Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review
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Danish Javed
und
Ashish Kumar Dixit
Abstract
Objectives
The aim of this review is to summarise and appraise the findings of various studies on Trikatu.
Content
COVID-19 or SARS-CoV-2 disease a pandemic principally contaminating the respiratory tract and bringing about Severe Acute Respiratory Syndrome is liable for significant mortality around the world. Far-fetched, there is no exact treatment accessible till today. Consequently, it is critical to discover the alternative methodology which can decrease the weight of illness. Trikatu powder recommended by authorities for the management of mild cases of COVID-19 is a conventional ayurvedic formulation containing three spices; Zingiber officinale, Piper nigrum, and Piper longum. A comprehensive search of the articles published since inception to 01/08/2020 on Trikatu was carried out. Major electronic medical databases such as Pub Med/MEDLINE and Cochrane Database of Systematic Reviews were used for the literature search.
Summary
A total of 21 records were identified by electronic searches between since inception to 01/08/2020 of which 13 records were included for review. The reviewed articles highlight Trikatu as a safe, anti-inflammatory, and immune-modulatory property by suppression of the production of pro-inflammatory cytokines TNF-a, IL-1b, IL-6, IL-17, alteration in levels of circulating immune complexes, anti-dyslipidaemia agent by reduced triglycerides and LDL cholesterol and increased HDL cholesterol, enhancing bio-availability of co-drug by reducing the elimination half-life (t1/2β) and zero time intercept of the elimination phase.
Outlook
The findings of this review seem to show Trikatu as a potential anti-inflammatory, anti-dyslipidaemia, and immune-modulatory ayurvedic formulation can be used for combating flu like illnesses and also in the management of COVID-19 as an adjuvant. However, rigorous double blind randomized controlled trials with larger sample size are warranted for better validation in such clinical conditions.
Highlights
COVID-19 has affected the lives of millions worldwide and unfortunately no precise treatment available till today.
Trikatu an ayurvedic formulation suggested by various authorities in India.
Trikatu found to be a potential anti-inflammatory; anti-dyslipidaemia and immune-modulatory drug can be used for combating flu like illnesses.
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Research funding: None declared.
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Author contributions: DJ and AKD both the authors were involved in concept, design, literature search, data compilation, interpretation and preparation of the manuscript. Both the authors reviewed and approved the final article.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Not applicable.
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Ethical approval: Not applicable.
References
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
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- Reviews
- Swarna Prashana – faith in the embrace of research
- A review on the concept of aging in Ayurveda literature
- Ethno-pharmacology of Asaroon (Asarum europaeum L.) with special reference to Unani System of Medicine
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- The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements
- Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
- Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis
- The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism
- Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses
- Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
- Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats
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Artikel in diesem Heft
- Frontmatter
- Reviews
- Swarna Prashana – faith in the embrace of research
- A review on the concept of aging in Ayurveda literature
- Ethno-pharmacology of Asaroon (Asarum europaeum L.) with special reference to Unani System of Medicine
- Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review
- The anti-cancer properties of neem (Azadirachta indica) through its antioxidant activity in the liver: its pharmaceutics and toxic dosage forms. A literature review
- The role of acupuncture for myofascial pain syndrome (MPS) in interventional pain management
- Research Articles
- Identification of phenolic compounds in the buds of Algerian Pistacia atlantica desf. Subsp. atlantica by antioxidant activity guided fractionation
- Optimization of water-based ultrasonic-microwave assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
- Proximate analysis, HPTLC finger print analysis and multi spectrometric analysis of Strychnos nux-vomica nuts
- Amelioration of sodium fluoride induced oxidative stress by Cynometra travancorica Bedd in mice
- The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements
- Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
- Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis
- The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism
- Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses
- Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
- Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats
- The effect of Cinnamomum cassia extract on oxidative stress in the liver and kidney of STZ-induced diabetic rats
- Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats
- Ameliorating activity of polyphenolic-rich extracts of Basella rubra L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats
- Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice
- The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance
- Anti-obesity effects of the n-butanol fraction of the methanolic leaf extract of Artemisia campestris from Tunisian pharmacopeia in male Wistar rats
- Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats
- Preventing SARS-CoV-2 transmission in the emergency department by implementing a separate pathway for patients with respiratory conditions
- Clinical significance of serum gonadotropin and androgen levels among Egyptian overweight/obese pubertal girls
- Preference between serum homocysteine and urinary periostin as early predictive biomarkers of renal dysfunction among uncontrolled diabetics
- Mizaj assessment in multiple sclerosis patients based on Persian Medicine
- Immediate effects of the practise of Sheethali pranayama on heart rate and blood pressure parameters in healthy volunteers
- Effects of 12 sessions of steam bath intervention on spirometry parameters among healthy adult volunteers
- The effects of psychological counseling and acupressure based on couple therapy procedure for alleviation of vomiting and nausea in pregnant women in Iran country
- “The immediate effect of neutral spinal compress on heart rate variability in hypertensive individuals”
- Effect of whole-body vibration after a resistance exercise bout on heart rate variability in hypertensive population
- Wet-cupping on calf muscles in polycystic ovary syndrome: a quasi-experimental study
- Auricular field nerve stimulation using the NSS-2 BRIDGE® device as an alternative to opioids following kidney donor surgery
- Evaluation of general body temperament and uterine dystemperament in amenorrhoea: a cross-sectional analytical study
- Short Communication
- Isolation, characterization, and antimicrobial activity of communic acid from Juniperus phoenicea
- Letter to the Editor
- Can silymarin ameliorate β-thalassemia major-induced osteopenia/osteoporosis?
- Case Reports
- Management of psoriasis with Ayurveda Panchakarma and Manibhadragula as Shodhana Rasayana – a case report
- Psychogenic pseudo-myasthenic ptosis – management with ayurvedic medicines and Smriti meditation
- Education Forum
- Tongue stretching: technique and clinical proposal
- Simulation-based ventilatory training for the caregivers at primary and rural health care workers in Central India for dealing with COVID-19 pandemic: recommendations
