Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
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Niloofar Honari
Abstract
Objectives
Acute lung injury (ALI) is a life-threatening pulmonary dysfunction associated with severe inflammation. There are still no effective pharmacological therapies for the treatment of ALI. In this concern, several anti-inflammatory agents could be used as add-on therapy to inhibit inflammation. Achillea wilhelmsii (AW) C. Koch is a well-known medicinal plant in the Iranian ethnomedical practices with anti-inflammatory activity. This study was aimed to evaluate the efficacy of ethanolic extract of AW on lipopolysaccharide (LPS)-induced ALI in mice.
Methods
The ALI model was established via the intra-tracheal (i.t.) administration of LPS (2 mg/kg) to male BALB/c mice. The ALI mice were divided into four groups (n=8 each) which intra-peritoneally (i.p.) treated with repeated doses of saline (model), dexamethasone (2 mg/kg), and AW (150–300 mg/kg) 1, 11 and 23 h post LPS administration. Twenty-four hours after the LPS challenge, bronchoalveolar lavage fluid (BALF) and lung tissue were evaluated for inflammatory cell influx, level of tumor necrosis factor-α (TNF-α) and histopathological changes.
Results
The AW (150–300 mg/kg) treated mice showed lower inflammatory cells infiltration in BALF and TNF-α level when compared to the model group. In addition, LPS induced several pathological alterations such as edema, alveolar hemorrhage and inflammatory cell infiltration into the interstitium and alveolar spaces. Treatment with AW significantly reduced LPS-induced pathological injury.
Conclusions
Taken together, the data here indicated that AW may be considered as a promising add-on therapy for ALI.
Funding source: Birjand University of Medical Sciences
Award Identifier / Grant number: 5150
Acknowledgments
We appreciate Ms. Vazifeshenas and Mr. Kabiri (Laboratory technologists, BUMS) for their technical assistance. The authors would like to thank Dr. Zardast for helping us in cell differentiation.
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Research funding: Birjand University of Medical Sciences (Grant number: 5150).
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The authors have no financial or nonfinancial conflicts of interest to declare.
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Informed consent: Not applicable.
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Ethical approval: All procedures involving animals were in accordance with the national guides in care and use of Laboratory Animals in Scientific Affairs provided by the Iranian Ministry of Health and Medical Education (2019). The guideline is following 1964 Helsinki declaration and its later amendments or comparable ethical standards. Moreover, the animal experiments were approved by the Birjand University of Medical Sciences Ethics Committee (permit code: IR.BUMS.REC.1398.260).
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Reviews
- Swarna Prashana – faith in the embrace of research
- A review on the concept of aging in Ayurveda literature
- Ethno-pharmacology of Asaroon (Asarum europaeum L.) with special reference to Unani System of Medicine
- Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review
- The anti-cancer properties of neem (Azadirachta indica) through its antioxidant activity in the liver: its pharmaceutics and toxic dosage forms. A literature review
- The role of acupuncture for myofascial pain syndrome (MPS) in interventional pain management
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- Optimization of water-based ultrasonic-microwave assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
- Proximate analysis, HPTLC finger print analysis and multi spectrometric analysis of Strychnos nux-vomica nuts
- Amelioration of sodium fluoride induced oxidative stress by Cynometra travancorica Bedd in mice
- The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements
- Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
- Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis
- The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism
- Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses
- Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
- Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats
- The effect of Cinnamomum cassia extract on oxidative stress in the liver and kidney of STZ-induced diabetic rats
- Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats
- Ameliorating activity of polyphenolic-rich extracts of Basella rubra L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats
- Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice
- The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance
- Anti-obesity effects of the n-butanol fraction of the methanolic leaf extract of Artemisia campestris from Tunisian pharmacopeia in male Wistar rats
- Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats
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- Effects of 12 sessions of steam bath intervention on spirometry parameters among healthy adult volunteers
- The effects of psychological counseling and acupressure based on couple therapy procedure for alleviation of vomiting and nausea in pregnant women in Iran country
- “The immediate effect of neutral spinal compress on heart rate variability in hypertensive individuals”
- Effect of whole-body vibration after a resistance exercise bout on heart rate variability in hypertensive population
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- Letter to the Editor
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Artikel in diesem Heft
- Frontmatter
- Reviews
- Swarna Prashana – faith in the embrace of research
- A review on the concept of aging in Ayurveda literature
- Ethno-pharmacology of Asaroon (Asarum europaeum L.) with special reference to Unani System of Medicine
- Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review
- The anti-cancer properties of neem (Azadirachta indica) through its antioxidant activity in the liver: its pharmaceutics and toxic dosage forms. A literature review
- The role of acupuncture for myofascial pain syndrome (MPS) in interventional pain management
- Research Articles
- Identification of phenolic compounds in the buds of Algerian Pistacia atlantica desf. Subsp. atlantica by antioxidant activity guided fractionation
- Optimization of water-based ultrasonic-microwave assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
- Proximate analysis, HPTLC finger print analysis and multi spectrometric analysis of Strychnos nux-vomica nuts
- Amelioration of sodium fluoride induced oxidative stress by Cynometra travancorica Bedd in mice
- The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements
- Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
- Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis
- The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism
- Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses
- Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
- Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats
- The effect of Cinnamomum cassia extract on oxidative stress in the liver and kidney of STZ-induced diabetic rats
- Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats
- Ameliorating activity of polyphenolic-rich extracts of Basella rubra L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats
- Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice
- The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance
- Anti-obesity effects of the n-butanol fraction of the methanolic leaf extract of Artemisia campestris from Tunisian pharmacopeia in male Wistar rats
- Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats
- Preventing SARS-CoV-2 transmission in the emergency department by implementing a separate pathway for patients with respiratory conditions
- Clinical significance of serum gonadotropin and androgen levels among Egyptian overweight/obese pubertal girls
- Preference between serum homocysteine and urinary periostin as early predictive biomarkers of renal dysfunction among uncontrolled diabetics
- Mizaj assessment in multiple sclerosis patients based on Persian Medicine
- Immediate effects of the practise of Sheethali pranayama on heart rate and blood pressure parameters in healthy volunteers
- Effects of 12 sessions of steam bath intervention on spirometry parameters among healthy adult volunteers
- The effects of psychological counseling and acupressure based on couple therapy procedure for alleviation of vomiting and nausea in pregnant women in Iran country
- “The immediate effect of neutral spinal compress on heart rate variability in hypertensive individuals”
- Effect of whole-body vibration after a resistance exercise bout on heart rate variability in hypertensive population
- Wet-cupping on calf muscles in polycystic ovary syndrome: a quasi-experimental study
- Auricular field nerve stimulation using the NSS-2 BRIDGE® device as an alternative to opioids following kidney donor surgery
- Evaluation of general body temperament and uterine dystemperament in amenorrhoea: a cross-sectional analytical study
- Short Communication
- Isolation, characterization, and antimicrobial activity of communic acid from Juniperus phoenicea
- Letter to the Editor
- Can silymarin ameliorate β-thalassemia major-induced osteopenia/osteoporosis?
- Case Reports
- Management of psoriasis with Ayurveda Panchakarma and Manibhadragula as Shodhana Rasayana – a case report
- Psychogenic pseudo-myasthenic ptosis – management with ayurvedic medicines and Smriti meditation
- Education Forum
- Tongue stretching: technique and clinical proposal
- Simulation-based ventilatory training for the caregivers at primary and rural health care workers in Central India for dealing with COVID-19 pandemic: recommendations
