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Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis

  • Maddison Hunter ORCID logo EMAIL logo , Andrew McKune , Kellie Toohey ORCID logo and Nenad Naumovski
Published/Copyright: September 29, 2021
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 19 Issue 2

Abstract

Objectives

Oral mucositis is a debilitating oncology treatment side effect, with honey identified as a viable management option due to established wound-healing abilities. However, effects of saliva on properties attributed to honey’s wound-healing abilities is unknown. Therefore, this study aimed to identify interactions between saliva, and antioxidant characteristics and pH of honey.

Methods

Saliva was collected from 15 healthy participants (Females n=9; mean age=34.1 ± 11.2 years). Centrifuged salivary supernatant, whole saliva, and water were independently used to dilute commercial Australian honeys (n=42). Antioxidant characteristics (DPPH and FRAP) and pH of diluted honeys were analysed, and differences between dilution conditions were determined.

Results

Honey and saliva dilutions increased antioxidant characteristics compared to water, and addition of honey to saliva reduced pH compared with saliva alone. There were significant differences between dilutions for FRAP and pH, and water and salivary conditions for DPPH (p<0.001). No difference was observed between salivary conditions for DPPH (p=0.931), suggesting smaller cells remaining in the supernatant possess antioxidant abilities. However, differences observed for FRAP suggest precipitable molecules, including epithelial and food debris, could provide additional antioxidant power.

Conclusions

The addition of saliva to honey may support properties attributed to honey’s wound-healing abilities and should be considered in the context of oral mucositis management.

Keywords: antioxidant; honey; human saliva; oral mucositis management; pH
Corresponding author: Maddison Hunter, Faculty of Health, Discipline of Nutrition and Dietetics, University of Canberra, ACT, 2617, Australia, E-mail:

Funding source: Australian Government Research Training Program Scholarship

  1. Research funding: This research was supported by an Australian Government Research Training Program Scholarship for M.H.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The research related to human use has complied with all the relevant national regulations, institutional policies, and in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ Institutional Review Board or equivalent committee (University of Canberra Human Research Ethics Committee UCHREC:20180293).

References

1. Sonis, ST. Mucositis: the impact, biology and therapeutic opportunities of oral mucositis. Oral Oncol 2009;45:1015–20. https://doi.org/10.1016/j.oraloncology.2009.08.006.Search in Google Scholar PubMed

2. Rodríguez-Caballero, A, Torres-Lagares, D, Robles-García, M, Pachón-Ibáñez, J, González-Padilla, D, Gutiérrez-Pérez, JL. Cancer treatment-induced oral mucositis: a critical review. Int J Oral Maxillofac Surg 2012;41:225–38. https://doi.org/10.1016/j.ijom.2011.10.011.Search in Google Scholar PubMed

3. Bossi, P, Giusti, R, Tarsitano, A, Airoldi, M, De Sanctis, V, Caspiani, O, et al.. The point of pain in head and neck cancer. Crit Rev Oncol Hematol 2019;138:51–9. https://doi.org/10.1016/j.critrevonc.2019.04.001.Search in Google Scholar PubMed

4. Franco, P, Martini, S, Di Muzio, J, Cavallin, C, Arcadipane, F, Rampino, M, et al.. Prospective assessment of oral mucositis and its impact on quality of life and patient-reported outcomes during radiotherapy for head and neck cancer. Med Oncol 2017;34:81. https://doi.org/10.1007/s12032-017-0950-1.Search in Google Scholar PubMed

5. Subramaniam, N, Muthukrishnan, A. Oral mucositis and microbial colonization in oral cancer patients undergoing radiotherapy and chemotherapy: a prospective analysis in a tertiary care dental hospital. J Investig Clin Dent 2019;10:e12454. https://doi.org/10.1111/jicd.12454.Search in Google Scholar PubMed

6. Sonis, ST. Pathobiology of oral mucositis: novel insights and opportunities. J Support Oncol 2007;5:3–11.Search in Google Scholar

7. Elad, S, Cheng, KKF, Lalla, RV, Yarom, N, Hong, C, Logan, RM, et al.. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 2020;126:4423–31. https://doi.org/10.1002/cncr.33100.Search in Google Scholar PubMed PubMed Central

8. De Sanctis, V, Bossi, P, Sanguineti, G, Trippa, F, Ferrari, D, Bacigalupo, A, et al.. Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies: literature review and consensus statements. Crit Rev Oncol Hematol 2016;100:147–66. https://doi.org/10.1016/j.critrevonc.2016.01.010.Search in Google Scholar PubMed

9. Nicolatou-Galitis, O, Bossi, P, Orlandi, E, René-Jean, B. The role of benzydamine in prevention and treatment of chemoradiotherapy-induced mucositis. Support Care Canc 2021. https://doi.org/10.1007/s00520-021-06048-5 [Epub ahead of print].Search in Google Scholar PubMed PubMed Central

10. Logan, RM, Al-Azri, AR, Bossi, P, Stringer, AM, Joy, JK, Soga, Y, et al.. Systematic review of growth factors and cytokines for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Canc 2020;28:2485–98. https://doi.org/10.1007/s00520-019-05170-9.Search in Google Scholar PubMed

11. Amanat, A, Ahmed, A, Kazmi, A, Aziz, B. The effect of honey on radiation-induced oral mucositis in head and neck cancer patients. Indian J Palliat Care 2017;23:317–20. https://doi.org/10.4103/ijpc.ijpc_146_16.Search in Google Scholar PubMed PubMed Central

12. Biswal, BM, Zakaria, A, Ahmad, NM. Topical application of honey in the management of radiation mucositis. A preliminary study. Support Care Canc 2003;11:242–8. https://doi.org/10.1007/s00520-003-0443-y.Search in Google Scholar PubMed

13. Howlader, D, Singh, V, Mohammad, S, Gupta, S, Pal, U, Pal, M. Effect of topical application of pure honey in chemo-radiation-induced mucositis and its clinical benefits in improving quality of life in patients of oral squamous cell carcinoma. J Maxillofac Oral Surg 2019;18:73–9. https://doi.org/10.1007/s12663-017-1077-9.Search in Google Scholar PubMed PubMed Central

14. Jayachandran, S, Balaji, N. Evaluating the effectiveness of topical application of natural honey and benzydamine hydrochloride in the management of radiation mucositis. Indian J Palliat Care 2012;18:190–5. https://doi.org/10.4103/0973-1075.105689.Search in Google Scholar PubMed PubMed Central

15. Jayalekshmi, J, Lakshmi, R, Mukerji, A. Honey on oral mucositis: a randomized controlled trial. Gulf J Oncol 2016;1:30–7.Search in Google Scholar

16. Khanal, B, Baliga, M, Uppal, N. Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study. Int J Oral Maxillofac Surg 2010;39:1181–5. https://doi.org/10.1016/j.ijom.2010.05.014.Search in Google Scholar PubMed

17. Maiti, PK, Ray, A, Mitra, TN, Jana, U, Bhattacharya, J, Ganguly, S. The effect of honey on mucositis induced by chemoradiation in head and neck cancer. J Indian Med Assoc 2012;110:453–6.Search in Google Scholar

18. Motallebnejad, M, Akram, S, Moghadamnia, A, Moulana, Z, Omidi, S. The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial. J Contemp Dent Pract 2008;9:40–7. https://doi.org/10.5005/jcdp-9-3-40.Search in Google Scholar

19. Rao, S, Hegde, SK, Rao, P, Dinkar, C, Thilakchand, KR, George, T, et al.. Honey mitigates radiation-induced oral mucositis in head and neck cancer patients without affecting the tumor response. Foods 2017;6:77. https://doi.org/10.3390/foods6090077.Search in Google Scholar PubMed PubMed Central

20. Rashad, U, Al-Gezawy, S, El-Gezawy, E, Azzaz, A. Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer. J Laryngol Otol 2009;123:223. https://doi.org/10.1017/s0022215108002478.Search in Google Scholar PubMed

21. da Silva, PM, Gauche, C, Gonzaga, LV, Costa, ACO, Fett, R. Honey: chemical composition, stability and authenticity. Food Chem 2016;196:309–23. https://doi.org/10.1016/j.foodchem.2015.09.051.Search in Google Scholar PubMed

22. Liu, J-R, Ye, Y-L, Lin, T-Y, Wang, Y-W, Peng, C-C. Effect of floral sources on the antioxidant, antimicrobial, and anti-inflammatory activities of honeys in Taiwan. Food Chem 2013;139:938–43. https://doi.org/10.1016/j.foodchem.2013.02.015.Search in Google Scholar PubMed

23. Schramm, DD, Karim, M, Schrader, HR, Holt, RR, Cardetti, M, Keen, CL. Honey with high levels of antioxidants can provide protection to healthy human subjects. J Agric Food Chem 2003;51:1732–5. https://doi.org/10.1021/jf025928k.Search in Google Scholar PubMed

24. Ahmed, S, Sulaiman, SA, Baig, AA, Ibrahim, M, Liaqat, S, Fatima, S, et al.. Honey as a potential natural antioxidant medicine: an insight into its molecular mechanisms of action. Oxid Med Cell Longev 2018;2018:8367846. https://doi.org/10.1155/2018/8367846.Search in Google Scholar PubMed PubMed Central

25. Cimpoiu, C, Hosu, A, Miclaus, V, Puscas, A. Determination of the floral origin of some Romanian honeys on the basis of physical and biochemical properties. Spectrochim Acta A Mol Biomol Spectrosc 2013;100:149–54. https://doi.org/10.1016/j.saa.2012.04.008.Search in Google Scholar PubMed

26. Al-Ghamdi, AA, Ansari, MJ. Biological and therapeutic roles of Saudi Arabian honey: a comparative review. J King Saud Univ Sci 2021;33:101329. https://doi.org/10.1016/j.jksus.2020.101329.Search in Google Scholar

27. Combarros-Fuertes, P, Fresno, JM, Estevinho, MM, Sousa-Pimenta, M, Tornadijo, ME, Estevinho, LM. Honey: another alternative in the fight against antibiotic-resistant bacteria? Antibiotics 2020;9:774. https://doi.org/10.3390/antibiotics9110774.Search in Google Scholar PubMed PubMed Central

28. Bang, LM, Buntting, C, Molan, P. The effect of dilution on the rate of hydrogen peroxide production in honey and its implications for wound healing. J Altern Compl Med 2003;9:267–73. https://doi.org/10.1089/10755530360623383.Search in Google Scholar PubMed

29. Leyva-Jimenez, FJ, Lozano-Sanchez, J, Borras-Linares, I, Cadiz-Gurrea, ML, Mahmoodi-Khaledi, E. Potential antimicrobial activity of honey phenolic compounds against gram positive and gram negative bacteria. LWT – Food Sci Technol. 2019;101:236–45. https://doi.org/10.1016/j.lwt.2018.11.015.Search in Google Scholar

30. Hadagali, MD, Chua, LS. The anti-inflammatory and wound healing properties of honey. Eur Food Res Tech 2014;239:1003–14. https://doi.org/10.1007/s00217-014-2297-6.Search in Google Scholar

31. Lima, ICGS, de Fátima Souto Maior, L, Gueiros, LAM, Leão, JC, Higino, JS, Carvalho, AAT. Clinical applicability of natural products for prevention and treatment of oral mucositis: a systematic review and meta-analysis. Clin Oral Invest 2021;25:4115–24. https://doi.org/10.1007/s00784-020-03743-1.Search in Google Scholar PubMed

32. Vandamme, L, Heyneman, A, Hoeksema, H, Verbelen, J, Monstrey, S. Honey in modern wound care: a systematic review. Burns 2013;39:1514–25. https://doi.org/10.1016/j.burns.2013.06.014.Search in Google Scholar PubMed

33. Bertoncelj, J, Doberšek, U, Jamnik, M, Golob, T. Evaluation of the phenolic content, antioxidant activity and colour of Slovenian honey. Food Chem 2007;105:822–8. https://doi.org/10.1016/j.foodchem.2007.01.060.Search in Google Scholar

34. Aazza, S, Lyoussi, B, Antunes, D, Miguel, MG. Physicochemical characterization and antioxidant activity of 17 commercial Moroccan honeys. Int J Food Sci Nutr 2014;65:449–57. https://doi.org/10.3109/09637486.2013.873888.Search in Google Scholar PubMed

35. Azonwade, FE, Paraïso, A, Agbangnan Dossa, CP, Dougnon, VT, N’tcha, C, Mousse, W, et al.. Physicochemical characteristics and microbiological quality of honey produced in Benin. J Food Qual 2018;2018:1896057. https://doi.org/10.1155/2018/1896057.Search in Google Scholar

36. Chojnowska, S, Baran, T, Wilińska, I, Sienicka, P, Cabaj-Wiater, I, Knaś, M. Human saliva as a diagnostic material. Adv Med Sci 2018;63:185–91. https://doi.org/10.1016/j.advms.2017.11.002.Search in Google Scholar PubMed

37. Baliga, S, Muglikar, S, Kale, R. Salivary pH: a diagnostic biomarker. J Indian Soc Periodontol 2013;17:461–5. https://doi.org/10.4103/0972-124x.118317.Search in Google Scholar PubMed PubMed Central

38. Loke, C, Lee, J, Sander, S, Mei, L, Farella, M. Factors affecting intra-oral pH–a review. J Oral Rehabil 2016;43:778–85. https://doi.org/10.1111/joor.12429.Search in Google Scholar PubMed

39. Tartaglia, GM, Gagliano, N, Zarbin, L, Tolomeo, G, Sforza, C. Antioxidant capacity of human saliva and periodontal screening assessment in healthy adults. Arch Oral Biol 2017;78:34–8. https://doi.org/10.1016/j.archoralbio.2017.02.003.Search in Google Scholar PubMed

40. Lynge Pedersen, AM, Belstrøm, D. The role of natural salivary defences in maintaining a healthy oral microbiota. J Dent 2019;80:S3–12. https://doi.org/10.1016/j.jdent.2018.08.010.Search in Google Scholar PubMed

41. Brand, HS, Ligtenberg, AJ, Veerman, EC. Saliva and wound healing. Monogr Oral Sci 2014;24:52–60. https://doi.org/10.1159/000358784.Search in Google Scholar PubMed

42. Salimetrics, LLC, SalivaBio, LLC. Saliva collection and handling advice. Carlsbad, USA: Salimetrics LLC; 2015.Search in Google Scholar

43. Zhang, YF, Zheng, J, Zheng, L, Zhou, ZR. Influence of centrifugation treatment on the lubricating properties of human whole saliva. Biosurf Biotribol 2016;2:95–101. https://doi.org/10.1016/j.bsbt.2016.09.001.Search in Google Scholar

44. Beretta, G, Granata, P, Ferrero, M, Orioli, M, Facino, RM. Standardization of antioxidant properties of honey by a combination of spectrophotometric/fluorimetric assays and chemometrics. Anal Chim Acta 2005;533:185–91. https://doi.org/10.1016/j.aca.2004.11.010.Search in Google Scholar

45. Thaipong, K, Boonprakob, U, Crosby, K, Cisneros-Zevallos, L, Byrne, DH. Comparison of ABTS, DPPH, FRAP, and ORAC assays for estimating antioxidant activity from guava fruit extracts. J Food Compos Anal 2006;19:669–75. https://doi.org/10.1016/j.jfca.2006.01.003.Search in Google Scholar

46. Aumeeruddy, MZ, Aumeeruddy-Elalfi, Z, Neetoo, H, Zengin, G, Blom van Staden, A, Fibrich, B, et al.. Pharmacological activities, chemical profile, and physicochemical properties of raw and commercial honey. Biocatal Agric Biotechnol 2019;18:101005. https://doi.org/10.1016/j.bcab.2019.01.043.Search in Google Scholar

47. Vinay, V. Salivary antioxidant status following radiotherapy in patients with head and neck cancer. Int J Anat Res 2019;7:6793–9.10.16965/ijar.2019.227Search in Google Scholar

48. Buglione, M, Cavagnini, R, Di Rosario, F, Maddalo, M, Vassalli, L, Grisanti, S, et al.. Oral toxicity management in head and neck cancer patients treated with chemotherapy and radiation: xerostomia and trismus (Part 2). Literature review and consensus statement. Crit Rev Oncol Hematol 2016;102:47–54. https://doi.org/10.1016/j.critrevonc.2016.03.012.Search in Google Scholar PubMed

49. González-Hernández, JM, Franco, L, Colomer-Poveda, D, Martinez-Subiela, S, Cugat, R, Cerón, JJ, et al.. Influence of sampling conditions, salivary flow, and total protein content in uric acid measurements in saliva. Antioxidants 2019;8:389. https://doi.org/10.3390/antiox8090389.Search in Google Scholar PubMed PubMed Central

50. Biehler, E, Mayer, F, Hoffmann, L, Krause, E, Bohn, T. Comparison of 3 spectrophotometric methods for carotenoid determination in frequently consumed fruits and vegetables. J Food Sci 2010;75:C55–61. https://doi.org/10.1111/j.1750-3841.2009.01417.x.Search in Google Scholar PubMed

Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jcim-2021-0280).

Received: 2021-06-30
Accepted: 2021-09-15
Published Online: 2021-09-29

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jcim-2021-0280
Keywords for this article
antioxidant; honey; human saliva; oral mucositis management; pH

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Swarna Prashana – faith in the embrace of research
  4. A review on the concept of aging in Ayurveda literature
  5. Ethno-pharmacology of Asaroon (Asarum europaeum L.) with special reference to Unani System of Medicine
  6. Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review
  7. The anti-cancer properties of neem (Azadirachta indica) through its antioxidant activity in the liver: its pharmaceutics and toxic dosage forms. A literature review
  8. The role of acupuncture for myofascial pain syndrome (MPS) in interventional pain management
  9. Research Articles
  10. Identification of phenolic compounds in the buds of Algerian Pistacia atlantica desf. Subsp. atlantica by antioxidant activity guided fractionation
  11. Optimization of water-based ultrasonic-microwave assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
  12. Proximate analysis, HPTLC finger print analysis and multi spectrometric analysis of Strychnos nux-vomica nuts
  13. Amelioration of sodium fluoride induced oxidative stress by Cynometra travancorica Bedd in mice
  14. The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements
  15. Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
  16. Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis
  17. The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism
  18. Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses
  19. Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
  20. Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats
  21. The effect of Cinnamomum cassia extract on oxidative stress in the liver and kidney of STZ-induced diabetic rats
  22. Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats
  23. Ameliorating activity of polyphenolic-rich extracts of Basella rubra L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats
  24. Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice
  25. The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance
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  27. Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats
  28. Preventing SARS-CoV-2 transmission in the emergency department by implementing a separate pathway for patients with respiratory conditions
  29. Clinical significance of serum gonadotropin and androgen levels among Egyptian overweight/obese pubertal girls
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