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Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats

  • Mojgan Behradnasab , Hassan Matinhomaei EMAIL logo and Mohamad Javad Rasaei
Published/Copyright: June 23, 2021
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 19 Issue 2

Abstract

Objectives

This animal study aimed to demonstrate the synergistic effect of high-intensity interval training (HIIT) and alcoholic extract of nettle on serum chemerin and beta cells function in type 2 diabetic male rats.

Methods

Thirty-two STZ-induced diabetic male Wistar rats were randomly divided into four groups including the control group, the supplemented group with 200 mg/day of nettle, the training group with five sessions per week of HIIT, and the group with combined nettle and HITT intervention. Body weight, lipid profile, beta cells function, and chemerin level were assessed after eight weeks of the intervention.

Results

The values of chemerin significantly decreased in combined HIIT and nettle intervention group compared to the control group (p=0.001). The levels of glucose and insulin decreased significantly in nettle group, exercise group, and combined HIIT and nettle group (p=0.001).

Conclusions

The present study found that intense interval exercise with the consumption of alcoholic extract of nettle can affect the performance of beta cells, glucose, and insulin. Future human studies are warranted.

Keywords: beta cells function; chemerin; fasting blood glucose; insulin; nettle
Corresponding author: Hassan Matinhomaei, Assistant Professor, Department of Physical Education & Sport Sciences, Faculty of Sport Science, Islamic Azad University, Tehran, Iran, Phone: +98 5588885, E-mail:

Acknowledgments

This study was conducted at the Islamic Azad University, Central Tehran Branch in 1396. We acknowledge staff at the participating schools for their excellent cooperation.

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethics statement: The study was approved by the ethics committee of Tehran Islamic Azad University (Ethical code: IR.MEDSAB.REC.1396.055).

References

1. Collaboration ERF. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 2011;364:829–41. https://doi.org/10.1056/nejmoa1008862.Search in Google Scholar

2. Bergman, R, Finegood, D, Kahn, S. The evolution of β‐cell dysfunction and insulin resistance in type 2 diabetes. Eur J Clin Invest 2002;32:35–45. https://doi.org/10.1046/j.1365-2362.32.s3.5.x.Search in Google Scholar PubMed

3. Vahid, F, Bourbour, F, Gholamalizadeh, M, Shivappa, N, Hébert, JR, Babakhani, K, et al.. A pro-inflammatory diet increases the likelihood of obesity and overweight in adolescent boys: a case–control study. Diabetol Metab Syndrome 2020;12:1–8. https://doi.org/10.1186/s13098-020-00536-0.Search in Google Scholar PubMed PubMed Central

4. Gholamalizadeh, M, Rastgoo, S, Doaei, S, Vahid, F, Malmir, H, Ashoori, N, et al.. Index of nutritional quality (INQ) and the risk of obesity in male adolescents: a case-control study. Biol Trace Elem Res 2020:1–6. https://doi.org/10.1007/s12011-020-02297-3.Search in Google Scholar PubMed

5. BourBour, F, Mirzaei Dahka, S, Gholamalizadeh, M, Akbari, ME, Shadnoush, M, Haghighi, M, et al.. Nutrients in prevention, treatment, and management of viral infections; special focus on Coronavirus. Arch Physiol Biochem 2020:1–10. https://doi.org/10.1080/13813455.2020.1791188.Search in Google Scholar PubMed

6. Doaei, S, Hajiesmaeil, M, Aminifard, A, Mosavi-Jarrahi, S, Akbari, M, Gholamalizadeh, M. Effects of gene polymorphisms of metabolic enzymes on the association between red and processed meat consumption and the development of colon cancer; a literature review. J Nutr Sci 2018;7. https://doi.org/10.1017/jns.2018.17.Search in Google Scholar PubMed PubMed Central

7. Greenberg, A, McDaniel, M. Identifying the links between obesity, insulin resistance and β‐cell function: potential role of adipocyte‐derived cytokines in the pathogenesis of type 2 diabetes. Eur J Clin Invest 2002;32:24–34. https://doi.org/10.1046/j.1365-2362.32.s3.4.x.Search in Google Scholar PubMed

8. Ferland, DJ, Watts, SW. Chemerin: a comprehensive review elucidating the need for cardiovascular research. Pharmacol Res 2015;99:351–61. https://doi.org/10.1016/j.phrs.2015.07.018.Search in Google Scholar PubMed PubMed Central

9. Kralisch, S, Weise, S, Sommer, G, Lipfert, J, Lossner, U, Bluher, M, et al.. Interleukin-1ß induces the novel adipokine chemerin in adipocytes in vitro. Regul Pept 2009;154:102–6. https://doi.org/10.1016/j.regpep.2009.02.010.Search in Google Scholar PubMed

10. Howarth, FC, Marzouqi, F, Al Saeedi, A, Hameed, RS, Adeghate, E. The effect of a heavy exercise program on the distribution of pancreatic hormones in the streptozotocin-induced diabetic rat. J Pancreas 2009;10:485–91.Search in Google Scholar

11. Takahashi, M, Takahashi, Y, Takahashi, K, Zolotaryov, FN, Hong, KS, Kitazawa, R, et al.. Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Lett 2008;582:573–8. https://doi.org/10.1016/j.febslet.2008.01.023.Search in Google Scholar PubMed

12. Shidfar, F, Bahrololumi, SS, Doaei, S, Mohammadzadeh, A, Gholamalizadeh, M, Mohammadimanesh, A. The effects of extra virgin olive oil on alanine aminotransferase, aspartate aminotransferase, and ultrasonographic indices of hepatic steatosis in nonalcoholic fatty liver disease patients undergoing low calorie diet. Can J Gastroenterol Hepatol 2018;2018. https://doi.org/10.1155/2018/1053710.Search in Google Scholar

13. Shaban, N, Kenno, K, Milne, K. The effects of a 2 week modified high intensity interval training program on the homeostatic model of insulin resistance (HOMA-IR) in adults with type 2 diabetes. J Sports Med Phys Fit 2014;54:203–9.Search in Google Scholar

14. Haghshenas, R, Jamshidi, Z, Doaei, S, Gholamalizadeh, M. The effect of a high-intensity interval training on plasma vitamin D level in obese male adolescents. Indian J Endocrinol Metab 2019;23:72. https://doi.org/10.4103/ijem.IJEM_267_18.Search in Google Scholar

15. Rezaei, S, Ashkar, F, Koohpeyma, F, Mahmoodi, M, Gholamalizadeh, M, Mazloom, Z, et al.. Hydroalcoholic extract of Achillea millefolium improved blood glucose, liver enzymes and lipid profile compared to metformin in streptozotocin-induced diabetic rats. Lipids Health Dis 2020;19:1–7. https://doi.org/10.1186/s12944-020-01228-4.Search in Google Scholar

16. Ashkar, F, Rezaei, S, Salahshoornezhad, S, Vahid, F, Gholamalizadeh, M, Dahka, SM, et al.. The Role of medicinal herbs in treatment of insulin resistance in patients with Polycystic Ovary Syndrome: a literature review. Biomol Concepts 2019;11:57–75. https://doi.org/10.1515/bmc-2020-0005.Search in Google Scholar

17. Lotfi, MH, Fallahzadeh, H, Rahmanian, M, Hosseinzadeh, M, Lashkardoost, H, Doaei, S, et al.. Association of food groups intake and physical activity with gestational diabetes mellitus in Iranian women. J Matern Fetal Neonatal Med 2020;33:3559–64. https://doi.org/10.1080/14767058.2019.1579189.Search in Google Scholar

18. Mehrdad, M, Doaei, S, Gholamalizadeh, M, Eftekhari, MH. The association between FTO genotype with macronutrients and calorie intake in overweight adults. Lipids Health Dis 2020;19:1–6. https://doi.org/10.1186/s12944-020-01372-x.Search in Google Scholar

19. Kavalalı, G, Tuncel, H, Göksel, S, Hatemi, H. Hypoglycemic activity of Urtica pilulifera in streptozotocin-diabetic rats. J Ethnopharmacol 2003;84:241–5.10.1016/S0378-8741(02)00315-XSearch in Google Scholar

20. Shapiro, K, Gong, WC. Natural products used for diabetes. J Am Pharmaceut Assoc 2002;42:217–26. https://doi.org/10.1331/108658002763508515.Search in Google Scholar PubMed

21. Høydal, MA, Wisløff, U, Kemi, OJ, Ellingsen, Ø. Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training. Eur J Prev Cardiol 2007;14:753–60.10.1097/HJR.0b013e3281eacef1Search in Google Scholar PubMed

22. Sarma Kataki, M, Murugamani, V, Rajkumari, A, Singh Mehra, P, Awasthi, D, Shankar Yadav, R. Antioxidant, hepatoprotective, and anthelmintic activities of methanol extract of urtica dioica L. Leaves. Pharmaceut Crop 2012;3. https://doi.org/10.2174/2210290601203010038.Search in Google Scholar

23. Stefanov, T, Blüher, M, Vekova, A, Bonova, I, Tzvetkov, S, Kurktschiev, D, et al.. Circulating chemerin decreases in response to a combined strength and endurance training. Endocrine 2014;45:382–91. https://doi.org/10.1007/s12020-013-0003-2.Search in Google Scholar PubMed

24. Saremi, A, Shavandi, N, Parastesh, M, Daneshmand, H. Twelve-week aerobic training decreases chemerin level and improves cardiometabolic risk factors in overweight and obese men. Asian J Sports Med 2010;1:151. https://doi.org/10.5812/asjsm.34860.Search in Google Scholar

25. Bozaoglu, K, Segal, D, Shields, KA, Cummings, N, Curran, JE, Comuzzie, AG, et al.. Chemerin is associated with metabolic syndrome phenotypes in a Mexican-American population. J Clin Endocrinol Metab 2009;94:3085–8. https://doi.org/10.1210/jc.2008-1833.Search in Google Scholar

26. Fathi, R, Mosayebi, Z, Nazarali, P, Aslani, S. Effect of resistance training on plasma levels of chemerin and Insulin in two groups of healthy and insulin resistance male rats. Research in Medicine 2015;38:207–13.Search in Google Scholar

27. Lloyd, JW, Evans, KA, Zerfass, KM, Holmstrup, ME, Kanaley, JA, Keslacy, S. Effect of an acute bout of aerobic exercise on chemerin levels in obese adults. Diabetes Metab Syndr: Clin Res Rev 2016;10:37–42. https://doi.org/10.1016/j.dsx.2015.04.010.Search in Google Scholar

28. Azimi, M, Marefati, H, Yousefzadeh, G, Mohajeri, M. The effect of aerobic exercise on plasma visfatin levels in men with type 2 diabetes treated with metformin. Daneshvar Med Basic Clin Res J 2012;20:17–24.Search in Google Scholar

29. Eizadi, M, Behboudi, L, Zahedmanesh, F, Afsharmand, Z. Effect of acute and chronic exercise on beta-cell function in diabetic patients. J Kashan Univ Med Sci 2012:15–9.Search in Google Scholar

30. Azizi, M, Tadib, V, Behpoor, N. The effect of aerobic exercise training on circulating levels of adipsin and insulin resistance among obese type-2 diabetic females. Jundishapur Scientific Med J 2016;15:433–42.Search in Google Scholar

31. Park, S, Hong, SM, Sung, SR. Exendin-4 and exercise promotes β-cell function and mass through IRS2 induction in islets of diabetic rats. Life Sci 2008;82:503–11. https://doi.org/10.1016/j.lfs.2007.12.018.Search in Google Scholar

32. Pinent, M, Castell, A, Baiges, I, Montagut, G, Arola, L, Ardévol, A. Bioactivity of flavonoids on insulin‐secreting cells. Compr Rev Food Sci Food Saf 2008;7:299–308. https://doi.org/10.1111/j.1541-4337.2008.00048.x.Search in Google Scholar

33. Tofighi, A, Babaei, S. The effects of separate and combined exercise and Nigella supplement on plasmatic levels of apelin and glucose in type 2 diabetes mouse. Studies in Medical Sciences 2016;27:10–8.Search in Google Scholar

34. Ghasemi, FSJH, Hosseini, A, Farakhi, F. The effect of swimming training on vaspin and glucose indices in diabetic rats. In: National Conference on New Research in Sport Sciences 2016.Search in Google Scholar

35. Kim, HJ, Lee, JS, Kim, CK. Effect of exercise training on muscle glucose transporter 4 protein and intramuscular lipid content in elderly men with impaired glucose tolerance. Eur J Appl Physiol 2004;93:353–8. https://doi.org/10.1007/s00421-004-1214-2.Search in Google Scholar

36. Das, M, Sarma, B, Rokeya, B, Parial, R, Nahar, N, Mosihuzzaman, M, et al.. Antihyperglycemic and antihyperlipidemic activity of Urtica dioica on type 2 diabetic model rats. J Diabetol 2011;2:1–6.10.4103/2078-7685.197792Search in Google Scholar

37. Iliya, I, Mohammed, B, Akuyam, S, Nok, A, Bauchi, Z, Tanko, M, et al.. Molecular mechanisms of insulin signaling. Sub-Saharan Afr J Med 2016;3:3. https://doi.org/10.4103/2384-5147.176267.Search in Google Scholar

38. Ramzany, N, Gaeini, A, Choobineh, S, Kordi, M, Hedayati, M. Changes of RBP-4 and insulin resistance after 8 weeks of aerobic training in type 2 diabetic rats. Metab Exerc Bioannual J 2016;5:89–98.Search in Google Scholar

39. Kazemi, F, Zahedi Asl, S. The correlation of plasma levels of apelin-13 with insulin resistance index and plasma leptin of diabetic male rats after 8-week aerobic exercise. J Arak Uni Med Sci 2015;18:51–60.Search in Google Scholar

40. M AP. The effect of a continuous and periodic exercise period on insulin receptor, Glut4 and AMPK receptor levels in diabetic male rats. In: Second National Conference on Sports and Diseases. 2016.Search in Google Scholar

41. Maiorana, A, O’Driscoll, G, Goodman, C, Taylor, R, Green, D. Combined aerobic and resistance exercise improves glycemic control and fitness in type 2 diabetes. Diabetes Res Clin Pract 2002;56:115–23. https://doi.org/10.1016/s0168-8227(01)00368-0.Search in Google Scholar

42. Shahraki, MR, Mirshekari, H, Shahraki, AR, Shahraki, E, Divband, KH. Effect of urtica dioica boiling on serum glucose, insulin and lipids in fructose-fed male rats; OFOGH-E-DANESH J 2008:10–5.Search in Google Scholar

43. Ahangarpour, A, Mohammadian, M, Dianat, M. Antidiabetic effect of hydroalcholic Urtica dioica leaf extract in male rats with fructose-induced insulin resistance. Iran J Med Sci 2012;37:181.Search in Google Scholar

44. Sigal, RJ, Kenny, GP, Boulé, NG, Wells, GA, Prud’homme, D, Fortier, M, et al.. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med 2007;147:357–69. https://doi.org/10.7326/0003-4819-147-6-200709180-00005.Search in Google Scholar PubMed

45. Albright, A, Franz, M, Hornsby, G, Kriska, A, Marrero, D, Ullrich, I, et al.. American College of Sports Medicine position stand. Exercise and type 2 diabetes. Med Sci Sports Exerc 2000;32:1345–60. https://doi.org/10.1097/00005768-200007000-00024.Search in Google Scholar PubMed

46. Snowling, NJ, Hopkins, WG. Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients: a meta-analysis. Diabetes Care 2006;29:2518–27. https://doi.org/10.2337/dc06-1317.Search in Google Scholar PubMed

47. Evans, EM, Racette, SB, Peterson, LR, Villareal, DT, Greiwe, JS, Holloszy, JO. Aerobic power and insulin action improve in response to endurance exercise training in healthy 77–87 yr olds. J Appl Physiol 2005;98:40–5. https://doi.org/10.1152/japplphysiol.00928.2004.Search in Google Scholar PubMed

48. Burgomaster, KA, Howarth, KR, Phillips, SM, Rakobowchuk, M, MacDonald, MJ, McGee, SL, et al.. Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. J Physiol 2008;586:151–60. https://doi.org/10.1113/jphysiol.2007.142109.Search in Google Scholar PubMed PubMed Central

49. Cuff, DJ, Meneilly, GS, Martin, A, Ignaszewski, A, Tildesley, HD, Frohlich, JJ. Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. Diabetes Care 2003;26:2977–82. https://doi.org/10.2337/diacare.26.11.2977.Search in Google Scholar PubMed

50. Golalipour, MJ, Ghafari, S, Kouri, V, Kestkar, AA. Proliferation of the β-cells of pancreas in diabetic rats treated with urtica dioica. Int J Morphol 2010;28:399–404. https://doi.org/10.4067/s0717-95022010000200011.Search in Google Scholar

51. Cetinus, E, Kilinc, M, Inanc, F, Kurutas, EB, Buzkan, N. The role of urtica dioica (urticaceae) in the prevention of oxidative stress caused by tourniquet application in rats. Tohoku J Exp Med 2005;205:215–21. https://doi.org/10.1620/tjem.205.215.Search in Google Scholar PubMed

52. Fakhraee, S, Jouyandeh, Z, Mehri, A, Larijani, B, Hasaniranjbar, S. Systematic review on the effectiveness and safety of nettle herb in treating diabetes. Iran J Diabetes & Lipid Disord 2012;12:507–23.Search in Google Scholar
Received: 2021-03-06
Accepted: 2021-06-11
Published Online: 2021-06-23

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Swarna Prashana – faith in the embrace of research
  4. A review on the concept of aging in Ayurveda literature
  5. Ethno-pharmacology of Asaroon (Asarum europaeum L.) with special reference to Unani System of Medicine
  6. Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review
  7. The anti-cancer properties of neem (Azadirachta indica) through its antioxidant activity in the liver: its pharmaceutics and toxic dosage forms. A literature review
  8. The role of acupuncture for myofascial pain syndrome (MPS) in interventional pain management
  9. Research Articles
  10. Identification of phenolic compounds in the buds of Algerian Pistacia atlantica desf. Subsp. atlantica by antioxidant activity guided fractionation
  11. Optimization of water-based ultrasonic-microwave assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
  12. Proximate analysis, HPTLC finger print analysis and multi spectrometric analysis of Strychnos nux-vomica nuts
  13. Amelioration of sodium fluoride induced oxidative stress by Cynometra travancorica Bedd in mice
  14. The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements
  15. Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
  16. Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis
  17. The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism
  18. Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses
  19. Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
  20. Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats
  21. The effect of Cinnamomum cassia extract on oxidative stress in the liver and kidney of STZ-induced diabetic rats
  22. Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats
  23. Ameliorating activity of polyphenolic-rich extracts of Basella rubra L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats
  24. Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice
  25. The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance
  26. Anti-obesity effects of the n-butanol fraction of the methanolic leaf extract of Artemisia campestris from Tunisian pharmacopeia in male Wistar rats
  27. Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats
  28. Preventing SARS-CoV-2 transmission in the emergency department by implementing a separate pathway for patients with respiratory conditions
  29. Clinical significance of serum gonadotropin and androgen levels among Egyptian overweight/obese pubertal girls
  30. Preference between serum homocysteine and urinary periostin as early predictive biomarkers of renal dysfunction among uncontrolled diabetics
  31. Mizaj assessment in multiple sclerosis patients based on Persian Medicine
  32. Immediate effects of the practise of Sheethali pranayama on heart rate and blood pressure parameters in healthy volunteers
  33. Effects of 12 sessions of steam bath intervention on spirometry parameters among healthy adult volunteers
  34. The effects of psychological counseling and acupressure based on couple therapy procedure for alleviation of vomiting and nausea in pregnant women in Iran country
  35. “The immediate effect of neutral spinal compress on heart rate variability in hypertensive individuals”
  36. Effect of whole-body vibration after a resistance exercise bout on heart rate variability in hypertensive population
  37. Wet-cupping on calf muscles in polycystic ovary syndrome: a quasi-experimental study
  38. Auricular field nerve stimulation using the NSS-2 BRIDGE® device as an alternative to opioids following kidney donor surgery
  39. Evaluation of general body temperament and uterine dystemperament in amenorrhoea: a cross-sectional analytical study
  40. Short Communication
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https://doi.org/10.1515/jcim-2021-0103
Keywords for this article
beta cells function; chemerin; fasting blood glucose; insulin; nettle

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Swarna Prashana – faith in the embrace of research
  4. A review on the concept of aging in Ayurveda literature
  5. Ethno-pharmacology of Asaroon (Asarum europaeum L.) with special reference to Unani System of Medicine
  6. Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review
  7. The anti-cancer properties of neem (Azadirachta indica) through its antioxidant activity in the liver: its pharmaceutics and toxic dosage forms. A literature review
  8. The role of acupuncture for myofascial pain syndrome (MPS) in interventional pain management
  9. Research Articles
  10. Identification of phenolic compounds in the buds of Algerian Pistacia atlantica desf. Subsp. atlantica by antioxidant activity guided fractionation
  11. Optimization of water-based ultrasonic-microwave assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
  12. Proximate analysis, HPTLC finger print analysis and multi spectrometric analysis of Strychnos nux-vomica nuts
  13. Amelioration of sodium fluoride induced oxidative stress by Cynometra travancorica Bedd in mice
  14. The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements
  15. Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
  16. Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis
  17. The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism
  18. Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses
  19. Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
  20. Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats
  21. The effect of Cinnamomum cassia extract on oxidative stress in the liver and kidney of STZ-induced diabetic rats
  22. Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats
  23. Ameliorating activity of polyphenolic-rich extracts of Basella rubra L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats
  24. Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice
  25. The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance
  26. Anti-obesity effects of the n-butanol fraction of the methanolic leaf extract of Artemisia campestris from Tunisian pharmacopeia in male Wistar rats
  27. Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats
  28. Preventing SARS-CoV-2 transmission in the emergency department by implementing a separate pathway for patients with respiratory conditions
  29. Clinical significance of serum gonadotropin and androgen levels among Egyptian overweight/obese pubertal girls
  30. Preference between serum homocysteine and urinary periostin as early predictive biomarkers of renal dysfunction among uncontrolled diabetics
  31. Mizaj assessment in multiple sclerosis patients based on Persian Medicine
  32. Immediate effects of the practise of Sheethali pranayama on heart rate and blood pressure parameters in healthy volunteers
  33. Effects of 12 sessions of steam bath intervention on spirometry parameters among healthy adult volunteers
  34. The effects of psychological counseling and acupressure based on couple therapy procedure for alleviation of vomiting and nausea in pregnant women in Iran country
  35. “The immediate effect of neutral spinal compress on heart rate variability in hypertensive individuals”
  36. Effect of whole-body vibration after a resistance exercise bout on heart rate variability in hypertensive population
  37. Wet-cupping on calf muscles in polycystic ovary syndrome: a quasi-experimental study
  38. Auricular field nerve stimulation using the NSS-2 BRIDGE® device as an alternative to opioids following kidney donor surgery
  39. Evaluation of general body temperament and uterine dystemperament in amenorrhoea: a cross-sectional analytical study
  40. Short Communication
  41. Isolation, characterization, and antimicrobial activity of communic acid from Juniperus phoenicea
  42. Letter to the Editor
  43. Can silymarin ameliorate β-thalassemia major-induced osteopenia/osteoporosis?
  44. Case Reports
  45. Management of psoriasis with Ayurveda Panchakarma and Manibhadragula as Shodhana Rasayana – a case report
  46. Psychogenic pseudo-myasthenic ptosis – management with ayurvedic medicines and Smriti meditation
  47. Education Forum
  48. Tongue stretching: technique and clinical proposal
  49. Simulation-based ventilatory training for the caregivers at primary and rural health care workers in Central India for dealing with COVID-19 pandemic: recommendations
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