Startseite The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance
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The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance

  • Samruddhi Kavishwar , Mrinal Sanaye ORCID logo EMAIL logo , Monisha Nair , Mukesh Chawda , Viplav Kshirsagar ORCID logo und Yogesh A. Kulkarni ORCID logo
Veröffentlicht/Copyright: 15. Juli 2021
Journal of Complementary and Integrative Medicine
Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 19 Heft 2

Abstract

Objectives

Madhumeha Kusumakar Rasa (MKR) is an Ayurved formulation having a strong pharmacological base for diabetes management. This study aimed to validate MKR's efficacy in dexamethasone-induced insulin resistance (IR).

Methods

Albino Wistar rats were divided into four groups. Group 1 served as the normal control, Group 2 received dexamethasone 1.5 mg/kg (i.p.), Group 3 received dexamethasone and metformin 200 mg/kg (p.o.), and Group 4 received dexamethasone and MKR 236 mg/kg (p.o.). Animals were evaluated for serum glucose levels and glucose tolerance, serum insulin, Homeostatic model assessment of insulin resistance (HOMA-IR), Homeostatic model assessment of insulin sensitivity (HOMA-IS), fasting glucose to insulin ratio (FGIR), and lipid parameters. Pancreas, liver, and kidneys were evaluated for reduced Glutathione (GSH) and Malondialdehyde (MDA) levels. These tissues were also evaluated for histopathological changes.

Results

MKR showed significant improvement in serum glucose and glucose tolerance, serum insulin and HOMA-IR, HOMA-IS, and FGIR. It also showed a significant improvement in lipid parameters as compared to the dexamethasone-treated group. It prevented depletion of GSH levels and elevation in MDA levels. These effects were supported by histopathological analysis.

Conclusions

MKR treatment significantly attenuated dexamethasone-induced IR. This study validates the mechanism of the anti-diabetic potential of MKR.

Keywords: ayurved; ethnopharmacology; insulin resistance; phytomedicine; type 2 diabetes mellitus
Corresponding author: Dr. Mrinal Sanaye, Department of Pharmacology, Prin. K. M. Kundnani, College of Pharmacy, Mumbai 400005, India, Phone: +91 7977531687, E-mail:

Funding source: Shree Dhootapapeshwar Ltd.

  1. Research funding: The work was funded by Shree Dhootapapeshwar Limited, Mumbai, India.

  2. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Competing interests: Two authors are from Shree Dhootapapeshwar Limited, which have also funded the study. The other authors declare no conflict of interest.

  4. Ethical statement: The study protocol was approved by the Institutional Animal Ethics Committee (Protocol number-KMKCP/IAEC/181903).

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Received: 2021-02-28
Accepted: 2021-07-03
Published Online: 2021-07-15

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

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  2. Reviews
  3. Swarna Prashana – faith in the embrace of research
  4. A review on the concept of aging in Ayurveda literature
  5. Ethno-pharmacology of Asaroon (Asarum europaeum L.) with special reference to Unani System of Medicine
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  15. Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
  16. Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis
  17. The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism
  18. Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses
  19. Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
  20. Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats
  21. The effect of Cinnamomum cassia extract on oxidative stress in the liver and kidney of STZ-induced diabetic rats
  22. Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats
  23. Ameliorating activity of polyphenolic-rich extracts of Basella rubra L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats
  24. Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice
  25. The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance
  26. Anti-obesity effects of the n-butanol fraction of the methanolic leaf extract of Artemisia campestris from Tunisian pharmacopeia in male Wistar rats
  27. Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats
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  32. Immediate effects of the practise of Sheethali pranayama on heart rate and blood pressure parameters in healthy volunteers
  33. Effects of 12 sessions of steam bath intervention on spirometry parameters among healthy adult volunteers
  34. The effects of psychological counseling and acupressure based on couple therapy procedure for alleviation of vomiting and nausea in pregnant women in Iran country
  35. “The immediate effect of neutral spinal compress on heart rate variability in hypertensive individuals”
  36. Effect of whole-body vibration after a resistance exercise bout on heart rate variability in hypertensive population
  37. Wet-cupping on calf muscles in polycystic ovary syndrome: a quasi-experimental study
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  39. Evaluation of general body temperament and uterine dystemperament in amenorrhoea: a cross-sectional analytical study
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https://doi.org/10.1515/jcim-2021-0090
Schlagwörter für diesen Artikel
ayurved; ethnopharmacology; insulin resistance; phytomedicine; type 2 diabetes mellitus

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Swarna Prashana – faith in the embrace of research
  4. A review on the concept of aging in Ayurveda literature
  5. Ethno-pharmacology of Asaroon (Asarum europaeum L.) with special reference to Unani System of Medicine
  6. Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review
  7. The anti-cancer properties of neem (Azadirachta indica) through its antioxidant activity in the liver: its pharmaceutics and toxic dosage forms. A literature review
  8. The role of acupuncture for myofascial pain syndrome (MPS) in interventional pain management
  9. Research Articles
  10. Identification of phenolic compounds in the buds of Algerian Pistacia atlantica desf. Subsp. atlantica by antioxidant activity guided fractionation
  11. Optimization of water-based ultrasonic-microwave assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
  12. Proximate analysis, HPTLC finger print analysis and multi spectrometric analysis of Strychnos nux-vomica nuts
  13. Amelioration of sodium fluoride induced oxidative stress by Cynometra travancorica Bedd in mice
  14. The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements
  15. Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
  16. Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis
  17. The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism
  18. Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses
  19. Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
  20. Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats
  21. The effect of Cinnamomum cassia extract on oxidative stress in the liver and kidney of STZ-induced diabetic rats
  22. Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats
  23. Ameliorating activity of polyphenolic-rich extracts of Basella rubra L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats
  24. Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice
  25. The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance
  26. Anti-obesity effects of the n-butanol fraction of the methanolic leaf extract of Artemisia campestris from Tunisian pharmacopeia in male Wistar rats
  27. Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats
  28. Preventing SARS-CoV-2 transmission in the emergency department by implementing a separate pathway for patients with respiratory conditions
  29. Clinical significance of serum gonadotropin and androgen levels among Egyptian overweight/obese pubertal girls
  30. Preference between serum homocysteine and urinary periostin as early predictive biomarkers of renal dysfunction among uncontrolled diabetics
  31. Mizaj assessment in multiple sclerosis patients based on Persian Medicine
  32. Immediate effects of the practise of Sheethali pranayama on heart rate and blood pressure parameters in healthy volunteers
  33. Effects of 12 sessions of steam bath intervention on spirometry parameters among healthy adult volunteers
  34. The effects of psychological counseling and acupressure based on couple therapy procedure for alleviation of vomiting and nausea in pregnant women in Iran country
  35. “The immediate effect of neutral spinal compress on heart rate variability in hypertensive individuals”
  36. Effect of whole-body vibration after a resistance exercise bout on heart rate variability in hypertensive population
  37. Wet-cupping on calf muscles in polycystic ovary syndrome: a quasi-experimental study
  38. Auricular field nerve stimulation using the NSS-2 BRIDGE® device as an alternative to opioids following kidney donor surgery
  39. Evaluation of general body temperament and uterine dystemperament in amenorrhoea: a cross-sectional analytical study
  40. Short Communication
  41. Isolation, characterization, and antimicrobial activity of communic acid from Juniperus phoenicea
  42. Letter to the Editor
  43. Can silymarin ameliorate β-thalassemia major-induced osteopenia/osteoporosis?
  44. Case Reports
  45. Management of psoriasis with Ayurveda Panchakarma and Manibhadragula as Shodhana Rasayana – a case report
  46. Psychogenic pseudo-myasthenic ptosis – management with ayurvedic medicines and Smriti meditation
  47. Education Forum
  48. Tongue stretching: technique and clinical proposal
  49. Simulation-based ventilatory training for the caregivers at primary and rural health care workers in Central India for dealing with COVID-19 pandemic: recommendations
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