The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements
-
Nazanin Majidi
and
Majid Karandish
Abstract
Objectives
Diabetes is a chronic disease caused by high blood sugar greatly affected by diet. The chemical medicines applied to treat diabetes usually have side effects. This study aimed to investigate the effect of saffron petals, damask rose petals, and saffron-damask rose petal herbal teas on weight loss, fasting blood sugar, lipid profile, and the inflammatory factors of diabetic rats.
Methods
In this study, 40 male Sprague Dawley rats with an average age of four weeks received a high-calorie, high-fat, high-sugar diet for nine weeks. The rats were then randomly assigned to five groups, including normal, control, saffron petal, damask rose petal, and saffron plus damask rose petal groups. For nine weeks, 3 mL of the herbal tea was administered to the intervention groups daily through oral gavage. The levels of FBS, lipid profile, Insulin-like growth factor 1 (IGF-1), the high-sensitivity C-reactive protein (hs-CRP), hemoglobin A1c (HbA1C), and glucose tolerance test (GTT) were measured following the intervention.
Results
Saffron petals reduced weight gain, Triglyceride (TG), and HbA1c and increased hs-CRP and IGF-1 (all p < 0.05). The damask rose petal reduced weight gain, FBS, hs-CRP, and HbA1c and increased the IGF-1 (all p < 0.05). Saffron plus damask-rose petals reduced the weight gain, TG, hs-CRP and HbA1c, and increase IGF-1 factor (all p < 0.05) compared to the control group. No significant effect was found on visceral fat, LDL-C, and HDL-C. Compared with the normal group, saffron petals and damask rose petals increased the FBS, HDL, and LDL levels. Damask rose and the combination of saffron petals and damask rose decreased IGF-1 compared with the normal group (all p < 0.05).
Conclusions
Saffron and damask rose petals could have beneficial effects on improving the status of biochemical markers. The simultaneous use of saffron and damask rose may counteract the adverse effects of saffron on inflammatory indices.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Not applicable.
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Ethics approval and consent to participate: The study was approved by the Ethics Committee of Islamic Azad University, Tehran, Iran. IR.IAU.SRB.REC.1396.109.
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Reviews
- Swarna Prashana – faith in the embrace of research
- A review on the concept of aging in Ayurveda literature
- Ethno-pharmacology of Asaroon (Asarum europaeum L.) with special reference to Unani System of Medicine
- Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review
- The anti-cancer properties of neem (Azadirachta indica) through its antioxidant activity in the liver: its pharmaceutics and toxic dosage forms. A literature review
- The role of acupuncture for myofascial pain syndrome (MPS) in interventional pain management
- Research Articles
- Identification of phenolic compounds in the buds of Algerian Pistacia atlantica desf. Subsp. atlantica by antioxidant activity guided fractionation
- Optimization of water-based ultrasonic-microwave assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
- Proximate analysis, HPTLC finger print analysis and multi spectrometric analysis of Strychnos nux-vomica nuts
- Amelioration of sodium fluoride induced oxidative stress by Cynometra travancorica Bedd in mice
- The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements
- Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
- Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis
- The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism
- Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses
- Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
- Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats
- The effect of Cinnamomum cassia extract on oxidative stress in the liver and kidney of STZ-induced diabetic rats
- Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats
- Ameliorating activity of polyphenolic-rich extracts of Basella rubra L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats
- Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice
- The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance
- Anti-obesity effects of the n-butanol fraction of the methanolic leaf extract of Artemisia campestris from Tunisian pharmacopeia in male Wistar rats
- Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats
- Preventing SARS-CoV-2 transmission in the emergency department by implementing a separate pathway for patients with respiratory conditions
- Clinical significance of serum gonadotropin and androgen levels among Egyptian overweight/obese pubertal girls
- Preference between serum homocysteine and urinary periostin as early predictive biomarkers of renal dysfunction among uncontrolled diabetics
- Mizaj assessment in multiple sclerosis patients based on Persian Medicine
- Immediate effects of the practise of Sheethali pranayama on heart rate and blood pressure parameters in healthy volunteers
- Effects of 12 sessions of steam bath intervention on spirometry parameters among healthy adult volunteers
- The effects of psychological counseling and acupressure based on couple therapy procedure for alleviation of vomiting and nausea in pregnant women in Iran country
- “The immediate effect of neutral spinal compress on heart rate variability in hypertensive individuals”
- Effect of whole-body vibration after a resistance exercise bout on heart rate variability in hypertensive population
- Wet-cupping on calf muscles in polycystic ovary syndrome: a quasi-experimental study
- Auricular field nerve stimulation using the NSS-2 BRIDGE® device as an alternative to opioids following kidney donor surgery
- Evaluation of general body temperament and uterine dystemperament in amenorrhoea: a cross-sectional analytical study
- Short Communication
- Isolation, characterization, and antimicrobial activity of communic acid from Juniperus phoenicea
- Letter to the Editor
- Can silymarin ameliorate β-thalassemia major-induced osteopenia/osteoporosis?
- Case Reports
- Management of psoriasis with Ayurveda Panchakarma and Manibhadragula as Shodhana Rasayana – a case report
- Psychogenic pseudo-myasthenic ptosis – management with ayurvedic medicines and Smriti meditation
- Education Forum
- Tongue stretching: technique and clinical proposal
- Simulation-based ventilatory training for the caregivers at primary and rural health care workers in Central India for dealing with COVID-19 pandemic: recommendations
Articles in the same Issue
- Frontmatter
- Reviews
- Swarna Prashana – faith in the embrace of research
- A review on the concept of aging in Ayurveda literature
- Ethno-pharmacology of Asaroon (Asarum europaeum L.) with special reference to Unani System of Medicine
- Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review
- The anti-cancer properties of neem (Azadirachta indica) through its antioxidant activity in the liver: its pharmaceutics and toxic dosage forms. A literature review
- The role of acupuncture for myofascial pain syndrome (MPS) in interventional pain management
- Research Articles
- Identification of phenolic compounds in the buds of Algerian Pistacia atlantica desf. Subsp. atlantica by antioxidant activity guided fractionation
- Optimization of water-based ultrasonic-microwave assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
- Proximate analysis, HPTLC finger print analysis and multi spectrometric analysis of Strychnos nux-vomica nuts
- Amelioration of sodium fluoride induced oxidative stress by Cynometra travancorica Bedd in mice
- The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements
- Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
- Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis
- The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism
- Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses
- Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
- Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats
- The effect of Cinnamomum cassia extract on oxidative stress in the liver and kidney of STZ-induced diabetic rats
- Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats
- Ameliorating activity of polyphenolic-rich extracts of Basella rubra L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats
- Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice
- The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance
- Anti-obesity effects of the n-butanol fraction of the methanolic leaf extract of Artemisia campestris from Tunisian pharmacopeia in male Wistar rats
- Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats
- Preventing SARS-CoV-2 transmission in the emergency department by implementing a separate pathway for patients with respiratory conditions
- Clinical significance of serum gonadotropin and androgen levels among Egyptian overweight/obese pubertal girls
- Preference between serum homocysteine and urinary periostin as early predictive biomarkers of renal dysfunction among uncontrolled diabetics
- Mizaj assessment in multiple sclerosis patients based on Persian Medicine
- Immediate effects of the practise of Sheethali pranayama on heart rate and blood pressure parameters in healthy volunteers
- Effects of 12 sessions of steam bath intervention on spirometry parameters among healthy adult volunteers
- The effects of psychological counseling and acupressure based on couple therapy procedure for alleviation of vomiting and nausea in pregnant women in Iran country
- “The immediate effect of neutral spinal compress on heart rate variability in hypertensive individuals”
- Effect of whole-body vibration after a resistance exercise bout on heart rate variability in hypertensive population
- Wet-cupping on calf muscles in polycystic ovary syndrome: a quasi-experimental study
- Auricular field nerve stimulation using the NSS-2 BRIDGE® device as an alternative to opioids following kidney donor surgery
- Evaluation of general body temperament and uterine dystemperament in amenorrhoea: a cross-sectional analytical study
- Short Communication
- Isolation, characterization, and antimicrobial activity of communic acid from Juniperus phoenicea
- Letter to the Editor
- Can silymarin ameliorate β-thalassemia major-induced osteopenia/osteoporosis?
- Case Reports
- Management of psoriasis with Ayurveda Panchakarma and Manibhadragula as Shodhana Rasayana – a case report
- Psychogenic pseudo-myasthenic ptosis – management with ayurvedic medicines and Smriti meditation
- Education Forum
- Tongue stretching: technique and clinical proposal
- Simulation-based ventilatory training for the caregivers at primary and rural health care workers in Central India for dealing with COVID-19 pandemic: recommendations
