Home Medicine Wet-cupping on calf muscles in polycystic ovary syndrome: a quasi-experimental study
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Wet-cupping on calf muscles in polycystic ovary syndrome: a quasi-experimental study

  • Azam Meyari , Mojgan Tansaz , Fahimeh Ramezani Tehrani , Roshanak Mokaberinejad , Mahdi Biglarkhani EMAIL logo , Razieh Bidhendi Yarandi and Mohammad Fayaz
Published/Copyright: May 14, 2021
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 19 Issue 2

Abstract

Objectives

Current modalities for treating polycystic ovary syndrome (PCOS) are not curative and using them for a long period is associated with adverse effects. According to Persian Medicine recommendations, wet cupping on calf muscles can induce menstrual bleeding. In the present study, the effect of wet-cupping (traditional bleeding from capillary vessels) was assessed on menstrual cycles (as primary outcome), hirsutism, and laboratory manifestation of PCOS.

Methods

A quasi-experimental study was conducted from 2016/5/21 until 2017/5/20 on 66 PCOS women within the age range of 20–40 years and a menstrual interval of at least 60 days during the last year. Participants’ calf muscles were cupped on day 26 of their last menstruation cycle following the Persian Medicine recommendations. They were followed for 12 weeks and a menstruation history and physical examination was done twice (4 and 12 weeks after wet cupping). Insulin Resistance (IR) and Free Androgen Index (FAI) were evaluated at baseline and end of the study.

Results

Wet-cupping on calf muscles significantly improved menstrual cycles’ frequency 0.37(95% CI: 0.13, 0.51), p-value=0.001 and hirsutism after 4 and 12 weeks of intervention were −1.9 (95% CI: −2.5, −0.5), p-value<0.001 and −1.4(95% CI: −2.1, −0.8), p-value<0.001, respectively. While it was not significant in changing the IR and FAI. About 33% of participants suffered from mild temporary discomforts (which were resolved within a few minutes of rest) and 9% reported mild long-term side effects.

Conclusions

It is considered that wet-cupping on calf muscles can be propounded as an optional treatment of PCOS for those not willing to use chemical medication.

Keywords: insulin resistance; Persian Medicine; polycystic ovary syndrome (PCOS); wet-cupping
Corresponding author: Mahdi Biglarkhani, MD, PhD, Assistant Professor, Department of Persian Medicine, School of Medicine, Hamadan University of medical sciences, Shahid Fahmideh Street, Hamadan, Iran, Phone: 0098 9183111268, Fax: 0098 8138380246, E-mail:

Funding source: Vice chancellor for research, Shahid Beheshti University of Medical Sciences

Award Identifier / Grant number: 178

Acknowledgments

This paper was supported by the School of Persian Medicine, Shahid Beheshti University of Medical Sciences, Iran (grant number: 178). The authors acknowledge with much appreciation the important role of the participants in the study. We also gratefully thank the Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences.

  1. Research funding: This study was supported by a grant from the Shahid Beheshti University of Medical Sciences (grant number: 178) that funded in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The Ethics Committee of Shahid Beheshti University of Medical Sciences deemed and approved the this study (license No. IR.SBMU.REC.1395.34).

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jcim-2020-0458).

Received: 2020-11-22
Accepted: 2021-03-24
Published Online: 2021-05-14

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jcim-2020-0458
Keywords for this article
insulin resistance; Persian Medicine; polycystic ovary syndrome (PCOS); wet-cupping

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Swarna Prashana – faith in the embrace of research
  4. A review on the concept of aging in Ayurveda literature
  5. Ethno-pharmacology of Asaroon (Asarum europaeum L.) with special reference to Unani System of Medicine
  6. Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review
  7. The anti-cancer properties of neem (Azadirachta indica) through its antioxidant activity in the liver: its pharmaceutics and toxic dosage forms. A literature review
  8. The role of acupuncture for myofascial pain syndrome (MPS) in interventional pain management
  9. Research Articles
  10. Identification of phenolic compounds in the buds of Algerian Pistacia atlantica desf. Subsp. atlantica by antioxidant activity guided fractionation
  11. Optimization of water-based ultrasonic-microwave assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
  12. Proximate analysis, HPTLC finger print analysis and multi spectrometric analysis of Strychnos nux-vomica nuts
  13. Amelioration of sodium fluoride induced oxidative stress by Cynometra travancorica Bedd in mice
  14. The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements
  15. Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
  16. Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis
  17. The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism
  18. Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses
  19. Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
  20. Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats
  21. The effect of Cinnamomum cassia extract on oxidative stress in the liver and kidney of STZ-induced diabetic rats
  22. Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats
  23. Ameliorating activity of polyphenolic-rich extracts of Basella rubra L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats
  24. Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice
  25. The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance
  26. Anti-obesity effects of the n-butanol fraction of the methanolic leaf extract of Artemisia campestris from Tunisian pharmacopeia in male Wistar rats
  27. Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats
  28. Preventing SARS-CoV-2 transmission in the emergency department by implementing a separate pathway for patients with respiratory conditions
  29. Clinical significance of serum gonadotropin and androgen levels among Egyptian overweight/obese pubertal girls
  30. Preference between serum homocysteine and urinary periostin as early predictive biomarkers of renal dysfunction among uncontrolled diabetics
  31. Mizaj assessment in multiple sclerosis patients based on Persian Medicine
  32. Immediate effects of the practise of Sheethali pranayama on heart rate and blood pressure parameters in healthy volunteers
  33. Effects of 12 sessions of steam bath intervention on spirometry parameters among healthy adult volunteers
  34. The effects of psychological counseling and acupressure based on couple therapy procedure for alleviation of vomiting and nausea in pregnant women in Iran country
  35. “The immediate effect of neutral spinal compress on heart rate variability in hypertensive individuals”
  36. Effect of whole-body vibration after a resistance exercise bout on heart rate variability in hypertensive population
  37. Wet-cupping on calf muscles in polycystic ovary syndrome: a quasi-experimental study
  38. Auricular field nerve stimulation using the NSS-2 BRIDGE® device as an alternative to opioids following kidney donor surgery
  39. Evaluation of general body temperament and uterine dystemperament in amenorrhoea: a cross-sectional analytical study
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  44. Case Reports
  45. Management of psoriasis with Ayurveda Panchakarma and Manibhadragula as Shodhana Rasayana – a case report
  46. Psychogenic pseudo-myasthenic ptosis – management with ayurvedic medicines and Smriti meditation
  47. Education Forum
  48. Tongue stretching: technique and clinical proposal
  49. Simulation-based ventilatory training for the caregivers at primary and rural health care workers in Central India for dealing with COVID-19 pandemic: recommendations
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