rectal cancer: A case report
  95. Research Article
  96. Voluntary exercise and cardiac remodeling in a myocardial infarction model
  97. Electromyography as an intraoperative test to assess the quality of nerve anastomosis – experimental study on rats
  98. Case Report
  99. CT findings of severe novel coronavirus disease (COVID-19): A case report of Heilongjiang Province, China
  100. Commentary
  101. Directed differentiation into insulin-producing cells using microRNA manipulation
  102. Research Article
  103. Culture-negative infective endocarditis (CNIE): impact on postoperative mortality
  104. Extracorporeal shock wave therapy for the treatment of chronic pelvic pain syndrome
  105. Plasma microRNAs in human left ventricular reverse remodelling
  106. Bevacizumab for non-small cell lung cancer patients with brain metastasis: A meta-analysis
  107. Risk factors for cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage
  108. Problems and solutions of personal protective equipment doffing in COVID-19
  109. Evaluation of COVID-19 based on ACE2 expression in normal and cancer patients
  110. Review Article
  111. Gastroenterological complications in kidney transplant patients
  112. Research Article
  113. CXCL13 concentration in latent syphilis patients with treatment failure
  114. A novel age-biomarker-clinical history prognostic index for heart failure with reduced left ventricular ejection fraction
  115. Case Report
  116. Clinicopathological analysis of composite lymphoma: A two-case report and literature review
  117. Trastuzumab-induced thrombocytopenia after eight cycles of trastuzumab treatment
  118. Research Article
  119. Inhibition of vitamin D analog eldecalcitol on hepatoma in vitro and in vivo
  120. CCTs as new biomarkers for the prognosis of head and neck squamous cancer
  121. Effect of glucagon-like peptide-1 receptor agonists on adipokine level of nonalcoholic fatty liver disease in rats fed high-fat diet
  122. 72 hour Holter monitoring, 7 day Holter monitoring, and 30 day intermittent patient-activated heart rhythm recording in detecting arrhythmias in cryptogenic stroke patients free from arrhythmia in a screening 24 h Holter
  123. FOXK2 downregulation suppresses EMT in hepatocellular carcinoma
  124. Case Report
  125. Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery
  126. Research Article
  127. Clinical prediction for outcomes of patients with acute-on-chronic liver failure associated with HBV infection: A new model establishment
  128. Case Report
  129. Combination of chest CT and clinical features for diagnosis of 2019 novel coronavirus pneumonia
  130. Research Article
  131. Clinical significance and potential mechanisms of miR-223-3p and miR-204-5p in squamous cell carcinoma of head and neck: a study based on TCGA and GEO
  132. Review Article
  133. Hemoperitoneum caused by spontaneous rupture of hepatocellular carcinoma in noncirrhotic liver. A case report and systematic review
  134. Research Article
  135. Voltage-dependent anion channels mediated apoptosis in refractory epilepsy
  136. Prognostic factors in stage I gastric cancer: A retrospective analysis
  137. Circulating irisin is linked to bone mineral density in geriatric Chinese men
  138. Case Report
  139. A family study of congenital dysfibrinogenemia caused by a novel mutation in the FGA gene: A case report
  140. Research Article
  141. CBCT for estimation of the cemento-enamel junction and crestal bone of anterior teeth
  142. Case Report
  143. Successful de-escalation antibiotic therapy using cephamycins for sepsis caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae bacteremia: A sequential 25-case series
  144. Research Article
  145. Influence factors of extra-articular manifestations in rheumatoid arthritis
  146. Assessment of knowledge of use of electronic cigarette and its harmful effects among young adults
  147. Predictive factors of progression to severe COVID-19
  148. Procedural sedation and analgesia for percutaneous trans-hepatic biliary drainage: Randomized clinical trial for comparison of two different concepts
  149. Acute chemoradiotherapy toxicity in cervical cancer patients
  150. IGF-1 regulates the growth of fibroblasts and extracellular matrix deposition in pelvic organ prolapse
  151. NANOG regulates the proliferation of PCSCs via the TGF-β1/SMAD pathway
  152. An immune-relevant signature of nine genes as a prognostic biomarker in patients with gastric carcinoma
  153. Computer-aided diagnosis of skin cancer based on soft computing techniques
  154. MiR-1225-5p acts as tumor suppressor in glioblastoma via targeting FNDC3B
  155. miR-300/FA2H affects gastric cancer cell proliferation and apoptosis
  156. Hybrid treatment of fibroadipose vascular anomaly: A case report
  157. Surgical treatment for common hepatic aneurysm. Original one-step technique
  158. Neuropsychiatric symptoms, quality of life and caregivers’ burden in dementia
  159. Predictor of postoperative dyspnea for Pierre Robin Sequence infants
  160. Long non-coding RNA FOXD2-AS1 promotes cell proliferation, metastasis and EMT in glioma by sponging miR-506-5p
  161. Analysis of expression and prognosis of KLK7 in ovarian cancer
  162. Circular RNA circ_SETD2 represses breast cancer progression via modulating the miR-155-5p/SCUBE2 axis
  163. Glial cell induced neural differentiation of bone marrow stromal cells
  164. Case Report
  165. Moraxella lacunata infection accompanied by acute glomerulonephritis
  166. Research Article
  167. Diagnosis of complication in lung transplantation by TBLB + ROSE + mNGS
  168. Case Report
  169. Endometrial cancer in a renal transplant recipient: A case report
  170. Research Article
  171. Downregulation of lncRNA FGF12-AS2 suppresses the tumorigenesis of NSCLC via sponging miR-188-3p
  172. Case Report
  173. Splenic abscess caused by Streptococcus anginosus bacteremia secondary to urinary tract infection: a case report and literature review
  174. Research Article
  175. Advances in the role of miRNAs in the occurrence and development of osteosarcoma
  176. Rheumatoid arthritis increases the risk of pleural empyema
  177. Effect of miRNA-200b on the proliferation and apoptosis of cervical cancer cells by targeting RhoA
  178. LncRNA NEAT1 promotes gastric cancer progression via miR-1294/AKT1 axis
  179. Key pathways in prostate cancer with SPOP mutation identified by bioinformatic analysis
  180. Comparison of low-molecular-weight heparins in thromboprophylaxis of major orthopaedic surgery – randomized, prospective pilot study
  181. Case Report
  182. A case of SLE with COVID-19 and multiple infections
  183. Research Article
  184. Circular RNA hsa_circ_0007121 regulates proliferation, migration, invasion, and epithelial–mesenchymal transition of trophoblast cells by miR-182-5p/PGF axis in preeclampsia
  185. SRPX2 boosts pancreatic cancer chemoresistance by activating PI3K/AKT axis
  186. Case Report
  187. A case report of cervical pregnancy after in vitro fertilization complicated by tuberculosis and a literature review
  188. Review Article
  189. Serrated lesions of the colon and rectum: Emergent epidemiological data and molecular pathways
  190. Research Article
  191. Biological properties and therapeutic effects of plant-derived nanovesicles
  192. Case Report
  193. Clinical characterization of chromosome 5q21.1–21.3 microduplication: A case report
  194. Research Article
  195. Serum calcium levels correlates with coronary artery disease outcomes
  196. Rapunzel syndrome with cholangitis and pancreatitis – A rare case report
  197. Review Article
  198. A review of current progress in triple-negative breast cancer therapy
  199. Case Report
  200. Peritoneal-cutaneous fistula successfully treated at home: A case report and literature review
  201. Research Article
  202. Trim24 prompts tumor progression via inducing EMT in renal cell carcinoma
  203. Degradation of connexin 50 protein causes waterclefts in human lens
  204. GABRD promotes progression and predicts poor prognosis in colorectal cancer
  205. The lncRNA UBE2R2-AS1 suppresses cervical cancer cell growth in vitro
  206. LncRNA FOXD3-AS1/miR-135a-5p function in nasopharyngeal carcinoma cells
  207. MicroRNA-182-5p relieves murine allergic rhinitis via TLR4/NF-κB pathway
Sign up now to receive a 20% welcome discount
Institutional Access
How does access work?
Have an idea on how to improve our website?
Please write us.
© 2025 De Gruyter Brill
Downloaded on 4.10.2025 from https://www.degruyterbrill.com/document/doi/10.1515/med-2020-0234/html?lang=en&srsltid=AfmBOoqrkteTV64519e0_lVwTLn-_35qGOz7SGKl9Jl44EBIhJpnjlyy
Scroll to top button